kaempferol 3-o-rhamnoside profile

kaempferol 3-O-rhamnoside: from apple (Malus domestica) leaves; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

afzelin : A glycosyloxyflavone that is kaempferol attached to an alpha-L-rhamnosyl residue at position 3 via a glycosidic linkage. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	5316673
CHEMBL ID	240528
CHEBI ID	80790
SCHEMBL ID	1689477
MeSH ID	M0444413

Synonym
kaempferol-3-o-rhamnoside
afzelin
482-39-3
kaempferol 3-rhamnoside
4h-1-benzopyran-4-one, 3-[(6-deoxy-.alpha.-l-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-
5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxy-chromen-4-one
MEGXP0_000339
ACON1_000149
kaempferol-3-rhamnoside
kaempferol-3-o-alpha-l-rhamnopyranoside
CHEMBL240528 ,
chebi:80790 ,
C16911
kaempferin
kaempferol 3-o-alpha-l-rhamnoside
kaempferol 3-o-alpha-l-rhamnopyranoside
bdbm50213414
kaempferol 3-o-rhamnoside
5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4h-chromen-3-yl 6-deoxy-alpha-l-mannopyranoside
AFE ,
5m86w1yh7o ,
4h-1-benzopyran-4-one, 3-((6-deoxy-alpha-l-mannopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
kaempferol-3-o-beta-rhamnoside
unii-5m86w1yh7o
kaempherol 3-o-alpha-rhamnoside
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4h-chromen-3-yl alpha-l-rhamnoside
SCHEMBL1689477
5,7-dihydroxy-2-(4-hydroxyphenyl)-3-(((2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yl)oxy)-4h-chromen-4-one
kaempferol 3-o-glucorhamnoside
kaempferol 3-o-rhamnopyranoside
kaempferol 3-l-rhamnoside
3-o-.alpha.-l-rhamnopyranosylkaempferol
kaempferol 3-o-.alpha.-l-rhamnoside
3-((6-deoxy-.alpha.-l-mannopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one
kaempferol 3-(6-deoxy-l-mannopyranoside)
4h-1-benzopyran-4-one, 3-((6-deoxy-.alpha.-l-mannopyranosyl)oxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
kaempferol-3-.alpha.-l-rhamnose
kaempferol 3-.alpha.-l-rhamnopyranoside
786711-07-7
kaempferol 3-o-.alpha.-l-rhamnopyranoside
kaempherol 3-o-.alpha.-l-rhamnopyranoside
kaempherol 3-o-.alpha.-rhamnoside
afzeloside
kaempferol rhamnoside
kaempferol rhamnoside [inci]
mfcd17676152
DTXSID50197459
afzelin, >=90% (lc/ms-uv)
5,7-dihydroxy-2-(4-hydroxyphenyl)-3-((2s,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyltetrahydro-2h-pyran-2-yloxy)-4h-chromen-4-one
afzelin; kaempherol 3-o-alpha-rhamnoside
AKOS032962059
Q3334749
A13891
CS-0016878
HY-N1441
A854406

Excerpt	Reference	Relevance
" The accumulated aggregates were smaller, soluble, non-β-sheet and non-toxic aggregates, compared to preformed toxic Aβ oligomers."	( Keampferol-3-O-rhamnoside abrogates amyloid beta toxicity by modulating monomers and remodeling oligomers and fibrils to non-toxic aggregates. Park, IS; Ramasamy, VS; Shahnawaz, M; Sharoar, MG; Shin, SY; Thapa, A; Woo, ER, 2012)	0.38

Role	Description
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
antibacterial agent	A substance (or active part thereof) that kills or slows the growth of bacteria.
anti-inflammatory agent	Any compound that has anti-inflammatory effects.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
glycosyloxyflavone	A member of the class of flavones having one or more glycosyl residues attached at unspecified positions.
trihydroxyflavone	Any hydroxyflavone carrying three hydroxy groups at unspecified positions.
monosaccharide derivative	A carbohydrate derivative that is formally obtained from a monosaccharide.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
Flavone and Flavonol Biosynthesis	6	27

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Polyphenol oxidase 2	Agaricus bisporus	IC50 (µMol)	400.0000	0.0340	3.9871	10.0000	AID539042
Cytochrome P450 3A4	Homo sapiens (human)	IC50 (µMol)	100.0000	0.0001	1.7536	10.0000	AID402936
Cytochrome P450 2D6	Homo sapiens (human)	IC50 (µMol)	100.0000	0.0000	2.0151	10.0000	AID402937
Nitric oxide synthase, inducible	Mus musculus (house mouse)	IC50 (µMol)	50.0000	0.0010	3.3911	9.6000	AID344829
E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)	IC50 (µMol)	100.0000	0.0075	0.6227	4.1000	AID550523
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
lipid hydroxylation	Cytochrome P450 3A4	Homo sapiens (human)
lipid metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
steroid catabolic process	Cytochrome P450 3A4	Homo sapiens (human)
xenobiotic metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
steroid metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
cholesterol metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
androgen metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
estrogen metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
alkaloid catabolic process	Cytochrome P450 3A4	Homo sapiens (human)
monoterpenoid metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
calcitriol biosynthetic process from calciol	Cytochrome P450 3A4	Homo sapiens (human)
xenobiotic catabolic process	Cytochrome P450 3A4	Homo sapiens (human)
vitamin D metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
vitamin D catabolic process	Cytochrome P450 3A4	Homo sapiens (human)
retinol metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
retinoic acid metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
long-chain fatty acid biosynthetic process	Cytochrome P450 3A4	Homo sapiens (human)
aflatoxin metabolic process	Cytochrome P450 3A4	Homo sapiens (human)
oxidative demethylation	Cytochrome P450 3A4	Homo sapiens (human)
xenobiotic metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
steroid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
cholesterol metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
estrogen metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
coumarin metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
alkaloid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
alkaloid catabolic process	Cytochrome P450 2D6	Homo sapiens (human)
monoterpenoid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
isoquinoline alkaloid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
xenobiotic catabolic process	Cytochrome P450 2D6	Homo sapiens (human)
retinol metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
long-chain fatty acid biosynthetic process	Cytochrome P450 2D6	Homo sapiens (human)
negative regulation of binding	Cytochrome P450 2D6	Homo sapiens (human)
oxidative demethylation	Cytochrome P450 2D6	Homo sapiens (human)
negative regulation of cellular organofluorine metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
arachidonic acid metabolic process	Cytochrome P450 2D6	Homo sapiens (human)
regulation of apoptotic process	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
DNA damage response	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
negative regulation of tumor necrosis factor-mediated signaling pathway	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
Wnt signaling pathway	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
regulation of BMP signaling pathway	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
positive regulation of protein ubiquitination	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
positive regulation of type I interferon production	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
regulation of cell population proliferation	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
defense response to bacterium	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
negative regulation of apoptotic process	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
positive regulation of canonical NF-kappaB signal transduction	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
regulation of innate immune response	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
positive regulation of JNK cascade	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
regulation of inflammatory response	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
neuron apoptotic process	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
copper ion homeostasis	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
regulation of apoptosis involved in tissue homeostasis	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
nucleotide-binding oligomerization domain containing 1 signaling pathway	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
nucleotide-binding oligomerization domain containing 2 signaling pathway	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
protein K63-linked ubiquitination	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
positive regulation of canonical Wnt signaling pathway	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
inhibition of cysteine-type endopeptidase activity	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
positive regulation of protein linear polyubiquitination	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
regulation of cell cycle	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
monooxygenase activity	Cytochrome P450 3A4	Homo sapiens (human)
steroid binding	Cytochrome P450 3A4	Homo sapiens (human)
iron ion binding	Cytochrome P450 3A4	Homo sapiens (human)
protein binding	Cytochrome P450 3A4	Homo sapiens (human)
steroid hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
retinoic acid 4-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
oxidoreductase activity	Cytochrome P450 3A4	Homo sapiens (human)
oxygen binding	Cytochrome P450 3A4	Homo sapiens (human)
enzyme binding	Cytochrome P450 3A4	Homo sapiens (human)
heme binding	Cytochrome P450 3A4	Homo sapiens (human)
vitamin D3 25-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
caffeine oxidase activity	Cytochrome P450 3A4	Homo sapiens (human)
quinine 3-monooxygenase activity	Cytochrome P450 3A4	Homo sapiens (human)
testosterone 6-beta-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
anandamide 8,9 epoxidase activity	Cytochrome P450 3A4	Homo sapiens (human)
anandamide 11,12 epoxidase activity	Cytochrome P450 3A4	Homo sapiens (human)
anandamide 14,15 epoxidase activity	Cytochrome P450 3A4	Homo sapiens (human)
aromatase activity	Cytochrome P450 3A4	Homo sapiens (human)
vitamin D 24-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
estrogen 16-alpha-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
estrogen 2-hydroxylase activity	Cytochrome P450 3A4	Homo sapiens (human)
1,8-cineole 2-exo-monooxygenase activity	Cytochrome P450 3A4	Homo sapiens (human)
monooxygenase activity	Cytochrome P450 2D6	Homo sapiens (human)
iron ion binding	Cytochrome P450 2D6	Homo sapiens (human)
oxidoreductase activity	Cytochrome P450 2D6	Homo sapiens (human)
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	Cytochrome P450 2D6	Homo sapiens (human)
heme binding	Cytochrome P450 2D6	Homo sapiens (human)
anandamide 8,9 epoxidase activity	Cytochrome P450 2D6	Homo sapiens (human)
anandamide 11,12 epoxidase activity	Cytochrome P450 2D6	Homo sapiens (human)
anandamide 14,15 epoxidase activity	Cytochrome P450 2D6	Homo sapiens (human)
ubiquitin-protein transferase activity	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
cysteine-type endopeptidase inhibitor activity	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
protein binding	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
identical protein binding	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
metal ion binding	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
endopeptidase regulator activity	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
ubiquitin protein ligase activity	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
protein serine/threonine kinase binding	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
cytoplasm	Cytochrome P450 3A4	Homo sapiens (human)
endoplasmic reticulum membrane	Cytochrome P450 3A4	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 3A4	Homo sapiens (human)
mitochondrion	Cytochrome P450 2D6	Homo sapiens (human)
endoplasmic reticulum	Cytochrome P450 2D6	Homo sapiens (human)
endoplasmic reticulum membrane	Cytochrome P450 2D6	Homo sapiens (human)
cytoplasm	Cytochrome P450 2D6	Homo sapiens (human)
intracellular membrane-bounded organelle	Cytochrome P450 2D6	Homo sapiens (human)
cytoplasm	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
nucleus	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
nucleoplasm	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
cytoplasm	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
cytosol	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
nucleus	E3 ubiquitin-protein ligase XIAP	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (204)

