choline and Pain
choline has been researched along with Pain in 30 studies
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty-six patients with painful, bony metastases were recruited into a randomized, double-blind, single dose, two-treatment, three-part crossover study of choline magnesium trisalicylate (CMT) and placebo." | 9.07 | The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. ( Johnson, JR; Miller, AJ, 1994) |
| ") administered CDP-choline (cytidine-5'-diphosphate-choline; citicoline) and its metabolites in rat models of inflammatory and neuropathic pain." | 7.77 | The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models. ( Bagdas, D; Gurun, MS; Hamurtekin, E; Sonal, S; Sonat, FA, 2011) |
| " The results showed that AVP elevated the concentrations of leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek) and beta-endorphin (beta-Ep), but did not change the concentrations of dynorphinA(1-13) (DynA(1-13)), OXT, classical neurotransmitters including achetylcholine (Ach), choline (Ch), serotonin (5-HT), gamma-aminobutyric acid (GABA), glutamate (Glu), dopamine (DA), norepinephrine (NE) and epinephrine (E), and their metabolic products in PAG perfusion liquid." | 7.74 | Arginine vasopressin induces periaqueductal gray release of enkephalin and endorphin relating to pain modulation in the rat. ( Chen, JM; Lin, BC; Liu, WY; Xu, HT; Yang, J; Yang, Y, 2007) |
| "Intrathecal clonidine reduces tactile allodynia in animal models of neuropathic pain, and this effect is blocked by atropine." | 7.72 | Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. ( Conklin, D; Eisenach, JC; Paqueron, X, 2003) |
| "Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models." | 5.37 | Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011) |
| "When choline (2 mg/kg) was coadministered with aspirin (9." | 5.33 | Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005) |
| "Twenty-six patients with painful, bony metastases were recruited into a randomized, double-blind, single dose, two-treatment, three-part crossover study of choline magnesium trisalicylate (CMT) and placebo." | 5.07 | The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. ( Johnson, JR; Miller, AJ, 1994) |
| " Pain, depression, and emotional components of QOL in patients with CP correlated with N-acetyl aspartate and choline in the left hippocampus and left prefrontal cortex of the brain." | 4.12 | Pain, depression, and poor quality of life in chronic pancreatitis: Relationship with altered brain metabolites. ( Bedarkar, AP; Dhagudu, N; Hazarika, D; Jakkampudi, A; M, R; Pandol, SJ; Prasanna, A; Reddy, DN; Sarkar, P; Sarkar, S; Talukdar, R; Unnisa, M, 2022) |
| ") administered CDP-choline (cytidine-5'-diphosphate-choline; citicoline) and its metabolites in rat models of inflammatory and neuropathic pain." | 3.77 | The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models. ( Bagdas, D; Gurun, MS; Hamurtekin, E; Sonal, S; Sonat, FA, 2011) |
