valproic acid has been researched along with Pain in 38 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Four patients had pancreatitis associated with valproic acid therapy." | 7.67 | Pancreatitis associated with valproic acid therapy. ( Cruse, RP; Erenberg, G; Rothner, AD; Wyllie, E; Wyllie, R, 1984) |
| " For treating trigeminal neuralgia, carbamazepine had a combined number needed to treat of 2." | 6.17 | Anticonvulsant drugs for management of pain: a systematic review. ( Carroll, D; Jadad, AR; McQuay, H; Moore, A; Wiffen, P, 1995) |
| "Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population." | 5.46 | sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017) |
| "This review was designated to evaluate the efficacy of parenteral ketorolac in treating acute migraine headache." | 5.22 | Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis. ( Abu Bakar, MA; Baharuddin, KA; Norhayati, MN; Nurathirah, MN; Yazid, MB, 2022) |
| " Examining antiepileptic prescribing to residents with ADRD who had disruptive behaviors and/or reported pain suggests that two of the most common antiepileptics, valproic acid and gabapentin, are being used in clinically distinct ways." | 4.31 | Antiepileptic prescribing to persons living with dementia residing in nursing homes: A tale of two indications. ( Candon, M; Gerlach, LB; Maust, DT; Strominger, J, 2023) |
| " The initial anticonvulsant screening was performed in mice (ip) using the 'classical' maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests as well as in the six-Hertz (6Hz) model of pharmacoresistant limbic seizures." | 3.83 | New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones. ( Abram, M; Andres-Mach, M; Kamiński, K; Obniska, J; Rapacz, A; Zagaja, M; Łuszczki, JJ, 2016) |
| " A number of VPA analogues and their amide, N-methylamide and urea derivatives, were synthesized and evaluated in animal models of neuropathic pain and epilepsy." | 3.75 | Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues. ( Bialer, M; Devor, M; Kaufmann, D; Shimshoni, JA; Yagen, B, 2009) |
| "Four patients had pancreatitis associated with valproic acid therapy." | 3.67 | Pancreatitis associated with valproic acid therapy. ( Cruse, RP; Erenberg, G; Rothner, AD; Wyllie, E; Wyllie, R, 1984) |
| "Valproic acid is used in first case as an antiepileptic; own clinical observance and references from the literature show other indication-fields outside of the group of cerebral fits; so Convulex was employed successfully also in the therapy of perioral dyskinesia of variable etiology and in the medical treatment of therapy-resistant pains within the bounds of Polyneuropathy-Polyneuritis Syndrome." | 3.67 | [Further therapeutic possibilities with valproic acid (Convulex)]. ( Auff, E; Holzner, F; Wessely, P, 1985) |
| "Migraine is a common primary headache disorder diagnosed in the emergency department (ED)." | 2.82 | Sodium Valproate Versus Dopamine Antagonists for Acute Migraine in the Emergency Department: A Systematic Review. ( Cheng, W; Cortel-LeBlanc, M; Nath, A; Patel, D; Perry, JJ; Viau, JA, 2022) |
| "Thirty-six patients established on migraine prophylaxis were administered 500 mg sodium valproate intravenously against acute migraine attacks." | 2.73 | Safety and efficacy of intravenous sodium valproate in the treatment of acute migraine. ( Marková, J; Mastík, J; Waberzinek, G, 2007) |
