| Assay ID | Title | Year | Journal | Article |
|---|
| AID1169080 | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg measured during 1 to 24 hrs by LC-MS method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
| Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties. |
| AID1169117 | Half life in Sprague-Dawley rat at 5 mg/kg, iv measured during 1 to 24 hrs by LC-MS method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
| Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties. |
| AID1169086 | Apparent oral clearance in Sprague-Dawley rat at 10 mg/kg, po measured during 1 to 24 hrs by LC-MS method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
| Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties. |
| AID547810 | Antiarthritic activity in rat assessed as inhibition of adjuent-induced arthritic pain | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23
| The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life. |
| AID547812 | Antiinflammatory activity in rat air pouch model assessed as inhibition of carrageenan-induced PGE2 production | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23
| The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life. |
| AID547816 | Half life in human | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23
| The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life. |
| AID547808 | Antiinflammatory activity in rat air pouch model assessed as inhibition of carrageenan-induced paw edema | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23
| The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life. |
| AID1169119 | Apparent oral clearance in Sprague-Dawley rat at 5 mg/kg, iv measured during 1 to 24 hrs by LC-MS method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
| Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties. |
| AID547811 | Antiinflammatory activity in rat air pouch model assessed as inhibition of carrageenan-induced PGE2 production at 2 mg/kg | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23
| The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life. |
| AID1169118 | AUC (0 to infinity) in Sprague-Dawley rat at 5 mg/kg, iv measured during 1 to 24 hrs by LC-MS method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
| Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties. |
| AID547813 | Half life in rat | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23
| The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life. |
| AID1169082 | Cmax in Sprague-Dawley rat at 10 mg/kg, po measured during 1 to 24 hrs by LC-MS method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
| Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties. |
| AID547805 | Inhibition of human COX1 | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23
| The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life. |
| AID547814 | Half life in dog | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23
| The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life. |
| AID1169115 | Cmax in Sprague-Dawley rat at 5 mg/kg, iv measured during 1 to 24 hrs by LC-MS method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
| Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties. |
| AID1169116 | Volume of distribution in Sprague-Dawley rat at 5 mg/kg, iv measured during 1 to 24 hrs by LC-MS method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
| Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties. |
| AID547809 | Antiinflammatory activity in rat air pouch model assessed as inhibition of carrageenan-induced inflammatory hyperalgesia | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23
| The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life. |
| AID1169083 | Volume of distribution in Sprague-Dawley rat at 10 mg/kg, po measured during 1 to 24 hrs by LC-MS method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
| Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties. |
| AID1169081 | Tmax in Sprague-Dawley rat at 10 mg/kg, po measured during 1 to 24 hrs by LC-MS method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
| Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties. |
| AID1169084 | Half life in Sprague-Dawley rat at 10 mg/kg, po measured during 1 to 24 hrs by LC-MS method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
| Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties. |
| AID547806 | Inhibition of human COX2 | 2010 | Bioorganic & medicinal chemistry letters, Dec-01, Volume: 20, Issue:23
| The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: the second clinical candidate having a shorter and favorable human half-life. |
| AID1169085 | AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, po measured during 1 to 24 hrs by LC-MS method | 2014 | ACS medicinal chemistry letters, Oct-09, Volume: 5, Issue:10
| Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |