pyrazines and Pain
pyrazines has been researched along with Pain in 42 studies
Research
Studies (42)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.14) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 17 (40.48) | 29.6817 |
| 2010's | 15 (35.71) | 24.3611 |
| 2020's | 7 (16.67) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Giniatullin, R; Hämäläinen, RH; Mikhailov, N; Plotnikova, L; Singh, P | 1 |
| Fasipe, TA; Kavanagh, PL; Wun, T | 1 |
| Aurran-Schleinitz, T; Chen, DY; Cheson, BD; D'Sa, S; Forconi, F; Frigault, MM; Furman, RR; Greenwald, D; Hamdy, A; Iyengar, S; Izumi, R; Kastritis, E; Kersten, MJ; Kothari, J; Lee, SK; McCarthy, H; Minnema, MC; Mittag, D; Owen, RG; Patel, P; Rule, S; Thomas, SK; Tournilhac, O; Walter, H; Wei, H; Zinzani, PL | 1 |
| Steinberg, MH | 1 |
| Ahn, IE; Cheung, J; Covey, T; Farooqui, MZH; Gaglione, EM; Gulrajani, M; Hamdy, A; Harris, HM; Herman, SEM; Izumi, R; Kendall, EK; Maric, I; Nierman, P; Patel, P; Pittaluga, S; Pleyer, C; Stetler-Stevenson, M; Sun, C; Wang, MH; Wiestner, A; Yuan, CM | 1 |
| Harrasser, N; Suren, C; V Eisenhart-Rothe, R | 1 |
| Arantes, ALF; Cazuza, RA; Leite-Panissi, CRA; Pol, O | 1 |
| Hu, C; Huang, Z; Li, Y; Li, Z; Liu, C; Zhang, K; Zuo, Z | 1 |
| Bartlett, NL; Beck, JT; Cherfi, A; Cheung, W; Collins, RH; Fan, J; Fanning, SR; Goy, A; Johnston, PB; Kaminski, MS; Kaya, H; Klimovsky, J; Lister, J; O'Connor, OA; Popplewell, LL; Robeva, A; Tuscano, JM; Wang, M; Winter, JN | 1 |
| Fujita, T; Kumamoto, E; Piao, LH; Yu, T | 1 |
| Fischer, MJM; Namer, B; Reeh, PW; Schwarz, MG | 1 |
| Colvin, LA; Fallon, M; Fleetwood-Walker, SM; Johnson, PR; Mitchell, R | 1 |
| Bilodeau, MT; Bock, MG; Cato, MJ; Chang, RK; Cook, SP; Di Marco, CN; Dipardo, RM; Hartman, GD; Jovanovska, A; Kane, SA; Kuduk, SD; Leitl, M; Spencer, RH; Urban, MO | 1 |
| Bonnefous, C; Chen, X; Hassig, CA; Nguyen, PM; Noble, SA; Payne, JE; Rao, TS; Rix, P; Roppe, J; Rozenkrants, N; Sablad, M; Severance, D; Shiau, AK; Smith, ND; Symons, KT; Walsh, JP; Wang, L; Yazdani, N; Zhang, Y; Zhuang, H | 1 |
| Knopf, KB; Moretto, JC; Waller, JM | 1 |
| Avezza, F; Canta, A; Carozzi, VA; Cavaletti, G; Ceresa, C; Chiorazzi, A; Crippa, L; Gilardini, A; Marmiroli, P; Meregalli, C; Oggioni, N | 1 |
| Chang, DZ; Chiang, J; Delasalle, K; Fang, W; Forman, A; Garcia, MK; Guo, Y; Lu, J; Romaguera, J; Wang, M; Yi, Q; Zhou, Y | 1 |
| Alé, A; Bruna, J; Monbaliu, J; Navarro, X; Silverman, L; Udina, E; Vilches, JJ; Vynckier, A | 1 |
| Bakthavatchalam, R; Blum, CA; Boyce, S; Brielmann, H; Burnaby-Davies, N; Caldwell, T; Capitosti, S; Chenard, BL; Conley, R; Cortright, D; Crandall, M; De Lombaert, S; Hodgetts, KJ; Jones, AB; Kershaw, MT; Krause, JE; Martin, WJ; Mason, G; Matson, D; Murphy, BA; Perrett, H; Rycroft, W; Zheng, X | 1 |
