A lactase/phlorizin hydrolase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09848]
Lactase-glycosylceramidase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 1-deoxynojirimycin | Homo sapiens (human) | IC50 | 62.0000 | 1 | 1 |
| miglustat | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| migalastat | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| miglitol | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| n-(5-adamantane-1-yl-methoxy-pentyl)deoxynojirimycin | Homo sapiens (human) | IC50 | 35.0000 | 2 | 2 |
| l-altro-1-deoxynojirimycin | Homo sapiens (human) | IC50 | 400.0000 | 1 | 1 |
This protein enables 8 target(s):
| Target | Category | Definition |
|---|---|---|
| lactase activity | molecular function | Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose. [PMID:12023280] |
| galactosylceramidase activity | molecular function | Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine. [EC:3.2.1.46] |
| glucosylceramidase activity | molecular function | Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine. [EC:3.2.1.45] |
| beta-glucosidase activity | molecular function | Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose. [EC:3.2.1.21, PMID:12594539] |
| glycosylceramidase activity | molecular function | Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine. [PMID:10692580, PMID:9762914] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| cellobiose glucosidase activity | molecular function | Catalysis of the reaction: D-cellobiose + H2O = 2 D-glucose. [PMID:15604686, RHEA:30679] |
| phlorizin hydrolase activity | molecular function | Catalysis of the reaction: phlorizin + H2O = beta-D-glucose + phloretin. [PMID:9762914, RHEA:69639] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| external side of apical plasma membrane | cellular component | The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface. [GOC:ab, GOC:dos] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| lactose catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose. [GOC:go_curators] |
| glycosylceramide catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group. [GOC:ai] |
| quercetin catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of quercetin. [GOC:TermGenie, GOC:yaf, UniPathway:UPA00724] |
| cellobiose catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of a cellobiose. [GOC:mengo_curators] |