Page last updated: 2024-08-01 19:55:11
ay 25,205
Description
alarelin: gonadotropin-releasing hormone analog widely used in China for the treatment of endometriosis and uterine leiomyoma [MeSH]
Cross-References
Synonyms (32)
| Synonym |
|---|
| alarelin acetate |
| 79561-22-1 |
| alarelin |
| A839717 |
| SCHEMBL11315269 |
| njs328sua7 , |
| dalareline |
| lhrh-a2 |
| dalarelin |
| L-4513 , |
| CHEMBL3272561 |
| gtpl9342 |
| AKOS030213241 |
| AKOS030260542 |
| NCGC00485985-01 |
| DTXSID40873497 |
| glp-his-trp-ser-tyr-d-ala-leu-arg-pro-nhet |
| AMY25366 |
| CCG-270649 |
| wy-18481 |
| tap-127 |
| alarelin [who-dd] |
| ay-25205 |
| CS-0015083 |
| HY-P0048 |
| tap 127 |
| surfagon |
| ay-25,205 |
| brn 0906592 |
| wy 18481 |
| (d-ala(sup 6)-des-gly-nh2(sup 10))lhrh ethylamide |
| unii-njs328sua7 |
Bioassays (8)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID1148725 | Induction of LH release in immature rat administered as infusion relative to LH-RH | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
ISSN: 0022-2623 | Inhibitors of the luteinizing hormone-releasing hormone based upon modifications in the 2, 3, and 6 positions. |
| AID1148726 | Induction of FSH release in immature rat administered as infusion relative to LH-RH | 1976 | Journal of medicinal chemistry, Feb, Volume: 19, Issue:2
ISSN: 0022-2623 | Inhibitors of the luteinizing hormone-releasing hormone based upon modifications in the 2, 3, and 6 positions. |
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
ISSN: 2472-5560 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5
ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346002 | Human GnRH1 receptor (Gonadotrophin-releasing hormone receptors) | 2016 | British journal of pharmacology, Jan, Volume: 173, Issue:1
ISSN: 1476-5381 | Characterization of 12 GnRH peptide agonists - a kinetic perspective. |
Research
Studies (156)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 115 (73.72) | 18.7374 |
| 1990's | 19 (12.18) | 18.2507 |
| 2000's | 10 (6.41) | 29.6817 |
| 2010's | 9 (5.77) | 24.3611 |
| 2020's | 3 (1.92) | 2.80 |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 5 (2.99%) | 6.00% |
| Case Studies | 2 (1.20%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 160 (95.81%) | 84.16% |
Characterization of 12 GnRH peptide agonists - a kinetic perspective.British journal of pharmacology, , Volume: 173, Issue:1, 2016
Inhibitors of the luteinizing hormone-releasing hormone based upon modifications in the 2, 3, and 6 positions.Journal of medicinal chemistry, , Volume: 19, Issue:2, 1976
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|
| pyrrolidonecarboxylic acid | | 5-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid | algal metabolite | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| diphenylamine | | aromatic amine;
bridged diphenyl fungicide;
secondary amino compound | antifungal agrochemical;
antioxidant;
carotogenesis inhibitor;
EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor;
ferroptosis inhibitor;
radical scavenger | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| buserelin | | oligopeptide | | 2017 | 2017 | 7.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| pd 0325901 | | difluorobenzene;
hydroxamic acid ester;
monofluorobenzenes;
organoiodine compound;
propane-1,2-diols;
secondary amino compound | antineoplastic agent;
EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor | 2020 | 2020 | 4.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| trelstar | | | | 2019 | 2019 | 5.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| cetrorelix | | oligopeptide | antineoplastic agent;
GnRH antagonist | 2012 | 2014 | 11.0 | low | 0 | 0 | 0 | 0 | 2 | 0 |
| gamma-aminobutyric acid | | amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid | human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| chlordecone | | cyclic ketone;
organochlorine compound | insecticide;
persistent organic pollutant | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| lactic acid | | 2-hydroxy monocarboxylic acid | algal metabolite;
Daphnia magna metabolite | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| inositol | | cyclitol;
hexol | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| valproic acid | | branched-chain fatty acid;
branched-chain saturated fatty acid | anticonvulsant;
antimanic drug;
EC 3.5.1.98 (histone deacetylase) inhibitor;
GABA agent;
neuroprotective agent;
psychotropic drug;
teratogenic agent | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| domperidone | | benzimidazoles;
heteroarylpiperidine | antiemetic;
dopaminergic antagonist | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| flutamide | | (trifluoromethyl)benzenes;
monocarboxylic acid amide | androgen antagonist;
antineoplastic agent | 2001 | 2001 | 23.0 | low | 0 | 0 | 0 | 1 | 0 | 0 |
| indomethacin | | aromatic ether;
indole-3-acetic acids;
monochlorobenzenes;
N-acylindole | analgesic;
drug metabolite;
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor;
environmental contaminant;
gout suppressant;
non-steroidal anti-inflammatory drug;
xenobiotic metabolite;
xenobiotic | 1982 | 1984 | 40.8 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| 1-methyl-3-isobutylxanthine | | 3-isobutyl-1-methylxanthine | | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| metoclopramide | | benzamides;
monochlorobenzenes;
substituted aniline;
tertiary amino compound | antiemetic;
dopaminergic antagonist;
environmental contaminant;
gastrointestinal drug;
xenobiotic | 1984 | 2011 | 26.5 | low | 0 | 1 | 0 | 0 | 1 | 0 |
| octopamine | | phenylethanolamines;
tyramines | neurotransmitter | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| proadifen | | diarylmethane | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| propranolol | | naphthalenes;
propanolamine;
secondary amine | anti-arrhythmia drug;
antihypertensive agent;
anxiolytic drug;
beta-adrenergic antagonist;
environmental contaminant;
human blood serum metabolite;
vasodilator agent;
xenobiotic | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| reserpine | | alkaloid ester;
methyl ester;
yohimban alkaloid | adrenergic uptake inhibitor;
antihypertensive agent;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
environmental contaminant;
first generation antipsychotic;
plant metabolite;
xenobiotic | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| phentolamine | | imidazoles;
phenols;
substituted aniline;
tertiary amino compound | alpha-adrenergic antagonist;
vasodilator agent | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| alloxan | | pyrimidone | hyperglycemic agent;
metabolite | 1980 | 1980 | 44.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| estrone | | 17-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols | antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite | 1983 | 1986 | 39.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| alanine | | alanine zwitterion;
alanine;
L-alpha-amino acid;
proteinogenic amino acid;
pyruvate family amino acid | EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor;
fundamental metabolite | 1997 | 1997 | 27.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| 9,10-dimethyl-1,2-benzanthracene | | ortho-fused polycyclic arene;
tetraphenes | carcinogenic agent | 1981 | 1981 | 43.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| apomorphine | | aporphine alkaloid | alpha-adrenergic drug;
antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
emetic;
serotonergic drug | 1984 | 1986 | 39.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| methyltestosterone | | 17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
enone | anabolic agent;
androgen;
antineoplastic agent | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| uridine | | uridines | drug metabolite;
fundamental metabolite;
human metabolite | 1983 | 1985 | 39.7 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| leucine | | amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid | algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1985 | 1985 | 39.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| androstenedione | | 17-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid | androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite | 1984 | 1986 | 39.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| phenylalanine | | amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
phenylalanine;
proteinogenic amino acid | algal metabolite;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
Escherichia coli metabolite;
human xenobiotic metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
plant metabolite;
Saccharomyces cerevisiae metabolite | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| cycloheximide | | antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol | anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor | 1980 | 1985 | 41.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| 17-alpha-hydroxyprogesterone | | 17alpha-hydroxy-C21-steroid;
17alpha-hydroxy steroid;
tertiary alpha-hydroxy ketone | human metabolite;
metabolite;
mouse metabolite;
progestin | 1984 | 1985 | 39.5 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| 3-mercaptopropionic acid | | mercaptopropanoic acid | algal metabolite | 1990 | 1990 | 34.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| pyrrolidonecarboxylic acid | | 5-oxoproline;
L-proline derivative;
non-proteinogenic L-alpha-amino acid | algal metabolite | 1984 | 1986 | 38.7 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| pregnenolone | | 20-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
C21-steroid | human metabolite;
mouse metabolite | 1984 | 1985 | 39.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| 20-alpha-dihydroprogesterone | | 20-hydroxypregn-4-en-3-one | human metabolite;
mouse metabolite | 1984 | 1985 | 39.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| testosterone enanthate | | heptanoate ester;
sterol ester | androgen | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| dihydrotestosterone | | 17beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid | androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite | 1983 | 1991 | 38.2 | low | 0 | 5 | 1 | 0 | 0 | 0 |
| pimozide | | benzimidazoles;
heteroarylpiperidine;
organofluorine compound | antidyskinesia agent;
dopaminergic antagonist;
first generation antipsychotic;
H1-receptor antagonist;
serotonergic antagonist | 1983 | 1998 | 36.6 | low | 0 | 7 | 2 | 0 | 0 | 0 |
| mirex | | chlorocarbon;
organochlorine insecticide | persistent organic pollutant | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| tetradecanoylphorbol acetate | | acetate ester;
diester;
phorbol ester;
tertiary alpha-hydroxy ketone;
tetradecanoate ester | antineoplastic agent;
apoptosis inducer;
carcinogenic agent;
mitogen;
plant metabolite;
protein kinase C agonist;
reactive oxygen species generator | 1985 | 1986 | 38.3 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| danazol | | 17beta-hydroxy steroid;
terminal acetylenic compound | anti-estrogen;
estrogen antagonist;
geroprotector | 1983 | 1983 | 41.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| bromocriptine | | indole alkaloid | antidyskinesia agent;
antiparkinson drug;
dopamine agonist;
hormone antagonist | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 8-bromo cyclic adenosine monophosphate | | 3',5'-cyclic purine nucleotide;
adenyl ribonucleotide;
organobromine compound | antidepressant;
protein kinase agonist | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| methyldopa | | L-tyrosine derivative;
non-proteinogenic L-alpha-amino acid | alpha-adrenergic agonist;
antihypertensive agent;
hapten;
peripheral nervous system drug;
sympatholytic agent | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| colforsin | | acetate ester;
cyclic ketone;
labdane diterpenoid;
organic heterotricyclic compound;
tertiary alpha-hydroxy ketone;
triol | adenylate cyclase agonist;
anti-HIV agent;
antihypertensive agent;
plant metabolite;
platelet aggregation inhibitor;
protein kinase A agonist | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| buserelin | | oligopeptide | | 1980 | 1994 | 39.0 | low | 0 | 4 | 1 | 0 | 0 | 0 |
| phorbols | | diterpene;
terpenoid fundamental parent | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| oxytocin | | heterodetic cyclic peptide;
peptide hormone | oxytocic;
vasodilator agent | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| cortodoxone | | deoxycortisol;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone | human metabolite;
mouse metabolite | 1998 | 1998 | 26.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| arachidonic acid | | icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid | Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite | 1982 | 1986 | 40.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| diethylstilbestrol | | olefinic compound;
