Page last updated: 2024-12-07
r 84760
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
R 84760: kappa opioid receptor agonist; R-84760 is the (1R,2S)-isomer; R-86428 is the (1S,2R)-isomer; R-84761 is the (1R,2R)-isomer; R-86436 is the (1S,2S)-isomer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 133035 |
| MeSH ID | M0240662 |
Synonyms (22)
| Synonym |
|---|
| gw7gy73veg , |
| unii-gw7gy73veg |
| 157824-23-2 |
| r 84760 |
| r 86436 |
| r 84761 |
| r-84760 |
| 3-(1-pyrrolidinylmethyl)-4-(5,6-dichloro-1-indancarbonyl)-tetrahydro-1,4-thiazine hydrochloride |
| r 86428 |
| r-86428 |
| thiomorpholine, 4-((5,6-dichloro-2,3-dihydro-1h-inden-1-yl)carbonyl)-3-(1-pyrrolidinylmethyl)-, monohydrochloride, (r-(r*,s*))- |
| r-84761 |
| r-86436 |
| 157824-23-2 (hcl) |
| ((s)-5,6-dichloro-2,3-dihydro-1h-inden-1-yl)((r)-3-(pyrrolidin-1-ylmethyl)thiomorpholino)methanone hydrochloride |
| r-84760 hydrochloride |
| DTXSID60935809 |
| (5,6-dichloro-2,3-dihydro-1h-inden-1-yl){3-[(pyrrolidin-1-yl)methyl]thiomorpholin-4-yl}methanone--hydrogen chloride (1/1) |
| [(1s)-5,6-dichloro-2,3-dihydro-1h-inden-1-yl]-[(3r)-3-(pyrrolidin-1-ylmethyl)thiomorpholin-4-yl]methanone;hydrochloride |
| r84760 |
| methanone, ((1s)-5,6-dichloro-2,3-dihydro-1h-inden-1-yl)((3r)-3-(1-pyrrolidinylmethyl)-4-thiomorpholinyl)-, hydrochloride (1:1) |
| AKOS040749268 |
Research Excerpts
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " The plasma concentration of unchanged form after administration at a trace dosage amount was able to be monitored." | ( Quantitative analysis of R-84760, a selective kappa-opioid receptor agonist, in plasma by liquid chromatography with electrospray ionization tandem mass spectrometry. Kobayashi, N; Naganuma, H, 1999) | 0.3 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (6)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (66.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.10
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.10) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||