imipramine has been researched along with Pain in 96 studies
Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Low-dose gabapentin-imipramine significantly decreased the total pain score and daily paroxysmal pain episodes." | 9.14 | Low-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramine. ( Arai, YC; Arakawa, M; Hayashi, R; Kinoshita, A; Kobayashi, K; Kondo, M; Matsubara, S; Matsubara, T; Nishida, K; Nishihara, M; Shimo, K; Suetomi, K; Suzuki, C; Tohyama, Y; Ushida, T, 2010) |
| "A prospective double-blind randomized trial was conducted on 184 cancer patients with moderate to severe chronic pain to evaluate the analgesic efficacy and tolerability of diclofenac alone (50 mg q." | 9.08 | Double-blind evaluation of short-term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain. ( Celani, MG; De Angelis, V; Del Favero, A; Fumi, G; Lupatelli, M; Minotti, V; Monza, G; Pisati, R; Righetti, E; Rossetti, R; Tonato, M, 1998) |
| "The binding affinity (Bmax, Kd) of [3H]imipramine to platelet membranes was investigated in 43 patients with a diagnosis of idiopathic pain syndrome." | 9.06 | [3H]imipramine binding in idiopathic pain syndromes. Basal values and changes after treatment with antidepressants. ( Eberhard, G; Mellerup, ET; Nilsson, HL; Plenge, P; Sundequist, U; Von Knorring, L, 1989) |
| "Twelve patients with severe, painful diabetic neuropathy in the lower extremities were treated with imipramine and placebo in a fixed-dose, double-blind, crossover study of five plus five weeks." | 9.05 | Imipramine treatment of painful diabetic neuropathy. ( Frøland, A; Gram, LF; Kvinesdal, B; Molin, J, 1984) |
| "The possibility of introducing eye-wiping test as a model of acute pain was examined in rat, and it was compared with the well-known hot plate test." | 7.73 | Eye-wiping test: a sensitive animal model for acute trigeminal pain studies. ( Farazifard, R; Javan, M; Safarpour, F; Sheibani, V, 2005) |
| "Tritiated imipramine binding to whole platelets was measured in 16 chronic pain patients who were free from major depression, and in a control group." | 7.67 | Modifications of [3H]imipramine binding sites in platelets of chronic pain patients treated with mianserin. ( Ambrosio, F; Andreoli, F; Arduino, C; Arsie, D; Ceccherelli, F; Dodi, G; Eandi, M; Magni, G, 1987) |
| "Tritiated imipramine binding to whole platelets was measured in sixteen chronic pain patients not suffering from major depression and in a control group." | 7.67 | [3H] imipramine binding sites are decreased in platelets of chronic pain patients. ( Ambrosio, F; Andreoli, F; Arduino, C; Arsie, D; Ceccherelli, F; Eandi, M; Magni, G, 1987) |
| " Sprague-Dawley rats with adjuvant-induced arthritis were injected daily for 4 weeks with amitriptyline (10 mg/kg) or imipramine (10 mg/kg) or saline, beginning 21 days after the induction of arthritis." | 7.67 | Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis. ( Besson, JM; Butler, SH; Godefroy, F; Weil-Fugazza, J, 1985) |
| "High-affinity binding of 3H-imipramine was analyzed in platelet membranes from patients with chronic psychogenic pain." | 7.67 | Platelet 3H-imipramine binding in psychogenic pain patients. ( Bech, P; Hansen, HJ; Langemark, M; Loldrup, D; Mellerup, ET; Plenge, P, 1988) |
| "Imipramine dose was increased in steps of 25 mg/d every second week, and blood samples were taken at every dose." | 6.71 | TDM-based imipramine treatment in neuropathic pain. ( Bach, FW; Jensen, TS; Rasmussen, PV; Sindrup, SH, 2004) |
| "Imipramine did not cause significant changes in pain perception during the cold pressor test." | 6.70 | The analgesic effect of codeine as compared to imipramine in different human experimental pain models. ( Arendt-Nielsen, L; Bjørnsdottir, I; Enggaard, TP; Gram, LF; Hansen, SH; Poulsen, L; Sindrup, SH, 2001) |
| "Phasic pain was induced by intracutaneous electrical shocks with random intensities and interstimulus intervals." | 6.66 | Imipramine reduces experimental pain. ( Bromm, B; Meier, W; Scharein, E, 1986) |
| "Low-dose gabapentin-imipramine significantly decreased the total pain score and daily paroxysmal pain episodes." | 5.14 | Low-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramine. ( Arai, YC; Arakawa, M; Hayashi, R; Kinoshita, A; Kobayashi, K; Kondo, M; Matsubara, S; Matsubara, T; Nishida, K; Nishihara, M; Shimo, K; Suetomi, K; Suzuki, C; Tohyama, Y; Ushida, T, 2010) |