polyphenol | antifungal agent;
antineoplastic agent;
autophagy inducer;
calcium channel blocker;
carcinogenic agent;
EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
endocrine disruptor;
xenoestrogen | 1982 | 1985 | 40.7 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| phorbol-12,13-didecanoate | | | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| lypressin | | cyclic peptide | | 1984 | 1984 | 40.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| leuprolide | | oligopeptide | anti-estrogen;
antineoplastic agent;
gonadotropin releasing hormone agonist | 1980 | 1985 | 41.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| enclomiphene | | | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| dinoprost | | monocarboxylic acid;
prostaglandins Falpha | human metabolite;
mouse metabolite | 1985 | 1988 | 37.5 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| 6-ketoprostaglandin f1 alpha | | prostaglandins Falpha | human metabolite;
mouse metabolite | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 11-ketotestosterone | | 11-oxo steroid;
17beta-hydroxy steroid;
3-oxo-Delta(4) steroid;
androstanoid | androgen;
human metabolite;
marine xenobiotic metabolite | 1991 | 1998 | 29.5 | low | 0 | 0 | 2 | 0 | 0 | 0 |
| morphine | | morphinane alkaloid;
organic heteropentacyclic compound;
tertiary amino compound | anaesthetic;
drug allergen;
environmental contaminant;
geroprotector;
mu-opioid receptor agonist;
opioid analgesic;
plant metabolite;
vasodilator agent;
xenobiotic | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| goserelin | | organic molecular entity | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| naltrexone | | cyclopropanes;
morphinane-like compound;
organic heteropentacyclic compound | antidote to opioid poisoning;
central nervous system depressant;
environmental contaminant;
mu-opioid receptor antagonist;
xenobiotic | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| lhrh, ala(6)- | | | | 1988 | 1988 | 36.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| lhrh, n-et-alanh2(6)- | | | | 1983 | 1983 | 41.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| medrogestone | | corticosteroid hormone | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| calcimycin | | benzoxazole | | 1985 | 1986 | 38.5 | low | 0 | 4 | 0 | 0 | 0 | 0 |
| iturelix | | | | 1994 | 1994 | 30.0 | low | 0 | 0 | 1 | 0 | 0 | 0 |
| phosphatidylcholines | | 1,2-diacyl-sn-glycero-3-phosphocholine | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| menotropins | | | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| bucladesine | | 3',5'-cyclic purine nucleotide | | 1985 | 1986 | 38.3 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| lhrh, ac-dehydro-pro(1)-4-f-phe(2)-trp(3,6)- | | | | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| trelstar | | | | 1980 | 1980 | 44.0 | low | 0 | 3 | 0 | 0 | 0 | 0 |
| nafarelin | | oligopeptide | anti-estrogen;
gonadotropin releasing hormone agonist | 1985 | 1985 | 39.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| lutrelin acetate | | | | 1982 | 1982 | 42.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| lhrh, pglu(1)-phe(2)-trp(3,6)- | | | | 1984 | 1986 | 39.0 | medium | 0 | 2 | 0 | 0 | 0 | 0 |
| n-ac-(4-cl-phe)(1)-(4-cl-phe)(2)-trp(3)-lys(6)-alanh2(10)-lhrh | | | | 1984 | 1986 | 39.0 | high | 0 | 2 | 0 | 0 | 0 | 0 |
| lhrh, phe(2)-trp(3)-phe(6)- | | | | 1983 | 1983 | 41.0 | medium | 0 | 1 | 0 | 0 | 0 | 0 |
| vasoactive intestinal peptide | | | | 1985 | 1998 | 32.5 | low | 0 | 1 | 1 | 0 | 0 | 0 |
| epidermal growth factor | | | | 1986 | 1986 | 38.0 | low | 0 | 1 | 0 | 0 | 0 | 0 |
| 5-oxo-pro-his-trp-ser-tyr-gly-trp-leu-pro-glynh2 | | | | 1988 | 1988 | 36.0 | medium | 0 | 2 | 0 | 0 | 0 | 0 |
| guanylyl imidodiphosphate | | nucleoside triphosphate analogue | | 1983 | 1985 | 40.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
| phosphorus radioisotopes | | | | 1984 | 1988 | 38.0 | low | 0 | 2 | 0 | 0 | 0 | 0 |
[Effect of a luliberine analogue (surfagon) on food conditioning in rats with different sensitivity to ethanol].Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, , Volume: 83, Issue:3, 1997
[The effect of a luliberin analog on the formation of alcoholic motivation in rats].Fiziologicheskii zhurnal imeni I.M. Sechenova, , Volume: 79, Issue:12, 1993
