cedrol profile

Cedrol is a naturally occurring sesquiterpene alcohol found in cedarwood oil. It is a bicyclic compound with a characteristic woody aroma. Cedrol is known for its antifungal and insecticidal properties, and it has been used traditionally in aromatherapy and as a fragrance ingredient. It is also used in the synthesis of other compounds, including cedrene and cedranol. Cedrol is studied for its potential therapeutic effects, including its anti-inflammatory, antioxidant, and antimicrobial activities. It is also being investigated for its role in plant defense mechanisms.'

cedrol: a cyclic terpenoid from cedarwood oil; 8-epicedrol is an epimer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	65575
CHEMBL ID	1974890
CHEBI ID	10217
SCHEMBL ID	107488
MeSH ID	M0210791

Synonym
[3r-(3alpha,3abeta,6alpha,7beta,8aalpha)]-octahydro-3,6,8,8-tetramethyl-1h-3a,7-methanoazulen-6-ol
CHEBI:10217 ,
(8r)-cedran-8-ol
8betah-cedran-8-ol
8.beta.h-cedran-8-ol
nsc46153
1h-3a, octahydro-3,6,8,8-tetramethyl-, [3r-(3.alpha.,3a.beta.,6.alpha.,7.beta.,8a.alpha.)]-
nsc-46153
(+)-cedrol
[3r-(3alpha,3abeta,6alpha,7beta,8aalpha)]-octa-hydro-3,6,8,8-tetramethyl-1h-3a,7-methanoazulen-6-ol
NCI60_003818
ai3-02178
(3r-(3alpha,3abeta,6alpha,7beta,8aalpha))-octahydro-3,6,8,8-tetramethyl-1h-3a,7-methanoazulen-6-ol
8-betah-cedran-8-ol
einecs 201-035-6
nsc 403883
cedrol (natural)
a-cedrol
NSC403883 ,
nsc-403883
cedrol
C09631
alpha-cedrol
77-53-2
cedrol, redistilled
(+)-cedrol, >=99.0% (sum of enantiomers, gc)
LMPR0103690007
hsdb 8265
63zm9703bo ,
unii-63zm9703bo
dtxsid1041269 ,
NCGC00260491-01
tox21_202945
cas-77-53-2
dtxcid9021269
AKOS024319138
bdbm50430739
(1s,2r,5s,7r,8r)-2,6,6,8-tetramethyltricyclo[5.3.1.01.5]undecan-8-ol
FT-0623526
cedar camphor
(3r-(3.alpha.,3a.beta.,6.alpha.,7.beta.,8a.alpha.))-octahydro-3,6,8,8-tetramethyl-1h-3a,7-methanoazulen-6-ol
cypress camphor
cedrol [mi]
cedrol [inci]
fema no. 4503
S4938
CHEMBL1974890 ,
SVURIXNDRWRAFU-OGMFBOKVSA-N
SCHEMBL107488
AC-34891
C2854
mfcd00062952
(+)-cedrol, analytical standard
(7beta,8alpha)-cedran-8-ol
(3r,3ar,6r,7r,8as)-3,6,8,8-tetramethyloctahydro-1h-3a,7-methanoazulen-6-ol
HY-N2071
AS-13700
Q1052617
cedrol-(+)
CCG-266739
CS-0018576
(1s,2r,5s,7r,8r)-2,6,6,8-tetramethyltricyclo[5.3.1.01,5]undecan-8-ol
(+)-cedrol;-cedrol
A865207
cedorol
1h-3a,7-methanoazulen-6-ol, octahydro-3,6,8,8-tetramethyl-,(3a,3ab,6a,7b,8aa)-
22567-44-8

Excerpt	Reference	Relevance
"Cedrol is an extremely versatile sesquiterpene alcohol that was approved by the Food and Drug Administration of the United States as a flavoring agent or adjuvant and has been commonly used as a flavoring ingredient in cosmetics, foods and medicine. "	( Characterization of a sesquiterpene cyclase from the glandular trichomes of Leucosceptrum canum for sole production of cedrol in Escherichia coli and Nicotiana benthamiana. Li, DS; Li, SH; Ling, Y; Liu, Y; Liu, YC; Luo, F; Tang, T, 2019)	2.17

Excerpt	Reference	Relevance
"Cedrol has been shown to exert anti-tumor, anti-inflammatory, and anti-oxidative effects, but its role in osteoarthritis (OA) is unclear. "	( Cedrol alleviates the apoptosis and inflammatory response of IL-1β-treated chondrocytes by promoting miR-542-5p expression. Dong, W; Li, S; Qian, W; Wang, P; Wang, S, 2021)	3.51

Excerpt	Reference	Relevance
" These include stability, dissolution rate, bioavailability and solubility, which can affect pharmacokinetics and pharmacodynamics."	( Anti-inflammatory and analgesic activity based on polymorphism of cedrol in mice. Chen, SS; Ding, M; Guan, J; Li, W; Su, GY; Wang, JW; Zhang, YM; Zhao, YQ, 2019)	0.75
" At the same time, the pharmacokinetic results showed that the absolute bioavailability of CE at 20, 40, and 80 mg/kg was 30."	( Cedrol from Ginger Ameliorates Rheumatoid Arthritis via Reducing Inflammation and Selectively Inhibiting JAK3 Phosphorylation. Guan, J; Li, W; Miao, DY; Shen, J; Wei, XR; Xie, YC; Zhang, YM; Zhao, JM; Zhao, YQ, 2021)	2.06

Excerpt	Relevance	Reference
" Black-legged tick nymphs exhibited dosage-dependent mortality when exposed to cedrol and at the highest dosage (i."	( Bioactivity of cedarwood oil and cedrol against arthropod pests. Behle, RW; Eller, FJ; Flor-Weiler, LB; Palmquist, DE; Vander Meer, RK, 2014)	0.91

Item	Process	Frequency
Huile essentielle	core-ingredient	1

Class	Description
cedrane sesquiterpenoid
tertiary alcohol	A tertiary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has three other carbon atoms attached to it.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
caspase 7, apoptosis-related cysteine protease	Homo sapiens (human)	Potency	68.4501	0.0133	26.9810	70.7614	AID1346978
nuclear receptor subfamily 1, group I, member 3	Homo sapiens (human)	Potency	34.3063	0.0010	22.6508	76.6163	AID1224839
estrogen-related nuclear receptor alpha	Homo sapiens (human)	Potency	54.3719	0.0015	30.6073	15,848.9004	AID1224841
caspase-3	Homo sapiens (human)	Potency	68.4501	0.0133	26.9810	70.7614	AID1346978
thyroid stimulating hormone receptor	Homo sapiens (human)	Potency	54.3719	0.0016	28.0151	77.1139	AID1224843; AID1224895
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	Homo sapiens (human)	Potency	54.8738	19.7391	45.9784	64.9432	AID1159509
v-jun sarcoma virus 17 oncogene homolog (avian)	Homo sapiens (human)	Potency	21.8456	0.0578	21.1097	61.2679	AID1159526; AID1159528
thyroid hormone receptor beta isoform 2	Rattus norvegicus (Norway rat)	Potency	57.6891	0.0003	23.4451	159.6830	AID743065; AID743067
heat shock protein beta-1	Homo sapiens (human)	Potency	61.5694	0.0420	27.3789	61.6448	AID743210; AID743228
nuclear factor erythroid 2-related factor 2 isoform 1	Homo sapiens (human)	Potency	64.6211	0.0006	27.2152	1,122.0200	AID743219
Cellular tumor antigen p53	Homo sapiens (human)	Potency	68.4501	0.0023	19.5956	74.0614	AID651631
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Alpha-glucosidase MAL62	Saccharomyces cerevisiae (brewer's yeast)	IC50 (µMol)	130,000.0000	0.8400	1.4200	2.0000	AID729970
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of cell population proliferation	Cellular tumor antigen p53	Homo sapiens (human)
regulation of cell cycle	Cellular tumor antigen p53	Homo sapiens (human)
regulation of cell cycle G2/M phase transition	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response	Cellular tumor antigen p53	Homo sapiens (human)
ER overload response	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to glucose starvation	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
regulation of apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of miRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
mitophagy	Cellular tumor antigen p53	Homo sapiens (human)
in utero embryonic development	Cellular tumor antigen p53	Homo sapiens (human)
somitogenesis	Cellular tumor antigen p53	Homo sapiens (human)
release of cytochrome c from mitochondria	Cellular tumor antigen p53	Homo sapiens (human)
hematopoietic progenitor cell differentiation	Cellular tumor antigen p53	Homo sapiens (human)
T cell proliferation involved in immune response	Cellular tumor antigen p53	Homo sapiens (human)
B cell lineage commitment	Cellular tumor antigen p53	Homo sapiens (human)
T cell lineage commitment	Cellular tumor antigen p53	Homo sapiens (human)
response to ischemia	Cellular tumor antigen p53	Homo sapiens (human)
nucleotide-excision repair	Cellular tumor antigen p53	Homo sapiens (human)
double-strand break repair	Cellular tumor antigen p53	Homo sapiens (human)
regulation of DNA-templated transcription	Cellular tumor antigen p53	Homo sapiens (human)
regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
protein import into nucleus	Cellular tumor antigen p53	Homo sapiens (human)
autophagy	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
transforming growth factor beta receptor signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
Ras protein signal transduction	Cellular tumor antigen p53	Homo sapiens (human)
gastrulation	Cellular tumor antigen p53	Homo sapiens (human)
neuroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of neuroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
protein localization	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of DNA replication	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of cell population proliferation	Cellular tumor antigen p53	Homo sapiens (human)
determination of adult lifespan	Cellular tumor antigen p53	Homo sapiens (human)
mRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
rRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
response to salt stress	Cellular tumor antigen p53	Homo sapiens (human)
response to inorganic substance	Cellular tumor antigen p53	Homo sapiens (human)
response to X-ray	Cellular tumor antigen p53	Homo sapiens (human)
response to gamma radiation	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of gene expression	Cellular tumor antigen p53	Homo sapiens (human)
cardiac muscle cell apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
glial cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
viral process	Cellular tumor antigen p53	Homo sapiens (human)
glucose catabolic process to lactate via pyruvate	Cellular tumor antigen p53	Homo sapiens (human)
cerebellum development	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of cell growth	Cellular tumor antigen p53	Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
mitotic G1 DNA damage checkpoint signaling	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of telomere maintenance via telomerase	Cellular tumor antigen p53	Homo sapiens (human)
T cell differentiation in thymus	Cellular tumor antigen p53	Homo sapiens (human)
tumor necrosis factor-mediated signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
regulation of tissue remodeling	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to UV	Cellular tumor antigen p53	Homo sapiens (human)
multicellular organism growth	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of mitochondrial membrane permeability	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to glucose starvation	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
entrainment of circadian clock by photoperiod	Cellular tumor antigen p53	Homo sapiens (human)
mitochondrial DNA repair	Cellular tumor antigen p53	Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of neuron apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
transcription initiation-coupled chromatin remodeling	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of proteolysis	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of DNA-templated transcription	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of DNA-templated transcription	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assembly	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of transcription by RNA polymerase II	Cellular tumor antigen p53	Homo sapiens (human)
response to antibiotic	Cellular tumor antigen p53	Homo sapiens (human)
fibroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of fibroblast proliferation	Cellular tumor antigen p53	Homo sapiens (human)
circadian behavior	Cellular tumor antigen p53	Homo sapiens (human)
bone marrow development	Cellular tumor antigen p53	Homo sapiens (human)
embryonic organ development	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylation	Cellular tumor antigen p53	Homo sapiens (human)
protein stabilization	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of helicase activity	Cellular tumor antigen p53	Homo sapiens (human)
protein tetramerization	Cellular tumor antigen p53	Homo sapiens (human)
chromosome organization	Cellular tumor antigen p53	Homo sapiens (human)
neuron apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
regulation of cell cycle	Cellular tumor antigen p53	Homo sapiens (human)
hematopoietic stem cell differentiation	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of glial cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
type II interferon-mediated signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
cardiac septum morphogenesis	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of programmed necrotic cell death	Cellular tumor antigen p53	Homo sapiens (human)
protein-containing complex assembly	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	Cellular tumor antigen p53	Homo sapiens (human)
thymocyte apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of thymocyte apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
necroptotic process	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to hypoxia	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to xenobiotic stimulus	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to ionizing radiation	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to gamma radiation	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to UV-C	Cellular tumor antigen p53	Homo sapiens (human)
stem cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
signal transduction by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
reactive oxygen species metabolic process	Cellular tumor antigen p53	Homo sapiens (human)
cellular response to actinomycin D	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondria	Cellular tumor antigen p53	Homo sapiens (human)
cellular senescence	Cellular tumor antigen p53	Homo sapiens (human)
replicative senescence	Cellular tumor antigen p53	Homo sapiens (human)
oxidative stress-induced premature senescence	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
oligodendrocyte apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of execution phase of apoptosis	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of mitophagy	Cellular tumor antigen p53	Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediator	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of miRNA transcription	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of G1 to G0 transition	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of miRNA processing	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvate	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of pentose-phosphate shunt	Cellular tumor antigen p53	Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxia	Cellular tumor antigen p53	Homo sapiens (human)
regulation of fibroblast apoptotic process	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of reactive oxygen species metabolic process	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of reactive oxygen species metabolic process	Cellular tumor antigen p53	Homo sapiens (human)
negative regulation of stem cell proliferation	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of cellular senescence	Cellular tumor antigen p53	Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathway	Cellular tumor antigen p53	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
transcription cis-regulatory region binding	Cellular tumor antigen p53	Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specific	Cellular tumor antigen p53	Homo sapiens (human)
cis-regulatory region sequence-specific DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
core promoter sequence-specific DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
TFIID-class transcription factor complex binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specific	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specific	Cellular tumor antigen p53	Homo sapiens (human)
protease binding	Cellular tumor antigen p53	Homo sapiens (human)
p53 binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA binding	Cellular tumor antigen p53	Homo sapiens (human)
chromatin binding	Cellular tumor antigen p53	Homo sapiens (human)
DNA-binding transcription factor activity	Cellular tumor antigen p53	Homo sapiens (human)
mRNA 3'-UTR binding	Cellular tumor antigen p53	Homo sapiens (human)
copper ion binding	Cellular tumor antigen p53	Homo sapiens (human)
protein binding	Cellular tumor antigen p53	Homo sapiens (human)
zinc ion binding	Cellular tumor antigen p53	Homo sapiens (human)
enzyme binding	Cellular tumor antigen p53	Homo sapiens (human)
receptor tyrosine kinase binding	Cellular tumor antigen p53	Homo sapiens (human)
ubiquitin protein ligase binding	Cellular tumor antigen p53	Homo sapiens (human)
histone deacetylase regulator activity	Cellular tumor antigen p53	Homo sapiens (human)
ATP-dependent DNA/DNA annealing activity	Cellular tumor antigen p53	Homo sapiens (human)
identical protein binding	Cellular tumor antigen p53	Homo sapiens (human)
histone deacetylase binding	Cellular tumor antigen p53	Homo sapiens (human)
protein heterodimerization activity	Cellular tumor antigen p53	Homo sapiens (human)
protein-folding chaperone binding	Cellular tumor antigen p53	Homo sapiens (human)
protein phosphatase 2A binding	Cellular tumor antigen p53	Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor binding	Cellular tumor antigen p53	Homo sapiens (human)
14-3-3 protein binding	Cellular tumor antigen p53	Homo sapiens (human)
MDM2/MDM4 family protein binding	Cellular tumor antigen p53	Homo sapiens (human)
disordered domain specific binding	Cellular tumor antigen p53	Homo sapiens (human)
general transcription initiation factor binding	Cellular tumor antigen p53	Homo sapiens (human)
molecular function activator activity	Cellular tumor antigen p53	Homo sapiens (human)
promoter-specific chromatin binding	Cellular tumor antigen p53	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
nuclear body	Cellular tumor antigen p53	Homo sapiens (human)
nucleus	Cellular tumor antigen p53	Homo sapiens (human)
nucleoplasm	Cellular tumor antigen p53	Homo sapiens (human)
replication fork	Cellular tumor antigen p53	Homo sapiens (human)
nucleolus	Cellular tumor antigen p53	Homo sapiens (human)
cytoplasm	Cellular tumor antigen p53	Homo sapiens (human)
mitochondrion	Cellular tumor antigen p53	Homo sapiens (human)
mitochondrial matrix	Cellular tumor antigen p53	Homo sapiens (human)
endoplasmic reticulum	Cellular tumor antigen p53	Homo sapiens (human)
centrosome	Cellular tumor antigen p53	Homo sapiens (human)
cytosol	Cellular tumor antigen p53	Homo sapiens (human)
nuclear matrix	Cellular tumor antigen p53	Homo sapiens (human)
PML body	Cellular tumor antigen p53	Homo sapiens (human)
transcription repressor complex	Cellular tumor antigen p53	Homo sapiens (human)
site of double-strand break	Cellular tumor antigen p53	Homo sapiens (human)
germ cell nucleus	Cellular tumor antigen p53	Homo sapiens (human)
chromatin	Cellular tumor antigen p53	Homo sapiens (human)
transcription regulator complex	Cellular tumor antigen p53	Homo sapiens (human)
protein-containing complex	Cellular tumor antigen p53	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (309)