| "This study aimed to compare the effectiveness of mirtazapine and imipramine on not only the distressing symptoms of cancer patients such as pain, nausea, vomiting, appetite loss, and sleep disturbances but also depressive and anxiety symptoms." | 5.13 | Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine. ( Akbiyik, DI; Alkis, N; Cankurtaran, ES; Ozalp, E; Soygur, H; Turhan, L, 2008) |
| "A prospective double-blind randomized trial was conducted on 184 cancer patients with moderate to severe chronic pain to evaluate the analgesic efficacy and tolerability of diclofenac alone (50 mg q." | 5.08 | Double-blind evaluation of short-term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain. ( Celani, MG; De Angelis, V; Del Favero, A; Fumi, G; Lupatelli, M; Minotti, V; Monza, G; Pisati, R; Righetti, E; Rossetti, R; Tonato, M, 1998) |
| "The binding affinity (Bmax, Kd) of [3H]imipramine to platelet membranes was investigated in 43 patients with a diagnosis of idiopathic pain syndrome." | 5.06 | [3H]imipramine binding in idiopathic pain syndromes. Basal values and changes after treatment with antidepressants. ( Eberhard, G; Mellerup, ET; Nilsson, HL; Plenge, P; Sundequist, U; Von Knorring, L, 1989) |
| "Twelve patients with severe, painful diabetic neuropathy in the lower extremities were treated with imipramine and placebo in a fixed-dose, double-blind, crossover study of five plus five weeks." | 5.05 | Imipramine treatment of painful diabetic neuropathy. ( Frøland, A; Gram, LF; Kvinesdal, B; Molin, J, 1984) |
| "Animal experiments and uncontrolled clinical experience indicate that imipramine should relieve pain or enhance the effect of analgesics in osteoarthritis." | 5.04 | A clinical Trial of Tofranil in osteo-arthritis. ( Glick, EN, 1976) |
| "Imipramine is a tricyclic antidepressant (TCA) drug that is sometimes used to treat neuropathic pain." | 4.02 | Synergistic effect between imipramine and citicoline upon induction of analgesic and antidepressant effects in mice. ( Khakpai, F; Ramezanikhah, M; Valizadegan, F; Zarrindast, MR, 2021) |
| "Urinary excretion data were obtained from 55,296 patients with pain and were analyzed using liquid chromatography tandem mass spectrometry in a multiplex assay which included amitriptyline, nortriptyline, and imipramine." | 3.80 | Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing. ( Atayee, RS; Best, BM; Bordson, SJ; Ma, JD, 2014) |
| "The possibility of introducing eye-wiping test as a model of acute pain was examined in rat, and it was compared with the well-known hot plate test." | 3.73 | Eye-wiping test: a sensitive animal model for acute trigeminal pain studies. ( Farazifard, R; Javan, M; Safarpour, F; Sheibani, V, 2005) |
| " In the current study, we evaluated the behavioral effects of two standard drugs used clinically for neuropathic pain, the anticonvulsant gabapentin and antidepressant imipramine, in rats at different times after peripheral nerve injury." | 3.73 | The effect of antinociceptive drugs tested at different times after nerve injury in rats. ( Borsook, D; Hama, AT, 2005) |
| " The non-selective noradrenaline (NA) and serotonin (5-HT) reuptake inhibitors imipramine, amitriptyline and clomipramine displayed anti-inflammatory activity in the carrageenan model of paw inflammation." | 3.72 | Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat. ( Abdel-Salam, OM; El-Shenawy, SM; Nofal, SM, 2003) |
| "The effect of acute and chronic treatment with three antidepressant drugs on the cortical L-type calcium channel (measured as [3H]nitrendipine binding sites) and on the responsiveness to pain (assessed in the hot-plate test) was tested on the Wistar rat." | 3.68 | Role of calcium channels in effects of antidepressant drugs on responsiveness to pain. ( Antkiewicz-Michaluk, L; Michaluk, J; Romańska, I; Vetulani, J, 1991) |
| "Painful ejaculation following the administration of imipramine and clomipramine is described in four patients." | 3.68 | Painful ejaculation associated with antidepressants in four patients. ( Aizenberg, D; Hermesh, H; Karp, L; Weizman, A; Zemishlany, Z, 1991) |
| "The relationship between binding ratio of imipramine and plasma alpha 1-acid glycoprotein (AAG) was determined in normal subjects, patients with chest pain syndrome, and patients after myocardial infarction." | 3.67 | Imipramine binding to alpha-1-acid glycoprotein in normal subjects and cardiac patients. ( Freilich, DI; Giardina, EG, 1984) |
