nortriptyline has been researched along with Pain in 30 studies
Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Adults with knee OA and a pain score of ≥20 points on the 50-point Western Ontario and McMaster University Osteoarthritis Index (WOMAC) pain subscale were randomised to receive either nortriptyline or identical placebo for 14 weeks." | 9.41 | Nortriptyline for pain in knee osteoarthritis: a double-blind randomised controlled trial in New Zealand general practice. ( Alchin, JS; Hooper, GJ; Hudson, B; Mangin, D; Stamp, LK; Thompson, BFL; Toop, L; Williman, JA, 2021) |
| "The aim of this study was to evaluate the relative efficacy of nortriptyline and self-applied transcutaneous electrical nerve stimulation (TENS) in the treatment of pain and/or sensory complaints of the upper extremities in people with multiple sclerosis (MS)." | 9.14 | Sensory complaints of the upper extremities in multiple sclerosis: relative efficacy of nortriptyline and transcutaneous electrical nerve stimulation. ( Ashtari, F; Chitsaz, A; Freeman, J; Heshmatipour, M; Janghorbani, M; Shaygannejad, V, 2009) |
| "The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks." | 9.06 | Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986) |
| "The GABA amides of the antidepressants nortriptyline and fluoxetine, 1 and 2, were compared to their respective parent compounds in rodent models of pain." | 7.75 | Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity. ( Aharoni, A; Geffen, Y; Gil-Ad, I; Halbfinger, E; Nisemblat, Y; Nudelman, A; Rephaeli, A; Tarasenko, I; Tarasenko, N; Weizman, A, 2009) |
| "Physicians caring for patients with CSPN should consider mexiletine to address pain and fatigue, although nortriptyline and duloxetine are better medications to trial first since they are better tolerated." | 5.51 | A secondary analysis of PAIN-CONTRoLS: Pain's impact on sleep, fatigue, and activities of daily living. ( Barohn, RJ; Bhai, SF; Brown, A; Gajewski, B; Kimminau, KS; Pasnoor, M; Waitman, LR, 2022) |
| "Key messagesPeripheral lidocaine and oestradiol and centrally-targeted nortriptyline medications are used for the treatment of pain in women with VBD, but there is a lack of data from well-powered RCTs." | 5.51 | Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe). ( Akaninwor, J; Bortsov, A; Carey, ET; Cutting, H; DeLaRosa, J; Farb, D; Geller, EJ; Luo, S; McNulty, S; Merrill, P; Nackley, AG; Rapkin, A; Stirling, C; Zakroysky, P, 2022) |
| " Adults with knee OA and a pain score of ≥20 points on the 50-point Western Ontario and McMaster University Osteoarthritis Index (WOMAC) pain subscale were randomised to receive either nortriptyline or identical placebo for 14 weeks." | 5.41 | Nortriptyline for pain in knee osteoarthritis: a double-blind randomised controlled trial in New Zealand general practice. ( Alchin, JS; Hooper, GJ; Hudson, B; Mangin, D; Stamp, LK; Thompson, BFL; Toop, L; Williman, JA, 2021) |
| "The aim of this study was to evaluate the relative efficacy of nortriptyline and self-applied transcutaneous electrical nerve stimulation (TENS) in the treatment of pain and/or sensory complaints of the upper extremities in people with multiple sclerosis (MS)." | 5.14 | Sensory complaints of the upper extremities in multiple sclerosis: relative efficacy of nortriptyline and transcutaneous electrical nerve stimulation. ( Ashtari, F; Chitsaz, A; Freeman, J; Heshmatipour, M; Janghorbani, M; Shaygannejad, V, 2009) |