Assay ID	Title	Year	Journal	Article
AID1347365	SDT Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347372	qHTS for Constitutive Androstane Receptor (CAR) Antagonist screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347355	HEK-293 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347346	HPAF-II Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347381	Inflammasome Signaling qHTS Counterscreen: IL-1-beta AlphaLISA counterscreen against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347369	MCF7 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347358	HPAF-II 12hr Apoptosis Induction qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347363	Firefly luciferase counterscreen qHTS: Assay Interference Panel against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347371	J3T Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347361	HEK293 12hr Apoptosis Induction qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347373	qHTS for Constitutive Androstane Receptor (CAR) Agonist screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347392	qHTS for activators of dead-cell proteases activity screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347359	HEK293 24hr Apoptosis Induction qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347356	HPAF-II 24hr Apoptosis Induction qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347389	qHTS assay for small molecule disruptors of mitochondrial membrane potential screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347391	qHTS for activators of Nrf2/ARE signaling pathway screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347357	HEK293 18hr Apoptosis Induction qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347362	Diaphorse counterscreen qHTS: Assay Interference Panel against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347393	qHTS for inhibitors of ER calcium dysfunction: SERCaMP assay screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347351	U-118MG Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347377	DH5-alpha competent E. coli microbial cell viability qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347347	UWB1.289 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347376	10-beta competent E. coli microbial cell viability qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347379	qHTS for Inflammasome Signaling Inhibitors: IL-1-beta AlphaLISA screen against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347375	qHTS for Hypoxia signaling pathway (HIF-1) agonists against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347366	KB-3-1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347360	HPAF-II 18hr Apoptosis Induction qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347348	OV-SAHO Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347370	qHTS for ATAD5 Antagonist screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347388	qHTS for Activators of p53 Stress Response Pathway screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347367	qHTS for ATAD5 Agonist screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347364	KB-8-5-11 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347378	qHTS for H2AX Agonists against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347380	qHTS for Antimalaria activity screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347396	qHTS for inhibitors of Wild type Zika virus screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347401	Redox Reaction Profiling qHTS: Assay Interference Panel against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347390	Secretion counterscreen for inhibitors of the SERCaMP assay screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347353	A2780 Cisplatin Sensitive Ovarian Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347374	qHTS for Hypoxia signaling pathway (HIF-1) antagonists against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347352	COV-362 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347160	Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors	2020	Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49	Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347345	OV-KATE Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347350	SW1088 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347400	Viability qHTS for inhibitors of the SERCaMP assay screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347368	G06 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347402	qHTS for inhibitors of Rabies Virus screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347349	Panc-1005 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347387	Cytotoxicity qHTS for assessment of Hepg2 cells membrane integrity screened against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347394	Vero-766 cells viability qHTS against the NCATS CANVASS Library: Counterscreen for Zika virus inhibition assay	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1347354	UWB1.289-WTBRCA1 Cancer Cell Toxicity qHTS against the NCATS CANVASS Library	2018	ACS central science, Dec-26, Volume: 4, Issue:12	Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
AID1660424	Diuretic activity in normotensive Wistar rat assessed as urinary sodium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of L-NAME (Rvb = 61.82 to 80.81 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID357259	DNA damaging activity against YCp50 transformed Saccharomyces cerevisiae in glucose minimal medium after 41 hrs	2002	Journal of natural products, Dec, Volume: 65, Issue:12	DNA-damaging agents from Crypteronia paniculata.
AID1660351	Diuretic activity in normotensive Wistar rat assessed as increase in urine volume excretion at 0.1 to 1 mg/kg, po administered via gavage after 1 hr	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1376875	Cytotoxicity against human DeFew cells at 10 to 100 uM by MTT assay
AID1660372	Diuretic activity in normotensive Wistar rat assessed as urine conductivity at 1 mg/kg, ip after 8 hrs (Rvb = 24.87 +/- 0.54 mS/cm)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660365	Diuretic activity in normotensive Wistar rat assessed as urine pH at 1 mg/kg, ip after 8 hrs (Rvb = 6.05 +/- 0.22 No_unit)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1766075	Cytotoxicity against in mouse 3T3-L1 cells assessed as reduction in cell viability at 100 uM incubated for 24 hrs by MTT assay relative to control	2021	Bioorganic & medicinal chemistry letters, 10-01, Volume: 49	Phytochemicals from the flowers of Prunus persica (L.) Batsch: Anti-adipogenic effect of mandelamide on 3T3-L1 preadipocytes.
AID1660368	Diuretic activity in normotensive Wistar rat assessed as urine conductivity at 0.1 mg/kg, po administered via gavage after 8 hrs (Rvb = 19.54 +/- 0.98 mS/cm)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID308088	Inhibition of RSK expressed in SF9 cells	2007	Bioorganic & medicinal chemistry, Jul-15, Volume: 15, Issue:14	Structural basis for the activity of the RSK-specific inhibitor, SL0101.
AID1376887	Antimicrobial activity against Escherichia coli DSM 8579 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter)
AID1660416	Diuretic activity in normotensive Wistar rat assessed as urine conductivity at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of L-NAME (Rvb = 19.54 +/- 0.98 mS/cm)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1376874	Cytotoxicity against human A549 cells at 10 to 100 uM by MTT assay
AID1660473	Toxicity in spontaneous hypertensive Wistar rat assessed as changes in plasma chloride level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660383	Diuretic activity in normotensive Wistar rat assessed as urinary potassium excretion at 1 mg/kg, po administered via gavage after 8 hrs (Rvb = 22.39 to 24.21 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660468	Toxicity in normotensive Wistar rat assessed as changes in plasma sodium level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660427	Diuretic activity in normotensive Wistar rat assessed as urinary potassium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of hydrochlorothiazide (Rvb = 22.39 to 24.21 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660500	Anti-urolithic activity in normotensive Wistar rats assessed as reduction in CaOx crystal formation in cumulative urine at 0.1 mg/kg, po administered via gavage in presence of sodium oxalate by Neubauer counting chamber method relative to control	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660415	Diuretic activity in normotensive Wistar rat assessed as urine conductivity at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of atropine (Rvb = 19.54 +/- 0.98 mS/cm)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID332706	Inhibition of human plasma alternative complement system assessed as hemolysis of non-sensitized rabbit erythrocytes at 1000 uM	1995	Journal of natural products, Mar, Volume: 58, Issue:3	In vitro anticomplementary activity of constituents from Morinda morindoides.
AID402937	Inhibition of human CYP2D6 by radiometric assay	2004	Journal of natural products, Jul, Volume: 67, Issue:7	Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities.
AID1660419	Diuretic activity in normotensive Wistar rat assessed as urinary sodium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of hydrochlorothiazide (Rvb = 61.82 to 80.81 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660377	Diuretic activity in normotensive Wistar rat assessed as urinary sodium excretion at 0.01 mg/kg, ip after 8 hrs (Rvb = 81.56 +/- 13.10 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1376872	Antioxidant activity in human plasma assessed as inhibition of H2O2-induced lipid peroxidation at 10 uM after 30 mins by TBARS assay relative to control
AID1660386	Diuretic activity in normotensive Wistar rat assessed as urinary potassium excretion at 1 mg/kg, ip administered via gavage after 8 hrs (Rvb = 22.33 +/- 2.81 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660390	Diuretic activity in normotensive Wistar rat assessed as urinary chloride excretion at 1 mg/kg, po administered via gavage after 8 hrs (Rvb = 135.10 to 143.70 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660504	Anti-urolithic activity in synthetic urine assessed as reduction in CaOx crystal formation at 0.01 mg/mL in presence of sodium oxalate after 60 mins by Neubauer counting chamber method relative to control	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660472	Toxicity in normotensive Wistar rat assessed as changes in plasma chloride level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660439	Diuretic activity in normotensive Wistar rat assessed as urinary chloride excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of atropine (Rvb = 135.10 to 143.70 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID308092	Antiproliferative activity against human MCF7 cells after 48 hrs	2007	Bioorganic & medicinal chemistry, Jul-15, Volume: 15, Issue:14	Structural basis for the activity of the RSK-specific inhibitor, SL0101.
AID1660507	Anti-urolithic activity in synthetic urine assessed as decrease in absorption at 0.1 mg/mL relative to control	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660489	In vivo antioxidant activity in Wistar rat model of hypertension-induced oxidative stress assessed as reduction in reactive oxygen species generation in renal tissue at 0.1 mg/kg, po administered via gavage for 7 days by DCFH-DA probe based fluorimetric a	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660469	Toxicity in spontaneous hypertensive Wistar rat assessed as changes in plasma sodium level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID344829	Inhibition of iNOS-mediated NO production in LPS-induced mouse BV2 cells	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	New diterpenoids and the bioactivity of Erythrophleum fordii.
AID1660453	Diuretic activity in normotensive Wistar rat assessed as increase in urinary sodium excretion at 0.1 mg/kg, po administered via gavage for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID550523	Displacement of fluorescent SM5F peptide from XIAP linker BIR3 domain after 3 hrs by fluorescence polarization assay	2011	Bioorganic & medicinal chemistry, Jan-15, Volume: 19, Issue:2	In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3.
AID539042	Inhibition of mushroom tyrosinase after 20 mins by spectrophotometric analysis	2010	Bioorganic & medicinal chemistry letters, Dec-15, Volume: 20, Issue:24	Changes in flavonoid content and tyrosinase inhibitory activity in kenaf leaf extract after far-infrared treatment.
AID1660374	Diuretic activity in normotensive Wistar rat assessed as urinary sodium excretion at 0.01 mg/kg, po administered via gavage after 8 hrs (Rvb = 61.82 to 80.81 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660482	Toxicity in normotensive Wistar rat assessed as changes in plasma nitrite acid level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660407	Diuretic activity in normotensive Wistar rat assessed as urine pH at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of atropine (Rvb = 6.14 to 6.21 No_unit)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660371	Diuretic activity in normotensive Wistar rat assessed as urine conductivity at 0.1 mg/kg, ip after 8 hrs (Rvb = 24.87 +/- 0.54 mS/cm)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1376889	Antimicrobial activity against Pseudomonas aeruginosa DSM 50071 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter)
AID355748	Inhibition of Saccharomyces cerevisiae FAS	2003	Journal of natural products, Apr, Volume: 66, Issue:4	Phenolic compounds from Nymphaea odorata.