Assay ID	Title	Year	Journal	Article
AID1697651	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as CyclinA expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697475	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697510	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1082715	Antifungal activity against Lenzites betulinus BCRC 35296 assessed as reduction of fungi mycelium growth at 100 ug/ml	2012	Journal of agricultural and food chemistry, Jan-11, Volume: 60, Issue:1	Phytochemicals from Cunninghamia konishii Hayata act as antifungal agents.
AID1697580	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G2/M phase at 112.4 uM after 24 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 30.08 +/- 0.1%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697515	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 89.9 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697509	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697595	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G2/M phase at 112.4 uM after 48 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 30.08 +/- 0.1%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697747	Induction of apoptosis in human DBTRG-05MG cells assessed as cleaved PARP expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697832	Inhibition of TMZ-induced drug resistance in rat RG2 cells assessed as CD133 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 2.4 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697703	Inhibition of ERK phosphorylation at Tyr204 residues in rat RG2 cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697546	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 89.9 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697585	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at S phase at 112.4 uM after 24 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 22.76 +/- 1.56%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697676	Effect on JNK expression in human DBTRG-05MG cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697621	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at S phase at 112.4 uM after 24 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 20.15 +/- 2.44%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697781	Induction of apoptosis in rat RG2 cells assessed as Bax expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697737	Induction of apoptosis in rat RG2 cells assessed as increase in chromatin condensation at 112.4 uM after 48 hrs in presence of TMZ by TUNEL assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697611	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G0/G1 phase at 112.4 uM after 12 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 57.81 +/- 1.9%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697462	Cytotoxicity against human DBTRG-05MG cells assessed as reduction in cell viability after 72 hrs by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697576	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at S phase at 112.4 uM after 12 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 22.76 +/- 1.56%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697810	Induction of DNA damage in human DBTRG-05MG cells assessed as ATM phosphorylation at ser1981 residues at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697487	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 89.9 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697570	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at S phase at 112.4 uM after 12 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 22.76 +/- 1.56%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697812	Induction of DNA damage in human DBTRG-05MG cells assessed as ATR phosphorylation at ser428 residues at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697514	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697633	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as p21 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID729970	Inhibition of yeast alpha-glucosidase using para-nitrophenyl alpha-D-glucopyranoside as substrate by spectrophotometric analysis	2013	European journal of medicinal chemistry, Apr, Volume: 62	Fungal transformation of cedryl acetate and α-glucosidase inhibition assay, quantum mechanical calculations and molecular docking studies of its metabolites.
AID1697540	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697839	Potentiation of TMZ-induced antitumor activity against human DBTRG-05MG cells xenografted in BALB/c nude mouse assessed as increase in survival time at 75 mg/kg, sc co-treated with TMZ for 18 days	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697693	Inhibition of JNK phosphorylation at Thr183/Tyr185 residues in human DBTRG-05MG cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697605	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G0/G1 phase at 112.4 uM after 12 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 57.81 +/- 1.9%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697794	Induction of DNA damage in human DBTRG-05MG cells assessed as Chk1 phosphorylation at ser345 residues at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697472	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697587	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G0/G1 phase at 112.4 uM after 48 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 47.16 +/- 1.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697476	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697845	Potentiation of TMZ-induced antitumor activity against human DBTRG-05MG cells xenografted in BALB/c nude mouse assessed as reduction in MGMT expression at 75 mg/kg, sc co-treated with TMZ for 18 days by fluorescent immunocytochemistry method	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697734	Induction of apoptosis in human DBTRG-05MG cells assessed as increase in chromatin condensation at 112.4 uM after 48 hrs in presence of TMZ by TUNEL assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697847	Toxicity in BALB/c mouse xenografted with DBTRG-05MG cells assessed as inflammatory cell infiltration score in liver at at 5 mg/kg, ip for 5 days by H and E staining-based bright field microscopic analysis	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697615	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at S phase at 112.4 uM after 24 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 20.15 +/- 2.44%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697520	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 112.4 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697657	Induction of cell cycle arrest in rat RG2 cells assessed as CDK2 expression at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697537	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697548	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 89.9 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697795	Induction of DNA damage in rat RG2 cells assessed as Chk1 phosphorylation at ser345 at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697616	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G2/M phase at 112.4 uM after 24 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 20.04 +/- 0.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697718	Effect on ERK expression in rat RG2 cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697513	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697780	Induction of apoptosis in rat RG2 cells assessed as Bcl2 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697648	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as CDK4 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697512	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697698	Effect on AKT expression in rat RG2 cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697571	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G2/M phase at 112.4 uM after 12 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 30.08 +/- 0.1%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697525	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 134.9 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697697	Inhibition of p38 phosphorylation at Tyr182 residues in human DBTRG-05MG cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697504	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697652	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as CyclinB1 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697758	Induction of apoptosis in human DBTRG-05MG cells assessed as phosphorylated caspace-9 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1082713	Antifungal activity against Laetiporus sulphureus BCRC 35305 (wood decay fungi) assessed as reduction of fungi mycelium growth at 100 ug/ml	2012	Journal of agricultural and food chemistry, Jan-11, Volume: 60, Issue:1	Phytochemicals from Cunninghamia konishii Hayata act as antifungal agents.
AID1697825	Effect of MGMT expression in rat RG2 cells at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697786	Induction of apoptosis in rat RG2 cells assessed as phosphorylated PARP expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1082712	Antifungal activity against Gloeophyllum trabeum BCRC 31614 (wood decay fungi) assessed as reduction of fungi mycelium growth at 100 ug/ml	2012	Journal of agricultural and food chemistry, Jan-11, Volume: 60, Issue:1	Phytochemicals from Cunninghamia konishii Hayata act as antifungal agents.
AID1697539	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697588	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at S phase at 112.4 uM after 48 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 22.76 +/- 1.56%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697464	Cytotoxicity against rat RG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697545	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 89.9 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697736	Induction of apoptosis in human DBTRG-05MG cells assessed as increase in apoptotic body formation at 112.4 uM after 48 hrs in presence of TMZ by TUNEL assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697460	Cytotoxicity against human DBTRG-05MG cells assessed as reduction in cell viability after 24 hrs by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697843	Potentiation of TMZ-induced antitumor activity against human DBTRG-05MG cells xenografted in BALB/c nude mouse assessed as increase in apoptotic cells at 75 mg/kg, sc co-treated with TMZ for 18 days by TUNEL assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697543	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697473	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697490	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 112.4 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697824	Effect of MDR1 expression in human DBTRG-05MG cells at 112.4 uM after 48 hrs by Western blot analysis	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697714	Effect on AKT expression in rat RG2 cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697783	Induction of apoptosis in rat RG2 cells assessed as cleaved caspace-9 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697704	Effect on p38 expression in rat RG2 cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697827	Effect of MDR1 expression in rat RG2 cells at 112.4 uM after 48 hrs by Western blot analysis	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697579	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at S phase at 112.4 uM after 24 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 22.76 +/- 1.56%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697631	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G2/M phase at 112.4 uM after 48 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 20.04 +/- 0.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697523	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 112.4 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697507	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697519	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 89.9 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697715	Inhibition of AKT phosphorylation at S473 residues in rat RG2 cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697759	Induction of apoptosis in human DBTRG-05MG cells assessed as cleaved caspace-9 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697532	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697526	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 134.9 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697835	Antitumour activity against human DBTRG-05MG cells xenografted in BALB/c nude mouse assessed as reduction in tumour growth at 75 mg/kg, sc for every 2 days for 20 days and measured every 2 days	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697494	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 112.4 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697521	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 112.4 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697817	Induction of DNA damage in rat RG2 cells assessed as Chk2 phosphorylation at Thr68 at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697637	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as CyclinA expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697671	Induction of cell cycle arrest in rat RG2 cells assessed as CDK2 expression at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697556	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 134.9 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697767	Induction of apoptosis in rat RG2 cells assessed as cleaved caspace-9 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697465	Cytotoxicity against rat RG2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697649	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as CyclinD1 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697461	Cytotoxicity against human DBTRG-05MG cells assessed as reduction in cell viability after 48 hrs by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697691	Inhibition of AKT phosphorylation at S473 residues in human DBTRG-05MG cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697530	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697846	Toxicity in BALB/c mouse xenografted with DBTRG-05MG cells assessed as inflammatory cell infiltration score in liver at at 75 mg/kg, sc co-treated with TMZ for 18 days by H and E staining-based bright field microscopic analysis	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697578	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G0/G1 phase at 112.4 uM after 24 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 47.16 +/- 1.