Page last updated: 2024-08-21

pyrazines and Pain

pyrazines has been researched along with Pain in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19903 (7.14)18.7374
1990's0 (0.00)18.2507
2000's17 (40.48)29.6817
2010's15 (35.71)24.3611
2020's7 (16.67)2.80

Authors

AuthorsStudies
Giniatullin, R; Hämäläinen, RH; Mikhailov, N; Plotnikova, L; Singh, P1
Fasipe, TA; Kavanagh, PL; Wun, T1
Aurran-Schleinitz, T; Chen, DY; Cheson, BD; D'Sa, S; Forconi, F; Frigault, MM; Furman, RR; Greenwald, D; Hamdy, A; Iyengar, S; Izumi, R; Kastritis, E; Kersten, MJ; Kothari, J; Lee, SK; McCarthy, H; Minnema, MC; Mittag, D; Owen, RG; Patel, P; Rule, S; Thomas, SK; Tournilhac, O; Walter, H; Wei, H; Zinzani, PL1
Steinberg, MH1
Ahn, IE; Cheung, J; Covey, T; Farooqui, MZH; Gaglione, EM; Gulrajani, M; Hamdy, A; Harris, HM; Herman, SEM; Izumi, R; Kendall, EK; Maric, I; Nierman, P; Patel, P; Pittaluga, S; Pleyer, C; Stetler-Stevenson, M; Sun, C; Wang, MH; Wiestner, A; Yuan, CM1
Harrasser, N; Suren, C; V Eisenhart-Rothe, R1
Arantes, ALF; Cazuza, RA; Leite-Panissi, CRA; Pol, O1
Hu, C; Huang, Z; Li, Y; Li, Z; Liu, C; Zhang, K; Zuo, Z1
Bartlett, NL; Beck, JT; Cherfi, A; Cheung, W; Collins, RH; Fan, J; Fanning, SR; Goy, A; Johnston, PB; Kaminski, MS; Kaya, H; Klimovsky, J; Lister, J; O'Connor, OA; Popplewell, LL; Robeva, A; Tuscano, JM; Wang, M; Winter, JN1
Fujita, T; Kumamoto, E; Piao, LH; Yu, T1
Fischer, MJM; Namer, B; Reeh, PW; Schwarz, MG1
Colvin, LA; Fallon, M; Fleetwood-Walker, SM; Johnson, PR; Mitchell, R1
Bilodeau, MT; Bock, MG; Cato, MJ; Chang, RK; Cook, SP; Di Marco, CN; Dipardo, RM; Hartman, GD; Jovanovska, A; Kane, SA; Kuduk, SD; Leitl, M; Spencer, RH; Urban, MO1
Bonnefous, C; Chen, X; Hassig, CA; Nguyen, PM; Noble, SA; Payne, JE; Rao, TS; Rix, P; Roppe, J; Rozenkrants, N; Sablad, M; Severance, D; Shiau, AK; Smith, ND; Symons, KT; Walsh, JP; Wang, L; Yazdani, N; Zhang, Y; Zhuang, H1
Knopf, KB; Moretto, JC; Waller, JM1
Avezza, F; Canta, A; Carozzi, VA; Cavaletti, G; Ceresa, C; Chiorazzi, A; Crippa, L; Gilardini, A; Marmiroli, P; Meregalli, C; Oggioni, N1
Chang, DZ; Chiang, J; Delasalle, K; Fang, W; Forman, A; Garcia, MK; Guo, Y; Lu, J; Romaguera, J; Wang, M; Yi, Q; Zhou, Y1
Alé, A; Bruna, J; Monbaliu, J; Navarro, X; Silverman, L; Udina, E; Vilches, JJ; Vynckier, A1
Bakthavatchalam, R; Blum, CA; Boyce, S; Brielmann, H; Burnaby-Davies, N; Caldwell, T; Capitosti, S; Chenard, BL; Conley, R; Cortright, D; Crandall, M; De Lombaert, S; Hodgetts, KJ; Jones, AB; Kershaw, MT; Krause, JE; Martin, WJ; Mason, G; Matson, D; Murphy, BA; Perrett, H; Rycroft, W; Zheng, X1