| "High-affinity binding of 3H-imipramine was analyzed in platelet membranes from patients with chronic psychogenic pain." | 3.67 | Platelet 3H-imipramine binding in psychogenic pain patients. ( Bech, P; Hansen, HJ; Langemark, M; Loldrup, D; Mellerup, ET; Plenge, P, 1988) |
| "Tritiated imipramine binding to whole platelets was measured in sixteen chronic pain patients not suffering from major depression and in a control group." | 3.67 | [3H] imipramine binding sites are decreased in platelets of chronic pain patients. ( Ambrosio, F; Andreoli, F; Arduino, C; Arsie, D; Ceccherelli, F; Eandi, M; Magni, G, 1987) |
| "Tritiated imipramine binding to whole platelets was measured in 16 chronic pain patients who were free from major depression, and in a control group." | 3.67 | Modifications of [3H]imipramine binding sites in platelets of chronic pain patients treated with mianserin. ( Ambrosio, F; Andreoli, F; Arduino, C; Arsie, D; Ceccherelli, F; Dodi, G; Eandi, M; Magni, G, 1987) |
| " Sprague-Dawley rats with adjuvant-induced arthritis were injected daily for 4 weeks with amitriptyline (10 mg/kg) or imipramine (10 mg/kg) or saline, beginning 21 days after the induction of arthritis." | 3.67 | Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis. ( Besson, JM; Butler, SH; Godefroy, F; Weil-Fugazza, J, 1985) |
| "The tail flick assay was used to evaluate pain perception in mice treated acutely with either of the two classical antidepressant drugs (AD) imipramine or amitriptyline, or the atypical antidepressant iprindole." | 3.67 | Hypoalgesia induced by antidepressants in mice: a case for opioids and serotonin. ( de Ceballos, ML; de Felipe, MC; Fuentes, JA, 1986) |
| "Gabapentin 2400 mg/day was given in case of treatment failure or if imipramine treatment was not possible." | 2.71 | Therapeutic outcome in neuropathic pain: relationship to evidence of nervous system lesion. ( Bach, FW; Jensen, TS; Rasmussen, PV; Sindrup, SH, 2004) |
| "Imipramine dose was increased in steps of 25 mg/d every second week, and blood samples were taken at every dose." | 2.71 | TDM-based imipramine treatment in neuropathic pain. ( Bach, FW; Jensen, TS; Rasmussen, PV; Sindrup, SH, 2004) |
| "Imipramine did not cause significant changes in pain perception during the cold pressor test." | 2.70 | The analgesic effect of codeine as compared to imipramine in different human experimental pain models. ( Arendt-Nielsen, L; Bjørnsdottir, I; Enggaard, TP; Gram, LF; Hansen, SH; Poulsen, L; Sindrup, SH, 2001) |
| " (2) Since in the low frequency range the drugs exhibited contrary effects upon spontaneous and evoked EEG activity, the pre-/post-stimulus relationship of the delta power was found to be the most sensitive measure for monitoring the cerebral bioavailability of the tested drugs." | 2.66 | Pre-stimulus/post-stimulus relations in EEG spectra and their modulations by an opioid and an antidepressant. ( Bromm, B; Meier, W; Scharein, E, 1989) |
| "Phasic pain was induced by intracutaneous electrical shocks with random intensities and interstimulus intervals." | 2.66 | Imipramine reduces experimental pain. ( Bromm, B; Meier, W; Scharein, E, 1986) |
| " Specifically, doxepin was more neurotoxic than amitriptyline, and both imipramine and trimipramine were more toxic than desipramine or amitriptyline." | 1.34 | Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model. ( Gerner, P; Haller, I; Keller, C; Klimaschewski, L; Lirk, P; Wang, GK, 2007) |
| "The initial hyperalgesia induced by 0." | 1.31 | Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia. ( Assié, MB; Bardin, L; Carilla-Durand, E; Colpaert, FC; Cosi, C; Koek, W; Pauwels, PJ; Tarayre, JP; Vacher, B; Wiesenfeld-Hallin, Z; Xu, XJ, 2002) |
| "When imipramine was used during development of tolerance, either on days 1 and 2 or on days 2 and 3, the morphine tolerance in the second phase of the test was reduced." | 1.31 | Effect of imipramine on tolerance to morphine antinociception in the formalin test. ( Sahebgharani, M; Shaverdian, S; Zarrindast, MR, 2000) |
| "The prognosis of treated hypochondriasis is good in a substantial proportion of patients." | 1.27 | Functional somatic symptoms and hypochondriasis. A survey of empirical studies. ( Kellner, R, 1985) |
| "Erythromelalgia is a syndrome characterized by erythema, burning pain and increased skin temperature of the affected extremities." | 1.27 | Erythromelalgia associated with acute diabetic neuropathy: an unusual condition. ( Bosch, X; Esmatjes, E; Goday, A; Gomis, R; Nubiola, A; Vendrell, J; Vilardell, E, 1988) |
