bicuculline and Pain
bicuculline has been researched along with Pain in 101 studies
Research
Studies (101)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (12.87) | 18.7374 |
| 1990's | 25 (24.75) | 18.2507 |
| 2000's | 35 (34.65) | 29.6817 |
| 2010's | 24 (23.76) | 24.3611 |
| 2020's | 4 (3.96) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Gold, MS; Loeza-Alcocer, E | 1 |
| Flores-Murrieta, FJ; Gonzalez-Cortazar, M; Herrera-Ruiz, ML; Juárez-Aragón, MC; Molina-Cabrera, J; Montiel-Ruiz, RM; Vargas-Ruiz, R; Zamilpa, A | 1 |
| Chen, J; Hasanein, P; Komaki, A; Yari, S | 1 |
| Ahmad, S; Ahn, MJ; Ali, A; Faheem, M; Khalil, AAK; Nasir, A; Nazir, N; Nisar, M; Sajjad, W; Shah, SMM; Shah, SWA; Shoaib, M; Subhan, F | 1 |
| Grau, JW; Huang, YJ | 1 |
| Akerman, S; Goadsby, PJ; Holland, PR; Lasalandra, MP | 1 |
| Aissouni, Y; Chalus, M; Courteix, C; Dupuis, A; Eschalier, A; Hernández, A; Marin, P; Pelissier, T; Pichon, X; Privat, AM; Wattiez, AS | 1 |
| Coutinho, MR; Ferreira, MD; Menescal-de-Oliveira, L; Zugaib, J | 1 |
| Bach-Rojecky, L; Drinovac, V; Lacković, Z | 1 |
| Fang, H; Furmanski, O; Huganir, RL; Johns, RA; Li, C; Liu, S; Skinner, J; Tao, F; Xing, Y; Yang, Y; Zhang, Y | 1 |
| Arase, M; Bertolini, JF; Fischer, L; Lima, MMS; Pontarolla, FM; Tobaldini, G; Tomim, DH | 1 |
| Ang, ST; Foo, FC; Khanna, S; Lee, AT; Low, CM; Ng, L | 1 |
| Chen, L; Dong, Z; Han, H; Tan, T; Wang, W | 1 |
| Artola, A; Bourgois, N; Dallel, R; Peirs, C | 1 |
| Bach-Rojecky, L; Drinovac Vlah, V; Lacković, Z | 1 |
| Hasanein, P; Javanmardi, K; Mirazi, N | 1 |
| Li, X; Xu, MY; Xu, Y | 1 |
| Lu, Y; Xiong, L; Yang, J; Zheng, J; Zimmermann, M | 1 |
| Khanna, S; Zheng, F | 1 |
| Condés-Lara, M; López-Hidalgo, M; Martínez-Lorenzana, G; Rodríguez-Jiménez, J; Rojas-Piloni, G | 1 |
| Luo, F; Wang, JY; Wang, N | 1 |
| Abe, T; Kobayashi, M; Satoh, F; Sugiyo, S; Takemura, M; Uehashi, D; Yonehara, N | 1 |
| Coutinho, MR; da Silva, LF; Menescal-de-Oliveira, L | 1 |
| Aicher, SA; Arttamangkul, S; Bobeck, EN; Hegarty, DM; Ingram, SL; Macey, TA; Morgan, MM | 1 |
| Prado, WA; Silva, JR; Silva, ML | 1 |
| Janahmadi, M; Javan, M; Khakpay, R; Semnanian, S | 1 |
| Choi, EJ; Kim, JH; Lee, CJ; Park, C; Shin, HS; Yoon, BE | 1 |
| Lee, IO; Lim, ES | 1 |
| An, YY; Cao, FL; Chen, J; Gao, CY; Gong, KR; He, Y; Li, H; Lin, Q; Wang, DD; Zhang, FK | 1 |
| Humphries, MD | 1 |
| Maione, S; Neugebauer, V; Palazzo, E; Ren, W | 1 |
| Ji, G; Neugebauer, V | 1 |
| Furue, H; Hur, SW; Imoto, K; Kase, D; Kawamata, M; Kim, SJ; Pickering, AE; Sugiyama, D | 1 |
| Malmierca, E; Martin, YB; Nuñez, A | 1 |
| Boccella, S; De Chiaro, M; de Novellis, V; Gatta, L; Giordano, C; Guida, F; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Siniscalco, D; Vita, D | 1 |
| Saab, CY; Willis, WD | 1 |
| Boscan, P; Kasparov, S; Paton, JF | 1 |
| Bartsch, T; Goadsby, PJ; Knight, YE | 2 |
| Degtyarenko, AM; Kaufman, MP | 1 |
| Radhakrishnan, R; Rohlwing, JJ; Skyba, DA; Sluka, KA; Wright, A | 1 |
| Ikeda, H; Kusudo, K; Murase, K; Ryu, PD | 1 |
| Gear, RW; Levine, JD; Quang, P; Tambeli, CH | 1 |
| Fang, L; Lin, Q; Ren, Y; Wang, J; Willis, WD; Zou, X | 1 |
| Drew, GM; Duggan, AW; Siddall, PJ | 1 |
| Bae, YC; Cho, JH; Choi, BJ; Choi, IS; Jung, SC; Kim, JH; Lee, MG; Shin, HC | 1 |
| Fink, DJ; Glorioso, JC; Hao, S; Huang, S; Liu, J; Mata, M; Wolfe, D | 1 |
| Cao, JL; Dai, TJ; Wang, QY; Zeng, YM | 1 |
| Ojewole, JA | 1 |
| Borszcz, GS | 1 |
| Cervero, F; Garcia-Nicas, E; Laird, JM | 1 |
| Calvo, F; Coimbra, NC | 1 |
| Hossein-Abad, AA; Sahebgharani, M; Zarrindast, MR | 1 |
| Chalus, M; Lopez-Avila, A; Molat, JL; Monconduit, L; Villanueva, L | 1 |
