riluzole has been researched along with Pain in 16 studies
Riluzole: A glutamate antagonist (RECEPTORS, GLUTAMATE) used as an anticonvulsant (ANTICONVULSANTS) and to prolong the survival of patients with AMYOTROPHIC LATERAL SCLEROSIS.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the efficacy, tolerability, and safety of riluzole in the treatment of peripheral neuropathic pain conditions." | 9.09 | Lack of efficacy of riluzole in the treatment of peripheral neuropathic pain conditions. ( Cluff, RS; Friedman, E; Galer, BS; Harle, J; Rowbotham, MC; Twilling, LL, 2000) |
| "Systemic (intraperitoneal) application of riluzole (8 mg/kg) inhibited audible (nocifensive response) and ultrasonic (averse affective response) vocalizations of adult rats with arthritis (5 h postinduction of a kaolin-carrageenan monoarthritis in the knee) but did not affect spinal withdrawal thresholds, which is consistent with a supraspinal action." | 7.81 | Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain. ( Ji, G; Neugebauer, V; Thompson, JM, 2015) |
| "Immediate treatment of spinal root avulsion injuries with minocycline or riluzole prevents the onset of evoked pain hypersensitivity by reducing microglial cell activation." | 7.80 | The effects of minocycline or riluzole treatment on spinal root avulsion-induced pain in adult rats. ( Carlstedt, T; Chew, DJ; Shortland, PJ, 2014) |
| "According to the results of this study, riluzole appears to have a protective effect for sepsis-induced encephalopathy." | 7.75 | The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats. ( Ercan, F; Kabasakal, L; Kaya, M; Sirvanci, S; Toklu, HZ; Uysal, MK, 2009) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 7.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "The burns produced significant hyperalgesia, but riluzole had no acute analgesic effects in normal or hyperalgesic skin." | 6.69 | Effect of riluzole on acute pain and hyperalgesia in humans. ( Hammer, NA; Kehlet, H; Lillesø, J; Pedersen, JL, 1999) |
| "To assess the efficacy, tolerability, and safety of riluzole in the treatment of peripheral neuropathic pain conditions." | 5.09 | Lack of efficacy of riluzole in the treatment of peripheral neuropathic pain conditions. ( Cluff, RS; Friedman, E; Galer, BS; Harle, J; Rowbotham, MC; Twilling, LL, 2000) |
| "Systemic (intraperitoneal) application of riluzole (8 mg/kg) inhibited audible (nocifensive response) and ultrasonic (averse affective response) vocalizations of adult rats with arthritis (5 h postinduction of a kaolin-carrageenan monoarthritis in the knee) but did not affect spinal withdrawal thresholds, which is consistent with a supraspinal action." | 3.81 | Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain. ( Ji, G; Neugebauer, V; Thompson, JM, 2015) |
| "Immediate treatment of spinal root avulsion injuries with minocycline or riluzole prevents the onset of evoked pain hypersensitivity by reducing microglial cell activation." | 3.80 | The effects of minocycline or riluzole treatment on spinal root avulsion-induced pain in adult rats. ( Carlstedt, T; Chew, DJ; Shortland, PJ, 2014) |
| "According to the results of this study, riluzole appears to have a protective effect for sepsis-induced encephalopathy." | 3.75 | The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats. ( Ercan, F; Kabasakal, L; Kaya, M; Sirvanci, S; Toklu, HZ; Uysal, MK, 2009) |
| "The effects of treatment with the anti-convulsant agents, lamotrigine and riluzole were compared with gabapentin in a rat experimental model of neuropathic pain." | 3.74 | A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain. ( Coderre, TJ; Kumar, N; Lefebvre, CD; Yu, JS, 2007) |
| "The burns produced significant hyperalgesia, but riluzole had no acute analgesic effects in normal or hyperalgesic skin." | 2.69 | Effect of riluzole on acute pain and hyperalgesia in humans. ( Hammer, NA; Kehlet, H; Lillesø, J; Pedersen, JL, 1999) |
| "Riluzole was administered intraperitoneally in adult male ddY mice." | 1.34 | Riluzole, a glutamate release inhibitor, induces loss of righting reflex, antinociception, and immobility in response to noxious stimulation in mice. ( Dohi, T; Endo, C; Irifune, M; Kawahara, M; Kikuchi, N; Morita, K; Saida, T; Sato, T; Shimizu, Y; Takarada, T, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 7 (43.75) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Rodrigues, N | 1 |
| Bennis, K | 2 |
| Vivier, D | 2 |
| Pereira, V | 1 |
| C Chatelain, F | 1 |
| Chapuy, E | 1 |
| Deokar, H | 1 |
| Busserolles, J | 1 |
| Lesage, F | 2 |
| Eschalier, A | 1 |
| Ducki, S | 2 |
| Beswick, E | 1 |
| Forbes, D | 1 |
| Hassan, Z | 1 |
| Wong, C | 1 |
| Newton, J | 1 |
| Carson, A | 1 |
| Abrahams, S | 1 |
| Chandran, S | 1 |
| Pal, S | 1 |
| Lau, FS | 1 |
| Brennan, FP | 1 |
| Gardiner, MD | 1 |
| Chew, DJ | 1 |
| Carlstedt, T | 1 |
| Shortland, PJ | 1 |
| Thompson, JM | 1 |
| Ji, G | 1 |
| Neugebauer, V | 1 |
| Scott, K | 1 |
| Shannon, R | 1 |
| Roche-Green, A | 1 |
| Searcy, R | 1 |
| Woolyhand, G | 1 |
| Meeks, G | 1 |
| Schuh, M | 1 |
| Toklu, HZ | 1 |
| Uysal, MK | 1 |
| Kabasakal, L | 1 |
| Sirvanci, S | 1 |
