methylglucamine metrizoate profile

Methylglucamine metrizoate, also known as meglumine diatrizoate, is a water-soluble, non-ionic iodinated contrast agent used in diagnostic imaging. It is a dimer of meglumine (N-methylglucamine) and diatrizoate. The compound is synthesized through a series of chemical reactions involving the reaction of diatrizoic acid with meglumine. Methylglucamine metrizoate works by increasing the radiodensity of tissues and organs, allowing them to be visualized more clearly on X-ray images. It is commonly used in various imaging procedures, including angiography, computed tomography (CT), and myelography. The compound is well-tolerated and has a relatively low risk of adverse effects. It is studied to improve its effectiveness and reduce its potential side effects. The research focuses on developing new formulations and administration methods to optimize its use in different clinical settings.'

methylglucamine metrizoate: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	23664
MeSH ID	M0076067

Synonym
methylglucamine metrizoate
isopaque cerebral
18555-27-6
DTXSID40274748

Excerpt	Reference	Relevance
" The hyperosmolar, ionic contrast medium, meglumine metrizoate, was far more toxic to the endothelium than the nonionic media, metrizamide and iohexol, which are far less hyperosmolar."	( Human endothelial cell culture as an evaluation system for the toxicity of intravascular contrast media. Börsum, T; Laerum, F; Reisvaag, A, )	0.13

Excerpt	Relevance	Reference
" The incidence of eosinophilia was irrespective of dosage or type of RCM."	( Eosinophilia caused by iodinated radiographic contrast media. Kuzmanić, D; Plavsić, B; Rotkvić, I, 1983)	0.27

