nortriptyline has been researched along with Pain in 30 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Excerpt | Relevance | Reference |
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" Adults with knee OA and a pain score of ≥20 points on the 50-point Western Ontario and McMaster University Osteoarthritis Index (WOMAC) pain subscale were randomised to receive either nortriptyline or identical placebo for 14 weeks." | 9.41 | Nortriptyline for pain in knee osteoarthritis: a double-blind randomised controlled trial in New Zealand general practice. ( Alchin, JS; Hooper, GJ; Hudson, B; Mangin, D; Stamp, LK; Thompson, BFL; Toop, L; Williman, JA, 2021) |
"The aim of this study was to evaluate the relative efficacy of nortriptyline and self-applied transcutaneous electrical nerve stimulation (TENS) in the treatment of pain and/or sensory complaints of the upper extremities in people with multiple sclerosis (MS)." | 9.14 | Sensory complaints of the upper extremities in multiple sclerosis: relative efficacy of nortriptyline and transcutaneous electrical nerve stimulation. ( Ashtari, F; Chitsaz, A; Freeman, J; Heshmatipour, M; Janghorbani, M; Shaygannejad, V, 2009) |
"The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks." | 9.06 | Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986) |
"The GABA amides of the antidepressants nortriptyline and fluoxetine, 1 and 2, were compared to their respective parent compounds in rodent models of pain." | 7.75 | Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity. ( Aharoni, A; Geffen, Y; Gil-Ad, I; Halbfinger, E; Nisemblat, Y; Nudelman, A; Rephaeli, A; Tarasenko, I; Tarasenko, N; Weizman, A, 2009) |
"Physicians caring for patients with CSPN should consider mexiletine to address pain and fatigue, although nortriptyline and duloxetine are better medications to trial first since they are better tolerated." | 5.51 | A secondary analysis of PAIN-CONTRoLS: Pain's impact on sleep, fatigue, and activities of daily living. ( Barohn, RJ; Bhai, SF; Brown, A; Gajewski, B; Kimminau, KS; Pasnoor, M; Waitman, LR, 2022) |
"Key messagesPeripheral lidocaine and oestradiol and centrally-targeted nortriptyline medications are used for the treatment of pain in women with VBD, but there is a lack of data from well-powered RCTs." | 5.51 | Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe). ( Akaninwor, J; Bortsov, A; Carey, ET; Cutting, H; DeLaRosa, J; Farb, D; Geller, EJ; Luo, S; McNulty, S; Merrill, P; Nackley, AG; Rapkin, A; Stirling, C; Zakroysky, P, 2022) |
" Adults with knee OA and a pain score of ≥20 points on the 50-point Western Ontario and McMaster University Osteoarthritis Index (WOMAC) pain subscale were randomised to receive either nortriptyline or identical placebo for 14 weeks." | 5.41 | Nortriptyline for pain in knee osteoarthritis: a double-blind randomised controlled trial in New Zealand general practice. ( Alchin, JS; Hooper, GJ; Hudson, B; Mangin, D; Stamp, LK; Thompson, BFL; Toop, L; Williman, JA, 2021) |
"The aim of this study was to evaluate the relative efficacy of nortriptyline and self-applied transcutaneous electrical nerve stimulation (TENS) in the treatment of pain and/or sensory complaints of the upper extremities in people with multiple sclerosis (MS)." | 5.14 | Sensory complaints of the upper extremities in multiple sclerosis: relative efficacy of nortriptyline and transcutaneous electrical nerve stimulation. ( Ashtari, F; Chitsaz, A; Freeman, J; Heshmatipour, M; Janghorbani, M; Shaygannejad, V, 2009) |
