Matrix metalloproteinase-26

A matrix metalloproteinase-26 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NRE1]

MMP-26;
EC 3.4.24.-;
Endometase;
Matrilysin-2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
marimastat	Homo sapiens (human)	IC50	10.0000	1	1
ilomastat	Homo sapiens (human)	IC50	0.0170	2	2

This protein enables 2 target(s):

Target	Category	Definition
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
metalloendopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]

This protein is located in 1 target(s):

Target	Category	Definition
extracellular matrix	cellular component	A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

This protein is involved in 4 target(s):

Target	Category	Definition
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
negative regulation of inflammatory response	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai]
collagen catabolic process	biological process	The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. [GOC:mah, ISBN:0815316194]
extracellular matrix organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. [GOC:mah]