Compounds > ly 274614
Page last updated: 2024-09-25

ly 274614

Description

LY 235959: RN refers to (3S-(3alpha,4aalpha,6beta,8aalpha))-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID131938
CHEMBL ID1448057
SCHEMBL ID195083
MeSH IDM0192936

Synonyms (33)

Synonym
ly 235959
ly-235959
decahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic acid
3-isoquinolinecarboxylic acid, decahydro-6-(phosphonomethyl)-, (3s-(3alpha,4aalpha,6beta,8aalpha))-
tocris-1019
NCGC00024942-01
BPBIO1_001216
BIOMOL-NT_000192
NCGC00024942-02
(3s,4ar,6s,8ar)-6-(phosphonomethyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid
ly274614
ly 274614
136109-04-1
3-isoquinolinecarboxylic acid, decahydro-6-(phosphonomethyl)-, (3alpha,4aalpha,6beta,8aalpha)-
3-isoquinolinecarboxylic acid, decahydro-6-(phosphonomethyl)-, (3s,4ar,6s,8ar)-
ly-274614
unii-ar2bhc0c6p
ar2bhc0c6p ,
137433-06-8
SCHEMBL195083
CHEMBL1448057
[3s-(3?,4a?,6?,8a?)]-decahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic acid)
AKOS024456335
SR-01000597462-3
sr-01000597462
J-007021
DTXSID20929264
ly-235959;ly235959
Q6460410
(3s,4ar,6s,8ar)-6-(phosphonomethyl)decahydroisoquinoline-3-carboxylic acid
(3s)-(3-alpha-4-alpha,alpha-6-beta-8-alpha,alpha)-decahydro-6-(phosphonomethyl)-3-isoquinolinecarboxylic acid
DTXSID101336227
[3s-(3alpha,4aalpha,6beta,8aalpha)]-decahydro-6-(phosp honomethyl)-3-isoquinolinecarboxylic acid)

Protein Targets (3)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency39.81070.177814.390939.8107AID2147
chromobox protein homolog 1Homo sapiens (human)Potency89.12510.006026.168889.1251AID540317
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency89.12510.050127.073689.1251AID588590
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (95)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's36 (37.89)18.2507
2000's42 (44.21)29.6817
2010's13 (13.68)24.3611
2020's4 (4.21)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (2.08%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other94 (97.92%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
methamphetamine[no description available]medium20amphetamines;
secondary amine		central nervous system stimulant;
environmental contaminant;
neurotoxin;
psychotropic drug;
xenobiotic
bicuculline methiodide[no description available]medium10
bicuculline[no description available]medium20benzylisoquinoline alkaloid;
isoquinoline alkaloid;
isoquinolines		agrochemical;
central nervous system stimulant;
GABA-gated chloride channel antagonist;
GABAA receptor antagonist;
neurotoxin
apomorphine[no description available]medium10aporphine alkaloidalpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug
7-nitroindazole[no description available]medium10
ketamine[no description available]medium20cyclohexanones;
monochlorobenzenes;
secondary amino compound		analgesic;
environmental contaminant;
intravenous anaesthetic;
neurotoxin;
NMDA receptor antagonist;
xenobiotic
sirolimus[no description available]medium10antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
ornithine[no description available]medium10non-proteinogenic L-alpha-amino acid;
ornithine		algal metabolite;
hepatoprotective agent;
mouse metabolite
staurosporine aglycone[no description available]medium10
indazoles[no description available]medium10indazole
cobalt[no description available]medium50cobalt group element atom;
metal allergen		micronutrient
cobaltous chloride[no description available]medium50cobalt salt;
inorganic chloride		allergen;
calcium channel blocker;
sensitiser;
two-colour indicator
homatropine methylbromide[no description available]medium20
nicotine[no description available]medium203-(1-methylpyrrolidin-2-yl)pyridineanxiolytic drug;
biomarker;
immunomodulator;
mitogen;
neurotoxin;
nicotinic acetylcholine receptor agonist;
peripheral nervous system drug;
phytogenic insecticide;
plant metabolite;
psychotropic drug;
teratogenic agent;
xenobiotic
glutamic acid[no description available]medium130glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline[no description available]medium160naphthalenes;