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697484	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697468	Cytotoxicity against rat CTX TNA2 cells assessed as reduction in cell viability after 72 hrs by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697614	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G0/G1 phase at 112.4 uM after 24 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 57.81 +/- 1.9%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697496	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 134.9 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697508	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697692	Effect on JNK expression in human DBTRG-05MG cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697562	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G2/M phase at 112.4 uM after 6 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 30.08 +/- 0.1%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697792	Induction of DNA damage in human DBTRG-05MG cells assessed as ATR phosphorylation at ser428 residues at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697646	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as p53 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697656	Induction of cell cycle arrest in rat RG2 cells assessed as CyclinD1 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697561	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at S phase at 112.4 uM after 6 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 22.76 +/- 1.56%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697726	Induction of apoptosis in rat RG2 cells assessed as increase in DNA fragmentation at 112.4 uM after 48 hrs by TUNEL assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697506	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697603	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at S phase at 112.4 uM after 6 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 20.15 +/- 2.44%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697613	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G2/M phase at 112.4 uM after 12 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 20.04 +/- 0.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697629	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G0/G1 phase at 112.4 uM after 48 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 57.81 +/- 1.9%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697638	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as CyclinB1 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697569	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G0/G1 phase at 112.4 uM after 12 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 47.16 +/- 1.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697764	Induction of apoptosis in rat RG2 cells assessed as Bcl2 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697680	Effect on p38 expression in human DBTRG-05MG cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697480	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697668	Induction of cell cycle arrest in rat RG2 cells assessed as p21 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697466	Cytotoxicity against rat CTX TNA2 cells assessed as reduction in cell viability after 24 hrs by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697559	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 134.9 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697566	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G0/G1 phase at 112.4 uM after 6 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 47.16 +/- 1.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697555	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 134.9 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697745	Induction of apoptosis in human DBTRG-05MG cells assessed as cleaved caspace-3 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID977599	Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM	2013	Molecular pharmacology, Jun, Volume: 83, Issue:6	Structure-based identification of OATP1B1/3 inhibitors.
AID1697541	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697650	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as CDK2 expression at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697788	Induction of DNA damage in human DBTRG-05MG cells at 112.4 uM after 48 hrs in presence of TMZ by p.H2A.X staining based fluorescent immunocytochemistry method	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697744	Induction of apoptosis in human DBTRG-05MG cells assessed as phosphorylated caspace-3 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697669	Induction of cell cycle arrest in rat RG2 cells assessed as CDK4 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697675	Inhibition of AKT phosphorylation at S473 residues in human DBTRG-05MG cells at 112.4uM after 48 hrs by Western blot analysis	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697636	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as CDK2 expression at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697635	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as CyclinD1 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697499	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 134.9 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697482	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697459	Toxicity in BALB/c mouse xenografted with DBTRG-05MG cells assessed as reduction in body weight at 75 mg/kg, sc for every 2 days for 20 days	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697757	Induction of apoptosis in human DBTRG-05MG cells assessed as Bax expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697836	Potentiation of TMZ-induced antitumor activity against human DBTRG-05MG cells xenografted in BALB/c nude mouse assessed as reduction in tumour growth at 75 mg/kg, sc co-treated with TMZ for 18 days	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697819	Induction of DNA damage in rat RG2 cells assessed as H2A.X phosphorylation at ser139 at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697782	Induction of apoptosis in rat RG2 cells assessed as phosphorylated caspace-9 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697554	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 112.4 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697534	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697741	Induction of apoptosis in human DBTRG-05MG cells assessed as Bax expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697791	Induction of DNA damage in rat RG2 cells assessed as ATM phosphorylation at ser1981 residues at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697517	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 89.9 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697784	Induction of apoptosis in rat RG2 cells assessed as phosphorylated caspace-3 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697495	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 134.9 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697721	Inhibition of p38 phosphorylation at Tyr182 residues in rat RG2 cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697584	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G0/G1 phase at 112.4 uM after 24 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 47.16 +/- 1.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697769	Induction of apoptosis in rat RG2 cells assessed as cleaved caspace-3 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697560	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G0/G1 phase at 112.4 uM after 6 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 47.16 +/- 1.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697577	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G2/M phase at 112.4 uM after 12 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 30.08 +/- 0.1%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697485	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 89.9 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697743	Induction of apoptosis in human DBTRG-05MG cells assessed as cleaved caspace-9 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697511	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697589	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G2/M phase at 112.4 uM after 48 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 30.08 +/- 0.1%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697593	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G0/G1 phase at 112.4 uM after 48 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 47.16 +/- 1.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697612	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at S phase at 112.4 uM after 12 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 20.15 +/- 2.44%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697673	Induction of cell cycle arrest in rat RG2 cells assessed as CyclinB1 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697678	Effect on ERK expression in human DBTRG-05MG cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697535	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697798	Induction of DNA damage in human DBTRG-05MG cells assessed as H2A.X phosphorylation at ser139 residues at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697746	Induction of apoptosis in human DBTRG-05MG cells assessed as phosphorylated PARP expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697478	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697606	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at S phase at 112.4 uM after 12 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 20.15 +/- 2.44%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697695	Inhibition of ERK phosphorylation at Tyr204 residues in human DBTRG-05MG cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697722	Induction of apoptosis in human DBTRG-05MG cells assessed as increase in chromatin condensation at 112.4 uM after 48 hrs by TUNEL assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697702	Effect on ERK expression in rat RG2 cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697826	Effect of CD133 expression in rat RG2 cells at 112.4 uM after 48 hrs by Western blot analysis	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697497	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 134.9 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697793	Induction of DNA damage in rat RG2 cells assessed as ATR phosphorylation at ser428 residues at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697659	Induction of cell cycle arrest in rat RG2 cells assessed as CyclinB1 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697492	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 112.4 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697568	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G2/M phase at 112.4 uM after 6 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 30.08 +/- 0.1%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697575	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G0/G1 phase at 112.4 uM after 12 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 47.16 +/- 1.