Compounds > phorbol 12,13-dibutyrate
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phorbol 12,13-dibutyrate and Pain

phorbol 12,13-dibutyrate has been researched along with Pain in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (45.45)18.2507
2000's6 (54.55)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fujita, T; Kumamoto, E; Yang, K1
Ahern, GP; Brooks, IM; Miyares, RL; Wang, XB1
Carlton, SM; Castañeda-Hernandez, G; Jimenez-Andrade, JM; Valencia de Ita, S; Yamani, A; Zhou, S1
Premkumar, LS; Sikand, P1
Furuya, M; Kawano, K; Kobayashi, Y; Maitani, Y; Narita, M; Niikura, K; Okutsu, D; Suzuki, T1
Coderre, TJ; Parent, A; Pitcher, GM; Quirion, R; Yashpal, K1
Black, IB; Elkabes, S; Selcher, JC; Shors, TJ1
Koda, H; Kumazawa, T; Mizumura, K1
Kamei, J; Ohsawa, M1
Chabot, JG; Coderre, TJ; Dray, A; Fundytus, ME; Henry, JL; Lefebvre, CD; Osborne, MG; Yashpal, K1
Hayes, RL; Mao, J; Mayer, DJ; Price, DD1

Other Studies

11 other study(ies) available for phorbol 12,13-dibutyrate and Pain

ArticleYear
Adenosine inhibits GABAergic and glycinergic transmission in adult rat substantia gelatinosa neurons.
    Journal of neurophysiology, 2004, Volume: 92, Issue:5

    Topics: 4-Aminopyridine; 8-Bromo Cyclic Adenosine Monophosphate; Adenosine; Animals; Colforsin; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Neurons; Pain; Phorbol 12,13-Dibutyrate; Potassium Channel Blockers; Potassium Channels; Rats; Substantia Gelatinosa; Synaptic Transmission

2004
Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, May-25, Volume: 25, Issue:21

    Topics: Adenosine Triphosphate; Aminobutyrates; Animals; Arachidonic Acids; Behavior, Animal; Bradykinin; Calcium; Calcium Channel Blockers; Capsaicin; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Interactions; Electric Stimulation; Endocannabinoids; Extracellular Space; Humans; Hydrogen-Ion Concentration; Magnesium Sulfate; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Microinjections; Models, Biological; Mutagenesis; Neurons; Nodose Ganglion; Oocytes; Pain; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Polyunsaturated Alkamides; Protein Kinase C; Signal Transduction; Temperature; Time Factors; Transfection; TRPV Cation Channels

2005
Mechanism by which peripheral galanin increases acute inflammatory pain.
    Brain research, 2005, Sep-21, Volume: 1056, Issue:2

    Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Functional Laterality; Galanin; Inflammation; Male; Naphthalenes; Pain; Pain Measurement; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Wistar; Time Factors

2005
Potentiation of glutamatergic synaptic transmission by protein kinase C-mediated sensitization of TRPV1 at the first sensory synapse.
    The Journal of physiology, 2007, Jun-01, Volume: 581, Issue:Pt 2

    Topics: Animals; Bradykinin; Calcium; Capsaicin; Cells, Cultured; Coculture Techniques; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Ganglia, Spinal; Glutamine; Indoles; Maleimides; Neuronal Plasticity; Neurons, Afferent; Pain; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Phosphorylation; Posterior Horn Cells; Presynaptic Terminals; Protein Kinase C; Rats; Rats, Sprague-Dawley; Synaptic Transmission; TRPV Cation Channels; Type C Phospholipases

2007
Implication of spinal protein kinase Cgamma isoform in activation of the mouse brain by intrathecal injection of the protein kinase C activator phorbol 12,13-dibutyrate using functional magnetic resonance imaging analysis.
    Neuroscience letters, 2008, Mar-05, Volume: 433, Issue:1

    Topics: Afferent Pathways; Animals; Brain; Brain Mapping; Emotions; Enzyme Activation; Enzyme Activators; Hyperalgesia; Injections, Spinal; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Pain Threshold; Phorbol 12,13-Dibutyrate; Protein Kinase C; Spinal Cord; Time Factors

2008
Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:5 Pt 1

    Topics: Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Formaldehyde; Functional Laterality; Hindlimb; Hot Temperature; Hyperalgesia; Indoles; Injections, Spinal; Kinetics; Male; Maleimides; Pain; Phenanthridines; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Spinal Cord; Time Factors

1995
Stress persistently increases NMDA receptor-mediated binding of [3H]PDBu (a marker for protein kinase C) in the amygdala, and re-exposure to the stressful context reactivates the increase.
    Brain research, 1997, Mar-07, Volume: 750, Issue:1-2

    Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Autoradiography; Biomarkers; Brain; Brain Mapping; Cerebral Cortex; Electroshock; Enzyme Activation; Excitatory Amino Acid Antagonists; Hippocampus; Male; Organ Specificity; Pain; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Restraint, Physical; Stress, Psychological; Tritium

1997
Evidence that protein kinase C activation is involved in the excitatory and facilitatory effects of bradykinin on canine visceral nociceptors in vitro.
    Neuroscience letters, 1997, Nov-14, Volume: 237, Issue:1

    Topics: Adaptation, Physiological; Animals; Bradykinin; Dogs; Male; Neural Conduction; Nociceptors; Pain; Phorbol 12,13-Dibutyrate; Protein Kinase C; Sensory Receptor Cells; Sensory Thresholds; Staurosporine; Temperature; Testis; Visceral Afferents

1997
Possible involvement of spinal protein kinase C in thermal allodynia and hyperalgesia in diabetic mice.
    European journal of pharmacology, 1999, May-21, Volume: 372, Issue:3

    Topics: Analysis of Variance; Animals; Capsaicin; Carbazoles; Carcinogens; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Indoles; Male; Mice; Mice, Inbred ICR; Naphthalenes; Pain; Pain Measurement; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Spinal Cord

1999
Knockdown of spinal metabotropic glutamate receptor 1 (mGluR(1)) alleviates pain and restores opioid efficacy after nerve injury in rats.
    British journal of pharmacology, 2001, Volume: 132, Issue:1

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Blotting, Western; Cold Temperature; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Knockout; Morphine; N-Methylaspartate; Oligonucleotides, Antisense; Pain; Pain Measurement; Phorbol 12,13-Dibutyrate; Rats; Rats, Long-Evans; Receptors, Metabotropic Glutamate; Sciatic Nerve; Touch

2001
Pain-related increases in spinal cord membrane-bound protein kinase C following peripheral nerve injury.
    Brain research, 1992, Aug-14, Volume: 588, Issue:1

    Topics: Animals; Behavior, Animal; G(M1) Ganglioside; Pain; Peripheral Nerve Injuries; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Spinal Cord

1992