| Cao, DQ; Chang, YT; Chen, YP; Tan, CH; Xu, JM | 1 |
| Fuchs, PN; LaGraize, SC | 1 |
| Castro, M; Duarte, I; Francischi, J; Pacheco, D; Perez, A; Reis, G | 1 |
| Chen, Q; Dong, L; Fu, CY; Ni, JM; Wang, R; Zhao, YL | 1 |
| Sawynok, J | 1 |
| Ignatov, IuD; Petrova, IuV; Poshivalov, VP | 1 |
| Kaneto, H; Rahman, AF; Takahashi, M | 1 |
| Hayaishi, O; Horiguchi, S; Hyodo, M; Ito, S; Minami, T; Uda, R | 1 |
| Lin, Q; Peng, Y; Willis, WD | 1 |
| Fonia, O; Gavish, M; Katz, Y; Liu, L; Pasternak, GW; Pick, CG; Weizman, A | 1 |
| Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M | 1 |
| Yaksh, TL; Yamamoto, T | 1 |
| Beitz, AJ; Mullet, MA; Williams, FG | 1 |
| Ito, S; Minami, T; Nishihara, I; Onaka, M | 1 |
| Archer, DP; Ewen, A; Froelich, J; Roth, SH; Samanani, N | 1 |
| Ishikawa, T; Yaksh, TL | 1 |
| Fields, HL; Pan, ZZ | 1 |
| Fields, HL; Roychowdhury, SM | 1 |
| Hao, JX; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
| Hammond, DL; Kaneko, M | 1 |
| Matsumoto, K; Nguyen, TT; Watanabe, H | 1 |
| Budai, D; Fields, HL | 1 |
| Dickenson, AH; Kerr, NC; Reeve, AJ | 1 |
| Goto, T | 1 |
| Cervero, F; Laird, JM; Schouenborg, J; Weng, HR | 1 |
| Budai, D; Fields, HL; Harasawa, I | 1 |
| Eguchi, N; Hayaishi, O; Ito, S; Kanaoka, Y; Minami, T; Nagata, A; Shirafuji, N; Tanaka, T; Urade, Y; Yoshida, N | 1 |
| Chiang, CY; Hu, JW; Kwan, CL; Sessle, BJ | 1 |
| Asai, T; Ikeda, H; Murase, K | 1 |
| Basu, A; Dickenson, AH; Kontinen, VK; Stanfa, LC | 1 |
| Hefferan, MP; Khandwala, H; Loomis, CW; Osmond, G | 1 |
| Mahmoudi, M; Zarrindast, MR | 1 |
| Nemmani, KV; Ramarao, P | 1 |
| De Koninck, Y; Henry, JL | 1 |
| Giordano, J | 1 |
| Edwards, M; Gent, JP; Goodchild, CS; Serrao, JM | 1 |
| Ji, CF; Li, CY; Zhu, LX | 1 |
| Aley, KO; Kulkarni, SK | 1 |
| Chen, ZQ; Xu, W; Yan, YS | 1 |
| Yaksh, TL | 1 |
| Wang, SK; Wang, YJ; Wu, J | 1 |
| Beyer, C; Komisaruk, BR; Roberts, LA | 1 |
| Ferrario, P; Hafner, B; Mantegazza, P; Tammiso, R; Zambotti, F; Zonta, N | 1 |
| Wang, SK; Wang, YJ | 1 |
| Drower, EJ; Hammond, DL | 1 |
| Feng, XC; Ye, WL | 1 |
| Fields, HL; Moreau, JL | 1 |
Other Studies
101 other study(ies) available for bicuculline and Pain
| Article | Year |
|---|---|
Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis.
Topics: Animals; Bicuculline; Colitis; Colon; Dextran Sulfate; Diazepam; Disease Models, Animal; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; Muscimol; Pain; Receptors, GABA-A | 2022 |
Bio-guided study of the antinociceptive, anti-inflammatory, and free-radical scavenging capacity of the leaves of Rhus virens Lindh. ex A. Gray and its possible mechanism of antinociception.
Topics: Adenosine Triphosphate; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Bicuculline; Edema; Glyburide; Hexanes; Mice; Naloxone; NG-Nitroarginine Methyl Ester; Pain; Plant Extracts; Plant Leaves; Rhus | 2023 |
Effects of GABAA receptors in nucleus cuneiformis on the cannabinoid antinociception using the formalin test.
Topics: Animals; Benzoxazines; Bicuculline; Cannabinoids; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Morpholines; Muscimol; Naphthalenes; Nociception; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, GABA-A | 2021 |
Evaluation of antinociceptive activity of Ilex dipyrena Wall. in mice.
Topics: Analgesics; Animals; Bicuculline; GABA-A Receptor Antagonists; Ilex; Mice, Inbred BALB C; Models, Animal; Naloxone; Narcotic Antagonists; Pain; Plant Extracts; Toxicity Tests, Acute | 2021 |
Ionic plasticity and pain: The loss of descending serotonergic fibers after spinal cord injury transforms how GABA affects pain.
