prolyl-glycyl-proline profile

ID Source	ID
PubMed CID	145457474
CHEBI ID	162325
MeSH ID	M0292366

Synonym
(2r)-1-[2-[[(2s)-pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylic acid
pro-gly-pro
CHEBI:162325
prolyl-glycyl-proline
l-prolyl-glycyl-l-proline

Class	Description
peptide	Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc.

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	4 (4.71)	18.2507
2000's	26 (30.59)	29.6817
2010's	50 (58.82)	24.3611
2020's	5 (5.88)	2.80

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	6 (6.25%)	6.00%
Case Studies	1 (1.04%)	4.05%
Observational	0 (0.00%)	0.25%
Other	89 (92.71%)	84.16%

Substance	Classes	Roles	Relationship Strength
enkephalin, leucine	peptide		low
2-[[2-formamido-4-(methylthio)-1-oxobutyl]amino]propanoic acid	peptide		low
n-formylmethionylphenylalanine	peptide		low
substance p	peptide	neurokinin-1 receptor agonist; neurotransmitter; vasodilator agent	low
enalkiren	peptide		low
kynostatin 272	peptide		low
terlakiren	peptide		low
kni 102	peptide		low
pidotimod	peptide		low
cefpimizole	peptide		low
aspoxicillin	peptide		low
pro-diazepam	peptide		low
moexipril	peptide		low
mci 9038	peptide		low
leucylleucine	peptide		low
diprotin a	peptide		low
fk 888	peptide		low
calpain inhibitor 2	peptide		low
formylmethionyl-leucyl-phenylalanine methyl ester	peptide		low
t-kinin	peptide		low
3-(n-maleimidopropionyl)biocytin	peptide		low
cefbuperazone	cephalosporin; peptide		low
endothelin (16-21)	peptide		low
n-valyltryptophan	peptide		low
neurotensin (1-8)	peptide zwitterion; peptide	human metabolite	low
alanylaspartic acid	peptide		low
fibrin	peptide		low
n-carbobenzoxyglycylproline	peptide		low
s-(4-azidophenacyl)glutathione	peptide		low
bq 485	peptide		low
phenylalanine arginine beta-naphthylamide	peptide		low
teprotide	peptide		low
ro 09-1437	peptide		low
N-[2-[[2-(cyclopentylamino)-2-oxo-1-pyridin-4-ylethyl]-(thiophen-2-ylmethyl)amino]-2-oxoethyl]-2-furancarboxamide	peptide		low
N-[2-[1,3-benzodioxol-5-yl-[2-(cyclopentylamino)-2-oxo-1-pyridin-4-ylethyl]amino]-2-oxoethyl]-2-furancarboxamide	peptide		low
N-[1-[(1-amino-4-methyl-1-oxopentan-2-yl)amino]-3-methyl-1-oxopentan-2-yl]carbamic acid tert-butyl ester	peptide		low
N-tert-butyl-N-[2-(tert-butylamino)-2-oxoethyl]-3-(3,4-dihydro-2H-quinolin-1-yl)propanamide	peptide		low
N-[2-[1,3-benzodioxol-5-yl-[2-(tert-butylamino)-2-oxo-1-pyridin-4-ylethyl]amino]-2-oxoethyl]-2-furancarboxamide	peptide		low
N-[2-(4-chloro-N-[2-(cyclohexylamino)-2-oxoethyl]anilino)-2-oxoethyl]-2-furancarboxamide	peptide		low
2-[(2-acetamido-1-oxoethyl)amino]-3-phenylpropanoic acid ethyl ester	peptide		low
deltorphin	peptide		low
angiotensin iii, 5-ile-	peptide		low
N-[2-[butyl-[2-(cyclopentylamino)-2-oxo-1-pyridin-4-ylethyl]amino]-2-oxoethyl]-2-thiophenecarboxamide	peptide		low
2-[[2-(cyclohexylamino)-2-oxo-1-thiophen-2-ylethyl]-[1-oxo-2-[[oxo(thiophen-2-yl)methyl]amino]ethyl]amino]acetic acid ethyl ester	peptide		low
N-[2-[[2-(cyclohexylamino)-2-oxo-1-thiophen-2-ylethyl]-(2-methoxyethyl)amino]-2-oxoethyl]-2-furancarboxamide	peptide		low
4-hydroxy-1-[1-oxo-2-(phenylmethoxycarbonylamino)propyl]-2-pyrrolidinecarboxylic acid	peptide		low
4-hydroxy-1-[1-oxo-2-[[1-oxo-2-(phenylmethoxycarbonylamino)ethyl]amino]propyl]-2-pyrrolidinecarboxylic acid (phenylmethyl) ester	peptide		low
2-[(2-acetamido-1-oxoethyl)amino]-N-(4-methoxyphenyl)-2-(4-methylphenyl)acetamide	peptide		low
mureidomycin a	peptide		low
kallidin	peptide		low
delapril	peptide		low
delapril	peptide		low
(2R)-2-[[(2R,3R,4R)-2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-methyl-1-oxobutyl]amino]-2-[(2S,3R,4S,5S)-5-(2,4-dioxo-1-pyrimidinyl)-3,4-dihydroxy-2-oxolanyl]acetic acid	peptide		low
enkephalin, ala(2)-mephe(4)-gly(5)-	peptide		low
l 685458	carbamate ester; monocarboxylic acid amide; peptide; secondary alcohol	EC 3.4.23.46 (memapsin 2) inhibitor; peptidomimetic	low
alvimopan anhydrous	peptide		low
leucokinin i	peptide		low
s-(1,2-dichlorovinyl)glutathione	peptide		low
cyanoginosin-la	peptide		low
(3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-1-oxopropyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid	peptide		low
lenampicillin	peptide		low
glycyl-alanyl-leucine	peptide		low
leucyl-leucine-methyl ester	peptide		low
valyl-valyl-valine	peptide		low
(3S)-N-[2-(2,3-dihydro-1,4-benzodioxin-6-ylamino)-2-oxoethyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide	peptide		low
ly 450139	peptide		low
flag peptide	peptide		low
carbobenzoxy-leucyl-leucyl-norvalinal	peptide		low
l 692585	peptide		low