AID1660445	Diuretic activity in normotensive Wistar rat assessed as urinary calcium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of amiloride (Rvb = 5.93 to 6.87 mg/dl)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660496	Renal protective activity in spontaneous hypertensive Wistar rat assessed as reduction in hypertension-induced mesangial space disarrangement at 0.1 mg/kg, po administered via gavage for 7 days by hematoxylin and eosin staining based microscopic analysis	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660508	Anti-urolithic activity in synthetic urine assessed as decrease in absorbance at 0.1 mg/mL after 30 mins relative to control	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660485	Toxicity in spontaneous hypertensive Wistar rat assessed as changes in urinary creatinine at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660382	Diuretic activity in normotensive Wistar rat assessed as urinary potassium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs (Rvb = 22.39 to 24.21 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660458	Diuretic activity in normotensive Wistar rat assessed as effect on urinary potassium excretion at 0.1 mg/kg, po administered via gavage for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660484	Toxicity in normotensive Wistar rat assessed as changes in urinary creatinine at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID332704	Inhibition of guinea pig classical complement system assessed as hemolysis of sensitized sheep erythrocytes at 1000 uM	1995	Journal of natural products, Mar, Volume: 58, Issue:3	In vitro anticomplementary activity of constituents from Morinda morindoides.
AID1660384	Diuretic activity in normotensive Wistar rat assessed as urinary potassium excretion at 0.01 mg/kg, ip administered via gavage after 8 hrs (Rvb = 22.33 +/- 2.81 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660457	Diuretic activity in spontaneous hypertensive Wistar rat assessed as decrease in urinary calcium excretion at 0.1 mg/kg, po administered via gavage for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660406	Diuretic activity in normotensive Wistar rat assessed as urine pH at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of indomethacin (Rvb = 6.14 to 6.21 No_unit)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660436	Diuretic activity in normotensive Wistar rat assessed as urinary chloride excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of furosemide (Rvb = 135.10 to 143.70 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1376886	Antimicrobial activity against Bacillus cereus DSM 4384 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter)
AID399391	Inhibition of HIV1 recombinant integrase expressed in Escherichia coli	1998	Journal of natural products, Jan, Volume: 61, Issue:1	A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase.
AID1660385	Diuretic activity in normotensive Wistar rat assessed as urinary potassium excretion at 0.1 mg/kg, ip administered via gavage after 8 hrs (Rvb = 22.33 +/- 2.81 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660378	Diuretic activity in normotensive Wistar rat assessed as urinary sodium excretion at 0.1 mg/kg, ip after 8 hrs (Rvb = 81.56 +/- 13.10 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660405	Diuretic activity in normotensive Wistar rat assessed as urine pH at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of amiloride (Rvb = 6.14 to 6.21 No_unit)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660423	Diuretic activity in normotensive Wistar rat assessed as urinary sodium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of atropine (Rvb = 61.82 to 80.81 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660360	Diuretic activity in normotensive Wistar rat assessed as urine pH at 0.01 mg/kg, po administered via gavage after 8 hrs (Rvb = 6.14 to 6.21 No_unit)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660447	Diuretic activity in normotensive Wistar rat assessed as urinary calcium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of atropine (Rvb = 5.93 to 6.87 mg/dl)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660493	Antioxidant activity assessed as DPPH radical scavenging activity at 100 to 1000 ug/ml after 5 mins	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660440	Diuretic activity in normotensive Wistar rat assessed as urinary chloride excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of L-NAME (Rvb = 135.10 to 143.70 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID357261	Induction of DNA cleavage assessed as relaxation of supercoiled plasmid DNA at > 1 mM in presence of Cu2+ by cell free assay	2002	Journal of natural products, Dec, Volume: 65, Issue:12	DNA-damaging agents from Crypteronia paniculata.
AID1660475	Toxicity in spontaneous hypertensive Wistar rat assessed as changes in plasma calcium level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID551196	Inhibition of human HH/Gli1-mediated transcriptional activity in tetracycline-treated human HaCaT cells treated after 12 hrs of tetracycline addition by luciferase reporter gene assay	2011	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2	New Hedgehog/GLI signaling inhibitors from Excoecaria agallocha.
AID1660369	Diuretic activity in normotensive Wistar rat assessed as urine conductivity at 1 mg/kg, po administered via gavage after 8 hrs (Rvb = 19.54 +/- 0.98 mS/cm)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660432	Diuretic activity in normotensive Wistar rat assessed as urinary potassium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of L-NAME (Rvb = 22.39 to 24.21 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660392	Diuretic activity in normotensive Wistar rat assessed as urinary chloride excretion at 0.1 mg/kg, ip administered via gavage after 8 hrs (Rvb = 103.30 +/- 10.25 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660429	Diuretic activity in normotensive Wistar rat assessed as urinary potassium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of amiloride (Rvb = 22.39 to 24.21 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660444	Diuretic activity in normotensive Wistar rat assessed as urinary calcium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of furosemide (Rvb = 5.93 to 6.87 mg/dl)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1617255	Cytotoxicity against nutrient-rich DMEM cultured human PANC1 cells at PC50 incubated for 24 hrs by WST-8 assay
AID1660476	Toxicity in normotensive Wistar rat assessed as changes in plasma AST level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1186051	Retention time of the compound by UPLC analysis	2014	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17	Phytochemical analysis and antileukemic activity of polyphenolic constituents of Toona sinensis.
AID1660443	Diuretic activity in normotensive Wistar rat assessed as urinary calcium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of hydrochlorothiazide (Rvb = 5.93 to 6.87 mg/dl)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1376888	Antimicrobial activity against Bacillus cereus DSM 4313 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter)
AID1660399	Diuretic activity in normotensive Wistar rat assessed as urinary calcium excretion at 0.1 mg/kg, ip administered via gavage after 8 hrs (Rvb = 5.28 +/- 0.09 mg/dl)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660362	Diuretic activity in normotensive Wistar rat assessed as urine pH at 1 mg/kg, po administered via gavage after 8 hrs (Rvb = 6.14 to 6.21 No_unit)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660397	Diuretic activity in normotensive Wistar rat assessed as urinary calcium excretion at 1 mg/kg, po administered via gavage after 8 hrs (Rvb = 5.93 to 6.87 mg/dl)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660486	Toxicity in normotensive Wistar rat assessed as changes in urea level in urine at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660363	Diuretic activity in normotensive Wistar rat assessed as urine pH at 0.01 mg/kg, ip after 8 hrs (Rvb = 6.05 +/- 0.22 No_unit)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660367	Diuretic activity in normotensive Wistar rat assessed as urine conductivity at 0.01 mg/kg, po administered via gavage after 8 hrs (Rvb = 19.54 +/- 0.98 mS/cm)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660412	Diuretic activity in normotensive Wistar rat assessed as urine conductivity at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of furosemide (Rvb = 19.54 +/- 0.98 mS/cm)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660379	Diuretic activity in normotensive Wistar rat assessed as urinary sodium excretion at 1 mg/kg, ip after 8 hrs (Rvb = 81.56 +/- 13.10 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660494	Renal protective activity in spontaneous hypertensive Wistar rat assessed as reduction in hypertension-induced glomerular size at 0.1 mg/kg, po administered via gavage for 7 days by hematoxylin and eosin staining based microscopic analysis	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID357260	Induction of DNA cleavage assessed as relaxation of supercoiled plasmid DNA at > 1 mM by cell free assay	2002	Journal of natural products, Dec, Volume: 65, Issue:12	DNA-damaging agents from Crypteronia paniculata.
AID1660509	Anti-urolithic activity in synthetic urine assessed as decrease in absorbance at 0.1 mg/mL after 60 mins relative to control	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660478	Toxicity in normotensive Wistar rat assessed as changes in plasma ALT level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1617250	Anti-austerity activity against nutrient-deprived human PANC1 cells assessed as cell death incubated for 24 hrs by WST-8 assay
AID1193988	Inhibition of LPS-induced IL-12 p40 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Chemical constituents from Kandelia candel with their inhibitory effects on pro-inflammatory cytokines production in LPS-stimulated bone marrow-derived dendritic cells (BMDCs).
AID1660479	Toxicity in spontaneous hypertensive Wistar rat assessed as changes in plasma ALT level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1193990	Inhibition of LPS-induced TNF-alpha production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Chemical constituents from Kandelia candel with their inhibitory effects on pro-inflammatory cytokines production in LPS-stimulated bone marrow-derived dendritic cells (BMDCs).
AID1660413	Diuretic activity in normotensive Wistar rat assessed as urine conductivity at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of amiloride (Rvb = 19.54 +/- 0.98 mS/cm)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660391	Diuretic activity in normotensive Wistar rat assessed as urinary chloride excretion at 0.01 mg/kg, ip administered via gavage after 8 hrs (Rvb = 103.30 +/- 10.25 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660480	Toxicity in normotensive Wistar rat assessed as changes in plasma uric acid level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660474	Toxicity in normotensive Wistar rat assessed as changes in plasma calcium level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660449	Diuretic activity in normotensive Wistar rat assessed as increase in urine volume at 0.1 mg/kg, po administered via gavage for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660370	Diuretic activity in normotensive Wistar rat assessed as urine conductivity at 0.01 mg/kg, ip after 8 hrs (Rvb = 24.87 +/- 0.54 mS/cm)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID310105	Antioxidant activity assessed as superoxide radical anion scavenging activity at 0.5 mg/ml by hypoxanthine NBT method	2007	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 17, Issue:22	A novel flavonoid from Lespedeza virgata (Thunb.) DC.: structural elucidation and antioxidative activity.
AID1660456	Diuretic activity in spontaneous hypertensive Wistar rat assessed as increase in urinary chloride excretion at 0.1 mg/kg, po administered via gavage for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660376	Diuretic activity in normotensive Wistar rat assessed as urinary sodium excretion at 1 mg/kg, po administered via gavage after 8 hrs (Rvb = 61.82 to 80.81 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660483	Toxicity in spontaneous hypertensive Wistar rat assessed as changes in plasma nitrite acid level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660435	Diuretic activity in normotensive Wistar rat assessed as urinary chloride excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of hydrochlorothiazide (Rvb = 135.10 to 143.70 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660454	Diuretic activity in normotensive Wistar rat assessed as increase in urinary chloride excretion at 0.1 mg/kg, po administered via gavage for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660381	Diuretic activity in normotensive Wistar rat assessed as urinary potassium excretion at 0.01 mg/kg, po administered via gavage after 8 hrs (Rvb = 22.39 to 24.21 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660481	Toxicity in spontaneous hypertensive Wistar rat assessed as changes in plasma uric acid level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660487	Toxicity in spontaneous hypertensive Wistar rat assessed as changes in urea level in urine at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660471	Toxicity in spontaneous hypertensive Wistar rat assessed as changes in plasma potassium level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660403	Diuretic activity in normotensive Wistar rat assessed as urine pH at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of hydrochlorothiazide (Rvb = 6.14 to 6.21 No_unit)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660455	Diuretic activity in normotensive Wistar rat assessed as decrease in urinary calcium excretion at 0.1 mg/kg, po administered via gavage for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660446	Diuretic activity in normotensive Wistar rat assessed as urinary calcium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of indomethacin (Rvb = 5.93 to 6.87 mg/dl)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660488	Cardioprotective activity in spontaneous hypertensive Wistar rat assessed as effect on heart weight at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1376873	Antioxidant activity in human plasma assessed as inhibition of H2O2/Fe2+-induced lipid peroxidation at 10 uM after 30 mins by TBARS assay relative to control
AID1660438	Diuretic activity in normotensive Wistar rat assessed as urinary chloride excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of indomethacin (Rvb = 135.10 to 143.70 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660364	Diuretic activity in normotensive Wistar rat assessed as urine pH at 0.1 mg/kg, ip after 8 hrs (Rvb = 6.05 +/- 0.22 No_unit)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660501	Anti-urolithic activity in spontaneous hypertensive Wistar rats assessed as reduction in CaOx crystal formation in cumulative urine at 0.1 mg/kg, po administered via gavage in presence of sodium oxalate by Neubauer counting chamber method relative to cont	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660414	Diuretic activity in normotensive Wistar rat assessed as urine conductivity at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of indomethacin (Rvb = 19.54 +/- 0.98 mS/cm)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660495	Renal protective activity in spontaneous hypertensive Wistar rat assessed as reduction in hypertension-induced Bowman's capsule thickening at 0.1 mg/kg, po administered via gavage for 7 days by hematoxylin and eosin staining based microscopic analysis	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660404	Diuretic activity in normotensive Wistar rat assessed as urine pH at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of furosemide (Rvb = 6.14 to 6.21 No_unit)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660430	Diuretic activity in normotensive Wistar rat assessed as urinary potassium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of indomethacin (Rvb = 22.39 to 24.21 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660459	Diuretic activity in spontaneous hypertensive Wistar rat assessed as effect on urinary potassium excretion at 0.1 mg/kg, po administered via gavage for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660361	Diuretic activity in normotensive Wistar rat assessed as urine pH at 0.1 mg/kg, po administered via gavage after 8 hrs (Rvb = 6.14 to 6.21 No_unit)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660396	Diuretic activity in normotensive Wistar rat assessed as urinary calcium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs (Rvb = 5.93 to 6.87 mg/dl)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660411	Diuretic activity in normotensive Wistar rat assessed as urine conductivity at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of hydrochlorothiazide (Rvb = 19.54 +/- 0.98 mS/cm)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660352	Diuretic activity in normotensive Wistar rat assessed as increase in urine volume excretion at 1 mg/kg, ip a after 6 hr	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660450	Diuretic activity in spontaneous hypertensive Wistar rat assessed as increase in urine volume at 0.1 mg/kg, po administered via gavage for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1766076	Inhibition of preadipocyte differentiation in mouse 3T3-L1 cells assessed as lipid droplet accumulation at 100 uM incubated for 8 days by Oil Red O staining method relative to untreated control	2021	Bioorganic & medicinal chemistry letters, 10-01, Volume: 49	Phytochemicals from the flowers of Prunus persica (L.) Batsch: Anti-adipogenic effect of mandelamide on 3T3-L1 preadipocytes.
AID1660470	Toxicity in normotensive Wistar rat assessed as changes in plasma potassium level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660400	Diuretic activity in normotensive Wistar rat assessed as urinary calcium excretion at 1 mg/kg, ip administered via gavage after 8 hrs (Rvb = 5.28 +/- 0.09 mg/dl)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1193989	Inhibition of LPS-induced IL-6 production in wild-type C57BL/6 mouse BMDC pretreated with compound for 1 hr before LPS treatment measured 16 hrs by ELISA	2015	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 25, Issue:7	Chemical constituents from Kandelia candel with their inhibitory effects on pro-inflammatory cytokines production in LPS-stimulated bone marrow-derived dendritic cells (BMDCs).
AID1660422	Diuretic activity in normotensive Wistar rat assessed as urinary sodium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of indomethacin (Rvb = 61.82 to 80.81 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660398	Diuretic activity in normotensive Wistar rat assessed as urinary calcium excretion at 0.01 mg/kg, ip administered via gavage after 8 hrs (Rvb = 5.28 +/- 0.09 mg/dl)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1186044	Cytotoxicity against human HL60 cells assessed as cell survival at 50 uM after 72 hrs by CCK8 assay	2014	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 24, Issue:17	Phytochemical analysis and antileukemic activity of polyphenolic constituents of Toona sinensis.
AID402936	Inhibition of human CYP3A4 by radiometric assay	2004	Journal of natural products, Jul, Volume: 67, Issue:7	Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities.
AID1660448	Diuretic activity in normotensive Wistar rat assessed as urinary calcium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of L-NAME (Rvb = 5.93 to 6.87 mg/dl)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660477	Toxicity in spontaneous hypertensive Wistar rat assessed as changes in plasma AST level at 0.1 mg/kg, po administered for 7 days	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660389	Diuretic activity in normotensive Wistar rat assessed as urinary chloride excretion at 0.1 mg/kg, po administered via gavage after 8 hrs (Rvb = 135.10 to 143.70 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660375	Diuretic activity in normotensive Wistar rat assessed as urinary sodium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs (Rvb = 61.82 to 80.81 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660408	Diuretic activity in normotensive Wistar rat assessed as urine pH at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of L-NAME (Rvb = 6.14 to 6.21 No_unit)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660421	Diuretic activity in normotensive Wistar rat assessed as urinary sodium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of amiloride (Rvb = 61.82 to 80.81 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660437	Diuretic activity in normotensive Wistar rat assessed as urinary chloride excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of amiloride (Rvb = 135.10 to 143.70 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID357258	DNA damaging activity against RAD52 transformed Saccharomyces cerevisiae in galactose minimal medium after 41 hrs	2002	Journal of natural products, Dec, Volume: 65, Issue:12	DNA-damaging agents from Crypteronia paniculata.
AID1660431	Diuretic activity in normotensive Wistar rat assessed as urinary potassium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of atropine (Rvb = 22.39 to 24.21 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660490	In vivo antioxidant activity in Wistar rat model of hypertension-induced oxidative stress assessed as reduction in nitrite level in renal tissue at 0.1 mg/kg, po administered via gavage for 7 days by Griess reagent based assay	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660505	Anti-urolithic activity in synthetic urine assessed as reduction in CaOx crystal formation at 0.1 mg/mL in presence of sodium oxalate after 60 mins by Neubauer counting chamber method relative to control	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660395	Diuretic activity in normotensive Wistar rat assessed as urinary calcium excretion at 0.01 mg/kg, po administered via gavage after 8 hrs (Rvb = 5.93 to 6.87 mg/dl)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660420	Diuretic activity in normotensive Wistar rat assessed as urinary sodium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of furosemide (Rvb = 61.82 to 80.81 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID344828	Inhibition of NADPH oxidase in LPS-induced mouse BV2 cells assessed as NOX-dependent ROS production at 50 uM	2008	Bioorganic & medicinal chemistry, Nov-15, Volume: 16, Issue:22	New diterpenoids and the bioactivity of Erythrophleum fordii.
AID357257	DNA damaging activity against RAD52 transformed Saccharomyces cerevisiae in glucose minimal medium after 41 hrs	2002	Journal of natural products, Dec, Volume: 65, Issue:12	DNA-damaging agents from Crypteronia paniculata.
AID1660388	Diuretic activity in normotensive Wistar rat assessed as urinary chloride excretion at 0.01 mg/kg, po administered via gavage after 8 hrs (Rvb = 135.10 to 143.70 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1376890	Antimicrobial activity against Staphylococcus aureus DSM 25923 assessed as growth inhibition at 40 ug per disc after 24 to 48 hrs (Rvb = 0 millimeter)
AID1660393	Diuretic activity in normotensive Wistar rat assessed as urinary chloride excretion at 1 mg/kg, ip administered via gavage after 8 hrs (Rvb = 103.30 +/- 10.25 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
AID1660428	Diuretic activity in normotensive Wistar rat assessed as urinary potassium excretion at 0.1 mg/kg, po administered via gavage after 8 hrs in presence of furosemide (Rvb = 22.39 to 24.21 mmol/L)	2020	Journal of natural products, 06-26, Volume: 83, Issue:6	Diuretic and Renal Protective Effect of Kaempferol 3-
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (3.03)	18.2507
2000's	13 (19.70)	29.6817
2010's	39 (59.09)	24.3611
2020's	12 (18.18)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	66 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
protocatechuic acid protocatechuic acid: RN given refers to parent cpd; structure. 3,4-dihydroxybenzoic acid : A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.	2.11	1	catechols; dihydroxybenzoic acid	antineoplastic agent; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor; human xenobiotic metabolite; plant metabolite
4-hydroxybenzoic acid 4-hydroxybenzoic acid : A monohydroxybenzoic acid that is benzoic acid carrying a hydroxy substituent at C-4 of the benzene ring.	2.02	1	monohydroxybenzoic acid	algal metabolite; plant metabolite
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2.25	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
gallic acid gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.	3.2	5	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite
formaldehyde paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy	2.11	1	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
indoleacetic acid indoleacetic acid: RN given refers to unlabeled parent cpd; structure in Merck Index, 9th ed, #4841. auxin : Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow").. indole-3-acetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group.	2.17	1	indole-3-acetic acids; monocarboxylic acid	auxin; human metabolite; mouse metabolite; plant hormone; plant metabolite
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2.88	3	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
melatonin [no description available]	2.17	1	acetamides; tryptamines	anticonvulsant; central nervous system depressant; geroprotector; hormone; human metabolite; immunological adjuvant; mouse metabolite; radical scavenger
n-acetylserotonin N-acetylserotonin : An N-acylserotonin resulting from the formal condensation of the primary amino group of serotonin with the carboxy group of acetic acid.	2.17	1	acetamides; N-acylserotonin; phenols	antioxidant; human metabolite; mouse metabolite; tropomyosin-related kinase B receptor agonist
naringenin [no description available]	2.17	1	4'-hydroxyflavanones; trihydroxyflavanone
phenethylamine phenethylamine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7016. 2-phenylethylamine : A phenylethylamine having the phenyl substituent at the 2-position.	2.17	1	alkaloid; aralkylamine; phenylethylamine	Escherichia coli metabolite; human metabolite; mouse metabolite
taurine [no description available]	2.11	1	amino sulfonic acid; zwitterion	antioxidant; Escherichia coli metabolite; glycine receptor agonist; human metabolite; mouse metabolite; nutrient; radical scavenger; Saccharomyces cerevisiae metabolite
tryptamine [no description available]	2.17	1	aminoalkylindole; aralkylamino compound; indole alkaloid; tryptamines	human metabolite; mouse metabolite; plant metabolite
5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate [no description available]	2.17	1	catechin
hydroxyindoleacetic acid (5-hydroxyindol-3-yl)acetic acid : A member of the class of indole-3-acetic acids that is indole-3-acetic acid substituted by a hydroxy group at C-5.	2.17	1	indole-3-acetic acids	drug metabolite; human metabolite; mouse metabolite
5-methoxytryptamine 5-Methoxytryptamine: Serotonin derivative proposed as potentiator for hypnotics and sedatives.. 5-methoxytryptamine : A member of the class of tryptamines that is the methyl ether derivative of serotonin.	2.17	1	aromatic ether; primary amino compound; tryptamines	5-hydroxytryptamine 2A receptor agonist; 5-hydroxytryptamine 2B receptor agonist; 5-hydroxytryptamine 2C receptor agonist; antioxidant; cardioprotective agent; human metabolite; mouse metabolite; neuroprotective agent; radiation protective agent; serotonergic agonist
7,8-dihydroxyflavone 7,8-dihydroxyflavone : A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A dihydroxyflavone that is flavone substituted by hydroxy groups at positions 7 and 8. A naturally occurring flavonoid produced by several plants, including the weed Tridax procumbens (coalbuttons or tridax daisy) and the tree Godmania aesculifolia, In animal models, it has shown efficacy against several diseases of the nervous system, including Alzheimer's, Parkinson's, and Huntington's.	2.17	1	dihydroxyflavone	antidepressant; antineoplastic agent; antioxidant; plant metabolite; tropomyosin-related kinase B receptor agonist
4',7-dihydroxyflavanone [no description available]	2.17	1	4'-hydroxyflavanones; dihydroxyflavanone; polyphenol	Brassica napus metabolite; fungal xenobiotic metabolite
diphenyleneiodonium diphenyleneiodonium: structure in first source; NADPH oxidase inhibitor. dibenziodolium : An organic cation that is fluorene in which the methylene group is replaced by a positively charged iodine.	2.04	1	organic cation