| "Pain was assessed using a pain scale based on the Brief Pain Inventory at days 0, 8 and 15." | 2.70 | A phase II study to establish the efficacy and toxicity of sodium valproate in patients with cancer-related neuropathic pain. ( A'Hern, R; Broadley, K; Gwilliam, B; Hardy, JR; Ling, J; Rees, EA, 2001) |
| "Chronic central pain is a frequent complication after spinal cord injury." | 2.67 | Valproate for treatment of chronic central pain after spinal cord injury. A double-blind cross-over study. ( Andreasen, A; Drewes, AM; Poulsen, LH, 1994) |
| "Comorbid diagnosis of headache predicted use of topiramate and VPA, bipolar disease predicted use of LMT and VPA, pain predicted gabapentin, and schizophrenia was associated with VPAs use." | 1.91 | Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy. ( Amuan, ME; Henion, A; Lopez, MR; Panahi, S; Pugh, MJ; VanCott, AC, 2023) |
| "Lamotrigine was the most frequently initiated drug in psychiatry, in both boys and girls." | 1.48 | Utilization of Antiepileptic Medicines in Swedish Children and Adolescents with Different Diagnoses. ( Karlsson Lind, L; von Euler, M; Wettermark, B; Wide, K, 2018) |
| "Chronic pain is a multifactorial disease comprised of both inflammatory and neuropathic components that affect ∼20% of the world's population." | 1.46 | sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain. ( Bialer, M; Brennan, KC; Devor, M; Kaufmann, D; Smith, MD; West, PJ; White, HS; Yagen, B, 2017) |
| "Idiopathic stabbing headache is a primary headache defined as "transient stabs of pain in the head that occur spontaneously in the absence of underlying organic disease." | 1.40 | Pediatric-onset extracephalic stabbing pain. ( Hino-Fukuyo, N; Kakisaka, Y; Kano, S; Kure, S; Uematsu, M, 2014) |
| "Valproic acid (VA) is a major antiepileptic drug, used for several therapeutic indications." | 1.39 | Valproic acid: an anticonvulsant drug with potent antinociceptive and anti-inflammatory properties. ( Correia, AO; da Graça Naffah-Mazzacorati, M; de Castro Brito, GA; de Oliveira Gonçalves, D; Félix, FH; Leal, LK; Neves, KR; Santos Cerqueira, G; Siqueira, RM; Viana, GS; Ximenes, JC, 2013) |
| " Comparative pharmacokinetic analysis showed that α-Cl-TMCD is less susceptible to liver first-pass effect than α-F-TMCD because of lower total (metabolic) clearance and liver extraction ratio." | 1.36 | Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid. ( Bialer, M; Finnell, RH; Hen, N; Kaufmann, D; Pessah, N; Wlodarczyk, B; Yagen, B, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (18.42) | 18.7374 |
| 1990's | 4 (10.53) | 18.2507 |
| 2000's | 11 (28.95) | 29.6817 |
| 2010's | 9 (23.68) | 24.3611 |
| 2020's | 7 (18.42) | 2.80 |
| Authors | Studies |
|---|---|
| Kaufmann, D | 3 |
| Bialer, M | 5 |
| Shimshoni, JA | 1 |
| Devor, M | 4 |
| Yagen, B | 5 |
| Kamiński, K | 2 |
| Zagaja, M | 1 |
| Rapacz, A | 2 |
| Łuszczki, JJ | 1 |
| Andres-Mach, M | 1 |
| Abram, M | 2 |
| Obniska, J | 2 |
| Nurathirah, MN | 1 |
| Yazid, MB | 1 |
| Norhayati, MN | 1 |
| Baharuddin, KA | 1 |
| Abu Bakar, MA | 1 |
| Günay, Ç | 1 |
| Edem, P | 1 |
| Hız-Kurul, AS | 1 |
| Yaşar, E | 1 |
| Yiş, U | 1 |
| Imado, E | 1 |
| Sun, S | 1 |
| Abawa, AR | 1 |
| Tahara, T | 1 |
| Kochi, T | 1 |
| Huynh, TNB | 1 |
