(Ethylenedinitrilo)-tetramethylenephosphonic acid, also known as **EDTMP**, is a complex organic compound with the chemical formula C6H16N2O12P4.
Here's a breakdown of its structure and importance:
**Structure:**
* **Ethylenedinitrilo:** This part refers to the presence of a central ethylene diamine group (NH2CH2CH2NH2).
* **Tetramethylenephosphonic acid:** This indicates four phosphonic acid groups (PO3H2) attached to the central ethylenediamine group.
**Importance in Research:**
EDTMP plays a crucial role in various research areas, primarily due to its:
* **Chelating Properties:** EDTMP is a powerful chelating agent, meaning it can bind to and sequester metal ions like calcium, magnesium, iron, and copper. This property makes it useful in:
* **Water Treatment:** EDTMP is widely used in boiler water treatment to prevent scale formation and corrosion. It binds to metal ions, preventing their deposition on boiler surfaces.
* **Metal Processing:** EDTMP is used in metal plating, etching, and other metal processing applications to control metal ion concentrations.
* **Biomedical Research:** EDTMP can be used to study the role of metal ions in biological systems.
* **Biocompatibility:** EDTMP is relatively non-toxic and biocompatible, making it suitable for applications like:
* **Drug Delivery:** EDTMP can be used to encapsulate and deliver drugs to specific tissues or organs.
* **Bioimaging:** EDTMP-based chelates can be used as contrast agents in magnetic resonance imaging (MRI).
* **Environmental Applications:** EDTMP has potential applications in:
* **Wastewater Treatment:** EDTMP can be used to remove heavy metals from wastewater.
* **Soil Remediation:** EDTMP can help in extracting heavy metals from contaminated soil.
**Research Areas:**
EDTMP is a subject of ongoing research in various fields, including:
* **Materials Science:** Development of new EDTMP-based materials for applications in catalysis, sensors, and energy storage.
* **Biochemistry:** Understanding the interaction of EDTMP with biomolecules and its potential applications in drug delivery and bioimaging.
* **Environmental Chemistry:** Investigation of EDTMP's effectiveness in remediation of heavy metal pollution.
**Overall, EDTMP is a versatile compound with numerous applications in research and industry due to its chelating properties, biocompatibility, and potential for use in diverse fields.**
(ethylenedinitrilo)-tetramethylenephosphonic acid: structure; RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 15025 |
| CHEMBL ID | 1208647 |
| SCHEMBL ID | 22492 |
| MeSH ID | M0070974 |
| Synonym |
|---|
| ethylenebis(nitrilodimethylene)tetraphosphonic acid |
| v4cp8rsx7v , |
| unii-v4cp8rsx7v |
| phosphonic acid, p,p',p'',p'''-(1,2-ethanediylbis(nitrilobis(methylene)))tetrakis- |
| ethylenediamine tetrakis(methylene phosphonic acid) |
| BB 0218127 |
| STK368766 |
| [ethane-1,2-diylbis(nitrilodimethanediyl)]tetrakis(phosphonic acid) |
| (ethane-1,2-diylbis(nitrilobis(methylene)))tetrakisphosphonic acid |
| (ethylenedinitrilo)-tetramethylenephosphonic acid |
| einecs 215-851-5 |
| phosphonic acid, (1,2-ethanediylbis(nitrilobis(methylene)))tetrakis- |
| AKOS000365812 |
| [2-[bis(phosphonomethyl)amino]ethyl-(phosphonomethyl)amino]methylphosphonic acid |
| ethylenediaminetetra(methylenephosphonic acid) |
| n,n,n',n'-ethylenediaminetetrakis(methylenephosphonic acid) |
| 1429-50-1 |
| E0393 |
| BBL000007 |
| 61827-49-4 |
| 22036-77-7 |
| einecs 244-742-5 |
| tetrasodium tetrahydrogen (ethane-1,2-diylbis(nitrilobis(methylene)))tetrakisphosphonate |