deltorphin ii, ala(2)-	peptide		low
deltorphin i, ala(2)-	peptide		low
eledoisin	peptide		low
icg 001	peptide		low
darinaparsin	peptide		low
ubenimex	peptide		low
rhizocticin a	peptide		low
(2S)-2-[[[1-[(2S)-3-methyl-2-[(4-methylphenyl)sulfonylamino]-1-oxobutyl]-4-piperidinyl]-oxomethyl]amino]-2-phenylacetic acid	peptide		low
(2R)-2-[[(3S)-3-acetamido-3-carboxy-1-oxopropyl]amino]pentanedioic acid	peptide		low
alamandine	peptide		low
(3S)-3-[[[(2S)-1-[(2S)-2-[[(4-amino-3-chlorophenyl)-oxomethyl]amino]-3,3-dimethyl-1-oxobutyl]-2-pyrrolidinyl]-oxomethyl]amino]-3-cyanopropanoic acid	peptide		low
tuftsin	peptide		low
microcystin	peptide		low
thiocoraline	peptide		low
glutamyl-valyl-glycine	peptide		low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	1990's	2000's	2010's	post-2020
acetic acid	2	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent	2004	2016	14.0	low	0	1	1	0
beta-alanine	1	amino acid zwitterion; beta-amino acid	agonist; fundamental metabolite; human metabolite; inhibitor; neurotransmitter	2017	2017	7.0	low	0	0	1	0
glycine	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical	2011	2011	13.0	low	0	0	1	0
histamine	2	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter	2009	2016	11.5	low	0	1	1	0
porphobilinogen	1	aralkylamino compound; dicarboxylic acid; pyrroles	Escherichia coli metabolite; metabolite; mouse metabolite	2015	2015	9.0	low	0	0	1	0
indomethacin	3	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic	2000	2015	18.7	low	1	1	1	0
nafamostat	1	benzoic acids; guanidines		2009	2009	15.0	low	0	1	0	0
adenosine diphosphate	1	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite	2014	2014	10.0	low	0	0	1	0
arginine	1	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical	2018	2018	6.0	low	0	0	1	0
acrolein	1	enal	herbicide; human xenobiotic metabolite; toxin	2015	2015	9.0	low	0	0	1	0
thiazoles	1	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene		2014	2014	10.0	low	0	0	1	0
acetylcysteine	1	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary	2012	2012	12.0	low	0	0	1	0
sodium hydroxide	3	alkali metal hydroxide		2000	2006	21.7	low	1	2	0	0
phosphine	1	mononuclear parent hydride; phosphanes; phosphine	carcinogenic agent; fumigant insecticide	2021	2021	3.0	low	0	0	0	1
phenyl acetate	1	benzenes; phenyl acetates		2015	2015	9.0	low	0	0	1	0
glutamic acid	2	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical	2007	2014	13.5	low	0	1	1	0
substance p	1	peptide	neurokinin-1 receptor agonist; neurotransmitter; vasodilator agent	2008	2008	16.0	low	0	1	0	0
cefadroxil anhydrous	1	cephalosporin	antibacterial drug	2021	2021	3.0	low	0	0	0	1
prolinal	1	pyrrolidines		2019	2019	5.0	low	0	0	1	0
fibrinogen	1	iditol	fungal metabolite	2000	2000	24.0	low	1	0	0	0
glycyl-prolyl-glycyl-glycine	2			1998	1998	26.0	high	2	0	0	0
carbobenzoxyproline	1			2019	2019	5.0	medium	0	0	1	0
p-methoxy-n-methylphenethylamine	1	aromatic ether; secondary amino compound	metabolite	2012	2012	12.0	low	0	0	1	0
cyclo(prolylglycyl)	1			2019	2019	5.0	low	0	0	1	0
proline	85	amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid	algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite	1998	2022	12.7	high	7	27	47	4
carbocysteine	1	L-cysteine thioether; non-proteinogenic L-alpha-amino acid	mucolytic	2012	2012	12.0	low	0	0	1	0
fibrin	1	peptide		2000	2000	24.0	low	1	0	0	0
arachidonic acid	1	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite	2014	2014	10.0	low	0	0	1	0
tetragastrin	1	peptidyl amide; tetrapeptide	anxiogenic; human metabolite	2008	2008	16.0	low	0	1	0	0
glycylproline	7	dipeptide zwitterion; dipeptide	metabolite	1998	2019	16.7	medium	1	4	2	0
leukotriene a4	2	epoxy fatty acid; leukotriene; long-chain fatty acid; oxylipin; polyunsaturated fatty acid	human metabolite; mouse metabolite; plant metabolite	2015	2015	9.0	low	0	0	2	0
leukotriene b4	4	dihydroxy monocarboxylic acid; hydroxy polyunsaturated fatty acid; leukotriene; long-chain fatty acid	human metabolite; mouse metabolite; plant metabolite; vasoconstrictor agent	2010	2017	11.0	low	0	2	2	0
prolylglycine	5	dipeptide zwitterion; dipeptide		1998	2014	21.6	medium	2	2	1	0
acth (4-7), pro-gly-pro-	9			2001	2017	12.9	medium	0	3	6	0
sc 57461	1			2017	2017	7.0	low	0	0	1	0
seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide	1			2009	2009	15.0	low	0	1	0	0
tp 7	1			2017	2017	7.0	low	0	0	1	0
neuropeptide y	1			2008	2008	16.0	low	0	1	0	0
endothelin-1	1			2017	2017	7.0	low	0	0	1	0
interleukin-8	4			2009	2013	13.0	low	0	1	3	0
chymostatin	1			2009	2009	15.0	low	0	1	0	0
vasoactive intestinal peptide	3			2008	2009	15.7	low	0	3	0	0

