| Assay ID | Title | Year | Journal | Article |
|---|
| AID377279 | Selectivity ratio of Ki for delta opioid receptor to kappa opioid receptor | 2006 | Journal of natural products, Jun, Volume: 69, Issue:6
| Synthesis of salvinorin A analogues as opioid receptor probes. |
| AID238722 | Inhibition of [125I]- IOXY binding to human Opioid receptor kappa1 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. |
| AID377277 | Displacement of [125]OXY from kappa opioid receptor | 2006 | Journal of natural products, Jun, Volume: 69, Issue:6
| Synthesis of salvinorin A analogues as opioid receptor probes. |
| AID329903 | Selectivity for human recombinant kappa opioid receptor over human recombinant delta opioid receptor | 2008 | Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
| Herkinorin analogues with differential beta-arrestin-2 interactions. |
| AID1714474 | Antinociceptive activity in male B6-SJL mouse at 1 to 10 mg/kg, ip measured up to 120 mins by warm water tail-flick assay | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| AID244153 | Relative affinity for human opioid receptor delta1 and kappa1 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. |
| AID377278 | Selectivity ratio of Ki for mu opioid receptor to kappa opioid receptor | 2006 | Journal of natural products, Jun, Volume: 69, Issue:6
| Synthesis of salvinorin A analogues as opioid receptor probes. |
| AID1714483 | Neurotoxicity in B6-SJL mouse assessed as induction of motor coordination by rotarod test | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| AID329909 | Agonist activity at mu opioid receptor expressed in HEK293 cells overexpressing GRK2 assessed as induction of beta-arrestin-2-GFP plasma membrane translocation at 10 uM after 10 mins | 2008 | Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
| Herkinorin analogues with differential beta-arrestin-2 interactions. |
| AID329906 | Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay | 2008 | Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
| Herkinorin analogues with differential beta-arrestin-2 interactions. |
| AID1609949 | Agonist activity at full length kappa opioid receptor (unknown origin) relative to control | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID329904 | Agonist activity at human recombinant mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay | 2008 | Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
| Herkinorin analogues with differential beta-arrestin-2 interactions. |
| AID1714481 | Reward liability in Sprague-Dawley rat assessed as increase in conditioned place preference at 5 mg/kg, ip administered starting from day 2 to 7 for 60 mins measured on day 8 for 15 mins | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| AID329912 | Agonist activity at mu opioid receptor expressed in HEK293 cells overexpressing GRK2 assessed as induction of yellow fluorescent protein internalization at 10 uM after 24 hrs | 2008 | Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
| Herkinorin analogues with differential beta-arrestin-2 interactions. |
| AID1714473 | Agonist activity at human mu opiod receptor expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay relative to DAMGO | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| AID1165896 | Agonist activity at MOR (unknown origin) | 2014 | Bioorganic & medicinal chemistry letters, Oct-15, Volume: 24, Issue:20
| Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies. |
| AID238663 | Inhibition of [125I]- IOXY binding to human Opioid receptor mu1 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. |
| AID1714486 | Agonist activity at human kappa opiod receptor expressed in CHO-K1 cells assessed as increase in forskolin induced cAMP production measured after 30 mins by HitHunter luminescence based assay relative to control | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| AID329900 | Displacement of [125I]IOXY from human recombinant delta opioid receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
| Herkinorin analogues with differential beta-arrestin-2 interactions. |
| AID244145 | Relative affinity for human opioid receptor mu1 and kappa1 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. |
| AID329905 | Agonist activity at human recombinant mu opioid receptor expressed in CHO cells by [35S]GTP-gamma-S binding assay relative to DAMGO | 2008 | Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
| Herkinorin analogues with differential beta-arrestin-2 interactions. |
| AID1714470 | Agonist activity at human mu opiod receptor expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| AID1714469 | Agonist activity at human delta opiod receptor expressed in CHO-K1 cells assessed as increase in forskolin induced cAMP production measured after 30 mins by HitHunter luminescence based assay | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| AID329901 | Displacement of [125I]IOXY from human recombinant kappa opioid receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