furosemide Furosemide: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for EDEMA and chronic RENAL INSUFFICIENCY.. furosemide : A chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.	2.25	1	chlorobenzoic acid; furans; sulfonamide	environmental contaminant; loop diuretic; xenobiotic
harmaline Harmaline: A beta-carboline alkaloid isolated from seeds of PEGANUM.. harmaline : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7 and has been reduced across the 3,4 bond.	2.17	1	harmala alkaloid	oneirogen
hydrochlorothiazide Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.. hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.	2.25	1	benzothiadiazine; organochlorine compound; sulfonamide	antihypertensive agent; diuretic; environmental contaminant; xenobiotic
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	2.04	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
ketoconazole 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.	2.02	1	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine
methyl methanesulfonate [no description available]	2.31	1	methanesulfonate ester	alkylating agent; apoptosis inducer; carcinogenic agent; genotoxin; mutagen
octopamine Octopamine: An alpha-adrenergic sympathomimetic amine, biosynthesized from tyramine in the CNS and platelets and also in invertebrate nervous systems. It is used to treat hypotension and as a cardiotonic. The natural D(-) form is more potent than the L(+) form in producing cardiovascular adrenergic responses. It is also a neurotransmitter in some invertebrates.. octopamine : A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates.	2.17	1	phenylethanolamines; tyramines	neurotransmitter
oxybenzone oxybenzone : A hydroxybenzophenone that is benzophenone which is substituted at the 2- and 4-positions of one of the benzene rings by hydroxy and methoxy groups respectively.	2.31	1	hydroxybenzophenone; monomethoxybenzene	dermatologic drug; environmental contaminant; protective agent; ultraviolet filter; xenobiotic
4-aminobenzoic acid para-Aminobenzoates: Benzoic acids, salts, or esters that contain an amino group attached to carbon number 4 of the benzene ring structure.. 4-aminobenzoate : An aromatic amino-acid anion that is the conjugate base of 4-aminobenzoic acid.	2.31	1	aminobenzoate; aromatic amino-acid anion	Escherichia coli metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
tyramine [no description available]	2.55	2	monoamine molecular messenger; primary amino compound; tyramines	EC 3.1.1.8 (cholinesterase) inhibitor; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter
uridine [no description available]	2.31	1	uridines	drug metabolite; fundamental metabolite; human metabolite
tyrosine Tyrosine: A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.. tyrosine : An alpha-amino acid that is phenylalanine bearing a hydroxy substituent at position 4 on the phenyl ring.	2.1	1	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical
n-methyltryptamine N-methyltryptamine: RN given refers to parent cpd	2.17	1	tryptamine alkaloid; tryptamines	metabolite
tert-butylhydroperoxide tert-Butylhydroperoxide: A direct-acting oxidative stress-inducing agent used to examine the effects of oxidant stress on Ca(2+)-dependent signal transduction in vascular endothelial cells. It is also used as a catalyst in polymerization reactions and to introduce peroxy groups into organic molecules.. tert-butyl hydroperoxide : An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes.	2.08	1	alkyl hydroperoxide	antibacterial agent; oxidising agent
quinic acid (-)-quinic acid : The (-)-enantiomer of quinic acid.	2.25	1
gramine gramine : An aminoalkylindole that is indole carrying a dimethylaminomethyl substituent at postion 3.	2.17	1	aminoalkylindole; indole alkaloid; tertiary amino compound	antibacterial agent; antiviral agent; plant metabolite; serotonergic antagonist
xanthenes Xanthenes: Compounds with three aromatic rings in linear arrangement with an OXYGEN in the center ring.	2.03	1	xanthene
propylparaben Parabens: Methyl, propyl, butyl, and ethyl esters of p-hydroxybenzoic acid. They have been approved by the FDA as antimicrobial agents for foods and pharmaceuticals. (From Hawley's Condensed Chemical Dictionary, 11th ed, p872)	2.02	1	benzoate ester; paraben; phenols	antifungal agent; antimicrobial agent
methyl gallate methyl gallate: has both immunosuppressive and phytogenic antineoplastic activities; isolated from Acer saccharinum. methyl 3,4,5-trihydroxybenzoate : A gallate ester obtained by the formal condensation of gallic acid with methanol. It exhibits anti-oxidant, anti-tumor, anti-microbial and anti-inflammatory properties.	1.99	1	gallate ester	anti-inflammatory agent; antioxidant; plant metabolite
ethyl acetate ethyl acetate : The acetate ester formed between acetic acid and ethanol.	2.08	1	acetate ester; ethyl ester; volatile organic compound	EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor; metabolite; polar aprotic solvent; Saccharomyces cerevisiae metabolite
yohimbine Yohimbine: A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.. yohimbine : An indole alkaloid with alpha2-adrenoceptor antagonist activity. It is produced by Corynanthe johimbe and Rauwolfia serpentina.	2.17	1	methyl 17-hydroxy-20xi-yohimban-16-carboxylate	alpha-adrenergic antagonist; dopamine receptor D2 antagonist; serotonergic antagonist
catechin Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.. catechin : Members of the class of hydroxyflavan that have a flavan-3-ol skeleton and its substituted derivatives.. rac-catechin : A racemate comprising equimolar amounts of (+)- and (-)-catechin. (+)-catechin : The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.	2.51	2	catechin	antioxidant; plant metabolite
methyl-4-tyramine methyl-4-tyramine: found in barley malt; RN given refers to parent cpd; structure given in first source	2.17	1	tyramines	mouse metabolite
aloe emodin aloe emodin: structure distinct from emodin; this does not mean emodin from aloe. Aloe emodin : A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.	2.15	1	aromatic primary alcohol; dihydroxyanthraquinone	antineoplastic agent; plant metabolite
flavone flavone: RN given refers to unlabeled cpd; structure given in first source. flavone : The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.	2.13	1	flavones	metabolite; nematicide
3-hydroxyflavone 3-hydroxyflavone: structure given in first source. flavonol : A monohydroxyflavone that is the 3-hydroxy derivative of flavone.	3.07	4	flavonols; monohydroxyflavone
n-methylphenethylamine N-methylphenethylamine: substrate for type A & B monoamine oxidase; RN given refers to parent cpd	2.17	1
ethyl gallate ethyl gallate: used with osmium in procedure for mapping neuronal pathways. ethyl gallate : A gallate ester obtained by the formal condensation of gallic acid with ethanol.	2.1	1	gallate ester	plant metabolite
potassium citrate Potassium Citrate: A powder that dissolves in water, which is administered orally, and is used as a diuretic, expectorant, systemic alkalizer, and electrolyte replenisher.. potassium citrate (anhydrous) : The anhydrous form of the tripotassium salt of citric acid.	2.25	1	potassium salt	diuretic
amiloride Amiloride: A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705). amiloride : A member of the class of pyrazines resulting from the formal monoacylation of guanidine with the carboxy group of 3,5-diamino-6-chloropyrazine-2-carboxylic acid.	2.25	1	aromatic amine; guanidines; organochlorine compound; pyrazines	diuretic; sodium channel blocker
tabersonine [no description available]	2.17	1	alkaloid ester; methyl ester; monoterpenoid indole alkaloid; organic heteropentacyclic compound	antineoplastic agent; metabolite
silver Silver: An element with the atomic symbol Ag, atomic number 47, and atomic weight 107.87. It is a soft metal that is used medically in surgical instruments, dental prostheses, and alloys. Long-continued use of silver salts can lead to a form of poisoning known as ARGYRIA.	2.17	1	copper group element atom; elemental silver	Escherichia coli metabolite
hypochlorous acid Hypochlorous Acid: An oxyacid of chlorine (HClO) containing monovalent chlorine that acts as an oxidizing or reducing agent.. hypochlorous acid : A chlorine oxoacid with formula HOCl; a weak, unstable acid, it is the active form of chlorine in water.	2.11	1	chlorine oxoacid; reactive oxygen species	EC 2.5.1.18 (glutathione transferase) inhibitor; EC 3.1.1.7 (acetylcholinesterase) inhibitor; human metabolite
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	2.11	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
padimate-o padimate-O: active ingredient in sunscreen products	2.31	1	benzoate ester
phenyl acetate phenyl acetate: The ester formed between phenol and acetic acid. Don't confuse with phenylacetic acid derivatives listed under PHENYLACETATES.. phenyl acetate : An acetate ester obtained by the formal condensation of phenol with acetic acid.	2.08	1	benzenes; phenyl acetates
ng-nitroarginine methyl ester NG-Nitroarginine Methyl Ester: A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.	2.04	1	alpha-amino acid ester; L-arginine derivative; methyl ester; N-nitro compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid [no description available]	2.04	1	chromanol; monocarboxylic acid; phenols	antioxidant; ferroptosis inhibitor; neuroprotective agent; radical scavenger; Wnt signalling inhibitor
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	3	4	D-glucopyranose	epitope; mouse metabolite
betulinic acid [no description available]	2.17	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-HIV agent; anti-inflammatory agent; antimalarial; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; plant metabolite
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose pentagalloylglucose: pentahydroxy gallic acid ester of glucose; a phytogenic antineoplastic agent and antibacterial agent. 1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose : A galloyl-beta-D-glucose compound having five galloyl groups in the 1-, 2-, 3-, 4- and 6-positions.	2.44	2	gallate ester; galloyl beta-D-glucose	anti-inflammatory agent; antineoplastic agent; geroprotector; hepatoprotective agent; plant metabolite; radiation protective agent; radical scavenger
epicatechin (-)-epicatechin : A catechin with (2R,3R)-configuration.	2.51	2	catechin; polyphenol	antioxidant
magnolol [no description available]	2.13	1	biphenyls
honokiol [no description available]	2.13	1	biphenyls
maslinic acid (2Alpha,3beta)-2,3-dihydroxyolean-12-en-28-oic acid: from Luehea divaricata and Agrimonia eupatoria	2.17	1	dihydroxy monocarboxylic acid; pentacyclic triterpenoid	anti-inflammatory agent; antineoplastic agent; antioxidant; plant metabolite
friedelin 3-friedelanone: from the stem bark of Irvingia gabonensis; structure in first source. friedelin : A pentacyclic triterpenoid that is perhydropicene which is substituted by an oxo group at position 3 and by methyl groups at the 4, 4a, 6b, 8a, 11, 11, 12b, and 14a-positions (the 4R,4aS,6aS,6bR,8aR,12aR,12bS,14aS,14bS-enantiomer). It is the major triterpenoid constituent of cork.	2.04	1	cyclic terpene ketone; pentacyclic triterpenoid	anti-inflammatory drug; antipyretic; non-narcotic analgesic; plant metabolite
taraxerol taraxerol: structure. taraxerol : A pentacyclic triterpenoid that is oleanan-3-ol lacking the methyl group at position 14, with an alpha-methyl substituent at position 13 and a double bond between positions 14 and 15.	2.04	1	pentacyclic triterpenoid; secondary alcohol	metabolite
beta-amyrin acetate [no description available]	2.04	1	triterpenoid
taraxerone taraxerone: structure	2.04	1	scalarane sesterterpenoid	metabolite
prunin protein, prunus prunin protein, Prunus: a legumin-like type of globulin; structure given in first source. naringenin 7-O-beta-D-glucoside : A flavanone 7-O-beta-D-glucoside that is (S)-naringenin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.31	1	(2S)-flavan-4-one; 4'-hydroxyflavanones; dihydroxyflavanone; flavanone 7-O-beta-D-glucoside; monosaccharide derivative	antibacterial agent; antilipemic drug; hypoglycemic agent; metabolite
pyrimidine dimers Pyrimidine Dimers: Dimers found in DNA chains damaged by ULTRAVIOLET RAYS. They consist of two adjacent PYRIMIDINE NUCLEOTIDES, usually THYMINE nucleotides, in which the pyrimidine residues are covalently joined by a cyclobutane ring. These dimers block DNA REPLICATION.	2.08	1
quindoline quindoline: a fused indole-quinoline alkaloid from CRYPTOLEPIS sanguinolenta; structure	2.17	1
tryptoline tryptoline: neurotoxic factor that may be involved in development of Parkinson's disease; enzymatic prep from human brain converts tryptamine to tryptoline; RN given refers to parent cpd; structure	2.17	1	beta-carbolines
procyanidin Proanthocyanidins: Dimers and oligomers of flavan-3-ol units (CATECHIN analogs) linked mainly through C4 to C8 bonds to leucoanthocyanidins. They are structurally similar to ANTHOCYANINS but are the result of a different fork in biosynthetic pathways.	4.97	34	proanthocyanidin
pumiliotoxin c pumiliotoxin C: isolated from skin of Dendrobates pumilio (frog); see also records for pumiliotoxin A, pumiliotoxin B & pumiliotoxins	2.17	1
echinuline echinuline: tri-isoprenylated cyclic dipeptide from Aspergillus amstelodami; structure; Rn given refers to (3S-cis)-isomer. echinulin : An indole alkaloid with formula C29H39N3O2. It is a fungal metabolite found in several Aspergillus species.	2.04	1	2,5-diketopiperazines; indole alkaloid; indoles; olefinic compound	Aspergillus metabolite; marine metabolite; plant metabolite
diazaquinomycin a diazaquinomycin A: structure given in first source	2.17	1	quinolone
fraxinellone fraxinellone: structure given in first source; RN given for (3R-cis)-isomer	2.17	1	2-benzofurans
glabridin [no description available]	2.17	1	hydroxyisoflavans	antiplasmodial drug
6-bromo-3-(bromomethyl)-7-methyl-2,3,7-trichloro-1-octene 6-bromo-3-(bromomethyl)-7-methyl-2,3,7-trichloro-1-octene: structure given in first source	2.17	1	monoterpenoid; organobromine compound; organochlorine compound	algal metabolite; antineoplastic agent; marine metabolite
