Page last updated: 2024-08-21

bicuculline and Pain

bicuculline has been researched along with Pain in 101 studies

Research

Studies (101)

Timeframe	Studies, this research(%)	All Research%
pre-1990	13 (12.87)	18.7374
1990's	25 (24.75)	18.2507
2000's	35 (34.65)	29.6817
2010's	24 (23.76)	24.3611
2020's	4 (3.96)	2.80

Authors

Authors	Studies
Gold, MS; Loeza-Alcocer, E	1
Flores-Murrieta, FJ; Gonzalez-Cortazar, M; Herrera-Ruiz, ML; Juárez-Aragón, MC; Molina-Cabrera, J; Montiel-Ruiz, RM; Vargas-Ruiz, R; Zamilpa, A	1
Chen, J; Hasanein, P; Komaki, A; Yari, S	1
Ahmad, S; Ahn, MJ; Ali, A; Faheem, M; Khalil, AAK; Nasir, A; Nazir, N; Nisar, M; Sajjad, W; Shah, SMM; Shah, SWA; Shoaib, M; Subhan, F	1
Grau, JW; Huang, YJ	1
Akerman, S; Goadsby, PJ; Holland, PR; Lasalandra, MP	1
Aissouni, Y; Chalus, M; Courteix, C; Dupuis, A; Eschalier, A; Hernández, A; Marin, P; Pelissier, T; Pichon, X; Privat, AM; Wattiez, AS	1
Coutinho, MR; Ferreira, MD; Menescal-de-Oliveira, L; Zugaib, J	1
Bach-Rojecky, L; Drinovac, V; Lacković, Z	1
Fang, H; Furmanski, O; Huganir, RL; Johns, RA; Li, C; Liu, S; Skinner, J; Tao, F; Xing, Y; Yang, Y; Zhang, Y	1
Arase, M; Bertolini, JF; Fischer, L; Lima, MMS; Pontarolla, FM; Tobaldini, G; Tomim, DH	1
Ang, ST; Foo, FC; Khanna, S; Lee, AT; Low, CM; Ng, L	1
Chen, L; Dong, Z; Han, H; Tan, T; Wang, W	1
Artola, A; Bourgois, N; Dallel, R; Peirs, C	1
Bach-Rojecky, L; Drinovac Vlah, V; Lacković, Z	1
Hasanein, P; Javanmardi, K; Mirazi, N	1
Li, X; Xu, MY; Xu, Y	1
Lu, Y; Xiong, L; Yang, J; Zheng, J; Zimmermann, M	1
Khanna, S; Zheng, F	1
Condés-Lara, M; López-Hidalgo, M; Martínez-Lorenzana, G; Rodríguez-Jiménez, J; Rojas-Piloni, G	1
Luo, F; Wang, JY; Wang, N	1
Abe, T; Kobayashi, M; Satoh, F; Sugiyo, S; Takemura, M; Uehashi, D; Yonehara, N	1
Coutinho, MR; da Silva, LF; Menescal-de-Oliveira, L	1
Aicher, SA; Arttamangkul, S; Bobeck, EN; Hegarty, DM; Ingram, SL; Macey, TA; Morgan, MM	1
Prado, WA; Silva, JR; Silva, ML	1
Janahmadi, M; Javan, M; Khakpay, R; Semnanian, S	1
Choi, EJ; Kim, JH; Lee, CJ; Park, C; Shin, HS; Yoon, BE	1
Lee, IO; Lim, ES	1
An, YY; Cao, FL; Chen, J; Gao, CY; Gong, KR; He, Y; Li, H; Lin, Q; Wang, DD; Zhang, FK	1
Humphries, MD	1
Maione, S; Neugebauer, V; Palazzo, E; Ren, W	1
Ji, G; Neugebauer, V	1
Furue, H; Hur, SW; Imoto, K; Kase, D; Kawamata, M; Kim, SJ; Pickering, AE; Sugiyama, D	1
Malmierca, E; Martin, YB; Nuñez, A	1
Boccella, S; De Chiaro, M; de Novellis, V; Gatta, L; Giordano, C; Guida, F; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Siniscalco, D; Vita, D	1
Saab, CY; Willis, WD	1
Boscan, P; Kasparov, S; Paton, JF	1
Bartsch, T; Goadsby, PJ; Knight, YE	2
Degtyarenko, AM; Kaufman, MP	1
Radhakrishnan, R; Rohlwing, JJ; Skyba, DA; Sluka, KA; Wright, A	1
Ikeda, H; Kusudo, K; Murase, K; Ryu, PD	1
Gear, RW; Levine, JD; Quang, P; Tambeli, CH	1
Fang, L; Lin, Q; Ren, Y; Wang, J; Willis, WD; Zou, X	1
Drew, GM; Duggan, AW; Siddall, PJ	1
Bae, YC; Cho, JH; Choi, BJ; Choi, IS; Jung, SC; Kim, JH; Lee, MG; Shin, HC	1
Fink, DJ; Glorioso, JC; Hao, S; Huang, S; Liu, J; Mata, M; Wolfe, D	1
Cao, JL; Dai, TJ; Wang, QY; Zeng, YM	1
Ojewole, JA	1
Borszcz, GS	1
Cervero, F; Garcia-Nicas, E; Laird, JM	1
Calvo, F; Coimbra, NC	1
Hossein-Abad, AA; Sahebgharani, M; Zarrindast, MR	1
Chalus, M; Lopez-Avila, A; Molat, JL; Monconduit, L; Villanueva, L	1
Cao, DQ; Chang, YT; Chen, YP; Tan, CH; Xu, JM	1
Fuchs, PN; LaGraize, SC	1
Castro, M; Duarte, I; Francischi, J; Pacheco, D; Perez, A; Reis, G	1
Chen, Q; Dong, L; Fu, CY; Ni, JM; Wang, R; Zhao, YL	1
Sawynok, J	1
Ignatov, IuD; Petrova, IuV; Poshivalov, VP	1
Kaneto, H; Rahman, AF; Takahashi, M	1
Hayaishi, O; Horiguchi, S; Hyodo, M; Ito, S; Minami, T; Uda, R	1
Lin, Q; Peng, Y; Willis, WD	1
Fonia, O; Gavish, M; Katz, Y; Liu, L; Pasternak, GW; Pick, CG; Weizman, A	1
Brusa, L; D'Amore, A; Lorenzini, P; Massotti, M	1
Yaksh, TL; Yamamoto, T	1
Beitz, AJ; Mullet, MA; Williams, FG	1
Ito, S; Minami, T; Nishihara, I; Onaka, M	1
Archer, DP; Ewen, A; Froelich, J; Roth, SH; Samanani, N	1
Ishikawa, T; Yaksh, TL	1
Fields, HL; Pan, ZZ	1
Fields, HL; Roychowdhury, SM	1
Hao, JX; Wiesenfeld-Hallin, Z; Xu, XJ	1
Hammond, DL; Kaneko, M	1
Matsumoto, K; Nguyen, TT; Watanabe, H	1
Budai, D; Fields, HL	1
Dickenson, AH; Kerr, NC; Reeve, AJ	1
Goto, T	1
Cervero, F; Laird, JM; Schouenborg, J; Weng, HR	1
Budai, D; Fields, HL; Harasawa, I	1
Eguchi, N; Hayaishi, O; Ito, S; Kanaoka, Y; Minami, T; Nagata, A; Shirafuji, N; Tanaka, T; Urade, Y; Yoshida, N	1
Chiang, CY; Hu, JW; Kwan, CL; Sessle, BJ	1
Asai, T; Ikeda, H; Murase, K	1
Basu, A; Dickenson, AH; Kontinen, VK; Stanfa, LC	1
Hefferan, MP; Khandwala, H; Loomis, CW; Osmond, G	1
Mahmoudi, M; Zarrindast, MR	1
Nemmani, KV; Ramarao, P	1
De Koninck, Y; Henry, JL	1
Giordano, J	1
Edwards, M; Gent, JP; Goodchild, CS; Serrao, JM	1
Ji, CF; Li, CY; Zhu, LX	1
Aley, KO; Kulkarni, SK	1
Chen, ZQ; Xu, W; Yan, YS	1
Yaksh, TL	1
Wang, SK; Wang, YJ; Wu, J	1
Beyer, C; Komisaruk, BR; Roberts, LA	1
Ferrario, P; Hafner, B; Mantegazza, P; Tammiso, R; Zambotti, F; Zonta, N	1
Wang, SK; Wang, YJ	1
Drower, EJ; Hammond, DL	1
Feng, XC; Ye, WL	1
Fields, HL; Moreau, JL	1

Other Studies

101 other study(ies) available for bicuculline and Pain

Article	Year
Peripheral GABAA receptor signaling contributes to visceral hypersensitivity in a mouse model of colitis. Pain, 2022, 07-01, Volume: 163, Issue:7 Topics: Animals; Bicuculline; Colitis; Colon; Dextran Sulfate; Diazepam; Disease Models, Animal; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; Muscimol; Pain; Receptors, GABA-A	2022
Bio-guided study of the antinociceptive, anti-inflammatory, and free-radical scavenging capacity of the leaves of Rhus virens Lindh. ex A. Gray and its possible mechanism of antinociception. Journal of ethnopharmacology, 2023, Jan-10, Volume: 300 Topics: Adenosine Triphosphate; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Bicuculline; Edema; Glyburide; Hexanes; Mice; Naloxone; NG-Nitroarginine Methyl Ester; Pain; Plant Extracts; Plant Leaves; Rhus	2023
Effects of GABAA receptors in nucleus cuneiformis on the cannabinoid antinociception using the formalin test. Psychopharmacology, 2021, Volume: 238, Issue:6 Topics: Animals; Benzoxazines; Bicuculline; Cannabinoids; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Morpholines; Muscimol; Naphthalenes; Nociception; Pain; Pain Measurement; Rats; Rats, Wistar; Receptors, GABA-A	2021
