Page last updated: 2024-08-18

acrolein and Pain

acrolein has been researched along with Pain in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.45)18.7374
1990's0 (0.00)18.2507
2000's10 (34.48)29.6817
2010's15 (51.72)24.3611
2020's3 (10.34)2.80

Authors

AuthorsStudies
Basbaum, AI; Bautista, DM; Jordt, SE; Julius, D; Nikai, T; Poblete, J; Read, AJ; Tsuruda, PR; Yamoah, EN1
Cravatt, BF; Dubin, AE; Evans, MJ; Macpherson, LJ; Marr, F; Patapoutian, A; Schultz, PG1
Baraldi, PG; Geppetti, P; Materazzi, S; Preti, D1
Malekzadeh Shafaroudi, A; Molania, T; Moosazadeh, M; Rostamkalaei, SS; Saeedi, M; Salehabadi, N; Salehi, M; Valipour, F1
Fan, Z; Qi, C; Quan, X; Wang, X; Wu, S; Wu, T; Yu, C; Zhang, H1
Chen, Z; Herr, SA; Jiao, Y; Lin, Y; Rogers, E; Shi, L; Shi, R; Tang, J1
Baggio, CH; Cipriani, TR; da Silva, CF; de Souza, LM; Hamm, LA; Nascimento, AM; Nomura, EC; Rodrigues, MR; Werner, MF1
Chapman, H; Jalava, N; Koivisto, A; Korjamo, T; Lindstedt, K; Pertovaara, A; Saarnilehto, M1
Chen, P; Li, Y; Tang, C; Wang, Y; Zhang, H1
Athayde, ML; Boligon, AA; Ferreira, J; Hoffmeister, C; Klafke, JZ; Pinheiro, FV; Pinheiro, KV; Rosa, F; Rossato, MF; Tonello, R; Trevisan, G1
Imam, MZ; Khatun, A; Rana, MS1
DeBerry, JJ; Dewberry, LS; Sorge, RE; Taylor, JC; Totsch, SK; Watts, SA; Yessick, LR1
Babes, A; Barbu, I; Ciobanu, C; Kerek, F; Neacsu, C; Szegli, G; Toader, O1
Bi, H; Ji, W; Liang, J1
Abzianidze, E; Carstens, E; Carstens, MI; Gurtskaia, G; Klein, AH; Sawyer, CM; Tsagareli, MG; Tsiklauri, N; Zanotto, KL1
Córdova, MM; Pizzolatti, MG; Ruani, AP; Santos, AR; Silva, MD; Werner, MF1
Bang, S; Cho, H; Hwang, SW; Yang, TJ; Yoo, S1
Anand, P; Roberts, K; Shenoy, R1
Alenmyr, L; Greiff, L; Herrmann, A; Högestätt, ED; Zygmunt, PM1
Averbeck, B; Carr, RW; Laubender, RP; Rucker, F1
Boucher, M; Coudoré-Civiale, MA; Eschalier, A; Méen, M; Parry, L1
Bandell, M; Earley, TJ; Eid, SR; Hwang, SW; Patapoutian, A; Petrus, MJ; Story, GM; Viswanath, V1
Avelino, A; Bevan, S; Charrua, A; Cruz, F; Dinis, P; Nagy, I; Yaqoob, M1
Handwerker, HO; Maihöfner, C; Namer, B; Seifert, F1
Caterina, MJ1
Dai, Y; Fukuoka, T; Higashi, T; Kobayashi, K; Noguchi, K; Obata, K; Tominaga, M; Wang, S; Yamamoto, S; Yamanaka, H1
Andrè, E; Basbaum, AI; Bautista, DM; Bunnett, NW; Campi, B; Cottrell, GS; Gatti, R; Geppetti, P; Imamachi, N; Julius, D; Materazzi, S; Nassini, R; Patacchini, R; Siemens, J; Trevisani, M1
Handwerker, H; Jorum, E; Kleggetveit, IP; Namer, B; Schmelz, M1
Parker, CM; Smith, GG; Sprince, H1

Reviews

2 review(s) available for acrolein and Pain

ArticleYear
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
    Journal of medicinal chemistry, 2010, Jul-22, Volume: 53, Issue:14

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Asthma; Humans; Ion Channel Gating; Neurons; Pain; Peripheral Nervous System Diseases; Pulmonary Disease, Chronic Obstructive; Transient Receptor Potential Channels