omega-n-methylarginine omega-N-Methylarginine: A competitive inhibitor of nitric oxide synthetase.. N(omega)-methyl-L-arginine : A L-arginine derivative with a N(omega)-methyl substituent.	2.04	1	amino acid zwitterion; arginine derivative; guanidines; L-arginine derivative; non-proteinogenic L-alpha-amino acid
procyanidin b3 procyanidin B3 : A proanthocyanidin consisting of two molecules of (+)-catechin joined by a bond between positions 4 and 8' in alpha-configuration. It can be found in red wine, in barley, in beer, in peach or in Jatropha macrantha, the Huanarpo Macho.	2.1	1	biflavonoid; hydroxyflavan; polyphenol; proanthocyanidin	anti-inflammatory agent; antioxidant; EC 2.3.1.48 (histone acetyltransferase) inhibitor; metabolite
pseudonicotine pseudonicotine: structure. (R)-nicotine : A 3-(1-methylpyrrolidin-2-yl)pyridine in which the chiral centre has R-configuration.	2.17	1	3-(1-methylpyrrolidin-2-yl)pyridine
deferrioxamine e deferrioxamine E: may act as siderophore in Streptomyces. desferrioxamine E : A cyclic hydroxamic acid siderophore that is produced by several bacterial species and exhibits antitumour activity.	2.17	1	cyclic desferrioxamine; cyclic hydroxamic acid; macrocycle	antineoplastic agent; bacterial metabolite; marine metabolite; siderophore
methylinositol methylinositol: from Ebenus haussknechtii; structure in first source. pinitol : A cyclitol ether formed by etherification of the 3-hydroxy group of chiro-inositol. It is plant metabolite isolated from the leaves of Sutherlandia frutescens.. 1D-4-O-methyl-myo-inositol : A member of the class of methyl myo-inositols that is cyclohexane-1,2,3,4,5-pentol substituted by a methoxy group at position 6 (the 1R,2S,3S,4S,5S,6S-isomer).. D-pinitol : The D-enantiomer of pinitol.	2.04	1
4'-hydroxyflavanone 4'-hydroxyflavanone: structure in first source. 4'-hydroxyflavanones : Any hydroxyflavanone having a hydroxy substituent located at position 4'.	2.17	1	4'-hydroxyflavanones; monohydroxyflavanone
sb 203580 [no description available]	2.13	1	imidazoles; monofluorobenzenes; pyridines; sulfoxide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent
sitosterol, (3beta)-isomer Sobatum: tradename; active fraction of Solanum trilobatum; reduces side-effects of radiation-induced toxicity. sitosterol : A member of the class of phytosterols that is stigmast-5-ene substituted by a beta-hydroxy group at position 3.	2.02	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; C29-steroid; phytosterols; stigmastane sterol	anticholesteremic drug; antioxidant; mouse metabolite; plant metabolite; sterol methyltransferase inhibitor
lupeol [no description available]	2.17	1	pentacyclic triterpenoid; secondary alcohol	anti-inflammatory drug; plant metabolite
crinine crinine: structure in first source	2.17	1	alkaloid
naringenin (S)-naringenin : The (S)-enantiomer of naringenin.	2.57	2	(2S)-flavan-4-one; naringenin	expectorant; plant metabolite
1,2,6-tri-o-galloyl-beta-d-glucopyranose 1,2,6-tri-O-galloyl-beta-D-glucopyranose: from Terminalia chebula fruits, effective against multidrug-resistant uropathogens; structure in first source. 1,2,6-tris-O-galloyl-beta-D-glucose : A galloyl-beta-D-glucose compound having the galloyl groups in the 1-, 2- and 6-positions.	1.99	1	gallate ester; galloyl beta-D-glucose
arbutin hydroquinone O-beta-D-glucopyranoside : A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.	2.05	1	beta-D-glucoside; monosaccharide derivative	Escherichia coli metabolite; plant metabolite
strychnine Strychnine: An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.. strychnine : A monoterpenoid indole alkaloid that is strychnidine bearing a keto substituent at the 10-position.	2.17	1	monoterpenoid indole alkaloid; organic heteroheptacyclic compound	avicide; cholinergic antagonist; glycine receptor antagonist; neurotransmitter agent; rodenticide
quinidine Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.. quinidine : A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.	2.02	1	cinchona alkaloid	alpha-adrenergic antagonist; anti-arrhythmia drug; antimalarial; drug allergen; EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor; EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor; muscarinic antagonist; P450 inhibitor; potassium channel blocker; sodium channel blocker
micheliolide micheliolide: has antineoplastic activity; structure in first source	2.17	1	sesquiterpene lactone
tellimagrandin i tellimagrandin I: isolated from Filipendula palmata; RN given for (D)-isomer	2.15	1	tannin
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	2.13	1
acanthoside b acanthoside B: isolated from the herb Huanghuaren; RN given refers to (1S-(1alpha,3aalpha,4alpha,6aalpha))-isomer	2.11	1	beta-D-glucoside	metabolite
pancracine pancracine: structure in first source	2.17	1	isoquinoline alkaloid fundamental parent; isoquinoline alkaloid
ferulic acid ferulate : A monocarboxylic acid anion obtained by the deprotonation of the carboxy group of ferulic acid.	2.63	2	ferulic acids	anti-inflammatory agent; antioxidant; apoptosis inhibitor; cardioprotective agent; MALDI matrix material; plant metabolite
glycosides [no description available]	4.21	16
piperine piperine : A N-acylpiperidine that is piperidine substituted by a (1E,3E)-1-(1,3-benzodioxol-5-yl)-5-oxopenta-1,3-dien-5-yl group at the nitrogen atom. It is an alkaloid isolated from the plant Piper nigrum.	2.17	1	benzodioxoles; N-acylpiperidine; piperidine alkaloid; tertiary carboxamide	food component; human blood serum metabolite; NF-kappaB inhibitor; plant metabolite
trichodermamide b trichodermamide B: from cultures of the marine-derived fungus Trichoderma virens; structure in first source	2.17	1
caffeic acid trans-caffeic acid : The trans-isomer of caffeic acid.	2.11	1	caffeic acid	geroprotector; mouse metabolite
methyl caffeate methyl caffeate: from plant Gaillardia pulchella. methyl caffeate : An alkyl caffeate ester formed by the formal condensation of caffeic acid with methyl alcohol.	2.31	1	alkyl caffeate ester; methyl ester
chlorogenic acid caffeoylquinic acid: Antiviral Agent; structure in first source. chlorogenate : A monocarboxylic acid anion that is the conjugate base of chlorogenic acid; major species at pH 7.3.	2.58	2	cinnamate ester; tannin	food component; plant metabolite
1,1-diphenyl-2-picrylhydrazyl 1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)	2.51	2
helvolic acid helvolic acid: structure. helvolic acid : A steroid C-21 acid having a 29-nordammarane skeleton substituted with an acetoxy group at C-16 and oxo groups at C-3 and -7, with double bonds at C-1, -17(20) and -24.	2.17	1	3-oxo-Delta(1) steroid; acetate ester; monocarboxylic acid; steroid acid	antibacterial agent; fungal metabolite; mycotoxin
mitragynine [no description available]	2.17	1	monoterpenoid indole alkaloid
paynantheine paynantheine: structure in first source	2.17	1
chimonanthine chimonanthine: structure in first source. chimonanthine : A ring assembly that is 2,2',3,3',8,8',8a,8a'-octahydro-1H,1'H-3a,3a'-bipyrrolo[2,3-b]indole substituted by methyl groups at positions 1 and 1'.	2.17	1	chimonanthine
ovalbumin Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.	2.52	2
3-deoxyisoochracinic acid 3-deoxyisoochracinic acid: structure in first source	2.17	1
quercetin [no description available]	4.61	24	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
dinoprostone prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.	2.46	2	prostaglandins E	human metabolite; mouse metabolite; oxytocic
apigenin Chamomile: Common name for several daisy-like plants (MATRICARIA; TRIPLEUROSPERMUM; ANTHEMIS; CHAMAEMELUM) native to Europe and Western Asia, now naturalized in the United States and Australia.	2.13	1	trihydroxyflavone	antineoplastic agent; metabolite
luteolin [no description available]	2.13	1	3'-hydroxyflavonoid; tetrahydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antineoplastic agent; apoptosis inducer; c-Jun N-terminal kinase inhibitor; EC 2.3.1.85 (fatty acid synthase) inhibitor; immunomodulator; nephroprotective agent; plant metabolite; radical scavenger; vascular endothelial growth factor receptor antagonist
quercitrin [no description available]	4.59	24	alpha-L-rhamnoside; monosaccharide derivative; quercetin O-glycoside; tetrahydroxyflavone	antileishmanial agent; antioxidant; EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.14.18.1 (tyrosinase) inhibitor; plant metabolite
luteolin-7-glucoside luteolin-7-glucoside: has both antiasthmatic and antineoplastic activities; has 3C protease inhibitory activity; isolated from Ligustrum lucidum. luteolin 7-O-beta-D-glucoside : A glycosyloxyflavone that is luteolin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.44	2	beta-D-glucoside; glycosyloxyflavone; monosaccharide derivative; trihydroxyflavone	antioxidant; plant metabolite
chrysoeriol chrysoeriol: isolated from leaves of Eurya japonica & E. emarginata. 4',5,7-trihydroxy-3'-methoxyflavone : The 3'-O-methyl derivative of luteolin.	1.98	1	monomethoxyflavone; trihydroxyflavone	antineoplastic agent; antioxidant; metabolite
apigetrin apigetrin: structure given in first source. apigenin 7-O-beta-D-glucoside : A glycosyloxyflavone that is apigenin substituted by a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	1.98	1	beta-D-glucoside; dihydroxyflavone; glycosyloxyflavone; monosaccharide derivative	antibacterial agent; metabolite; non-steroidal anti-inflammatory drug
quercetin 3-o-glucopyranoside quercetin 3-O-glucopyranoside: structure in first source. quercetin 3-O-beta-D-glucopyranoside : A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells	2.11	1	beta-D-glucoside; monosaccharide derivative; quercetin O-glucoside; tetrahydroxyflavone	antineoplastic agent; antioxidant; antipruritic drug; bone density conservation agent; geroprotector; histamine antagonist; osteogenesis regulator; plant metabolite
rutin Hydroxyethylrutoside: Monohydroxyethyl derivative of rutin. Peripheral circulation stimulant used in treatment of venous disorders.	3.59	8	disaccharide derivative; quercetin O-glucoside; rutinoside; tetrahydroxyflavone	antioxidant; metabolite
3-methylkaempferol 3-methylkaempferol: structure in first source. 3-methoxyapigenin : A trihydroxyflavone that is apigenin substituted by a methoxy group at position 3.	2.02	1	monomethoxyflavone; trihydroxyflavone	plant metabolite
kaempferol [no description available]	3.69	9	7-hydroxyflavonol; flavonols; tetrahydroxyflavone	antibacterial agent; geroprotector; human blood serum metabolite; human urinary metabolite; human xenobiotic metabolite; plant metabolite
harmine Harmine: Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic PARKINSON DISEASE in the 1920's.. harmine : A harmala alkaloid in which the harman skeleton is methoxy-substituted at C-7.	2.17	1	harmala alkaloid	anti-HIV agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; metabolite
spinasterol spinasterol: RN given refers to alpha-spinasterol ((3beta,5alpha,22E)-isomer)	2.04	1	steroid
baicalein [no description available]	2.17	1	trihydroxyflavone	angiogenesis inhibitor; anti-inflammatory agent; antibacterial agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 4.1.1.17 (ornithine decarboxylase) inhibitor; ferroptosis inhibitor; geroprotector; hormone antagonist; plant metabolite; prostaglandin antagonist; radical scavenger
fisetin [no description available]	2.17	1	3'-hydroxyflavonoid; 7-hydroxyflavonol; tetrahydroxyflavone	anti-inflammatory agent; antioxidant; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; metabolite; plant metabolite
hyperoside quercetin 3-O-beta-D-galactopyranoside : A quercetin O-glycoside that is quercetin with a beta-D-galactosyl residue attached at position 3. Isolated from Artemisia capillaris, it exhibits hepatoprotective activity.	3.18	5	beta-D-galactoside; monosaccharide derivative; quercetin O-glycoside; tetrahydroxyflavone	hepatoprotective agent; plant metabolite
myricetin [no description available]	2.15	1	7-hydroxyflavonol; hexahydroxyflavone	antineoplastic agent; antioxidant; cyclooxygenase 1 inhibitor; food component; geroprotector; hypoglycemic agent; plant metabolite
wogonin wogonin: structure in first source. wogonin : A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.	2.17	1	dihydroxyflavone; monomethoxyflavone	angiogenesis inhibitor; antineoplastic agent; cyclooxygenase 2 inhibitor; plant metabolite
rosmarinic acid rosmarinic acid: RN given refers to parent cpd; promote OT project. (R)-rosmarinic acid : A stereoisomer of rosmarinic acid having (R)-configuration.. rosmarinic acid : The 1-carboxy-2-(2,4-dihydroxyphenyl)ethyl ester of trans-caffeic acid.	1.98	1	rosmarinic acid	geroprotector; plant metabolite
shogaol shogaol: from ginger, ZINGIBER OFFICINALE; less mutagenic than GINGEROL; structure given in first source	2.02	1	enone; monomethoxybenzene; phenols
ellagic acid [no description available]	2.01	1	catechols; cyclic ketone; lactone; organic heterotetracyclic compound; polyphenol	antioxidant; EC 1.14.18.1 (tyrosinase) inhibitor; EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor; EC 2.4.1.1 (glycogen phosphorylase) inhibitor; EC 2.5.1.18 (glutathione transferase) inhibitor; EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor; EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor; EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; EC 5.99.1.2 (DNA topoisomerase) inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; food additive; fungal metabolite; geroprotector; plant metabolite; skin lightening agent
cerulenin Cerulenin: An epoxydodecadienamide isolated from several species, including ACREMONIUM, Acrocylindrum, and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.. cerulenin : An epoxydodecadienamide isolated from several species, including Acremonium, Acrocylindrum and Helicoceras. It inhibits the biosynthesis of several lipids by interfering with enzyme function.	2.01	1	epoxide; monocarboxylic acid amide	antifungal agent; antiinfective agent; antilipemic drug; antimetabolite; antimicrobial agent; fatty acid synthesis inhibitor