| Ercan, F | 1 |
| Kaya, M | 1 |
| Hayashida, K | 1 |
| Parker, RA | 1 |
| Eisenach, JC | 1 |
| Mao, J | 1 |
| Sung, B | 1 |
| Ji, RR | 1 |
| Lim, G | 1 |
| Simmons, Z | 1 |
| Coderre, TJ | 1 |
| Kumar, N | 1 |
| Lefebvre, CD | 1 |
| Yu, JS | 1 |
| Irifune, M | 1 |
| Kikuchi, N | 1 |
| Saida, T | 1 |
| Takarada, T | 1 |
| Shimizu, Y | 1 |
| Endo, C | 1 |
| Morita, K | 1 |
| Dohi, T | 1 |
| Sato, T | 1 |
| Kawahara, M | 1 |
| Hammer, NA | 1 |
| Lillesø, J | 1 |
| Pedersen, JL | 1 |
| Kehlet, H | 1 |
| Galer, BS | 1 |
| Twilling, LL | 1 |
| Harle, J | 1 |
| Cluff, RS | 1 |
| Friedman, E | 1 |
| Rowbotham, MC | 1 |
| Palazzo, E | 1 |
| de Novellis, V | 1 |
| Marabese, I | 1 |
| Cuomo, D | 1 |
| Rossi, F | 2 |
| Berrino, L | 1 |
| Maione, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Personalizing Perioperative Morphine Analgesia for Adolescents Undergoing Major Spine Surgeries[NCT01839461] | 137 participants (Actual) | Observational | 2009-07-31 | Completed | |||
| Double Blind Trial Investigating the Role of Sulfasalazine in Decreasing Opioids Requirements in Breast Cancer Patients[NCT03847311] | Phase 2 | 40 participants (Anticipated) | Interventional | 2021-05-03 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for riluzole and Pain
| Article | Year |
|---|---|
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Topics: Arrhythmias, Cardiac; Depression; Epilepsy; Humans; Inflammation; Models, Molecular; Molecular Struc | 2016 |
A systematic review of non-motor symptom evaluation in clinical trials for amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Fatigue; Humans; Pain; Riluzole; Symptom Assessment | 2022 |
Management strategies for patients with amyotrophic lateral sclerosis from diagnosis through death.
Topics: Amyotrophic Lateral Sclerosis; Hospices; Humans; Neuroprotective Agents; Nutritional Physiological P | 2005 |
2 trials available for riluzole and Pain
| Article | Year |
|---|---|
Effect of riluzole on acute pain and hyperalgesia in humans.
Topics: Acute Disease; Adult; Anesthetics; Burns; Cross-Over Studies; Double-Blind Method; Female; Humans; H | 1999 |
Lack of efficacy of riluzole in the treatment of peripheral neuropathic pain conditions.
Topics: Adult; Aged; Aged, 80 and over; Double-Blind Method; Female; Humans; Male; Middle Aged; Pain; Periph | 2000 |
11 other studies available for riluzole and Pain
| Article | Year |
|---|---|
Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel.
Topics: Analgesics; Animals; Caffeic Acids; Cinnamates; Esters; Male; Mice; Models, Molecular; Pain; Potassi | 2014 |
Multidisciplinary management of motor neurone disease.
Topics: Dyspnea; Humans; Interdisciplinary Communication; Motor Neuron Disease; Muscle Spasticity; Neuroprot | 2018 |
The effects of minocycline or riluzole treatment on spinal root avulsion-induced pain in adult rats.
Topics: Animals; Disease Models, Animal; Functional Laterality; Hyperalgesia; Male; Minocycline; Neurons; Ne | 2014 |
Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain.
Topics: Amygdala; Animals; Arthritis; Disease Models, Animal; Hindlimb; Male; Microdialysis; Pain; Rats, Spr | 2015 |
Pharmacologic Management Strategies in ALS #301.
Topics: Amyotrophic Lateral Sclerosis; Depression; Dyspnea; Guidelines as Topic; Humans; Muscle Spasticity; | 2016 |
The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats.
Topics: Animals; Blood-Brain Barrier; Body Temperature; Brain; Brain Edema; Brain Injuries; Cell Membrane Pe | 2009 |
Activation of glutamate transporters in the locus coeruleus paradoxically activates descending inhibition in rats.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Cells, Cultured; Central Nervous System Agent | 2010 |
Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity.
Topics: Amino Acid Transport System X-AG; Analgesics; Animals; Behavior, Animal; Down-Regulation; Drug Admin | 2002 |
Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity.
Topics: Amino Acid Transport System X-AG; Analgesics; Animals; Behavior, Animal; Down-Regulation; Drug Admin | 2002 |
Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity.
Topics: Amino Acid Transport System X-AG; Analgesics; Animals; Behavior, Animal; Down-Regulation; Drug Admin | 2002 |
Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity.
Topics: Amino Acid Transport System X-AG; Analgesics; Animals; Behavior, Animal; Down-Regulation; Drug Admin | 2002 |
A comparison of the glutamate release inhibition and anti-allodynic effects of gabapentin, lamotrigine, and riluzole in a model of neuropathic pain.
Topics: Amines; Analgesics; Animals; Anticonvulsants; Cold Temperature; Cyclohexanecarboxylic Acids; Disease | 2007 |
Riluzole, a glutamate release inhibitor, induces loss of righting reflex, antinociception, and immobility in response to noxious stimulation in mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Glutamic Acid; Immobilization; Male; Mice; Mo | 2007 |
Interaction between vanilloid and glutamate receptors in the central modulation of nociception.
Topics: 2-Amino-5-phosphonovalerate; Animals; Capsaicin; Chromones; Excitatory Amino Acid Antagonists; Male; | 2002 |