| " Regardless of the reason for use, nonpsychiatric physicians were found to use relatively low dosages, rarely plan or effect dosage increases, and rarely discontinue medication." | 1.27 | Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians. ( Callies, AL; Popkin, MK, 1987) |
| " A clearcut dosage schedule for in- and out-patients using imipramine (Tofranil) or chlorimipramine (Anafranil) and haloperidol (Haldol) is established." | 1.26 | [The treatment of chronic pain with psychotropic drugs]. ( Kocher, R, 1978) |
| " A dosing strategy for the combbination of clomipramine and haloperidol is described." | 1.26 | [The treatment of chronic pain symptoms with psychotropic drugs (author's transl)]. ( Kocher, R, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 59 (61.46) | 18.7374 |
| 1990's | 14 (14.58) | 18.2507 |
| 2000's | 19 (19.79) | 29.6817 |
| 2010's | 2 (2.08) | 24.3611 |
| 2020's | 2 (2.08) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Malhotra, V | 1 |
| Vats, M | 1 |
| Nath, R | 1 |
| Mehta, S | 1 |
| Kumar, R | 1 |
| Bhalla, M | 1 |
| Sinha, JN | 1 |
| Shanker, K | 1 |
| Pathak, SR | 1 |
| Khakpai, F | 1 |
| Ramezanikhah, M | 1 |
| Valizadegan, F | 1 |
| Zarrindast, MR | 4 |
| Bordson, SJ | 1 |
| Atayee, RS | 1 |
| Ma, JD | 1 |
| Best, BM | 1 |
| Arai, YC | 1 |
| Matsubara, T | 1 |
| Shimo, K | 1 |
| Suetomi, K | 1 |
| Nishihara, M | 1 |
| Ushida, T | 1 |
| Kobayashi, K | 1 |
| Suzuki, C | 1 |
| Kinoshita, A | 1 |
| Kondo, M | 1 |
| Matsubara, S | 1 |
| Hayashi, R | 1 |
| Tohyama, Y | 1 |
| Nishida, K | 1 |
| Arakawa, M | 1 |
| Stephan, M | 1 |
| Helfritz, F | 1 |
| Pabst, R | 1 |
| von Hörsten, S | 1 |
| Colpaert, FC | 2 |
| Tarayre, JP | 2 |
| Koek, W | 2 |
| Pauwels, PJ | 1 |
| Bardin, L | 1 |
| Xu, XJ | 1 |
| Wiesenfeld-Hallin, Z | 1 |
| Cosi, C | 1 |
| Carilla-Durand, E | 1 |
| Assié, MB | 1 |
| Vacher, B | 1 |
| Medina, CA | 1 |
| Vousooghi, N | 1 |
| Sahebgharani, M | 3 |
| Abdel-Salam, OM | 1 |
| Nofal, SM | 1 |
| El-Shenawy, SM | 1 |
| PAOLI, F | 1 |
| DARCOURT, G | 1 |
| COSSA, P | 1 |
| LAINE, E | 1 |
| LINQUETTE, M | 1 |
| FOSSATI, P | 1 |
| STEINER, WG | 1 |
| HIMWICH, HE | 1 |
| BOUREL, M | 1 |
| SABOURAUD, O | 1 |
| CHARPENTIER, J | 2 |
| Rasmussen, PV | 2 |
| Jensen, TS | 2 |
| Sindrup, SH | 4 |
| Bach, FW | 2 |
| Karp, JF | 1 |
| Scott, J | 1 |
| Houck, P | 1 |
| Reynolds, CF | 1 |
| Kupfer, DJ | 1 |
| Frank, E | 1 |
| Hama, AT | 1 |
| Borsook, D | 1 |
| Farazifard, R | 1 |
| Safarpour, F | 1 |
| Sheibani, V | 1 |
| Javan, M | 1 |
| Duric, V | 1 |
| McCarson, KE | 1 |
| Aoki, M | 1 |
| Tsuji, M | 1 |
| Takeda, H | 1 |
| Harada, Y | 1 |
| Nohara, J | 1 |
| Matsumiya, T | 1 |
| Chiba, H | 1 |
| Haller, I | 1 |
| Lirk, P | 1 |
| Keller, C | 1 |
| Wang, GK | 1 |
| Gerner, P | 1 |
| Klimaschewski, L | 1 |
| Cankurtaran, ES | 1 |
| Ozalp, E | 1 |
| Soygur, H | 1 |
| Akbiyik, DI | 1 |
| Turhan, L | 1 |
| Alkis, N | 1 |
| Dalessio, DJ | 1 |
| Kvinesdal, B | 1 |
| Molin, J | 1 |
| Frøland, A | 1 |
| Gram, LF | 3 |
| Freilich, DI | 1 |
| Giardina, EG | 1 |
| Appelbaum, PS | 1 |
| Kapoor, W | 1 |
| Pöldinger, W | 1 |
| Lindsay, PG | 1 |
| Wyckoff, M | 1 |
| Poulsen, L | 2 |
| Arendt-Nielsen, L | 2 |
| Brøsen, K | 1 |
| Nielsen, KK | 1 |
| Balon, R | 1 |
| Yeragani, VK | 1 |
| Pohl, R | 1 |
| Ramesh, C | 1 |
| Pfeifer, MA | 1 |
| Ross, DR | 1 |
| Schrage, JP | 1 |
| Gelber, DA | 1 |
| Schumer, MP | 1 |
| Crain, GM | 1 |
| Markwell, SJ | 1 |
| Jung, S | 1 |
| Imananagha, KK | 1 |
| Imananagha, LN | 1 |
| Akpan, NA | 1 |
| Taniguchi, K | 1 |
| Yoshitake, S | 1 |
| Iwasaka, H | 1 |
| Honda, N | 1 |
| Oyama, T | 1 |
| Minotti, V | 1 |
| De Angelis, V | 1 |
| Righetti, E | 1 |
| Celani, MG | 1 |
| Rossetti, R | 1 |
| Lupatelli, M | 1 |
| Tonato, M | 1 |
| Pisati, R | 1 |
| Monza, G | 1 |
| Fumi, G | 1 |
| Del Favero, A | 1 |
| Perera, M | 1 |
| Khan, MA | 1 |
| Gambarana, C | 1 |
| Ghiglieri, O | 1 |
| Tolu, P | 1 |
| De Montis, MG | 1 |
| Giachetti, D | 1 |
| Bombardelli, E | 1 |
| Tagliamonte, A | 1 |
| Shaverdian, S | 1 |
| Enggaard, TP | 1 |
| Hansen, SH | 1 |
| Bjørnsdottir, I | 1 |
| Bruins Slot, LA | 1 |
| Ribet, JP | 1 |
| Kocher, R | 4 |
| Montgomery, BJ | 1 |
| Glick, EN | 1 |
| Gringras, M | 1 |
| Chrzanowski, J | 1 |
| Ansell, BM | 1 |
| Antkiewicz-Michaluk, L | 1 |
| Romańska, I | 1 |
| Michaluk, J | 1 |
| Vetulani, J | 1 |
| Aizenberg, D | 1 |
| Zemishlany, Z | 1 |
| Hermesh, H | 1 |
| Karp, L | 1 |
| Weizman, A | 1 |
| Gastmeier, K | 1 |
| Hass, M | 1 |
| Schott, H | 1 |
| Kuteifan, K | 1 |
| Tura, B | 1 |
| Tura, SM | 1 |
| Mellerup, ET | 3 |
| Dam, H | 1 |
| Kim, MY | 1 |
| Loldrup, D | 2 |
| Plenge, P | 3 |
| Rosenberg, R | 1 |
| Schepelern, S | 1 |
| Naghmi, R | 1 |
| Subuhi, R | 1 |
| Bromm, B | 2 |
| Meier, W | 2 |
| Scharein, E | 2 |
| Eberhard, G | 1 |
| Von Knorring, L | 1 |
| Nilsson, HL | 1 |
| Sundequist, U | 1 |
| Bech, P | 1 |
| Hansen, HJ | 1 |
| Langemark, M | 1 |
| Kellner, R | 1 |
| de Felipe, MC | 1 |
| de Ceballos, ML | 1 |
| Fuentes, JA | 1 |
| Magni, G | 2 |
| Andreoli, F | 2 |
| Arduino, C | 2 |
| Arsie, D | 2 |
| Ceccherelli, F | 2 |
| Ambrosio, F | 2 |
| Eandi, M | 2 |
| Vendrell, J | 1 |
| Nubiola, A | 1 |
| Goday, A | 1 |
| Bosch, X | 1 |
| Esmatjes, E | 1 |
| Gomis, R | 1 |
| Vilardell, E | 1 |
| Testa, R | 1 |
| Angelico, P | 1 |
| Abbiati, GA | 1 |
| Dodi, G | 1 |
| Beresin, EV | 1 |
| Godefroy, F | 2 |
| Butler, SH | 2 |
| Weil-Fugazza, J | 2 |
| Besson, JM | 2 |
| Cunha, UV | 1 |
| Callies, AL | 1 |
| Popkin, MK | 1 |
| Marciani, RD | 1 |
| Humphries, LL | 1 |
| Maxwell, EN | 1 |
| Costich, JF | 1 |
| Wiegert, T | 1 |
| Engelberg, J | 1 |
| Deutschmann, W | 1 |
| Hart, FD | 1 |
| Huskisson, EC | 1 |
| Liederman, PC | 1 |
| Green, R | 1 |
| Liederman, VR | 1 |
| Dyszkiewicz, W | 1 |
| Zapalski, S | 1 |
| Rybakowski, J | 1 |
| Ceraso, OL | 1 |
| Fernández Pardal, J | 1 |
| López, C | 1 |
| Fernández Pardal, MM | 1 |
| Mateos, MD | 1 |
| Honma, T | 1 |
| Sasajima, K | 1 |
| Ono, K | 1 |
| Kitagawa, S | 1 |
| Inaba, S | 1 |
| Yamamoto, H | 1 |
| Rohrer, G | 1 |
| Burov, IuV | 1 |
| Speranskaia, NP | 1 |
| Miller, SI | 1 |
| Schoenfeld, L | 1 |
| Zakusov, VV | 1 |
| Povacz, F | 1 |
| Singh, G | 1 |
| Verma, HC | 1 |
| Jaques, R | 1 |
| Helfer, H | 1 |
| Kreppel, E | 1 |
| Mönkemeier, D | 1 |
| Steffen, U | 1 |
| Nakanishi, M | 1 |
| Imamura, H | 1 |
| Maruyama, Y | 1 |
| Adjan, M | 1 |
| Kaeser, HE | 1 |
| Opitz, K | 1 |
| Borchert, U | 1 |
| Bortz, W | 1 |
| Lapalche, C | 1 |
| Thuránszky, K | 1 |
| Daxelmüller, L | 1 |
18 trials available for imipramine and Pain
| Article | Year |
|---|---|
Low-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramine.
Topics: Aged; Amines; Analgesics, Non-Narcotic; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; | 2010 |
TDM-based imipramine treatment in neuropathic pain.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Desipramine; Dose-Response Relationship, Drug; Drug Monitorin | 2004 |
Therapeutic outcome in neuropathic pain: relationship to evidence of nervous system lesion.
Topics: Acetates; Adult; Aged; Amines; Chi-Square Distribution; Cyclohexanecarboxylic Acids; Depression; Dos | 2004 |
Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine.
Topics: Adaptation, Psychological; Adjustment Disorders; Adrenergic alpha-Antagonists; Adult; Antidepressive | 2008 |
Imipramine treatment of painful diabetic neuropathy.
Topics: Adult; Aged; Clinical Trials as Topic; Diabetic Neuropathies; Double-Blind Method; Female; Humans; I | 1984 |
[Double blind comparison of the antidepressives viloxazine and imipramine (author's transl)].
Topics: Adolescent; Adult; Aged; Anxiety Disorders; Depression; Double-Blind Method; Female; Humans; Imipram | 1982 |
The hypoalgesic effect of imipramine in different human experimental pain models.
Topics: Adolescent; Adult; Analgesics; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Female | 1995 |
A highly successful and novel model for treatment of chronic painful diabetic peripheral neuropathy.
Topics: Analgesics; Capsaicin; Diabetic Neuropathies; Exercise Therapy; Female; Glycated Hemoglobin; Humans; | 1993 |
The effects of imipramine, amitriptyline and clonidine administered by iontophoresis on the pain threshold.
Topics: Adrenergic alpha-Agonists; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Clonidine; Humans | 1995 |
Double-blind evaluation of short-term analgesic efficacy of orally administered diclofenac, diclofenac plus codeine, and diclofenac plus imipramine in chronic cancer pain.
Topics: Administration, Oral; Adult; Aged; Analgesics, Opioid; Anti-Inflammatory Agents, Non-Steroidal; Anti | 1998 |
The analgesic effect of codeine as compared to imipramine in different human experimental pain models.
Topics: Adrenergic Uptake Inhibitors; Adult; Analgesics, Opioid; Codeine; Cross-Over Studies; Double-Blind M | 2001 |
Psychotropic agents finding analgesic use.
Topics: Amitriptyline; Analgesics; Chronic Disease; Clinical Trials as Topic; Drug Synergism; Fluphenazine; | 1978 |
A clinical Trial of Tofranil in osteo-arthritis.
