Assay ID | Title | Year | Journal | Article |
AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
| Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
AID718800 | Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells at 500 nM by scintillation counting | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors. |
AID698098 | Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation at 10 uM after 2 hrs by liquid scintillation counting relative to NPVF | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
| Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. |
AID1167972 | Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. |
AID1820162 | Selectivity ratio of Ki for displacement of [125I]-1DMeNPFF from human NPFF2 receptor expressed in CHO cells to Ki for displacement of [125I]-1DMeNPFF from human NPFF1 receptor expressed in CHO cells | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
| Identification of an |
AID697924 | Agonist activity at human NPFF2 receptor F/Y7.35A mutant assessed as [3H]inositol phosphate accumulation at 10 uM after 2 hrs by liquid scintillation counting relative to NPFF | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
| Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. |
AID1820161 | Displacement of [125I]-1DMeNPFF from recombinant human NPFF2 receptor expressed in CHO cells by TopCount scintillation counting method | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
| Identification of an |
AID570382 | Displacement of [125I]kisspeptin-15 from GPR54 | 2011 | ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
| Activation of Neuropeptide FF Receptors by Kisspeptin Receptor Ligands. |
AID706415 | Activation of NPFF2R in Sprague-Dawley rat cardiac myocytes assessed as effect on cardiac function at 10 nM incubated for 20 mins | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| Structure-activity studies of RFamide-related peptide-1 identify a functional receptor antagonist and novel cardiac myocyte signaling pathway involved in contractile performance. |
AID1536314 | Antagonist activity at NPFF1 receptor (unknown origin) expressed in HEK293A cells assessed as reversal of NPPF induced inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins | | | |
AID1536327 | Antinociceptive activity in Kunming mouse model of thermal-induced nociception assessed as increase in latency to tail withdrawal at 10 nmol, icv measured up to 60 mins by tail flick test | | | |
AID1820186 | Effect on Luteinizing hormone release in Syrian hamster mouse assessed as increase in LD level at 10 nmol, icv after 30 mins by radioimmunoassay | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
| Identification of an |
AID1536315 | Antagonist activity at NPFF2 receptor (unknown origin) expressed in HEK293A cells assessed as reversal of NPPF induced inhibition of forskolin-stimulated cAMP accumulation measured after 30 mins | | | |
AID697926 | Agonist activity at human NPFF2 receptor F/Y7.35A mutant assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
| Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. |
AID1167970 | Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. |
AID698101 | Agonist activity at human NPFF1 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
| Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. |
AID697949 | Agonist activity at human NPFF1 receptor F/Y7.35A mutant assessed as [3H]inositol phosphate accumulation at 10 uM after 2 hrs by liquid scintillation counting relative to NPVF | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
| Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. |
AID706416 | Antagonist activity at NPFF2R in Sprague-Dawley rat cardiac myocytes assessed as attenuation of human RFRP-1-induced reduction in cardiac function at 10 nM incubated for 20 mins | 2012 | Journal of medicinal chemistry, Sep-13, Volume: 55, Issue:17
| Structure-activity studies of RFamide-related peptide-1 identify a functional receptor antagonist and novel cardiac myocyte signaling pathway involved in contractile performance. |
AID697951 | Agonist activity at human NPFF1 receptor F/Y7.35A mutant assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
| Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. |
AID697950 | Ratio of EC50 for human NPFF1 receptor F/Y7.35A mutant to EC50 for human wild type NPFF1 receptor | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
| Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. |
AID718798 | Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells at 5 uM by scintillation counting | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors. |
AID718801 | Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells at 5 uM by scintillation counting | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors. |
AID698096 | Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation at 10 uM after 2 hrs by liquid scintillation counting relative to NPFF | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
| Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. |
AID1740832 | Displacement of [125I]YVP from human NPFFR1 expressed in CHO cells | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21
| Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development. |
AID1536319 | Effect on neurite outgrowth in mouse Neuro2a cells at 10 uM after 18 hrs by phase contrast microscopic analysis relative to control | | | |
AID698097 | Agonist activity at human NPFF2 receptor expressed in COS1 cells assessed as [3H]inositol phosphate accumulation after 2 hrs by liquid scintillation counting | 2012 | Journal of medicinal chemistry, Jul-12, Volume: 55, Issue:13
| Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. |
AID1740836 | Antagonist activity at human NPFFR2 expressed in green monkey COS1 assessed as antagonist Ke at 7.5 uM incubated for 30 mins by [35S]GTPgammaS binding based scintillation counting method | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21
| Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development. |
AID1820185 | Analgesic activity in NPFF induced C57BL/6N mouse model of analgesia assessed as reversal of NPFF effect on morphine analgesia at 10 nmol, icv | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
| Identification of an |
AID1167971 | Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay | 2014 | Bioorganic & medicinal chemistry, Nov-01, Volume: 22, Issue:21
| Peptidomimetics of Arg-Phe-NH2 as small molecule agonists of Mas-related gene C (MrgC) receptors. |
AID1820160 | Displacement of [125I]-1DMeNPFF from recombinant human NPFF1 receptor expressed in CHO cells by TopCount scintillation counting method | 2021 | Journal of medicinal chemistry, 06-10, Volume: 64, Issue:11
| Identification of an |
AID718796 | Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells by scintillation counting | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors. |
AID1740833 | Displacement of [125I]Tyr-NPFF from human NPFFR2 expressed in green monkey Cos-1 cells | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21
| Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development. |
AID1740837 | Antagonist activity at human NPFFR1 expressed in CHO cells assessed as reversal of NPVF-induced inhibition of forskolin-stimulated cAMP accumulation incubated for 10 mins by liquid scintillation counting method | 2020 | Journal of medicinal chemistry, 11-12, Volume: 63, Issue:21
| Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development. |
AID570392 | Agonist activity at GPR54 expressed in CHO cells assessed as increase of intracellular calcium mobilization at 10 uM after 1 hr | 2011 | ACS medicinal chemistry letters, Jan-13, Volume: 2, Issue:1
| Activation of Neuropeptide FF Receptors by Kisspeptin Receptor Ligands. |
AID718797 | Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF2 receptor expressed in CHO cells at 500 nM by scintillation counting | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors. |
AID1536318 | Antagonist activity at NPFF2 receptor in mouse Neuro2a cells assessed as inhibition of NPFF-induced neurite outgrowth by measuring neurite outgrowth at 10 uM after 18 hrs by phase contrast microscopic analysis (Rvb = 24.05 +/- 1.19%) | | | |
AID718799 | Displacement of [3H]FFRF-NH2 from human flag-tagged NPFF1 receptor expressed in CHO cells by scintillation counting | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors. |
AID1346349 | Human NPFF2 receptor (Neuropeptide FF/neuropeptide AF receptors) | 2006 | Proceedings of the National Academy of Sciences of the United States of America, Jan-10, Volume: 103, Issue:2
| RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. |
AID1346421 | Human NPFF1 receptor (Neuropeptide FF/neuropeptide AF receptors) | 2006 | Proceedings of the National Academy of Sciences of the United States of America, Jan-10, Volume: 103, Issue:2
| RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |