erb-041 has been researched along with Pain* in 1 studies
1 other study(ies) available for erb-041 and Pain
| Article | Year |
|---|---|
An estrogen receptor-beta agonist is active in models of inflammatory and chemical-induced pain.
ERB-041 (2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3 benzoxazol-5-ol) is a selective estrogen receptor-beta agonist with activity in rodent models of rheumatoid arthritis and endometriosis. Clinical trials for these diseases are underway: however, the role of estrogen receptor-beta in modulating pain associated with inflammation remains unknown. These studies demonstrate that acutely administered ERB-041 is anti-hyperalgesic in preclinical models of chemical-induced and acute inflammatory pain, thus suggesting that ERB-041 may be useful for modulating pain associated with some types of inflammation. Topics: Animals; Dose-Response Relationship, Drug; Estradiol; Estrogen Receptor beta; Fulvestrant; Hot Temperature; Hyperalgesia; Inflammation; Male; Oxazoles; Pain; Rats; Rats, Sprague-Dawley | 2006 |