"The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks." | 5.06 | Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986) |
"A controlled clinical trial on the efficacy of a nortriptyline-fluphenazine combination was carried out in patients with painful diabetic polyneuropathy." | 5.05 | Nortriptyline and fluphenazine in the symptomatic treatment of diabetic neuropathy. A double-blind cross-over study. ( Dies, H; Gomez-Perez, FJ; Gonzalez-Barranco, J; Lozano-Castañeda, O; Rodriguez-Rivera, GJ; Rull, JA, 1985) |
"Urinary excretion data were obtained from 55,296 patients with pain and were analyzed using liquid chromatography tandem mass spectrometry in a multiplex assay which included amitriptyline, nortriptyline, and imipramine." | 3.80 | Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing. ( Atayee, RS; Best, BM; Bordson, SJ; Ma, JD, 2014) |
"The GABA amides of the antidepressants nortriptyline and fluoxetine, 1 and 2, were compared to their respective parent compounds in rodent models of pain." | 3.75 | Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity. ( Aharoni, A; Geffen, Y; Gil-Ad, I; Halbfinger, E; Nisemblat, Y; Nudelman, A; Rephaeli, A; Tarasenko, I; Tarasenko, N; Weizman, A, 2009) |
"Although this is a small study, it appears that gabapentin and nortriptyline are effective in the treatment of idiopathic chronic orchialgia but not post-vasectomy pain." | 3.74 | Chronic orchialgia: consider gabapentin or nortriptyline before considering surgery. ( Lee, LK; Miller, B; Sinclair, AM, 2007) |
"The pain is characterized by a burning or stinging sensation similar to neuropathic pain sensations." | 2.70 | Randomized trial of opioids versus tricyclic antidepressants for radiation-induced mucositis pain in head and neck cancer. ( Andersen, J; Ehrnrooth, E; Grau, C; Zachariae, R, 2001) |
"The responsiveness of both migraine headaches and carotidynia to similar drugs suggests a common pathophysiologic mechanism." | 1.26 | Carotidynia. ( Prusiner, S; Raskin, NH, 1977) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 10 (33.33) | 18.7374 |
1990's | 3 (10.00) | 18.2507 |
2000's | 9 (30.00) | 29.6817 |
2010's | 4 (13.33) | 24.3611 |
2020's | 4 (13.33) | 2.80 |
Authors | Studies |
---|---|
Rephaeli, A | 1 |
Gil-Ad, I | 1 |
Aharoni, A | 1 |
Tarasenko, I | 1 |
Tarasenko, N | 1 |
Geffen, Y | 1 |
Halbfinger, E | 1 |
Nisemblat, Y | 1 |
Weizman, A | 1 |
Nudelman, A | 1 |
Bhai, SF | 1 |
Brown, A | 1 |
Gajewski, B | 1 |
Kimminau, KS | 1 |
Waitman, LR | 1 |
Pasnoor, M | 1 |
Barohn, RJ | 1 |
Carey, ET | 1 |
Geller, EJ | 1 |
Rapkin, A | 1 |
Farb, D | 1 |
Cutting, H | 1 |
Akaninwor, J | 1 |
Stirling, C | 1 |
Bortsov, A | 1 |
McNulty, S | 1 |
Merrill, P | 1 |
Zakroysky, P | 1 |
DeLaRosa, J | 1 |
Luo, S | 1 |
Nackley, AG | 1 |
Makau, CM | 1 |
Towett, PK | 1 |
Kanui, TI | 1 |
Abelson, KSP | 1 |
Hudson, B | 1 |
Williman, JA | 1 |
Stamp, LK | 1 |
Alchin, JS | 1 |
Hooper, GJ | 1 |
Mangin, D | 1 |
Thompson, BFL | 1 |
Toop, L | 1 |
Jaracz, J | 1 |
Gattner, K | 1 |
Jaracz, K | 1 |
Górna, K | 1 |
Moczko, J | 1 |
Hauser, J | 1 |
Bordson, SJ | 1 |
Atayee, RS | 1 |
Ma, JD | 1 |
Best, BM | 1 |
Haviv, Y | 1 |
Zadik, Y | 1 |
Sharav, Y | 1 |
Benoliel, R | 1 |
Reed, BD | 1 |
Cantor, LE | 1 |
Chitsaz, A | 1 |
Janghorbani, M | 1 |
