pyridoxal phosphate has been researched along with Pain in 11 studies
Pyridoxal Phosphate: This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
pyridoxal 5'-phosphate : The monophosphate ester obtained by condensation of phosphoric acid with the primary hydroxy group of pyridoxal.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Furthermore, using an ex-vivo assay system, we found that compound 36j potently inhibited pain signaling in the rat dorsal horn with 20 μM 36j displaying 65% inhibition while 20 μM pregabalin, a clinically available drug, showed only 31% inhibition." | 3.79 | Design and synthesis of potent and selective P2X₃ receptor antagonists derived from PPADS as potential pain modulators. ( Cho, JH; Jung, KY; Jung, Y; Kim, MH; Kim, YC; Ko, H; Park, CS, 2013) |
| " Adverse events were reported for 23% of the patients; most were mild to moderate in intensity, did not require treatment, and were not drug related." | 2.69 | Safety and efficacy of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: results of the U.S. multicenter phase III clinical trials (safety). ( Anderson, MW; Borello, JA; Bova, JG; Brown, JJ; Chezmar, JL; Dachman, AH; Federle, MP; Fenstermacher, M; Foster, GS; Francis, IR; Freeny, PC; Halford, HH; Harmon, B; Harms, SE; Johnson, CD; Kenney, PJ; Klippenstein, DL; Lee, JK; Mattrey, R; Mitchell, DG; Pelsang, RE; Rubin, DL; Saini, S; Semelka, RC; Turner, DA; Weinreb, JC, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 7 (63.64) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cho, JH | 1 |
| Jung, KY | 1 |
| Jung, Y | 1 |
| Kim, MH | 1 |
| Ko, H | 1 |
| Park, CS | 1 |
| Kim, YC | 1 |
| Trippe, BS | 1 |
| Barrentine, LW | 1 |
| Curole, MV | 1 |
| Tipa, E | 1 |
| McCleskey, EW | 1 |
| Tsuda, M | 2 |
| Shigemoto-Mogami, Y | 1 |
| Koizumi, S | 1 |
| Mizokoshi, A | 1 |
| Kohsaka, S | 1 |
| Salter, MW | 1 |
| Inoue, K | 2 |
| Martucci, C | 1 |
| Trovato, AE | 1 |
| Costa, B | 1 |
| Borsani, E | 1 |
| Franchi, S | 1 |
| Magnaghi, V | 1 |
| Panerai, AE | 1 |
| Rodella, LF | 1 |
| Valsecchi, AE | 1 |
| Sacerdote, P | 1 |
| Colleoni, M | 1 |
| Ueno, S | 1 |
| Masaki, E | 1 |
| Ebisawa, T | 1 |
| Kondo, I | 1 |
| Hayashida, K | 1 |
| Matsumoto, Y | 1 |
| Kawamura, M | 1 |
| Federle, MP | 1 |
| Chezmar, JL | 1 |
| Rubin, DL | 1 |
| Weinreb, JC | 1 |
| Freeny, PC | 1 |
| Semelka, RC | 1 |
| Brown, JJ | 1 |
| Borello, JA | 1 |
| Lee, JK | 1 |
| Mattrey, R | 1 |
| Dachman, AH | 1 |
| Saini, S | 1 |
| Harmon, B | 1 |
| Fenstermacher, M | 1 |
| Pelsang, RE | 1 |
| Harms, SE | 1 |
| Mitchell, DG | 1 |
| Halford, HH | 1 |
| Anderson, MW | 1 |
| Johnson, CD | 1 |
| Francis, IR | 1 |
| Bova, JG | 1 |
| Kenney, PJ | 1 |
| Klippenstein, DL | 1 |
| Foster, GS | 1 |
| Turner, DA | 1 |
| Fukuhara, N | 1 |
| Imai, Y | 1 |
| Sakakibara, A | 1 |
| Morita, K | 1 |
| Kitayama, S | 1 |
| Tanne, K | 1 |
| Dohi, T | 1 |
| Honore, P | 1 |
| Mikusa, J | 1 |
| Bianchi, B | 1 |
| McDonald, H | 1 |
| Cartmell, J | 1 |
| Faltynek, C | 1 |
| Jarvis, MF | 1 |
| Dumas, M | 1 |
| Girard, PL | 1 |
| Konaté, S | 1 |
1 trial available for pyridoxal phosphate and Pain
| Article | Year |
|---|---|
Safety and efficacy of mangafodipir trisodium (MnDPDP) injection for hepatic MRI in adults: results of the U.S. multicenter phase III clinical trials (safety).
Topics: Abdominal Pain; Adult; Aged; Aged, 80 and over; Cardiovascular Diseases; Contrast Media; Diagnosis, | 2000 |
10 other studies available for pyridoxal phosphate and Pain
| Article | Year |
|---|---|
Design and synthesis of potent and selective P2X₃ receptor antagonists derived from PPADS as potential pain modulators.
Topics: Animals; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Structure; Oocytes; Pain; | 2013 |
Nutritional management of patients with diabetic peripheral neuropathy with L-methylfolate-methylcobalamin-pyridoxal-5-phosphate: results of a real-world patient experience trial.
Topics: Adult; Aged; Diabetic Neuropathies; Female; Humans; Male; Middle Aged; Pain; Pyridoxal Phosphate; Qu | 2016 |
Neurobiology: new player in pain.
Topics: Animals; Chronic Disease; Microglia; Pain; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; | 2003 |
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury.
Topics: Adenosine Triphosphate; Animals; Astrocytes; Cells, Cultured; Disease Models, Animal; Male; Microgli | 2003 |
The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1 beta, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice.
Topics: Animals; Behavior, Animal; Central Nervous System; Drug Delivery Systems; Interleukin-1beta; Interle | 2008 |
Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Male; Mice; Motor Activi | 1999 |
P2-purinergic receptor antagonists reduce the minimum alveolar concentration of inhaled volatile anesthetics.
Topics: Adenosine Triphosphate; Anesthesia; Anesthetics, Inhalation; Animals; Antineoplastic Agents; Brain; | 2000 |
Regulation of the development of allodynia by intrathecally administered P2 purinoceptor agonists and antagonists in mice.
Topics: Adenosine Triphosphate; Animals; Dinoprostone; Dizocilpine Maleate; Injections, Spinal; Male; Mice; | 2000 |
TNP-ATP, a potent P2X3 receptor antagonist, blocks acetic acid-induced abdominal constriction in mice: comparison with reference analgesics.
Topics: Abdomen; Acetic Acid; Adenosine Triphosphate; Analgesics; Animals; Antineoplastic Agents; Behavior, | 2002 |
[Analgesic effect of a polyvitamin B complex in African pathology].
Topics: Adult; Africa; Analgesics; Drug Combinations; Humans; Nervous System Diseases; Pain; Paraplegia; Pyr | 1975 |