astragalin kaempferol-3-O-glucoside: isolated from the pit of Mahkota dewa; structure in first source. kaempferol 3-O-beta-D-glucoside : A kaempferol O-glucoside in which a glucosyl residue is attached at position 3 of kaempferol via a beta-glycosidic linkage.	3.21	5	beta-D-glucoside; kaempferol O-glucoside; monosaccharide derivative; trihydroxyflavone	plant metabolite; trypanocidal drug
quercimeritrin quercimeritrin: from Rumex luminiastrum. quercetin 7-O-beta-D-glucoside : A quercetin O-glucoside in which a glucosyl residue is attached at position 7 of quercetin via a beta-glycosidic linkage.	2.03	1	beta-D-glucoside; flavonols; monosaccharide derivative; quercetin O-glucoside; tetrahydroxyflavone	antioxidant; metabolite
cytochalasin b Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.. cytochalasin B : An organic heterotricyclic compound, that is a mycotoxin which is cell permeable an an inhibitor of cytoplasmic division by blocking the formation of contractile microfilaments.	2.17	1	cytochalasin; lactam; lactone; organic heterotricyclic compound	actin polymerisation inhibitor; metabolite; mycotoxin; platelet aggregation inhibitor
isorhamnetin 3-o-glucoside isorhamnetin 3-O-glucoside: from the flowers of Persea gratissima; structure in first source. isorhamnetin 3-O-beta-D-glucopyranoside : A glycosyloxyflavone that is isorhamnetin substituted at position 3 by a beta-D-glucosyl residue.	2.11	1	beta-D-glucoside; glycosyloxyflavone; monomethoxyflavone; monosaccharide derivative; trihydroxyflavone	metabolite
juglanin juglanin: antioxidant from Polygonum aviculare; structure in first source	2.06	1	flavonoids; glycoside
kaempferol-3-o-rutinoside kaempferol-3-O-rutinoside: isolated from the methanolic extract of the whole plants of Diodia teres through repeated silica gel and Sephadex LH-20 column chromatography; structure in first source. kaempferol-3-rutinoside : A kaempferol O-glucoside that is kaempferol attached to a rutinosyl [6-deoxy-alpha-L-mannosyl-(1->6)-beta-D-glucosyl] residue at position 3 via a glycosidic linkage. It has been isolated from the leaves of Solanum campaniforme.	2.99	4	disaccharide derivative; kaempferol O-glucoside; rutinoside; trihydroxyflavone	metabolite; plant metabolite; radical scavenger
ombuine ombuine: from rhizome of Alpinia tonkinensis. ombuin : A dimethoxyflavone that is quercetin in which the hydroxy groups at positions 7 and 4' are replaced by methoxy groups. Isolated from Cyperus teneriffae, it exhibits anti-inflammatory activity.	1.98	1	dimethoxyflavone; flavonols; trihydroxyflavone	anti-inflammatory agent; plant metabolite
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one: isolated from the Chinese herb Scutellariae radix. oroxylin A : A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-6.	2.17	1	dihydroxyflavone; monomethoxyflavone	antineoplastic agent; EC 1.14.13.39 (nitric oxide synthase) inhibitor
ermanin ermanin: from Tanacetum microphyllum; structure given in first source. 3,4'-dimethylkaempferol : A dimethoxyflavone that is kaempferol in which the hydroxy groups at position 3 and 4' have been replaced by methoxy groups. It is a component of bee glue and isolated from several plant species including Tanacetum microphyllum.	2.02	1	dihydroxyflavone; dimethoxyflavone	anti-inflammatory agent; antimycobacterial drug; antineoplastic agent; apoptosis inducer; plant metabolite
lead Lead: A soft, grayish metal with poisonous salts; atomic number 82, atomic weight 207.2, symbol Pb.	2.25	1	carbon group element atom; elemental lead; metal atom	neurotoxin
radicinin radicinin: mold metabolite from plant pathogen Stemphylium radicinum; RN given refers to (2S-(2alpha,3beta,7E))-isomer; structure	2.17	1	aromatic ketone
calycanthine calycanthine: the principal alkaloid of the plant family Calycanthaceae; RN given refers to (4bS)-(4balpha,5alpha,10balpha,11alpha)-isomer. calycanthine : The principal alkaloid of the plant family Calycanthaceae.	2.17	1	aminal; calycanthaceous alkaloid; organonitrogen heterocyclic compound
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid: chromogen in glucose oxidase-peroxidase method for determining serum glucose; used in free radical scavenging assays; structure in first source	2.13	1
zerumbone zerumbone: RN given for (E,E,E)-isomer; structure in first source. zerumbone : A sesquiterpenoid and cyclic ketone that is (1E,4E,8E)-alpha-humulene which is substituted by an oxo group at the carbon atom attached to two double bonds. It is obtained by steam distillation from a type of edible ginger, Zingiber zerumbet Smith, grown particularly in southeast Asia.	2.02	1	cyclic ketone; sesquiterpenoid	anti-inflammatory agent; glioma-associated oncogene inhibitor; plant metabolite
narcissin flavonol narcissin flavonol: flavanol glycoside from Strumpfia maritima; do not confuse with other narcissin in Chemline, an alkaloid (lycorine (NM))	2.11	1	disaccharide derivative; glycosyloxyflavone; monomethoxyflavone; trihydroxyflavone
xanthoepocin Xanthoepocin: an antibiotic from Penicillium simplicissimum IFO5762; structure in first source	2.17	1
lespenefril lespenefril: RN given refers to (L)-isomer. kaempferol 3,7-di-O-alpha-L-rhamnoside : A glycosyloxyflavone that is kaempferol attached to alpha-L-rhamnopyranosyl residues at positions 3 and 7 respectively via glycosidic linkages. It has been isolated from the aerial parts of Vicia faba and Lotus edulis.	2.96	4	alpha-L-rhamnoside; dihydroxyflavone; glycosyloxyflavone; monosaccharide derivative; polyphenol	anti-inflammatory agent; antidepressant; antineoplastic agent; apoptosis inducer; bone density conservation agent; hypoglycemic agent; immunomodulator; plant metabolite
myricetin 3-o-glucuronide myricetin 3-O-glucuronide: from Epilobium angustifolium. myricetin 3-O-glucuronide : A myricetin O-glucuronide that is myricetin with a beta-D-glucosiduronic acid residue attached at the 3-position.	2.15	1	monosaccharide derivative; myricetin O-glucuronide; pentahydroxyflavone	metabolite
herboxidiene herboxidiene: structure in first source; isolated from Streptomyces chromofuscus; a potent and selective herbicide (e.g. inactive against wheat); up-regulates the gene expression of LDL receptor	2.17	1
2''-galloylhyperin 2''-galloylhyperin: isolated from Pyrola calliantha	1.99	1	flavonoids; glycoside
(1Ar,7aS,10aS,10bS)-1a,5-dimethyl-8-methylidene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[9,10]cyclodeca[1,2-b]furan-9(1aH)-one [no description available]	2.17	1	germacranolide
panduratin a panduratin A: isolated from Kaempferia pandurata; structure in first source	2.17	1	diarylheptanoid	metabolite
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetrone [no description available]	2.17	1	oligopeptide
13-epi-sclareol 13-epi-sclareol: an unusual labdane diterpene from the roots of Coleus forskohlii with cell growth inhibitory action in breast and uterine cancers in vitro; structure in first source	2.17	1
glutinol glutinol: from a medicinal lichen, Usnea longissima; structure in first source. glutinol : A pentacyclic triterpenoid that is picene which has been fully hydrogenated except for a double bond between the 4a and 5 positions and is substituted by methyl groups at the 4, 4, 6bbeta, 8abeta, 11, 11, 12balpha and 14bbeta positions, and by a hydroxy group at the 3beta position.	2.04	1	pentacyclic triterpenoid; secondary alcohol
kaempferol 7-o-glucoside kaempferol 7-O-glucoside: structure in first source. kaempferol 7-O-beta-D-glucopyranoside : A kaempferol O-glucoside that is kaempferol attached to a beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage.	2.17	1	beta-D-glucoside; flavonols; kaempferol O-glucoside; monosaccharide derivative; trihydroxyflavone	metabolite; plant metabolite; radical scavenger
akuammicine akuammicine: from Strychnos sp;; structure in first source. akuammicine : A monoterpenoid indole alkaloid with formula C20H22N2O2, isolated from several plant species including Alstonia spatulata, Catharanthus roseus and Vinca major.	2.17	1	methyl ester; monoterpenoid indole alkaloid; organic heteropentacyclic compound; tertiary amino compound	plant metabolite
corchoionoside c corchoionoside C: structure given in first source; from leaves of Corchorus olitorius	2.11	1
hermitamide b hermitamide B: isolated from Lyngbya majuscula; structure in first source	2.17	1
trans-delta-tocotrienoloic acid tocotrienoloic acid: from leaves of Tovomitopsis psychotriifolia; structure given in first source	2.17	1	tocotrienol
sl0101 SL0101: p90 Ribosomal S6 Kinase; structure in first source	2.73	3
nodulisporic acid a nodulisporic acid A: a novel indole diterpene insecticide; structure in first source	2.17	1
scopadulcic acid b scopadulcic acid B: isolated from Scorparia dulcis	2.17	1
gliocladin c gliocladin C: structure in first source	2.17	1
zincophorin zincophorin: 25 carbon polypropionate from Streptomyces griseus; griseochelin and M 144255 are the same monocarboxylic acid ionophore	2.17	1	pyrans	bacterial metabolite; ionophore
streptazolin streptazolin: from culture of Streptomyces sp.; structure in first source	2.17	1
chatancin chatancin: structure in first source	2.17	1
scopolamine hydrobromide [no description available]	2.31	1
morelloflavone morelloflavone: also inhibits cruzain; RN given for (2S-trans)-isomer; structure in first source. (+)-morelloflavone : A biflavonoid found in Rheedia edulis and Garcinia livingstonei.	2.17	1	biflavonoid; hydroxyflavanone; hydroxyflavone	plant metabolite
cinnamosmolide cinnamosmolide: isolated from several species of Canellaceae family; structure in first source	2.17	1
15-deoxygoyazensolide 15-deoxygoyazensolide: an NSAID with schistossomicidal and trypanosomicidal activities; structure in first source	2.17	1
mitragynine speciogynine: structure in first source	2.17	1
cytochrome c-t Cytochromes c: Cytochromes of the c type that are found in eukaryotic MITOCHONDRIA. They serve as redox intermediates that accept electrons from MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX III and transfer them to MITOCHONDRIAL ELECTRON TRANSPORT COMPLEX IV.	2.31	1
oenothein a oenothein A: from leaves of Oenothera biennis; structure given in first source	2.15	1
oenothein b oenothein B: from Oenothera erythrosepala Bordas; exhibits strong antitumor activity against MM2 ascites tumors & inhibits the growth of Meth-A solid-type tumors in mice; 5 alpha reductase testosterone inhibitor	2.15	1
spongia-13(16),14-dien-19-oic acid spongia-13(16),14-dien-19-oic acid : A tetracyclic diterpenoid that is 3b,4,5,5a,6,7,8,9,9a,9b,10,11-dodecahydrophenanthro[1,2-c]furan substituted by methyl groups at positions 3b, 6 and 9 and a carboxy group at position 6. Isolated from Spongia, it exhibits inhibitory activity against androgen receptor.	2.17	1	cyclic ether; monocarboxylic acid; tetracyclic diterpenoid	androgen antagonist; metabolite
roquefortine [no description available]	2.17	1	pyrroloindole
3-(3,4-dihydroxyphenyl)lactate 3-(3,4-dihydroxyphenyl)lactate : A hydroxy monocarboxylic acid anion that is the conjugate base of 3-(3,4-dihydroxyphenyl)lactic acid; major species at pH 7.3.	2.17	1	hydroxy monocarboxylic acid anion
marinopyrrole a marinopyrrole A: antibiotic from a marine Streptomyces sp.; structure in first source. (-)-marinopyrrole A : A member of the class of pyrroles that is 1'H-1,3'-bipyrrole substituted by four chloro groups at positions 4, 4', 5 and 5' and two 2-hydroxybenzoyl moieties at positions 2 and 2'. It is isolated from Streptomyces sp.CNQ-418 and exhibits cytotoxic and antibacterial activities.	2.17	1	aromatic ketone; organochlorine compound; phenols; pyrroles	antibacterial agent; antimicrobial agent; antineoplastic agent; bacterial metabolite; marine metabolite
colletoic acid colletoic acid: an 11beta-hydroxysteroid dehydrogenase type 1 inhibitor from Colletotrichum gloeosporioides; structure in first source	2.17	1
ipomoeassin f ipomoeassin F: a cytotoxic macrocyclic glycoresin from the leaves of Ipomoea squamosa from the Suriname rainforest	2.17	1
6,8-dihydroxy-2,2,4,4-tetramethyl-7-(3-methylbutanoyl)-9-(2-methylpropyl)-9h-xanthene-1,3-dione [no description available]	2.17	1	xanthenes
multiflorin a multiflorin A: isolated from Arthromeris mairei	2.04	1	flavonoids; glycoside
7-hydroxymitragynine 7-hydroxymitragynine: an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa; structure in first source	2.17	1	alkaloid
dorrigocin b dorrigocin B: isolated from the fermentation broth & mycelium of Streptomyces platensis; structure given in first source	2.17	1
dorrigocin a dorrigocin A: isolated from the fermentation broth & mycelium of Streptomyces platensis; structure given in first source	2.17	1
isoquercitrin [no description available]	2.54	2
tatanan a tatanan A: from the rhizomes of Acorus tatarinowii Schott; structure in first source	2.17	1
ilicicolin h ilicicolin H: structure in first source. ilicicolin H : An aromatic ketone in which the ketone carbonyl group is attached to a (1R,2R,4aS,7S,8aR)-4,7-dimethyl-1-[(1E)-prop-1-en-1-yl]-1,2,4a,5,6,7,8,8a-octahydronaphthalen-2-yl group and a 4-hydroxy-5-(4-hydroxyphenyl)-2-oxo-1,2-dihydropyridin-3-yl group. Isolated from the from the "imperfect" fungus Cylindrocladium iliciola strain MFC-870.	2.17	1	aromatic ketone; carbobicyclic compound; ilicicolin; monohydroxypyridine; octahydronaphthalenes; phenols; pyridone	antimicrobial agent; mitochondrial respiratory-chain inhibitor
myricetin-3-o-rhamnoside myricetin-3-O-rhamnoside: antioxidant and antigenotoxic from Myrtus communis; structure in first source	2.15	1
tatanan b tatanan B: from the rhizomes of Acorus tatarinowii Schott; structure in first source	2.17	1
gracilioether f gracilioether F: structure in first source	2.17	1
cryptocaryol a cryptocaryol A: from Cryptocarya spp.; structure in first source. cryptocaryol A : A member of the class of 2-pyranones that is 5,6-dihydro-2H-pyran-2-one substituted by a 2,4,6,8,10-pentahydroxypentacosyl group at position 6. It has been isolated from Cryptocarya species.	2.17	1	2-pyranones; pentol	plant metabolite
tetrahydroamentoflavone tetrahydroamentoflavone: isolated from Semecarpus anacardium; structure in first source	2.17	1
nataxazole nataxazole: has antineoplastic activity; isolated from Streptomyces; structure in first source	2.17	1