Topics: Acetaminophen; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Humans; Imipram | 1976 |
A clinical trial of Tofranil in rheumatic pain in general practice.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Imipramine; Male; Middle Aged; Pain; Rheumati | 1976 |
Pre-stimulus/post-stimulus relations in EEG spectra and their modulations by an opioid and an antidepressant.
Topics: Adult; Delta Rhythm; Double-Blind Method; Electroencephalography; Evoked Potentials, Somatosensory; | 1989 |
[3H]imipramine binding in idiopathic pain syndromes. Basal values and changes after treatment with antidepressants.
Topics: Antidepressive Agents; Blood Platelets; Cell Membrane; Double-Blind Method; Humans; Imipramine; In V | 1989 |
Imipramine reduces experimental pain.
Topics: Adult; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Dibenzoxazepines; Double-Blind Me | 1986 |
[Treatment of severe chronic pains with a combination of thymoleptics and neuroleptics (author's transl)].
Topics: Adult; Antidepressive Agents; Atropine; Chlorpromazine; Clinical Trials as Topic; Clomipramine; Drug | 1974 |
78 other studies available for imipramine and Pain
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
Synthesis and biological evaluation of imidazoline derivatives as potential CNS and CVS agents.
Topics: Animals; Antihypertensive Agents; Central Nervous System Agents; Depression; Female; Hypertension; I | 2020 |
Synergistic effect between imipramine and citicoline upon induction of analgesic and antidepressant effects in mice.
Topics: Analgesics; Animals; Antidepressive Agents, Tricyclic; Cytidine Diphosphate Choline; Depression; Dis | 2021 |
Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing.
Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Interact | 2014 |
Postnatally induced differences in adult pain sensitivity depend on genetics, gender and specific experiences: reversal of maternal deprivation effects by additional postnatal tactile stimulation or chronic imipramine treatment.
Topics: Animals; Animals, Newborn; Antidepressive Agents, Tricyclic; Endotoxins; Female; Handling, Psycholog | 2002 |
Large-amplitude 5-HT1A receptor activation: a new mechanism of profound, central analgesia.
Topics: Acetates; Adrenergic Uptake Inhibitors; Amines; Aminopyridines; Analgesia; Analgesics; Animals; Cell | 2002 |
Clitoral priapism: a rare condition presenting as a cause of vulvar pain.
Topics: Antidepressive Agents, Tricyclic; Clitoris; Dilatation, Pathologic; Female; Genital Diseases, Female | 2002 |
Imipramine-induced antinociception in the formalin test. Receptor mechanisms involved and effect of swim stress.
Topics: Animals; Dose-Response Relationship, Drug; Imipramine; Injections, Intraventricular; Male; Mice; Mic | 2003 |
Evaluation of the anti-inflammatory and anti-nociceptive effects of different antidepressants in the rat.
Topics: Amitriptyline; Analysis of Variance; Animals; Antidepressive Agents; Carrageenan; Clomipramine; Dise | 2003 |
[Preliminary note on the action of imipramine in painful states].
Topics: Imipramine; Ozone; Pain; Psychopharmacology | 1960 |
[Action of injectable imipramine in painful syndromes].
Topics: Humans; Imipramine; Pain; Somatoform Disorders; Syndrome | 1962 |
An electroencephalographic study of the blocking action of selected tranquilizers as a function of terminal methyl amine group.
Topics: Amines; Antidepressive Agents; Chlorpromazine; Electroencephalography; Humans; Imipramine; Pain; Tra | 1963 |
[Tofranil and pain].
Topics: Humans; Imipramine; Neurology; Pain; Rheumatic Diseases | 1962 |
[EFFECTS OF IMIPRAMINE ON THE REACTION TO PAIN IN THE RAT].
Topics: Amphetamine; Amphetamines; Animals; Behavior, Animal; Imipramine; Pain; Pharmacology; Physostigmine; | 1963 |
Pain predicts longer time to remission during treatment of recurrent depression.
Topics: Antidepressive Agents, Tricyclic; Combined Modality Therapy; Comorbidity; Depressive Disorder; Femal | 2005 |
The effect of antinociceptive drugs tested at different times after nerve injury in rats.
Topics: Amines; Analgesics; Animals; Antidepressive Agents, Tricyclic; Cyclohexanecarboxylic Acids; Dose-Res | 2005 |
Eye-wiping test: a sensitive animal model for acute trigeminal pain studies.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Behavior, Animal; Cornea; Data Interpretation, S | 2005 |
Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Antidepressive | 2006 |
Antidepressants enhance the antinociceptive effects of carbamazepine in the acetic acid-induced writhing test in mice.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Antidepressive Agents; Antidepressive Agents, Second | 2006 |
Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model.
Topics: Amitriptyline; Anesthesia, Conduction; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic | 2007 |
Chronic pain syndromes and disordered cortical inhibition: effects of tricyclic compounds.
Topics: Amitriptyline; Animals; Anticonvulsants; Cerebral Cortex; Humans; Imipramine; Mice; Pain; Paresthesi | 1967 |
Imipramine binding to alpha-1-acid glycoprotein in normal subjects and cardiac patients.
Topics: Adult; Aged; Humans; Imipramine; Middle Aged; Myocardial Infarction; Orosomucoid; Pain; Protein Bind | 1984 |
Imipramine-induced vasospasm: a case report.
Topics: Adult; Depressive Disorder; Female; Foot; Hand; Humans; Imipramine; Pain; Vasoconstriction | 1983 |
The depression-pain syndrome and its response to antidepressants.
Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Depression; Desipramine; Doxepin; Fem | 1981 |
Sexual dysfunction during antidepressant treatment.
Topics: Adult; Ambulatory Care; Antidepressive Agents; Anxiety Disorders; Clomipramine; Depressive Disorder; | 1993 |
Thalamic pain syndrome of Dejerine-Roussy.
Topics: Adult; Carbamazepine; Cerebrovascular Disorders; Female; Hospitals, University; Humans; Imipramine; | 1993 |
Testicular pain and swelling on withdrawal of imipramine.
Topics: Antidepressive Agents, Tricyclic; Edema; Humans; Imipramine; Male; Middle Aged; Pain; Substance With | 1998 |
Efficacy of an Hypericum perforatum (St. John's wort) extract in preventing and reverting a condition of escape deficit in rats.
Topics: Acute Disease; Animals; Appetite; Benzazepines; Chronic Disease; Disease Models, Animal; Electroshoc | 1999 |
Effect of imipramine on tolerance to morphine antinociception in the formalin test.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Disinfectants; | 2000 |
Effect of alpha-adrenoceptor agonists and antagonists on imipramine-induced antinociception in the rat formalin test.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; | 2002 |
Experimental conditions for the continuous subcutaneous infusion of four central analgesics in rats.
Topics: Acetates; Amines; Analgesics; Anesthetics, Dissociative; Animals; Anticonvulsants; Antidepressive Ag | 2002 |
[The treatment of chronic pain symptoms with psychotropic drugs (author's transl)].
Topics: Antidepressive Agents, Tricyclic; Antipsychotic Agents; Bone Diseases; Clomipramine; Drug Therapy, C | 1976 |
[The treatment of chronic pain with psychotropic drugs].
Topics: Clomipramine; Haloperidol; Humans; Imipramine; Methotrimeprazine; Muscle Contraction; Pain; Psychotr | 1978 |
[Imipramine in the treatment of chronic sciatic pains].
Topics: Adult; Drug Evaluation; Humans; Imipramine; Middle Aged; Pain; Sciatica | 1977 |
Psyche and rheuma.
Topics: Aged; Attitude; Child; Chronic Disease; Depression; Family; Female; Humans; Imipramine; Male; Pain; | 1976 |
Role of calcium channels in effects of antidepressant drugs on responsiveness to pain.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Calcium Channels; Cerebral Cortex | 1991 |
Painful ejaculation associated with antidepressants in four patients.
Topics: Adult; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Ejaculation; Humans; Imi | 1991 |
[Pain therapy for urologic cancer patients at the Potsdam district hospital--initial results].
Topics: Aged; Amitriptyline; Analgesics; Analgesics, Opioid; Aspirin; Carbamazepine; Codeine; Dipyrone; Drug | 1990 |
The analgesic effect of tricyclic antidepressants.
Topics: Amitriptyline; Analgesia; Analgesics; Animals; Fenclonine; Imipramine; Male; Pain; Rats; Rats, Inbre | 1990 |
Imipramine binding in depressed patients with psychogenic pain.
Topics: Blood Platelets; Carrier Proteins; Depressive Disorder; Female; Humans; Imipramine; Male; Middle Age | 1990 |
Diabetic oculomotor mononeuropathy: involvement of pupillomotor fibres with slow resolution.
Topics: Blood Glucose; Diabetes Mellitus; Diabetic Neuropathies; Humans; Imipramine; Insulin; Middle Aged; O | 1990 |
Platelet 3H-imipramine binding in psychogenic pain patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anxiety Disorders; Blood Platelets; Carrier Proteins; De | 1988 |
Functional somatic symptoms and hypochondriasis. A survey of empirical studies.
Topics: Anti-Anxiety Agents; Attitude to Health; Benzodiazepines; Conditioning, Psychological; Culture; Diag | 1985 |
Hypoalgesia induced by antidepressants in mice: a case for opioids and serotonin.
Topics: Amitriptyline; Animals; Antidepressive Agents; Dibenzazepines; Drug Tolerance; Endorphins; Fenclonin | 1986 |
[3H] imipramine binding sites are decreased in platelets of chronic pain patients.
Topics: Blood Platelets; Carrier Proteins; Chronic Disease; Depressive Disorder; Female; Humans; Imipramine; | 1987 |
Erythromelalgia associated with acute diabetic neuropathy: an unusual condition.
Topics: Acute Disease; Adult; Carbamazepine; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Erythromelalg | 1988 |
Effect of citalopram, amineptine, imipramine and nortriptyline on stress-induced (footshock) analgesia in rats.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Dibenzocycloheptenes; | 1987 |
Modifications of [3H]imipramine binding sites in platelets of chronic pain patients treated with mianserin.
Topics: Binding Sites; Blood Platelets; Chronic Disease; Depressive Disorder; Female; Humans; Imipramine; Ma | 1987 |
Imipramine in the treatment of chronic pelvic pain.
Topics: Adult; Chronic Disease; Female; Humans; Imipramine; Pain; Pelvis | 1986 |
Do acute or chronic tricyclic antidepressants modify morphine antinociception in arthritic rats?
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arthritis; Arthritis, Experimental; Drug S | 1986 |
Antidepressants: their uses in nonpsychiatric disorders of aging.
Topics: Affective Symptoms; Aged; Antidepressive Agents; Chronic Disease; Colonic Diseases, Functional; Depr | 1986 |
Antidepressant treatment of medical-surgical inpatients by nonpsychiatric physicians.
Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Chronic Disease; Depressive Di | 1987 |
Chronic pain: economic, psychosocial, ethical, preventive, and medical aspects.
Topics: Adolescent; Chronic Disease; Depressive Disorder; Dexamethasone; Diagnosis, Differential; Father-Chi | 1985 |
Reduction of arthritis and pain behaviour following chronic administration of amitriptyline or imipramine in rats with adjuvant-induced arthritis.
Topics: Amitriptyline; Animals; Arthritis; Arthritis, Experimental; Behavior, Animal; Body Weight; Disease M | 1985 |
[Tofranil in pain therapy of cancer patients].
Topics: Humans; Imipramine; Neoplasms; Pain; Palliative Care | 1971 |
Pain patterns in the rheumatic disorders.
Topics: Anxiety; Arthritis; Arthritis, Rheumatoid; Aspirin; Chronic Disease; Depression; Giant Cell Arteriti | 1972 |
Outpatient group therapy with geriatric patients.
Topics: Aged; Amitriptyline; Antidepressive Agents; Anxiety; Depression; Female; Geriatrics; Humans; Imipram | 1967 |
[Usefulness of imipramine in the treatment of pain in patients with arteriosclerosis of the lower extremities].
Topics: Adult; Aged; Arteriosclerosis; Humans; Imipramine; Ischemia; Leg; Male; Middle Aged; Pain | 1974 |
[Agrypnia anesthesia with imipramine and/or desipramine].
Topics: Adult; Chemical Phenomena; Chemistry; Desipramine; Drug Evaluation; Humans; Imipramine; Male; Middle | 1974 |
Synthesis and preliminary pharmacology of a novel butyrophenone derivative, ID-4708.
Topics: Animals; Apomorphine; Avoidance Learning; Behavior, Animal; Butyrophenones; Catalepsy; Cats; Chlorpr | 1974 |
[Effect of psychotropic agents on development of an avoidance reaction in albino rats during painful electric stimulation of another rat].
Topics: Amphetamine; Animals; Antidepressive Agents; Droperidol; Electric Stimulation; Escape Reaction; Fear | 1973 |
Grief in the Navajo: psychodynamics and culture.
Topics: Adult; Crying; Culture; Depression; Female; Grief; Humans; Imipramine; Indians, North American; Male | 1973 |
[The effect tranquilizers and antidepressants on the summation of impulses of different modalities].
Topics: Animals; Auditory Perception; Central Nervous System; Chlordiazepoxide; Conditioning, Classical; Dep | 1973 |
[Therapy of severe pain due to injuries using tofranil].
Topics: Adult; Depression; Humans; Imipramine; Male; Pain; Pain, Postoperative; Phantom Limb; Wounds and Inj | 1974 |
Drug treatment of chronic intractable pain in patients referred to a psychiatry clinic.
Topics: Adolescent; Adult; Aged; Amitriptyline; Anxiety; Chlordiazepoxide; Chronic Disease; Depression; Fema | 1971 |
The antinociceptive action of a novel anxiolytic and tensiolytic drug (benzoctamine) in two different writhing syndromes.
Topics: Analgesics; Animals; Anthracenes; Arachidonic Acids; Chlordiazepoxide; Chlorpromazine; Imipramine; M | 1971 |
[Principles and risks of drug treatment of pain].
Topics: Aminopyrine; Analgesics; Antidepressive Agents; Antipyrine; Aspirin; Codeine; Dibenzazepines; Humans | 1969 |
[The management of pain with imipramine in cancer].
Topics: Dextromoramide; Female; Genital Neoplasms, Female; Humans; Imipramine; Kidney Function Tests; Liver | 1970 |
[Studies on anti-inflammatory agents. II. Analgesic and anti-edematous activities of 2-amino-3-ethoxycarbonyl-6-benzyl-4,5,6, 7-tetrahydrothieno (2,3-c)pyridine (Y-3642)].
Topics: Aminopyrine; Amphetamine; Analgesics; Animals; Anti-Inflammatory Agents; Edema; Imipramine; Male; Mi | 1970 |
[Therapeutic influence of pain symptoms in incurable tumor patients].
Topics: Humans; Imipramine; Neoplasms; Pain | 1970 |
[Therapy of polyneuritides].
Topics: Butyrophenones; Chlorpromazine; Glucocorticoids; Humans; Hypoxia; Imipramine; Methotrimeprazine; Nor | 1971 |
[On the management of pain using antidepressive agents].
Topics: Amitriptyline; Antidepressive Agents; Desipramine; Humans; Imipramine; Nortriptyline; Pain | 1967 |
[Treatment of severe pain in patients with carcinoma].
Topics: Humans; Imipramine; Neoplasms; Pain | 1967 |
[Treatment of severe pain conditions with a combination of tofranil (imipramine) and nozinan (laevopromazine)].
Topics: Adult; Aged; Female; Humans; Imipramine; Male; Middle Aged; Pain; Tranquilizing Agents | 1968 |
[Antalgic effect of certain psychotropic drugs].
Topics: Anticonvulsants; Humans; Imipramine; Neuralgia; Neuritis; Pain | 1964 |
The effect of psychopharmaca on exteroceptive blood pressure reflexes in non-anaesthetized cats.
Topics: Amphetamine; Animals; Autonomic Nervous System; Behavior, Animal; Blood Pressure; Capsicum; Cats; Ch | 1966 |
[On the therapy of severe pains with Tofranil].
Topics: Humans; Imipramine; Pain | 1966 |
[Recent studies on the action mechanism of some central nervous system analgesics. Acetylsalicylic acid, imipramine, iminostilbene].
Topics: Amphetamine; Animals; Aspirin; Atropine; Behavior, Animal; Central Nervous System; Dibenzylchloretha | 1966 |