Evaluation of antinociceptive activity of Ilex dipyrena Wall. in mice. BMC complementary medicine and therapies, 2021, Jul-01, Volume: 21, Issue:1 Topics: Analgesics; Animals; Bicuculline; GABA-A Receptor Antagonists; Ilex; Mice, Inbred BALB C; Models, Animal; Naloxone; Narcotic Antagonists; Pain; Plant Extracts; Toxicity Tests, Acute	2021
Ionic plasticity and pain: The loss of descending serotonergic fibers after spinal cord injury transforms how GABA affects pain. Experimental neurology, 2018, Volume: 306 Topics: Animals; Bicuculline; Capsaicin; Conditioning, Operant; GABA Antagonists; gamma-Aminobutyric Acid; K Cl- Cotransporters; Male; Neuronal Plasticity; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, GABA-A; Serotonergic Neurons; Serotonin Antagonists; Spinal Cord Injuries; Symporters	2018
Endocannabinoids in the brainstem modulate dural trigeminovascular nociceptive traffic via CB1 and "triptan" receptors: implications in migraine. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, Sep-11, Volume: 33, Issue:37 Topics: Animals; Arachidonic Acids; Bicuculline; Cannabinoid Receptor Agonists; Disease Models, Animal; Endocannabinoids; GABA-A Receptor Antagonists; Male; Microinjections; Nerve Fibers, Myelinated; Pain; Periaqueductal Gray; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Serotonin; Serotonin Agents; Serotonin Antagonists; Skin; Trigeminal Nuclei	2013
Disruption of 5-HT2A receptor-PDZ protein interactions alleviates mechanical hypersensitivity in carrageenan-induced inflammation in rats. PloS one, 2013, Volume: 8, Issue:9 Topics: Animals; Bicuculline; Carrageenan; Disks Large Homolog 4 Protein; Fluorobenzenes; Fluoxetine; Hyperalgesia; Inflammation; Injections; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Pain; Peptides; Piperidines; Posterior Horn Cells; Protein Binding; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Serotonin 5-HT2 Receptor Antagonists	2013
Glutamate/GABA balance in ACC modulates the nociceptive responses of vocalization: an expression of affective-motivational component of pain in guinea pigs. Physiology & behavior, 2014, Mar-14, Volume: 126 Topics: Animals; Bicuculline; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; GABA Agents; gamma-Aminobutyric Acid; Glutamic Acid; Guinea Pigs; Gyrus Cinguli; Homocysteine; Male; Microinjections; Muscimol; Pain; Time Factors; Vocalization, Animal	2014
Association of antinociceptive action of botulinum toxin type A with GABA-A receptor. Journal of neural transmission (Vienna, Austria : 1996), 2014, Volume: 121, Issue:6 Topics: Animals; Bicuculline; Botulinum Toxins, Type A; Disease Models, Animal; Drug Administration Routes; Formaldehyde; Hyperalgesia; Neurotoxins; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, GABA-A; Sciatica	2014
Stress induces pain transition by potentiation of AMPA receptor phosphorylation. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, Oct-08, Volume: 34, Issue:41 Topics: Animals; Bicuculline; Biotinylation; GABA Antagonists; Male; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Phosphorylation; Receptors, AMPA; Social Dominance; Stress, Psychological; Synapses	2014
The Pronociceptive Effect of Paradoxical Sleep Deprivation in Rats: Evidence for a Role of Descending Pain Modulation Mechanisms. Molecular neurobiology, 2016, Volume: 53, Issue:3 Topics: Animals; Bicuculline; Lidocaine; Male; Morphine; Motor Activity; Nociception; Pain; Pain Measurement; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Rats, Wistar; Sleep Deprivation	2016
GABAergic neurons of the medial septum play a nodal role in facilitation of nociception-induced affect. Scientific reports, 2015, Oct-21, Volume: 5 Topics: Animals; Behavior, Animal; Bicuculline; Formaldehyde; GABAergic Neurons; Gyrus Cinguli; Hippocampus; Nociception; Pain; Rats; Receptors, GABA-A; Septal Nuclei	2015
GABA(A) Receptors in the Central Nucleus of the Amygdala Are Involved in Pain- and Itch-Related Responses. The journal of pain, 2016, Volume: 17, Issue:2 Topics: Animals; Behavior, Animal; Bicuculline; Central Amygdaloid Nucleus; Disease Models, Animal; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Male; Muscimol; Pain; Pruritus; Rats; Rats, Sprague-Dawley; Receptors, GABA-A	2016
Protein Kinase C γ Interneurons Mediate C-fiber-induced Orofacial Secondary Static Mechanical Allodynia, but Not C-fiber-induced Nociceptive Behavior. Anesthesiology, 2016, Volume: 124, Issue:5 Topics: Animals; Bicuculline; Capsaicin; Excitatory Amino Acid Antagonists; Hyperalgesia; Interneurons; Male; Mechanoreceptors; Nerve Fibers, Unmyelinated; Pain; Phosphorylation; Posterior Horn Cells; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, GABA-B	2016
Antinociceptive action of botulinum toxin type A in carrageenan-induced mirror pain. Journal of neural transmission (Vienna, Austria : 1996), 2016, Volume: 123, Issue:12 Topics: Analgesics; Animals; Bicuculline; Botulinum Toxins, Type A; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Functional Laterality; Hyperalgesia; Male; Naloxone; Pain; Pain Measurement; Rats; Rats, Wistar; Spinal Cord; Synaptosomal-Associated Protein 25	2016
GABAA receptors in the central nucleus of amygdala (CeA) affect on pain modulation. Brain research, 2008, Nov-19, Volume: 1241 Topics: Amygdala; Animals; Bicuculline; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Male; Microinjections; Muscimol; Neural Inhibition; Nociceptors; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Synaptic Transmission	2008
Modulation of gamma-aminobutyric acid on painful sense in central nervous system of morphine-dependent rats. Neuroscience bulletin, 2008, Volume: 24, Issue:5 Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Drug Administration Schedule; Electric Stimulation; Female; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraventricular; Male; Morphine; Morphine Dependence; Narcotics; Nucleus Accumbens; Pain; Pain Threshold; Rats; Rats, Wistar; Reaction Time; Time Factors	2008