| " The results showed that (1) in the NRM perfuse liquid, pain stimulation could increase the concentrations of AVP, leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek), beta-endorphin (beta-Ep), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA), but not change the concentrations of dynorphinA(1-13) (DynA(1-13)), oxytocin, achetylcholine, choline, gamma-aminobutyric acid, glutamate, dopamine, 3,4-dihydroxyphenylacetic acid, homovanilic acid, norepinephrine and epinephrine; (2) in the NRM perfuse liquid, AVP increased the concentrations of L-Ek, M-Ek, beta-Ep, DynA(1-13), 5-HT and 5-HIAA, but did not change the concentrations of oxytocin and the other studied neurotransmitters; (3) AVP antinociception in the NRM was attenuated by cypoheptadine (a 5-HT-receptor antagonist) or naloxone (an opiate receptor antagonist), but was not influenced by the other studied receptor antagonists." | 3.75 | Arginine vasopressin antinociception in the rat nucleus raphe magnus is involved in the endogenous opiate peptide and serotonin system. ( Chu, J; Lin, BC; Liu, WY; Wang, G; Xu, H; Yang, J; Yang, Y; Yuan, H, 2009) |
| " The results showed that AVP elevated the concentrations of leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek) and beta-endorphin (beta-Ep), but did not change the concentrations of dynorphinA(1-13) (DynA(1-13)), OXT, classical neurotransmitters including achetylcholine (Ach), choline (Ch), serotonin (5-HT), gamma-aminobutyric acid (GABA), glutamate (Glu), dopamine (DA), norepinephrine (NE) and epinephrine (E), and their metabolic products in PAG perfusion liquid." | 3.74 | Arginine vasopressin induces periaqueductal gray release of enkephalin and endorphin relating to pain modulation in the rat. ( Chen, JM; Lin, BC; Liu, WY; Xu, HT; Yang, J; Yang, Y, 2007) |
| "Intrathecal clonidine reduces tactile allodynia in animal models of neuropathic pain, and this effect is blocked by atropine." | 3.72 | Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. ( Conklin, D; Eisenach, JC; Paqueron, X, 2003) |
| "Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models." | 1.37 | Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011) |
| "When choline (2 mg/kg) was coadministered with aspirin (9." | 1.33 | Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005) |
Research
Studies (30)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (40.00) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 8 (26.67) | 29.6817 |
| 2010's | 6 (20.00) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Sarkar, S | 1 |
| Sarkar, P | 1 |
| M, R | 1 |
| Hazarika, D | 1 |
| Prasanna, A | 1 |
| Pandol, SJ | 1 |
| Unnisa, M | 1 |
| Jakkampudi, A | 1 |
| Bedarkar, AP | 1 |
| Dhagudu, N | 1 |
| Reddy, DN | 1 |
| Talukdar, R | 1 |
| Sun, Y | 1 |
| Liang, D | 1 |
| Sahbaie, P | 1 |
| Clark, JD | 1 |
| Matias, M | 1 |
| Silvestre, S | 1 |
| Falcao, A | 1 |
| Alves, G | 1 |
| Yang, J | 2 |
| Yuan, H | 1 |
| Chu, J | 1 |
| Yang, Y | 2 |
| Xu, H | 1 |
| Wang, G | 1 |
| Liu, WY | 2 |
| Lin, BC | 2 |
| Gussew, A | 1 |
| Rzanny, R | 1 |
| Erdtel, M | 1 |
| Scholle, HC | 1 |
| Kaiser, WA | 1 |
| Mentzel, HJ | 1 |
| Reichenbach, JR | 1 |
| Williams, GD | 1 |
| Kirk, EP | 1 |
| Wilson, CJ | 1 |
| Meadows, CA | 1 |
| Chan, BS | 1 |
| Yong-Ping, S | 1 |
| Jin-Da, W | 1 |
| Ru-Huan, W | 1 |
| Xiang-Di, Z | 1 |
| Hai-Tao, Y | 1 |
| Hai, W | 1 |
| Bagdas, D | 1 |
| Sonat, FA | 1 |
| Hamurtekin, E | 1 |
| Sonal, S | 1 |
| Gurun, MS | 1 |
| Abe, K | 1 |
| Ishida, K | 1 |
| Kato, M | 1 |
| Shigenaga, T | 1 |
| Taguchi, K | 1 |
| Miyatake, T | 1 |
| Paqueron, X | 1 |
| Conklin, D | 1 |
| Eisenach, JC | 1 |
| HEREDIADIAZ, JG | 1 |
| SIERRA, E | 1 |
| Wang, Y | 1 |
| Su, DM | 1 |
| Wang, RH | 1 |
| Liu, Y | 1 |
| Wang, H | 1 |
