flumazenil has been researched along with Pain in 33 studies
Flumazenil: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.
flumazenil : An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intra- and postoperative wake-up tests were performed together with somatosensory cortical evoked potentials (SCEPs) monitoring in 40 patients randomized to either midazolam (M) or propofol (P) infusions for scoliosis surgery." | 9.08 | Midazolam-flumazenil versus propofol anaesthesia for scoliosis surgery with wake-up tests. ( Hesselbjerg, L; Koscielniak-Nielsen, ZJ; Stens-Pedersen, HL, 1998) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 7.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "midazolam were significantly reversed by i." | 5.31 | Effects of midazolam in the spinal nerve ligation model of neuropathic pain in rats. ( Dickenson, AH; Kontinen, VK, 2000) |
| "Intra- and postoperative wake-up tests were performed together with somatosensory cortical evoked potentials (SCEPs) monitoring in 40 patients randomized to either midazolam (M) or propofol (P) infusions for scoliosis surgery." | 5.08 | Midazolam-flumazenil versus propofol anaesthesia for scoliosis surgery with wake-up tests. ( Hesselbjerg, L; Koscielniak-Nielsen, ZJ; Stens-Pedersen, HL, 1998) |
| "We determined if cutaneous hyperalgesia and pain-induced c-Fos overexpression in the spinal cord produced by repeated forced swimming (FS) stress in the rat were related to changes in GABA neurotransmission by studying spinal release of GABA and the effect of positive modulation of GABA-A receptors with diazepam." | 3.74 | Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress. ( Leal, L; Pinerua-Shuhaibar, L; Quintero, L; Silva, JA; Suarez-Roca, H, 2008) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 3.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "Repeated exposure to pain under the influence of the opiate antagonists naloxone and naltrexone leads to the recruitment of substantial analgesia as measured by paw-lick latency on the hot-plate test (4,11)." | 3.67 | Naloxone-induced analgesia: effects of the benzodiazepine antagonist Ro 15-1788. ( Cappell, H; Knoke, DM; Lê, AD; Poulos, CX, 1989) |
| "Remimazolam tosilate (RT) is a novel short-acting GABA (A) receptor agonist that has a rapid recovery from procedural sedation and can be fully reversed by flumazenil." | 3.30 | Efficacy and safety of remimazolam tosilate versus propofol in patients undergoing day surgery: a prospective randomized controlled trial. ( Huang, J; Liu, M; Luo, W; Miao, C; Sun, M; Wan, J; Xia, L; Xiong, W; Xu, P; Zhang, J; Zhang, X; Zhang, Z; Zhong, J, 2023) |
| "Flumazenil was administered after the completion of endoscopy under sedation to reduce recovery time and increase patient safety." | 2.79 | Delayed flumazenil injection after endoscopic sedation increases patient satisfaction compared with immediate flumazenil injection. ( Bang, BW; Chung, HJ; Jeong, S; Kim, HG; Kwon, KS; Lee, DH; Park, SG; Shin, YW, 2014) |
| "Diazepam and midazolam were equivalent as judged by sedation, recovery time, patient tolerance, and ease of examination." | 2.69 | Midazolam versus diazepam in lipid emulsion as conscious sedation for colonoscopy with or without reversal of sedation with flumazenil. ( Gevers, AM; Hendrickx, A; Macken, E; Rutgeerts, P, 1998) |
| "midazolam were significantly reversed by i." | 1.31 | Effects of midazolam in the spinal nerve ligation model of neuropathic pain in rats. ( Dickenson, AH; Kontinen, VK, 2000) |