| "The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks." | 5.06 | Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986) |
| "A controlled clinical trial on the efficacy of a nortriptyline-fluphenazine combination was carried out in patients with painful diabetic polyneuropathy." | 5.05 | Nortriptyline and fluphenazine in the symptomatic treatment of diabetic neuropathy. A double-blind cross-over study. ( Dies, H; Gomez-Perez, FJ; Gonzalez-Barranco, J; Lozano-Castañeda, O; Rodriguez-Rivera, GJ; Rull, JA, 1985) |
| "Urinary excretion data were obtained from 55,296 patients with pain and were analyzed using liquid chromatography tandem mass spectrometry in a multiplex assay which included amitriptyline, nortriptyline, and imipramine." | 3.80 | Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing. ( Atayee, RS; Best, BM; Bordson, SJ; Ma, JD, 2014) |
| "The GABA amides of the antidepressants nortriptyline and fluoxetine, 1 and 2, were compared to their respective parent compounds in rodent models of pain." | 3.75 | Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity. ( Aharoni, A; Geffen, Y; Gil-Ad, I; Halbfinger, E; Nisemblat, Y; Nudelman, A; Rephaeli, A; Tarasenko, I; Tarasenko, N; Weizman, A, 2009) |
| "Although this is a small study, it appears that gabapentin and nortriptyline are effective in the treatment of idiopathic chronic orchialgia but not post-vasectomy pain." | 3.74 | Chronic orchialgia: consider gabapentin or nortriptyline before considering surgery. ( Lee, LK; Miller, B; Sinclair, AM, 2007) |
| "The pain is characterized by a burning or stinging sensation similar to neuropathic pain sensations." | 2.70 | Randomized trial of opioids versus tricyclic antidepressants for radiation-induced mucositis pain in head and neck cancer. ( Andersen, J; Ehrnrooth, E; Grau, C; Zachariae, R, 2001) |
| "The responsiveness of both migraine headaches and carotidynia to similar drugs suggests a common pathophysiologic mechanism." | 1.26 | Carotidynia. ( Prusiner, S; Raskin, NH, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (33.33) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 9 (30.00) | 29.6817 |
| 2010's | 4 (13.33) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Rephaeli, A | 1 |
| Gil-Ad, I | 1 |
| Aharoni, A | 1 |
| Tarasenko, I | 1 |
| Tarasenko, N | 1 |
| Geffen, Y | 1 |
| Halbfinger, E | 1 |
| Nisemblat, Y | 1 |
| Weizman, A | 1 |
| Nudelman, A | 1 |
| Bhai, SF | 1 |
| Brown, A | 1 |
| Gajewski, B | 1 |
| Kimminau, KS | 1 |
| Waitman, LR | 1 |
| Pasnoor, M | 1 |
| Barohn, RJ | 1 |
| Carey, ET | 1 |
| Geller, EJ | 1 |
| Rapkin, A | 1 |
| Farb, D | 1 |
| Cutting, H | 1 |
| Akaninwor, J | 1 |
| Stirling, C | 1 |
| Bortsov, A | 1 |
| McNulty, S | 1 |
| Merrill, P | 1 |
| Zakroysky, P | 1 |
| DeLaRosa, J | 1 |
| Luo, S | 1 |
| Nackley, AG | 1 |
| Makau, CM | 1 |
| Towett, PK | 1 |
| Kanui, TI | 1 |
| Abelson, KSP | 1 |
| Hudson, B | 1 |
| Williman, JA | 1 |
| Stamp, LK | 1 |
| Alchin, JS | 1 |
| Hooper, GJ | 1 |
| Mangin, D | 1 |
| Thompson, BFL | 1 |
| Toop, L | 1 |
| Jaracz, J | 1 |
| Gattner, K | 1 |
| Jaracz, K | 1 |
| Górna, K | 1 |
| Moczko, J | 1 |
| Hauser, J | 1 |
| Bordson, SJ | 1 |
| Atayee, RS | 1 |
| Ma, JD | 1 |
| Best, BM | 1 |
| Haviv, Y | 1 |
| Zadik, Y | 1 |
| Sharav, Y | 1 |
| Benoliel, R | 1 |
| Reed, BD | 1 |
| Cantor, LE | 1 |
| Chitsaz, A | 1 |
| Janghorbani, M | 1 |
| Shaygannejad, V | 1 |
| Ashtari, F | 1 |
| Heshmatipour, M | 1 |
| Freeman, J | 1 |
| Verstraelen, H | 1 |
| Roelens, K | 1 |
