14-thioglycolamido-7,8-dihydromorphinone profile

14-thioglycolamido-7,8-dihydromorphinone is a synthetic opioid compound. It is not a naturally occurring substance and is not widely known or used.

It's difficult to determine the importance of this specific compound for research without more context.

**However, here's why opioid compounds in general are significant for research:**

* **Understanding opioid mechanisms:** Studying various opioid compounds helps researchers understand how they interact with opioid receptors in the brain and body, ultimately leading to pain relief, but also potential for addiction and other side effects.
* **Developing new pain medications:** Researchers are continually looking for safer and more effective pain medications. New opioid compounds are explored for their potential to provide better pain relief with fewer side effects.
* **Addiction research:** Opioid compounds are crucial for understanding the mechanisms of addiction, including tolerance, dependence, and withdrawal. This knowledge is essential for developing treatment strategies for opioid addiction.
* **Understanding other physiological effects:** Opioids can affect various bodily functions, including breathing, digestion, and mood. Studying these effects helps researchers understand the complex interactions of opioids with the body.

**Important Note:** Opioids are powerful drugs that can be highly addictive. It is crucial to only use them under the guidance of a qualified medical professional.

If you are interested in learning more about specific opioid compounds or their research applications, I recommend contacting a medical or research professional who specializes in the field. They can provide you with accurate and up-to-date information.

ID Source	ID
PubMed CID	5491871
MeSH ID	M0204615

Synonym
14-beta-(thioglycolamido)-7,8-dihydromorphinone
139292-26-5
acetamide, n-((5alpha)-4,5-epoxy-3-hydroxy-17-methyl-6-oxomorphinan-14-yl)-2-mercapto-
14-thioglycolamido-7,8-dihydromorphinone
n-(3-hydroxy-17-methyl-6-oxo-4,5-epoxymorphinan-14-yl)-2-sulfanylethanimidic acid
DTXSID70930426
n-[(4r,4as,7ar)-9-hydroxy-3-methyl-7-oxo-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinolin-4a-yl]-2-sulfanylacetamide

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	3 (60.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (40.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
fentanyl Fentanyl: A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1078). fentanyl : A monocarboxylic acid amide resulting from the formal condensation of the aryl amino group of N-phenyl-1-(2-phenylethyl)piperidin-4-amine with propanoic acid.	1.99	1	anilide; monocarboxylic acid amide; piperidines	adjuvant; anaesthesia adjuvant; anaesthetic; intravenous anaesthetic; mu-opioid receptor agonist; opioid analgesic
dithiothreitol 1,4-dimercaptobutane-2,3-diol : A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group.. 1,4-dithiothreitol : The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.	1.98	1	1,4-dimercaptobutane-2,3-diol; butanediols; dithiol; glycol; thiol	chelator; human metabolite; reducing agent
enkephalin, d-penicillamine (2,5)- Enkephalin, D-Penicillamine (2,5)-: A disulfide opioid pentapeptide that selectively binds to the DELTA OPIOID RECEPTOR. It possesses antinociceptive activity.. DPDPE : A heterodetic cyclic peptide that is a cyclic enkephalin analogue, having D-penicillaminyl residues located at positions 2 and 5, which form the heterocycle via a disulfide bond.	1.98	1	heterodetic cyclic peptide	delta-opioid receptor agonist
u 69593 U 69593: selective ligand for opioid K-receptor. U69593 : A monocarboxylic acid amide obtained by formal condensation between the carboxy group of phenylacetic acid and the secodary amino group of (5R,7S,8S)-N-methyl-7-(pyrrolidin-1-yl)-1-oxaspiro[4.5]decan-8-amine.	2.39	2	monocarboxylic acid amide; N-alkylpyrrolidine; organic heterobicyclic compound; oxaspiro compound	anti-inflammatory agent; diuretic; kappa-opioid receptor agonist
quadazocine quadazocine: RN given refers to (2 alpha,6 alpha,11S*)-(+-)-isomer	1.99	1
tosylphenylalanyl chloromethyl ketone Tosylphenylalanyl Chloromethyl Ketone: An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.. N-tosyl-L-phenylalanyl chloromethyl ketone : The N-tosyl derivative of L-phenylalanyl chloromethyl ketone.	1.98	1	alpha-chloroketone; sulfonamide	alkylating agent; serine proteinase inhibitor
enkephalin, leucine Enkephalin, Leucine: One of the endogenous pentapeptides with morphine-like activity. It differs from MET-ENKEPHALIN in the LEUCINE at position 5. Its first four amino acid sequence is identical to the tetrapeptide sequence at the N-terminal of BETA-ENDORPHIN.. Leu-enkephalin : A pentapeptide comprising L-tyrosine, glycine, glycine, L-phenylalanine and L-leucine residues joined in sequence by peptide linkages. It is an endogenous opioid peptide produced in vertebrate species, including rodents, primates and humans that results from decomposition of proenkephalin or dynorphin and exhibits antinociceptive properties.	2.38	2	pentapeptide; peptide zwitterion	analgesic; delta-opioid receptor agonist; human metabolite; mu-opioid receptor agonist; neurotransmitter; rat metabolite
hydromorphone Hydromorphone: An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.. hydromorphone : A morphinane alkaloid that is a hydrogenated ketone derivative of morphine. A semi-synthetic drug, it is a centrally acting pain medication of the opioid class.	3.1	5	morphinane alkaloid; organic heteropentacyclic compound	mu-opioid receptor agonist; opioid analgesic
morphine Meconium: The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.	1.99	1	morphinane alkaloid; organic heteropentacyclic compound; tertiary amino compound	anaesthetic; drug allergen; environmental contaminant; geroprotector; mu-opioid receptor agonist; opioid analgesic; plant metabolite; vasodilator agent; xenobiotic
morphinone [no description available]	1.98	1	morphinane alkaloid
enkephalin, ala(2)-mephe(4)-gly(5)- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-: An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.	2.38	2
enkephalin-leu, ala(2)-cys(6)- enkephalin-Leu, Ala(2)-Cys(6)-: affinity label for delta-opiate receptors	1.98	1
enkephalin, leucine-2-alanine Enkephalin, Leucine-2-Alanine: A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.	1.98	1

Condition	Relationship Strength	Studies
Ache [description not available]	1.99	1
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	1.99	1
Addiction, Opioid [description not available]	1.98	1
Opioid-Related Disorders Disorders related to or resulting from abuse or misuse of OPIOIDS.	1.98	1

14-thioglycolamido-7,8-dihydromorphinone

Cross-References

Synonyms (7)

Research

Studies (5)

Market Indicators

Research Demand Index: 12.50

Study Types