2010
TRPA1: a transducer and amplifier of pain and inflammation.
    Basic & clinical pharmacology & toxicology, 2014, Volume: 114, Issue:1

    Topics: Acetanilides; Acrolein; Aldehydes; Animals; Ankyrins; Humans; Inflammation; Mustard Plant; Oximes; Pain; Plant Oils; Purines; Spinal Cord; Transient Receptor Potential Channels

2014

Trials

4 trial(s) available for acrolein and Pain

ArticleYear
Evaluation of cinnamaldehyde mucoadhesive patches on minor recurrent aphthous stomatitis: a randomized, double-blind, placebo-controlled clinical trial.
    BMC oral health, 2022, 06-14, Volume: 22, Issue:1

    Topics: Acrolein; Double-Blind Method; Humans; Pain; Retrospective Studies; Stomatitis, Aphthous; Treatment Outcome

2022
TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo.
    Clinical physiology and functional imaging, 2011, Volume: 31, Issue:6

    Topics: Acrolein; Administration, Intranasal; Adult; Aged; Arachidonic Acids; Biopsy; Calcium; Calcium Channels; Capsaicin; Cilia; Cross-Over Studies; Double-Blind Method; Endocannabinoids; Humans; Immunohistochemistry; Methanol; Middle Aged; Movement; Mucin 5AC; Mucin-5B; Mustard Plant; Nasal Lavage; Nasal Mucosa; Nerve Tissue Proteins; Pain; Pain Measurement; Plant Oils; Polyunsaturated Alkamides; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sensory System Agents; Sweden; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels; TRPV Cation Channels; Young Adult

2011
TRPA1 and TRPM8 activation in humans: effects of cinnamaldehyde and menthol.
    Neuroreport, 2005, Jun-21, Volume: 16, Issue:9

    Topics: Acrolein; Adult; Axons; Cross-Over Studies; Double-Blind Method; Female; Humans; Hyperalgesia; Ion Channels; Laser-Doppler Flowmetry; Male; Menthol; Neoplasm Proteins; Pain; Pain Measurement; Pain Threshold; Reflex; Time Factors; TRPM Cation Channels; Vasodilation

2005
Role of TRPM8 and TRPA1 for cold allodynia in patients with cold injury.
    Pain, 2008, Sep-30, Volume: 139, Issue:1

    Topics: Acrolein; Adult; Afferent Pathways; Calcium Channels; Cold Temperature; Cross-Over Studies; Double-Blind Method; Humans; Menthol; Nerve Fibers, Unmyelinated; Nerve Tissue Proteins; Nociceptors; Pain; Pain Threshold; Thermosensing; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPM Cation Channels

2008

Other Studies

23 other study(ies) available for acrolein and Pain

ArticleYear
TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents.
    Cell, 2006, Mar-24, Volume: 124, Issue:6

    Topics: Acrolein; Animals; Cold Temperature; Evoked Potentials, Auditory, Brain Stem; Garlic; Inflammation; Inhalation Exposure; Mice; Mice, Knockout; Molecular Structure; Nociceptors; Pain; Thermoreceptors; Transient Receptor Potential Channels; TRPA1 Cation Channel

2006
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines.
    Nature, 2007, Feb-01, Volume: 445, Issue:7127

    Topics: Acrolein; Animals; Cysteine; Disulfides; Dithiothreitol; Electric Conductivity; Ethyl Methanesulfonate; Humans; Ion Channel Gating; Mice; Mustard Plant; Noxae; Pain; Plant Oils; Transient Receptor Potential Channels

2007
Hydralazine plays an immunomodulation role of pro-regeneration in a mouse model of spinal cord injury.
    Experimental neurology, 2023, Volume: 363

    Topics: Acrolein; Animals; Hydralazine; Macrophages; Male; Mice; Pain; Rats; Spinal Cord; Spinal Cord Injuries

2023
Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson's disease: implication of acrolein and TRPA1.
    Translational neurodegeneration, 2021, 04-28, Volume: 10, Issue:1

    Topics: Acrolein; Animals; Behavior, Animal; Cerebral Cortex; Dimercaprol; Dopaminergic Neurons; Hydroxydopamines; Male; Motor Activity; Neostriatum; Neuroprotective Agents; Pain; Pain Measurement; Parkinson Disease, Secondary; Rats; Rats, Sprague-Dawley; Substantia Nigra; TRPA1 Cation Channel

2021
Antinociceptive effects of ethanolic extract from the flowers of Acmella oleracea (L.) R.K. Jansen in mice.
    Journal of ethnopharmacology, 2013, Nov-25, Volume: 150, Issue:2