| Xu, HT | 1 |
| Chen, JM | 1 |
| Sorensen, L | 1 |
| Siddall, PJ | 1 |
| Trenell, MI | 1 |
| Yue, DK | 1 |
| Romano, JA | 1 |
| Shih, TM | 1 |
| Sitaram, N | 1 |
| Gillin, JC | 1 |
| Johnson, JR | 1 |
| Miller, AJ | 1 |
| Yamamoto, M | 1 |
| Ooyama, M | 1 |
| Ozawa, Y | 1 |
| Okada, M | 1 |
| Tada, S | 1 |
| Yamaguchi, T | 1 |
| Endo, H | 1 |
| Romano, TJ | 1 |
| Damaj, MI | 1 |
| Meyer, EM | 1 |
| Martin, BR | 1 |
| Fernstrom, JD | 1 |
| Botticelli, LJ | 1 |
| Lytle, LD | 1 |
| Wurtman, RJ | 1 |
| Russell, RW | 1 |
| Booth, RA | 1 |
| Jenden, DJ | 1 |
| Chang, AS | 1 |
| Rice, KM | 1 |
| Roch, M | 1 |
| Lauretz, SD | 1 |
| Diamant, H | 1 |
| Jolley, HM | 1 |
| Torneck, CD | 1 |
| Siegel, I | 1 |
| Lawrence, N | 1 |
| Lum-Kam, G | 1 |
| Hewitt, HR | 1 |
| Gütz, HJ | 1 |
| Berndt, H | 1 |
| Wolff, G | 1 |
| Whalen, GE | 1 |
| Soergel, KH | 1 |
| Geenen, JE | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Pain Phenotypes in Chronic Pancreatitis and Identification of Clinical Surrogates of Pancreatic Neuropathy[NCT05713344] | 500 participants (Anticipated) | Observational | 2021-08-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
2 reviews available for choline and Pain
| Article | Year |
|---|---|
Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders.
Topics: Analgesics; Central Nervous System Diseases; Choline; Donepezil; Epilepsy; gamma-Aminobutyric Acid; | 2017 |
Effects on the diet on brain neurotransmitters.
Topics: Acetyl Coenzyme A; Acetylcholine; Animals; Brain; Catecholamines; Choline; Choline Deficiency; Diet; | 1977 |
Trials
3 trials available for choline and Pain
| Article | Year |
|---|---|
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Choline; Dose-Resp | 1994 |
A topical choline salicylate gel for control of pain and inflammation in oral conditions--a controlled study.
Topics: Adult; Aged; Choline; Clinical Trials as Topic; Dry Socket; Female; Gels; Humans; Male; Middle Aged; | 1972 |
A comparison of analgesic therapies for the relief of acute otalgia.
Topics: Acetaminophen; Choline; Clinical Trials as Topic; Ear Diseases; Humans; Pain; Salicylates | 1970 |
Other Studies
25 other studies available for choline and Pain
| Article | Year |
|---|---|
Pain, depression, and poor quality of life in chronic pancreatitis: Relationship with altered brain metabolites.
Topics: Brain; Choline; Depression; Humans; Pain; Pancreatitis, Chronic; Prospective Studies; Quality of Lif | 2022 |
Effects of methyl donor diets on incisional pain in mice.
Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Hindlimb; Hyperalgesia; Male; Methionine; | 2013 |
Arginine vasopressin antinociception in the rat nucleus raphe magnus is involved in the endogenous opiate peptide and serotonin system.
Topics: Analgesics; Animals; Arginine Vasopressin; Choline; Enkephalin, Leucine; Enkephalin, Methionine; gam | 2009 |
Time-resolved functional 1H MR spectroscopic detection of glutamate concentration changes in the brain during acute heat pain stimulation.
Topics: Acute Disease; Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Glutamic Acid; Hot Temperat | 2010 |
Salicylate intoxication from teething gel in infancy.
Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Choline; Drug Combinations; Female; Gels; Huma | 2011 |
Pharmacological action of choline and aspirin coadministration on acute inflammatory pain.