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697586	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at G2/M phase at 112.4 uM after 24 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 30.08 +/- 0.1%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697481	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697742	Induction of apoptosis in human DBTRG-05MG cells assessed as phosphorylated caspace-9 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697672	Induction of cell cycle arrest in rat RG2 cells assessed as CyclinA expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697833	Inhibition of TMZ-induced drug resistance in rat RG2 cells assessed as MDR1 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 5.3 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697842	Potentiation of TMZ-induced antitumor activity against human DBTRG-05MG cells xenografted in BALB/c nude mouse assessed as reduction in tumor growth at 75 mg/kg, sc co-treated with TMZ for 18 days by PCNA staining-based bright field microscopic analysis	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697483	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697620	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G0/G1 phase at 112.4 uM after 24 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 57.81 +/- 1.9%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697533	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697502	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697830	Inhibition of TMZ-induced drug resistance in human DBTRG-05MG cells assessed as MDR1 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1.5 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697463	Cytotoxicity against rat RG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697756	Induction of apoptosis in human DBTRG-05MG cells assessed as Bcl2 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697670	Induction of cell cycle arrest in rat RG2 cells assessed as CyclinD1 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697527	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 134.9 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697594	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at S phase at 112.4 uM after 48 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 22.76 +/- 1.56%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697677	Inhibition of JNK phosphorylation at Thr183/Tyr185 residues in human DBTRG-05MG cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697655	Induction of cell cycle arrest in rat RG2 cells assessed as CDK4 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697735	Induction of apoptosis in human DBTRG-05MG cells assessed as increase in DNA fragmentation at 112.4 uM after 48 hrs in presence of TMZ by TUNEL assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697823	Effect of CD133 expression in human DBTRG-05MG cells at 112.4 uM after 48 hrs by Western blot analysis	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697724	Induction of apoptosis in human DBTRG-05MG cells assessed as increase in apoptotic body formation at 112.4 uM after 48 hrs by TUNEL assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697796	Induction of DNA damage in human DBTRG-05MG cells assessed as Chk2 phosphorylation at Thr68 residues at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697505	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697815	Induction of DNA damage in rat RG2 cells assessed as Chk1 phosphorylation at ser345 at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697602	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G0/G1 phase at 112.4 uM after 6 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 57.81 +/- 1.9%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697597	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at S phase at 112.4 uM after 6 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 20.15 +/- 2.44%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697763	Induction of apoptosis in human DBTRG-05MG cells assessed as cleaved PARP expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697489	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 89.9 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697844	Potentiation of TMZ-induced antitumor activity against human DBTRG-05MG cells xenografted in BALB/c nude mouse assessed as increase DNA damage at 75 mg/kg, sc co-treated with TMZ for 18 days by p.H2A.X staining based fluorescent immunocytochemistry method	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697816	Induction of DNA damage in human DBTRG-05MG cells assessed as Chk2 phosphorylation at Thr68 residues at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697653	Induction of cell cycle arrest in rat RG2 cells assessed as p53 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697701	Inhibition of JNK phosphorylation at Thr183/Tyr185 residues in rat RG2 cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697654	Induction of cell cycle arrest in rat RG2 cells assessed as p21 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697467	Cytotoxicity against rat CTX TNA2 cells assessed as reduction in cell viability after 48 hrs by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697740	Induction of apoptosis in human DBTRG-05MG cells assessed as Bcl2 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697531	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697762	Induction of apoptosis in human DBTRG-05MG cells assessed as phosphorylated PARP expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697486	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 89.9 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697479	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697811	Induction of DNA damage in rat RG2 cells assessed as ATM phosphorylation at ser1981 residues at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697518	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 89.9 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697723	Induction of apoptosis in human DBTRG-05MG cells assessed as increase in DNA fragmentation at 112.4 uM after 48 hrs by TUNEL assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697838	Antitumour activity against human DBTRG-05MG cells xenografted in BALB/c nude mouse assessed as increase in survival time at 75 mg/kg, sc for every 2 days for 20 days and measured every 2 days	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697799	Induction of DNA damage in rat RG2 cells assessed as H2A.X phosphorylation at ser139 at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697596	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G0/G1 phase at 112.4 uM after 6 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 57.81 +/- 1.9%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697553	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 112.4 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697679	Inhibition of ERK phosphorylation at Tyr204 residues in human DBTRG-05MG cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697488	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 89.9 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697491	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 112.4 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697690	Effect on AKT expression in human DBTRG-05MG cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697528	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 134.9 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697552	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 112.4 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697696	Effect on p38 expression in human DBTRG-05MG cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697604	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G2/M phase at 112.4 uM after 6 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 20.04 +/- 0.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697789	Induction of DNA damage in rat RG2 cells at 112.4 uM after 48 hrs in presence of TMZ by p.H2A.X staining based fluorescent immunocytochemistry method	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697551	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 112.4 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697623	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G0/G1 phase at 112.4 uM after 48 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 57.81 +/- 1.9%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697647	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as p21 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697634	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as CDK4 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697630	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at S phase at 112.4 uM after 48 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 20.15 +/- 2.44%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697771	Induction of apoptosis in rat RG2 cells assessed as cleaved PARP expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697820	Inhibition of TMZ-induced drug resistance in human DBTRG-05MG cells assessed as reduction in MGMT protein expression at 112.4 uM after 48 hrs by Immunohistochemistry method	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697694	Effect on ERK expression in human DBTRG-05MG cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697717	Inhibition of JNK phosphorylation at Thr183/Tyr185 residues in rat RG2 cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697797	Induction of DNA damage in rat RG2 cells assessed as Chk2 phosphorylation at Thr68 at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID977602	Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM	2013	Molecular pharmacology, Jun, Volume: 83, Issue:6	Structure-based identification of OATP1B1/3 inhibitors.
AID1697841	Potentiation of TMZ-induced antitumor activity against human DBTRG-05MG cells xenografted in BALB/c nude mouse assessed as reduction in tumor growth at 75 mg/kg, sc co-treated with TMZ for 18 days by H and E staining-based bright field microscopic analysi	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697727	Induction of apoptosis in rat RG2 cells assessed as increase in apoptotic body formation at 112.4 uM after 48 hrs by TUNEL assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697785	Induction of apoptosis in rat RG2 cells assessed as cleaved caspace-3 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697719	Inhibition of ERK phosphorylation at Tyr204 residues in rat RG2 cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697622	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G2/M phase at 112.4 uM after 24 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 20.04 +/- 0.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697828	Inhibition of TMZ-induced drug resistance in human DBTRG-05MG cells assessed as MGMT expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1.3 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697765	Induction of apoptosis in rat RG2 cells assessed as Bax expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697831	Inhibition of TMZ-induced drug resistance in rat RG2 cells assessed as MGMT expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 2 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697766	Induction of apoptosis in rat RG2 cells assessed as phosphorylated caspace-9 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697471	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697607	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G2/M phase at 112.4 uM after 12 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 20.04 +/- 0.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697725	Induction of apoptosis in rat RG2 cells assessed as increase in chromatin condensation at 112.4 uM after 48 hrs by TUNEL assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697761	Induction of apoptosis in human DBTRG-05MG cells assessed as cleaved caspace-3 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697522	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 112.4 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697474	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697598	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G2/M phase at 112.4 uM after 6 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 20.04 +/- 0.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697524	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 112.4 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697500	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697470	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697550	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 112.4 uM after 48 hrs in presence of 103 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697705	Inhibition of p38 phosphorylation at Tyr182 residues in rat RG2 cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697493	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 112.4 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697700	Effect on JNK expression in rat RG2 cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697549	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 89.9 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1082714	Antifungal activity against Trametes versicolor BCRC 35253 wood decay fungi assessed as reduction of fungi mycelium growth at 100 ug/ml	2012	Journal of agricultural and food chemistry, Jan-11, Volume: 60, Issue:1	Phytochemicals from Cunninghamia konishii Hayata act as antifungal agents.