| De Knijf, A | 1 |
| Temmerman, M | 1 |
| Sudoh, Y | 1 |
| Cahoon, EE | 1 |
| Gerner, P | 1 |
| Wang, GK | 1 |
| Rosenlicht, NZ | 1 |
| Riley-Lazo, KP | 1 |
| Yi, BA | 1 |
| Nirenberg, MJ | 1 |
| Goldstein, SM | 1 |
| Berger, TG | 1 |
| Sinclair, AM | 1 |
| Miller, B | 1 |
| Lee, LK | 1 |
| Gómez-Pérez, FJ | 2 |
| Choza, R | 1 |
| Ríos, JM | 1 |
| Reza, A | 1 |
| Huerta, E | 1 |
| Aguilar, CA | 1 |
| Rull, JA | 2 |
| Cohen, H | 1 |
| Cohen, MR | 1 |
| Lofland, JH | 1 |
| Szarlej, D | 1 |
| Buttaro, T | 1 |
| Shermock, S | 1 |
| Jalali, S | 1 |
| Ehrnrooth, E | 1 |
| Grau, C | 1 |
| Zachariae, R | 1 |
| Andersen, J | 1 |
| Raskin, NH | 1 |
| Prusiner, S | 1 |
| Panerai, AE | 1 |
| Monza, G | 1 |
| Movilia, P | 1 |
| Bianchi, M | 1 |
| Francucci, BM | 1 |
| Tiengo, M | 1 |
| Rascol, O | 1 |
| Tran, MA | 1 |
| Bonnevialle, P | 1 |
| Belin, J | 1 |
| Cotonat, J | 1 |
| Guiraud-Chaumeil, B | 1 |
| Montastruc, JL | 1 |
| Testa, R | 1 |
| Angelico, P | 1 |
| Abbiati, GA | 1 |
| Edelbroek, PM | 1 |
| Linssen, AC | 1 |
| Zitman, FG | 1 |
| Rooymans, HG | 1 |
| de Wolff, FA | 1 |
| Dies, H | 1 |
| Rodriguez-Rivera, GJ | 1 |
| Gonzalez-Barranco, J | 1 |
| Lozano-Castañeda, O | 1 |
| Taub, A | 1 |
| Saarnivaara, L | 1 |
| Végh, J | 1 |
| Kaeser, HE | 1 |
| Opitz, K | 1 |
| Borchert, U | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662] | Phase 4 | 50 participants (Anticipated) | Interventional | 2015-02-28 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
10 trials available for nortriptyline and Pain
| Article | Year |
|---|---|
A secondary analysis of PAIN-CONTRoLS: Pain's impact on sleep, fatigue, and activities of daily living.
Topics: Activities of Daily Living; Bayes Theorem; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hy | 2022 |
Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe).
Topics: Antidepressive Agents, Tricyclic; Cytokines; Estradiol; Female; Humans; Lidocaine; MicroRNAs; Multic | 2022 |
Nortriptyline for pain in knee osteoarthritis: a double-blind randomised controlled trial in New Zealand general practice.
Topics: Adult; Double-Blind Method; General Practice; Humans; New Zealand; Nortriptyline; Osteoarthritis, Kn | 2021 |
Sensory complaints of the upper extremities in multiple sclerosis: relative efficacy of nortriptyline and transcutaneous electrical nerve stimulation.
Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Electric Stimulation Therapy; Female; Humans; M | 2009 |
Nortriptyline-fluphenazine vs. carbamazepine in the symptomatic treatment of diabetic neuropathy.
Topics: Adult; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Carbamazepine; Cross-Over Studies | 1996 |
Randomized trial of opioids versus tricyclic antidepressants for radiation-induced mucositis pain in head and neck cancer.
Topics: Aged; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Female; Head and Neck Neoplasms; Humans; | 2001 |
A randomized, within-patient, cross-over, placebo-controlled trial on the efficacy and tolerability of the tricyclic antidepressants chlorimipramine and nortriptyline in central pain.
Topics: Adult; Clomipramine; Double-Blind Method; Female; Humans; Male; Middle Aged; Nortriptyline; Pain; Pl | 1990 |
Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain.
Topics: Adult; Amitriptyline; Analgesics; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; | 1986 |
Nortriptyline and fluphenazine in the symptomatic treatment of diabetic neuropathy. A double-blind cross-over study.