Topics: Acute Disease; Analgesics; Animals; Aspirin; Choline; Disease Models, Animal; Drug Combinations; Fem | 2011 |
The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Choline; Cytidine Diphosphate Choline; | 2011 |
Effect of morphine-induced antinociception is altered by AF64A-induced lesions on cholinergic neurons in rat nucleus raphe magnus.
Topics: Acetylcholine; Animals; Aziridines; Choline; Male; Morphine; Neuromuscular Blocking Agents; Neurons; | 2002 |
Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Analgesics; Animals; Atropine; Aziridines; Behavior, Anima | 2003 |
[EVALUATION OF A NEW SALICYLATE MOLECULE IN POST-IMMUNIZATION REACTIONS].
Topics: Adolescent; Child; Choline; Fever; Humans; Immune System Diseases; Immunization; Infant; Pain; Salic | 1963 |
Antinociceptive effects of choline against acute and inflammatory pain.
Topics: Aconitine; Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Anti-Inflamm | 2005 |
Arginine vasopressin induces periaqueductal gray release of enkephalin and endorphin relating to pain modulation in the rat.
Topics: Acetylcholine; Animals; Arginine Vasopressin; beta-Endorphin; Choline; Dopamine; Dose-Response Relat | 2007 |
Differences in metabolites in pain-processing brain regions in patients with diabetes and painful neuropathy.
Topics: Adult; Aged; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Diabetic Neuropathies; Female; | 2008 |
Cholinergic mechanisms of analgesia produced by physostigmine, morphine and cold water swimming.
Topics: Acetylcholine; Animals; Brain Chemistry; Choline; Cold Temperature; Male; Morphine; Pain; Parasympat | 1983 |
Development and use of pharmacological probes of the CNS in man: evidence of cholinergic abnormality in primary affective illness.
Topics: Acetylcholine; Arecoline; Central Nervous System; Choline; Disease Models, Animal; Dose-Response Rel | 1980 |
Effects of indeloxazine hydrochloride, a cerebral activator, on passive avoidance learning impaired by disruption of cholinergic transmission in rats.
Topics: Acetylcholine; Animals; Avoidance Learning; Aziridines; Basal Ganglia; Brain Chemistry; Choline; Dia | 1993 |
Medication for chronic pain in older persons.
Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Choline; Chronic Disease; Humans; Pain; | 2000 |
The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Benzylidene Compounds; Bungarotoxins; | 2000 |
Choline-induced attenuation of morphine analgesia in the rat.
Topics: Acetylcholine; Animals; Brain Chemistry; Choline; Dose-Response Relationship, Drug; Male; Morphine; | 1977 |
Incomplete reversibility of an experimentally induced hypocholinergic state: biochemical and physiological, but not behavioral, recovery.
Topics: Animals; Behavior, Animal; Body Temperature Regulation; Body Weight; Brain Chemistry; Choline; Choli | 1992 |
The investigation and management of non-neoplastic diseases affecting the salivary glands.
Topics: Choline; Citrates; Humans; Ligation; Microscopy, Electron; Mikulicz' Disease; Pain; Parotid Gland; P | 1974 |
Pain relief with a topical choline salicylate gel in dental practice.
Topics: Choline; Dry Socket; Female; Gingivitis; Humans; Male; Mouth Diseases; Ointments; Pain; Pericoroniti | 1969 |
Clinical evaluation of choline salicylate ear-drops.
Topics: Adolescent; Adult; Aspirin; Choline; Ear Diseases; Female; Humans; Male; Otitis Media; Pain; Salicyl | 1970 |
[Clinical trials in the therapy of peptic ulcer. 3. Ambulatary therapy of uncomplicated duodenal ulcer with diverse anticholinergic agents].
Topics: Antacids; Benzilates; Choline; Delayed-Action Preparations; Duodenal Ulcer; Gastric Juice; Heartburn | 1970 |
Diabetic diarrhea. A clinical and pathophysiological study.
Topics: Adult; Arteries; Biopsy; Blood Pressure; Choline; Diabetes Complications; Diabetes Mellitus; Diarrhe | 1969 |