7-n-(4-hydroxyphenyl)mitomycin c profile

ID Source	ID
PubMed CID	14136266
MeSH ID	M0088831

Synonym
azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-6-((4-hydroxyphenyl)amino)-8a-methoxy-5-methyl-, (1as-(1aalpha,8beta,8aalpha,8balpha))-
7-n-(4-hydroxyphenyl)mitomycin c
azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-6-(p-hydroxyanilino)-8a-methoxy-5-methyl-, 8-carbamate (ester)
n(6)-4-hydroxyphenylmitomycin c
70343-57-6
[(4s,6s,7r,8s)-11-(4-hydroxyanilino)-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
PD161200
AKOS040750001

Excerpt	Reference	Relevance
" The serum level of M-83 detected by bioassay was biphasic, elimination half-life T1/2 beta was 10."	( Antitumor activity and pharmacokinetics of 7-N-(p-hydroxyphenyl)mitomycin C in human tumor xenografts transplanted into nude mice. Asanuma, F, 1985)	0.27
" These pharmacokinetic behaviours of KW-2083 might be related to the lower toxicity and higher therapeutic ratio in experimental animals."	( [Pharmacokinetics of mitomycin C and its derivative (KW-2083)]. Fujita, H, 1982)	0.26

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	28 (96.55)	18.7374
1990's	1 (3.45)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	29 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
adenine [no description available]	1.96	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	4.67	29	mitomycin	alkylating agent; antineoplastic agent
dithiothreitol 1,4-dimercaptobutane-2,3-diol : A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group.. 1,4-dithiothreitol : The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.	1.96	1	1,4-dimercaptobutane-2,3-diol; butanediols; dithiol; glycol; thiol	chelator; human metabolite; reducing agent
sodium borohydride sodium borohydride: RN given refers to parent cpd	1.96	1	inorganic sodium salt; metal tetrahydridoborate
n(6)-((dimethylamino)methylene)mitomycin c N(6)-((dimethylamino)methylene)mitomycin C: mitomycin C analog; structure given in first source	1.97	1
methylnitronitrosoguanidine Methylnitronitrosoguanidine: A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.. N-methyl-N'-nitro-N-nitrosoguanidine : An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position	2.37	2	nitroso compound	alkylating agent
enng [no description available]	2.37	2

Condition	Relationship Strength	Studies
Experimental Neoplasms [description not available]	2.65	3
Carcinoma, Bronchial [description not available]	1.96	1
Cancer of Lung [description not available]	3.57	9
Carcinoma, Bronchogenic Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.	1.96	1
Lung Neoplasms Tumors or cancer of the LUNG.	3.57	9
Breast Cancer [description not available]	2.37	2
Cancer of Colon [description not available]	3.06	5
Benign Neoplasms [description not available]	2.88	4
Cancer of Stomach [description not available]	3.21	6
Emesis [description not available]	2.36	2
Breast Neoplasms Tumors or cancer of the human BREAST.	2.37	2
Colonic Neoplasms Tumors or cancer of the COLON.	3.06	5
Nausea An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.	2.88	4
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.88	4
Stomach Neoplasms Tumors or cancer of the STOMACH.	3.21	6
Vomiting The forcible expulsion of the contents of the STOMACH through the MOUTH.	2.36	2
Cancer of Esophagus [description not available]	1.96	1
Cancer of Liver [description not available]	1.96	1
Anorexia The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA.	2.65	3
Esophageal Neoplasms Tumors or cancer of the ESOPHAGUS.	1.96	1
Liver Neoplasms Tumors or cancer of the LIVER.	1.96	1
Cancer of Pancreas [description not available]	1.96	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	1.96	1
Adenocarcinoma, Basal Cell [description not available]	3.06	5
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	3.06	5
Pyrexia [description not available]	1.96	1
Cancer of Ovary [description not available]	2.37	2
Ache [description not available]	1.96	1
Pleurisy INFLAMMATION of PLEURA, the lining of the LUNG. When PARIETAL PLEURA is involved, there is pleuritic CHEST PAIN.	1.96	1
Fever An abnormal elevation of body temperature, usually as a result of a pathologic process.	1.96	1
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	2.37	2
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	1.96	1
Delayed Hypersensitivity [description not available]	1.96	1
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	3.06	5
Carcinoma, Anaplastic [description not available]	2.36	2
Sarcoma 180 An experimental sarcoma of mice.	1.96	1
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	2.36	2
Fibrosarcoma A sarcoma derived from deep fibrous tissue, characterized by bundles of immature proliferating fibroblasts with variable collagen formation, which tends to invade locally and metastasize by the bloodstream. (Stedman, 25th ed)	1.96	1
Experimental Hepatoma [description not available]	1.96	1
Carcinoma, Epidermoid [description not available]	2.37	2
Dysembryoma [description not available]	1.96	1
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	2.37	2
Teratoma A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)	1.96	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.96	1
Experimental Leukemia [description not available]	1.95	1
Carcinoma, Oat Cell [description not available]	1.96	1
Carcinoma, Small Cell An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)	1.96	1
Thrombopenia [description not available]	1.96	1
Thrombocytopenia A subnormal level of BLOOD PLATELETS.	1.96	1
Cancer of Prostate [description not available]	1.96	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	1.96	1
Biliary Tract Cancer [description not available]	1.96	1
Biliary Tract Neoplasms Tumors or cancer in the BILIARY TRACT including the BILE DUCTS and the GALLBLADDER.	1.96	1

7-n-(4-hydroxyphenyl)mitomycin c

Cross-References

Synonyms (8)

Research Excerpts

Pharmacokinetics

Research

Studies (29)

Study Types

7-n-(4-hydroxyphenyl)mitomycin c

Cross-References

Synonyms (8)

Research Excerpts

Pharmacokinetics

Research

Studies (29)

Study Types

Related Drugs (7)

Related Conditions (53)