Topics: Animals; Bicuculline; Capsaicin; Conditioning, Operant; GABA Antagonists; gamma-Aminobutyric Acid; K Cl- Cotransporters; Male; Neuronal Plasticity; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, GABA-A; Serotonergic Neurons; Serotonin Antagonists; Spinal Cord Injuries; Symporters | 2018 |
Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and "triptan" receptors: implications in migraine.
Topics: Animals; Arachidonic Acids; Bicuculline; Cannabinoid Receptor Agonists; Disease Models, Animal; Endocannabinoids; GABA-A Receptor Antagonists; Male; Microinjections; Nerve Fibers, Myelinated; Pain; Periaqueductal Gray; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Skin; Trigeminal Nuclei | 2013 |
Disruption of 5-HT2A receptor-PDZ protein interactions alleviates mechanical hypersensitivity in carrageenan-induced inflammation in rats.
Topics: Animals; Bicuculline; Carrageenan; Disks Large Homolog 4 Protein; Fluorobenzenes; Fluoxetine; Hyperalgesia; Inflammation; Injections; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Pain; Peptides; Piperidines; Posterior Horn Cells; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists | 2013 |
Glutamate/GABA balance in ACC modulates the nociceptive responses of vocalization: an expression of affective-motivational component of pain in guinea pigs.
Topics: Animals; Bicuculline; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Gyrus Cinguli; Homocysteine; Male; Microinjections; Muscimol; Pain; Time Factors; Vocalization, Animal | 2014 |
Association of antinociceptive action of botulinum toxin type A with GABA-A receptor.
Topics: Animals; Bicuculline; Botulinum Toxins, Type A; Disease Models, Animal; Drug Administration Routes; Formaldehyde; Hyperalgesia; Neurotoxins; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, GABA-A; Sciatica | 2014 |
Stress induces pain transition by potentiation of AMPA receptor phosphorylation.
Topics: Animals; Bicuculline; Biotinylation; GABA Antagonists; Male; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Phosphorylation; Receptors, AMPA; Social Dominance; Stress, Psychological; Synapses | 2014 |
The Pronociceptive Effect of Paradoxical Sleep Deprivation in Rats: Evidence for a Role of Descending Pain Modulation Mechanisms.
Topics: Animals; Bicuculline; Lidocaine; Male; Morphine; Motor Activity; Nociception; Pain; Pain Measurement; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Rats, Wistar; Sleep Deprivation | 2016 |
GABAergic neurons of the medial septum play a nodal role in facilitation of nociception-induced affect.
Topics: Animals; Behavior, Animal; Bicuculline; Formaldehyde; GABAergic Neurons; Gyrus Cinguli; Hippocampus; Nociception; Pain; Rats; Receptors, GABA-A; Septal Nuclei | 2015 |
GABA(A) Receptors in the Central Nucleus of the Amygdala Are Involved in Pain- and Itch-Related Responses.
Topics: Animals; Behavior, Animal; Bicuculline; Central Amygdaloid Nucleus; Disease Models, Animal; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Muscimol; Pain; Pruritus; Rats; Rats, Sprague-Dawley; Receptors, GABA-A | 2016 |
Protein Kinase C γ Interneurons Mediate C-fiber-induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber-induced Nociceptive Behavior.
Topics: Animals; Bicuculline; Capsaicin; Excitatory Amino Acid Antagonists; Hyperalgesia; Interneurons; Male; Mechanoreceptors; Nerve Fibers, Unmyelinated; Pain; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, GABA-B | 2016 |
Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain.
Topics: Analgesics; Animals; Bicuculline; Botulinum Toxins, Type A; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Functional Laterality; Hyperalgesia; Male; Naloxone; Pain; Pain Measurement; Rats; Rats, Wistar; Spinal Cord; Synaptosomal-Associated Protein 25 | 2016 |
GABAA receptors in the central nucleus of amygdala (CeA) affect on pain modulation.
Topics: Amygdala; Animals; Bicuculline; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Microinjections; Muscimol; Neural Inhibition; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Synaptic Transmission | 2008 |
Modulation of gamma-aminobutyric acid on painful sense in central nervous system of morphine-dependent rats.
Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Drug Administration Schedule; Electric Stimulation; Female; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Morphine; Morphine Dependence; Narcotics; Nucleus Accumbens; Pain; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Time Factors | 2008 |
Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat.
Topics: Action Potentials; Animals; Bicuculline; Blotting, Western; Carboxylic Acids; Electric Stimulation; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Immunohistochemistry; Indenes; Inhibitory Postsynaptic Potentials; K Cl- Cotransporters; Male; Membrane Potentials; Nerve Fibers; Neurons, Afferent; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord; Spinal Cord Injuries; Spinal Nerve Roots; Symporters; Synaptic Transmission | 2008 |
Intra-hippocampal tonic inhibition influences formalin pain-induced pyramidal cell suppression, but not excitation in dorsal field CA1 of rat.
Topics: Analysis of Variance; Animals; Bicuculline; Dendrites; Electric Stimulation; Electroencephalography; Electrophysiology; Evoked Potentials; Excitatory Postsynaptic Potentials; Extracellular Fluid; Formaldehyde; Hippocampus; Injections, Subcutaneous; Male; Neurons; Pain; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Reaction Time | 2008 |
Hypothalamospinal oxytocinergic antinociception is mediated by GABAergic and opiate neurons that reduce A-delta and C fiber primary afferent excitation of spinal cord cells.