AID1697768	Induction of apoptosis in rat RG2 cells assessed as phosphorylated caspace-3 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697813	Induction of DNA damage in rat RG2 cells assessed as ATR phosphorylation at ser428 residues at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697674	Effect on AKT expression in human DBTRG-05MG cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697716	Effect on JNK expression in rat RG2 cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697547	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 89.9 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697658	Induction of cell cycle arrest in rat RG2 cells assessed as CyclinA expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697770	Induction of apoptosis in rat RG2 cells assessed as phosphorylated PARP expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697498	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as combination index at 134.9 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697790	Induction of DNA damage in human DBTRG-05MG cells assessed as ATM phosphorylation at ser1981 residues at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697538	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697529	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 134.9 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697814	Induction of DNA damage in human DBTRG-05MG cells assessed as Chk1 phosphorylation at ser345 residues at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697536	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697477	Synergistic cytotoxicity against human DBTRG-05MG cells assessed as synergistic effect index at 112.4 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697544	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 515.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697503	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697822	Effect of MGMT expression in human DBTRG-05MG cells at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697829	Inhibition of TMZ-induced drug resistance in human DBTRG-05MG cells assessed as CD133 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 2.3 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697699	Inhibition of AKT phosphorylation at S473 residues in rat RG2 cells at 112.4uM after 48 hrs by Western blot analysis	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697681	Inhibition of p38 phosphorylation at Tyr182 residues in human DBTRG-05MG cells at 112.4uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697624	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at S phase at 112.4 uM after 48 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 20.15 +/- 2.44%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697557	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 134.9 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697567	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as accumulation at S phase at 112.4 uM after 6 hrs in presence of TMZ by propidium iodide staining based flow cytometric analysis (Rvb = 22.76 +/- 1.56%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697787	Induction of apoptosis in rat RG2 cells assessed as cleaved PARP expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697760	Induction of apoptosis in human DBTRG-05MG cells assessed as phosphorylated caspace-3 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697738	Induction of apoptosis in rat RG2 cells assessed as increase in DNA fragmentation at 112.4 uM after 48 hrs in presence of TMZ by TUNEL assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697516	Synergistic cytotoxicity against rat RG2 cells assessed as combination index at 89.9 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697818	Induction of DNA damage in human DBTRG-05MG cells assessed as H2A.X phosphorylation at ser139 residues at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697632	Induction of cell cycle arrest in human DBTRG-05MG cells assessed as p53 expression at 112.4 uM after 48 hrs by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697501	Synergistic cytotoxicity against rat RG2 cells assessed as synergistic effect index at 89.9 uM after 48 hrs in presence of 206 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697840	Toxicity in BALB/c mouse xenografted with DBTRG-05MG cells assessed as reduction in body weight at 75 mg/kg, sc for 18 days co-treated with TMZ	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697720	Effect on p38 expression in rat RG2 cells at 112.4uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697558	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as combination index at 134.9 uM after 48 hrs in presence of 412.1 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697625	Induction of cell cycle arrest in rat RG2 cells assessed as accumulation at G2/M phase at 112.4 uM after 48 hrs by propidium iodide staining based flow cytometric analysis (Rvb = 20.04 +/- 0.55%)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697542	Synergistic cytotoxicity against rat CTX TNA2 cells assessed as synergistic effect index at 134.9 uM after 48 hrs in presence of 309 uM TMZ by MTT assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697667	Induction of cell cycle arrest in rat RG2 cells assessed as p53 expression at 112.4 uM after 48 hrs in presence of TMZ by Western blot analysis (Rvb = 1 No_unit)	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697739	Induction of apoptosis in rat RG2 cells assessed as increase in apoptotic body formation at 112.4 uM after 48 hrs in presence of TMZ by TUNEL assay	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1697821	Inhibition of TMZ-induced drug resistance in rat RG2 cells assessed as reduction in MGMT protein expression at 112.4 uM after 48 hrs by Immunohistochemistry method	2020	Journal of natural products, 10-23, Volume: 83, Issue:10	Cedrol, a Sesquiterpene Alcohol, Enhances the Anticancer Efficacy of Temozolomide in Attenuating Drug Resistance via Regulation of the DNA Damage Response and MGMT Expression.
AID1224817	Assays to identify small molecules inhibitory for eIF4E expression	2015	Chemistry & biology, Jul-23, Volume: 22, Issue:7	Internal Ribosome Entry Site-Based Bicistronic In Situ Reporter Assays for Discovery of Transcription-Targeted Lead Compounds.
AID1159550	Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening	2015	Nature cell biology, Nov, Volume: 17, Issue:11	6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (5.26)	18.2507
2000's	9 (15.79)	29.6817
2010's	29 (50.88)	24.3611
2020's	16 (28.07)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	1 (1.69%)	5.53%
Reviews	3 (5.08%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	55 (93.22%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
2-(3-pyridine)acetic acid 3-pyridylacetic acid : A monocarboxylic acid that is acetic acid substituted by a (pyridin-3-yl) group. It is a metabolite of nicotine and other tobacco alkaloids.	2.11	1	monocarboxylic acid; pyridines	human xenobiotic metabolite
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	2.21	1	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
ureidosuccinic acid ureidosuccinic acid: RN given refers to (DL)-isomer. N-carbamoylaspartic acid : An N-carbamoylamino acid that is aspartic acid with one of its amino hydrogens replaced by a carbamoyl group.	2.11	1	aspartic acid derivative; C4-dicarboxylic acid; N-carbamoyl-amino acid	Escherichia coli metabolite; human metabolite; Saccharomyces cerevisiae metabolite
arabinofuranosylcytosine triphosphate [no description available]	2.11	1	pyrimidine ribonucleoside monophosphate
aminoethylphosphonic acid Aminoethylphosphonic Acid: An organophosphorus compound isolated from human and animal tissues.. (2-aminoethyl)phosphonic acid : A phosphonic acid in which the hydrogen attached to the phosphorus of phosphonic acid is substituted by a 2-aminoethyl group.	2.11	1	phosphonic acids; primary amino compound; zwitterion	human metabolite; metabolite; mouse metabolite
gamma-guanidinobutyric acid gamma-guanidinobutyric acid: RN given refers to parent cpd. 4-guanidinobutyric acid : A monocarboxylic acid that is butanoic acid substituted by a guanidino group at position 4.. 4-guanidinobutanoate : A monocarboxylic acid anion that is the conjugate base of 4-guanidinobutanoic acid.. 4-guanidinobutanoic acid : The 4-guanidino derivative of butanoic acid.	2.11	1	guanidines; monocarboxylic acid; zwitterion	fungal metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
3,4-dihydroxyphenylacetic acid 3,4-Dihydroxyphenylacetic Acid: A deaminated metabolite of LEVODOPA.. (3,4-dihydroxyphenyl)acetic acid : A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.. dihydroxyphenylacetic acid : A dihydroxy monocarboxylic acid consisting of phenylacetic acid having two phenolic hydroxy substituents.	2.59	2	catechols; dihydroxyphenylacetic acid	human metabolite
inositol Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.. inositol : Any cyclohexane-1,2,3,4,5,6-hexol.. 1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.. muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.	2.11	1	cyclitol; hexol
pentachlorophenol PENTA: structure given in first source	2.11	1	aromatic fungicide; chlorophenol; organochlorine pesticide; pentachlorobenzenes	human xenobiotic metabolite
phenylalanine [no description available]	2.11	1	alpha-amino acid; aromatic amino acid	Daphnia magna metabolite
nsc-267703 [no description available]	2.11	1	anthracycline
homovanillic acid Homovanillic Acid: A 3-O-methyl ETHER of (3,4-dihydroxyphenyl)acetic acid.. homovanillate : A hydroxy monocarboxylic acid anion which is obtained by deprotonation of the carboxy group of homovanillic acid.. homovanillic acid : A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.	2.21	1	guaiacols; monocarboxylic acid	human metabolite; mouse metabolite
hydroxyindoleacetic acid (5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.	2.59	2	indole-3-acetic acids	drug metabolite; human metabolite; mouse metabolite
n-acetyltryptophan N-acetyltryptophan : An N-acetylamino acid that is the N-acetyl derivative of tryptophan.	2.11	1	N-acetyl-amino acid; tryptophan derivative	metabolite
tyrphostin ag957 tyrphostin AG957: tyrosine kinase blocker; structure given in first source	2.11	1	aromatic amine
2-amino-4-phosphonobutyric acid 2-amino-4-phosphonobutyric acid: glutamate antagonist in locust muscle; structure; do not confuse with L-AP4, which is the propionic acid version	2.11	1
aristolochic acid i aristolochic acid I: phospholipase A inhibitor. aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.	2.11	1	aristolochic acids; aromatic ether; C-nitro compound; cyclic acetal; monocarboxylic acid; organic heterotetracyclic compound	carcinogenic agent; metabolite; mutagen; nephrotoxin; toxin
aspirin Aspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5). acetylsalicylate : A benzoate that is the conjugate base of acetylsalicylic acid, arising from deprotonation of the carboxy group.. acetylsalicylic acid : A member of the class of benzoic acids that is salicylic acid in which the hydrogen that is attached to the phenolic hydroxy group has been replaced by an acetoxy group. A non-steroidal anti-inflammatory drug with cyclooxygenase inhibitor activity.	2.05	1	benzoic acids; phenyl acetates; salicylates	anticoagulant; antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; drug allergen; EC 1.1.1.188 (prostaglandin-F synthase) inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug; plant activator; platelet aggregation inhibitor; prostaglandin antagonist; teratogenic agent
benzbromarone Benzbromarone: Uricosuric that acts by increasing uric acid clearance. It is used in the treatment of gout.. benzbromarone : 1-Benzofuran substituted at C-2 and C-3 by an ethyl group and a 3,5-dibromo-4-hydroxybenzoyl group respectively. An inhibitor of CYP2C9, it is used as an anti-gout medication.	2.11	1	1-benzofurans; aromatic ketone	uricosuric drug
benzylhydrochlorothiazide [no description available]	2.11	1	benzenes; benzothiadiazine; organochlorine compound; secondary amino compound; sulfonamide
eucalyptol [no description available]	2.11	1
amberlite cg 400 [no description available]	2.11	1	methyl ester; organic heteropentacyclic compound; yohimban alkaloid
stallimycin [no description available]	2.11	1
domperidone Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.. domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.	2.11	1	benzimidazoles; heteroarylpiperidine	antiemetic; dopaminergic antagonist
ellipticine ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.	2.11	1	indole alkaloid; organic heterotetracyclic compound; organonitrogen heterocyclic compound; polycyclic heteroarene	antineoplastic agent; plant metabolite
glyphosate glyphosate: active cpd in herbicidal formulation Roundup; inhibits EC 2.5.1.19, 5-enolpyruvylshikimate-3-phosphate synthase; structure. glyphosate : A phosphonic acid resulting from the formal oxidative coupling of the methyl group of methylphosphonic acid with the amino group of glycine. It is one of the most commonly used herbicides worldwide, and the only one to target the enzyme 5-enolpyruvyl-3-shikimate phosphate synthase (EPSPS).	2.11	1	glycine derivative; phosphonic acid	agrochemical; EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor; herbicide
haloperidol Haloperidol: A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279). haloperidol : A compound composed of a central piperidine structure with hydroxy and p-chlorophenyl substituents at position 4 and an N-linked p-fluorobutyrophenone moiety.	2.11	1	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist
miltefosine miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.	2.11	1	phosphocholines; phospholipid	anti-inflammatory agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antiprotozoal drug; apoptosis inducer; immunomodulator; protein kinase inhibitor
hypericin [no description available]	2.11	1
batyl alcohol batyl alcohol: RN given refers to cpd without isomeric designation. batilol : An alkylglycerol that is glycerol in which one of the primary hydroxy groups has been converted into the corresponding octadecyl ether. It is used in cosmetics as a stabilising ingredient and skin-conditioning agent.	2.11	1	alkylglycerol
imipramine Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.. imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.	2.11	1	dibenzoazepine	adrenergic uptake inhibitor; antidepressant; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.41	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
nsc 664704 kenpaullone: inhibits CDK1/cyclin B; structure in first source. kenpaullone : An indolobenzazepine that is paullone in which the hydrogen at position 9 is replaced by a bromo substituent. It is an ATP-competitive inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3beta (GSK3beta).	2.11	1	indolobenzazepine; lactam; organobromine compound	cardioprotective agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor; EC 2.7.11.26 (tau-protein kinase) inhibitor; geroprotector