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	1990's	2000's	2010's	post-2020
2019 Novel Coronavirus Disease	1	2021	2021	3.0	low	0	0	0	1
Ache	1	2018	2018	6.0	low	0	0	1	0
Acute Lung Injury	1	2021	2021	3.0	low	0	0	0	1
Acute Respiratory Distress Syndrome	1	2018	2018	6.0	low	0	0	1	0
Aggression	1	2018	2018	6.0	low	0	0	1	0
Airflow Obstruction, Chronic	5	2010	2019	10.6	low	0	2	3	0
Airway Hyper-Responsiveness	1	2018	2018	6.0	low	0	0	1	0
Airway Obstruction	1	2014	2014	10.0	low	0	0	1	0
Airway Remodeling	3	2018	2020	5.3	low	0	0	3	0
Allergic Reaction	1	2018	2018	6.0	low	0	0	1	0
Amnionitis	1	2017	2017	7.0	low	0	0	1	0
Analgesia, Congenital	1	2009	2009	15.0	low	0	1	0	0
Anasarca	1	2016	2016	8.0	low	0	0	1	0
Angiitis	1	2017	2017	7.0	low	0	0	1	0
Anoxemia	1	2006	2006	18.0	low	0	1	0	0
Anxiety	3	2004	2022	12.7	low	0	2	0	1
Apoplexy	1	2019	2019	5.0	low	0	0	1	0
Asthma	2	2014	2018	8.0	low	0	0	2	0
Asthma, Bronchial	2	2014	2018	8.0	low	0	0	2	0
Bacterial Pneumonia	1	2015	2015	9.0	low	0	0	1	0
Behavior Disorders	1	2006	2006	18.0	low	0	1	0	0
Blood Poisoning	1	2011	2011	13.0	low	0	0	1	0
Bowel Diseases, Inflammatory	1	2019	2019	5.0	low	0	0	1	0
Brain Ischemia	3	2005	2017	13.0	low	0	1	2	0
Bronchiolitis Obliterans	1	2009	2009	15.0	low	0	1	0	0
Bronchiolitis, Exudative	1	2009	2009	15.0	low	0	1	0	0
Burns, Chemical	3	2000	2006	21.7	low	1	2	0	0
Centriacinar Emphysema	2	2011	2019	9.0	low	0	0	2	0
Cerebral Infarction, Middle Cerebral Artery	1	2013	2013	11.0	low	0	0	1	0
Cerebral Ischemia	3	2005	2017	13.0	low	0	1	2	0
Chorioamnionitis	1	2017	2017	7.0	low	0	0	1	0
Chronic Disease	4	2008	2015	12.8	low	0	1	3	0
Chronic Illness	4	2008	2015	12.8	low	0	1	3	0
Chronic Lung Injury	1	2018	2018	6.0	low	0	0	1	0
Complications, Infectious Pregnancy	1	2017	2017	7.0	low	0	0	1	0
Cornea Injuries	1	2000	2000	24.0	low	1	0	0	0
Corneal Injuries	1	2000	2000	24.0	low	1	0	0	0
Corneal Ulcer	2	2001	2006	20.5	low	0	2	0	0
Cystic Fibrosis	2	2008	2020	10.0	low	0	1	1	0
Cystic Fibrosis of Pancreas	2	2008	2020	10.0	low	0	1	1	0
Degenerative Diseases, Central Nervous System	1	2021	2021	3.0	low	0	0	0	1
Delayed Effects, Prenatal Exposure	1	2006	2006	18.0	low	0	1	0	0
Depression	1	2008	2008	16.0	low	0	1	0	0
Disbacteriosis	1	2022	2022	2.0	low	0	0	0	1
Disease Models, Animal	10	2003	2021	12.4	low	0	4	5	1
Disease, Pulmonary	3	2011	2018	10.7	low	0	0	3	0
Edema	1	2016	2016	8.0	low	0	0	1	0
Elevated Cholesterol	1	2013	2013	11.0	low	0	0	1	0
Equine Diseases	1	2014	2014	10.0	low	0	0	1	0
Experimental Lung Inflammation	3	2010	2017	11.7	low	0	2	1	0
Eye Burns	3	2000	2006	21.7	low	1	2	0	0
Fetal Membranes, Premature Rupture	1	2017	2017	7.0	low	0	0	1	0
Gastric Ulcer	5	1999	2016	15.2	low	1	2	2	0
Gastritis	1	2015	2015	9.0	low	0	0	1	0
Haemophilus Infections	1	2015	2015	9.0	low	0	0	1	0
Hypercholesterolemia	1	2013	2013	11.0	low	0	0	1	0
Hyperhidrosis	1	2009	2009	15.0	low	0	1	0	0
Hyperidrosis	1	2009	2009	15.0	low	0	1	0	0
Hypersensitivity	1	2018	2018	6.0	low	0	0	1	0
Hypoxia	1	2006	2006	18.0	low	0	1	0	0
Infarction, Middle Cerebral Artery	1	2013	2013	11.0	low	0	0	1	0
Infections, Orthomyxoviridae	2	2010	2010	14.0	low	0	2	0	0
Infections, Pneumococcal	2	2010	2010	14.0	low	0	2	0	0
Infections, Ureaplasma	1	2017	2017	7.0	low	0	0	1	0
Inflammation	19	2006	2021	9.9	low	0	5	13	1
Inflammatory Bowel Diseases	1	2019	2019	5.0	low	0	0	1	0
Injuries	1	2017	2017	7.0	low	0	0	1	0
Innate Inflammatory Response	19	2006	2021	9.9	low	0	5	13	1
Keratitis	1	2008	2008	16.0	low	0	1	0	0
Keratitis, Ulcerative	2	2001	2006	20.5	low	0	2	0	0
Lung Diseases	3	2011	2018	10.7	low	0	0	3	0
Lung Injury, Acute	1	2021	2021	3.0	low	0	0	0	1
Mental Disorders	1	2006	2006	18.0	low	0	1	0	0
Neurodegenerative Diseases	1	2021	2021	3.0	low	0	0	0	1
Orthomyxoviridae Infections	2	2010	2010	14.0	low	0	2	0	0
Pain	1	2018	2018	6.0	low	0	0	1	0
Peritonitis	1	2007	2007	17.0	low	0	1	0	0
Pheochromocytoma	1	2015	2015	9.0	low	0	0	1	0
Pheochromocytoma, Extra-Adrenal	1	2015	2015	9.0	low	0	0	1	0
Pneumococcal Infections	2	2010	2010	14.0	low	0	2	0	0
Pneumonia	3	2010	2017	11.7	low	0	2	1	0
Pneumonia, Bacterial	1	2015	2015	9.0	low	0	0	1	0
Pneumonia, Pneumococcal	1	2015	2015	9.0	low	0	0	1	0
Pregnancy	2	2006	2017	12.5	low	0	1	1	0
Premature Rupture of Fetal Membranes	1	2017	2017	7.0	low	0	0	1	0
Primary Peritonitis	1	2007	2007	17.0	low	0	1	0	0
Protein Aggregation, Pathological	1	2021	2021	3.0	low	0	0	0	1
Pulmonary Disease, Chronic Obstructive	5	2010	2019	10.6	low	0	2	3	0
Respiratory Distress Syndrome	1	2018	2018	6.0	low	0	0	1	0
Rida	1	2008	2008	16.0	low	0	1	0	0
Sepsis	1	2011	2011	13.0	low	0	0	1	0
Stomach Ulcer	5	1999	2016	15.2	low	1	2	2	0
Stroke	1	2019	2019	5.0	low	0	0	1	0
Vasculitis	1	2017	2017	7.0	low	0	0	1	0
Wounds and Injuries	1	2017	2017	7.0	low	0	0	1	0

