ketoconazole has been researched along with Pain in 6 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Endogenous TRPV1 agonists such as oxidized linoleic acid metabolites (OLAMs) and the enzymes releasing them [eg, cytochrome P450 (CYP)] are up-regulated after inflammation in the rat." | 7.79 | Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain. ( de Almeida, JFA; Eskander, M; Hargreaves, KM; Henry, MA; Roman, L; Rowan, S; Ruparel, S, 2013) |
| "We investigated the role and mechanism of action of dehydroepiandrosterone (DHEA) produced by the spinal cord (SC) in pain modulation in sciatic-neuropathic and control rats." | 7.74 | Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord. ( Kibaly, C; Mensah-Nyagan, AG; Meyer, L; Patte-Mensah, C, 2008) |
| "Pretreatment with ketoconazole inhibited the release of TRPV1 agonists in lipid extracts from inflamed skin and significantly reversed CFA-induced heat hyperalgesia by a peripheral mechanism of action." | 5.38 | The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. ( Chen, P; Green, D; Hargreaves, KM; Ruparel, S, 2012) |
| "Endogenous TRPV1 agonists such as oxidized linoleic acid metabolites (OLAMs) and the enzymes releasing them [eg, cytochrome P450 (CYP)] are up-regulated after inflammation in the rat." | 3.79 | Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain. ( de Almeida, JFA; Eskander, M; Hargreaves, KM; Henry, MA; Roman, L; Rowan, S; Ruparel, S, 2013) |
| "We investigated the role and mechanism of action of dehydroepiandrosterone (DHEA) produced by the spinal cord (SC) in pain modulation in sciatic-neuropathic and control rats." | 3.74 | Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord. ( Kibaly, C; Mensah-Nyagan, AG; Meyer, L; Patte-Mensah, C, 2008) |
| "Pretreatment with ketoconazole inhibited the release of TRPV1 agonists in lipid extracts from inflamed skin and significantly reversed CFA-induced heat hyperalgesia by a peripheral mechanism of action." | 1.38 | The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. ( Chen, P; Green, D; Hargreaves, KM; Ruparel, S, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruparel, S | 3 |
| Hargreaves, KM | 3 |
| Eskander, M | 1 |
| Rowan, S | 1 |
| de Almeida, JFA | 1 |
| Roman, L | 2 |
| Henry, MA | 2 |
| Green, DP | 1 |
| Green, D | 1 |
| Chen, P | 1 |
| Pagano, R | 1 |
| Kibaly, C | 1 |
| Meyer, L | 1 |
| Patte-Mensah, C | 1 |
| Mensah-Nyagan, AG | 1 |
| Eichenberger, T | 1 |
| Trachtenberg, J | 1 |
1 trial available for ketoconazole and Pain
| Article | Year |
|---|---|
Value of colposcopy in the diagnosis of candidiasis in patients with vulvodynia.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Candidiasis; Colposcopy; Female; Fluconazole; Humans; Ke | 2007 |
5 other studies available for ketoconazole and Pain
| Article | Year |
|---|---|
Oxidized linoleic acid metabolite-cytochrome P450 system (OLAM-CYP) is active in biopsy samples from patients with inflammatory dental pain.
Topics: Animals; Biopsy; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrom | 2013 |
Role of endogenous TRPV1 agonists in a postburn pain model of partial-thickness injury.
Topics: Animals; Behavior, Animal; Benzothiazoles; Burns; Chromatography, High Pressure Liquid; Hot Temperat | 2013 |
The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain.
Topics: Animals; Antibodies; Behavior, Animal; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme S | 2012 |
Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord.
Topics: Animals; Base Sequence; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cy | 2008 |
Effects of high-dose ketoconazole in patients with androgen-independent prostatic cancer.
Topics: Acid Phosphatase; Aged; Aged, 80 and over; Alkaline Phosphatase; Humans; Ketoconazole; Male; Middle | 1988 |