| ec 244-742-5 |
| einecs 263-254-3 |
| edtmp |
| masquol p 430na |
| phosphonic acid, (1,2-ethanediylbis(nitrilobis(methylene)))tetrakis-, hexasodium salt |
| hexasodium dihydrogen (ethane-1,2-diylbis(nitrilobis(methylene)))tetrakisphosphonate |
| ethylenediamine tetrakis(methylene phosphonic acid) hexasodium salt |
| phosphonic acid, p,p',p'',p'''-(1,2-ethanediylbis(nitrilobis(methylene)))tetrakis-, sodium salt (1:6) |
| ethylenediaminetetrakis(methylenephosphonic acid) hexasodium salt |
| einecs 239-204-1 |
| ethylene bis(nitrilodimethylene)tetraphosphonic acid, hexasodium salt |
| FT-0626290 |
| [1,2-ethanediylbis[nitrilobis-(methylene)]]tetrakis-phosphonic acid |
| ethylenediamine tetra(methylene phosphonic acid) |
| ethylenediamine-n,n,n',n'-tetra(methylphosphonic acid) |
| briquest 422-25s |
| ethanediylbis(nitrilobis-(methylene)))tetrakis-phosphonic acid, (1,2- |
| ph-540 |
| ph 540 |
| lexidronam |
| SCHEMBL22492 |
| DTXSID3061689 |
| ethylendiamintetra(methylenphosphonsaure) |
| NFDRPXJGHKJRLJ-UHFFFAOYSA-N |
| ethylenediamine tetramethylenephosphonic acid |
| n,n,n',n'-ethylenediaminetetra(methylenephosphonic acid) |
| mfcd00058893 |
| sr-01000944825 |
| SR-01000944825-1 |
| J-007725 |
| Q3045881 |
| E75876 |
| ((ethane-1,2-diylbis(azanetriyl))tetrakis(methylene))tetraphosphonic acid |
| AS-15020 |
| (ethane-1,2-diylbis(azanetriyl))tetrakis(methylene)tetraphosphonic acid |
| edtmp ,ethylenediamine tetrakis(methylene phosphonic acid) ,[2-[bis(phosphonomethyl)amino]ethyl-(phosphonomethyl)amino]methylphosphonic acid |
| CHEMBL1208647 |
| edtmpa |
| edtmp [1,2-ethanediylbis(nitrilobis-(methylene))]tetrakis-phosphonic acid |
| CS-W009667 |
| PD062904 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " Bone pain appears to be alleviated by 153Sm-EDTMP with limited red marrow doses and no toxic effects in other organs." | ( Dosimetry and toxicity of samarium-153-EDTMP administered for bone pain due to skeletal metastases. Bayouth, JE; Fossella, FV; Kasi, LP; Macey, DJ, 1994) | 0.29 |
| Excerpt | Reference | Relevance |
|---|---|---|
| " ADE studies revealed that [14C]EDITEMPA was poorly absorbed from the gastro-intestinal tract and that most of the absorbed dose was rapidly excreted by the kidneys or sequestered in bone." | ( Ethylenediaminetetra(methylenephosphonic acid): genotoxicity, biodistribution, and subchronic and chronic toxicity in rats. Anderson, RL; Balmbra, RR; Bhatt, A; Broadmeadow, A; Bruce, RD; Calvin, G; Long, PH; Miller, PM; Stitzel, KA, 1988) | 0.27 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " These radiation dose estimates permit patients at risk to be identified prior to reaching myelotoxicity and develop dose-response models." | ( Dosimetry and toxicity of samarium-153-EDTMP administered for bone pain due to skeletal metastases. Bayouth, JE; Fossella, FV; Kasi, LP; Macey, DJ, 1994) | 0.29 |
| "38% at a dosage of 5 mg/kg and 47." | ( A pilot study of antitumor effect of gallium ethylenediaminetetramethylene phosphonate [Ga(III)-EDTMP] in tumor-bearing rats. Jia, W; Qiu, Y; Su, M, ) | 0.13 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 13 (29.55) | 18.7374 |
| 1990's | 18 (40.91) | 18.2507 |
| 2000's | 7 (15.91) | 29.6817 |
| 2010's | 5 (11.36) | 24.3611 |
| 2020's | 1 (2.27) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (10.55) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (4.26%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 2 (4.26%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 43 (91.49%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||