Spinal cord injury-induced attenuation of GABAergic inhibition in spinal dorsal horn circuits is associated with down-regulation of the chloride transporter KCC2 in rat. The Journal of physiology, 2008, Dec-01, Volume: 586, Issue:23 Topics: Action Potentials; Animals; Bicuculline; Blotting, Western; Carboxylic Acids; Electric Stimulation; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Immunohistochemistry; Indenes; Inhibitory Postsynaptic Potentials; K Cl- Cotransporters; Male; Membrane Potentials; Nerve Fibers; Neurons, Afferent; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord; Spinal Cord Injuries; Spinal Nerve Roots; Symporters; Synaptic Transmission	2008
Intra-hippocampal tonic inhibition influences formalin pain-induced pyramidal cell suppression, but not excitation in dorsal field CA1 of rat. Brain research bulletin, 2008, Dec-16, Volume: 77, Issue:6 Topics: Analysis of Variance; Animals; Bicuculline; Dendrites; Electric Stimulation; Electroencephalography; Electrophysiology; Evoked Potentials; Excitatory Postsynaptic Potentials; Extracellular Fluid; Formaldehyde; Hippocampus; Injections, Subcutaneous; Male; Neurons; Pain; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Reaction Time	2008
Hypothalamospinal oxytocinergic antinociception is mediated by GABAergic and opiate neurons that reduce A-delta and C fiber primary afferent excitation of spinal cord cells. Brain research, 2009, Jan-09, Volume: 1247 Topics: Animals; Bicuculline; Efferent Pathways; Electric Stimulation; GABA Antagonists; gamma-Aminobutyric Acid; Hypothalamus; Narcotic Antagonists; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Inhibition; Neurons; Nociceptors; Opioid Peptides; Oxytocin; Pain; Posterior Horn Cells; Rats; Rats, Wistar; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission	2009
Corticofugal outputs facilitate acute, but inhibit chronic pain in rats. Pain, 2009, Volume: 142, Issue:1-2 Topics: Analysis of Variance; Animals; Bicuculline; Chronic Disease; Disease Models, Animal; Freund's Adjuvant; Functional Laterality; GABA Agonists; GABA Antagonists; Hot Temperature; Male; Muscimol; Neural Pathways; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Spinothalamic Tracts; Thalamic Nuclei; Time Factors	2009
Effects of systemic bicuculline or morphine on formalin-evoked pain-related behaviour and c-Fos expression in trigeminal nuclei after formalin injection into the lip or tongue in rats. Experimental brain research, 2009, Volume: 196, Issue:2 Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Bicuculline; Formaldehyde; GABA Antagonists; Gene Expression; Genes, fos; Lip; Male; Morphine; Neurons; Pain; Pain Measurement; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Tongue; Trigeminal Ganglion; Trigeminal Nuclei	2009
Opioidergic and GABAergic mechanisms in the rostral ventromedial medulla modulate the nociceptive response of vocalization in guinea pigs. Brain research bulletin, 2010, May-31, Volume: 82, Issue:3-4 Topics: Analgesics, Opioid; Animals; Bicuculline; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Male; Medulla Oblongata; Morphine; Muscimol; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Vocalization, Animal	2010
Opioid receptor internalization contributes to dermorphin-mediated antinociception. Neuroscience, 2010, Jun-30, Volume: 168, Issue:2 Topics: Analgesics, Opioid; Animals; Bicuculline; Concanavalin A; Dynamins; Fluorescent Dyes; GABA-A Receptor Antagonists; Male; Microinjections; Naltrexone; Neurons; Opioid Peptides; Pain; Pain Measurement; Peptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu	2010
Analgesia induced by 2- or 100-Hz electroacupuncture in the rat tail-flick test depends on the activation of different descending pain inhibitory mechanisms. The journal of pain, 2011, Volume: 12, Issue:1 Topics: Adjuvants, Anesthesia; Adrenergic alpha-Antagonists; Analgesia; Anesthetics, Intravenous; Animals; Atropine; Baclofen; Bicuculline; Biophysics; Dioxanes; Disease Models, Animal; Electroacupuncture; GABA Agents; Male; Methysergide; Models, Biological; Multivariate Analysis; Naloxone; Narcotic Antagonists; Pain; Pain Management; Pain Measurement; Rats; Rats, Wistar; Reaction Time; Serotonin Antagonists; Tail; Thiopental; Time Factors	2011
The effect of intra-locus coeruleus injection of 17beta-estradiol on inflammatory pain modulation in male rat. Behavioural brain research, 2010, Dec-25, Volume: 214, Issue:2 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Disease Models, Animal; Estradiol; Estrogen Antagonists; Estrogens; Formaldehyde; Fulvestrant; Inflammation; Locus Coeruleus; Male; Microinjections; Pain; Rats; Rats, Sprague-Dawley; Valine	2010
T-type channels control the opioidergic descending analgesia at the low threshold-spiking GABAergic neurons in the periaqueductal gray. Proceedings of the National Academy of Sciences of the United States of America, 2010, Aug-17, Volume: 107, Issue:33 Topics: Analgesics, Opioid; Animals; Bicuculline; Calcium Channels, T-Type; Female; GABA Antagonists; GABA-A Receptor Antagonists; Green Fluorescent Proteins; In Situ Hybridization, Fluorescence; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Mice, Transgenic; Microscopy, Confocal; Neurons; Pain; Pain Measurement; Periaqueductal Gray; Receptors, GABA-A; RNA Interference	2010
Intracisternal or intrathecal glycine, taurine, or muscimol inhibit bicuculline-induced allodynia and thermal hyperalgesia in mice. Acta pharmacologica Sinica, 2010, Volume: 31, Issue:8 Topics: Animals; Bicuculline; Disease Models, Animal; Glycine; Hot Temperature; Hyperalgesia; Injections; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Muscimol; Pain; Pain Threshold; Receptors, GABA; Receptors, Glycine; Taurine	2010
Enhanced excitatory and reduced inhibitory synaptic transmission contribute to persistent pain-induced neuronal hyper-responsiveness in anterior cingulate cortex. Neuroscience, 2010, Dec-29, Volume: 171, Issue:4 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Analysis of Variance; Animals; Bee Venoms; Bicuculline; Biophysics; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Antagonists; GABA-A Receptor Antagonists; Gyrus Cinguli; Male; Neural Inhibition; Neurons; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Synaptic Transmission; Tetrodotoxin	2010
Spike-train communities: finding groups of similar spike trains. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Feb-09, Volume: 31, Issue:6 Topics: Action Potentials; Algorithms; Animals; Bicuculline; Cats; Cluster Analysis; Corpus Striatum; Electronic Data Processing; GABA-A Receptor Antagonists; Models, Neurological; Nerve Net; Neurons; Nonlinear Dynamics; Pain; Time Factors	2011