sulfonic acid derivative
quinoxalines[no description available]medium160mancude organic heterobicyclic parent;
naphthyridine;
ortho-fused heteroarene
n-methylaspartate[no description available]medium100amino dicarboxylic acid;
D-alpha-amino acid;
D-aspartic acid derivative;
secondary amino compound		neurotransmitter agent
ng-nitroarginine methyl ester[no description available]medium30alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor
arginine[no description available]medium60arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole[no description available]medium30benzoic acid;
imidazolines;
organic radical		apoptosis inhibitor;
radical scavenger
chlordiazepoxide[no description available]medium20benzodiazepine
propranolol[no description available]medium10naphthalenes;
propanolamine;
secondary amine		anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic
naloxone[no description available]medium40morphinane alkaloid;
organic heteropentacyclic compound;
tertiary alcohol		antidote to opioid poisoning;
central nervous system depressant;
mu-opioid receptor antagonist
morphine[no description available]medium280morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound		anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic
3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol[no description available]medium10alkylbenzene;
ring assembly
cyclohexanol[no description available]medium10cyclohexanols;
secondary alcohol		solvent
corticosterone[no description available]medium1011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
dextromethorphan[no description available]medium706-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthreneantitussive;
environmental contaminant;
neurotoxin;
NMDA receptor antagonist;
oneirogen;
prodrug;
xenobiotic
phencyclidine[no description available]medium20benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
levorphanol[no description available]medium10morphinane alkaloid
substance p[no description available]medium10peptideneurokinin-1 receptor agonist;
neurotransmitter;
vasodilator agent
glycine[no description available]medium30alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
capsaicin[no description available]medium10capsaicinoidnon-narcotic analgesic;
TRPV1 agonist;
voltage-gated sodium channel blocker
alpha-methyl-4-carboxyphenylglycine[no description available]medium10non-proteinogenic alpha-amino acidmetabotropic glutamate receptor antagonist
6-methyl-2-(phenylethynyl)pyridine[no description available]medium10acetylenic compound;
methylpyridines		anxiolytic drug;
metabotropic glutamate receptor antagonist
l 703606[no description available]medium10
quinuclidines[no description available]medium10quinuclidines;
saturated organic heterobicyclic parent
dizocilpine maleate[no description available]medium370maleate salt;
tetracyclic antidepressant		anaesthetic;
anticonvulsant;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist
nimodipine[no description available]medium102-methoxyethyl ester;
C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
isopropyl ester		antihypertensive agent;
calcium channel blocker;
cardiovascular drug;
vasodilator agent
piperidines[no description available]medium30
l 701324[no description available]medium10quinolines
ro 25-6981[no description available]medium10benzenes;
phenols;
piperidines;
secondary alcohol;
tertiary amino compound		anticonvulsant;
antidepressant;
neuroprotective agent;
NMDA receptor antagonist
carbostyril[no description available]medium10monohydroxyquinoline;
quinolone		bacterial xenobiotic metabolite
methadone[no description available]medium20benzenes;
diarylmethane;
ketone;
tertiary amino compound
ifenprodil[no description available]medium10piperidines
1-hydroxy-3-amino-2-pyrrolidone[no description available]medium40
cocaine[no description available]medium30benzoate ester;
methyl ester;
tertiary amino compound;
tropane alkaloid		adrenergic uptake inhibitor;
central nervous system stimulant;