| "This is a report of the results of 25 experiments in five rats investigating the dose-response relationship for the antinociceptive effects of chlordiazepoxide given intrathecally in the dose range 0." | 1.28 | Spinally mediated antinociception following intrathecal chlordiazepoxide--further evidence for a benzodiazepine spinal analgesic effect. ( Boulter, N; Gent, JP; Goodchild, CS; Serrao, JM, 1991) |
| " Flumazenil (Ro 15-1788) administration caused a parallel shift to the right of the dose-response curve for midazolam spinal analgesia." | 1.28 | On the mechanism by which midazolam causes spinally mediated analgesia. ( Edwards, M; Gent, JP; Goodchild, CS; Serrao, JM, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (36.36) | 18.7374 |
| 1990's | 12 (36.36) | 18.2507 |
| 2000's | 6 (18.18) | 29.6817 |
| 2010's | 2 (6.06) | 24.3611 |
| 2020's | 1 (3.03) | 2.80 |
| Authors | Studies |
|---|---|
| Luo, W | 1 |
| Sun, M | 1 |
| Wan, J | 1 |
| Zhang, Z | 1 |
| Huang, J | 1 |
| Zhang, J | 1 |
| Xiong, W | 1 |
| Xia, L | 1 |
| Xu, P | 1 |
| Miao, C | 1 |
| Zhang, X | 1 |
| Liu, M | 1 |
| Zhong, J | 1 |
| Chung, HJ | 1 |
| Bang, BW | 1 |
| Kim, HG | 1 |
| Kwon, KS | 1 |
| Shin, YW | 1 |
| Jeong, S | 1 |
| Lee, DH | 1 |
| Park, SG | 1 |
| Wolkers, CP | 1 |
| Barbosa Junior, A | 1 |
| Menescal-de-Oliveira, L | 1 |
| Hoffmann, A | 1 |
| Esterlis, I | 1 |
| Cosgrove, KP | 1 |
| Batis, JC | 1 |
| Bois, F | 1 |
| Kloczynski, TA | 1 |
| Stiklus, SM | 1 |
| Perry, E | 1 |
| Tamagnan, GD | 1 |
| Seibyl, JP | 1 |
| Makuch, R | 1 |
| Krishnan-Sarin, S | 1 |
| O'Malley, S | 1 |
| Staley, JK | 1 |
| Kumar, A | 1 |
| Kulkarni, SK | 1 |
| Suarez-Roca, H | 1 |
| Leal, L | 1 |
| Silva, JA | 1 |
| Pinerua-Shuhaibar, L | 1 |
| Quintero, L | 1 |
| Rahman, AF | 2 |
| Takahashi, M | 2 |
| Kaneto, H | 2 |
| Mainwaring, CJ | 1 |
| Wong, C | 1 |
| Lush, RJ | 1 |
| Smith, JG | 1 |
| Singer, CR | 1 |
| Todd, KH | 1 |
| Macken, E | 1 |
| Gevers, AM | 1 |
| Hendrickx, A | 1 |
| Rutgeerts, P | 1 |
| Koscielniak-Nielsen, ZJ | 1 |
| Stens-Pedersen, HL | 1 |
| Hesselbjerg, L | 1 |
| Larson, JS | 1 |
| Lunn, JJ | 1 |
| Kontinen, VK | 1 |
| Dickenson, AH | 1 |
| Rolland, A | 1 |
| Fleurentin, J | 1 |
| Lanhers, MC | 1 |
| Misslin, R | 1 |
| Mortier, F | 1 |
| Nemmani, KV | 1 |
| Ramarao, P | 1 |
| Serrao, JM | 3 |
| Goodchild, CS | 3 |
| Gent, JP | 3 |
| Boulter, N | 1 |
| Clavier, N | 1 |
| Lombard, MC | 1 |
| Besson, JM | 1 |
| Rovati, LC | 1 |
| Sacerdote, P | 1 |
| Fumagalli, P | 1 |
| Bianchi, M | 1 |
| Mantegazza, P | 3 |
| Panerai, AE | 1 |
| Edwards, M | 1 |
| Cappell, H | 1 |
| Knoke, DM | 1 |
| Lê, AD | 1 |
| Poulos, CX | 1 |
| Daghero, AM | 1 |
| Bradley, EL | 1 |
| Kissin, I | 1 |
| Kubota, K | 1 |
| Sugaya, K | 1 |
| Matsuda, I | 1 |
| Matsuoka, Y | 1 |
| Terawaki, Y | 1 |
| Palaoğlu, O | 1 |
| Ayhan, IH | 1 |
| Kavaliers, M | 2 |
| Hirst, M | 1 |
| Walsh, TJ | 1 |
| McLamb, RL | 1 |
| Tilson, HA | 1 |
| Zambotti, F | 2 |
| Zonta, N | 2 |
| Tammiso, R | 2 |
| Ferrario, P | 2 |
| Hafner, B | 2 |
| Rodgers, RJ | 1 |
| Randall, JI | 1 |
| Conci, F | 1 |
| Zecca, L | 1 |
| Davidovich, S | 1 |
| Niv, D | 1 |
| Geller, E | 1 |
| Urca, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparison of Three Different Pain and Anxiety Reducing Methods in Adult Patients Undergoing Bone Marrow Puncture[NCT00188227] | Phase 4 | 748 participants | Interventional | 2001-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for flumazenil and Pain
| Article | Year |
|---|---|
Comparing drugs for short-term sedation.