Differential effects of mGluR7 and mGluR8 activation on pain-related synaptic activity in the amygdala. Neuropharmacology, 2011, Volume: 61, Issue:8 Topics: Adjuvants, Immunologic; Amygdala; Animals; Arthritis; Benzhydryl Compounds; Bicuculline; Biophysics; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agents; Excitatory Postsynaptic Potentials; GABA Antagonists; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Neurons; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Synaptic Potentials	2011
Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors. Journal of neurophysiology, 2011, Volume: 106, Issue:5 Topics: Action Potentials; Animals; Arthritis, Experimental; Benzoates; Bicuculline; Disease Models, Animal; Electrophysiology; Excitatory Amino Acid Antagonists; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Male; Methoxyhydroxyphenylglycol; Neurons; Pain; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, GABA-A; Receptors, Metabotropic Glutamate	2011
In vivo patch-clamp recording from locus coeruleus neurones in the rat brainstem. The Journal of physiology, 2012, May-15, Volume: 590, Issue:10 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Inhibitory Postsynaptic Potentials; Locus Coeruleus; Male; Neurons; Pain; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA	2012
Inhibitory control of nociceptive responses of trigeminal spinal nucleus cells by somatosensory corticofugal projection in rat. Neuroscience, 2012, Sep-27, Volume: 221 Topics: Action Potentials; Afferent Pathways; Animals; Bicuculline; Biophysics; Capsaicin; Constriction; Disease Models, Animal; Electric Stimulation; Female; GABA-A Receptor Antagonists; Glutamic Acid; Glycine Agents; Hyperalgesia; Iontophoresis; Male; Neural Inhibition; Neuralgia; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Strychnine; Time Factors; Trigeminal Nucleus, Spinal	2012
Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat. Neuropharmacology, 2013, Volume: 66 Topics: Action Potentials; Amygdala; Animals; Bicuculline; Carrageenan; Chromones; Disease Models, Animal; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formaldehyde; GABA Antagonists; Gene Expression; Glycine; Male; Neural Inhibition; Neural Pathways; Neuronal Plasticity; Pain; Physical Stimulation; Prefrontal Cortex; Pyramidal Cells; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols	2013
Cerebellar stimulation modulates the intensity of a visceral nociceptive reflex in the rat. Experimental brain research, 2002, Volume: 146, Issue:1 Topics: Animals; Bicuculline; Brain Mapping; Cerebellar Cortex; Cerebellum; Colon; Electric Stimulation; Electromyography; GABA Agonists; Homocysteine; Male; Muscle, Skeletal; Neural Pathways; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Rectum; Reflex; Stereotaxic Techniques	2002
Somatic nociception activates NK1 receptors in the nucleus tractus solitarii to attenuate the baroreceptor cardiac reflex. The European journal of neuroscience, 2002, Volume: 16, Issue:5 Topics: Animals; Baroreflex; Bicuculline; Electrophysiology; GABA Antagonists; gamma-Aminobutyric Acid; Microinjections; Neural Inhibition; Neurokinin-1 Receptor Antagonists; Nociceptors; Pain; Pain Measurement; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Neurokinin-1; Solitary Nucleus; Substance P	2002
Trigeminal antinociception induced by bicuculline in the periaqueductal gray (PAG) is not affected by PAG P/Q-type calcium channel blockade in rat. Neuroscience letters, 2003, Jan-16, Volume: 336, Issue:2 Topics: Animals; Bicuculline; Calcium Channel Blockers; Calcium Channels, P-Type; Calcium Channels, Q-Type; Dose-Response Relationship, Drug; Electrophysiology; Male; Microinjections; Migraine Disorders; Neural Inhibition; Neurons; Nociceptors; omega-Agatoxin IVA; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Trigeminal Caudal Nucleus	2003
Bicuculline and strychnine suppress the mesencephalic locomotor region-induced inhibition of group III muscle afferent input to the dorsal horn. Neuroscience, 2003, Volume: 118, Issue:3 Topics: Afferent Pathways; Animals; Bicuculline; Cats; Efferent Pathways; Female; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Locomotion; Male; Muscle, Skeletal; Neural Inhibition; Pain; Posterior Horn Cells; Receptors, GABA-A; Receptors, Glycine; Reflex; Regional Blood Flow; Spinal Nerve Roots; Strychnine; Synaptic Transmission; Tegmentum Mesencephali; Vasoconstriction	2003
Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord. Pain, 2003, Volume: 106, Issue:1-2 Topics: Adrenergic alpha-Antagonists; Animals; Bicuculline; GABA Antagonists; Hyperalgesia; Joints; Male; Methysergide; Naloxone; Narcotic Antagonists; Pain; Pain Management; Physical Stimulation; Physical Therapy Modalities; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic; Receptors, GABA; Receptors, Opioid; Receptors, Serotonin; Serotonin Antagonists; Spinal Cord; Yohimbine	2003
Effects of corticotropin-releasing factor on plasticity of optically recorded neuronal activity in the substantia gelatinosa of rat spinal cord slices. Pain, 2003, Volume: 106, Issue:1-2 Topics: Animals; Bicuculline; Corticotropin-Releasing Hormone; GABA Antagonists; Glycine Agents; Long-Term Potentiation; Long-Term Synaptic Depression; Neuronal Plasticity; Neurons; Organ Culture Techniques; Pain; Rats; Rats, Sprague-Dawley; Strychnine; Substantia Gelatinosa	2003
Contribution of spinal inhibitory receptors in heterosegmental antinociception induced by noxious stimulation. The European journal of neuroscience, 2003, Volume: 18, Issue:11 Topics: Animals; Bicuculline; Capsaicin; Dose-Response Relationship, Drug; Drug Interactions; Electrodes, Implanted; Electromyography; GABA Antagonists; Glycine Agents; Male; Models, Neurological; Narcotic Antagonists; Neural Inhibition; Nucleus Accumbens; Organophosphorus Compounds; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Receptors, Opioid, mu; Spinal Cord; Strychnine	2003