| Asano, S | 1 |
| Hasebe, S | 1 |
| Nakamura, Y | 1 |
| Hisaoka-Nakashima, K | 1 |
| Kotake, Y | 1 |
| Irifune, M | 1 |
| Tsuga, K | 1 |
| Takuma, K | 1 |
| Morioka, N | 1 |
| Kiguchi, N | 1 |
| Ago, Y | 1 |
| Candon, M | 1 |
| Strominger, J | 1 |
| Gerlach, LB | 1 |
| Maust, DT | 1 |
| Lopez, MR | 1 |
| VanCott, AC | 1 |
| Amuan, ME | 1 |
| Panahi, S | 1 |
| Henion, A | 1 |
| Pugh, MJ | 1 |
| Góra, M | 1 |
| Sałat, K | 1 |
| Rybka, S | 1 |
| Jakubiec, M | 1 |
| Viau, JA | 1 |
| Patel, D | 1 |
| Cheng, W | 1 |
| Cortel-LeBlanc, M | 1 |
| Nath, A | 1 |
| Perry, JJ | 1 |
| Karlsson Lind, L | 1 |
| Wide, K | 1 |
| Wettermark, B | 1 |
| von Euler, M | 1 |
| Ximenes, JC | 1 |
| de Oliveira Gonçalves, D | 1 |
| Siqueira, RM | 1 |
| Neves, KR | 1 |
| Santos Cerqueira, G | 1 |
| Correia, AO | 1 |
| Félix, FH | 1 |
| Leal, LK | 1 |
| de Castro Brito, GA | 1 |
| da Graça Naffah-Mazzacorati, M | 1 |
| Viana, GS | 1 |
| Kakisaka, Y | 1 |
| Kano, S | 1 |
| Hino-Fukuyo, N | 1 |
| Uematsu, M | 1 |
| Kure, S | 1 |
| Barragan-Martinez, D | 1 |
| Urbanos-Nunez, A | 1 |
| Martinez-Salio, A | 1 |
| West, PJ | 1 |
| Smith, MD | 1 |
| White, HS | 1 |
| Brennan, KC | 1 |
| Agrawal, RP | 1 |
| Goswami, J | 1 |
| Jain, S | 1 |
| Kochar, DK | 2 |
| Pessah, N | 1 |
| Hen, N | 1 |
| Wlodarczyk, B | 1 |
| Finnell, RH | 1 |
| El-Azab, MF | 1 |
| Moustafa, YM | 1 |
| Coulter, DW | 1 |
| Walko, C | 1 |
| Patel, J | 1 |
| Moats-Staats, BM | 1 |
| McFadden, A | 1 |
| Smith, SV | 1 |
| Khan, WA | 1 |
| Bridges, AS | 1 |
| Deal, AM | 1 |
| Oesterheld, J | 1 |
| Davis, IJ | 1 |
| Blatt, J | 1 |
| Jain, N | 1 |
| Agarwal, RP | 1 |
| Srivastava, T | 1 |
| Agarwal, P | 1 |
| Gupta, S | 1 |
| Schneider, T | 1 |
| Turczak, J | 1 |
| Przewłocki, R | 1 |
| Winkler, I | 2 |
| Blotnik, S | 1 |
| Shimshoni, J | 1 |
| Sobol, E | 1 |
| Steinman, A | 1 |
| Waberzinek, G | 1 |
| Marková, J | 1 |
| Mastík, J | 1 |
| Savica, R | 1 |
| Beghi, E | 1 |
| Mazzaglia, G | 1 |
| Innocenti, F | 1 |
| Brignoli, O | 1 |
| Cricelli, C | 1 |
| Caputi, AP | 1 |
| Musolino, R | 1 |
| Spina, E | 1 |
| Trifirò, G | 1 |
| Wyllie, E | 1 |
| Wyllie, R | 1 |
| Cruse, RP | 1 |
| Erenberg, G | 1 |
| Rothner, AD | 1 |
| Swerdlow, M | 2 |
| Cundill, JG | 1 |
| McQuay, H | 1 |
| Carroll, D | 1 |
| Jadad, AR | 1 |
| Wiffen, P | 1 |
| Moore, A | 1 |
| Drewes, AM | 1 |
| Andreasen, A | 1 |
| Poulsen, LH | 1 |
| Zachariah, SB | 1 |
| Borges, EF | 1 |
| Varghese, R | 1 |
| Cruz, AR | 1 |
| Ross, GS | 1 |
| Anderson, GD | 1 |
| Lin, Y | 1 |
| Temkin, NR | 1 |
| Fischer, JH | 1 |
| Winn, HR | 1 |
| Hardy, JR | 1 |
| Rees, EA | 1 |
| Gwilliam, B | 1 |
| Ling, J | 1 |
| Broadley, K | 1 |
| A'Hern, R | 1 |
| Sinnott, C | 1 |
| Raftery, H | 1 |
| Frenk, H | 1 |
| Bossut, D | 1 |
| Mayer, DJ | 1 |
| Aley, KO | 1 |
| Kulkarni, SK | 1 |
| Auff, E | 1 |
| Holzner, F | 1 |
| Wessely, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Erenumab as a Therapeutic Approach for the Management of Trigeminal Neuropathic Pain (TNP)[NCT05142228] | Phase 2 | 5 participants (Actual) | Interventional | 2022-04-01 | Terminated (stopped due to Low enrollment rate) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for valproic acid and Pain
| Article | Year |
|---|---|
Efficacy of ketorolac in the treatment of acute migraine attack: A systematic review and meta-analysis.