| Anderson, KC; Avigan, DE; Delaney, C; Doss, D; Esseltine, DL; Ghobrial, IM; Hideshima, T; Jagannath, S; Jakubowiak, AJ; Joyce, R; Kaster, S; Kaufman, JL; Knight, R; Lonial, S; Lunde, LE; Mazumder, A; Mitsiades, CS; Munshi, NC; Raje, NS; Richardson, PG; Schlossman, RL; Vesole, DH; Warren, DL; Weller, E; Xie, W | 1 |
| Bölcskei, K; Dézsi, L; Horváth, C; Kis-Varga, A; Petho, G; Szentirmay, E; Szolcsányi, J; Tékus, V; Visegrády, A | 1 |
| Alexandre-Moreira, MS; Augusto, CV; Barreiro, EJ; da Silva, YK; de Albuquerque Melo, GM; de Castro Barbosa, ML; de Lima Matos Freire Dias, T; de Queiroz, AC; Júnior, WB; Lima, LM | 1 |
| Bakthavatchalam, R; Blum, CA; Boyce, S; Brian Jones, A; Caldwell, T; Capitosti, S; Chenard, BL; Cortright, D; Crandall, M; Hodgetts, KJ; Krause, JE; Murphy, BA; Zheng, X | 1 |
| Bonnefous, C; Hassig, CA; Nguyen, PM; Noble, SA; Payne, JE; Rao, TS; Rix, P; Rozenkrants, N; Sablad, M; Shiau, AK; Smith, ND; Symons, KT; Wang, L; Yazdani, N; Zhang, Y | 1 |
| Appenzeller, M; Bigliardi, P; Buclin, T; Grouzmann, E; Pannatier, A | 1 |
| Boyette-Davis, JA; Cata, JP; Dougherty, PM; Driver, LC; Kennedy, WR; Wendelschafer-Crabb, G; Zhang, H | 1 |
| Bennett, GJ; Xiao, WH; Zheng, H | 1 |
| Bristol, DR; Harrison, JE; Mark, L; Pomonis, JD; Valenzano, KJ; Walker, K | 1 |
| Gao, Y; Liang, SD; Mu, SN; Xu, BH; Xu, CS | 1 |
| Ambo, A; Bryant, SD; Jinsmaa, Y; Lazarus, LH; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y | 1 |
| Fujiuchi, A; Hara, T; Imai, A; Kanai, Y; Nakazato, E | 1 |
| De Raeve, H; Lambert, J; Rombouts, S; Schroyens, W; Van de Velde, A; Van de Voorde, K; Van Regenmortel, N | 1 |
| Christoph, T; Erdmann, VA; Frank, R; Gillen, C; Grünweller, A; Kurreck, J; Mika, J; Schäfer, MK; Wade, EJ; Weihe, E | 1 |
| Dodd, PG; Gayton, S; Greener, BS; Harbottle, GW; Mantell, SJ; Maw, GN; Osborne, SA; Owen, DR; Rees, H; Ringer, TJ; Rodriguez-Lens, M; Smith, GF | 1 |
| Burton, AW; Cata, JP; Dougherty, PM; Giralt, S; Villareal, H; Weng, HR | 1 |
| Goto, F; Ito, N; Obata, H; Saito, S; Sasaki, M | 1 |
| Adams, W; Adedoyin, A; Barry, A; Cummons, TA; Harrison, J; Jones, PG; Leventhal, L; Lu, P; Piesla, MJ; Ramdass, R; Schantz, J; Smith, VA; Spangler, TB; Strassle, BW; Sullivan, NR; Sun, SC; Uveges, AJ; Whiteside, GT | 1 |
| Cavaletti, G; Nobile-Orazio, E | 1 |
| Kita, Y; Nakazato-Imasato, E; Tanimoto-Mori, S; Toide, K | 1 |
| Daffalla, AA; Dixon, HG; el Igail, AB; el Tayeb, M; Fenwick, A; Kardaman, MW | 1 |
| Benoit, JP; Benoit, P | 1 |
| Raymann, F | 1 |
Reviews
2 review(s) available for pyrazines and Pain
| Article | Year |
|---|---|
Sickle Cell Disease: A Review.