Anderson, KC; Avigan, DE; Delaney, C; Doss, D; Esseltine, DL; Ghobrial, IM; Hideshima, T; Jagannath, S; Jakubowiak, AJ; Joyce, R; Kaster, S; Kaufman, JL; Knight, R; Lonial, S; Lunde, LE; Mazumder, A; Mitsiades, CS; Munshi, NC; Raje, NS; Richardson, PG; Schlossman, RL; Vesole, DH; Warren, DL; Weller, E; Xie, W1
Bölcskei, K; Dézsi, L; Horváth, C; Kis-Varga, A; Petho, G; Szentirmay, E; Szolcsányi, J; Tékus, V; Visegrády, A1
Alexandre-Moreira, MS; Augusto, CV; Barreiro, EJ; da Silva, YK; de Albuquerque Melo, GM; de Castro Barbosa, ML; de Lima Matos Freire Dias, T; de Queiroz, AC; Júnior, WB; Lima, LM1
Bakthavatchalam, R; Blum, CA; Boyce, S; Brian Jones, A; Caldwell, T; Capitosti, S; Chenard, BL; Cortright, D; Crandall, M; Hodgetts, KJ; Krause, JE; Murphy, BA; Zheng, X1
Bonnefous, C; Hassig, CA; Nguyen, PM; Noble, SA; Payne, JE; Rao, TS; Rix, P; Rozenkrants, N; Sablad, M; Shiau, AK; Smith, ND; Symons, KT; Wang, L; Yazdani, N; Zhang, Y1
Appenzeller, M; Bigliardi, P; Buclin, T; Grouzmann, E; Pannatier, A1
Boyette-Davis, JA; Cata, JP; Dougherty, PM; Driver, LC; Kennedy, WR; Wendelschafer-Crabb, G; Zhang, H1
Bennett, GJ; Xiao, WH; Zheng, H1
Bristol, DR; Harrison, JE; Mark, L; Pomonis, JD; Valenzano, KJ; Walker, K1
Gao, Y; Liang, SD; Mu, SN; Xu, BH; Xu, CS1
Ambo, A; Bryant, SD; Jinsmaa, Y; Lazarus, LH; Okada, Y; Sasaki, Y; Shiotani, K; Tsuda, Y1
Fujiuchi, A; Hara, T; Imai, A; Kanai, Y; Nakazato, E1
De Raeve, H; Lambert, J; Rombouts, S; Schroyens, W; Van de Velde, A; Van de Voorde, K; Van Regenmortel, N1
Christoph, T; Erdmann, VA; Frank, R; Gillen, C; Grünweller, A; Kurreck, J; Mika, J; Schäfer, MK; Wade, EJ; Weihe, E1
Dodd, PG; Gayton, S; Greener, BS; Harbottle, GW; Mantell, SJ; Maw, GN; Osborne, SA; Owen, DR; Rees, H; Ringer, TJ; Rodriguez-Lens, M; Smith, GF1
Burton, AW; Cata, JP; Dougherty, PM; Giralt, S; Villareal, H; Weng, HR1
Goto, F; Ito, N; Obata, H; Saito, S; Sasaki, M1
Adams, W; Adedoyin, A; Barry, A; Cummons, TA; Harrison, J; Jones, PG; Leventhal, L; Lu, P; Piesla, MJ; Ramdass, R; Schantz, J; Smith, VA; Spangler, TB; Strassle, BW; Sullivan, NR; Sun, SC; Uveges, AJ; Whiteside, GT1
Cavaletti, G; Nobile-Orazio, E1
Kita, Y; Nakazato-Imasato, E; Tanimoto-Mori, S; Toide, K1
Daffalla, AA; Dixon, HG; el Igail, AB; el Tayeb, M; Fenwick, A; Kardaman, MW1
Benoit, JP; Benoit, P1
Raymann, F1