ketoconazole 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.	2.11	1	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine
khellin Khellin: A vasodilator that also has bronchodilatory action. It has been employed in the treatment of angina pectoris, in the treatment of asthma, and in conjunction with ultraviolet light A, has been tried in the treatment of vitiligo. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1024). khellin : A furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator.	2.11	1	furanochromone; organic heterotricyclic compound; oxacycle	anti-asthmatic agent; bronchodilator agent; cardiovascular drug; vasodilator agent
2-amino-3-phosphonopropionic acid 2-amino-3-phosphonopropionic acid: metabotropic glutamate receptor antagonist; do not confuse AP-3 used as an abbreviation for this with enhancer-binding protein AP-3 (a trans-activator) or clathrin assembly protein AP-3. 2-amino-3-phosphonopropanoic acid : A non-proteinogenc alpha-amino acid that is alanine in which one of the hydrogens of the terminal methyl group has been replaced by a dihydroxy(oxido)-lambda(5)-phosphanyl group.	2.11	1	alanine derivative; non-proteinogenic alpha-amino acid; phosphonic acids	human metabolite; metabotropic glutamate receptor antagonist
benzylsuccinic acid benzylsuccinic acid: inhibitor of carboxypeptidase A. 2-benzylsuccinic acid : A dicarboxylic acid consisting of succinic acid carrying a 2-benzyl substituent.	2.11	1	dicarboxylic acid	bacterial xenobiotic metabolite
beta-lapachone beta-lapachone: antineoplastic inhibitor of reverse transcriptase, DNA topoisomerase, and DNA polymerase. beta-lapachone : A benzochromenone that is 3,4-dihydro-2H-benzo[h]chromene-5,6-dione substituted by geminal methyl groups at position 2. Isolated from Tabebuia avellanedae, it exhibits antineoplastic and anti-inflammatory activities.	2.11	1	benzochromenone; orthoquinones	anti-inflammatory agent; antineoplastic agent; plant metabolite
mesoridazine Mesoridazine: A phenothiazine antipsychotic with effects similar to CHLORPROMAZINE.. mesoridazine : A phenothiazine substituted at position 2 (para to the S atom) by a methylsulfinyl group, and on the nitrogen by a 2-(1-methylpiperidin-2-yl)ethyl group.	2.11	1	phenothiazines; sulfoxide; tertiary amino compound	dopaminergic antagonist; first generation antipsychotic
methoxsalen Methoxsalen: A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.. methoxsalen : A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.	2.11	1	aromatic ether; psoralens	antineoplastic agent; cross-linking reagent; dermatologic drug; photosensitizing agent; plant metabolite
oxaprozin Oxaprozin: An oxazole-propionic acid derivative, cyclooxygenase inhibitor, and non-steroidal anti-inflammatory drug that is used in the treatment of pain and inflammation associated with of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; and ARTHRITIS, JUVENILE.. oxaprozin : A monocarboxylic acid that is a propionic acid derivative having a 4,5-diphenyl-1,3-oxazol-2-yl substituent at position 3. It is non-steroidal anti-inflammatory drug commonly used to relieve the pain and inflammatory responses associated with osteoarthritis and rheumatoid arthritis.	2.11	1	1,3-oxazoles; monocarboxylic acid	analgesic; non-steroidal anti-inflammatory drug
penicillamine [no description available]	2.11	1	non-proteinogenic alpha-amino acid; thiol
pentobarbital Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236). pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.	2.01	1	barbiturates	GABAA receptor agonist
pentoxifylline [no description available]	2.11	1	oxopurine
phenolsulfonphthalein Phenolsulfonphthalein: Red dye, pH indicator, and diagnostic aid for determination of renal function. It is used also for studies of the gastrointestinal and other systems.. phenol red : 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 4-hydroxyphenyl groups. A pH indicator changing colour from yellow below pH 6.8 to bright pink above pH 8.2, it is commonly used as an indicator in cell cultures and in home swimming pool test kits. It is also used in the (now infrequently performed) phenolsulfonphthalein (PSP) test for estimation of overall blood flow through the kidney.	2.11	1	2,1-benzoxathiole; arenesulfonate ester; phenols; sultone	acid-base indicator; diagnostic agent; two-colour indicator
Picrotin, analytical standard [no description available]	2.11	1	furopyran
pomiferin pomiferin: structure in first source	2.11	1	isoflavanones
pridinol pridinol: antispasmodic & muscle relaxant; RN given refers to parent cpd; structure in Merck Index, 9th ed, #7539. pridinol : A piperidine substituted at position 1 by a 3-hydroxy-3,3-diphenylpropyl group.	2.11	1	piperidines; tertiary alcohol	antiparkinson drug; muscle relaxant
sulfaquinoxaline Sulfaquinoxaline: An antiprotozoal agent used to combat coccidial infections of swine, cattle, fowl, and other veterinary animals. Also used in controlling outbreaks of fowl typhoid and fowl cholera and in treatment of infectious enteritis.	2.11	1	benzenes; sulfonamide
suramin Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.	2.11	1	naphthalenesulfonic acid; phenylureas; secondary carboxamide	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug
4-methylglutamic acid 4-methylglutamic acid : A glutamic acid derivative that is glutamic acid substituted by a methyl group at position 4.	2.11	1	amino dicarboxylic acid; glutamic acid derivative
temozolomide [no description available]	7.25	1	imidazotetrazine; monocarboxylic acid amide; triazene derivative	alkylating agent; antineoplastic agent; prodrug
pilocarpine hydrochloride pilocarpine hydrochloride : The hydrochloride salt of (+)-pilocarpine, a medication used to treat increased pressure inside the eye and dry mouth.	2.11	1	hydrochloride
veratramine veratramine: structure. veratramine : A piperidine alkaloid comprising the 14,15,16,17-tetradehydro derivative of veratraman having two hydroxy groups at the 3- and 23-positions.	2.11	1	piperidine alkaloid
gibberellic acid gibberellic acid: RN given refers to (1alpha,2beta,4aalpha,4bbeta,10beta)-isomer; structure. gibberellin A3 : A C19-gibberellin that is a pentacyclic diterpenoid responsible for promoting growth and elongation of cells in plants. Initially identified in Gibberella fujikuroi,it differs from gibberellin A1 in the presence of a double bond between C-3 and C-4.	2.11	1	C19-gibberellin; gibberellin monocarboxylic acid; lactone; organic heteropentacyclic compound	mouse metabolite; plant metabolite
alpha-pinene [no description available]	2.21	1	pinene	plant metabolite
santowhite powder 4,4'-butylidenebis(6-tert-butyl-m-cresol): putatively both an androgen and estrogen antagonist; structure in first source	2.11	1
fentichlor fentichlor: structure. fenticlor : An aryl sulfide having two 5-chloro-2-hydroxyphenyl groups attached to sulfur; an antiinfective drug mostly used in veterinary medicine.	2.11	1	aryl sulfide; bridged diphenyl antifungal drug; monochlorobenzenes; polyphenol	antiinfective agent; drug allergen
pyrrolidonecarboxylic acid Pyrrolidonecarboxylic Acid: A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism.. 5-oxo-L-proline : An optically active form of 5-oxoproline having L-configuration.	2.11	1	5-oxoproline; L-proline derivative; non-proteinogenic L-alpha-amino acid	algal metabolite
hexadecanolide hexadecanolide: structure in first source	2.11	1	macrolide
pamoic acid pamoic acid: RN given refers to parent cpd; structure	2.11	1	dicarboxylic acid
carzenide [no description available]	2.11	1	sulfonamide
estradiol 17 beta-cypionate [no description available]	2.11	1	steroid ester
lithocholic acid Lithocholic Acid: A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic.. lithocholic acid : A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.. lithocholate : A bile acid anion that is the conjugate base of lithocholic acid.	2.11	1	bile acid; C24-steroid; monohydroxy-5beta-cholanic acid	geroprotector; human metabolite; mouse metabolite
jervine jervine: teratogen from Veratrum grandiflorum; RN given refers to parent cpd(3beta,23beta)-isomer; structure	2.11	1	piperidines
bicuculline Bicuculline: An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.. bicuculline : A benzylisoquinoline alkaloid that is 6-methyl-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinoline which is substituted at the 5-pro-S position by a (6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl group. A light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungosa, Fumariaceae, and several Corydalis species.	2.11	1	benzylisoquinoline alkaloid; isoquinoline alkaloid; isoquinolines	agrochemical; central nervous system stimulant; GABA-gated chloride channel antagonist; GABAA receptor antagonist; neurotoxin
salicylurate salicylurate: RN given refers to parent cpd. salicyluric acid : An N-acylglycine in which the acyl group is specified as 2-hydroxybenzoyl.. salicylurate : A monocarboxylic acid anion that is the conjugate base of salicyluric acid, obtained by deprotonation of the carboxy group; major species at pH 7.3.	2.11	1	N-acylglycine; secondary carboxamide	human xenobiotic metabolite; uremic toxin
3,5-pyridinedicarboxylic acid 3,5-pyridinedicarboxylic acid: structure in first source	2.11	1	pyridinedicarboxylic acid
abietic acid abietic acid : An abietane diterpenoid that is abieta-7,13-diene substituted by a carboxy group at position 18.	3.16	1	abietane diterpenoid; monocarboxylic acid	plant metabolite
ricinine [no description available]	2.11	1	nitrile; pyridine alkaloid; pyridone
carinamide [no description available]	2.11	1
3,5-dibromotyrosine 3,5-dibromotyrosine: used to synthesize various secondary metabolites from marine sponges	2.11	1	monocarboxylic acid
malondialdehyde Malondialdehyde: The dialdehyde of malonic acid.. malonaldehyde : A dialdehyde that is propane substituted by two oxo groups at the terminal carbon atoms respectively. A biomarker of oxidative damage to lipids caused by smoking, it exists in vivo mainly in the enol form.	2.25	1	dialdehyde	biomarker
lucanthone hydrochloride Schistosomicides: Agents that act systemically to kill adult schistosomes.	1.98	1
hematoporphyrin Hematoporphyrins: Iron-free derivatives of heme with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to the pyrrole rings. Some of these PHOTOSENSITIZING AGENTS are used in the PHOTOTHERAPY of malignant NEOPLASMS.. hematoporphyrin : A dicarboxylic acid that is protoporphyrin in which the vinyl groups at positions 7 and 12 are replaced by 1-hydroxyethyl groups.	2.11	1
acetylcysteine N-acetyl-L-cysteine : An N-acetyl-L-amino acid that is the N-acetylated derivative of the natural amino acid L-cysteine.	2.13	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary
1H-indazol-3-amine 1H-indazol-3-amine: structure in first source	2.11	1	indazoles
1,1'-methylenedi-2-naphthol 1,1'-methylenedi-2-naphthol: piscicide	2.11	1
tricarballylic acid tricarballylic acid: RN given refers to parent cpd. tricarballylic acid : A tricarboxylic acid that is glutaric acid in which one of the beta-hydrogens is substituted by a carboxy group.	2.11	1	tricarboxylic acid
popop [no description available]	2.11	1	1,3-oxazoles	fluorochrome
2-tert-butylhydroquinone 2-tert-butylhydroquinone: an anticarcinogenic and chemopreventive agent. 2-tert-butylhydroquinone : A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.	2.11	1	hydroquinones	food antioxidant
7-hydroxychlorpromazine 7-hydroxychlorpromazine: RN given refers to parent cpd	2.11	1	phenothiazines
cme-carbodiimide [no description available]	2.11	1
cyclacillin Cyclacillin: A cyclohexylamido analog of PENICILLANIC ACID.	2.11	1	penicillin	antibacterial drug
strombine N-methyliminodiacetic acid: structure in first source	2.11	1
didecyldimethylammonium chloride [no description available]	2.07	1	organic molecular entity
tiletamine hydrochloride Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.	2.52	2
1-deoxynojirimycin 1-deoxy-nojirimycin: structure in first source. duvoglustat : An optically active form of 2-(hydroxymethyl)piperidine-3,4,5-triol having 2R,3R,4R,5S-configuration.	2.08	1	2-(hydroxymethyl)piperidine-3,4,5-triol; piperidine alkaloid	anti-HIV agent; anti-obesity agent; bacterial metabolite; EC 3.2.1.20 (alpha-glucosidase) inhibitor; hepatoprotective agent; hypoglycemic agent; plant metabolite
thymolphthalein Thymolphthalein: Used as a pH indicator and as a reagent for blood after decolorizing the alkaline solution by boiling with zinc dust.	2.11	1	terpene lactone
1,4,5,8-naphthalenetetracarboxylic acid 1,4,5,8-naphthalenetetracarboxylic acid: structure given in first source	2.11	1
(7S,9S)-7-[(4-amino-5-hydroxy-6-methyl-2-oxanyl)oxy]-6,9,11-trihydroxy-9-(2-hydroxy-1-oxoethyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione [no description available]	2.11	1	anthracycline
alkenes [no description available]	2.02	1
hydroxyphenylazouracil Hydroxyphenylazouracil: Inhibitor of DNA replication in gram-positive bacteria.	2.11	1
canadine canadine: RN given refers to cpd without isomeric designation; structure. canadine : A berberine alkaloid that is 5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline substituted by methoxy groups at positions 9 and 10.	2.11	1	aromatic ether; berberine alkaloid; organic heteropentacyclic compound; oxacycle
pimonidazole pimonidazole: structure given in first source	2.11	1
flavone acetic acid flavone acetic acid: structure given in first source	2.11	1