Topics: Caffeine; Dexamethasone; Diclofenac; Humans; Ketorolac; Metoclopramide; Migraine Disorders; Pain; Ph | 2022 |
Sodium Valproate Versus Dopamine Antagonists for Acute Migraine in the Emergency Department: A Systematic Review.
Topics: Adult; Dopamine Antagonists; Emergency Service, Hospital; Humans; Migraine Disorders; Pain; Valproic | 2022 |
Anticonvulsant drugs for management of pain: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diabetic Neuropathies; Humans; Pain; Phenytoin; Treatmen | 1995 |
7 trials available for valproic acid and Pain
| Article | Year |
|---|---|
Management of diabetic neuropathy by sodium valproate and glyceryl trinitrate spray: a prospective double-blind randomized placebo-controlled study.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Diabetes Mellitus, Type 2; Diabetic Neuropathies; | 2009 |
Valproic acid reduces the tolerability of temsirolimus in children and adolescents with solid tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Diphenhydramine | 2013 |
Sodium valproate in the management of painful neuropathy in type 2 diabetes - a randomized placebo controlled study.
Topics: Adult; Aged; Anticonvulsants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Double-Blind Method; | 2002 |
Safety and efficacy of intravenous sodium valproate in the treatment of acute migraine.
Topics: Acute Disease; Adult; Anticonvulsants; Female; Humans; Injections, Intravenous; Middle Aged; Migrain | 2007 |
Anticonvulsant drugs for management of pain: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diabetic Neuropathies; Humans; Pain; Phenytoin; Treatmen | 1995 |
Valproate for treatment of chronic central pain after spinal cord injury. A double-blind cross-over study.
Topics: Adolescent; Adult; Aged; Chronic Disease; Cross-Over Studies; Double-Blind Method; Female; Humans; M | 1994 |
A phase II study to establish the efficacy and toxicity of sodium valproate in patients with cancer-related neuropathic pain.
Topics: Adult; Aged; Anticonvulsants; Female; Humans; Male; Middle Aged; Neoplasms; Nervous System Diseases; | 2001 |
29 other studies available for valproic acid and Pain
| Article | Year |
|---|---|
Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues.
Topics: Amides; Animals; Anticonvulsants; Electroshock; Isomerism; Male; Mice; Pain; Pentylenetetrazole; Rat | 2009 |
New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2016 |
Recurrent painful ophthalmoplegic neuropathy: a report of two new pediatric cases.
Topics: Child; Child, Preschool; Female; Headache; Humans; Magnetic Resonance Imaging; Ophthalmoplegia; Opht | 2022 |
Prenatal exposure to valproic acid causes allodynia associated with spinal microglial activation.
Topics: Animals; Autism Spectrum Disorder; Calcium; Disease Models, Animal; Female; Humans; Hyperalgesia; Ma | 2022 |
Antiepileptic prescribing to persons living with dementia residing in nursing homes: A tale of two indications.
Topics: Aged; Alzheimer Disease; Analgesics, Opioid; Anticonvulsants; Antipsychotic Agents; Gabapentin; Huma | 2023 |
Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Levetiracetam | 2023 |
Synthesis, anticonvulsant, and antinociceptive activity of new 3-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)propanamides and 3-phenyl-butanamides.
Topics: Amides; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Male; Mice; Pain | 2021 |
Utilization of Antiepileptic Medicines in Swedish Children and Adolescents with Different Diagnoses.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Prescriptions; Drug Utilization; Epilepsy | 2018 |
Valproic acid: an anticonvulsant drug with potent antinociceptive and anti-inflammatory properties.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Butyric Acid; Carrageenan; Drug Syne | 2013 |
Pediatric-onset extracephalic stabbing pain.
Topics: Child; Electroencephalography; Functional Laterality; GABA Agents; Headache Disorders, Primary; Huma | 2014 |
[Red ear syndrome: a case report with good therapeutic response].