Topics: Adult; Aged; Clinical Trials as Topic; Diabetic Neuropathies; Double-Blind Method; Female; Fluphenaz | 1985 |
[Clinical studies of a new analgesic in a double-blind trial].
Topics: Aminopyrine; Analgesics; Clinical Trials as Topic; Dextropropoxyphene; Humans; Nortriptyline; Pain; | 1970 |
20 other studies available for nortriptyline and Pain
| Article | Year |
|---|---|
Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity.
Topics: Analgesics; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Fluoxetine; Formaldehyde; gam | 2009 |
Antinociceptive effects of nortriptyline and desipramine hydrochloride in Speke's hinge-back tortoise (Kinixys Spekii).
Topics: Analgesics; Animals; Capsaicin; Desipramine; Formaldehyde; Nortriptyline; Pain; Turtles | 2023 |
Is Venlafaxine More Effective than Escitalopram and Nortriptyline in the Management of Painful Symptoms in Patients with Major Depression?
Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Female; Follow-Up Studies; Hum | 2018 |
Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing.
Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Interact | 2014 |
Painful traumatic trigeminal neuropathy: an open study on the pharmacotherapeutic response to stepped treatment.
Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Baclofen; Carbamazepine; Clinical Proto | 2014 |
Vulvodynia in preadolescent girls.
Topics: Antidepressive Agents, Tricyclic; Child; Child, Preschool; Chronic Disease; Female; Humans; Nortript | 2008 |
Persistent aching and itching of the clitoris.
Topics: Adrenergic Uptake Inhibitors; Adult; Clitoris; Female; Humans; Nortriptyline; Pain; Pruritus Vulvae; | 2013 |
Tricyclic antidepressants as long-acting local anesthetics.
Topics: Amines; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Cell Line; Dose-Response Rela | 2003 |
Interactions of cyclobenzaprine and tricyclic antidepressants.
Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Interactions; Humans; Mal | 2005 |
Chronic neuropathic pain associated with imiquimod: report of 2 cases.
Topics: Aminoquinolines; Antiviral Agents; Chronic Disease; Female; Humans; Imiquimod; Male; Middle Aged; No | 2005 |
Chronic orchialgia: consider gabapentin or nortriptyline before considering surgery.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Amines; Calcium Channel Blockers; Chronic Disease; Cycloh | 2007 |
Nortriptyline and neuropathic pain.
Topics: Antidepressive Agents, Tricyclic; Diabetic Neuropathies; Humans; Medication Errors; Nortriptyline; P | 1999 |
Cyclobenzaprine hydrochloride is a commonly prescribed centrally acting muscle relaxant, which is structurally similar to tricyclic antidepressants (TCAs) and differs from amitriptyline by only one double bond.
Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Drug Therapy, Combination; | 2001 |
Carotidynia.
Topics: Adult; Aged; Carotid Artery Diseases; Dose-Response Relationship, Drug; Ergonovine; Female; Headache | 1977 |
Lack of correlation between plasma levels of amitriptyline (and nortriptyline) and clinical improvement of chronic pain of peripheral neurologic origin.
Topics: Adult; Aged; Amitriptyline; Analgesics; Female; Humans; Male; Middle Aged; Nortriptyline; Pain; Pain | 1987 |
Effect of citalopram, amineptine, imipramine and nortriptyline on stress-induced (footshock) analgesia in rats.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Dibenzocycloheptenes; | 1987 |
Relief of postherpetic neuralgia with psychotropic drugs.
Topics: Aged; Amitriptyline; Analgesics; Antidepressive Agents; Antipsychotic Agents; Female; Fluphenazine; | 1973 |
Analgesic activity of some sympathetic drugs and their effect on morphine analgesia in rabbits.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A | 1969 |
[Therapy of polyneuritides].
Topics: Butyrophenones; Chlorpromazine; Glucocorticoids; Humans; Hypoxia; Imipramine; Methotrimeprazine; Nor | 1971 |
[On the management of pain using antidepressive agents].
Topics: Amitriptyline; Antidepressive Agents; Desipramine; Humans; Imipramine; Nortriptyline; Pain | 1967 |