ici 204448 has been researched along with Pain in 3 studies
ICI 204448: kappa opioid receptor agonist; structure given in first source
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The present study used assays of pain-related stimulation and depression of behavior in rats to compare effects of 1) two peripherally restricted κ agonists [the tetrapeptide D-Phe-D-Phe-D-Ile-D-Arg-NH(2) (ffir) and the nonpeptidic compound ((R,S)-N-[2-(N-methyl-3,4-dichlorophenylacetamido)-2-(3-carboxyphenyl)-ethyl]pyrrolidine hydrochloride (ICI204448)], 2) a centrally penetrating κ agonist (salvinorin A), and 3) several reference drugs, including a nonsteroidal anti-inflammatory drug (NSAID; ketoprofen)." | 3.78 | Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats. ( Cheng, K; Morrissey, E; Negus, SS; O'Connell, R; Rice, KC, 2012) |
| " This pharmacodynamic phenomenon is referred to in the present work as "teleantagonism"." | 1.35 | Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron. ( Cunha, FQ; Duarte, DB; Ferrari, LF; Ferreira, SH; Funez, MI; Lorenzetti, BB; Parada, CA; Sachs, D, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, V | 1 |
| Guo, D | 1 |
| Cassel, JA | 1 |
| Daubert, JD | 1 |
| Dehaven, RN | 1 |
| Dehaven-Hudkins, DL | 1 |
| Gauntner, EK | 1 |
| Gottshall, SL | 1 |
| Greiner, SL | 1 |
| Koblish, M | 1 |
| Little, PJ | 1 |
| Mansson, E | 1 |
| Maycock, AL | 1 |
| Funez, MI | 1 |
| Ferrari, LF | 1 |
| Duarte, DB | 1 |
| Sachs, D | 1 |
| Cunha, FQ | 1 |
| Lorenzetti, BB | 1 |
| Parada, CA | 1 |
| Ferreira, SH | 1 |
| Negus, SS | 1 |
| O'Connell, R | 1 |
| Morrissey, E | 1 |
| Cheng, K | 1 |
| Rice, KC | 1 |
3 other studies available for ici 204448 and Pain
| Article | Year |
|---|---|
Synthesis and evaluation of novel peripherally restricted kappa-opioid receptor agonists.
Topics: Amides; Analgesics; Animals; Central Nervous System; Drug Evaluation, Preclinical; Heterocyclic Comp | 2005 |
Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Dopamine; Drug I | 2008 |
Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats.
Topics: Animals; Behavior, Animal; Cocaine; Diterpenes, Clerodane; Flupenthixol; Ketoprofen; Male; Oligopept | 2012 |