| Condition | Indicated | Relationship Strength | Studies | Trials |
|---|
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments. | 0 | 2.41 | 2 | 0 |
Social Anxiety Disorder
[description not available] | 0 | 2.31 | 1 | 0 |
Phobia, Social
Anxiety disorder characterized by the persistent and irrational fear, anxiety, or avoidance of social or performance situations. | 0 | 2.31 | 1 | 0 |
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. | 0 | 4.77 | 11 | 0 |
Age-Related Memory Disorders
[description not available] | 0 | 2.79 | 3 | 0 |
Memory Disorders
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions. | 0 | 2.79 | 3 | 0 |
Alloxan Diabetes
[description not available] | 0 | 3.06 | 4 | 0 |
Diabetic Glomerulosclerosis
[description not available] | 0 | 2.25 | 1 | 0 |
Albuminuria
The presence of albumin in the urine, an indicator of KIDNEY DISEASES. | 0 | 2.25 | 1 | 0 |
Diabetic Nephropathies
KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE. | 0 | 2.25 | 1 | 0 |
Kidney Diseases
Pathological processes of the KIDNEY or its component tissues. | 0 | 2.25 | 1 | 0 |
Complications of Diabetes Mellitus
[description not available] | 0 | 2.31 | 1 | 0 |
Cognitive Decline
[description not available] | 0 | 2.31 | 1 | 0 |
Cognitive Dysfunction
Diminished or impaired mental and/or intellectual function. | 0 | 2.31 | 1 | 0 |
Aging
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. | 0 | 2.15 | 1 | 0 |
Cancer-Associated Pain
[description not available] | 0 | 2.17 | 1 | 0 |
Cancer Pain
Pain that may be caused by or related to cellular, tissue, and systemic changes that occur during NEOPLASM growth, tissue invasion, and METASTASIS. | 0 | 2.17 | 1 | 0 |
Musculoskeletal Pain
Discomfort stemming from muscles, LIGAMENTS, tendons, and bones. | 0 | 2.17 | 1 | 0 |
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms. | 0 | 2.78 | 3 | 0 |
Bowel Diseases, Inflammatory
[description not available] | 0 | 2.21 | 1 | 0 |
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER. | 0 | 2.21 | 1 | 0 |
Inflammatory Bowel Diseases
Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS. | 0 | 2.21 | 1 | 0 |
Hyperlipemia
[description not available] | 0 | 2.08 | 1 | 0 |
Hyperlipidemias
Conditions with excess LIPIDS in the blood. | 0 | 2.08 | 1 | 0 |
Alcohol Abuse
[description not available] | 0 | 3.64 | 3 | 0 |
Alcohol Drinking
Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking. | 0 | 2.44 | 2 | 0 |
Alcoholism
A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4) | 0 | 3.64 | 3 | 0 |
Anxiety
Feelings or emotions of dread, apprehension, and impending disaster but not disabling as with ANXIETY DISORDERS. | 0 | 4.08 | 5 | 0 |
Bradyarrhythmia
[description not available] | 0 | 3.38 | 2 | 0 |
Bradycardia
Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK. | 0 | 3.38 | 2 | 0 |
Weight Reduction
[description not available] | 0 | 2.1 | 1 | 0 |
Obesity
A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY). | 0 | 2.1 | 1 | 0 |
Weight Loss
Decrease in existing BODY WEIGHT. | 0 | 2.1 | 1 | 0 |
Drug Withdrawal Symptoms
[description not available] | 0 | 2.1 | 1 | 0 |
Substance Withdrawal Syndrome
Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug. | 0 | 2.1 | 1 | 0 |
Benign Neoplasms, Brain
[description not available] | 0 | 2.04 | 1 | 0 |
Brain Neoplasms
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain. | 0 | 2.04 | 1 | 0 |
Acute Confusional Senile Dementia
[description not available] | 0 | 2.05 | 1 | 0 |
Nerve Degeneration
Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways. | 0 | 2.05 | 1 | 0 |
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) | 0 | 2.05 | 1 | 0 |
Acute Disease