Binding of Glyprolines to L-Arginine Inverts Its Analgesic and Antiagressogenic Effects.
Bulletin of experimental biology and medicine, , Volume: 165, Issue:5, 2018

Peptidergic correction of behavior in adult progeny of albino rats exposed to acute hypoxia during early organogenesis.
Bulletin of experimental biology and medicine, , Volume: 142, Issue:1, 2006

ACTH(6-9)-Pro-Gly-Pro ameliorates anxiety-like and depressive-like behaviour and gut mucosal microbiota composition in rats under conditions of chronic restraint stress.
Neuropeptides, , Volume: 93, 2022

Protective and therapeutic effects of glyprolines in psychoemotional stress induced by cholecystokinin-4 injection.
Bulletin of experimental biology and medicine, , Volume: 145, Issue:3, 2008

Effect of peptide Pro-Gly-Pro on stress-induced behavioral changes in rats.
Bulletin of experimental biology and medicine, , Volume: 138, Issue:1, 2004

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Science translational medicine, , 08-22, Volume: 10, Issue:455, 2018

Airway collagen and elastic fiber content correlates with lung function in equine heaves.
American journal of physiology. Lung cellular and molecular physiology, , Aug-01, Volume: 307, Issue:3, 2014

Peptidergic correction of behavior in adult progeny of albino rats exposed to acute hypoxia during early organogenesis.
Bulletin of experimental biology and medicine, , Volume: 142, Issue:1, 2006

The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation.
Journal of immunology (Baltimore, Md. : 1950), , Apr-01, Volume: 182, Issue:7, 2009

Semax, an analog of ACTH
Molecular genetics and genomics : MGG, , Volume: 292, Issue:3, 2017

The effect of Semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study.
Journal of molecular neuroscience : MN, , Volume: 45, Issue:2, 2011

C-terminal Pro-Gly-Pro tripeptide in contrast to full-length neuropeptide semax exhibits no neuroprotective effect in experimental cerebral ischemia.
Bulletin of experimental biology and medicine, , Volume: 139, Issue:4, 2005

[The effect of semax and its C-end peptide PGP on Vegfa gene expression in the rat brain during incomplete global ischemia].
Molekuliarnaia biologiia, , Volume: 47, Issue:3

[The effect of semax and its C-end peptide PGP on expression of the neurotrophins and their receptors in the rat brain during incomplete global ischemia].
Molekuliarnaia biologiia, , Volume: 45, Issue:6

The effect of semax and the C-terminal peptide PGP on expression of growth factor genes and receptors in rats under conditions of experimental cerebral ischemia.
Doklady. Biochemistry and biophysics, , Volume: 422

[Effect of tripeptide Pro-Gly-Pro on rat brain transcriptome in focal ischemia].
Molekuliarnaia biologiia, , Volume: 48, Issue:2

[Effect of tripeptide Pro-Gly-Pro on rat brain transcriptome in focal ischemia].
Molekuliarnaia biologiia, , Volume: 48, Issue:2

Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: a novel mechanism of preterm rupture of membranes and chorioamnionitis.
Pediatric research, , Volume: 81, Issue:1-1, 2017

A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation.
Inflammation, , Volume: 38, Issue:6, 2015

Targeting of a common receptor shared by CXCL8 and N-Ac-PGP as a therapeutic strategy to alleviate chronic neutrophilic lung diseases.
European journal of pharmacology, , Sep-30, Volume: 667, Issue:1-3, 2011

A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation.
PloS one, , Jan-13, Volume: 6, Issue:1, 2011

A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.
Journal of immunology (Baltimore, Md. : 1950), , Apr-15, Volume: 180, Issue:8, 2008

L-arginine-threonine-arginine (RTR) tetramer peptide inhibits ulceration in the alkali-injured rabbit cornea.
Cornea, , Volume: 25, Issue:10, 2006

Inhibitory effect of a complementary peptide on ulceration in the alkali-injured rabbit cornea.
Investigative ophthalmology & visual science, , Volume: 42, Issue:12, 2001

Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, , Volume: 19, Issue:1, 2020

A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.
Journal of immunology (Baltimore, Md. : 1950), , Apr-15, Volume: 180, Issue:8, 2008

Protective and therapeutic effects of glyprolines in psychoemotional stress induced by cholecystokinin-4 injection.
Bulletin of experimental biology and medicine, , Volume: 145, Issue:3, 2008

[EFFECT OF THE PROLYL-GLYCIL-PROLINE (PGP) AND ITS ACETYLATED FORM (N-AcPGP) ON PERMEABILITY OF SKIN VESSELS IN RATS].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, , Volume: 102, Issue:9, 2016

