Page last updated: 2024-11-01

nortriptyline and Pain

nortriptyline has been researched along with Pain in 30 studies

Nortriptyline: A metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
nortriptyline : An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(methylamino)propylidene group at position 5. It is an active metabolite of amitriptyline.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
" Adults with knee OA and a pain score of ≥20 points on the 50-point Western Ontario and McMaster University Osteoarthritis Index (WOMAC) pain subscale were randomised to receive either nortriptyline or identical placebo for 14 weeks."9.41Nortriptyline for pain in knee osteoarthritis: a double-blind randomised controlled trial in New Zealand general practice. ( Alchin, JS; Hooper, GJ; Hudson, B; Mangin, D; Stamp, LK; Thompson, BFL; Toop, L; Williman, JA, 2021)
"The aim of this study was to evaluate the relative efficacy of nortriptyline and self-applied transcutaneous electrical nerve stimulation (TENS) in the treatment of pain and/or sensory complaints of the upper extremities in people with multiple sclerosis (MS)."9.14Sensory complaints of the upper extremities in multiple sclerosis: relative efficacy of nortriptyline and transcutaneous electrical nerve stimulation. ( Ashtari, F; Chitsaz, A; Freeman, J; Heshmatipour, M; Janghorbani, M; Shaygannejad, V, 2009)
"The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks."9.06Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986)
"The GABA amides of the antidepressants nortriptyline and fluoxetine, 1 and 2, were compared to their respective parent compounds in rodent models of pain."7.75Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity. ( Aharoni, A; Geffen, Y; Gil-Ad, I; Halbfinger, E; Nisemblat, Y; Nudelman, A; Rephaeli, A; Tarasenko, I; Tarasenko, N; Weizman, A, 2009)
"Physicians caring for patients with CSPN should consider mexiletine to address pain and fatigue, although nortriptyline and duloxetine are better medications to trial first since they are better tolerated."5.51A secondary analysis of PAIN-CONTRoLS: Pain's impact on sleep, fatigue, and activities of daily living. ( Barohn, RJ; Bhai, SF; Brown, A; Gajewski, B; Kimminau, KS; Pasnoor, M; Waitman, LR, 2022)
"Key messagesPeripheral lidocaine and oestradiol and centrally-targeted nortriptyline medications are used for the treatment of pain in women with VBD, but there is a lack of data from well-powered RCTs."5.51Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe). ( Akaninwor, J; Bortsov, A; Carey, ET; Cutting, H; DeLaRosa, J; Farb, D; Geller, EJ; Luo, S; McNulty, S; Merrill, P; Nackley, AG; Rapkin, A; Stirling, C; Zakroysky, P, 2022)
" Adults with knee OA and a pain score of ≥20 points on the 50-point Western Ontario and McMaster University Osteoarthritis Index (WOMAC) pain subscale were randomised to receive either nortriptyline or identical placebo for 14 weeks."5.41Nortriptyline for pain in knee osteoarthritis: a double-blind randomised controlled trial in New Zealand general practice. ( Alchin, JS; Hooper, GJ; Hudson, B; Mangin, D; Stamp, LK; Thompson, BFL; Toop, L; Williman, JA, 2021)
"The aim of this study was to evaluate the relative efficacy of nortriptyline and self-applied transcutaneous electrical nerve stimulation (TENS) in the treatment of pain and/or sensory complaints of the upper extremities in people with multiple sclerosis (MS)."5.14Sensory complaints of the upper extremities in multiple sclerosis: relative efficacy of nortriptyline and transcutaneous electrical nerve stimulation. ( Ashtari, F; Chitsaz, A; Freeman, J; Heshmatipour, M; Janghorbani, M; Shaygannejad, V, 2009)
"The analgesic and antidepressive effects of amitriptyline (AT) in relation to its kinetics and metabolism were studied in 19 outpatients with chronic pain who received a daily dose of 75 mg AT for at least 6 weeks."5.06Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain. ( de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG, 1986)
"A controlled clinical trial on the efficacy of a nortriptyline-fluphenazine combination was carried out in patients with painful diabetic polyneuropathy."5.05Nortriptyline and fluphenazine in the symptomatic treatment of diabetic neuropathy. A double-blind cross-over study. ( Dies, H; Gomez-Perez, FJ; Gonzalez-Barranco, J; Lozano-Castañeda, O; Rodriguez-Rivera, GJ; Rull, JA, 1985)
"Urinary excretion data were obtained from 55,296 patients with pain and were analyzed using liquid chromatography tandem mass spectrometry in a multiplex assay which included amitriptyline, nortriptyline, and imipramine."3.80Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing. ( Atayee, RS; Best, BM; Bordson, SJ; Ma, JD, 2014)
"The GABA amides of the antidepressants nortriptyline and fluoxetine, 1 and 2, were compared to their respective parent compounds in rodent models of pain."3.75Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity. ( Aharoni, A; Geffen, Y; Gil-Ad, I; Halbfinger, E; Nisemblat, Y; Nudelman, A; Rephaeli, A; Tarasenko, I; Tarasenko, N; Weizman, A, 2009)
"Although this is a small study, it appears that gabapentin and nortriptyline are effective in the treatment of idiopathic chronic orchialgia but not post-vasectomy pain."3.74Chronic orchialgia: consider gabapentin or nortriptyline before considering surgery. ( Lee, LK; Miller, B; Sinclair, AM, 2007)
"The pain is characterized by a burning or stinging sensation similar to neuropathic pain sensations."2.70Randomized trial of opioids versus tricyclic antidepressants for radiation-induced mucositis pain in head and neck cancer. ( Andersen, J; Ehrnrooth, E; Grau, C; Zachariae, R, 2001)
"The responsiveness of both migraine headaches and carotidynia to similar drugs suggests a common pathophysiologic mechanism."1.26Carotidynia. ( Prusiner, S; Raskin, NH, 1977)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199010 (33.33)18.7374
1990's3 (10.00)18.2507
2000's9 (30.00)29.6817
2010's4 (13.33)24.3611
2020's4 (13.33)2.80