Topics: Adult; Anemia, Sickle Cell; Antibodies, Monoclonal, Humanized; Antisickling Agents; Benzaldehydes; Child; Glutamine; Hematologic Agents; Hematopoietic Stem Cell Transplantation; Humans; Hydroxyurea; Infant, Newborn; Neonatal Screening; Pain; Pyrazines; Pyrazoles; Transition to Adult Care; United States | 2022 |
Multiple myeloma, painful neuropathy, acupuncture?
Topics: Acupuncture Therapy; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Humans; Multiple Myeloma; Pain; Pain Management; Peripheral Nervous System Diseases; Pyrazines; Thalidomide | 2009 |
Trials
7 trial(s) available for pyrazines and Pain
| Article | Year |
|---|---|
Acalabrutinib monotherapy in patients with Waldenström macroglobulinemia: a single-arm, multicentre, phase 2 study.
Topics: Agammaglobulinaemia Tyrosine Kinase; Aged; Antineoplastic Agents; Benzamides; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Molecular Targeted Therapy; Myeloid Differentiation Factor 88; Neoplasm Proteins; Neutropenia; Pain; Protein Kinase Inhibitors; Pyrazines; Quality of Life; Recurrence; Respiratory Tract Infections; Salvage Therapy; Treatment Outcome; Waldenstrom Macroglobulinemia | 2020 |
Clinical and biological implications of target occupancy in CLL treated with the BTK inhibitor acalabrutinib.
Topics: Agammaglobulinaemia Tyrosine Kinase; Aged; Aged, 80 and over; Antineoplastic Agents; Benzamides; Drug Administration Schedule; Enzyme Induction; Female; Headache; Hematologic Diseases; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm Proteins; Pain; Progression-Free Survival; Protein Kinase Inhibitors; Pyrazines; RNA-Seq; RNA, Messenger; RNA, Neoplasm; Transcriptome; Treatment Outcome | 2020 |
Everolimus for patients with mantle cell lymphoma refractory to or intolerant of bortezomib: multicentre, single-arm, phase 2 study.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Combined Modality Therapy; Disease-Free Survival; Drug Resistance, Neoplasm; Everolimus; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Kaplan-Meier Estimate; Lymphoma, Mantle-Cell; Male; Middle Aged; Pain; Pneumonia; Pyrazines; Salvage Therapy; Sirolimus; Treatment Outcome | 2014 |
TRPA1 and TRPV1 Antagonists Do Not Inhibit Human Acidosis-Induced Pain.
Topics: Acid Sensing Ion Channel Blockers; Acidosis; Adult; Amiloride; Analgesics; Analysis of Variance; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Oximes; Pain; Pain Measurement; Pyrazines; Pyridines; TRPA1 Cation Channel; TRPV Cation Channels | 2017 |
Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Combined Modality Therapy; Dexamethasone; Fatigue; Hematologic Diseases; Humans; Lenalidomide; Multiple Myeloma; Pain; Pyrazines; Remission Induction; Sensation Disorders; Stem Cell Transplantation; Survival Analysis; Thalidomide; Treatment Outcome | 2010 |
Substance P-induced skin inflammation is not modulated by a single dose of sitagliptin in human volunteers.
Topics: Capsaicin; Carbonated Beverages; Cross-Over Studies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Eruptions; Edema; Erythema; Humans; Injections, Intradermal; Male; Pain; Pyrazines; Sitagliptin Phosphate; Skin; Substance P; Triazoles; Vasodilation | 2011 |
Dose-finding trial using Oltipraz to treat schoolchildren infected with Schistosoma mansoni in Gezira, Sudan.