Topics: Adult; Ear Auricle; Ear Diseases; Female; Humans; Pain; Recurrence; Remission Induction; Syndrome; V | 2015 |
sec-Butylpropylacetamide (SPD), a new amide derivative of valproic acid for the treatment of neuropathic and inflammatory pain.
Topics: Amides; Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Gabapentin | 2017 |
Comparative pharmacodynamic and pharmacokinetic analysis of two anticonvulsant halo derivatives of 2,2,3,3-tetramethylcyclopropanecarboxamide, an amide of a cyclic analog of valproic acid.
Topics: Abnormalities, Drug-Induced; Amides; Analgesics; Animals; Anticonvulsants; Cyclopropanes; Disease Mo | 2010 |
Influence of calcium channel blockers on anticonvulsant and antinociceptive activities of valproic acid in pentylenetetrazole-kindled mice.
Topics: Analgesics; Animals; Anticonvulsants; Calcium Channel Blockers; Disease Models, Animal; Drug Synergi | 2012 |
Environmental enrichment reverses behavioral alterations in rats prenatally exposed to valproic acid: issues for a therapeutic approach in autism.
Topics: Animals; Anticonvulsants; Anxiety; Autistic Disorder; Behavior, Animal; Environment; Exploratory Beh | 2006 |
Efficacy of antiepileptic isomers of valproic acid and valpromide in a rat model of neuropathic pain.
Topics: Analgesics; Animals; Anticonvulsants; Hyperalgesia; Isomerism; Ligation; Male; Pain; Pain Measuremen | 2005 |
Efficacy of antiepileptic tetramethylcyclopropyl analogues of valproic acid amides in a rat model of neuropathic pain.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Pain; Pain Measurement; Peripheral | 2005 |
Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005.
Topics: Adolescent; Adult; Age Distribution; Aged; Amines; Anticonvulsants; Carbamazepine; Catchment Area, H | 2007 |
Pancreatitis associated with valproic acid therapy.
Topics: Abdomen; Adolescent; Adult; Amylases; Blood Coagulation Disorders; Child; Child, Preschool; Female; | 1984 |
The treatment of "shooting" pain.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Female; Humans; Male; Middle Aged; Pain; Phenytoin; V | 1980 |
Anticonvulsant drugs used in the treatment of lancinating pain. A comparison.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Chronic Disease; Clonazepam; Female; Humans | 1981 |
Positive response to oral divalproex sodium (Depakote) in patients with spasticity and pain.
Topics: Adult; Humans; Male; Middle Aged; Muscle Spasticity; Pain; Valproic Acid | 1994 |
[Injectionable valproate: experiences in neurology pediatrics and psychiatry. Workshop at Hamburg, 8 November 1997].
Topics: Analgesics; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Child; Critical Care; Female; Human | 1998 |
Incidence of intravenous site reactions in neurotrauma patients receiving valproate or phenytoin.
Topics: Adult; Aged; Anticonvulsants; Brain Injuries; Chi-Square Distribution; Double-Blind Method; Female; | 2000 |
Problems recruiting cancer patients to a comparative clinical trial of drug treatments for neuropathic pain in palliative care.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Humans; Multicenter Studies as Topic; Neoplasms; Ne | 2002 |
The management of post herpetic pain using sodium valproate and amitriptyline.
Topics: Amitriptyline; Herpes Zoster; Humans; Pain; Valproic Acid | 1979 |
Is substance P a primary afferent neurotransmitter for nociceptive input? III. Valproic acid and chlordiazepoxide decrease behaviors elicited by intrathecal injection of substance P and excitatory compounds.
Topics: Animals; Anticonvulsants; Chlordiazepoxide; Injections, Spinal; Kainic Acid; Male; Morphine; Nocicep | 1988 |
GABAergic agents-induced antinociceptive effect in mice.
Topics: Analgesics; Animals; Baclofen; Bicuculline; Female; gamma-Aminobutyric Acid; Male; Mice; Morphine; M | 1989 |
[Further therapeutic possibilities with valproic acid (Convulex)].
Topics: Aged; Blepharospasm; Dyskinesia, Drug-Induced; Female; Foot Diseases; Humans; Male; Middle Aged; Myo | 1985 |