L-arginine-threonine-arginine (RTR) tetramer peptide inhibits ulceration in the alkali-injured rabbit cornea.
Cornea, , Volume: 25, Issue:10, 2006

Inhibitory effect of a complementary peptide on ulceration in the alkali-injured rabbit cornea.
Investigative ophthalmology & visual science, , Volume: 42, Issue:12, 2001

Synthetic complementary peptides inhibit a neutrophil chemoattractant found in the alkali-injured cornea.
Cornea, , Volume: 19, Issue:3, 2000

Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: a novel mechanism of preterm rupture of membranes and chorioamnionitis.
Pediatric research, , Volume: 81, Issue:1-1, 2017

Effects of Glyprolines on DNA Synthesis and Free Radical Oxidation in Mouse Gastric Mucosa Under Physiological Conditions and During Therapy with Oral Non-Steroid Anti-Inflammatory Drugs.
Bulletin of experimental biology and medicine, , Volume: 159, Issue:4, 2015

Effect of the PRO-GLY-PRO peptide on hemostasis and lipid metabolism in rats with hypercholesterolemia.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, , Volume: 453, 2013

Absence of pain with hyperhidrosis: a new syndrome where vascular afferents may mediate cutaneous sensation.
Pain, , Dec-15, Volume: 147, Issue:1-3, 2009

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Science translational medicine, , 08-22, Volume: 10, Issue:455, 2018

A mechanism for matrikine regulation in acute inflammatory lung injury.
JCI insight, , 04-08, Volume: 6, Issue:7, 2021

Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, , Volume: 19, Issue:1, 2020

Proline-Glycine-Proline Peptides Are Critical in the Development of Smoke-induced Emphysema.
American journal of respiratory cell and molecular biology, , Volume: 61, Issue:5, 2019

Benzyloxycarbonyl-proline-prolinal (ZPP): Dual complementary roles for neutrophil inhibition.
Biochemical and biophysical research communications, , 10-01, Volume: 517, Issue:4, 2019

The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome.
American journal of physiology. Lung cellular and molecular physiology, , 11-01, Volume: 315, Issue:5, 2018

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Science translational medicine, , 08-22, Volume: 10, Issue:455, 2018

The development of novel LTA
Scientific reports, , 03-17, Volume: 7, 2017

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.
Nature communications, , Sep-24, Volume: 6, 2015

A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation.
Inflammation, , Volume: 38, Issue:6, 2015

Airway collagen and elastic fiber content correlates with lung function in equine heaves.
American journal of physiology. Lung cellular and molecular physiology, , Aug-01, Volume: 307, Issue:3, 2014

Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Proceedings of the National Academy of Sciences of the United States of America, , Mar-18, Volume: 111, Issue:11, 2014

Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation?
PloS one, , Volume: 8, Issue:1, 2013

Tripeptide Pro-Gly-Pro prevents disturbances in osmotic resistance of rat erythrocytes under conditions of inflammation.
Bulletin of experimental biology and medicine, , Volume: 153, Issue:3, 2012

A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation.
PloS one, , Jan-13, Volume: 6, Issue:1, 2011

Medicine. Neutrophils find smoke attractive.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.
Journal of immunology (Baltimore, Md. : 1950), , Apr-15, Volume: 180, Issue:8, 2008

Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro.
The American journal of pathology, , Volume: 173, Issue:1, 2008

Reply to 'A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation'.
Nature medicine, , Volume: 12, Issue:6, 2006

Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro.
The American journal of pathology, , Volume: 173, Issue:1, 2008

The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease.
European respiratory review : an official journal of the European Respiratory Society, , Jun-30, Volume: 27, Issue:148, 2018

Targeting of a common receptor shared by CXCL8 and N-Ac-PGP as a therapeutic strategy to alleviate chronic neutrophilic lung diseases.
European journal of pharmacology, , Sep-30, Volume: 667, Issue:1-3, 2011

Leukotriene A4 hydrolase: an anti-inflammatory role for a proinflammatory enzyme.
Thorax, , Volume: 66, Issue:6, 2011

Medicine. Neutrophils find smoke attractive.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

Binding of Glyprolines to L-Arginine Inverts Its Analgesic and Antiagressogenic Effects.
Bulletin of experimental biology and medicine, , Volume: 165, Issue:5, 2018

Peptide correction of disorders in rat mesenteric microcirculatory system during inflammation.
Bulletin of experimental biology and medicine, , Volume: 144, Issue:1, 2007

Synthesis of a new fluorescent analogue of proglyprol and study of the mechanisms of its transport into the cultured rat pheochromocytoma cells.
Doklady. Biochemistry and biophysics, , Volume: 460, 2015

Medicine. Neutrophils find smoke attractive.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors.
Scientific reports, , 10-19, Volume: 7, Issue:1, 2017

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

Medicine. Neutrophils find smoke attractive.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.
Nature communications, , Sep-24, Volume: 6, 2015

Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: a novel mechanism of preterm rupture of membranes and chorioamnionitis.
Pediatric research, , Volume: 81, Issue:1-1, 2017

Peptidergic correction of behavior in adult progeny of albino rats exposed to acute hypoxia during early organogenesis.
Bulletin of experimental biology and medicine, , Volume: 142, Issue:1, 2006

The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome.
American journal of physiology. Lung cellular and molecular physiology, , 11-01, Volume: 315, Issue:5, 2018

Glyprolines exert protective and repair-promoting effects in the rat stomach: potential role of the cytokine GRO/CINC-1.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, , Volume: 67, Issue:2, 2016

Correlation analysis of cytokine gene expression changes and antiulcer effects of Pro-Gly-Pro and N-Acetyl-Pro-Gly-Pro in experimental models of ulceration.
Doklady. Biochemistry and biophysics, , Volume: 465, 2015

Effect of glyprolines on homeostasis of gastric mucosa in rats with stress ulcers.
Bulletin of experimental biology and medicine, , Volume: 149, Issue:1, 2010

[Protective effect of the intraperitoneal and intragastric administration of PGP-peptide on ethanol-induced erosions and acetate-induced ulcers in rats].
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, , Issue:4, 2004