Involvement of peripheral neuropeptide Y receptors in sympathetic modulation of acute cutaneous flare induced by intradermal capsaicin. Neuroscience, 2004, Volume: 123, Issue:2 Topics: Animals; Arginine; Benzazepines; Bicuculline; Capsaicin; Foot; GABA Antagonists; Inflammation; Injections, Spinal; Laser-Doppler Flowmetry; Male; Pain; Rats; Rats, Sprague-Dawley; Receptors, Neuropeptide Y; Skin; Spinal Cord; Sympathectomy; Sympathetic Nervous System	2004
Mechanical allodynia following contusion injury of the rat spinal cord is associated with loss of GABAergic inhibition in the dorsal horn. Pain, 2004, Volume: 109, Issue:3 Topics: Action Potentials; Animals; Bicuculline; Disease Models, Animal; Electric Stimulation; Female; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Hyperalgesia; Neural Inhibition; Neural Pathways; Pain; Physical Stimulation; Posterior Horn Cells; Rats; Rats, Wistar; Reaction Time; Receptors, GABA-A; Spinal Cord Injuries; Touch; Wounds, Nonpenetrating	2004
Corticothalamic modulation on formalin-induced change of VPM thalamic activities. Neuroreport, 2004, Jun-28, Volume: 15, Issue:9 Topics: Animals; Bicuculline; Formaldehyde; GABA Agonists; GABA Antagonists; Male; Muscimol; Neural Pathways; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Somatosensory Cortex; Ventral Thalamic Nuclei; Vibrissae	2004
Peripherally delivered glutamic acid decarboxylase gene therapy for spinal cord injury pain. Molecular therapy : the journal of the American Society of Gene Therapy, 2004, Volume: 10, Issue:1 Topics: Animals; Baclofen; Bicuculline; Calcitonin Gene-Related Peptide; gamma-Aminobutyric Acid; Ganglia, Spinal; Genetic Therapy; Genetic Vectors; Glutamate Decarboxylase; Hyperalgesia; Injections, Subcutaneous; Isoenzymes; Neurons; Pain; Rats; Simplexvirus; Spinal Cord Injuries; Tissue Distribution; Transduction, Genetic	2004
Activation of 5-HT(1B/1D) receptor in the periaqueductal gray inhibits nociception. Annals of neurology, 2004, Volume: 56, Issue:3 Topics: Animals; Bicuculline; Electric Stimulation; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Neural Inhibition; Pain; Pain Measurement; Periaqueductal Gray; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D	2004
GABAA receptor partially mediated propofol-induced hyperalgesia at superspinal level and analgesia at spinal cord level in rats. Acta pharmacologica Sinica, 2004, Volume: 25, Issue:12 Topics: Analgesia; Animals; Bicuculline; GABA Antagonists; GABA-A Receptor Antagonists; Hyperalgesia; Hypnotics and Sedatives; Male; Microinjections; Pain; Pain Measurement; Periaqueductal Gray; Propofol; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord	2004
Analgesic and anticonvulsant properties of Tetrapleura tetraptera (Taub) (Fabaceae) fruit aqueous extract in mice. Phytotherapy research : PTR, 2005, Volume: 19, Issue:12 Topics: Acetic Acid; Analgesics; Animals; Anticonvulsants; Bicuculline; Female; Fruit; Hot Temperature; Male; Mice; Mice, Inbred BALB C; Pain; Pentylenetetrazole; Phytotherapy; Picrotoxin; Plant Extracts; Seizures; Tetrapleura	2005
Contribution of the ventromedial hypothalamus to generation of the affective dimension of pain. Pain, 2006, Volume: 123, Issue:1-2 Topics: Affect; Animals; Bicuculline; Conditioning, Classical; Electric Stimulation; Electroshock; Fear; GABA Agonists; GABA Antagonists; Hindlimb; Hypothalamus; Male; Muscimol; Pain; Rats; Rats, Long-Evans; Receptors, GABA-A; Reflex; Spinal Cord; Tail; Ventromedial Hypothalamic Nucleus; Vocalization, Animal	2006
GABAA-Receptor blockade reverses the injury-induced sensitization of nociceptor-specific (NS) neurons in the spinal dorsal horn of the rat. Journal of neurophysiology, 2006, Volume: 96, Issue:2 Topics: Action Potentials; Animals; Bicuculline; Capsaicin; Electrophysiology; Female; GABA Antagonists; GABA-A Receptor Antagonists; Male; Mustard Plant; Neurons; Nociceptors; Pain; Physical Stimulation; Picrotoxin; Plant Oils; Posterior Horn Cells; Rats; Rats, Wistar; Stimulation, Chemical	2006
Interactions between opioid-peptides-containing pathways and GABA(A)-receptors-mediated systems modulate panic-like-induced behaviors elicited by electric and chemical stimulation of the inferior colliculus. Brain research, 2006, Aug-09, Volume: 1104, Issue:1 Topics: Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Drug Interactions; Electric Stimulation; Freezing Reaction, Cataleptic; GABA Antagonists; Inferior Colliculi; Male; Morphine; Naloxone; Narcotic Antagonists; Neural Pathways; Opioid Peptides; Pain; Rats; Rats, Wistar; Receptors, GABA-A; Stimulation, Chemical	2006
On the mechanism of carbamazepine-induced antinociception in the formalin test. The International journal of neuroscience, 2006, Volume: 116, Issue:9 Topics: Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Animal; Bicuculline; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Formaldehyde; GABA Antagonists; Male; Mice; Organophosphorus Compounds; Pain; Pain Measurement; Prazosin; Yohimbine	2006
Corticofugal output from the primary somatosensory cortex selectively modulates innocuous and noxious inputs in the rat spinothalamic system. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Aug-16, Volume: 26, Issue:33 Topics: Animals; Bicuculline; GABA Agonists; GABA Antagonists; GABA-A Receptor Antagonists; Hindlimb; Homocysteine; Hot Temperature; Male; Microinjections; Muscimol; Neural Pathways; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Somatosensory Cortex; Spinothalamic Tracts; Thalamic Nuclei	2006
[Effect of morphine on dorsal horn projection neurons in neuropathic pain rats]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2006, Volume: 31, Issue:4 Topics: Analgesics, Opioid; Animals; Bicuculline; Electrophysiology; Hyperesthesia; Male; Morphine; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spinal Nerves	2006
GABAA but not GABAB receptors in the rostral anterior cingulate cortex selectively modulate pain-induced escape/avoidance behavior. Experimental neurology, 2007, Volume: 204, Issue:1 Topics: Animals; Avoidance Learning; Baclofen; Bicuculline; Escape Reaction; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Gyrus Cinguli; Male; Microinjections; Muscimol; Pain; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B	2007