Shaygannejad, V | 1 |
Ashtari, F | 1 |
Heshmatipour, M | 1 |
Freeman, J | 1 |
Verstraelen, H | 1 |
Roelens, K | 1 |
De Knijf, A | 1 |
Temmerman, M | 1 |
Sudoh, Y | 1 |
Cahoon, EE | 1 |
Gerner, P | 1 |
Wang, GK | 1 |
Rosenlicht, NZ | 1 |
Riley-Lazo, KP | 1 |
Yi, BA | 1 |
Nirenberg, MJ | 1 |
Goldstein, SM | 1 |
Berger, TG | 1 |
Sinclair, AM | 1 |
Miller, B | 1 |
Lee, LK | 1 |
Gómez-Pérez, FJ | 2 |
Choza, R | 1 |
Ríos, JM | 1 |
Reza, A | 1 |
Huerta, E | 1 |
Aguilar, CA | 1 |
Rull, JA | 2 |
Cohen, H | 1 |
Cohen, MR | 1 |
Lofland, JH | 1 |
Szarlej, D | 1 |
Buttaro, T | 1 |
Shermock, S | 1 |
Jalali, S | 1 |
Ehrnrooth, E | 1 |
Grau, C | 1 |
Zachariae, R | 1 |
Andersen, J | 1 |
Raskin, NH | 1 |
Prusiner, S | 1 |
Panerai, AE | 1 |
Monza, G | 1 |
Movilia, P | 1 |
Bianchi, M | 1 |
Francucci, BM | 1 |
Tiengo, M | 1 |
Rascol, O | 1 |
Tran, MA | 1 |
Bonnevialle, P | 1 |
Belin, J | 1 |
Cotonat, J | 1 |
Guiraud-Chaumeil, B | 1 |
Montastruc, JL | 1 |
Testa, R | 1 |
Angelico, P | 1 |
Abbiati, GA | 1 |
Edelbroek, PM | 1 |
Linssen, AC | 1 |
Zitman, FG | 1 |
Rooymans, HG | 1 |
de Wolff, FA | 1 |
Dies, H | 1 |
Rodriguez-Rivera, GJ | 1 |
Gonzalez-Barranco, J | 1 |
Lozano-Castañeda, O | 1 |
Taub, A | 1 |
Saarnivaara, L | 1 |
Végh, J | 1 |
Kaeser, HE | 1 |
Opitz, K | 1 |
Borchert, U | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662] | Phase 4 | 50 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
10 trials available for nortriptyline and Pain
Article | Year |
---|---|
A secondary analysis of PAIN-CONTRoLS: Pain's impact on sleep, fatigue, and activities of daily living.
Topics: Activities of Daily Living; Bayes Theorem; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hy | 2022 |
Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe).
Topics: Antidepressive Agents, Tricyclic; Cytokines; Estradiol; Female; Humans; Lidocaine; MicroRNAs; Multic | 2022 |
Nortriptyline for pain in knee osteoarthritis: a double-blind randomised controlled trial in New Zealand general practice.
Topics: Adult; Double-Blind Method; General Practice; Humans; New Zealand; Nortriptyline; Osteoarthritis, Kn | 2021 |
Sensory complaints of the upper extremities in multiple sclerosis: relative efficacy of nortriptyline and transcutaneous electrical nerve stimulation.
Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Electric Stimulation Therapy; Female; Humans; M | 2009 |
Nortriptyline-fluphenazine vs. carbamazepine in the symptomatic treatment of diabetic neuropathy.
Topics: Adult; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Carbamazepine; Cross-Over Studies | 1996 |
Randomized trial of opioids versus tricyclic antidepressants for radiation-induced mucositis pain in head and neck cancer.
Topics: Aged; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Female; Head and Neck Neoplasms; Humans; | 2001 |
A randomized, within-patient, cross-over, placebo-controlled trial on the efficacy and tolerability of the tricyclic antidepressants chlorimipramine and nortriptyline in central pain.
Topics: Adult; Clomipramine; Double-Blind Method; Female; Humans; Male; Middle Aged; Nortriptyline; Pain; Pl | 1990 |
Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain.
Topics: Adult; Amitriptyline; Analgesics; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; | 1986 |
Nortriptyline and fluphenazine in the symptomatic treatment of diabetic neuropathy. A double-blind cross-over study.