Condition	Relationship Strength	Studies
Extravascular Hemolysis [description not available]	2.43	2
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	2.43	2
Benign Neoplasms [description not available]	2.06	1
Cancer of Pancreas [description not available]	2.06	1
Cancer of Prostate [description not available]	2.06	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.06	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	2.06	1
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.06	1
Leucocythaemia [description not available]	2.54	2
Leukemia A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)	2.54	2
Blood Pressure, High [description not available]	2.25	1
Hypertension Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.	2.25	1
Kidney Diseases Pathological processes of the KIDNEY or its component tissues.	2.25	1
Congenital Zika Syndrome [description not available]	2.25	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	3.68	8
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.25	1
Carcinoma, Non-Small Cell Lung [description not available]	2.6	1
Cancer of Lung [description not available]	2.6	1
Carcinoma, Non-Small-Cell Lung A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.	2.6	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.6	1
Amentia [description not available]	2.31	1
Dementia An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.	2.31	1
Food Poisoning [description not available]	2.17	1
Diabetes Mellitus A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.	2.17	1
Poisoning, Lead [description not available]	2.25	1
Poisoning, Mercury [description not available]	2.25	1
Heavy Metal Poisoning Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of HEAVY METALS. Acute and chronic exposures can cause ANEMIA; KIDNEY and LIVER damage; PULMONARY EDEMA; MEMORY LOSS and behavioral changes; bone deformities in children; and MISCARRIAGE or PREMATURE LABOR in pregnant women.	2.25	1
Lead Poisoning Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of LEAD or lead compounds.	2.25	1
Mercury Poisoning Poisoning that results from chronic or acute ingestion, injection, inhalation, or skin absorption of MERCURY or MERCURY COMPOUNDS.	2.25	1
Innate Inflammatory Response [description not available]	2.21	1
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.21	1
Infections, Pseudomonas [description not available]	2.1	1
Pseudomonas Infections Infections with bacteria of the genus PSEUDOMONAS.	2.1	1
Asthma, Bronchial [description not available]	2.52	2
Asthma A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).	2.52	2
Bronchial Hyperreactivity Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.	2.11	1
Experimental Lung Inflammation Inflammation of any part, segment or lobe, of the lung parenchyma.	2.11	1
Pneumonia Infection of the lung often accompanied by inflammation.	2.11	1
Anasarca [description not available]	2.11	1
Ache [description not available]	2.11	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.11	1
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	2.11	1
Gastric Ulcer [description not available]	2.13	1
Stomach Ulcer Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	2.13	1
Vitiligo A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.	2.15	1
B16 Melanoma [description not available]	2.08	1
Carcinogenesis The origin, production or development of cancer through genotypic and phenotypic changes which upset the normal balance between cell proliferation and cell death. Carcinogenesis generally requires a constellation of steps, which may occur quickly or over a period of many years.	2.21	1
Acute Necrotizing Encephalitis, Herpetic [description not available]	2.31	1
Encephalitis, Herpes Simplex An acute (or rarely chronic) inflammatory process of the brain caused by SIMPLEXVIRUS infections which may be fatal. The majority of infections are caused by human herpesvirus 1 (HERPESVIRUS 1, HUMAN) and less often by human herpesvirus 2 (HERPESVIRUS 2, HUMAN). Clinical manifestations include FEVER; HEADACHE; SEIZURES; HALLUCINATIONS; behavioral alterations; APHASIA; hemiparesis; and COMA. Pathologically, the condition is marked by a hemorrhagic necrosis involving the medial and inferior TEMPORAL LOBE and orbital regions of the FRONTAL LOBE. (From Adams et al., Principles of Neurology, 6th ed, pp751-4)	2.31	1
Acute Confusional Senile Dementia [description not available]	2.07	1
Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)	2.07	1

kaempferol 3-o-rhamnoside

Description

Cross-References

Synonyms (57)

Research Excerpts

Toxicity

Roles (3)

Drug Classes (3)

Pathways (1)

Protein Targets (5)

Inhibition Measurements

Biological Processes (51)

Molecular Functions (32)

Ceullar Components (8)

Bioassays (204)

Research

Studies (66)

Market Indicators

Research Demand Index: 26.84

Study Types

kaempferol 3-o-rhamnoside

Description

Cross-References

Synonyms (57)

Research Excerpts

Toxicity

Roles (3)

Drug Classes (3)

Pathways (1)

Protein Targets (5)

Inhibition Measurements

Biological Processes (51)

Molecular Functions (32)

Ceullar Components (8)

Bioassays (204)

Research

Studies (66)

Market Indicators

Research Demand Index: 26.84

Study Types

Related Drugs (201)

Related Conditions (51)