dopamine uptake inhibitor;
environmental contaminant;
local anaesthetic;
mouse metabolite;
plant metabolite;
serotonin uptake inhibitor;
sodium channel blocker;
sympathomimetic agent;
vasoconstrictor agent;
xenobiotic
hydroxyl radical[no description available]medium20oxygen hydride;
oxygen radical;
reactive oxygen species
acetylcysteine[no description available]medium10acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary
2,3-dihydroxybenzoic acid[no description available]medium20dihydroxybenzoic acidhuman xenobiotic metabolite;
plant metabolite
thioctic acid[no description available]medium10dithiolanes;
heterocyclic fatty acid;
thia fatty acid		fundamental metabolite;
geroprotector
butorphanol[no description available]medium10morphinane alkaloidantitussive;
kappa-opioid receptor agonist;
mu-opioid receptor agonist;
opioid analgesic
nalbuphine[no description available]medium10organic heteropentacyclic compoundmu-opioid receptor antagonist;
opioid analgesic
buprenorphine[no description available]medium30morphinane alkaloiddelta-opioid receptor antagonist;
kappa-opioid receptor antagonist;
mu-opioid receptor agonist;
opioid analgesic
arginine vasopressin[no description available]medium10vasopressincardiovascular drug;
hematologic agent;
mitogen
pentolinium tartrate[no description available]medium10tartrate saltantihypertensive agent
pituitrin[no description available]medium10
argipressin,(1-mercaptocyclohexaneacetic acid)(1)-o-ethyl-tyr(2)-[no description available]medium10
dinoprostone[no description available]medium10prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
oxadiazoles[no description available]medium10
1h-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one[no description available]medium10oxadiazoloquinoxalineEC 4.6.1.2 (guanylate cyclase) inhibitor
ag 3-5[no description available]medium10C-nitro compound
pyrimidinones[no description available]medium10
memantine[no description available]medium20adamantanes;
primary aliphatic amine		antidepressant;
antiparkinson drug;
dopaminergic agent;
neuroprotective agent;
NMDA receptor antagonist
pyrroles[no description available]medium10pyrrole;
secondary amine
kynurenic acid[no description available]medium20monohydroxyquinoline;
quinolinemonocarboxylic acid		G-protein-coupled receptor agonist;
human metabolite;
neuroprotective agent;
nicotinic antagonist;
NMDA receptor antagonist;
Saccharomyces cerevisiae metabolite
kt 5720[no description available]medium10carboxylic ester;
gamma-lactam;
hemiaminal;
indolocarbazole;
organic heterooctacyclic compound;
semisynthetic derivative;
tertiary alcohol		EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor
npc 15437[no description available]medium10
dezocine[no description available]medium20phenols;
primary amino compound		opioid analgesic
naltrexone[no description available]medium30cyclopropanes;
morphinane-like compound;
organic heteropentacyclic compound		antidote to opioid poisoning;
central nervous system depressant;
environmental contaminant;
mu-opioid receptor antagonist;
xenobiotic
7-chlorokynurenic acid[no description available]medium10organochlorine compound;
quinolinemonocarboxylic acid		neuroprotective agent;
NMDA receptor antagonist
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine[no description available]medium10methylpyridines;
phenylpyridine;
tetrahydropyridine		neurotoxin
levodopa[no description available]medium10amino acid zwitterion;
dopa;
L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid		allelochemical;
antidyskinesia agent;
antiparkinson drug;
dopaminergic agent;
hapten;
human metabolite;
mouse metabolite;
neurotoxin;
plant growth retardant;
plant metabolite;
prodrug
ly 233053[no description available]medium20
deltorphin ii, ala(2)-[no description available]medium40
enkephalin, leucine[no description available]medium50pentapeptide;
peptide zwitterion		analgesic;
delta-opioid receptor agonist;
human metabolite;
mu-opioid receptor agonist;
neurotransmitter;
rat metabolite