trichlorophene trichlorophene: contains 20 carbon atoms; do not confuse with trichlorophene as name for trichloro derivs of 2,2'-methylenebisphenol (contain 13 carbon atoms)	2.11	1
verapamil hydrochloride verapamil hydrochloride : A racemate comprising equimolar amounts of dexverapamil hydrochloride and (S)-verapamil hydrochloride.	2.11	1
4-aminomethylbenzoic acid [no description available]	2.11	1	benzoic acids
propazole propazole: RN given refers to parent cpd; structure	2.11	1	benzimidazoles
reserpic acid reserpic acid: inhibitor of norepinephrine transport into chromaffin vesicle ghosts; RN given refers to (3beta,16beta,17alpha,18beta,20alpha)-isomer parent cpd; structure given in first source	2.11	1	yohimban alkaloid
pifexole pifexole: structure	2.11	1
Diphenolic acid diphenolic acid: an estrogenic ligand	2.11	1	bisphenol
Melicopidine [no description available]	2.11	1	acridines
artemisinin (+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.	2	1	organic peroxide; sesquiterpene lactone	antimalarial; plant metabolite
resorufin [no description available]	2.11	1	phenoxazine
vinburnine [no description available]	2.11	1	alkaloid
pacein PAcein: structure. pacein : A member of the class of benzofurans that is dibenzo[b,d]furan-3,7-dione bearing two methyl substituents at positions 1 and 9 as well as two 2,4-dihydroxy-6-methylanilino substituents at positions 2 and 8.. orcein : A variable mixture of several compounds isolated from lichens, the eight most abundant being alpha-aminoorcein, alpha-hydroxyorcein, beta-aminoorcein, gamma-aminoorcein, beta-hydroxyorcein, gamma-hydroxyorcein, beta-aminoorceimine and beta-aminoorceimine (all are phenoxazine-based). It is used for the demonstration of elastic fibres as well as to stain the rough endoplasmic reticulum of hepatitis B infected liver cells.	2.11	1
alantolactone alantolactone: allergenic sesquiterpene lactone; crystalline mixture of alantolactones from group of sesquiterpenes; structure. alantolactone : A sesquiterpene lactone that is 3a,5,6,7,8,8a,9,9a-octahydronaphtho[2,3-b]furan-2-one bearing two methyl substituents at positions 5 and 8a as well as a methylidene substituent at position 3.	2.11	1	naphthofuran; olefinic compound; sesquiterpene lactone	antineoplastic agent; apoptosis inducer; plant metabolite
2-(4'-methylpiperazino-1-methyl)-1,3-diazafluoranthene 1-oxide 2-(4'-methylpiperazino-1-methyl)-1,3-diazafluoranthene 1-oxide: structure	2.11	1
tetrandrine tetrandrine: a bisbenzylisoquinoline that exhibits antifibrogenic activity	2.11	1	bisbenzylisoquinoline alkaloid; isoquinolines
stictic acid stictic acid: antioxidant from lichen, Usnea articulata; structure in first source	2.11	1	aromatic ether
gallocyanine gallocyanine: structure; gallocyanine-chrome alum is used as a nuclear stain to quantitate nucleic acids. gallocyanin : An organic chloride salt composed of 1-carboxy-7-(dimethylamino)-3,4-dihydroxyphenoxazin-5-ium and chloride ions in a 1:1 ratio. A histological dye used in solution with an iron alum mordant as a hematoxylin substitute in the H&E stain.	2.11	1
propylsulfonic acid propylsulfonic acid: RN given refers to cpd without locant for propyl moiety	2.11	1
1-cyclohexyl-3-(2-(4-morpholinyl)ethyl)carbodiimide N-cyclohexyl-N'-(2-(4-morpholinyl)ethyl)carbodiimide : A carbodiimide having cyclcohexyl and 2-(4-morpholinyl)ethyl as the two N-substituents.	2.11	1	carbodiimide; morpholines	cross-linking reagent
6,6'-dithiodinicotinic acid 6,6'-dithiodinicotinic acid: RN given refers to parent cpd; structure	2.11	1
va 061 VA 061: a water-soluble radical initiator; structure in first source	2.11	1
n-acetyltyrosine, (dl)-isomer N-acetyltyrosine: RN given refers to (L)-isomer. N-acetyltyrosine : An N-acetyl-amino acid that is tyrosine with an amine hydrogen substituted by an acetyl group.	2.11	1	N-acetyl-amino acid; phenols; tyrosine derivative	human urinary metabolite
cinchonine [no description available]	2.11	1	(8xi)-cinchonan-9-ol; cinchona alkaloid	metabolite
pyriproxyfen pyriproxyfen: an insect growth regulator; RN given refers to cpd without isomeric designation. pyriproxyfen : An aromatic ether that consists of propylene glycol having a 2-pyridyl group at the O-1 position and a 4-phenoxyphenyl group at the O-3 position.	2.21	1	aromatic ether; pyridines	juvenile hormone mimic
n(6)-(delta(2)-isopentenyl)adenine N(6)-dimethylallyladenine : A 6-isopentenylaminopurine in which has the isopentenyl double bond is located between the 2 and 3 positions of the isopentenyl group.	2.11	1	6-isopentenylaminopurine	cytokinin
2-Phthalimidoglutaricacid [no description available]	2.11	1	glutamic acid derivative
nsc-87877 NSC-87877: potent Shp2 (nonreceptor protein tyrosine phosphatase) inhibitor; structure in first source	2.11	1
methyl lithocholate methyl lithocholate: RN given refers to (3alpha,5beta)-isomer	2.11	1
nipecotic acid amide nipecotic acid amide: RN & N1 form 9th CI Form Index; RN given refers to cpd without isomeric designation. nipecotamide : The amide resulting from the formal condensation of nipecotic acid with ammonia.	2.11	1	piperidinecarboxamide
dimethacrine dimethacrine: minor descriptor (75-84); on-line & Index Medicus search ACRIDINES (75-84); RN given refers to parent cpd without isomeric designation	2.11	1	acridines
widdrol [no description available]	1.98	1
dehydroabietic acid dehydroabietic acid: major aquatic toxicant in effluent of pulp and paper mills. dehydroabietic acid : An abietane diterpenoid that is abieta-8,11,13-triene substituted at position 18 by a carboxy group.. dehydroabietate : A monocarboxylic acid anion that is the conjugate base of dehydroabietic acid, obtained by deprotonation of the carboxy group.	2.11	1	abietane diterpenoid; carbotricyclic compound; monocarboxylic acid	allergen; metabolite
4-deoxypyridoxine 5'-phosphate [no description available]	2.11	1
4-(phenylthio)butanoic acid 4-(phenylthio)butanoic acid: structure in first source	2.11	1
bis-a-tda bis-A-TDA: structure given in first source	2.11	1
1-amino-2-phenylethylphosphonic acid 1-amino-2-phenylethylphosphonic acid: RN given refers to cpd without isomeric designation: structure given in first source	2.11	1
4-fluoro-alpha-hydroxybenzeneacetic acid 4-fluoro-alpha-hydroxybenzeneacetic acid: an aprepitant urinary metabolite; structure in first source	2.11	1
Isopteropodin [no description available]	2.11	1	indolizines
benzpiperylone benzpiperylone: spelled benzopiperylone in title	2.11	1	pyrazoles; ring assembly
ambrox ambrox: structure in first source	3.16	1	naphthofuran
carboxyamido-triazole carboxyamido-triazole: structure given in first source; coccidiostat; U.S. patent No. 4,590,201	2.11	1
terpinyl acetate terpinyl acetate: ingredient in perfume of spray starch causing contact urticaria	2.6	1	p-menthane monoterpenoid
nsc 607097 [no description available]	2.11	1
pacifenol pacifenol: isolated from sea weeds and marine alga Laurencia claviformis; RN refers to (2R,5R,5aR,7S,8S,9aS)-isomer; structure in first source	2.11	1
n-phenyliminodiacetic acid [no description available]	2.11	1
halleridone halleridone: from Cornus Controversa, Mimulus glabratus and M. luteus; structure in first source	2.52	2
cyc 202 seliciclib : 2,6-Diaminopurine carrying benzylamino, (2R)-1-hydroxybutan-2-yl and isopropyl substituents at C-6, C-2-N and N-9 respectively. It is an experimental drug candidate in the family of pharmacological cyclin-dependent kinase (CDK) inhibitors.	2.11	1	2,6-diaminopurines	antiviral drug; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor
t-cadinol T-cadinol: extract of scented myrrh; RN given refers to (1S-(1alpha,4alpha,4aalpha,8abeta)-isomer; RN for cpd without isomeric designation not avail 3/92; structure given in first source. tau-cadinol : A cadinane sesquiterpenoid that is cadin-4-ene carrying a hydroxy substituent at position 10.	2.07	1	cadinane sesquiterpenoid; carbobicyclic compound; octahydronaphthalenes; tertiary alcohol	plant metabolite; volatile oil component
sclareol sclareol: structure given in first source. sclareol : A labdane diterpenoid that is labd-14-ene substituted by hydroxy groups at positions 8 and 13. It has been isolated from Salvia sclarea.	3.16	1	labdane diterpenoid	antifungal agent; antimicrobial agent; apoptosis inducer; fragrance; plant metabolite
cystamine hydrochloride [no description available]	2.11	1
dipiperidinoethane-di-n-oxide dipiperidinoethane-di-N-oxide: oxidized neurotoxic dipiperidinoethane deriv; structure given in first source	2.11	1
phenazopyridine lapachenole: photoaffinity label	2.52	2	benzochromene
benzyl-beta-d-xyloside benzyl-beta-D-xyloside: RN given refers to (beta-D)-isomer	2.11	1
2,2'-(3-methylcyclohexane-1,1-diyl)diacetic acid [no description available]	2.11	1	dicarboxylic acid
2,4-dinitrophenylacetic acid 2,4-dinitrophenylacetic acid: RN given refers to parent cpd	2.11	1
sitosterol, (3beta)-isomer Sobatum: tradename; active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity. sitosterol : A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.	2.11	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; C29-steroid; phytosterols; stigmastane sterol	anticholesteremic drug; antioxidant; mouse metabolite; plant metabolite; sterol methyltransferase inhibitor
(5-Phenyl-1,2,4-triazol-3-yl)urea [no description available]	2.11	1	benzenes
fumagillol fumagillol: from Penicillium jensenii; FR 65814 is an analog; structure given in first source. fumagillol : A sesquiterpenoid with antimicrobial properties.	2.11	1	secondary alcohol; sesquiterpenoid; spiro-epoxide	antimicrobial agent
vacquinol-1 [no description available]	2.11	1
aspidospermine aspidospermine: an indole fused to a qunoline; isolated from Aspidosperma tree; structure given in first source. aspidospermine : An indole alkaloid having the structure of aspirospermidine methoxylated at C-17 and acetylated at N-1.	2.11	1	indole alkaloid
guaiol guaiol: structure in first source	2.44	2	guaiane sesquiterpenoid
benzatropine methanesulfonate [no description available]	2.11	1
pseudoyohimbine [no description available]	2.11	1	methyl 17-hydroxy-20xi-yohimban-16-carboxylate
gant58 GANT58: inhibits hedgehog signalling; structure in first source	2.11	1	pyridines
benzofurans Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.	2.52	2
nsc 88915 4-pregnen-21-ol-3,20-dione-21-(4-bromobenzenesufonate): a tyrosyl-DNA phosphodiesterase inhibitor; structure in first source	2.11	1
dunnione dunnione: RN given for (+)-isomer; an industrial fungicide; structure in first source	2.52	2	naphthofuran
o-acetylsolasodine [no description available]	2.11	1
viroallosecurinine [no description available]	2.11	1	indolizines
4-methyl-2-quinazolinamine 4-methyl-2-quinazolinamine: from Streptomyces of TCM plant; structure in first source	2.11	1
1-amino-9,10-dioxo-4-(3-sulfamoylanilino)anthracene-2-sulfonic acid 1-amino-9,10-dioxo-4-(3-sulfamoylanilino)anthracene-2-sulfonic acid: inhibits PH domain leucine-rich repeat protein phosphatase; structure in first source	2.11	1
adamantoylcytarabine adamantoylcytarabine: RN given refers to parent cpd; structure in Negwer, 5th ed, #4393	2.11	1
6,11-dioxo-12-naphtho[2,3-b]indolizinecarboxylic acid ethyl ester [no description available]	2.11	1	naphthalenes
noscapine Noscapine: A naturally occurring opium alkaloid that is a centrally acting antitussive agent.. (-)-noscapine : A benzylisoquinoline alkaloid that is 1,2,3,4-tetrahydroisoquinoline which is substituted by a 4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl group at position 1, a methylenedioxy group at positions 6-7 and a methoxy group at position 8. Obtained from plants of the Papaveraceae family, it lacks significant painkilling properties and is primarily used for its antitussive (cough-suppressing) effects.	2.11	1	aromatic ether; benzylisoquinoline alkaloid; cyclic acetal; isobenzofuranone; organic heterobicyclic compound; organic heterotricyclic compound; tertiary amino compound	antineoplastic agent; antitussive; apoptosis inducer; plant metabolite
LSM-1290 [no description available]	2.11	1	benzazepine alkaloid; cyclic acetal
2-glycineamide-5-chlorophenyl-2-pyrryl ketone [no description available]	2.11	1
nsc 154020 [no description available]	2.11	1	N-glycosyl compound
4-[(1-naphthalenylamino)-oxomethyl]benzene-1,3-dicarboxylic acid [no description available]	2.11	1	2-hydroxyisophthalic acid
2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one 2,2-bis(hydroxymethyl)-1-azabicyclo(2,2,2,)octan-3-one: structure in first source	2.11	1	cyclic ketone; quinuclidines
5-(1,3-benzodioxol-5-yl)-N-(2,4-dimethylphenyl)-1,3,4-oxadiazol-2-amine [no description available]	2.11	1	benzodioxoles
croton factor f1 croton factor F1: induces ornithine decarboxylase activity; structure given in first source. 16-hydroxyphorbol 13-decanoate 12-palmitate : A phorbol ester that consists of 16-hydroxyphorbol bearing O-hexadecanoyl (palmitoyl) and O-decanoyl substituents at position 12 and 13 respectively.	2.11	1	phorbol ester; tertiary alpha-hydroxy ketone
medicarpin (-)-medicarpin : The (-)-enantiomer of medicarpin.	2.11	1	medicarpin	plant metabolite
gitoxigenin gitoxigenin: structure	2.11	1	14beta-hydroxy steroid; 16beta-hydroxy steroid; 3beta-hydroxy steroid
aromoline aromoline: from roots of Stephania cepharantha; structure given in first source	2.11	1
nsc668394 [no description available]	2.11	1
elisabethin a elisabethin A: structure in first source	2.02	1
gant 61 GANT 61: a sonic hedgehog pathway inhibitor and Gli inhibitor; structure in first source. GANT61 : An aminal that is hexahydropyrimidine which is substituted on each nitrogen by a 2-(dimethylamino)benzyl group, and at the aminal carbon by a pyridin-4-yl group. A Hedgehog signaling pathway and Gli protein inhibitor.	2.11	1	aminal; dialkylarylamine; pyridines; substituted aniline; tertiary amino compound	antineoplastic agent; apoptosis inducer; glioma-associated oncogene inhibitor; Hedgehog signaling pathway inhibitor