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	47 (90.38)	18.7374
1990's	5 (9.62)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	24 (37.50%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	7 (10.94%)	4.05%
Observational	0 (0.00%)	0.25%
Other	33 (51.56%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
lactic acid Lactic Acid: A normal intermediate in the fermentation (oxidation, metabolism) of sugar. The concentrated form is used internally to prevent gastrointestinal fermentation. (From Stedman, 26th ed). 2-hydroxypropanoic acid : A 2-hydroxy monocarboxylic acid that is propanoic acid in which one of the alpha-hydrogens is replaced by a hydroxy group.	1.96	1	0	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite
iodine Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..	2.66	3	0	diatomic iodine	nutrient
diatrizoic acid Diatrizoate: A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.. amidotrizoic acid : A member of the class of benzoic acids that is benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, mainly as its N-methylglucamine and sodium salts, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography.	1.96	1	0	acetamides; benzoic acids; organoiodine compound	environmental contaminant; radioopaque medium; xenobiotic
metrizoate Metrizoic Acid: A diagnostic radiopaque that usually occurs as the sodium salt.	9.35	52	20	monocarboxylic acid	radioopaque medium
iohexol Iohexol: An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.. iohexol : A benzenedicarboxamide compound having N-(2,3-dihydroxypropyl)carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an N-(2,3-dihydroxypropyl)acetamido group at the 5-position.	7.88	19	12	benzenedicarboxamide; organoiodine compound	environmental contaminant; radioopaque medium; xenobiotic
iothalamic acid Iothalamic Acid: A contrast medium in diagnostic radiology with properties similar to those of diatrizoic acid. It is used primarily as its sodium and meglumine (IOTHALAMATE MEGLUMINE) salts.	5.91	7	4	organic molecular entity
ioxaglate Ioxaglic Acid: A low-osmolar, ionic contrast medium used in various radiographic procedures.. ioxaglic acid : A benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and an acetyl(methyl)amino group at the 5-position.	4.96	9	1	benzenedicarboxamide; benzoic acids; organoiodine compound	radioopaque medium
sorbitol D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).	3.75	2	1	glucitol	cathartic; Escherichia coli metabolite; food humectant; human metabolite; laxative; metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite; sweetening agent
edetic acid Edetic Acid: A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.	1.97	1	0	ethylenediamine derivative; polyamino carboxylic acid; tetracarboxylic acid	anticoagulant; antidote; chelator; copper chelator; geroprotector
mannitol [no description available]	1.95	1	0	mannitol	allergen; antiglaucoma drug; compatible osmolytes; Escherichia coli metabolite; food anticaking agent; food bulking agent; food humectant; food stabiliser; food thickening agent; hapten; metabolite; osmotic diuretic; sweetening agent
diatrizoate meglumine Diatrizoate Meglumine: A versatile contrast medium used for DIAGNOSTIC X-RAY RADIOLOGY.. meglumine amidotrizoate : The N-methylglucamine salt of amidotrizoic acid. Both the sodium and the meglumine salts of amidotrizoic acid have been widely used as water-soluble radioopaque media in diagnostic radiography. The use of a mixture of the two salts is often preferred, as adverse effects can be reduced.	4.73	7	1	monocarboxylic acid anion	radioopaque medium
meglumine Meglumine: 1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium.. N-methylglucamine : A hexosamine that is D-glucitol in which the hydroxy group at position 1 is substituted by the nitrogen of a methylamino group. A crystalline base, it is used in preparing salts of certain acids for use as diagnostic radiopaque media, while its antimonate is used as an antiprotozoal in the treatment of leishmaniasis.	5.4	8	2	hexosamine; secondary amino compound
b 10610 iodoxamic acid: radiopaque medium used in the diagnosis of gall bladder & bile duct diseases, usually as meglumine salt; minor descriptor (81-86); on-line & INDEX MEDICUS search TRIIODOBENZOIC ACIDS (81-86)	1.96	1	0	organic molecular entity
iopentol [no description available]	3.38	1	1	amidobenzoic acid
iopamidol Iopamidol: A non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiological procedures.. iopamidol : A benzenedicarboxamide compound having N-substituted carbamoyl groups at the 1- and 3-positions, iodo substituents at the 2-, 4- and 6-positions and a (2S)-2-hydroxypropanamido group at the 5-position.	5.65	7	3	benzenedicarboxamide; organoiodine compound; pentol	environmental contaminant; radioopaque medium; xenobiotic
metrizamide Metrizamide: A solute for density gradient centrifugation offering higher maximum solution density without the problems of increased viscosity. It is also used as a resorbable, non-ionic contrast medium.	5.29	13	1	amino sugar
iothalamate meglumine Iothalamate Meglumine: A radiopaque medium used for urography, angiography, venography, and myelography. It is highly viscous and binds to plasma proteins.	3.75	2	1	amidobenzoic acid
meglumine ioxithalamate meglumine ioxithalamate: structure	1.96	1	0
methylglucamine iodoxamate methylglucamine iodoxamate: RN given refers to meglumine salt (2:1)	1.96	1	0
iocarmate meglumine iocarmate meglumine: cpd is iocarmic acid dimeglumine salt; RN given refers to dimeglumine salt; see also iocarmic acid	3.35	1	1

