Page last updated: 2024-10-16

choline and Pain

choline has been researched along with Pain in 30 studies

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Twenty-six patients with painful, bony metastases were recruited into a randomized, double-blind, single dose, two-treatment, three-part crossover study of choline magnesium trisalicylate (CMT) and placebo."9.07The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. ( Johnson, JR; Miller, AJ, 1994)
") administered CDP-choline (cytidine-5'-diphosphate-choline; citicoline) and its metabolites in rat models of inflammatory and neuropathic pain."7.77The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models. ( Bagdas, D; Gurun, MS; Hamurtekin, E; Sonal, S; Sonat, FA, 2011)
" The results showed that AVP elevated the concentrations of leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek) and beta-endorphin (beta-Ep), but did not change the concentrations of dynorphinA(1-13) (DynA(1-13)), OXT, classical neurotransmitters including achetylcholine (Ach), choline (Ch), serotonin (5-HT), gamma-aminobutyric acid (GABA), glutamate (Glu), dopamine (DA), norepinephrine (NE) and epinephrine (E), and their metabolic products in PAG perfusion liquid."7.74Arginine vasopressin induces periaqueductal gray release of enkephalin and endorphin relating to pain modulation in the rat. ( Chen, JM; Lin, BC; Liu, WY; Xu, HT; Yang, J; Yang, Y, 2007)
"Intrathecal clonidine reduces tactile allodynia in animal models of neuropathic pain, and this effect is blocked by atropine."7.72Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. ( Conklin, D; Eisenach, JC; Paqueron, X, 2003)
"Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models."5.37Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011)
"When choline (2 mg/kg) was coadministered with aspirin (9."5.33Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005)
"Twenty-six patients with painful, bony metastases were recruited into a randomized, double-blind, single dose, two-treatment, three-part crossover study of choline magnesium trisalicylate (CMT) and placebo."5.07The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. ( Johnson, JR; Miller, AJ, 1994)
" Pain, depression, and emotional components of QOL in patients with CP correlated with N-acetyl aspartate and choline in the left hippocampus and left prefrontal cortex of the brain."4.12Pain, depression, and poor quality of life in chronic pancreatitis: Relationship with altered brain metabolites. ( Bedarkar, AP; Dhagudu, N; Hazarika, D; Jakkampudi, A; M, R; Pandol, SJ; Prasanna, A; Reddy, DN; Sarkar, P; Sarkar, S; Talukdar, R; Unnisa, M, 2022)
") administered CDP-choline (cytidine-5'-diphosphate-choline; citicoline) and its metabolites in rat models of inflammatory and neuropathic pain."3.77The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models. ( Bagdas, D; Gurun, MS; Hamurtekin, E; Sonal, S; Sonat, FA, 2011)
" The results showed that (1) in the NRM perfuse liquid, pain stimulation could increase the concentrations of AVP, leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek), beta-endorphin (beta-Ep), serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA), but not change the concentrations of dynorphinA(1-13) (DynA(1-13)), oxytocin, achetylcholine, choline, gamma-aminobutyric acid, glutamate, dopamine, 3,4-dihydroxyphenylacetic acid, homovanilic acid, norepinephrine and epinephrine; (2) in the NRM perfuse liquid, AVP increased the concentrations of L-Ek, M-Ek, beta-Ep, DynA(1-13), 5-HT and 5-HIAA, but did not change the concentrations of oxytocin and the other studied neurotransmitters; (3) AVP antinociception in the NRM was attenuated by cypoheptadine (a 5-HT-receptor antagonist) or naloxone (an opiate receptor antagonist), but was not influenced by the other studied receptor antagonists."3.75Arginine vasopressin antinociception in the rat nucleus raphe magnus is involved in the endogenous opiate peptide and serotonin system. ( Chu, J; Lin, BC; Liu, WY; Wang, G; Xu, H; Yang, J; Yang, Y; Yuan, H, 2009)
" The results showed that AVP elevated the concentrations of leucine-enkephalin (L-Ek), methionine-enkephalin (M-Ek) and beta-endorphin (beta-Ep), but did not change the concentrations of dynorphinA(1-13) (DynA(1-13)), OXT, classical neurotransmitters including achetylcholine (Ach), choline (Ch), serotonin (5-HT), gamma-aminobutyric acid (GABA), glutamate (Glu), dopamine (DA), norepinephrine (NE) and epinephrine (E), and their metabolic products in PAG perfusion liquid."3.74Arginine vasopressin induces periaqueductal gray release of enkephalin and endorphin relating to pain modulation in the rat. ( Chen, JM; Lin, BC; Liu, WY; Xu, HT; Yang, J; Yang, Y, 2007)
"Intrathecal clonidine reduces tactile allodynia in animal models of neuropathic pain, and this effect is blocked by atropine."3.72Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury. ( Conklin, D; Eisenach, JC; Paqueron, X, 2003)
"Choline is a α7 nicotinic receptor agonist that has antinociceptive effects in a variety of pain models."1.37Pharmacological action of choline and aspirin coadministration on acute inflammatory pain. ( Hai, W; Hai-Tao, Y; Jin-Da, W; Ru-Huan, W; Xiang-Di, Z; Yong-Ping, S, 2011)
"When choline (2 mg/kg) was coadministered with aspirin (9."1.33Antinociceptive effects of choline against acute and inflammatory pain. ( Liu, Y; Su, DM; Wang, H; Wang, RH; Wang, Y, 2005)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199012 (40.00)18.7374
1990's3 (10.00)18.2507
2000's8 (26.67)29.6817
2010's6 (20.00)24.3611
2020's1 (3.33)2.80