Topics: Adult; Aged; Clinical Trials as Topic; Diabetic Neuropathies; Double-Blind Method; Female; Fluphenaz | 1985 |
[Clinical studies of a new analgesic in a double-blind trial].
Topics: Aminopyrine; Analgesics; Clinical Trials as Topic; Dextropropoxyphene; Humans; Nortriptyline; Pain; | 1970 |
20 other studies available for nortriptyline and Pain
Article | Year |
---|---|
Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity.
Topics: Analgesics; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Fluoxetine; Formaldehyde; gam | 2009 |
Antinociceptive effects of nortriptyline and desipramine hydrochloride in Speke's hinge-back tortoise (Kinixys Spekii).
Topics: Analgesics; Animals; Capsaicin; Desipramine; Formaldehyde; Nortriptyline; Pain; Turtles | 2023 |
Is Venlafaxine More Effective than Escitalopram and Nortriptyline in the Management of Painful Symptoms in Patients with Major Depression?
Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Female; Follow-Up Studies; Hum | 2018 |
Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing.
Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Interact | 2014 |
Painful traumatic trigeminal neuropathy: an open study on the pharmacotherapeutic response to stepped treatment.
Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Baclofen; Carbamazepine; Clinical Proto | 2014 |
Vulvodynia in preadolescent girls.
Topics: Antidepressive Agents, Tricyclic; Child; Child, Preschool; Chronic Disease; Female; Humans; Nortript | 2008 |
Persistent aching and itching of the clitoris.
Topics: Adrenergic Uptake Inhibitors; Adult; Clitoris; Female; Humans; Nortriptyline; Pain; Pruritus Vulvae; | 2013 |
Tricyclic antidepressants as long-acting local anesthetics.
Topics: Amines; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Cell Line; Dose-Response Rela | 2003 |
Interactions of cyclobenzaprine and tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Interactions; Humans; Mal | 2005 |
Chronic neuropathic pain associated with imiquimod: report of 2 cases.
Topics: Aminoquinolines; Antiviral Agents; Chronic Disease; Female; Humans; Imiquimod; Male; Middle Aged; No | 2005 |
Chronic orchialgia: consider gabapentin or nortriptyline before considering surgery.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Amines; Calcium Channel Blockers; Chronic Disease; Cycloh | 2007 |
Nortriptyline and neuropathic pain.
Topics: Antidepressive Agents, Tricyclic; Diabetic Neuropathies; Humans; Medication Errors; Nortriptyline; P | 1999 |
Cyclobenzaprine hydrochloride is a commonly prescribed centrally acting muscle relaxant, which is structurally similar to tricyclic antidepressants (TCAs) and differs from amitriptyline by only one double bond.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Drug Therapy, Combination; | 2001 |
Carotidynia.
Topics: Adult; Aged; Carotid Artery Diseases; Dose-Response Relationship, Drug; Ergonovine; Female; Headache | 1977 |
Lack of correlation between plasma levels of amitriptyline (and nortriptyline) and clinical improvement of chronic pain of peripheral neurologic origin.
Topics: Adult; Aged; Amitriptyline; Analgesics; Female; Humans; Male; Middle Aged; Nortriptyline; Pain; Pain | 1987 |
Effect of citalopram, amineptine, imipramine and nortriptyline on stress-induced (footshock) analgesia in rats.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Dibenzocycloheptenes; | 1987 |
Relief of postherpetic neuralgia with psychotropic drugs.
Topics: Aged; Amitriptyline; Analgesics; Antidepressive Agents; Antipsychotic Agents; Female; Fluphenazine; | 1973 |
Analgesic activity of some sympathetic drugs and their effect on morphine analgesia in rabbits.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A | 1969 |
[Therapy of polyneuritides].
Topics: Butyrophenones; Chlorpromazine; Glucocorticoids; Humans; Hypoxia; Imipramine; Methotrimeprazine; Nor | 1971 |
[On the management of pain using antidepressive agents].
Topics: Amitriptyline; Antidepressive Agents; Desipramine; Humans; Imipramine; Nortriptyline; Pain | 1967 |