Page last updated: 2024-12-07

isovaline

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

isovaline: RN given refers to parent cpd(L)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID94744
SCHEMBL ID23348
MeSH IDM0101928

Synonyms (50)

Synonym
(dl)-2-amino-2-methyl-butanoic acid
2-amino-2-methylbutyric acid
isovaline
2-amino-2-methylbutanoate
.alpha.-amino-.alpha.-methylbutyric acid
C03571 ,
nsc1019
alanine, 2-ethyl-
595-39-1
AKOS000186769
465-58-7
STK893542
2-amino-2-methylbutanoic acid
EN300-65927
jul973t11c ,
dl-isovaline
unii-jul973t11c
isovaline, dl-
A820450 ,
2-amino-2-methyl-butanoic acid
A827082
FT-0632475
FT-0632172
FT-0634626
FT-0632476
dl-.alpha.-amino-.alpha.-methylbutyric acid
dl-.alpha.-ethylalanine
dl-2-amino-2-methylbutyric acid
isovaline [mi]
BBL020852
AKOS016053554
SCHEMBL23348
mfcd00272968
methyl-aminoisobutyric acid
AM85837
2-azaniumyl-2-methyl-butanoate
2-ammonio-2-methylbutanoate
2-amino-2-methyl-butyric acid,rac
AS-60071
2-amino-2-methyl-butyric acid, rac
2-amino-2-methyl butyric acid
Q412994
SY074815
GCHPUFAZSONQIV-UHFFFAOYSA-N
methyl aminoisobutyric acid
(4-methoxybiphenyl-4-yl)-methanol
DTXSID70974906
CS-0311817
SY047556
Z317024736

Research Excerpts

Overview

Isovaline is a novel prototype analgesic. It produces peripheral antinociception in several pain models with little or no effect on the central nervous system.

ExcerptReferenceRelevance
"Isovaline is a novel prototype analgesic that produces peripheral antinociception in several pain models with little or no effect on the central nervous system."( Variations of isovaline structure related to activity in the formalin foot assay in mice.
Asiri, YI; Fung, T; MacLeod, BA; Puil, E; Schwarz, SKW; Wall, R, 2017
)
1.54
"Isovaline is a non-proteinogenic amino acid that has analgesic properties. "( Isovaline does not activate GABA(B) receptor-coupled potassium currents in GABA(B) expressing AtT-20 cells and cultured rat hippocampal neurons.
Borgland, SL; MacLeod, B; Pitman, KA; Puil, E, 2015
)
3.3
"R-isovaline is a non-proteinogenic amino acid which produces analgesia in a range of nociceptive assays. "( Differential effects of R-isovaline and the GABA
Asiri, YI; Asseri, KA; Fung, T; MacLeod, BA; Puil, E; Schwarz, SKW; Wall, RA, 2016
)
1.46

Toxicity

Isovaline at a maximal deliverable (soluble) dose of 5000 mg/kg produced no apparent respiratory depression or other adverse effects. We explored the possibility that isovaline may be an effective and safe alternative to opioids as an adjunct to propofol for producing anesthesia.

ExcerptReferenceRelevance
" Here, we explored the possibility that isovaline may be an effective and safe alternative to opioids as an adjunct to propofol for producing anesthesia."( The Efficacy and Safety of the Novel Peripheral Analgesic Isovaline as an Adjuvant to Propofol for General Anesthesia and Conscious Sedation: A Proof-of-Principle Study in Mice.
Asiri, YI; Fung, T; MacLeod, BA; Puil, E; Schwarz, SK; Whitehead, RA, 2015
)
0.93
" Isovaline at a maximal deliverable (soluble) dose of 5000 mg/kg produced no apparent respiratory depression or other adverse effects."( The Efficacy and Safety of the Novel Peripheral Analgesic Isovaline as an Adjuvant to Propofol for General Anesthesia and Conscious Sedation: A Proof-of-Principle Study in Mice.
Asiri, YI; Fung, T; MacLeod, BA; Puil, E; Schwarz, SK; Whitehead, RA, 2015
)
1.57
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (50)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (16.00)18.7374
1990's11 (22.00)18.2507
2000's7 (14.00)29.6817
2010's20 (40.00)24.3611
2020's4 (8.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.16

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.16 (24.57)
Research Supply Index3.97 (2.92)
Research Growth Index4.78 (4.65)
Search Engine Demand Index36.71 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.16)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (1.92%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other51 (98.08%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]