Authors

AuthorsStudies
Sarkar, S1
Sarkar, P1
M, R1
Hazarika, D1
Prasanna, A1
Pandol, SJ1
Unnisa, M1
Jakkampudi, A1
Bedarkar, AP1
Dhagudu, N1
Reddy, DN1
Talukdar, R1
Sun, Y1
Liang, D1
Sahbaie, P1
Clark, JD1
Matias, M1
Silvestre, S1
Falcao, A1
Alves, G1
Yang, J2
Yuan, H1
Chu, J1
Yang, Y2
Xu, H1
Wang, G1
Liu, WY2
Lin, BC2
Gussew, A1
Rzanny, R1
Erdtel, M1
Scholle, HC1
Kaiser, WA1
Mentzel, HJ1
Reichenbach, JR1
Williams, GD1
Kirk, EP1
Wilson, CJ1
Meadows, CA1
Chan, BS1
Yong-Ping, S1
Jin-Da, W1
Ru-Huan, W1
Xiang-Di, Z1
Hai-Tao, Y1
Hai, W1
Bagdas, D1
Sonat, FA1
Hamurtekin, E1
Sonal, S1
Gurun, MS1
Abe, K1
Ishida, K1
Kato, M1
Shigenaga, T1
Taguchi, K1
Miyatake, T1
Paqueron, X1
Conklin, D1
Eisenach, JC1
HEREDIADIAZ, JG1
SIERRA, E1
Wang, Y1
Su, DM1
Wang, RH1
Liu, Y1
Wang, H1
Xu, HT1
Chen, JM1
Sorensen, L1
Siddall, PJ1
Trenell, MI1
Yue, DK1
Romano, JA1
Shih, TM1
Sitaram, N1
Gillin, JC1
Johnson, JR1
Miller, AJ1
Yamamoto, M1
Ooyama, M1
Ozawa, Y1
Okada, M1
Tada, S1
Yamaguchi, T1
Endo, H1
Romano, TJ1
Damaj, MI1
Meyer, EM1
Martin, BR1
Fernstrom, JD1
Botticelli, LJ1
Lytle, LD1
Wurtman, RJ1
Russell, RW1
Booth, RA1
Jenden, DJ1
Chang, AS1
Rice, KM1
Roch, M1
Lauretz, SD1
Diamant, H1
Jolley, HM1
Torneck, CD1
Siegel, I1
Lawrence, N1
Lum-Kam, G1
Hewitt, HR1
Gütz, HJ1
Berndt, H1
Wolff, G1
Whalen, GE1
Soergel, KH1
Geenen, JE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of Pain Phenotypes in Chronic Pancreatitis and Identification of Clinical Surrogates of Pancreatic Neuropathy[NCT05713344]500 participants (Anticipated)Observational2021-08-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for choline and Pain

ArticleYear
Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders.
    Mini reviews in medicinal chemistry, 2017, Volume: 17, Issue:6

    Topics: Analgesics; Central Nervous System Diseases; Choline; Donepezil; Epilepsy; gamma-Aminobutyric Acid;