Authors

AuthorsStudies
Rephaeli, A1
Gil-Ad, I1
Aharoni, A1
Tarasenko, I1
Tarasenko, N1
Geffen, Y1
Halbfinger, E1
Nisemblat, Y1
Weizman, A1
Nudelman, A1
Bhai, SF1
Brown, A1
Gajewski, B1
Kimminau, KS1
Waitman, LR1
Pasnoor, M1
Barohn, RJ1
Carey, ET1
Geller, EJ1
Rapkin, A1
Farb, D1
Cutting, H1
Akaninwor, J1
Stirling, C1
Bortsov, A1
McNulty, S1
Merrill, P1
Zakroysky, P1
DeLaRosa, J1
Luo, S1
Nackley, AG1
Makau, CM1
Towett, PK1
Kanui, TI1
Abelson, KSP1
Hudson, B1
Williman, JA1
Stamp, LK1
Alchin, JS1
Hooper, GJ1
Mangin, D1
Thompson, BFL1
Toop, L1
Jaracz, J1
Gattner, K1
Jaracz, K1
Górna, K1
Moczko, J1
Hauser, J1
Bordson, SJ1
Atayee, RS1
Ma, JD1
Best, BM1
Haviv, Y1
Zadik, Y1
Sharav, Y1
Benoliel, R1
Reed, BD1
Cantor, LE1
Chitsaz, A1
Janghorbani, M1
Shaygannejad, V1
Ashtari, F1
Heshmatipour, M1
Freeman, J1
Verstraelen, H1
Roelens, K1
De Knijf, A1
Temmerman, M1
Sudoh, Y1
Cahoon, EE1
Gerner, P1
Wang, GK1
Rosenlicht, NZ1
Riley-Lazo, KP1
Yi, BA1
Nirenberg, MJ1
Goldstein, SM1
Berger, TG1
Sinclair, AM1
Miller, B1
Lee, LK1
Gómez-Pérez, FJ2
Choza, R1
Ríos, JM1
Reza, A1
Huerta, E1
Aguilar, CA1
Rull, JA2
Cohen, H1
Cohen, MR1
Lofland, JH1
Szarlej, D1
Buttaro, T1
Shermock, S1
Jalali, S1
Ehrnrooth, E1
Grau, C1
Zachariae, R1
Andersen, J1
Raskin, NH1
Prusiner, S1
Panerai, AE1
Monza, G1
Movilia, P1
Bianchi, M1
Francucci, BM1
Tiengo, M1
Rascol, O1
Tran, MA1
Bonnevialle, P1
Belin, J1
Cotonat, J1
Guiraud-Chaumeil, B1
Montastruc, JL1
Testa, R1
Angelico, P1
Abbiati, GA1
Edelbroek, PM1
Linssen, AC1
Zitman, FG1
Rooymans, HG1
de Wolff, FA1
Dies, H1
Rodriguez-Rivera, GJ1
Gonzalez-Barranco, J1
Lozano-Castañeda, O1
Taub, A1
Saarnivaara, L1
Végh, J1
Kaeser, HE1
Opitz, K1
Borchert, U1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prospective, Cross Over Gabapentin vs Amitriptyline Study on Patients Suffering From Masticatory Muscle Pain[NCT02339662]Phase 450 participants (Anticipated)Interventional2015-02-28Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