[Protective effect of peptide PGP on gastric mucosa].
Doklady Akademii nauk, , Volume: 368, Issue:5, 1999

[Effects of glyprolines on development and healing of acetate ulcers in rats].
Patologicheskaia fiziologiia i eksperimental'naia terapiia, , Issue:2

The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac Rejection.
Scientific reports, , 08-08, Volume: 7, Issue:1, 2017

N-Acetylated Proline-Glycine-Proline Accelerates Cutaneous Wound Healing and Neovascularization by Human Endothelial Progenitor Cells.
Scientific reports, , 02-23, Volume: 7, 2017

Proline-containing peptides-New insight and implications: A Review.
BioFactors (Oxford, England), , Volume: 45, Issue:6, 2019

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.
Nature communications, , Sep-24, Volume: 6, 2015

Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis.
American journal of respiratory and critical care medicine, , Jul-15, Volume: 184, Issue:2, 2011

Phosphine modification of proline-glycine-proline tripeptide and study of its neuroprotective properties.
Biochemical and biophysical research communications, , 02-05, Volume: 539, 2021

Effect of semax and its C-terminal fragment Pro-Gly-Pro on the expression of VEGF family genes and their receptors in experimental focal ischemia of the rat brain.
Journal of molecular neuroscience : MN, , Volume: 49, Issue:2, 2013

Proline-containing peptides-New insight and implications: A Review.
BioFactors (Oxford, England), , Volume: 45, Issue:6, 2019

Proline-Glycine-Proline Peptides Are Critical in the Development of Smoke-induced Emphysema.
American journal of respiratory cell and molecular biology, , Volume: 61, Issue:5, 2019

The matrikine PGP as a potential biomarker in COPD.
American journal of physiology. Lung cellular and molecular physiology, , Jun-01, Volume: 308, Issue:11, 2015

Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation?
PloS one, , Volume: 8, Issue:1, 2013

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

Medicine. Neutrophils find smoke attractive.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

A mechanism for matrikine regulation in acute inflammatory lung injury.
JCI insight, , 04-08, Volume: 6, Issue:7, 2021

Synthetic complementary peptides inhibit a neutrophil chemoattractant found in the alkali-injured cornea.
Cornea, , Volume: 19, Issue:3, 2000

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.
Nature communications, , Sep-24, Volume: 6, 2015

Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis.
American journal of respiratory and critical care medicine, , Jul-15, Volume: 184, Issue:2, 2011

Phosphine modification of proline-glycine-proline tripeptide and study of its neuroprotective properties.
Biochemical and biophysical research communications, , 02-05, Volume: 539, 2021

Effect of semax and its C-terminal fragment Pro-Gly-Pro on the expression of VEGF family genes and their receptors in experimental focal ischemia of the rat brain.
Journal of molecular neuroscience : MN, , Volume: 49, Issue:2, 2013

Proline-containing peptides-New insight and implications: A Review.
BioFactors (Oxford, England), , Volume: 45, Issue:6, 2019

Proline-Glycine-Proline Peptides Are Critical in the Development of Smoke-induced Emphysema.
American journal of respiratory cell and molecular biology, , Volume: 61, Issue:5, 2019

The matrikine PGP as a potential biomarker in COPD.
American journal of physiology. Lung cellular and molecular physiology, , Jun-01, Volume: 308, Issue:11, 2015

Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation?
PloS one, , Volume: 8, Issue:1, 2013

Medicine. Neutrophils find smoke attractive.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome.
American journal of physiology. Lung cellular and molecular physiology, , 11-01, Volume: 315, Issue:5, 2018

A mechanism for matrikine regulation in acute inflammatory lung injury.
JCI insight, , 04-08, Volume: 6, Issue:7, 2021

Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, , Volume: 19, Issue:1, 2020

The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease.
European respiratory review : an official journal of the European Respiratory Society, , Jun-30, Volume: 27, Issue:148, 2018

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Science translational medicine, , 08-22, Volume: 10, Issue:455, 2018

ACTH(6-9)-Pro-Gly-Pro ameliorates anxiety-like and depressive-like behaviour and gut mucosal microbiota composition in rats under conditions of chronic restraint stress.
Neuropeptides, , Volume: 93, 2022

Synthetic complementary peptides inhibit a neutrophil chemoattractant found in the alkali-injured cornea.
Cornea, , Volume: 19, Issue:3, 2000

Phosphine modification of proline-glycine-proline tripeptide and study of its neuroprotective properties.
Biochemical and biophysical research communications, , 02-05, Volume: 539, 2021

A mechanism for matrikine regulation in acute inflammatory lung injury.
JCI insight, , 04-08, Volume: 6, Issue:7, 2021

Airway collagen and elastic fiber content correlates with lung function in equine heaves.
American journal of physiology. Lung cellular and molecular physiology, , Aug-01, Volume: 307, Issue:3, 2014

Absence of pain with hyperhidrosis: a new syndrome where vascular afferents may mediate cutaneous sensation.
Pain, , Dec-15, Volume: 147, Issue:1-3, 2009

Peptidergic correction of behavior in adult progeny of albino rats exposed to acute hypoxia during early organogenesis.
Bulletin of experimental biology and medicine, , Volume: 142, Issue:1, 2006

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Science translational medicine, , 08-22, Volume: 10, Issue:455, 2018

Airway collagen and elastic fiber content correlates with lung function in equine heaves.
American journal of physiology. Lung cellular and molecular physiology, , Aug-01, Volume: 307, Issue:3, 2014

Peptidergic correction of behavior in adult progeny of albino rats exposed to acute hypoxia during early organogenesis.
Bulletin of experimental biology and medicine, , Volume: 142, Issue:1, 2006

The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation.
Journal of immunology (Baltimore, Md. : 1950), , Apr-01, Volume: 182, Issue:7, 2009

L-arginine-threonine-arginine (RTR) tetramer peptide inhibits ulceration in the alkali-injured rabbit cornea.
Cornea, , Volume: 25, Issue:10, 2006