    Topics: Acrolein; Analgesics; Animals; Asteraceae; Capsaicin; Ethanol; Flowers; Formaldehyde; Hot Temperature; Hyperalgesia; Ligation; Male; Mice; Pain; Phytotherapy; Plant Extracts; Sciatic Nerve; Solvents; Touch

2013
Antinociceptive and anti-inflammatory activities of extract and two isolated flavonoids of Carthamus tinctorius L.
    Journal of ethnopharmacology, 2014, Feb-03, Volume: 151, Issue:2

    Topics: Acetic Acid; Acrolein; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Carthamus tinctorius; Ear; Edema; Female; Foot; Glucosides; Kaempferols; Male; Mice; Pain; Phytotherapy; Plant Extracts; Xylenes

2014
Gallic acid functions as a TRPA1 antagonist with relevant antinociceptive and antiedematogenic effects in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2014, Volume: 387, Issue:7

    Topics: Acrolein; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Edema; Gallic Acid; Hydrogen Peroxide; Hyperalgesia; Male; Mice; Pain; Psychomotor Performance; Sciatic Nerve; Spinal Cord; Transient Receptor Potential Channels; TRPA1 Cation Channel

2014
Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper in mice.
    BMC complementary and alternative medicine, 2015, Mar-13, Volume: 15

    Topics: Acetic Acid; Acrolein; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Bangladesh; Behavior, Animal; Formaldehyde; Glutamic Acid; Male; Medicine, Traditional; Mice; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Phytotherapy; Plant Extracts; Plant Leaves; Polygonum

2015
A novel zebrafish-based model of nociception.
    Physiology & behavior, 2017, 05-15, Volume: 174

    Topics: Acetic Acid; Acrolein; Analgesics, Opioid; Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Histamine; Histamine Agonists; Male; Morphine; Mustard Plant; Naloxone; Narcotic Antagonists; Nociception; Pain; Plant Oils; Swimming; Zebrafish

2017
Substance MCS-18 isolated from Helleborus purpurascens is a potent antagonist of the capsaicin receptor, TRPV1, in rat cultured sensory neurons.
    Physiological research, 2010, Volume: 59, Issue:2

    Topics: Acids; Acrolein; Animals; Biological Products; Calcium; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Ganglia, Spinal; Helleborus; Hot Temperature; Membrane Potentials; Pain; Patch-Clamp Techniques; Rats; Sensory Receptor Cells; TRPV Cation Channels

2010
Involvement of TRPA1 in ET-1-induced pain-like behavior in mice.
    Neuroreport, 2010, Feb-17, Volume: 21, Issue:3

    Topics: Acrolein; Animals; Behavior, Animal; Endothelin-1; Enzyme Inhibitors; Irritants; Male; Mice; Mice, Inbred C57BL; Pain; Transient Receptor Potential Channels; TRPA1 Cation Channel

2010
Behavioral evidence of thermal hyperalgesia and mechanical allodynia induced by intradermal cinnamaldehyde in rats.
    Neuroscience letters, 2010, Apr-12, Volume: 473, Issue:3

    Topics: Acrolein; Animals; Ankyrins; Behavior, Animal; Calcium Channel Agonists; Calcium Channels; Cold Temperature; Hot Temperature; Hyperalgesia; Injections, Intradermal; Male; Pain; Rats; Rats, Sprague-Dawley; Touch; TRPA1 Cation Channel; TRPC Cation Channels

2010
Further antinociceptive effects of myricitrin in chemical models of overt nociception in mice.
    Neuroscience letters, 2011, May-20, Volume: 495, Issue:3

    Topics: Acrolein; Amiloride; Analgesics, Non-Narcotic; Animals; Bradykinin; Camphor; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Flavonoids; Functional Laterality; Hyperalgesia; Male; Mice; Models, Chemical; Pain; Pain Measurement; Pain Threshold; Ruthenium Red

2011
Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels.
    Pain, 2011, Volume: 152, Issue:5

    Topics: Acrolein; Analgesics; Animals; Calcium; Calcium Channels; Cells, Cultured; Disease Models, Animal; Freund's Adjuvant; Ganglia, Spinal; Gene Expression Regulation; Hemiterpenes; Humans; Inflammation; Membrane Potentials; Mice; Mice, Inbred ICR; Mice, Knockout; Nerve Tissue Proteins; Organophosphorus Compounds; Pain; Patch-Clamp Techniques; RNA, Messenger; RNA, Small Interfering; Sensory Receptor Cells; Transfection; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPV Cation Channels