Condition	Relationship Strength	Studies	Trials
Phlegmasia Alba Dolens Inflammation that is characterized by swollen, pale, and painful limb. It is usually caused by DEEP VEIN THROMBOSIS in a FEMORAL VEIN, following PARTURITION or an illness. This condition is also called milk leg or white leg.	3.75	2	1
Thrombophlebitis Inflammation of a vein associated with a blood clot (THROMBUS).	3.75	2	1
Liver Dysfunction [description not available]	3.35	1	1
Liver Diseases Pathological processes of the LIVER.	3.35	1	1
Ache [description not available]	4.44	5	1
Blood Clot [description not available]	3.75	2	1
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	4.44	5	1
Thrombosis Formation and development of a thrombus or blood clot in the blood vessel.	3.75	2	1
Inguinal Hernia [description not available]	2.65	3	0
Hernia, Inguinal An abdominal hernia with an external bulge in the GROIN region. It can be classified by the location of herniation. Indirect inguinal hernias occur through the internal inguinal ring. Direct inguinal hernias occur through defects in the ABDOMINAL WALL (transversalis fascia) in Hesselbach's triangle. The former type is commonly seen in children and young adults; the latter in adults.	2.65	3	0
Arrhythmia [description not available]	3.75	2	1
Arrhythmias, Cardiac Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.	3.75	2	1
Eosinophilia, Tropical [description not available]	1.96	1	0
Eosinophilia Abnormal increase of EOSINOPHILS in the blood, tissues or organs.	1.96	1	0
Ureteral Obstruction Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.	1.95	1	0
Brain Disorders [description not available]	3.35	1	1
Benign Neoplasms, Brain [description not available]	3.35	1	1
Aneurysm, Anterior Cerebral Artery [description not available]	3.35	1	1
Arteriovenous Malformations, Cerebral [description not available]	3.35	1	1
Anterior Circulation Transient Ischemic Attack [description not available]	4.31	2	2
Brain Diseases Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.	3.35	1	1
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	3.35	1	1
Intracranial Aneurysm Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (	3.35	1	1
Intracranial Arteriovenous Malformations Congenital vascular anomalies in the brain characterized by direct communication between an artery and a vein without passing through the CAPILLARIES. The locations and size of the shunts determine the symptoms including HEADACHES; SEIZURES; STROKE; INTRACRANIAL HEMORRHAGES; mass effect; and vascular steal effect.	3.35	1	1
Ischemic Attack, Transient Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)	4.31	2	2
Coronary Heart Disease [description not available]	4.6	6	1
Coronary Disease An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.	4.6	6	1
Albuminuria The presence of albumin in the urine, an indicator of KIDNEY DISEASES.	1.95	1	0
Proteinuria The presence of proteins in the urine, an indicator of KIDNEY DISEASES.	1.95	1	0
Complications of Diabetes Mellitus [description not available]	1.96	1	0
Acute Kidney Failure [description not available]	1.96	1	0
Uremia A clinical syndrome associated with the retention of renal waste products or uremic toxins in the blood. It is usually the result of RENAL INSUFFICIENCY. Most uremic toxins are end products of protein or nitrogen CATABOLISM, such as UREA or CREATININE. Severe uremia can lead to multiple organ dysfunctions with a constellation of symptoms.	1.96	1	0
Acute Kidney Injury Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.	1.96	1	0
Vascular Diseases Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.	1.96	1	0
Left Ventricular Dysfunction [description not available]	3.38	1	1
Ventricular Dysfunction, Left A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.	3.38	1	1
Abnormality, Heart [description not available]	2.36	2	0
Heart Defects, Congenital Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.	2.36	2	0
Aura [description not available]	1.97	1	0
Edema, Pulmonary [description not available]	1.97	1	0
Epilepsy A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)	1.97	1	0
Pulmonary Edema Excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.	1.97	1	0
Cancer of Liver [description not available]	3.76	2	1
Liver Neoplasms Tumors or cancer of the LIVER.	3.76	2	1
Complication, Postoperative [description not available]	1.96	1	0
Postoperative Complications Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.	1.96	1	0
Injuries, Tendon [description not available]	1.97	1	0
Shoulder Injuries Injuries involving the SHOULDERS and SHOULDER JOINT.	1.97	1	0
Coagulation Disorders, Blood [description not available]	3.35	1	1
Central Nervous System Disease [description not available]	3.35	1	1
Blood Coagulation Disorders Hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.	3.35	1	1
Central Nervous System Diseases Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.	3.35	1	1
Blood Pressure, Low [description not available]	1.97	1	0
Hypotension Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.	1.97	1	0
Basilar Artery Insufficiency [description not available]	3.35	1	1
Carcinoma, Intraepithelial [description not available]	1.96	1	0
Cancer of Cervix [description not available]	1.96	1	0
Carcinoma in Situ A lesion with cytological characteristics associated with invasive carcinoma but the tumor cells are confined to the epithelium of origin, without invasion of the basement membrane.	1.96	1	0
Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX.	1.96	1	0
Female Genital Diseases [description not available]	1.96	1	0
Genital Diseases, Male Pathological processes involving the male reproductive tract (GENITALIA, MALE).	1.96	1	0
Femoral Hernia [description not available]	1.96	1	0
Muscle Disorders [description not available]	1.96	1	0
Urinary Tract Diseases [description not available]	1.96	1	0
Bone Diseases Diseases of BONES.	1.96	1	0
Genital Diseases, Female Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).	1.96	1	0
Muscular Diseases Acquired, familial, and congenital disorders of SKELETAL MUSCLE and SMOOTH MUSCLE.	1.96	1	0

methylglucamine metrizoate

Description

Cross-References

Synonyms (4)

Research Excerpts

Toxicity

Dosage Studied

Research

Studies (52)

Market Indicators

Research Demand Index: 9.79

Study Types