Inhibitory effect of a complementary peptide on ulceration in the alkali-injured rabbit cornea.
Investigative ophthalmology & visual science, , Volume: 42, Issue:12, 2001

Synthetic complementary peptides inhibit a neutrophil chemoattractant found in the alkali-injured cornea.
Cornea, , Volume: 19, Issue:3, 2000

Semax, an analog of ACTH
Molecular genetics and genomics : MGG, , Volume: 292, Issue:3, 2017

The effect of Semax and its C-end peptide PGP on the morphology and proliferative activity of rat brain cells during experimental ischemia: a pilot study.
Journal of molecular neuroscience : MN, , Volume: 45, Issue:2, 2011

C-terminal Pro-Gly-Pro tripeptide in contrast to full-length neuropeptide semax exhibits no neuroprotective effect in experimental cerebral ischemia.
Bulletin of experimental biology and medicine, , Volume: 139, Issue:4, 2005

[Effect of tripeptide Pro-Gly-Pro on rat brain transcriptome in focal ischemia].
Molekuliarnaia biologiia, , Volume: 48, Issue:2

[The effect of semax and its C-end peptide PGP on expression of the neurotrophins and their receptors in the rat brain during incomplete global ischemia].
Molekuliarnaia biologiia, , Volume: 45, Issue:6

[The effect of semax and its C-end peptide PGP on Vegfa gene expression in the rat brain during incomplete global ischemia].
Molekuliarnaia biologiia, , Volume: 47, Issue:3

The effect of semax and the C-terminal peptide PGP on expression of growth factor genes and receptors in rats under conditions of experimental cerebral ischemia.
Doklady. Biochemistry and biophysics, , Volume: 422

[Effect of tripeptide Pro-Gly-Pro on rat brain transcriptome in focal ischemia].
Molekuliarnaia biologiia, , Volume: 48, Issue:2

Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: a novel mechanism of preterm rupture of membranes and chorioamnionitis.
Pediatric research, , Volume: 81, Issue:1-1, 2017

A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation.
Inflammation, , Volume: 38, Issue:6, 2015

Targeting of a common receptor shared by CXCL8 and N-Ac-PGP as a therapeutic strategy to alleviate chronic neutrophilic lung diseases.
European journal of pharmacology, , Sep-30, Volume: 667, Issue:1-3, 2011

A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation.
PloS one, , Jan-13, Volume: 6, Issue:1, 2011

A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.
Journal of immunology (Baltimore, Md. : 1950), , Apr-15, Volume: 180, Issue:8, 2008

L-arginine-threonine-arginine (RTR) tetramer peptide inhibits ulceration in the alkali-injured rabbit cornea.
Cornea, , Volume: 25, Issue:10, 2006

Inhibitory effect of a complementary peptide on ulceration in the alkali-injured rabbit cornea.
Investigative ophthalmology & visual science, , Volume: 42, Issue:12, 2001

Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, , Volume: 19, Issue:1, 2020

A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.
Journal of immunology (Baltimore, Md. : 1950), , Apr-15, Volume: 180, Issue:8, 2008

A mechanism for matrikine regulation in acute inflammatory lung injury.
JCI insight, , 04-08, Volume: 6, Issue:7, 2021

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Science translational medicine, , 08-22, Volume: 10, Issue:455, 2018

Semax, an analog of ACTH
Molecular genetics and genomics : MGG, , Volume: 292, Issue:3, 2017

N-Acetylated Proline-Glycine-Proline Accelerates Cutaneous Wound Healing and Neovascularization by Human Endothelial Progenitor Cells.
Scientific reports, , 02-23, Volume: 7, 2017

Activation of CXCR2 by extracellular matrix degradation product acetylated Pro-Gly-Pro has therapeutic effects against sepsis.
American journal of respiratory and critical care medicine, , Jul-15, Volume: 184, Issue:2, 2011

Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown.
American journal of physiology. Lung cellular and molecular physiology, , Volume: 300, Issue:2, 2011

Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie.
Acta neuropathologica, , Volume: 115, Issue:6, 2008

L-arginine-threonine-arginine (RTR) tetramer peptide inhibits ulceration in the alkali-injured rabbit cornea.
Cornea, , Volume: 25, Issue:10, 2006

[Protective effect of the intraperitoneal and intragastric administration of PGP-peptide on ethanol-induced erosions and acetate-induced ulcers in rats].
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, , Issue:4, 2004

Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax.
Bulletin of experimental biology and medicine, , Volume: 136, Issue:4, 2003

[EFFECT OF THE PROLYL-GLYCIL-PROLINE (PGP) AND ITS ACETYLATED FORM (N-AcPGP) ON PERMEABILITY OF SKIN VESSELS IN RATS].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, , Volume: 102, Issue:9, 2016

Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: a novel mechanism of preterm rupture of membranes and chorioamnionitis.
Pediatric research, , Volume: 81, Issue:1-1, 2017

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.
Nature communications, , Sep-24, Volume: 6, 2015

Airway collagen and elastic fiber content correlates with lung function in equine heaves.
American journal of physiology. Lung cellular and molecular physiology, , Aug-01, Volume: 307, Issue:3, 2014

Effect of the PRO-GLY-PRO peptide on hemostasis and lipid metabolism in rats with hypercholesterolemia.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, , Volume: 453, 2013

Absence of pain with hyperhidrosis: a new syndrome where vascular afferents may mediate cutaneous sensation.
Pain, , Dec-15, Volume: 147, Issue:1-3, 2009

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Science translational medicine, , 08-22, Volume: 10, Issue:455, 2018

A mechanism for matrikine regulation in acute inflammatory lung injury.
JCI insight, , 04-08, Volume: 6, Issue:7, 2021

Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, , Volume: 19, Issue:1, 2020

Proline-Glycine-Proline Peptides Are Critical in the Development of Smoke-induced Emphysema.
American journal of respiratory cell and molecular biology, , Volume: 61, Issue:5, 2019

Benzyloxycarbonyl-proline-prolinal (ZPP): Dual complementary roles for neutrophil inhibition.
Biochemical and biophysical research communications, , 10-01, Volume: 517, Issue:4, 2019