10 trials available for nortriptyline and Pain

ArticleYear
A secondary analysis of PAIN-CONTRoLS: Pain's impact on sleep, fatigue, and activities of daily living.
    Muscle & nerve, 2022, Volume: 66, Issue:4

    Topics: Activities of Daily Living; Bayes Theorem; Diabetic Neuropathies; Double-Blind Method; Duloxetine Hy

2022
Rationale and design of a multicenter randomized clinical trial of vestibulodynia: understanding pathophysiology and determining appropriate treatments (vestibulodynia: UPDATe).
    Annals of medicine, 2022, Volume: 54, Issue:1

    Topics: Antidepressive Agents, Tricyclic; Cytokines; Estradiol; Female; Humans; Lidocaine; MicroRNAs; Multic

2022
Nortriptyline for pain in knee osteoarthritis: a double-blind randomised controlled trial in New Zealand general practice.
    The British journal of general practice : the journal of the Royal College of General Practitioners, 2021, Volume: 71, Issue:708

    Topics: Adult; Double-Blind Method; General Practice; Humans; New Zealand; Nortriptyline; Osteoarthritis, Kn

2021
Sensory complaints of the upper extremities in multiple sclerosis: relative efficacy of nortriptyline and transcutaneous electrical nerve stimulation.
    The Clinical journal of pain, 2009, Volume: 25, Issue:4

    Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Electric Stimulation Therapy; Female; Humans; M

2009
Nortriptyline-fluphenazine vs. carbamazepine in the symptomatic treatment of diabetic neuropathy.
    Archives of medical research, 1996,Winter, Volume: 27, Issue:4

    Topics: Adult; Analgesics, Non-Narcotic; Antidepressive Agents, Tricyclic; Carbamazepine; Cross-Over Studies

1996
Randomized trial of opioids versus tricyclic antidepressants for radiation-induced mucositis pain in head and neck cancer.
    Acta oncologica (Stockholm, Sweden), 2001, Volume: 40, Issue:6

    Topics: Aged; Analgesics, Opioid; Antidepressive Agents, Tricyclic; Female; Head and Neck Neoplasms; Humans;

2001
A randomized, within-patient, cross-over, placebo-controlled trial on the efficacy and tolerability of the tricyclic antidepressants chlorimipramine and nortriptyline in central pain.
    Acta neurologica Scandinavica, 1990, Volume: 82, Issue:1

    Topics: Adult; Clomipramine; Double-Blind Method; Female; Humans; Male; Middle Aged; Nortriptyline; Pain; Pl

1990
Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain.
    Clinical pharmacology and therapeutics, 1986, Volume: 39, Issue:2

    Topics: Adult; Amitriptyline; Analgesics; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic;

1986
Nortriptyline and fluphenazine in the symptomatic treatment of diabetic neuropathy. A double-blind cross-over study.
    Pain, 1985, Volume: 23, Issue:4

    Topics: Adult; Aged; Clinical Trials as Topic; Diabetic Neuropathies; Double-Blind Method; Female; Fluphenaz

1985
[Clinical studies of a new analgesic in a double-blind trial].
    Zeitschrift fur Allgemeinmedizin, 1970, May-31, Volume: 46, Issue:15

    Topics: Aminopyrine; Analgesics; Clinical Trials as Topic; Dextropropoxyphene; Humans; Nortriptyline; Pain;

1970

Other Studies

20 other studies available for nortriptyline and Pain

ArticleYear
Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity.
    Journal of medicinal chemistry, 2009, May-14, Volume: 52, Issue:9

    Topics: Analgesics; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Fluoxetine; Formaldehyde; gam

2009
Antinociceptive effects of nortriptyline and desipramine hydrochloride in Speke's hinge-back tortoise (Kinixys Spekii).
    Fundamental & clinical pharmacology, 2023, Volume: 37, Issue:3

    Topics: Analgesics; Animals; Capsaicin; Desipramine; Formaldehyde; Nortriptyline; Pain; Turtles

2023
Is Venlafaxine More Effective than Escitalopram and Nortriptyline in the Management of Painful Symptoms in Patients with Major Depression?
    Pharmacopsychiatry, 2018, Volume: 51, Issue:4

    Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Female; Follow-Up Studies; Hum