Topics: Abdomen; Administration, Oral; Child; Clinical Trials as Topic; Feces; Fingers; Follow-Up Studies; Humans; Pain; Parasite Egg Count; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiones; Thiophenes; Vision Disorders | 1985 |
Other Studies
33 other study(ies) available for pyrazines and Pain
| Article | Year |
|---|---|
Functional Characterization of Mechanosensitive Piezo1 Channels in Trigeminal and Somatic Nerves in a Neuron-on-Chip Model.
Topics: Animals; Ganglia, Spinal; Hyperalgesia; Ion Channels; Lab-On-A-Chip Devices; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Nerve Tissue; Neurons; Pain; Peripheral Nervous System; Pyrazines; Thiadiazoles; Touch; Trigeminal Nerve | 2022 |
Treating sickle cell anemia: A new era dawns.
Topics: Anemia, Sickle Cell; Antibodies, Monoclonal, Humanized; Benzaldehydes; Child; Fetal Hemoglobin; Forecasting; Gene Expression Regulation; Genetic Therapy; Hematopoietic Stem Cell Transplantation; Humans; Hydroxyurea; Hypoxia, Brain; Infant; P-Selectin; Pain; Pyrazines; Pyrazoles; Therapies, Investigational | 2020 |
[75/f-increasing pain with knee TEP : Preparation for the medical specialist examination-case 5].
Topics: Humans; Knee Joint; Medicine; Pain; Pyrazines; Specialization | 2021 |
HO-CO pathway activation may be associated with hippocampal μ and δ opioid receptors in inhibiting inflammatory pain aversiveness and nociception in WT but not NOS2-KO mice.
Topics: Animals; Avoidance Learning; Carbon Monoxide; Heme Oxygenase (Decyclizing); Hippocampus; Male; Mice; Mice, Knockout; Nociception; Organometallic Compounds; Pain; Pain Measurement; Pyrazines; Pyrroles; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction | 2021 |
Ligustrazine Enhances the Hypnotic and Analgesic Effect of Ketamine in Mice.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Hypnotics and Sedatives; Injections, Intraperitoneal; Ketamine; Male; Mice, Inbred C57BL; Pain; Pyrazines | 2018 |
Presynaptic facilitation by tetracaine of glutamatergic spontaneous excitatory transmission in the rat spinal substantia gelatinosa - Involvement of TRPA1 channels.
Topics: Acetanilides; Amides; Anesthetics, Local; Animals; Bupivacaine; Capsaicin; Excitatory Postsynaptic Potentials; Glutamic Acid; Levobupivacaine; Male; Neurotransmitter Agents; Pain; Patch-Clamp Techniques; Presynaptic Terminals; Prilocaine; Purines; Pyrazines; Pyridines; Rats, Sprague-Dawley; Ropivacaine; Ruthenium Red; Substantia Gelatinosa; Tetracaine; Tetrodotoxin; Tissue Culture Techniques; TRPA1 Cation Channel; TRPC Cation Channels | 2017 |
From bench to bedside: a case of rapid reversal of bortezomib-induced neuropathic pain by the TRPM8 activator, menthol.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Boronic Acids; Bortezomib; Dose-Response Relationship, Drug; Female; Humans; Male; Menthol; Middle Aged; Multiple Myeloma; Pain; Peripheral Nervous System Diseases; Protease Inhibitors; Pyrazines; TRPM Cation Channels | 2008 |
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
Topics: Acid Sensing Ion Channels; Acidosis; Amiloride; Amines; Animals; Chemistry, Pharmaceutical; Drug Design; Electrophysiology; Inhibitory Concentration 50; Male; Models, Chemical; Nerve Tissue Proteins; Pain; Pyrazines; Rats; Rats, Sprague-Dawley; Sodium Channels | 2009 |
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
Topics: Administration, Oral; Animals; Cell Line; Constriction, Pathologic; Disease Models, Animal; Drug Discovery; Enzyme Inhibitors; Fluoroquinolones; Formaldehyde; Humans; Inhibitory Concentration 50; Lipopolysaccharides; Mice; Nitric Oxide Synthase Type II; Pain; Protein Multimerization; Protein Structure, Quaternary; Pyrazines; Quinolones; Structure-Activity Relationship; Substrate Specificity | 2009 |
Multiple significant bortezomib-related toxicities in one patient: case report and literature review.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Doxorubicin; Humans; Male; Multiple Myeloma; Pain; Peripheral Nervous System Diseases; Pruritus; Pyrazines; Testis | 2009 |
Bortezomib-induced painful neuropathy in rats: a behavioral, neurophysiological and pathological study in rats.