Involvement of GABA A receptor-associated chloride channels in the peripheral antinociceptive effect induced by GABA A receptor agonist muscimol. European journal of pharmacology, 2007, Jun-14, Volume: 564, Issue:1-3 Topics: Analysis of Variance; Animals; Bicuculline; Chloride Channels; Dinoprostone; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; Injections, Subcutaneous; Male; Muscimol; Pain; Pain Measurement; Picrotoxin; Potassium Channel Blockers; Potassium Channels; Pressure; Rats; Rats, Wistar; Receptors, GABA-A	2007
In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on the modulation of pain in mice. Brain, behavior, and immunity, 2008, Volume: 22, Issue:6 Topics: Analgesics; Animals; Benzamides; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Humans; Injections, Intraventricular; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Neurokinin-1 Receptor Antagonists; Pain; Pain Measurement; Peptide Fragments; Piperidines; Receptors, Neurokinin-2; Tachykinins; Tropanes	2008
GABAergic mechanisms in antinociception. Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:4-6 Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Analgesics; Animals; Baclofen; Bicuculline; Central Nervous System; gamma-Aminobutyric Acid; Isoxazoles; Mice; Muscimol; Pain; Rats; Stereoisomerism; Substance P; Synaptic Transmission; Vigabatrin	1984
[Pharmaco-ethological study of analgesia induced by intraspecies fighting behavior]. Biulleten' eksperimental'noi biologii i meditsiny, 1984, Volume: 98, Issue:12 Topics: Aggression; Analgesia; Animals; Behavior, Animal; Bicuculline; Conflict, Psychological; Dominance-Subordination; Humans; Male; Mice; Mice, Inbred C57BL; Naloxone; Pain; Sensory Thresholds; Time Factors	1984
Role of GABAergic systems in the development of morphine tolerance in formalin-treated mice. Japanese journal of pharmacology, 1995, Volume: 68, Issue:2 Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; GABA Agonists; GABA Antagonists; Male; Mice; Mice, Inbred Strains; Morphine; Muscimol; Pain; Pain Measurement; Receptors, GABA	1995
Allodynia evoked by intrathecal administration of prostaglandin E2 to conscious mice. Pain, 1994, Volume: 57, Issue:2 Topics: Animals; Bicuculline; Dinoprostone; Excitatory Amino Acid Antagonists; Glutamates; Glutamic Acid; Hyperalgesia; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Pain; Prostaglandin D2; Strychnine	1994
Glycine and GABAA antagonists reduce the inhibition of primate spinothalamic tract neurons produced by stimulation in periaqueductal gray. Brain research, 1994, Aug-22, Volume: 654, Issue:2 Topics: Animals; Bicuculline; Brain Mapping; Dose-Response Relationship, Drug; Electric Stimulation; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Glycine; Hot Temperature; Macaca fascicularis; Male; Muscimol; Neurons; Pain; Periaqueductal Gray; Physical Stimulation; Spinal Cord; Strychnine; Thalamus	1994
Interactions between laudanosine, GABA, and opioid subtype receptors: implication for laudanosine seizure activity. Brain research, 1994, May-23, Volume: 646, Issue:2 Topics: Animals; Bicuculline; Binding, Competitive; Brain; Cell Membrane; Cerebral Ventricles; GABA Antagonists; gamma-Aminobutyric Acid; Injections, Intraventricular; Injections, Spinal; Isoquinolines; Kinetics; Male; Mice; Mice, Inbred Strains; Muscimol; Narcotic Antagonists; Pain; Rats; Rats, Sprague-Dawley; Receptors, GABA; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Seizures; Spinal Cord; Substance Withdrawal Syndrome	1994
Area tempestas modulates the behavioural responses to nociceptive stimuli in rats. Annali dell'Istituto superiore di sanita, 1993, Volume: 29, Issue:3 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Anticonvulsants; Azocines; Bicuculline; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Leucine-2-Alanine; Enkephalins; Escape Reaction; Foot; Hot Temperature; Male; Morphine; Naltrexone; Narcotic Antagonists; Olfactory Pathways; Pain; Phenazocine; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Opioid; Seizures; Tail	1993
Effects of intrathecal strychnine and bicuculline on nerve compression-induced thermal hyperalgesia and selective antagonism by MK-801. Pain, 1993, Volume: 54, Issue:1 Topics: Animals; Bicuculline; Dizocilpine Maleate; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Hot Temperature; Injections, Spinal; Male; N-Methylaspartate; Nerve Crush; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Strychnine	1993
Basal release of Met-enkephalin and neurotensin in the ventrolateral periaqueductal gray matter of the rat: a microdialysis study of antinociceptive circuits. Brain research, 1995, Sep-04, Volume: 690, Issue:2 Topics: Animals; Basal Metabolism; Bicuculline; Enkephalin, Methionine; Feedback; GABA Antagonists; Male; Microdialysis; Morphine; Neural Pathways; Neurotensin; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley	1995
Involvement of glutamate receptors in strychnine- and bicuculline-induced allodynia in conscious mice. Anesthesiology, 1996, Volume: 84, Issue:5 Topics: Animals; Bicuculline; GABA Antagonists; Glycine Agents; Male; Mice; Nitric Oxide; Pain; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Strychnine	1996
Thiopentone induced enhancement of somatic motor responses to noxious stimulation: influence of GABAA receptor modulation. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:5 Pt 1 Topics: Animals; Bicuculline; GABA Modulators; Hypnotics and Sedatives; Male; Muscimol; Pain; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Thiopental	1996
[Concurrent characterization of spinal amino acid release and touch-evoked allodynia produced by spinal glycine or GABAA receptor antagonists]. Masui. The Japanese journal of anesthesiology, 1996, Volume: 45, Issue:4 Topics: Amino Acids; Animals; Bicuculline; GABA Antagonists; Glycine Agents; Injections, Spinal; Male; N-Methylaspartate; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Strychnine; Touch	1996
Endogenous opioid-mediated inhibition of putative pain-modulating neurons in rat rostral ventromedial medulla. Neuroscience, 1996, Volume: 74, Issue:3 Topics: Animals; Bicuculline; Brain Mapping; Enkephalins; Evoked Potentials; Male; Medulla Oblongata; Morphine; Naloxone; Nerve Endings; Neurons; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Reflex	1996