2017
Effects on the diet on brain neurotransmitters.
    Metabolism: clinical and experimental, 1977, Volume: 26, Issue:2

    Topics: Acetyl Coenzyme A; Acetylcholine; Animals; Brain; Catecholamines; Choline; Choline Deficiency; Diet;

1977

Trials

3 trials available for choline and Pain

ArticleYear
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
    Palliative medicine, 1994, Volume: 8, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Choline; Dose-Resp

1994
A topical choline salicylate gel for control of pain and inflammation in oral conditions--a controlled study.
    Journal of the Canadian Dental Association, 1972, Volume: 38, Issue:2

    Topics: Adult; Aged; Choline; Clinical Trials as Topic; Dry Socket; Female; Gels; Humans; Male; Middle Aged;

1972
A comparison of analgesic therapies for the relief of acute otalgia.
    The British journal of clinical practice, 1970, Volume: 24, Issue:11

    Topics: Acetaminophen; Choline; Clinical Trials as Topic; Ear Diseases; Humans; Pain; Salicylates

1970

Other Studies

25 other studies available for choline and Pain

ArticleYear
Pain, depression, and poor quality of life in chronic pancreatitis: Relationship with altered brain metabolites.
    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2022, Volume: 22, Issue:6

    Topics: Brain; Choline; Depression; Humans; Pain; Pancreatitis, Chronic; Prospective Studies; Quality of Lif

2022
Effects of methyl donor diets on incisional pain in mice.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Animals; Choline; Dietary Supplements; Female; Folic Acid; Hindlimb; Hyperalgesia; Male; Methionine;

2013
Arginine vasopressin antinociception in the rat nucleus raphe magnus is involved in the endogenous opiate peptide and serotonin system.
    Peptides, 2009, Volume: 30, Issue:7

    Topics: Analgesics; Animals; Arginine Vasopressin; Choline; Enkephalin, Leucine; Enkephalin, Methionine; gam

2009
Time-resolved functional 1H MR spectroscopic detection of glutamate concentration changes in the brain during acute heat pain stimulation.
    NeuroImage, 2010, Jan-15, Volume: 49, Issue:2

    Topics: Acute Disease; Adult; Aspartic Acid; Cerebral Cortex; Choline; Creatine; Glutamic Acid; Hot Temperat

2010
Salicylate intoxication from teething gel in infancy.
    The Medical journal of Australia, 2011, Feb-07, Volume: 194, Issue:3

    Topics: Age Factors; Anti-Inflammatory Agents, Non-Steroidal; Choline; Drug Combinations; Female; Gels; Huma

2011
Pharmacological action of choline and aspirin coadministration on acute inflammatory pain.
    European journal of pain (London, England), 2011, Volume: 15, Issue:8

    Topics: Acute Disease; Analgesics; Animals; Aspirin; Choline; Disease Models, Animal; Drug Combinations; Fem

2011
The antihyperalgesic effect of cytidine-5'-diphosphate-choline in neuropathic and inflammatory pain models.
    Behavioural pharmacology, 2011, Volume: 22, Issue:5-6

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Choline; Cytidine Diphosphate Choline;

2011
Effect of morphine-induced antinociception is altered by AF64A-induced lesions on cholinergic neurons in rat nucleus raphe magnus.
    Acta pharmacologica Sinica, 2002, Volume: 23, Issue:11

    Topics: Acetylcholine; Animals; Aziridines; Choline; Male; Morphine; Neuromuscular Blocking Agents; Neurons;

2002
Plasticity in action of intrathecal clonidine to mechanical but not thermal nociception after peripheral nerve injury.
    Anesthesiology, 2003, Volume: 99, Issue:1

    Topics: Acetylcholine; Adrenergic alpha-Agonists; Analgesics; Animals; Atropine; Aziridines; Behavior, Anima

2003
[EVALUATION OF A NEW SALICYLATE MOLECULE IN POST-IMMUNIZATION REACTIONS].
    Medicina, 1963, Sep-10, Volume: 43

    Topics: Adolescent; Child; Choline; Fever; Humans; Immune System Diseases; Immunization; Infant; Pain; Salic

1963
Antinociceptive effects of choline against acute and inflammatory pain.
    Neuroscience, 2005, Volume: 132, Issue:1