Topics: Animals; Antineoplastic Agents; Behavior, Animal; Blood Cell Count; Blood Chemical Analysis; Body Weight; Boronic Acids; Bortezomib; Dose-Response Relationship, Drug; Female; Hot Temperature; Neural Conduction; Neurotoxicity Syndromes; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pyrazines; Rats; Rats, Wistar; Sciatic Nerve | 2010 |
Neurophysiological, histological and immunohistochemical characterization of bortezomib-induced neuropathy in mice.
Topics: Action Potentials; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Electrophysiology; Female; Ganglia, Spinal; Immunohistochemistry; Mice; Microscopy, Electron; Motor Neurons; Myelin Sheath; Nerve Fibers, Unmyelinated; Neural Conduction; Pain; Peripheral Nervous System Diseases; Protease Inhibitors; Pyrazines; Sciatic Nerve; Sensory Receptor Cells; Skin; Tibial Nerve | 2010 |
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
Topics: Analgesics; Animals; Biological Availability; Capsaicin; Chlorocebus aethiops; COS Cells; Hot Temperature; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Rats; Structure-Activity Relationship; TRPV Cation Channels | 2010 |
Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath.
Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cold Temperature; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Pain; Pyrazines; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Urea | 2010 |
Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Ear; Edema; Female; Freund's Adjuvant; Hydrazones; Male; Mice; Pain; Peritonitis; Pyrazines; Rats; Rats, Wistar; Zymosan | 2010 |
Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.
Topics: Administration, Oral; Animals; Dogs; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Macaca mulatta; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Rats; TRPV Cation Channels | 2010 |
Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective
Topics: Administration, Oral; Analgesics; Animals; Cell Line; Drug Tolerance; Fluoroquinolones; Humans; In Vitro Techniques; Mice; Microsomes, Liver; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pain; Pain Measurement; Peripheral Nervous System Diseases; Protein Multimerization; Pyrazines; Rotarod Performance Test; Structure-Activity Relationship | 2010 |
Follow-up psychophysical studies in bortezomib-related chemoneuropathy patients.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pilot Projects; Pyrazines | 2011 |
Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy.
Topics: Acetylcarnitine; Activating Transcription Factor 3; Adenosine Triphosphate; Analysis of Variance; Animals; Antineoplastic Agents; Axons; Boronic Acids; Bortezomib; Citrate (si)-Synthase; Disease Models, Animal; Electron Transport Complex II; Ganglia, Spinal; Hyperalgesia; Male; Mitochondria; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Pyrazines; Rats; Rats, Sprague-Dawley; Schwann Cells; Sciatic Nerve; Time Factors; Ubiquitin Thiolesterase | 2012 |
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
Topics: Analgesics; Animals; Ataxia; Capsaicin; Hyperalgesia; Inflammation; Male; Nerve Tissue; Pain; Pain Threshold; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2003 |
Effect of tetramethylpyrazine on acute nociception mediated by signaling of P2X receptor activation in rat.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spinal; Hindlimb; Injections, Subcutaneous; Male; Membrane Potentials; Neurons, Afferent; Pain; Purinergic P2 Receptor Agonists; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X | 2004 |
Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Guinea Pigs; Male; Mice; Molecular Mimicry; Morphine; Pain; Pyrazines; Receptors, Opioid, mu; Tyrosine | 2004 |
Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats.
Topics: Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Capsaicin; In Vitro Techniques; Injections, Spinal; Male; Nerve Tissue Proteins; Neuropeptides; Pain; Pain Measurement; Physical Stimulation; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Substance P; TRPV Cation Channels; Up-Regulation | 2005 |
Bortezomib-induced Sweet's syndrome.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Drug Administration Schedule; Erectile Dysfunction; Humans; Immunosuppressive Agents; Male; Melphalan; Methylprednisolone; Multiple Myeloma; Pain; Peripheral Nervous System Diseases; Prednisolone; Protease Inhibitors; Pyrazines; Recurrence; Sleep Initiation and Maintenance Disorders; Sweet Syndrome; Testicular Diseases | 2005 |
Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo.
Topics: Animals; Base Sequence; Capsaicin; Chlorocebus aethiops; Colitis; COS Cells; Disease Models, Animal; Humans; Male; Mice; Molecular Sequence Data; Nervous System Diseases; Pain; Pyrazines; Pyridines; Rats; RNA Interference; Sequence Alignment; Sequence Homology, Amino Acid; TRPV Cation Channels | 2006 |
Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.
Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry, Physical; CHO Cells; Chronic Disease; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Glutamic Acid; Pain; Pyrazines; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 2007 |
Quantitative sensory findings in patients with bortezomib-induced pain.
Topics: Aged; Antineoplastic Agents; Boronic Acids; Bortezomib; Chronic Disease; Cold Temperature; Female; Hot Temperature; Humans; Lymphoma, B-Cell; Male; Middle Aged; Multiple Myeloma; Pain; Pain Measurement; Pain Threshold; Psychomotor Performance; Pyrazines; Sensation; Sensation Disorders; Thermosensing; Touch | 2007 |
Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT2C receptor agonists in the rats with peripheral nerve injury.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Atropine; Injections, Spinal; Ligation; Male; Muscarinic Antagonists; Norepinephrine; Pain; Peripheral Nervous System Diseases; Physical Stimulation; Piperazines; Pyrazines; Rats; Rats, Wistar; Serotonin 5-HT2 Receptor Agonists; Spinal Cord; Spinal Nerves; Touch; Yohimbine | 2007 |
Pharmacological characterization of the muscarinic agonist (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983) in in vitro and in vivo models of chronic pain.
Topics: Animals; Biological Availability; Bridged-Ring Compounds; Chronic Disease; Disease Models, Animal; Inflammation; Inhibitory Concentration 50; Muscarinic Agonists; Pain; Pyrazines; Rats; Receptors, Muscarinic | 2007 |
Bortezomib-induced peripheral neurotoxicity: still far from a painless gain.
Topics: Animals; Boronic Acids; Bortezomib; Humans; Neurotoxicity Syndromes; Pain; Pyrazines | 2007 |
Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Chronic Disease; Cold Temperature; Constriction, Pathologic; Disease Models, Animal; Diterpenes; gamma-Aminobutyric Acid; Male; Mexiletine; Morphine; Nerve Fibers, Unmyelinated; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pregabalin; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Nerve; Sodium Channel Blockers; TRPV Cation Channels | 2008 |
[Clinical study of the anti-inflammatory agent: carudol].
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Cellulitis; Edema; Female; Humans; Jaw Fractures; Joint Diseases; Male; Middle Aged; Osteitis; Pain; Postoperative Care; Preoperative Care; Prognosis; Pyrazines; Surgery, Plastic; Temporomandibular Joint; Tooth Extraction | 1972 |
[Pain from the viewpoint of the general practitioner. Experiences with a new analgesic].
Topics: Adolescent; Adult; Aged; Amobarbital; Analgesics; Antipyrine; Caffeine; Family Practice; Humans; Middle Aged; Pain; Phenazines; Pyrazines | 1969 |