[Neurotropic effects of luliberin analog in rats with different sensitivity to ethanol].Biulleten' eksperimental'noi biologii i meditsiny, , Volume: 112, Issue:12, 1991
Effect of GnRH treatment during the anovulatory season on multiple ovulation rate and on follicular development during the ensuing pregnancy in mares.Journal of reproduction and fertility, , Volume: 88, Issue:1, 1990
The current status of infertility associated with pelvic endometriosis.Clinical reproduction and fertility, , Volume: 2, Issue:2, 1983
[The experimental use of surfagon, a synthetic analog of luliberin, in follicular ovarian cysts].Problemy endokrinologii, , Volume: 35, Issue:6
Effect of gonadotrophin-releasing hormone analogue (GnRH-A) administration on serum gonadotrophin and steroid levels in patients with polycystic ovarian disease.Acta endocrinologica, , Volume: 111, Issue:2, 1986
Persistence of insulin resistance in polycystic ovarian disease after inhibition of ovarian steroid secretion.Fertility and sterility, , Volume: 45, Issue:3, 1986
Acute ovarian responses to a long-acting agonist of gonadotropin-releasing hormone in ovulatory women and women with polycystic ovarian disease.Fertility and sterility, , Volume: 44, Issue:4, 1985
Gonadotropin-releasing hormone analog-induced patterns of luteinizing hormone secretion in female Wapiti (Cervus elaphus nelsoni) during the breeding season, anestrus, and pregnancy.Biology of reproduction, , Volume: 52, Issue:5, 1995
Effect of GnRH treatment during the anovulatory season on multiple ovulation rate and on follicular development during the ensuing pregnancy in mares.Journal of reproduction and fertility, , Volume: 88, Issue:1, 1990
[Studies on the antipregnancy effect of LHRH-A in mid gestational rats].Yao xue xue bao = Acta pharmaceutica Sinica, , Volume: 25, Issue:7, 1990
Fetal Leydig cell culture--an in vitro system for the study of trophic hormone and GnRH receptors and actions.Journal of steroid biochemistry, , Volume: 23, Issue:5B, 1985
Prolongation of the bovine estrous cycle with a gonadotropin-releasing hormone analog.Biology of reproduction, , Volume: 31, Issue:4, 1984
Relationship between pituitary responsiveness to Gn-RH and number of Gn-RH-binding sites in pituitary glands of beef cows.Journal of reproduction and fertility, , Volume: 71, Issue:1, 1984
Effects of gonadotrophin-releasing hormone on testosterone secretion by fetal and neonatal rat testes in vitro.Molecular and cellular endocrinology, , Volume: 37, Issue:2, 1984
The current status of infertility associated with pelvic endometriosis.Clinical reproduction and fertility, , Volume: 2, Issue:2, 1983
Resistance of the mouse to the antifertility effects of LHRH agonists.Life sciences, , Apr-12, Volume: 30, Issue:15, 1982
Luteinizing hormone-releasing hormone (LHRH) and LHRH agonist termination of pregnancy in hypophysectomized rats: extrapituitary site of action.Endocrinology, , Volume: 108, Issue:1, 1981
Synchronization of oestrus in adult female rats by utilizing the paradoxical effects of an LH-RH agonist.Journal of reproduction and fertility, , Volume: 60, Issue:2, 1980
Biphasic fluctuation of pituitary responsiveness to LH-RH during the rat estrous cycle. Role of endogenous LH-RH and ovarian steroids in its modulation.Neuroendocrinology, , Volume: 31, Issue:1, 1980
Cessation of progesterone secretion by LH-RH in hypophysectomized pregnant and hypophysectomized, prolactin injected pseudopregnant rats.International journal of fertility, , Volume: 25, Issue:3, 1980
[Luteinizing hormone-releasing hormone (LRH) agonist in the treatment of breast cancer, osteosarcoma and prostate carcinoma--analysis of 12 patients].Zhonghua zhong liu za zhi [Chinese journal of oncology], , Volume: 10, Issue:1, 1988
Lack of a direct effect of gonadotropin hormone-releasing hormone agonist on human testicular steroidogenesis.The Journal of clinical endocrinology and metabolism, , Volume: 64, Issue:1, 1987
Kinetics of steroid responsiveness to hCG during chronic inhibition of testicular function by GnRH analogue.Acta endocrinologica, , Volume: 107, Issue:4, 1984
Morphological and enzymatic changes caused by a long-term treatment of female rats with a low dose of gonadoliberin agonist and antagonist.Medical science monitor : international medical journal of experimental and clinical research, , Volume: 18, Issue:8, 2012