    Topics: Aconitine; Acute Disease; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Anti-Inflamm

2005
Arginine vasopressin induces periaqueductal gray release of enkephalin and endorphin relating to pain modulation in the rat.
    Regulatory peptides, 2007, Jul-05, Volume: 142, Issue:1-2

    Topics: Acetylcholine; Animals; Arginine Vasopressin; beta-Endorphin; Choline; Dopamine; Dose-Response Relat

2007
Differences in metabolites in pain-processing brain regions in patients with diabetes and painful neuropathy.
    Diabetes care, 2008, Volume: 31, Issue:5

    Topics: Adult; Aged; Aspartic Acid; Brain; Brain Mapping; Choline; Creatine; Diabetic Neuropathies; Female;

2008
Cholinergic mechanisms of analgesia produced by physostigmine, morphine and cold water swimming.
    Neuropharmacology, 1983, Volume: 22, Issue:7

    Topics: Acetylcholine; Animals; Brain Chemistry; Choline; Cold Temperature; Male; Morphine; Pain; Parasympat

1983
Development and use of pharmacological probes of the CNS in man: evidence of cholinergic abnormality in primary affective illness.
    Biological psychiatry, 1980, Volume: 15, Issue:6

    Topics: Acetylcholine; Arecoline; Central Nervous System; Choline; Disease Models, Animal; Dose-Response Rel

1980
Effects of indeloxazine hydrochloride, a cerebral activator, on passive avoidance learning impaired by disruption of cholinergic transmission in rats.
    Neuropharmacology, 1993, Volume: 32, Issue:7

    Topics: Acetylcholine; Animals; Avoidance Learning; Aziridines; Basal Ganglia; Brain Chemistry; Choline; Dia

1993
Medication for chronic pain in older persons.
    Journal of the American Geriatrics Society, 2000, Volume: 48, Issue:1

    Topics: Age Factors; Aged; Anti-Inflammatory Agents, Non-Steroidal; Choline; Chronic Disease; Humans; Pain;

2000
The antinociceptive effects of alpha7 nicotinic agonists in an acute pain model.
    Neuropharmacology, 2000, Volume: 39, Issue:13

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Benzylidene Compounds; Bungarotoxins;

2000
Choline-induced attenuation of morphine analgesia in the rat.
    Communications in psychopharmacology, 1977, Volume: 1, Issue:6

    Topics: Acetylcholine; Animals; Brain Chemistry; Choline; Dose-Response Relationship, Drug; Male; Morphine;

1977
Incomplete reversibility of an experimentally induced hypocholinergic state: biochemical and physiological, but not behavioral, recovery.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:2

    Topics: Animals; Behavior, Animal; Body Temperature Regulation; Body Weight; Brain Chemistry; Choline; Choli

1992
The investigation and management of non-neoplastic diseases affecting the salivary glands.
    The Journal of laryngology and otology, 1974, Volume: 88, Issue:8

    Topics: Choline; Citrates; Humans; Ligation; Microscopy, Electron; Mikulicz' Disease; Pain; Parotid Gland; P

1974
Pain relief with a topical choline salicylate gel in dental practice.
    Journal of the Canadian Dental Association, 1969, Volume: 35, Issue:4

    Topics: Choline; Dry Socket; Female; Gingivitis; Humans; Male; Mouth Diseases; Ointments; Pain; Pericoroniti

1969
Clinical evaluation of choline salicylate ear-drops.
    The Practitioner, 1970, Volume: 204, Issue:221

    Topics: Adolescent; Adult; Aspirin; Choline; Ear Diseases; Female; Humans; Male; Otitis Media; Pain; Salicyl

1970
[Clinical trials in the therapy of peptic ulcer. 3. Ambulatary therapy of uncomplicated duodenal ulcer with diverse anticholinergic agents].
    Das Deutsche Gesundheitswesen, 1970, Mar-25, Volume: 25, Issue:12

    Topics: Antacids; Benzilates; Choline; Delayed-Action Preparations; Duodenal Ulcer; Gastric Juice; Heartburn

1970
Diabetic diarrhea. A clinical and pathophysiological study.
    Gastroenterology, 1969, Volume: 56, Issue:6

    Topics: Adult; Arteries; Biopsy; Blood Pressure; Choline; Diabetes Complications; Diabetes Mellitus; Diarrhe

1969