Topics: Anesthesia; Benzodiazepines; Conscious Sedation; Diazepam; Flumazenil; Humans; Lorazepam; Midazolam; | 1994 |
4 trials available for flumazenil and Pain
| Article | Year |
|---|---|
Efficacy and safety of remimazolam tosilate versus propofol in patients undergoing day surgery: a prospective randomized controlled trial.
Topics: Ambulatory Surgical Procedures; Flumazenil; Humans; Hypotension; Pain; Propofol; Prospective Studies | 2023 |
Delayed flumazenil injection after endoscopic sedation increases patient satisfaction compared with immediate flumazenil injection.
Topics: Adult; Anesthesia Recovery Period; Endoscopy; Female; Flumazenil; GABA Modulators; Humans; Male; Mem | 2014 |
Midazolam versus diazepam in lipid emulsion as conscious sedation for colonoscopy with or without reversal of sedation with flumazenil.
Topics: Adolescent; Adult; Analysis of Variance; Anesthetics, Combined; Anesthetics, Intravenous; Antidotes; | 1998 |
Midazolam-flumazenil versus propofol anaesthesia for scoliosis surgery with wake-up tests.
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; An | 1998 |
28 other studies available for flumazenil and Pain
| Article | Year |
|---|---|
GABAA-benzodiazepine receptors in the dorsomedial (Dm) telencephalon modulate restraint-induced antinociception in the fish Leporinus macrocephalus.
Topics: Analysis of Variance; Animals; Fishes; Flumazenil; Formaldehyde; GABA Modulators; Locomotion; Microi | 2015 |
GABAA-benzodiazepine receptor availability in smokers and nonsmokers: relationship to subsyndromal anxiety and depression.
Topics: Adult; Anxiety; Brain; Brain Mapping; Depression; Female; Flumazenil; Humans; Magnetic Resonance Ima | 2009 |
Protective effect of BR-16A, a polyherbal preparation against social isolation stress: possible GABAergic mechanism.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Drug Interactions; Female; Flumazenil; GABA Ago | 2006 |
Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress.
Topics: Analysis of Variance; Animals; Diazepam; Flumazenil; GABA Modulators; gamma-Aminobutyric Acid; Hyper | 2008 |
Role of GABAergic systems in the development of morphine tolerance in formalin-treated mice.
Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Diazepam; Drug Tolerance; Flumazenil; Formaldehy | 1995 |
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice.
Topics: Animals; Anxiety; Aspirin; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; Indomethacin; Inflamm | 1994 |
The role of midazolam-induced sedation in bone marrow aspiration/trephine biopsies.
Topics: Adolescent; Adult; Aged; Anesthetics, Local; Antidotes; Awareness; Bone Marrow; Conscious Sedation; | 1996 |
A significant difference is one that makes a difference.
Topics: Anesthetics, Intravenous; Antidotes; Benzodiazepines; Clinical Trials as Topic; Conscious Sedation; | 1997 |
Effects of midazolam in the spinal nerve ligation model of neuropathic pain in rats.
Topics: Animals; Cold Temperature; Electrophysiology; Evoked Potentials; Flumazenil; GABA Modulators; Inject | 2000 |
Neurophysiological effects of an extract of Eschscholzia californica Cham. (Papaveraceae).
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Anxiety Agents; Behavior, Animal; Dose-Response | 2001 |
Role of benzodiazepine-GABAA receptor complex in attenuation of U-50,488H-induced analgesia and inhibition of tolerance to its analgesia by ginseng total saponin in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2002 |
Reversal by naloxone of spinal antinociceptive effects of fentanyl, ketocyclazocine and midazolam.