Endogenous opioids acting at a medullary mu-opioid receptor contribute to the behavioral antinociception produced by GABA antagonism in the midbrain periaqueductal gray. Neuroscience, 1996, Volume: 74, Issue:3 Topics: Animals; Bicuculline; Brain Mapping; GABA Antagonists; Male; Medulla Oblongata; Mesencephalon; Microinjections; Models, Neurological; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Time Factors	1996
Nociceptin or antinociceptin: potent spinal antinociceptive effect of orphanin FQ/nociceptin in the rat. Neuroreport, 1996, Sep-02, Volume: 7, Issue:13 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-2 Receptor Antagonists; Analysis of Variance; Animals; Bicuculline; Electromyography; Electroshock; Female; GABA-A Receptor Antagonists; Imidazoles; Injections, Spinal; Muscle, Skeletal; Naloxone; Narcotic Antagonists; Nerve Fibers; Nociceptin; Opioid Peptides; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Spinal Cord; Sural Nerve	1996
Role of spinal gamma-aminobutyric acidA receptors in formalin-induced nociception in the rat. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2 Topics: Animals; Bicuculline; Formaldehyde; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Injections, Spinal; Isonicotinic Acids; Male; Pain; Premedication; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Spinal Cord	1997
Involvement of supraspinal GABA-ergic systems in clonidine-induced antinociception in the tail-pinch test in mice. Life sciences, 1997, Volume: 61, Issue:11 Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Animals; Baclofen; Bicuculline; Clonidine; GABA Antagonists; gamma-Aminobutyric Acid; Male; Mice; Muscimol; Pain; Picrotoxin; Receptors, GABA; Tail	1997
Endogenous opioid peptides acting at mu-opioid receptors in the dorsal horn contribute to midbrain modulation of spinal nociceptive neurons. Journal of neurophysiology, 1998, Volume: 79, Issue:2 Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Bicuculline; Clonidine; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Excitatory Amino Acid Agonists; GABA Antagonists; Hot Temperature; Iontophoresis; Kainic Acid; Male; Medulla Oblongata; N-Methylaspartate; Naloxone; Narcotic Antagonists; Nociceptors; Opioid Peptides; Pain; Peptide Fragments; Peptides; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Opioid, mu; Somatostatin; Spinal Cord; Tail	1998
Spinal effects of bicuculline: modulation of an allodynia-like state by an A1-receptor agonist, morphine, and an NMDA-receptor antagonist. Journal of neurophysiology, 1998, Volume: 79, Issue:3 Topics: Adenosine; Animals; Bicuculline; Dose-Response Relationship, Drug; GABA Antagonists; Kynurenic Acid; Male; Morphine; Naloxone; Nerve Fibers; Neurons; Pain; Physical Stimulation; Purinergic P1 Receptor Agonists; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Touch	1998
[Preemptive analgesia]. Masui. The Japanese journal of anesthesiology, 1997, Volume: 46 Suppl Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Formaldehyde; GABA Antagonists; gamma-Aminobutyric Acid; Glycine; Glycine Agents; Neurotransmitter Agents; Pain; Pain Measurement; Rats; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Strychnine	1997
GABAA receptor blockade inhibits A beta fibre evoked wind-up in the arthritic rat. Neuroreport, 1998, Apr-20, Volume: 9, Issue:6 Topics: Animals; Arthritis; Bicuculline; Decerebrate State; Dose-Response Relationship, Drug; Electromyography; Female; GABA Antagonists; GABA-A Receptor Antagonists; Hindlimb; Knee Joint; Male; Nerve Fibers, Myelinated; Pain; Rats; Rats, Wistar; Touch	1998
Midbrain periaqueductal gray (PAG) inhibits nociceptive inputs to sacral dorsal horn nociceptive neurons through alpha2-adrenergic receptors. Journal of neurophysiology, 1998, Volume: 80, Issue:5 Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Bicuculline; Clonidine; Excitatory Amino Acids; Hot Temperature; Idazoxan; Iontophoresis; Male; Methoxamine; Neural Inhibition; Neurons; Norepinephrine; Pain; Periaqueductal Gray; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Spinal Cord; Synapses	1998
Lack of tactile pain (allodynia) in lipocalin-type prostaglandin D synthase-deficient mice. Proceedings of the National Academy of Sciences of the United States of America, 1999, Jan-19, Volume: 96, Issue:2 Topics: Anesthesia; Animals; Bicuculline; Central Nervous System; Dinoprost; Dinoprostone; GABA Antagonists; Gene Targeting; Hydantoins; Hyperalgesia; Immunohistochemistry; Intramolecular Oxidoreductases; Lipocalins; Mice; Mice, Knockout; Molecular Sequence Data; Pain; Prostaglandin D2; Receptors, Prostaglandin	1999
Effects of GABA receptor antagonist on trigeminal caudalis nociceptive neurons in normal and neonatally capsaicin-treated rats. Journal of neurophysiology, 1999, Volume: 82, Issue:5 Topics: Animals; Animals, Newborn; Baclofen; Bicuculline; Brain Mapping; Capsaicin; Functional Laterality; GABA Antagonists; GABA-A Receptor Antagonists; Male; Medulla Oblongata; Microinjections; Neuronal Plasticity; Neurons; Nociceptors; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Touch; Trigeminal Nerve	1999
Robust changes of afferent-induced excitation in the rat spinal dorsal horn after conditioning high-frequency stimulation. Journal of neurophysiology, 2000, Volume: 83, Issue:4 Topics: 2-Amino-5-phosphonovalerate; Animals; Bicuculline; Chlorides; Conditioning, Psychological; Electric Stimulation; Electrophysiology; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; GABA Antagonists; Glycine Agents; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Naloxone; Narcotic Antagonists; Neuronal Plasticity; Optics and Photonics; Pain; Posterior Horn Cells; Potassium; Rats; Rats, Sprague-Dawley; Spinal Nerve Roots; Strychnine	2000
Electrophysiologic evidence for increased endogenous gabaergic but not glycinergic inhibitory tone in the rat spinal nerve ligation model of neuropathy. Anesthesiology, 2001, Volume: 94, Issue:2 Topics: Animals; Bicuculline; Cold Temperature; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Glycine; Male; Nerve Fibers, Myelinated; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Strychnine	2001
Coadministration of intrathecal strychnine and bicuculline effects synergistic allodynia in the rat: an isobolographic analysis. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:3 Topics: Analysis of Variance; Animals; Bicuculline; Convulsants; Drug Synergism; Injections, Spinal; Male; Pain; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Strychnine	2001