Persistence of insulin resistance in polycystic ovarian disease after inhibition of ovarian steroid secretion.Fertility and sterility, , Volume: 45, Issue:3, 1986
Impairment of pituitary and gonadal functions in alloxan-induced diabetic male rats.Molecular and cellular endocrinology, , Volume: 18, Issue:3, 1980
Persistence of insulin resistance in polycystic ovarian disease after inhibition of ovarian steroid secretion.Fertility and sterility, , Volume: 45, Issue:3, 1986
Effect of gonadotrophin-releasing hormone analogue (GnRH-A) administration on serum gonadotrophin and steroid levels in patients with polycystic ovarian disease.Acta endocrinologica, , Volume: 111, Issue:2, 1986
Acute ovarian responses to a long-acting agonist of gonadotropin-releasing hormone in ovulatory women and women with polycystic ovarian disease.Fertility and sterility, , Volume: 44, Issue:4, 1985
[Luteinizing hormone-releasing hormone (LRH) agonist in the treatment of breast cancer, osteosarcoma and prostate carcinoma--analysis of 12 patients].Zhonghua zhong liu za zhi [Chinese journal of oncology], , Volume: 10, Issue:1, 1988
Lack of a direct effect of gonadotropin hormone-releasing hormone agonist on human testicular steroidogenesis.The Journal of clinical endocrinology and metabolism, , Volume: 64, Issue:1, 1987
Kinetics of steroid responsiveness to hCG during chronic inhibition of testicular function by GnRH analogue.Acta endocrinologica, , Volume: 107, Issue:4, 1984
Long-term Use (5)
| Article | Year |
|---|
Expression of cytochrome P450 2C and 3A in female rat liver after long-term administration of gonadoliberin analogs.
International journal of occupational medicine and environmental health, , Volume: 29, Issue:2 | 2016 |
Changes in the subcellular and tissue location of estrogen and progesterone receptors in rat uterus after long-term treatment with analogs of gonadoliberin.
Ginekologia polska, , Volume: 85, Issue:4 | 2014 |
Kinetics of steroid responsiveness to hCG during chronic inhibition of testicular function by GnRH analogue.
Acta endocrinologica, , Volume: 107, Issue:4 | 1984 |
Dissociation between the direct stimulatory and inhibitory effects of a gonadotropin-releasing hormone analog on ovarian functions.
Molecular and cellular endocrinology, , Volume: 31, Issue:2-3 | 1983 |
Lack of a direct effect of gonadotropin hormone-releasing hormone agonist on human testicular steroidogenesis.
The Journal of clinical endocrinology and metabolism, , Volume: 64, Issue:1 | 1987 |
Pharmacokinetics (1)
Bioavailability (4)
| Article | Year |
|---|
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, , Volume: 96, Issue:5 | 2019 |
Pharmacokinetics and Bioavailability of the GnRH Analogs in the Form of Solution and Zn
European journal of drug metabolism and pharmacokinetics, , Volume: 42, Issue:2 | 2017 |
Sustained release and biological availability of dalarelin from the biodegradable coacervate microcapsules.
Farmaco (Societa chimica italiana : 1989), , Volume: 57, Issue:12 | 2002 |
Bioavailability of dalarelin--a superactive GnRH analogue--in rats.
Farmaco (Societa chimica italiana : 1989), , Volume: 54, Issue:11-12 | |
Dosage (6)
| Article | Year |
|---|
Effect of gonadotrophin releasing hormone upon the pattern of steroidogenesis in isolated preovulatory rat follicles.
Acta endocrinologica, , Volume: 105, Issue:1 | 1984 |
Effects of LH-RH and des-Gly10[D-Ala6]LH-RH-ethylamide on plasma gonadotropin levels and oocyte maturation in adult female coho salmon (Oncorhynchus kisutch).
General and comparative endocrinology, , Volume: 49, Issue:3 | 1983 |
Species differences in the sensitivity to a GnRH antagonist.
Contraception, , Volume: 32, Issue:1 | 1985 |
Simultaneous measurement of hormone release and secretagogue binding by individual pituitary cells.
Proceedings of the National Academy of Sciences of the United States of America, , Volume: 84, Issue:15 | 1987 |
Identification of subpopulations of rat granulosa cells: sedimentation properties and hormonal responsiveness.
Endocrinology, , Volume: 117, Issue:3 | 1985 |
Inhibitors of the luteinizing hormone-releasing hormone based upon modifications in the 2, 3, and 6 positions.
Journal of medicinal chemistry, , Volume: 19, Issue:2 | 1976 |
Interactions (1)