Topics: Analgesia, Epidural; Animals; Catheters, Indwelling; Dose-Response Relationship, Drug; Drug Toleranc | 1991 |
Spinally mediated antinociception following intrathecal chlordiazepoxide--further evidence for a benzodiazepine spinal analgesic effect.
Topics: Analgesia, Epidural; Animals; Catheters, Indwelling; Chlordiazepoxide; Dose-Response Relationship, D | 1991 |
Benzodiazepines and pain: effects of midazolam on the activities of nociceptive non-specific dorsal horn neurons in the rat spinal cord.
Topics: Analysis of Variance; Animals; Electric Stimulation; Flumazenil; Male; Midazolam; Nerve Fibers; Neur | 1992 |
Benzodiazepines and their antagonists interfere with opioid-dependent stress-induced analgesia.
Topics: Analgesia; Animals; Benzodiazepines; Drug Interactions; Electroshock; Flumazenil; In Vitro Technique | 1990 |
On the mechanism by which midazolam causes spinally mediated analgesia.
Topics: Analgesia, Epidural; Animals; Bicuculline; Cyclazocine; Dose-Response Relationship, Drug; Electric S | 1990 |
Naloxone-induced analgesia: effects of the benzodiazepine antagonist Ro 15-1788.
Topics: Analgesia; Animals; Drug Interactions; Flumazenil; Male; Naloxone; Pain; Rats; Rats, Inbred Strains; | 1989 |
Midazolam antagonizes the analgesic effect of morphine in rats.
Topics: Animals; Flumazenil; Male; Midazolam; Morphine; Pain; Rats; Rats, Inbred Strains; Receptors, GABA-A; | 1987 |
Proceedings of the International Symposium on the Uses of Midazolam and Flumazenil in Intensive Care. Saint-Paul-de Vence, France, October 16, 1986.
Topics: Critical Care; Flumazenil; Humans; Midazolam; Pain | 1988 |
Reversal of antinociceptive effect of cholecystokinin by benzodiazepines and a benzodiazepine antagonist, Ro 15-1788.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Benzodiazepinones; Chlordiazepoxide; Cholecystokinin; Diaz | 1985 |
The possible role of benzodiazepine receptors in morphine analgesia.
Topics: Animals; Benzodiazepinones; Diazepam; Drug Interactions; Flumazenil; Male; Mice; Morphine; Pain; Rec | 1986 |
An octadecaneuropeptide (ODN) derived from diazepam binding inhibitor increases aggressive interactions in mice.
Topics: Aggression; Animals; Diazepam Binding Inhibitor; Flumazenil; Injections, Intraventricular; Male; Mic | 1986 |
A comparison of the effects of RO15,1788 and chlordiazepoxide on hot-plate latencies, acoustic startle, and locomotor activity.
Topics: Acoustic Stimulation; Animals; Benzodiazepinones; Chlordiazepoxide; Flumazenil; Male; Motor Activity | 1986 |
Reversal of the effect of centrally-administered diazepam on morphine antinociception by specific (Ro 15-1788 and Ro 15-3505) and non-specific (bicuculline and caffeine) benzodiazepine antagonists.
Topics: Animals; Benzodiazepinones; Bicuculline; Caffeine; Diazepam; Flumazenil; Injections, Intraventricula | 1986 |
Social conflict analgesia: inhibition of early non-opioid component by diazepam or flumazepil fails to affect appearance of late opioid component.
Topics: Aggression; Animals; Appetitive Behavior; Conflict, Psychological; Diazepam; Endorphins; Flumazenil; | 1987 |
Zopiclone potentiates the antinociceptive effect of morphine in rats.
Topics: Animals; Azabicyclo Compounds; Benzodiazepines; Benzodiazepinones; Drug Synergism; Flumazenil; Hypno | 1987 |
RO 15-1788 produces naloxone-reversible analgesia in the rat.
Topics: Analgesics; Animals; Flumazenil; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mi | 1988 |
Brief exposure to a natural predator, the short-tailed weasel, induces benzodiazepine-sensitive analgesia in white-footed mice.
Topics: Analgesia; Animals; Appetitive Behavior; Diazepam; Flumazenil; Handling, Psychological; Hot Temperat | 1988 |