2018
Tricyclic antidepressants: is your patient taking them? Observations on adherence and unreported use using prescriber-reported medication lists and urine drug testing.
    Pain medicine (Malden, Mass.), 2014, Volume: 15, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Amitriptyline; Antidepressive Agents, Tricyclic; Drug Interact

2014
Painful traumatic trigeminal neuropathy: an open study on the pharmacotherapeutic response to stepped treatment.
    Journal of oral & facial pain and headache, 2014,Winter, Volume: 28, Issue:1

    Topics: Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Baclofen; Carbamazepine; Clinical Proto

2014
Vulvodynia in preadolescent girls.
    Journal of lower genital tract disease, 2008, Volume: 12, Issue:4

    Topics: Antidepressive Agents, Tricyclic; Child; Child, Preschool; Chronic Disease; Female; Humans; Nortript

2008
Persistent aching and itching of the clitoris.
    Archives of gynecology and obstetrics, 2013, Volume: 288, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Adult; Clitoris; Female; Humans; Nortriptyline; Pain; Pruritus Vulvae;

2013
Tricyclic antidepressants as long-acting local anesthetics.
    Pain, 2003, Volume: 103, Issue:1-2

    Topics: Amines; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Cell Line; Dose-Response Rela

2003
Interactions of cyclobenzaprine and tricyclic antidepressants.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:1

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Depressive Disorder; Drug Interactions; Humans; Mal

2005
Chronic neuropathic pain associated with imiquimod: report of 2 cases.
    Journal of the American Academy of Dermatology, 2005, Volume: 52, Issue:2 Suppl 1

    Topics: Aminoquinolines; Antiviral Agents; Chronic Disease; Female; Humans; Imiquimod; Male; Middle Aged; No

2005
Chronic orchialgia: consider gabapentin or nortriptyline before considering surgery.
    International journal of urology : official journal of the Japanese Urological Association, 2007, Volume: 14, Issue:7

    Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Amines; Calcium Channel Blockers; Chronic Disease; Cycloh

2007
Nortriptyline and neuropathic pain.
    The Nurse practitioner, 1999, Volume: 24, Issue:4

    Topics: Antidepressive Agents, Tricyclic; Diabetic Neuropathies; Humans; Medication Errors; Nortriptyline; P

1999
Cyclobenzaprine hydrochloride is a commonly prescribed centrally acting muscle relaxant, which is structurally similar to tricyclic antidepressants (TCAs) and differs from amitriptyline by only one double bond.
    The Clinical journal of pain, 2001, Volume: 17, Issue:1

    Topics: Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Chronic Disease; Drug Therapy, Combination;

2001
Carotidynia.
    Neurology, 1977, Volume: 27, Issue:1

    Topics: Adult; Aged; Carotid Artery Diseases; Dose-Response Relationship, Drug; Ergonovine; Female; Headache

1977
Lack of correlation between plasma levels of amitriptyline (and nortriptyline) and clinical improvement of chronic pain of peripheral neurologic origin.
    Clinical neuropharmacology, 1987, Volume: 10, Issue:6

    Topics: Adult; Aged; Amitriptyline; Analgesics; Female; Humans; Male; Middle Aged; Nortriptyline; Pain; Pain

1987
Effect of citalopram, amineptine, imipramine and nortriptyline on stress-induced (footshock) analgesia in rats.
    Pain, 1987, Volume: 29, Issue:2

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Citalopram; Dibenzocycloheptenes;

1987
Relief of postherpetic neuralgia with psychotropic drugs.
    Journal of neurosurgery, 1973, Volume: 39, Issue:2

    Topics: Aged; Amitriptyline; Analgesics; Antidepressive Agents; Antipsychotic Agents; Female; Fluphenazine;

1973
Analgesic activity of some sympathetic drugs and their effect on morphine analgesia in rabbits.
    Annales medicinae experimentalis et biologiae Fenniae, 1969, Volume: 47, Issue:3

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adrenergic beta-A

1969
[Therapy of polyneuritides].
    Deutsche medizinische Wochenschrift (1946), 1971, Sep-03, Volume: 96, Issue:36

    Topics: Butyrophenones; Chlorpromazine; Glucocorticoids; Humans; Hypoxia; Imipramine; Methotrimeprazine; Nor

1971
[On the management of pain using antidepressive agents].
    Klinische Wochenschrift, 1967, Sep-01, Volume: 45, Issue:17

    Topics: Amitriptyline; Antidepressive Agents; Desipramine; Humans; Imipramine; Nortriptyline; Pain

1967