Page last updated: 2024-08-07 18:48:59
Neuropeptide FF receptor 1
A neuropeptide FF receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9GZQ6]
Synonyms
G-protein coupled receptor 147;
RFamide-related peptide receptor OT7T022
Research
Bioassay Publications (8)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 3 (37.50) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
N(ω)-Carbamoylation of the Argininamide Moiety: An Avenue to Insurmountable NPY Y1 Receptor Antagonists and a Radiolabeled Selective High-Affinity Molecular Tool ([(3)H]UR-MK299) with Extended Residence Time.Journal of medicinal chemistry, , Nov-25, Volume: 58, Issue:22, 2015
Selective mode of action of guanidine-containing non-peptides at human NPFF receptors.Journal of medicinal chemistry, , Jul-12, Volume: 55, Issue:13, 2012
Identification of an Journal of medicinal chemistry, , 06-10, Volume: 64, Issue:11, 2021
Development of Multifunctional and Orally Active Cyclic Peptide Agonists of Opioid/Neuropeptide FF Receptors that Produce Potent, Long-Lasting, and Peripherally Restricted Antinociception with Diminished Side Effects.Journal of medicinal chemistry, , 09-23, Volume: 64, Issue:18, 2021
Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development.Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020
[no title available]Bioorganic & medicinal chemistry, , 02-15, Volume: 27, Issue:4, 2019
Identification of an Journal of medicinal chemistry, , 06-10, Volume: 64, Issue:11, 2021
Neuropeptide FF and Its Receptors: Therapeutic Applications and Ligand Development.Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020
[no title available]Bioorganic & medicinal chemistry, , 02-15, Volume: 27, Issue:4, 2019
Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 22, Issue:24, 2012
Selective mode of action of guanidine-containing non-peptides at human NPFF receptors.Journal of medicinal chemistry, , Jul-12, Volume: 55, Issue:13, 2012
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| G protein-coupled receptor activity | molecular function | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| neuropeptide receptor activity | molecular function | Combining with a neuropeptide to initiate a change in cell activity. [GOC:ai] |
| peptide binding | molecular function | Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. [GOC:jl] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cilium | cellular component | A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body. [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|
| neuropeptide signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194] |
| biological_process | biological process | A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. [GOC:pdt] |
| G protein-coupled receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] |
| cellular response to hormone stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:mah] |