GABA mechanisms and antinociception in mice with ligated sciatic nerve. Pharmacology & toxicology, 2001, Volume: 89, Issue:2 Topics: Animals; Baclofen; Bicuculline; Dose-Response Relationship, Drug; Drug Interactions; GABA Agonists; GABA Antagonists; Ligation; Male; Mice; Mice, Inbred Strains; Morphine; Muscimol; Naloxone; Organophosphorus Compounds; Pain; Pain Measurement; Sciatic Nerve	2001
Role of benzodiazepine-GABAA receptor complex in attenuation of U-50,488H-induced analgesia and inhibition of tolerance to its analgesia by ginseng total saponin in mice. Life sciences, 2002, Mar-01, Volume: 70, Issue:15 Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics, Non-Narcotic; Animals; Bicuculline; Diazepam; Dose-Response Relationship, Drug; Drug Antagonism; Drug Tolerance; Drugs, Chinese Herbal; Flumazenil; Ginsenosides; Injections, Intraperitoneal; Male; Mice; Pain; Pain Threshold; Panax; Picrotoxin; Receptors, GABA-A; Receptors, Opioid, kappa; Saponins; Tail	2002
Peripheral vibration causes an adenosine-mediated postsynaptic inhibitory potential in dorsal horn neurons of the cat spinal cord. Neuroscience, 1992, Volume: 50, Issue:2 Topics: Adenosine; Adenosine Monophosphate; Animals; Bicuculline; Cats; Evoked Potentials; Iontophoresis; Membrane Potentials; Naloxone; Neurons; Pain; Physical Stimulation; Purinergic Antagonists; Spinal Cord; Strychnine; Synapses; Theophylline; Vibration	1992
Analgesic profile of centrally administered 2-methylserotonin against acute pain in rats. European journal of pharmacology, 1991, Jun-25, Volume: 199, Issue:2 Topics: Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Spinal; Ketanserin; Male; Mianserin; Motor Activity; Naloxone; Nociceptors; Pain; Rats; Rats, Inbred Strains; Receptors, Serotonin; Respiration; Serotonin; Serotonin Antagonists; Tropanes	1991
On the mechanism by which midazolam causes spinally mediated analgesia. Anesthesiology, 1990, Volume: 73, Issue:2 Topics: Analgesia, Epidural; Animals; Bicuculline; Cyclazocine; Dose-Response Relationship, Drug; Electric Stimulation; Ethylketocyclazocine; Fentanyl; Flumazenil; Male; Midazolam; Pain; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sensory Thresholds	1990
Dual action of substance P in nociception and pain modulation at spinal level. Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences, 1987, Volume: 30, Issue:7 Topics: Animals; Bicuculline; Efferent Pathways; Naloxone; Neurons; Nociceptors; Pain; Rats; Spinal Cord; Substance P	1987
GABAergic agents-induced antinociceptive effect in mice. Methods and findings in experimental and clinical pharmacology, 1989, Volume: 11, Issue:10 Topics: Analgesics; Animals; Baclofen; Bicuculline; Female; gamma-Aminobutyric Acid; Male; Mice; Morphine; Muscimol; Pain; Picrotoxin; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds; Valproic Acid	1989
[Effect of electroacupuncture on nociceptive responses after topical application of bicuculline in the rat]. Zhen ci yan jiu = Acupuncture research, 1989, Volume: 14, Issue:3 Topics: Acupuncture Analgesia; Animals; Bicuculline; Efferent Pathways; Electroacupuncture; Male; Nociceptors; Pain; Rats; Sensory Thresholds; Somatosensory Cortex	1989
Behavioral and autonomic correlates of the tactile evoked allodynia produced by spinal glycine inhibition: effects of modulatory receptor systems and excitatory amino acid antagonists. Pain, 1989, Volume: 37, Issue:1 Topics: Analgesics; Animals; Autonomic Nervous System Diseases; Bicuculline; Blood Pressure; Dose-Response Relationship, Drug; Male; Pain; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Spinal Cord; Strychnine	1989
Effects of bicuculline on the changes of pain threshold and some neurotransmitters of brain in rats induced by EAA. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 1988, Volume: 8, Issue:2 Topics: Acupuncture Therapy; Animals; Bicuculline; Brain; Electric Stimulation; Female; Male; Medulla Oblongata; Neurotransmitter Agents; Pain; Pons; Rats; Receptors, GABA-A; Sensory Thresholds	1988
Nociceptive responses to altered GABAergic activity at the spinal cord. Life sciences, 1986, Nov-03, Volume: 39, Issue:18 Topics: Animals; Bicuculline; Female; gamma-Aminobutyric Acid; Injections, Spinal; Motor Activity; Muscimol; Pain; Pain Measurement; Physical Stimulation; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sensory Thresholds; Tail; Vocalization, Animal	1986
Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists. Naunyn-Schmiedeberg's archives of pharmacology, 1986, Volume: 333, Issue:1 Topics: Animals; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Flumazenil; Injections, Intraventricular; Male; Morphine; Pain; Rats; Rats, Inbred Strains	1986
[Effects of intraperitoneal injection of bicuculline or atropine on electro-acupuncture analgesic effect and the changes in the brain noradrenaline content in rats]. Zhen ci yan jiu = Acupuncture research, 1988, Volume: 13, Issue:4 Topics: Acupuncture Therapy; Animals; Atropine; Bicuculline; Brain; Electric Stimulation Therapy; Injections, Intraperitoneal; Male; Norepinephrine; Pain; Rats; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation	1988
GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat. Brain research, 1988, May-31, Volume: 450, Issue:1-2 Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Oxazoles; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds	1988
[Potentiation of acupuncture analgesia by GABA in the dorsal raphe nucleus]. Sheng li xue bao : [Acta physiologica Sinica], 1986, Volume: 38, Issue:2 Topics: 3-Mercaptopropionic Acid; Acupuncture Therapy; Animals; Bicuculline; Electric Stimulation Therapy; gamma-Aminobutyric Acid; Male; Muscimol; Nipecotic Acids; Pain; Raphe Nuclei; Rats; Sensory Thresholds; Transcutaneous Electric Nerve Stimulation	1986
Evidence for GABA involvement in midbrain control of medullary neurons that modulate nociceptive transmission. Brain research, 1986, Nov-05, Volume: 397, Issue:1 Topics: Action Potentials; Animals; Bicuculline; gamma-Aminobutyric Acid; Male; Medulla Oblongata; Morphine; Muscimol; Neural Pathways; Pain; Pain Measurement; Periaqueductal Gray; Picrotoxin; Rats; Rats, Inbred Strains	1986