Topics: Animals; Bicuculline; Efferent Pathways; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Narcotic Antagonists; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Inhibition; Neurons; Nociceptors; Opioid Peptides; Oxytocin; Pain; Posterior Horn Cells; Rats; Rats, Wistar; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission | 2009 |
Corticofugal outputs facilitate acute, but inhibit chronic pain in rats.
Topics: Analysis of Variance; Animals; Bicuculline; Chronic Disease; Disease Models, Animal; Freund's Adjuvant; Functional Laterality; GABA Agonists; GABA Antagonists; Hot Temperature; Male; Muscimol; Neural Pathways; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Spinothalamic Tracts; Thalamic Nuclei; Time Factors | 2009 |
Effects of systemic bicuculline or morphine on formalin-evoked pain-related behaviour and c-Fos expression in trigeminal nuclei after formalin injection into the lip or tongue in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Bicuculline; Formaldehyde; GABA Antagonists; Gene Expression; Genes, fos; Lip; Male; Morphine; Neurons; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Tongue; Trigeminal Ganglion; Trigeminal Nuclei | 2009 |
Opioidergic and GABAergic mechanisms in the rostral ventromedial medulla modulate the nociceptive response of vocalization in guinea pigs.
Topics: Analgesics, Opioid; Animals; Bicuculline; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Male; Medulla Oblongata; Morphine; Muscimol; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Vocalization, Animal | 2010 |
Opioid receptor internalization contributes to dermorphin-mediated antinociception.
Topics: Analgesics, Opioid; Animals; Bicuculline; Concanavalin A; Dynamins; Fluorescent Dyes; GABA-A Receptor Antagonists; Male; Microinjections; Naltrexone; Neurons; Opioid Peptides; Pain; Pain Measurement; Peptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu | 2010 |
Analgesia induced by 2- or 100-Hz electroacupuncture in the rat tail-flick test depends on the activation of different descending pain inhibitory mechanisms.
Topics: Adjuvants, Anesthesia; Adrenergic alpha-Antagonists; Analgesia; Anesthetics, Intravenous; Animals; Atropine; Baclofen; Bicuculline; Biophysics; Dioxanes; Disease Models, Animal; Electroacupuncture; GABA Agents; Male; Methysergide; Models, Biological; Multivariate Analysis; Naloxone; Narcotic Antagonists; Pain; Pain Management; Pain Measurement; Rats; Rats, Wistar; Reaction Time; Serotonin Antagonists; Tail; Thiopental; Time Factors | 2011 |
The effect of intra-locus coeruleus injection of 17beta-estradiol on inflammatory pain modulation in male rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Disease Models, Animal; Estradiol; Estrogen Antagonists; Estrogens; Formaldehyde; Fulvestrant; Inflammation; Locus Coeruleus; Male; Microinjections; Pain; Rats; Rats, Sprague-Dawley; Valine | 2010 |
T-type channels control the opioidergic descending analgesia at the low threshold-spiking GABAergic neurons in the periaqueductal gray.
Topics: Analgesics, Opioid; Animals; Bicuculline; Calcium Channels, T-Type; Female; GABA Antagonists; GABA-A Receptor Antagonists; Green Fluorescent Proteins; In Situ Hybridization, Fluorescence; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Mice, Transgenic; Microscopy, Confocal; Neurons; Pain; Pain Measurement; Periaqueductal Gray; Receptors, GABA-A; RNA Interference | 2010 |
Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice.
Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hot Temperature; Hyperalgesia; Injections; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Muscimol; Pain; Pain Threshold; Receptors, GABA; Receptors, Glycine; Taurine | 2010 |
Enhanced excitatory and reduced inhibitory synaptic transmission contribute to persistent pain-induced neuronal hyper-responsiveness in anterior cingulate cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Analysis of Variance; Animals; Bee Venoms; Bicuculline; Biophysics; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Gyrus Cinguli; Male; Neural Inhibition; Neurons; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Synaptic Transmission; Tetrodotoxin | 2010 |
Spike-train communities: finding groups of similar spike trains.
Topics: Action Potentials; Algorithms; Animals; Bicuculline; Cats; Cluster Analysis; Corpus Striatum; Electronic Data Processing; GABA-A Receptor Antagonists; Models, Neurological; Nerve Net; Neurons; Nonlinear Dynamics; Pain; Time Factors | 2011 |
Differential effects of mGluR7 and mGluR8 activation on pain-related synaptic activity in the amygdala.
Topics: Adjuvants, Immunologic; Amygdala; Animals; Arthritis; Benzhydryl Compounds; Bicuculline; Biophysics; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; GABA Antagonists; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Neurons; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Potentials | 2011 |
Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors.
Topics: Action Potentials; Animals; Arthritis, Experimental; Benzoates; Bicuculline; Disease Models, Animal; Electrophysiology; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Male; Methoxyhydroxyphenylglycol; Neurons; Pain; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, GABA-A; Receptors, Metabotropic Glutamate | 2011 |
In vivo patch-clamp recording from locus coeruleus neurones in the rat brainstem.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Inhibitory Postsynaptic Potentials; Locus Coeruleus; Male; Neurons; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 2012 |
Inhibitory control of nociceptive responses of trigeminal spinal nucleus cells by somatosensory corticofugal projection in rat.
Topics: Action Potentials; Afferent Pathways; Animals; Bicuculline; Biophysics; Capsaicin; Constriction; Disease Models, Animal; Electric Stimulation; Female; GABA-A Receptor Antagonists; Glutamic Acid; Glycine Agents; Hyperalgesia; Iontophoresis; Male; Neural Inhibition; Neuralgia; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Strychnine; Time Factors; Trigeminal Nucleus, Spinal | 2012 |
Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat.
Topics: Action Potentials; Amygdala; Animals; Bicuculline; Carrageenan; Chromones; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; GABA Antagonists; Gene Expression; Glycine; Male; Neural Inhibition; Neural Pathways; Neuronal Plasticity; Pain; Physical Stimulation; Prefrontal Cortex; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols | 2013 |
Cerebellar stimulation modulates the intensity of a visceral nociceptive reflex in the rat.
Topics: Animals; Bicuculline; Brain Mapping; Cerebellar Cortex; Cerebellum; Colon; Electric Stimulation; Electromyography; GABA Agonists; Homocysteine; Male; Muscle, Skeletal; Neural Pathways; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Rectum; Reflex; Stereotaxic Techniques | 2002 |
Somatic nociception activates NK1 receptors in the nucleus tractus solitarii to attenuate the baroreceptor cardiac reflex.
Topics: Animals; Baroreflex; Bicuculline; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Microinjections; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Neurokinin-1; Solitary Nucleus; Substance P | 2002 |
Trigeminal antinociception induced by bicuculline in the periaqueductal gray (PAG) is not affected by PAG P/Q-type calcium channel blockade in rat.
Topics: Animals; Bicuculline; Calcium Channel Blockers; Calcium Channels, P-Type; Calcium Channels, Q-Type; Dose-Response Relationship, Drug; Electrophysiology; Male; Microinjections; Migraine Disorders; Neural Inhibition; Neurons; Nociceptors; omega-Agatoxin IVA; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Trigeminal Caudal Nucleus | 2003 |
Bicuculline and strychnine suppress the mesencephalic locomotor region-induced inhibition of group III muscle afferent input to the dorsal horn.
Topics: Afferent Pathways; Animals; Bicuculline; Cats; Efferent Pathways; Female; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Locomotion; Male; Muscle, Skeletal; Neural Inhibition; Pain; Posterior Horn Cells; Receptors, GABA-A; Receptors, Glycine; Reflex; Regional Blood Flow; Spinal Nerve Roots; Strychnine; Synaptic Transmission; Tegmentum Mesencephali; Vasoconstriction | 2003 |
Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord.
Topics: Adrenergic alpha-Antagonists; Animals; Bicuculline; GABA Antagonists; Hyperalgesia; Joints; Male; Methysergide; Naloxone; Narcotic Antagonists; Pain; Pain Management; Physical Stimulation; Physical Therapy Modalities; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, GABA; Receptors, Opioid; Receptors, Serotonin; Serotonin Antagonists; Spinal Cord; Yohimbine | 2003 |
Effects of corticotropin-releasing factor on plasticity of optically recorded neuronal activity in the substantia gelatinosa of rat spinal cord slices.
Topics: Animals; Bicuculline; Corticotropin-Releasing Hormone; GABA Antagonists; Glycine Agents; Long-Term Potentiation; Long-Term Synaptic Depression; Neuronal Plasticity; Neurons; Organ Culture Techniques; Pain; Rats; Rats, Sprague-Dawley; Strychnine; Substantia Gelatinosa | 2003 |
Contribution of spinal inhibitory receptors in heterosegmental antinociception induced by noxious stimulation.
Topics: Animals; Bicuculline; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Electrodes, Implanted; Electromyography; GABA Antagonists; Glycine Agents; Male; Models, Neurological; Narcotic Antagonists; Neural Inhibition; Nucleus Accumbens; Organophosphorus Compounds; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Strychnine | 2003 |
Involvement of peripheral neuropeptide Y receptors in sympathetic modulation of acute cutaneous flare induced by intradermal capsaicin.
Topics: Animals; Arginine; Benzazepines; Bicuculline; Capsaicin; Foot; GABA Antagonists; Inflammation; Injections, Spinal; Laser-Doppler Flowmetry; Male; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Skin; Spinal Cord; Sympathectomy; Sympathetic Nervous System | 2004 |
Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn.
Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Female; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hyperalgesia; Neural Inhibition; Neural Pathways; Pain; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Spinal Cord Injuries; Touch; Wounds, Nonpenetrating | 2004 |
Corticothalamic modulation on formalin-induced change of VPM thalamic activities.
Topics: Animals; Bicuculline; Formaldehyde; GABA Agonists; GABA Antagonists; Male; Muscimol; Neural Pathways; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Ventral Thalamic Nuclei; Vibrissae | 2004 |
Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain.
Topics: Animals; Baclofen; Bicuculline; Calcitonin Gene-Related Peptide; gamma-Aminobutyric Acid; Ganglia, Spinal; Genetic Therapy; Genetic Vectors; Glutamate Decarboxylase; Hyperalgesia; Injections, Subcutaneous; Isoenzymes; Neurons; Pain; Rats; Simplexvirus; Spinal Cord Injuries; Tissue Distribution; Transduction, Genetic | 2004 |
Activation of 5-HT(1B/1D) receptor in the periaqueductal gray inhibits nociception.
Topics: Animals; Bicuculline; Electric Stimulation; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Inhibition; Pain; Pain Measurement; Periaqueductal Gray; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D | 2004 |
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats.
Topics: Analgesia; Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; Hyperalgesia; Hypnotics and Sedatives; Male; Microinjections; Pain; Pain Measurement; Periaqueductal Gray; Propofol; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord | 2004 |
Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice.
Topics: Acetic Acid; Analgesics; Animals; Anticonvulsants; Bicuculline; Female; Fruit; Hot Temperature; Male; Mice; Mice, Inbred BALB C; Pain; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures; Tetrapleura | 2005 |
Contribution of the ventromedial hypothalamus to generation of the affective dimension of pain.
Topics: Affect; Animals; Bicuculline; Conditioning, Classical; Electric Stimulation; Electroshock; Fear; GABA Agonists; GABA Antagonists; Hindlimb; Hypothalamus; Male; Muscimol; Pain; Rats; Rats, Long-Evans; Receptors, GABA-A; Reflex; Spinal Cord; Tail; Ventromedial Hypothalamic Nucleus; Vocalization, Animal | 2006 |
GABAA-Receptor blockade reverses the injury-induced sensitization of nociceptor-specific (NS) neurons in the spinal dorsal horn of the rat.
Topics: Action Potentials; Animals; Bicuculline; Capsaicin; Electrophysiology; Female; GABA Antagonists; GABA-A Receptor Antagonists; Male; Mustard Plant; Neurons; Nociceptors; Pain; Physical Stimulation; Picrotoxin; Plant Oils; Posterior Horn Cells; Rats; Rats, Wistar; Stimulation, Chemical | 2006 |
Interactions between opioid-peptides-containing pathways and GABA(A)-receptors-mediated systems modulate panic-like-induced behaviors elicited by electric and chemical stimulation of the inferior colliculus.
Topics: Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Drug Interactions; Electric Stimulation; Freezing Reaction, Cataleptic; GABA Antagonists; Inferior Colliculi; Male; Morphine; Naloxone; Narcotic Antagonists; Neural Pathways; Opioid Peptides; Pain; Rats; Rats, Wistar; Receptors, GABA-A; Stimulation, Chemical | 2006 |
On the mechanism of carbamazepine-induced antinociception in the formalin test.
Topics: Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Formaldehyde; GABA Antagonists; Male; Mice; Organophosphorus Compounds; Pain; Pain Measurement; Prazosin; Yohimbine | 2006 |
Corticofugal output from the primary somatosensory cortex selectively modulates innocuous and noxious inputs in the rat spinothalamic system.
Topics: Animals; Bicuculline; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; Hindlimb; Homocysteine; Hot Temperature; Male; Microinjections; Muscimol; Neural Pathways; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Somatosensory Cortex; Spinothalamic Tracts; Thalamic Nuclei | 2006 |
[Effect of morphine on dorsal horn projection neurons in neuropathic pain rats].
Topics: Analgesics, Opioid; Animals; Bicuculline; Electrophysiology; Hyperesthesia; Male; Morphine; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2006 |
GABAA but not GABAB receptors in the rostral anterior cingulate cortex selectively modulate pain-induced escape/avoidance behavior.
Topics: Animals; Avoidance Learning; Baclofen; Bicuculline; Escape Reaction; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Gyrus Cinguli; Male; Microinjections; Muscimol; Pain; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B | 2007 |
Involvement of GABA A receptor-associated chloride channels in the peripheral antinociceptive effect induced by GABA A receptor agonist muscimol.
Topics: Analysis of Variance; Animals; Bicuculline; Chloride Channels; Dinoprostone; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; Injections, Subcutaneous; Male; Muscimol; Pain; Pain Measurement; Picrotoxin; Potassium Channel Blockers; Potassium Channels; Pressure; Rats; Rats, Wistar; Receptors, GABA-A | 2007 |
In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on the modulation of pain in mice.
Topics: Analgesics; Animals; Benzamides; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Humans; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Tachykinins; Tropanes | 2008 |
GABAergic mechanisms in antinociception.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Analgesics; Animals; Baclofen; Bicuculline; Central Nervous System; gamma-Aminobutyric Acid; Isoxazoles; Mice; Muscimol; Pain; Rats; Stereoisomerism; Substance P; Synaptic Transmission; Vigabatrin | 1984 |
[Pharmaco-ethological study of analgesia induced by intraspecies fighting behavior].
Topics: Aggression; Analgesia; Animals; Behavior, Animal; Bicuculline; Conflict, Psychological; Dominance-Subordination; Humans; Male; Mice; Mice, Inbred C57BL; Naloxone; Pain; Sensory Thresholds; Time Factors | 1984 |
Role of GABAergic systems in the development of morphine tolerance in formalin-treated mice.
Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; GABA Agonists; GABA Antagonists; Male; Mice; Mice, Inbred Strains; Morphine; Muscimol; Pain; Pain Measurement; Receptors, GABA | 1995 |
Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice.
Topics: Animals; Bicuculline; Dinoprostone; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Pain; Prostaglandin D2; Strychnine | 1994 |
Glycine and GABAA antagonists reduce the inhibition of primate spinothalamic tract neurons produced by stimulation in periaqueductal gray.
Topics: Animals; Bicuculline; Brain Mapping; Dose-Response Relationship, Drug; Electric Stimulation; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Hot Temperature; Macaca fascicularis; Male; Muscimol; Neurons; Pain; Periaqueductal Gray; Physical Stimulation; Spinal Cord; Strychnine; Thalamus | 1994 |
Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity.
Topics: Animals; Bicuculline; Binding, Competitive; Brain; Cell Membrane; Cerebral Ventricles; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraventricular; Injections, Spinal; Isoquinolines; Kinetics; Male; Mice; Mice, Inbred Strains; Muscimol; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures; Spinal Cord; Substance Withdrawal Syndrome | 1994 |
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail | 1993 |
Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801.
Topics: Animals; Bicuculline; Dizocilpine Maleate; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Hot Temperature; Injections, Spinal; Male; N-Methylaspartate; Nerve Crush; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Strychnine | 1993 |
Basal release of Met-enkephalin and neurotensin in the ventrolateral periaqueductal gray matter of the rat: a microdialysis study of antinociceptive circuits.
Topics: Animals; Basal Metabolism; Bicuculline; Enkephalin, Methionine; Feedback; GABA Antagonists; Male; Microdialysis; Morphine; Neural Pathways; Neurotensin; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley | 1995 |
Involvement of glutamate receptors in strychnine- and bicuculline-induced allodynia in conscious mice.
Topics: Animals; Bicuculline; GABA Antagonists; Glycine Agents; Male; Mice; Nitric Oxide; Pain; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Strychnine | 1996 |
Thiopentone induced enhancement of somatic motor responses to noxious stimulation: influence of GABAA receptor modulation.
Topics: Animals; Bicuculline; GABA Modulators; Hypnotics and Sedatives; Male; Muscimol; Pain; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thiopental | 1996 |
[Concurrent characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABAA receptor antagonists].
Topics: Amino Acids; Animals; Bicuculline; GABA Antagonists; Glycine Agents; Injections, Spinal; Male; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Strychnine; Touch | 1996 |
Endogenous opioid-mediated inhibition of putative pain-modulating neurons in rat rostral ventromedial medulla.
Topics: Animals; Bicuculline; Brain Mapping; Enkephalins; Evoked Potentials; Male; Medulla Oblongata; Morphine; Naloxone; Nerve Endings; Neurons; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reflex | 1996 |
Endogenous opioids acting at a medullary mu-opioid receptor contribute to the behavioral antinociception produced by GABA antagonism in the midbrain periaqueductal gray.
Topics: Animals; Bicuculline; Brain Mapping; GABA Antagonists; Male; Medulla Oblongata; Mesencephalon; Microinjections; Models, Neurological; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Time Factors | 1996 |
Nociceptin or antinociceptin: potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-2 Receptor Antagonists; Analysis of Variance; Animals; Bicuculline; Electromyography; Electroshock; Female; GABA-A Receptor Antagonists; Imidazoles; Injections, Spinal; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Nerve Fibers; Nociceptin; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord; Sural Nerve | 1996 |
Role of spinal gamma-aminobutyric acidA receptors in formalin-induced nociception in the rat.
Topics: Animals; Bicuculline; Formaldehyde; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Injections, Spinal; Isonicotinic Acids; Male; Pain; Premedication; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord | 1997 |
Involvement of supraspinal GABA-ergic systems in clonidine-induced antinociception in the tail-pinch test in mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Animals; Baclofen; Bicuculline; Clonidine; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Pain; Picrotoxin; Receptors, GABA; Tail | 1997 |
Endogenous opioid peptides acting at mu-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Bicuculline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; GABA Antagonists; Hot Temperature; Iontophoresis; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Peptide Fragments; Peptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Tail | 1998 |
Spinal effects of bicuculline: modulation of an allodynia-like state by an A1-receptor agonist, morphine, and an NMDA-receptor antagonist.
Topics: Adenosine; Animals; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Kynurenic Acid; Male; Morphine; Naloxone; Nerve Fibers; Neurons; Pain; Physical Stimulation; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Touch | 1998 |
[Preemptive analgesia].
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Formaldehyde; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Neurotransmitter Agents; Pain; Pain Measurement; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Strychnine | 1997 |
GABAA receptor blockade inhibits A beta fibre evoked wind-up in the arthritic rat.
Topics: Animals; Arthritis; Bicuculline; Decerebrate State; Dose-Response Relationship, Drug; Electromyography; Female; GABA Antagonists; GABA-A Receptor Antagonists; Hindlimb; Knee Joint; Male; Nerve Fibers, Myelinated; Pain; Rats; Rats, Wistar; Touch | 1998 |
Midbrain periaqueductal gray (PAG) inhibits nociceptive inputs to sacral dorsal horn nociceptive neurons through alpha2-adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bicuculline; Clonidine; Excitatory Amino Acids; Hot Temperature; Idazoxan; Iontophoresis; Male; Methoxamine; Neural Inhibition; Neurons; Norepinephrine; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spinal Cord; Synapses | 1998 |
Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice.
Topics: Anesthesia; Animals; Bicuculline; Central Nervous System; Dinoprost; Dinoprostone; GABA Antagonists; Gene Targeting; Hydantoins; Hyperalgesia; Immunohistochemistry; Intramolecular Oxidoreductases; Lipocalins; Mice; Mice, Knockout; Molecular Sequence Data; Pain; Prostaglandin D2; Receptors, Prostaglandin | 1999 |
Effects of GABA receptor antagonist on trigeminal caudalis nociceptive neurons in normal and neonatally capsaicin-treated rats.
Topics: Animals; Animals, Newborn; Baclofen; Bicuculline; Brain Mapping; Capsaicin; Functional Laterality; GABA Antagonists; GABA-A Receptor Antagonists; Male; Medulla Oblongata; Microinjections; Neuronal Plasticity; Neurons; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Touch; Trigeminal Nerve | 1999 |
Robust changes of afferent-induced excitation in the rat spinal dorsal horn after conditioning high-frequency stimulation.
Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Chlorides; Conditioning, Psychological; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine Agents; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neuronal Plasticity; Optics and Photonics; Pain; Posterior Horn Cells; Potassium; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Strychnine | 2000 |
Electrophysiologic evidence for increased endogenous gabaergic but not glycinergic inhibitory tone in the rat spinal nerve ligation model of neuropathy.