2011
A novel human volunteer pain model using contact heat evoked potentials (CHEP) following topical skin application of transient receptor potential agonists capsaicin, menthol and cinnamaldehyde.
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2011, Volume: 18, Issue:7

    Topics: Acrolein; Adult; Capsaicin; Electroencephalography; Evoked Potentials; Female; Hot Temperature; Human Experimentation; Humans; Male; Menthol; Middle Aged; Models, Biological; Pain; Pain Measurement; Pain Threshold; Sensory System Agents; Skin; Transient Receptor Potential Channels; Young Adult

2011
Thermal grill-evoked sensations of heat correlate with cold pain threshold and are enhanced by menthol and cinnamaldehyde.
    European journal of pain (London, England), 2013, Volume: 17, Issue:5

    Topics: Acrolein; Adult; Cold Temperature; Female; Hot Temperature; Humans; Male; Menthol; Nociceptors; Pain; Pain Measurement; Pain Threshold; Skin; Thermosensing

2013
Involvement of N-methyl-D-aspartate receptors in nociception in the cyclophosphamide-induced vesical pain model in the conscious rat.
    European journal of pain (London, England), 2002, Volume: 6, Issue:4

    Topics: Acrolein; Animals; Antineoplastic Agents, Alkylating; Behavior, Animal; Cyclophosphamide; Cystitis; Dizocilpine Maleate; Dose-Response Relationship, Drug; Injections, Intravenous; Injections, Spinal; Ketamine; Male; Models, Animal; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

2002
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.
    Neuron, 2004, Mar-25, Volume: 41, Issue:6

    Topics: Acrolein; Animals; Behavior, Animal; Bradykinin; Cell Membrane; CHO Cells; Cold Temperature; Cricetinae; Dose-Response Relationship, Drug; Humans; Inflammation Mediators; Ion Channels; Membrane Potentials; Mice; Neurons, Afferent; Nociceptors; Pain; Pain Measurement; Rats; Transient Receptor Potential Channels; TRPA1 Cation Channel; Type C Phospholipases

2004
Anandamide-evoked activation of vanilloid receptor 1 contributes to the development of bladder hyperreflexia and nociceptive transmission to spinal dorsal horn neurons in cystitis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Dec-15, Volume: 24, Issue:50

    Topics: Acrolein; Animals; Arachidonic Acids; Capsaicin; Cyclophosphamide; Cystitis; Endocannabinoids; Female; Hydrolysis; Ion Channels; Pain; Polyunsaturated Alkamides; Posterior Horn Cells; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reflex, Abnormal; TRPV Cation Channels; Urinary Bladder

2004
Chemical biology: sticky spices.
    Nature, 2007, Feb-01, Volume: 445, Issue:7127

    Topics: Acrolein; Animals; Cysteine; Humans; Ion Channel Gating; Mice; Mustard Plant; Pain; Plant Oils; Spices; Taste; Transient Receptor Potential Channels

2007
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:7

    Topics: Acrolein; Animals; Ankyrins; Behavior, Animal; Calcium Channels; Cell Line; Electrophysiology; Enzyme Activation; Ganglia, Spinal; Gene Expression Regulation; Humans; Inflammation; Isothiocyanates; Male; Nerve Tissue Proteins; Pain; Patch-Clamp Techniques; Phosphatidylinositol 4,5-Diphosphate; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Transient Receptor Potential Channels; TRPA1 Cation Channel; TRPC Cation Channels; Type C Phospholipases

2007
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Aug-14, Volume: 104, Issue:33

    Topics: Acrolein; Aldehydes; Ankyrins; Calcium Channels; Cell Line; Cloning, Molecular; Humans; Inflammation; Pain; Patch-Clamp Techniques; TRPA1 Cation Channel; TRPC Cation Channels

2007
Comparison of protection by L-ascorbic acid, L-cysteine, and adrenergic-blocking agents against acetaldehyde, acrolein, and formaldehyde toxicity: implications in smoking.
    Agents and actions, 1979, Volume: 9, Issue:4

    Topics: Acetaldehyde; Acrolein; Adrenergic beta-Antagonists; Aldehydes; Anesthesia; Animals; Ascorbic Acid; Cysteine; Formaldehyde; Humans; Infant, Newborn; Male; Pain; Rats; Respiratory Distress Syndrome, Newborn; Smoking; Time Factors

1979