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Science translational medicine, , 08-22, Volume: 10, Issue:455, 2018

The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome.
American journal of physiology. Lung cellular and molecular physiology, , 11-01, Volume: 315, Issue:5, 2018

The development of novel LTA
Scientific reports, , 03-17, Volume: 7, 2017

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.
Nature communications, , Sep-24, Volume: 6, 2015

A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation.
Inflammation, , Volume: 38, Issue:6, 2015

Airway collagen and elastic fiber content correlates with lung function in equine heaves.
American journal of physiology. Lung cellular and molecular physiology, , Aug-01, Volume: 307, Issue:3, 2014

Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor.
Proceedings of the National Academy of Sciences of the United States of America, , Mar-18, Volume: 111, Issue:11, 2014

Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation?
PloS one, , Volume: 8, Issue:1, 2013

Tripeptide Pro-Gly-Pro prevents disturbances in osmotic resistance of rat erythrocytes under conditions of inflammation.
Bulletin of experimental biology and medicine, , Volume: 153, Issue:3, 2012

A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation.
PloS one, , Jan-13, Volume: 6, Issue:1, 2011

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

Medicine. Neutrophils find smoke attractive.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro.
The American journal of pathology, , Volume: 173, Issue:1, 2008

A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.
Journal of immunology (Baltimore, Md. : 1950), , Apr-15, Volume: 180, Issue:8, 2008

Reply to 'A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation'.
Nature medicine, , Volume: 12, Issue:6, 2006

The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease.
European respiratory review : an official journal of the European Respiratory Society, , Jun-30, Volume: 27, Issue:148, 2018

Leukotriene A4 hydrolase: an anti-inflammatory role for a proinflammatory enzyme.
Thorax, , Volume: 66, Issue:6, 2011

Targeting of a common receptor shared by CXCL8 and N-Ac-PGP as a therapeutic strategy to alleviate chronic neutrophilic lung diseases.
European journal of pharmacology, , Sep-30, Volume: 667, Issue:1-3, 2011

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

Medicine. Neutrophils find smoke attractive.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

Binding of Glyprolines to L-Arginine Inverts Its Analgesic and Antiagressogenic Effects.
Bulletin of experimental biology and medicine, , Volume: 165, Issue:5, 2018

Peptide correction of disorders in rat mesenteric microcirculatory system during inflammation.
Bulletin of experimental biology and medicine, , Volume: 144, Issue:1, 2007

Synthesis of a new fluorescent analogue of proglyprol and study of the mechanisms of its transport into the cultured rat pheochromocytoma cells.
Doklady. Biochemistry and biophysics, , Volume: 460, 2015

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

Medicine. Neutrophils find smoke attractive.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors.
Scientific reports, , 10-19, Volume: 7, Issue:1, 2017

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

Medicine. Neutrophils find smoke attractive.
Science (New York, N.Y.), , Oct-01, Volume: 330, Issue:6000, 2010

Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: a novel mechanism of preterm rupture of membranes and chorioamnionitis.
Pediatric research, , Volume: 81, Issue:1-1, 2017

Peptidergic correction of behavior in adult progeny of albino rats exposed to acute hypoxia during early organogenesis.
Bulletin of experimental biology and medicine, , Volume: 142, Issue:1, 2006

Proline-Glycine-Proline Peptides Are Critical in the Development of Smoke-induced Emphysema.
American journal of respiratory cell and molecular biology, , Volume: 61, Issue:5, 2019

Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown.
American journal of physiology. Lung cellular and molecular physiology, , Volume: 300, Issue:2, 2011

The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome.
American journal of physiology. Lung cellular and molecular physiology, , 11-01, Volume: 315, Issue:5, 2018

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.
Science translational medicine, , 08-22, Volume: 10, Issue:455, 2018

Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie.
Acta neuropathologica, , Volume: 115, Issue:6, 2008

Glyprolines exert protective and repair-promoting effects in the rat stomach: potential role of the cytokine GRO/CINC-1.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, , Volume: 67, Issue:2, 2016

Correlation analysis of cytokine gene expression changes and antiulcer effects of Pro-Gly-Pro and N-Acetyl-Pro-Gly-Pro in experimental models of ulceration.
Doklady. Biochemistry and biophysics, , Volume: 465, 2015

Effect of glyprolines on homeostasis of gastric mucosa in rats with stress ulcers.
Bulletin of experimental biology and medicine, , Volume: 149, Issue:1, 2010

[Protective effect of the intraperitoneal and intragastric administration of PGP-peptide on ethanol-induced erosions and acetate-induced ulcers in rats].
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, , Issue:4, 2004

[Protective effect of peptide PGP on gastric mucosa].
Doklady Akademii nauk, , Volume: 368, Issue:5, 1999

[Effects of glyprolines on development and healing of acetate ulcers in rats].
Patologicheskaia fiziologiia i eksperimental'naia terapiia, , Issue:2

The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac Rejection.
Scientific reports, , 08-08, Volume: 7, Issue:1, 2017

N-Acetylated Proline-Glycine-Proline Accelerates Cutaneous Wound Healing and Neovascularization by Human Endothelial Progenitor Cells.
Scientific reports, , 02-23, Volume: 7, 2017

Proline-containing peptides-New insight and implications: A Review.
BioFactors (Oxford, England), , Volume: 45, Issue:6, 2019

Ureaplasma infection-mediated release of matrix metalloproteinase-9 and PGP: a novel mechanism of preterm rupture of membranes and chorioamnionitis.
Pediatric research, , Volume: 81, Issue:1-1, 2017

prolyl-glycyl-proline

Description

Cross-References

Synonyms (5)

Drug Classes (1)

Research

Studies (85)

Study Types

Safety/Toxicity (1)

Pharmacokinetics (1)

Bioavailability (2)

prolyl-glycyl-proline

Description

Cross-References

Synonyms (5)

Drug Classes (1)

Research

Studies (85)

Study Types

Related Drugs (123)

Drugs in this Class (83)

Drugs Researched Together (42)

Related Conditions (95)

Safety/Toxicity (1)

Pharmacokinetics (1)

Bioavailability (2)