| Herkinorin analogues with differential beta-arrestin-2 interactions. |
| AID1714491 | Agonist activity at human delta opiod receptor expressed in CHO-K1 cells assessed as increase in forskolin induced cAMP production up to 10 uM measured after 30 mins by HitHunter luminescence based assay relative to control | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| AID240131 | Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor mu1 expressed in CHO cells | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. |
| AID238721 | Inhibition of [125I]- IOXY binding to human Opioid receptor delta1 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. |
| AID1714467 | Agonist activity at human mu opiod receptor expressed in CHO-K1 cells assessed as increase in forskolin induced cAMP production measured after 30 mins by HitHunter luminescence based assay | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| AID240231 | Stimulation of [35S]-GTP gammaS binding to Opioid receptor delta 1 expressed in CHO cells; ND = Not determined | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. |
| AID377275 | Displacement of [125]OXY from mu opioid receptor | 2006 | Journal of natural products, Jun, Volume: 69, Issue:6
| Synthesis of salvinorin A analogues as opioid receptor probes. |
| AID1714472 | Selectivity ratio of EC50 for agonist activity at human kappa opiod receptor expressed in CHO-K1 cells to EC50 for agonist activity at human mu opiod receptor expressed in CHO-K1 cells | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| AID329899 | Displacement of [125I]IOXY from human recombinant mu opioid receptor expressed in CHO cells | 2008 | Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
| Herkinorin analogues with differential beta-arrestin-2 interactions. |
| AID377276 | Displacement of [125]OXY from delta opioid receptor | 2006 | Journal of natural products, Jun, Volume: 69, Issue:6
| Synthesis of salvinorin A analogues as opioid receptor probes. |
| AID240459 | Stimulatory effect on [35S]-GTP gammaS binding to Opioid receptor mu1 expressed in CHO cells compared to 10 uM DAMGO | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. |
| AID1714485 | Agonist activity at human mu opiod receptor expressed in CHO-K1 cells assessed as increase in forskolin induced cAMP production measured after 30 mins by HitHunter luminescence based assay relative to control | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| AID1714488 | Bias factor, ratio of biased agonist activity at human mu opiod receptor expressed in CHO-K1 cells assessed as stimulation of beta-arrestin recruitment to biased agonist activity at human mu opiod receptor expressed in CHO-K1 cells assessed as increase in | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| AID329907 | Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assay relative to (-)-U50,488 | 2008 | Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
| Herkinorin analogues with differential beta-arrestin-2 interactions. |
| AID240142 | Stimulation of [35S]GTP-gamma-S, binding to Opioid receptor kappa1 expressed in CHO cells | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. |
| AID1714471 | Selectivity ratio of EC50 for agonist activity at human delta opiod receptor expressed in CHO-K1 cells to EC50 for agonist activity at human mu opiod receptor expressed in CHO-K1 cells | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| AID1609948 | Agonist activity at full length HA-tagged mu opioid receptor (unknown origin) expressed in HEK293 cells after 1 hr relative too control | 2019 | European journal of medicinal chemistry, Dec-01, Volume: 183 | Progress in the development of more effective and safer analgesics for pain management. |
| AID329902 | Selectivity for human recombinant kappa opioid receptor over human recombinant mu opioid receptor | 2008 | Journal of medicinal chemistry, Apr-24, Volume: 51, Issue:8
| Herkinorin analogues with differential beta-arrestin-2 interactions. |
| AID240464 | Stimulatory effect on [35S]GTP gammaS binding to Opioid receptor kappa1 expressed in CHO cells compared to 500 nM U50,488 | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. |
| AID240469 | Stimulatory effect on [35S]GTP gammaS binding to Opioid receptor delta 1 expressed in CHO cells compared to 500 nM SNC80; ND = Not determined | 2005 | Journal of medicinal chemistry, Jul-28, Volume: 48, Issue:15
| Neoclerodane diterpenes as a novel scaffold for mu opioid receptor ligands. |
| AID1714468 | Agonist activity at human kappa opiod receptor expressed in CHO-K1 cells assessed as increase in forskolin induced cAMP production measured after 30 mins by HitHunter luminescence based assay | 2016 | Journal of medicinal chemistry, 12-22, Volume: 59, Issue:24
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |