Page last updated: 2024-12-10

kaempferol-3-o-galactoside

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

kaempferol-3-O-galactoside: isolated from Ardisia pusilla; RN given refers to (3-(beta-D-galactopyranosyloxy))-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

kaempferol 3-O-beta-D-galactoside : A beta-D-galactoside compound with a 4',5,7-trihydroxychromen-3-yl group at the anomeric position. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID5282149
CHEMBL ID453290
CHEBI ID31742
SCHEMBL ID572365
MeSH IDM0182245

Synonyms (42)

Synonym
trifoliin
kaempferol 3-o-beta-d-galactoside
23627-87-4
kaempferol-3-o-galactoside
trifolin
MEGXP0_000499
ACON1_000322
trifolioside
5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4h-chromen-3-yl beta-d-galactopyranoside
CHEBI:31742 ,
BRD-K09085848-001-01-1
CHEMBL453290 ,
bdbm50313764
kaempferol-3-o-beta-galactopyranoside
5,7-dihydroxy-2-(4-hydroxyphenyl)-3-((2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yloxy)-4h-chromen-4-one
kaempferol-3-o-beta-d-galactoside
7ckd5et5sp ,
4h-1-benzopyran-4-one, 3-(beta-d-galactopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-4-one
SCHEMBL572365
kaempferol 3-o-d-galactoside
kaempferol 3-galactoside
kaempferol 3-o-galactoside
3-o-b-d-galactopyranosyloxy-4',5,7-trihydroxyflavone
AKOS032962714
Q7841515
MS-28113
kaempferol 3-o-beta-d-galactopyranoside
DTXSID30946447
CS-0034340
kaempferol 3-o-|a-d-galactopyranoside
HY-N6605
3-(.beta.-d-galactopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-one
kaempferol 3-o-galactopyranoside
4h-1-benzopyran-4-one, 3-(.beta.-d-galactopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-
kaempferol 3-.beta.-d-galactoside
kaempferol 3-o-.beta.-d-galactopyranoside
kaempferol-3-o-d-galactopyranoside
kaempferol 3-.beta.-d-galactopyranoside
kaempferol 3-o-.beta.-galactoside
5,7-dihydroxy-2-(4-hydroxyphenyl)-3-((2s,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxychromen-4-one
GLXC-14095
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
plant metaboliteAny eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
antifungal agentAn antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
beta-D-galactosideAny D-galactoside having beta-configuration at its anomeric centre.
monosaccharide derivativeA carbohydrate derivative that is formally obtained from a monosaccharide.
glycosyloxyflavoneA member of the class of flavones having one or more glycosyl residues attached at unspecified positions.
trihydroxyflavoneAny hydroxyflavone carrying three hydroxy groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Angiotensin-converting enzymeOryctolagus cuniculus (rabbit)IC50 (µMol)260.00000.00001.612910.0000AID464081; AID612411
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (20)

Assay IDTitleYearJournalArticle
AID1266873Antioxidant activity assessed as reactive oxygen species scavenging activity2015Journal of natural products, Nov-25, Volume: 78, Issue:11
Flavoalkaloids and Flavonoids from Astragalus monspessulanus.
AID430311Cytotoxicity against BALB/c mouse J774.2 cells after 72 hrs by trypan blue assay2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID401230Selectivity index, ratio of CC50 for MDCK cells to IC50 for influenza virus type A H1N12004Journal of natural products, Apr, Volume: 67, Issue:4
Antiviral flavonoids from the seeds of Aesculus chinensis.
AID401228Selectivity index, ratio of CC50 for MDCK cells to IC50 for PIV32004Journal of natural products, Apr, Volume: 67, Issue:4
Antiviral flavonoids from the seeds of Aesculus chinensis.
AID338974Inhibition of cow milk xanthine oxidase at 50 ug/mL
AID430217Antileishmanial activity against extracellular Leishmania peruviana promastigotes after 72 hrs2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID464081Inhibition of ACE in rabbit lung assessed as decrease in dansylglycine concentration after 5 mins by HPLC analysis2010Bioorganic & medicinal chemistry letters, Mar-15, Volume: 20, Issue:6
The synthesis and angiotensin converting enzyme (ACE) inhibitory activity of chalcones and their pyrazole derivatives.
AID430218Antileishmanial activity against extracellular Leishmania braziliensis promastigotes after 72 hrs2009Journal of natural products, Jun, Volume: 72, Issue:6
Antileishmaniasis activity of flavonoids from Consolida oliveriana.
AID650646Inhibition of aldehyde dehydrogenase2012Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
Tea catechins and flavonoids from the leaves of Camellia sinensis inhibit yeast alcohol dehydrogenase.
AID401225Cytotoxicity against MDCK cells2004Journal of natural products, Apr, Volume: 67, Issue:4
Antiviral flavonoids from the seeds of Aesculus chinensis.
AID401227Antiviral activity against PIV3 in MDCK cells assessed as inhibition of virus-induced cytopathic effect2004Journal of natural products, Apr, Volume: 67, Issue:4
Antiviral flavonoids from the seeds of Aesculus chinensis.
AID650647Activation of aldehyde dehydrogenase2012Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
Tea catechins and flavonoids from the leaves of Camellia sinensis inhibit yeast alcohol dehydrogenase.
AID612411Inhibition of rabbit lung ACE assessed as reduction in hippuryl-histidyl-leucine substrate by colorimetric assay2011Bioorganic & medicinal chemistry, Aug-15, Volume: 19, Issue:16
Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors.
AID401229Antiviral activity against influenza virus type A H1N1 in MDCK cells assessed as inhibition of virus-induced cytopathic effect2004Journal of natural products, Apr, Volume: 67, Issue:4
Antiviral flavonoids from the seeds of Aesculus chinensis.
AID401226Selectivity index, ratio of CC50 for MDCK cells to IC50 for RSV Long2004Journal of natural products, Apr, Volume: 67, Issue:4
Antiviral flavonoids from the seeds of Aesculus chinensis.
AID650644Inhibition of Saccharomyces cerevisiae alcohol dehydrogenase measured every 5 mins for 2 hrs by spectrophotometry2012Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
Tea catechins and flavonoids from the leaves of Camellia sinensis inhibit yeast alcohol dehydrogenase.
AID356426Antioxidant activity assessed as DPPH free radical scavenging activity at 250 uM2003Journal of natural products, Sep, Volume: 66, Issue:9
Constituents from the leaves of Phellodendron amurense var. wilsonii and their bioactivity.
AID650645Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometry2012Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7
Tea catechins and flavonoids from the leaves of Camellia sinensis inhibit yeast alcohol dehydrogenase.
AID401224Antiviral activity against RSV Long in MDCK cells assessed as inhibition of virus-induced cytopathic effect2004Journal of natural products, Apr, Volume: 67, Issue:4
Antiviral flavonoids from the seeds of Aesculus chinensis.
AID1266872Hepatoprotective activity against tert-butyl hydroperoxide-induced oxidative stress in Wistar rat hepatocytes assessed as cell viability at 60 ug/ml by tryphan blue exclusion method (Rvb = 74%)2015Journal of natural products, Nov-25, Volume: 78, Issue:11
Flavoalkaloids and Flavonoids from Astragalus monspessulanus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (23)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (4.35)18.7374
1990's2 (8.70)18.2507
2000's6 (26.09)29.6817
2010's11 (47.83)24.3611
2020's3 (13.04)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.51

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.51 (24.57)
Research Supply Index3.22 (2.92)
Research Growth Index5.10 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.51)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other24 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]