nortriptyline hydrochloride [no description available]	2.11	1	organic tricyclic compound	geroprotector
thujopsene thujopsene: from cell suspension culture of Caragana chamlagu; structure in first source. thujopsene : A carbotricyclic compound that is cis-1,1a,4,4a,5,6,7,8-octahydrocyclopropa[d]naphthalene which is substituted by methyl groups at the 2, 4a, 8 and 8 positions.. (-)-thujopsene : A thujopsene that has (S,S,S)-configuration.	7.53	2	thujopsene	plant metabolite
acarbose [no description available]	2.08	1	amino cyclitol; glycoside
farnesyl pyrophosphate farnesyl pyrophosphate: a sesquiterpene that dimerizes to SQUALENE; RN given refers to cpd without isomeric designation. 2-trans,6-trans-farnesyl diphosphate : The trans,trans-stereoisomer of farnesyl diphosphate.	2.46	2	farnesyl diphosphate	Escherichia coli metabolite; mouse metabolite
nsc 45641 [no description available]	2.11	1
geraniol [no description available]	2.11	1	3,7-dimethylocta-2,6-dien-1-ol; monoterpenoid; primary alcohol	allergen; fragrance; plant metabolite; volatile oil component
aconitic acid cis-aconitic acid : The cis-isomer of aconitic acid.	2.11	1	aconitic acid	fundamental metabolite
amygdalin [no description available]	2.11	1
sesquiterpenes [no description available]	3.68	9
alpha-phenylcinnamate alpha-phenylcinnamate: RN given refers to parent cpd	2.11	1
curcumin Curcumin: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.. curcumin : A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.	2.11	1	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger
caryophyllene oxide caryophyllene oxide: has butyrylcholinesterase inhibitory activity; structure in first source. epoxide : Any cyclic ether in which the oxygen atom forms part of a 3-membered ring.	7.05	1	epoxide	metabolite
ethyldimethylaminopropyl carbodiimide 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride: structure in first source	2.11	1
tamoxifen citrate [no description available]	2.11	1	citrate salt	angiogenesis inhibitor; anticoronaviral agent
1,1-diphenyl-2-picrylhydrazyl 1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)	2.05	1
eskazine [no description available]	2.11	1
nsc 336628 [no description available]	2.11	1
1,3-dimethyl-8-[2-(1-pyrrolidinyl)ethylthio]-6-sulfanylidene-7H-purin-2-one [no description available]	2.11	1	oxopurine
t-muurolol T-muurolol: antifungal from Calocedrus formosana leaf; structure in first source. (-)-Tau-muurolol : A cadinane sesquiterpenoid that consists of 4-isopropyl-1,6-dimethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalene having a hydroxy substituent at position 1 and (1S,4S,4aR,8aS)-configuration.	2.07	1	cadinane sesquiterpenoid; carbobicyclic compound; octahydronaphthalenes; tertiary alcohol	bacterial metabolite; fungicide; marine metabolite; plant metabolite; volatile oil component
cambinol cambinol: inhibitor of human silent information regulator 2 enzymes; structure in first source	2.11	1
nsc 117199 [no description available]	2.11	1
naphthoquinones Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.	2.52	2
stigmasterol stigmasta-5,22-dien-3-ol: isolated from freeze-dried powder of Blackberries (Rubus ursinus L.) which showed an activity on inhibition of chemocarcinogen. stigmasterol : A 3beta-sterol that consists of 3beta-hydroxystigmastane having double bonds at the 5,6- and 22,23-positions.	2	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; phytosterols; stigmastane sterol	plant metabolite
humulene humulene: structure given in first source. (1E,4E,8E)-alpha-humulene : The (1E,4E,8E)-isomer of alpha-humulene.	2.6	1	alpha-humulene
mangostin mangostin: xanthone from rind of Garcinia mangostana Linn. fruit. alpha-mangostin : A member of the class of xanthones that is 9H-xanthene substituted by hydroxy group at positions 1, 3 and 6, a methoxy group at position 7, an oxo group at position 9 and prenyl groups at positions 2 and 8. Isolated from the stems of Cratoxylum cochinchinense, it exhibits antioxidant, antimicrobial and antitumour activities.	2.11	1	aromatic ether; phenols; xanthones	antimicrobial agent; antineoplastic agent; antioxidant; plant metabolite
coumestrol Coumestrol: A daidzein derivative occurring naturally in forage crops which has some estrogenic activity.. coumestrol : A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.	2.11	1	coumestans; delta-lactone; polyphenol	anti-inflammatory agent; antioxidant; plant metabolite
rottlerin rottlerin: an angiogenesis inhibitor; an inhibitor of protein kinase Cdelta (PKCdelta) and calmodulin kinase III; RN refers to (E)-isomer; do not confuse this chalcone with an anthraquinone that is also called rottlerin (RN 481-72-1);. rottlerin : A chromenol that is 2,2-dimethyl-2H-chromene substituted by hydroxy groups at positions 5 and 7, a 3-acetyl-2,4,6-trihydroxy-5-methylbenzyl group at position 6 and a (1E)-3-oxo-1-phenylprop-1-en-3-yl group at position 8. A potassium channel opener, it is isolated from Mallotus philippensis.	2.11	1	aromatic ketone; benzenetriol; chromenol; enone; methyl ketone	anti-allergic agent; antihypertensive agent; antineoplastic agent; apoptosis inducer; K-ATP channel agonist; metabolite
ellagic acid [no description available]	2.11	1	catechols; cyclic ketone; lactone; organic heterotetracyclic compound; polyphenol	antioxidant; EC 1.14.18.1 (tyrosinase) inhibitor; EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor; EC 2.4.1.1 (glycogen phosphorylase) inhibitor; EC 2.5.1.18 (glutathione transferase) inhibitor; EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor; EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor; EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; food additive; fungal metabolite; geroprotector; plant metabolite; skin lightening agent
nerolidol nerolidol: sesquiterpene; RN given refers to cpd without isomeric designation; nerol is also available. nerolidol : A farnesane sesquiterpenoid that is dodeca-1,6,10-triene which carries methyl groups at positions 3, 7 and 11 and a hydroxy group at position 3. It is a natural product that is present in various flowers and plants with a floral odor. Chemically, it exists in two geometric isomers, trans and cis forms. It is widely used in cosmetics (e.g. shampoos and perfumes), in non-cosmetic products (e.g. detergents and cleansers) and also as a food flavoring agent.. (6Z)-nerolidol : A nerolidol in which the double bond at position 6 adopts a cis-configuration.	2.06	1	nerolidol
caryophyllene caryophyllene: RN given refers to cpd without isomeric designation; structure given in first source	2.6	1
7,8-dimethylalloxazine 7,8-dimethylalloxazine: structure. 7,8-dimethylisoalloxazine : A 7,8-dimethylbenzo[g]pteridine-2,4-dione that is isoalloxazine substituted by methyl groups at positions 7 and 8.. lumichrome : A compound showing blue fluorescence, formed by a photolysis of riboflavin in acid or neutral solution.	2.11	1	7,8-dimethylbenzo[g]pteridine-2,4-dione	plant metabolite
sclareolide sclareolide: has antineoplastic activity; synthesized by oxidation of sclareol; a minor constituent of Arnica angustifolia and Sideritis nutans; structure in first source	3.16	1
dihydrothobainone [no description available]	2.11	1
piperic acid piperinic acid: from Piper longum; structure in first source. (E,E)-piperic acid : A monocarboxylic acid that is (E)-penta-2,4-dienoic acid substituted by a 1,3-benzodioxol-5-yl group at position 5. It has been isolated from black pepper (Piper nigrum).	2.11	1	alpha,beta-unsaturated monocarboxylic acid; benzodioxoles	plant metabolite
germacrene d germacrene D: RN in 9th CI Form Index for unspecified stereoisomer: 37839-63-7	2.6	1
abscisic acid 2-trans-abscisic acid : An abscisic acid in which the two acyclic double bonds both have trans-geometry.	2.11	1	abscisic acids
radicinin radicinin: mold metabolite from plant pathogen Stemphylium radicinum; RN given refers to (2S-(2alpha,3beta,7E))-isomer; structure	2.11	1	aromatic ketone
5,6-dichloro-1H-imidazo[4,5-b]pyrazine-2-carboxylic acid [no description available]	2.11	1	imidazopyrazine
hispanolone hispanolone: structure in first source	2.11	1
cedrene cedrene: major constituent of cedarwood oil. cedr-8-ene : A sesquiterpene that is cedrane which has a double bond between positions 8 and 9.	7.83	3	bridged compound; carbotricyclic compound; polycyclic olefin; sesquiterpene	human urinary metabolite; volatile oil component
isocupressic acid isocupressic acid: a labdane that induces premature LABOR	3.16	1
stemodin stemodin: structure given in first source; isolated from Stemodia maritima; a major stemodane diterpene; RN given for (2alpha,5alpha,9beta,13alpha,17beta)-isomer	3.16	1
stemodinone stemodinone: RN given for (4aS-(4aalpha,6abeta,8alpha,9alpha,11aalpha,11bbeta))-isomer; structure in first source	3.16	1
veratridine Veratridine: A benzoate-cevane found in VERATRUM and Schoenocaulon. It activates SODIUM CHANNELS to stay open longer than normal.	2.11	1
saringosterol saringosterol: from a Chilean brown algae, Lessonia nigrescens; structure in first source	2	1
zimelidine hydrochloride [no description available]	2.11	1
chlortetracycline hydrochloride Alexomycin: a thiopeptide; a cyclic peptide antibiotic produced by Streptomyces arginensis isolated from the soil	2.11	1
viridicatumtoxin viridicatumtoxin: isolated from cultures of Penicillium viridicatum; RN given refers to 2'alpha,7'beta,11'abeta,12'beta-(-) isomer. viridicatumtoxin : A tetracycline-like polyketide antibiotic that is produced by several species of Penicillium and Aspergillus.	2.11	1
dacarbazine (E)-dacarbazine : A dacarbazine in which the N=N double bond adopts a trans-configuration.	2.11	1	dacarbazine
hematein hematein: structure. hematein : An organic heterotetracyclic compound that is -6a,7-dihydrobenzo[b]indeno[1,2-d]pyran-9-one carrying four hydroxy substituents at positions 3, 4, 6a and 10.	2.11	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	3.03	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.03	1
Acute Liver Injury, Drug-Induced [description not available]	2.25	1
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.25	1
Astrocytoma, Grade IV [description not available]	2.31	1
Glioblastoma A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.	7.31	1
Arthritis, Degenerative [description not available]	2.31	1
Osteoarthritis A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.	2.31	1
Adjuvant Arthritis [description not available]	3.25	4
Anasarca [description not available]	3.01	3
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	3.01	3
Carcinoma, Anaplastic [description not available]	2.41	1
Cancer of Lung [description not available]	2.61	2
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	7.41	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.61	2
Rheumatoid Arthritis [description not available]	2.76	2
Arthritis, Rheumatoid A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	2.76	2
Age-Related Osteoporosis [description not available]	2.6	1
Osteoporosis Reduction of bone mass without alteration in the composition of bone, leading to fractures. Primary osteoporosis can be of two major types: postmenopausal osteoporosis (OSTEOPOROSIS, POSTMENOPAUSAL) and age-related or senile osteoporosis.	7.6	1
Cardiometabolic Syndrome A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components not only include metabolic dysfunctions of METABOLIC SYNDROME but also HYPERTENSION, and ABDOMINAL OBESITY.	2.6	1
Obesity A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).	7.6	1
Metabolic Syndrome A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.	2.6	1
Besnoitiasis [description not available]	2.6	1
Poultry Diseases Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	2.6	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.58	2
Innate Inflammatory Response [description not available]	2.69	2
Nerve Pain [description not available]	2.25	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.69	2
Neuralgia Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.	2.25	1
Granulomas [description not available]	2.21	1
Ache [description not available]	2.21	1
Granuloma A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.	2.21	1
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	2.21	1
Anxiety Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS.	2.21	1
Carcinoma, Non-Small Cell Lung [description not available]	2.13	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.13	1
Alopecia Cicatrisata [description not available]	2.13	1
Contact Dermatitis [description not available]	2.13	1
Alopecia Absence of hair from areas where it is normally present.	7.13	1
Dermatitis, Contact A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.	2.13	1

cedrol

Description

Cross-References

Synonyms (67)

Research Excerpts

Overview

Effects

Bioavailability

Dosage Studied

Occurs in Manufacturing (1 Items)

Drug Classes (2)

Protein Targets (12)

Potency Measurements

Inhibition Measurements

Biological Processes (124)

Molecular Functions (34)

Ceullar Components (19)

Bioassays (309)

Research

Studies (57)

Market Indicators

Research Demand Index: 48.47

Study Types

cedrol

Description

Cross-References

Synonyms (67)

Research Excerpts

Overview

Effects

Bioavailability

Dosage Studied

Occurs in Manufacturing (1 Items)

Drug Classes (2)

Protein Targets (12)

Potency Measurements

Inhibition Measurements

Biological Processes (124)

Molecular Functions (34)

Ceullar Components (19)

Bioassays (309)

Research

Studies (57)

Market Indicators

Research Demand Index: 48.47

Study Types

Related Drugs (233)

Related Conditions (40)