enkephalin, d-penicillamine (2,5)-[no description available]medium30heterodetic cyclic peptidedelta-opioid receptor agonist
u-50488[no description available]medium30dichlorobenzene;
monocarboxylic acid amide;
N-alkylpyrrolidine		analgesic;
antitussive;
calcium channel blocker;
diuretic;
kappa-opioid receptor agonist
fentanyl[no description available]medium10anilide;
monocarboxylic acid amide;
piperidines		adjuvant;
anaesthesia adjuvant;
anaesthetic;
intravenous anaesthetic;
mu-opioid receptor agonist;
opioid analgesic
enkephalin, ala(2)-mephe(4)-gly(5)-[no description available]medium10
gyki 52466[no description available]medium10benzodiazepine
nifedipine[no description available]medium10C-nitro compound;
dihydropyridine;
methyl ester		calcium channel blocker;
human metabolite;
tocolytic agent;
vasodilator agent
nicardipine[no description available]medium10benzenes;
C-nitro compound;
diester;
dihydropyridine;
methyl ester;
tertiary amino compound
flunarizine[no description available]medium10diarylmethane
dynorphins[no description available]medium20
dynorphins[no description available]medium10
etorphine[no description available]medium10
4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-n,n-diethylbenzamide[no description available]medium10diarylmethane
diphenhydramine hydrochloride[no description available]medium10hydrochloride;
organoammonium salt		anti-allergic agent;
antiemetic;
antiparkinson drug;
antipruritic drug;
H1-receptor antagonist;
local anaesthetic;
muscarinic antagonist;
sedative
formaldehyde[no description available]medium10aldehyde;
one-carbon compound		allergen;
carcinogenic agent;
disinfectant;
EC 3.5.1.4 (amidase) inhibitor;
environmental contaminant;
Escherichia coli metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
2-amino-4-oxo-5-chloropentanoate[no description available]medium10
baclofen[no description available]medium10amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid;
monochlorobenzenes;
primary amino compound		central nervous system depressant;
GABA agonist;
muscle relaxant
fluo-3[no description available]medium10xanthene dyefluorochrome
xanthenes[no description available]medium10xanthene
1-aminocyclopropane-1-carboxylic acid[no description available]medium10amino acid zwitterion;
monocarboxylic acid;
non-proteinogenic alpha-amino acid		ethylene releasers;
plant metabolite
nitroarginine[no description available]medium20guanidines;
L-arginine derivative;
N-nitro compound;
non-proteinogenic L-alpha-amino acid
alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid[no description available]medium20non-proteinogenic alpha-amino acid
clonidine[no description available]medium10clonidine;
imidazoline
malonic acid[no description available]medium10alpha,omega-dicarboxylic acidhuman metabolite
2-amino-5-phosphonovalerate[no description available]medium10non-proteinogenic alpha-amino acidNMDA receptor antagonist
cgp 37849[no description available]medium10
selfotel[no description available]medium20non-proteinogenic alpha-amino acid
npc 12626[no description available]medium20
phenyl acetate[no description available]medium10benzenes;
phenyl acetates
urethane[no description available]medium10carbamate esterfungal metabolite;
mutagen
acetic acid[no description available]medium10monocarboxylic acidantimicrobial food preservative;
Daphnia magna metabolite;
food acidity regulator;
protic solvent
midazolam[no description available]medium10imidazobenzodiazepine;
monofluorobenzenes;
organochlorine compound		anticonvulsant;
antineoplastic agent;
anxiolytic drug;
apoptosis inducer;
central nervous system depressant;
GABAA receptor agonist;
general anaesthetic;
muscle relaxant;
sedative
morphine-3-glucuronide[no description available]medium10morphinane alkaloid
pentylenetetrazole[no description available]medium10organic heterobicyclic compound;
organonitrogen heterocyclic compound
trifluoperazine[no description available]medium10N-alkylpiperazine;
N-methylpiperazine;
organofluorine compound;
phenothiazines		antiemetic;
calmodulin antagonist;
dopaminergic antagonist;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor;
phenothiazine antipsychotic drug
clebopride[no description available]medium10piperidines
haloperidol[no description available]medium10aromatic ketone;
hydroxypiperidine;
monochlorobenzenes;
organofluorine compound;
tertiary alcohol		antidyskinesia agent;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic;
serotonergic antagonist
oxybutynin[no description available]medium10acetylenic compound;
carboxylic ester;
racemate;
tertiary alcohol;
tertiary amino compound		antispasmodic drug;
calcium channel blocker;
local anaesthetic;
muscarinic antagonist;
muscle relaxant;
parasympatholytic
2-amino-5-phosphonomethyl(1,1'-biphenyl)-3-propanoic acid[no description available]medium10
cyclic gmp[no description available]medium103',5'-cyclic purine nucleotide;
guanyl ribonucleotide		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
spermine[no description available]medium10polyazaalkane;
tetramine		antioxidant;
fundamental metabolite;
immunosuppressive agent
gamma-aminobutyric acid[no description available]medium10amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
zaprinast[no description available]medium10triazolopyrimidines
1-methyl-3-isobutylxanthine[no description available]medium103-isobutyl-1-methylxanthine
8-bromocyclic gmp[no description available]medium103',5'-cyclic purine nucleotide;
organobromine compound		muscle relaxant;
protein kinase G agonist
iprindole[no description available]medium10indoles
amphetamine[no description available]medium10primary amine
kainic acid[no description available]medium10dicarboxylic acid;
L-proline derivative;
non-proteinogenic L-alpha-amino acid;
pyrrolidinecarboxylic acid		antinematodal drug;
excitatory amino acid agonist
ibotenic acid[no description available]medium10non-proteinogenic alpha-amino acidneurotoxin
quisqualic acid[no description available]medium10non-proteinogenic alpha-amino acid
ConditionIndicatedRelationship StrengthStudiesTrials
Absence Seizure0low20
Absence Seizures0low20
Acathisia, Drug-Induced0low10
Ache0low80
Action Tremor0low10
Acute Confusional Senile Dementia0low10
Addiction, Opioid0low30
Aging0low10
Akathisia, Drug-Induced0low10
Akathisia, Tardive0low10
Alcohol Abuse0low10
Alcohol Abuse, Nervous System0low10
Alcohol Addiction0low10
Alcohol Dependence0low10
Alcohol Drinking0low20
Alcohol Use Disorder0low10
Alcohol-Induced Disorders, Nervous System0low10
Alcoholic Intoxication, Chronic0low10
Alcoholism0low10
Allodynia0low20
Allodynia, Mechanical0low20
Allodynia, Tactile0low20
Allodynia, Thermal0low20
Alzheimer Dementia0low10
Alzheimer Disease0low10
Alzheimer Disease, Early Onset0low10
Alzheimer Disease, Late Onset0low10
Alzheimer Sclerosis0low10
Alzheimer Syndrome0low10
Alzheimer Type Senile Dementia0low10
Alzheimer-Type Dementia (ATD)0low10
Alzheimer's Disease0low10
Alzheimer's Disease, Focal Onset0low10
Alzheimer's Diseases0low10
Anesthesia0low40
Anochlesia0low10
Anxiety0low10
Atherosclerotic Parkinsonism0low10
Atonic Absence Seizure0low20
Atonic Absence Seizures0low20
Atonic Seizure0low20
Atonic Seizures0low20
Aura0low10
Awakening Epilepsy0low10
Bradyarrhythmia0low40
Bradyarrhythmias0low40
Bradycardia0low40
Brain Diseases0low10
Brain Disorders0low10
Cannabis Abuse0low10
Cannabis Dependence0low10
Cannabis-Related Disorder0low10
Catalepsy0low10
Central Nervous System Disorders, Intracranial0low10
Central Nervous System Intracranial Disorders0low10
Cerea Flexibilitas0low10
Chorea0low10
Chorea Disorders0low10
Chorea Syndromes0low10
Chorea, Benign Hereditary0low10
Chorea, Chronic Progressive0low10
Chorea, Rheumatic0low10
Chorea, Senile0low10
Chorea, Sydenham0low10
Choreatic Disorders0low10
Choreatic Syndromes0low10
Choreic Movement0low10
Choreiform Movement0low10
Chronic Pain0low10
Clonic Seizure0low20
Clonic Seizures0low20
CNS Disorders, Intracranial0low10
Coarse Tremor0low10
Cocaine Abuse0low10
Cocaine Addiction0low10
Cocaine Dependence0low10
Cocaine-Related Disorders0low10
Complex Partial Seizure0low20
Complex Partial Seizures0low20
Congenital Zika Syndrome0low10
Congenital Zika Virus Infection0low10
Continuous Tremor0low10
Convulsion0low20
Convulsion, Non-Epileptic0low20
Convulsions0low20
Convulsive Seizure0low20
Convulsive Seizures0low20
Darkness Tremor0low10
Decerebrate Posturing0low10
Decerebrate State0low10
Decorticate Rigidity0low10
Decorticate State0low10
Dementia, Alzheimer Type0low10
Dementia, Presenile0low10
Dementia, Primary Senile Degenerative0low10
Dementia, Senile0low10
Dependence, Opioid0low30
Depression0low20
Disease Models, Animal0low70
Drug Withdrawal Symptoms0low50
Drug-Induced Akathisia0low10
Dyskinesia, Drug-Induced0low10
Dyskinesia, Medication-Induced0low10
Dyskinesias, Paroxysmal0low10
Dystonia0low10
Dystonia, Diurnal0low10
Dystonia, Limb0low10
Dystonia, Paroxysmal0low10
Early Onset Alzheimer Disease0low10
Encephalon Diseases0low10
Encephalopathy0low10
Epilepsy0low10
Epilepsy, Cryptogenic0low10
Epileptic Seizure0low20
Epileptic Seizures0low20
Ethanol Abuse0low10
Ethanol Induced Nervous System Disorders0low10
Ethanol-Induced Disorders, Nervous System0low10
Ethanol-Induced Nervous System Disorders0low10
Ethyl Alcohol Abuse Neurologic Syndromes0low10
Familial Alzheimer Disease (FAD)0low10
Fever0low30
Fever, Zika0low10
Fine Tremor0low10
Flexibility, Waxy0low10
Focal Onset Alzheimer's Disease0low10
Generalized Absence Seizure0low20
Generalized Absence Seizures0low20
Generalized Tonic-Clonic Seizures0low20
Genetic Predisposition0low10
Genetic Predisposition to Disease0low10
Genetic Susceptibility0low10
Hashish Abuse0low10
Hereditary Chorea0low10
Hereditary Progressive Chorea Without Dementia0low10
Hyperalgesia0low20
Hyperalgesia, Mechanical0low20
Hyperalgesia, Primary0low20
Hyperalgesia, Secondary0low20
Hyperalgesia, Tactile0low20
Hyperalgesia, Thermal0low20
Hyperalgesic Sensations0low20
Hyperalgia0low20
Hyperalgia, Mechanical0low20
Hyperalgia, Primary0low20
Hyperalgia, Secondary0low20
Hypothermia0low10
Hypothermia, Accidental0low10
Intention Tremor0low10
Intermittent Tremor0low10
Intracranial Central Nervous System Disorders0low10
Intracranial CNS Disorders0low10
Involuntary Quiver0low10
Jacksonian Seizure0low20
Late Onset Alzheimer Disease0low10
Marihuana Abuse0low10
Marijuana Abuse0low10
Marijuana Dependence0low10
Massive Tremor0low10
Mechanical Allodynia0low20
Mechanical Hyperalgesia0low20
Medication-Induced Dyskinesia0low10
Morphine Abuse0low10
Morphine Addiction0low10
Morphine Dependence0low10
Muscle Contraction0low10
Muscle Dystonia0low10
Myoclonic Seizure0low20
Myoclonic Seizures0low20
Nerve Degeneration0low20
Nerve Pain0low10
Nervous System Diseases0low10
Nervous System Disorders0low10
Nervous System Disorders, Ethanol-Induced0low10
Neuralgia0low10
Neuralgia, Atypical0low10
Neuralgia, Iliohypogastric Nerve0low10
Neuralgia, Ilioinguinal0low10
Neuralgia, Perineal0low10
Neuralgia, Stump0low10
Neuralgia, Supraorbital0low10
Neuralgia, Vidian0low10
Neurodynia0low10
Neurologic Disorders0low10
Neurological Disorders0low10
Neuron Degeneration0low20
Neuropathic Pain0low10
Nociceptive Pain0low10
Non-Epileptic Seizure0low20
Non-Epileptic Seizures0low20
Nonepileptic Seizure0low20
Nonepileptic Seizures0low20
Opiate Abuse0low30
Opiate Addiction0low30
Opiate Dependence0low30
Opioid Abuse0low30
Opioid Addiction0low30
Opioid Dependence0low30
Opioid Misuse0low30
Opioid Use Disorder0low30
Opioid-Related Disorders0low30
Pain0low80
Pain, Burning0low80
Pain, Chronic0low10
Pain, Crushing0low80
Pain, Migratory0low80
Pain, Radiating0low80
Pain, Splitting0low80
Parkinson Disease, Secondary0low10
Parkinson Disease, Secondary Vascular0low10
Parkinson Disease, Symptomatic0low10
Parkinsonism, Secondary0low10
Parkinsonism, Symptomatic0low10
Paroxysmal Dyskinesias0low10
Paroxysmal Nerve Pain0low10
Partial Seizure0low20
Partial Seizures0low20
Passive Tremor0low10
Persistent Tremor0low10
Petit Mal Convulsion0low20
Pill Rolling Tremor0low10
Predisposition, Genetic0low10
Pregnancy0low10
Prescription Opioid Abuse0low30
Prescription Opioid Misuse0low30
Presenile Alzheimer Dementia0low10
Primary Senile Degenerative Dementia0low10
Pseudoakathisia0low10
Pyrexia0low30
Rest Tremor0low10
Resting Tremor0low10
Rheumatic Chorea0low10
Rigidity, Decerebrate0low10
Rigidity, Decorticate0low10
Saturnine Tremor0low10
Secondary Parkinsonism0low10
Secondary Vascular Parkinson Disease0low10
Seizure0low20
Seizure Disorder0low10
Seizures0low20
Seizures, Auditory0low20
Seizures, Clonic0low20
Seizures, Convulsive0low20
Seizures, Epileptic0low20
Seizures, Focal0low20
Seizures, Generalized0low20
Seizures, Gustatory0low20
Seizures, Motor0low20
Seizures, Olfactory0low20
Seizures, Sensory0low20
Seizures, Somatosensory0low20
Seizures, Tonic0low20
Seizures, Tonic-Clonic0low20
Seizures, Vertiginous0low20
Seizures, Vestibular0low20
Seizures, Visual0low20
Senile Chorea0low10
Senile Dementia, Acute Confusional0low10
Senile Dementia, Alzheimer Type0low10
Senile Tremor0low10
Single Seizure0low20
Somatic Pain0low10
St. Vitus's Dance0low10
Static Tremor0low10
Substance Withdrawal Syndrome0low50
Suffering, Physical0low80
Susceptibility, Genetic0low10
Sydenham Chorea0low10
Sydenham's Chorea0low10
Symptomatic Parkinson Disease0low10
Tachyarrhythmia0low10
Tachycardia0low10
Tactile Allodynia0low20
Thermal Allodynia0low20
Tissue Pain0low10
Tonic Clonic Seizure0low20
Tonic Seizure0low20
Tonic Seizures0low20
Tonic-Clonic Seizure0low20
Tonic-Clonic Seizures0low20
Tremor0low10
Tremor, Limb0low10
Tremor, Muscle0low10
Tremor, Neonatal0low10
Tremor, Nerve0low10
Tremor, Perioral0low10
Tremor, Semirhythmic0low10
Widespread Chronic Pain0low10
Withdrawal Symptoms0low50
Zika Fever0low10
Zika Virus Disease0low10
Zika Virus Infection0low10
ZikV Infection0low10

Research Highlights

Safety/Toxicity (2)

ArticleYear
The selective and competitive N-methyl-D-aspartate receptor antagonist, (-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid, prevents synaptic toxicity induced by amyloid-β in mice.
Neuroscience, Sep-29, Volume: 192		2011
Protection against amphetamine-induced neurotoxicity toward striatal dopamine neurons in rodents by LY274614, an excitatory amino acid antagonist.
Neuropharmacology, Volume: 31, Issue: 10		1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Long-term Use (6)

ArticleYear
Opioid antinociception, tolerance and dependence: interactions with the N-methyl-D-aspartate system in mice.
Behavioural pharmacology, Volume: 22, Issue: 5-6		2011
Role of morphine maintenance dose in the development of tolerance and its attenuation by an NMDA receptor antagonist.
Psychopharmacology, Volume: 148, Issue: 1		2000
The competitive NMDA receptor antagonist LY235959 modulates the progression of morphine tolerance in rats.
Psychopharmacology, Volume: 142, Issue: 2		1999
Differential effects of LY235959, a competitive antagonist of the NMDA receptor on kappa-opioid receptor agonist induced responses in mice and rats.
Brain research, Feb-07, Volume: 747, Issue: 2		1997
Effect of antagonism of the NMDA receptor on tolerance to [D-Pen2,D-Pen5]enkephalin, a delta 1-opioid receptor agonist.
Peptides, Volume: 17, Issue: 2		1996
Effects of N-methyl-D-aspartate receptor antagonists on the analgesia and tolerance to D-Ala2, Glu4 deltorphin II, a delta 2-opioid receptor agonist in mice.
Brain research, May-06, Volume: 719, Issue: 1-2		1996
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (3)

ArticleYear
Competitive and non-competitive NMDA antagonists block the development of antinociceptive tolerance to morphine, but not to selective mu or delta opioid agonists in mice.
Pain, Volume: 68, Issue: 2-3		1996
Modulation of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist LY274614: assessment of opioid receptor changes.
The Journal of pharmacology and experimental therapeutics, Volume: 268, Issue: 1		1994
The NMDA receptor antagonists, LY274614 and MK-801, and the nitric oxide synthase inhibitor, NG-nitro-L-arginine, attenuate analgesic tolerance to the mu-opioid morphine but not to kappa opioids.
Pain, Volume: 56, Issue: 1		1994
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]