Topics: Animals; Bicuculline; Cold Temperature; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Male; Nerve Fibers, Myelinated; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Strychnine | 2001 |
Coadministration of intrathecal strychnine and bicuculline effects synergistic allodynia in the rat: an isobolographic analysis.
Topics: Analysis of Variance; Animals; Bicuculline; Convulsants; Drug Synergism; Injections, Spinal; Male; Pain; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Strychnine | 2001 |
GABA mechanisms and antinociception in mice with ligated sciatic nerve.
Topics: Animals; Baclofen; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Antagonists; Ligation; Male; Mice; Mice, Inbred Strains; Morphine; Muscimol; Naloxone; Organophosphorus Compounds; Pain; Pain Measurement; Sciatic Nerve | 2001 |
Role of benzodiazepine-GABAA receptor complex in attenuation of U-50,488H-induced analgesia and inhibition of tolerance to its analgesia by ginseng total saponin in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Tolerance; Drugs, Chinese Herbal; Flumazenil; Ginsenosides; Injections, Intraperitoneal; Male; Mice; Pain; Pain Threshold; Panax; Picrotoxin; Receptors, GABA-A; Receptors, Opioid, kappa; Saponins; Tail | 2002 |
Peripheral vibration causes an adenosine-mediated postsynaptic inhibitory potential in dorsal horn neurons of the cat spinal cord.
Topics: Adenosine; Adenosine Monophosphate; Animals; Bicuculline; Cats; Evoked Potentials; Iontophoresis; Membrane Potentials; Naloxone; Neurons; Pain; Physical Stimulation; Purinergic Antagonists; Spinal Cord; Strychnine; Synapses; Theophylline; Vibration | 1992 |
Analgesic profile of centrally administered 2-methylserotonin against acute pain in rats.
Topics: Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Spinal; Ketanserin; Male; Mianserin; Motor Activity; Naloxone; Nociceptors; Pain; Rats; Rats, Inbred Strains; Receptors, Serotonin; Respiration; Serotonin; Serotonin Antagonists; Tropanes | 1991 |
On the mechanism by which midazolam causes spinally mediated analgesia.
Topics: Analgesia, Epidural; Animals; Bicuculline; Cyclazocine; Dose-Response Relationship, Drug; Electric Stimulation; Ethylketocyclazocine; Fentanyl; Flumazenil; Male; Midazolam; Pain; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sensory Thresholds | 1990 |
Dual action of substance P in nociception and pain modulation at spinal level.
Topics: Animals; Bicuculline; Efferent Pathways; Naloxone; Neurons; Nociceptors; Pain; Rats; Spinal Cord; Substance P | 1987 |
GABAergic agents-induced antinociceptive effect in mice.
Topics: Analgesics; Animals; Baclofen; Bicuculline; Female; gamma-Aminobutyric Acid; Male; Mice; Morphine; Muscimol; Pain; Picrotoxin; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds; Valproic Acid | 1989 |
[Effect of electroacupuncture on nociceptive responses after topical application of bicuculline in the rat].
Topics: Acupuncture Analgesia; Animals; Bicuculline; Efferent Pathways; Electroacupuncture; Male; Nociceptors; Pain; Rats; Sensory Thresholds; Somatosensory Cortex | 1989 |
Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists.
Topics: Analgesics; Animals; Autonomic Nervous System Diseases; Bicuculline; Blood Pressure; Dose-Response Relationship, Drug; Male; Pain; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Spinal Cord; Strychnine | 1989 |
Effects of bicuculline on the changes of pain threshold and some neurotransmitters of brain in rats induced by EAA.
Topics: Acupuncture Therapy; Animals; Bicuculline; Brain; Electric Stimulation; Female; Male; Medulla Oblongata; Neurotransmitter Agents; Pain; Pons; Rats; Receptors, GABA-A; Sensory Thresholds | 1988 |
Nociceptive responses to altered GABAergic activity at the spinal cord.
Topics: Animals; Bicuculline; Female; gamma-Aminobutyric Acid; Injections, Spinal; Motor Activity; Muscimol; Pain; Pain Measurement; Physical Stimulation; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sensory Thresholds; Tail; Vocalization, Animal | 1986 |
Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.
Topics: Animals; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Flumazenil; Injections, Intraventricular; Male; Morphine; Pain; Rats; Rats, Inbred Strains | 1986 |
[Effects of intraperitoneal injection of bicuculline or atropine on electro-acupuncture analgesic effect and the changes in the brain noradrenaline content in rats].
Topics: Acupuncture Therapy; Animals; Atropine; Bicuculline; Brain; Electric Stimulation Therapy; Injections, Intraperitoneal; Male; Norepinephrine; Pain; Rats; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation | 1988 |
GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Oxazoles; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds | 1988 |
[Potentiation of acupuncture analgesia by GABA in the dorsal raphe nucleus].
Topics: 3-Mercaptopropionic Acid; Acupuncture Therapy; Animals; Bicuculline; Electric Stimulation Therapy; gamma-Aminobutyric Acid; Male; Muscimol; Nipecotic Acids; Pain; Raphe Nuclei; Rats; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation | 1986 |
Evidence for GABA involvement in midbrain control of medullary neurons that modulate nociceptive transmission.
Topics: Action Potentials; Animals; Bicuculline; gamma-Aminobutyric Acid; Male; Medulla Oblongata; Morphine; Muscimol; Neural Pathways; Pain; Pain Measurement; Periaqueductal Gray; Picrotoxin; Rats; Rats, Inbred Strains | 1986 |