Disease having a short and relatively severe course. | 0 | 2.05 | 1 | 0 |
Diarrhea
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight. | 0 | 2.05 | 1 | 0 |
Angiogenesis, Pathologic
[description not available] | 0 | 2.05 | 1 | 0 |
Neuroblastoma
A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51) | 0 | 2.05 | 1 | 0 |
Dysembryoma
[description not available] | 0 | 2.06 | 1 | 0 |
Cancer of Testis
[description not available] | 0 | 2.06 | 1 | 0 |
Teratoma
A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642) | 0 | 2.06 | 1 | 0 |
Testicular Neoplasms
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms. | 0 | 2.06 | 1 | 0 |
Seminoma
A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed) | 0 | 2.06 | 1 | 0 |
Allodynia
[description not available] | 0 | 2.44 | 2 | 0 |
Nerve Pain
[description not available] | 0 | 2.06 | 1 | 0 |
Neuralgia
Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve. | 0 | 2.06 | 1 | 0 |
Chronic Illness
[description not available] | 0 | 2.06 | 1 | 0 |
Ache
[description not available] | 0 | 2.44 | 2 | 0 |
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). | 0 | 2.06 | 1 | 0 |
Pain
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS. | 0 | 2.44 | 2 | 0 |
Depression
Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders. | 0 | 4.05 | 5 | 0 |
Endotoxemia
A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators. | 0 | 2.06 | 1 | 0 |
Anorexia
The lack or loss of APPETITE accompanied by an aversion to food and the inability to eat. It is the defining characteristic of the disorder ANOREXIA NERVOSA. | 0 | 2.07 | 1 | 0 |
Disease Exacerbation
[description not available] | 0 | 2.01 | 1 | 0 |
Innate Inflammatory Response
[description not available] | 0 | 2.02 | 1 | 0 |
Inflammation
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. | 0 | 2.02 | 1 | 0 |
Cardiac Failure
[description not available] | 0 | 2.02 | 1 | 0 |
Heart Failure
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. | 0 | 2.02 | 1 | 0 |
Absence Status
[description not available] | 0 | 2.43 | 2 | 0 |
Status Epilepticus
A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30) | 0 | 2.43 | 2 | 0 |
Absence Seizure
[description not available] | 0 | 2.02 | 1 | 0 |
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder. | 0 | 2.02 | 1 | 0 |
Blood Pressure, High
[description not available] | 0 | 2.03 | 1 | 0 |
Diseases, Peripheral Vascular
[description not available] | 0 | 2.03 | 1 | 0 |
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. | 0 | 2.03 | 1 | 0 |
Peripheral Vascular Diseases
Pathological processes involving any one of the BLOOD VESSELS in the vasculature outside the HEART. | 0 | 2.03 | 1 | 0 |
Benign Psychomotor Epilepsy, Childhood
[description not available] | 0 | 2.03 | 1 | 0 |
Epilepsy, Temporal Lobe
A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the TEMPORAL LOBE, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic. (From Adams et al., Principles of Neurology, 6th ed, p321). | 0 | 2.03 | 1 | 0 |
Coronary Artery Stenosis
[description not available] | 0 | 2.03 | 1 | 0 |
Injury, Myocardial Reperfusion
[description not available] | 0 | 2.03 | 1 | 0 |
Atrioventricular Nodal Re-Entrant Tachycardia
[description not available] | 0 | 2.03 | 1 | 0 |
Ventricular Fibrillation
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST. | 0 | 2.03 | 1 | 0 |
Tachycardia, Ventricular
An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation). | 0 | 2.03 | 1 | 0 |
Coronary Stenosis
Narrowing or constriction of a coronary artery. | 0 | 2.03 | 1 | 0 |
Aura
[description not available] | 0 | 2.01 | 1 | 0 |
Epilepsy
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313) | 0 | 2.01 | 1 | 0 |