Reviews

2 review(s) available for pyrazines and Pain

ArticleYear
Sickle Cell Disease: A Review.
    JAMA, 2022, 07-05, Volume: 328, Issue:1

    Topics: Adult; Anemia, Sickle Cell; Antibodies, Monoclonal, Humanized; Antisickling Agents; Benzaldehydes; Child; Glutamine; Hematologic Agents; Hematopoietic Stem Cell Transplantation; Humans; Hydroxyurea; Infant, Newborn; Neonatal Screening; Pain; Pyrazines; Pyrazoles; Transition to Adult Care; United States

2022
Multiple myeloma, painful neuropathy, acupuncture?
    American journal of clinical oncology, 2009, Volume: 32, Issue:3

    Topics: Acupuncture Therapy; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Humans; Multiple Myeloma; Pain; Pain Management; Peripheral Nervous System Diseases; Pyrazines; Thalidomide

2009

Trials

7 trial(s) available for pyrazines and Pain

ArticleYear
Acalabrutinib monotherapy in patients with Waldenström macroglobulinemia: a single-arm, multicentre, phase 2 study.
    The Lancet. Haematology, 2020, Volume: 7, Issue:2

    Topics: Agammaglobulinaemia Tyrosine Kinase; Aged; Antineoplastic Agents; Benzamides; Female; Gastrointestinal Diseases; Humans; Male; Middle Aged; Molecular Targeted Therapy; Myeloid Differentiation Factor 88; Neoplasm Proteins; Neutropenia; Pain; Protein Kinase Inhibitors; Pyrazines; Quality of Life; Recurrence; Respiratory Tract Infections; Salvage Therapy; Treatment Outcome; Waldenstrom Macroglobulinemia

2020
Clinical and biological implications of target occupancy in CLL treated with the BTK inhibitor acalabrutinib.
    Blood, 2020, 07-02, Volume: 136, Issue:1

    Topics: Agammaglobulinaemia Tyrosine Kinase; Aged; Aged, 80 and over; Antineoplastic Agents; Benzamides; Drug Administration Schedule; Enzyme Induction; Female; Headache; Hematologic Diseases; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm Proteins; Pain; Progression-Free Survival; Protein Kinase Inhibitors; Pyrazines; RNA-Seq; RNA, Messenger; RNA, Neoplasm; Transcriptome; Treatment Outcome

2020
Everolimus for patients with mantle cell lymphoma refractory to or intolerant of bortezomib: multicentre, single-arm, phase 2 study.
    British journal of haematology, 2014, Volume: 165, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Combined Modality Therapy; Disease-Free Survival; Drug Resistance, Neoplasm; Everolimus; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Kaplan-Meier Estimate; Lymphoma, Mantle-Cell; Male; Middle Aged; Pain; Pneumonia; Pyrazines; Salvage Therapy; Sirolimus; Treatment Outcome

2014
TRPA1 and TRPV1 Antagonists Do Not Inhibit Human Acidosis-Induced Pain.
    The journal of pain, 2017, Volume: 18, Issue:5

    Topics: Acid Sensing Ion Channel Blockers; Acidosis; Adult; Amiloride; Analgesics; Analysis of Variance; Capsaicin; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Oximes; Pain; Pain Measurement; Pyrazines; Pyridines; TRPA1 Cation Channel; TRPV Cation Channels

2017
Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma.
    Blood, 2010, Aug-05, Volume: 116, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Combined Modality Therapy; Dexamethasone; Fatigue; Hematologic Diseases; Humans; Lenalidomide; Multiple Myeloma; Pain; Pyrazines; Remission Induction; Sensation Disorders; Stem Cell Transplantation; Survival Analysis; Thalidomide; Treatment Outcome

2010
Substance P-induced skin inflammation is not modulated by a single dose of sitagliptin in human volunteers.
    Biological chemistry, 2011, Volume: 392, Issue:3

    Topics: Capsaicin; Carbonated Beverages; Cross-Over Studies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Double-Blind Method; Drug Eruptions; Edema; Erythema; Humans; Injections, Intradermal; Male; Pain; Pyrazines; Sitagliptin Phosphate; Skin; Substance P; Triazoles; Vasodilation

2011
Dose-finding trial using Oltipraz to treat schoolchildren infected with Schistosoma mansoni in Gezira, Sudan.
    The Journal of tropical medicine and hygiene, 1985, Volume: 88, Issue:2

    Topics: Abdomen; Administration, Oral; Child; Clinical Trials as Topic; Feces; Fingers; Follow-Up Studies; Humans; Pain; Parasite Egg Count; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiones; Thiophenes; Vision Disorders

1985

Other Studies

33 other study(ies) available for pyrazines and Pain

ArticleYear
Functional Characterization of Mechanosensitive Piezo1 Channels in Trigeminal and Somatic Nerves in a Neuron-on-Chip Model.
    International journal of molecular sciences, 2022, Jan-25, Volume: 23, Issue:3

    Topics: Animals; Ganglia, Spinal; Hyperalgesia; Ion Channels; Lab-On-A-Chip Devices; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Nerve Tissue; Neurons; Pain; Peripheral Nervous System; Pyrazines; Thiadiazoles; Touch; Trigeminal Nerve

2022
Treating sickle cell anemia: A new era dawns.
    American journal of hematology, 2020, Volume: 95, Issue:4

    Topics: Anemia, Sickle Cell; Antibodies, Monoclonal, Humanized; Benzaldehydes; Child; Fetal Hemoglobin; Forecasting; Gene Expression Regulation; Genetic Therapy; Hematopoietic Stem Cell Transplantation; Humans; Hydroxyurea; Hypoxia, Brain; Infant; P-Selectin; Pain; Pyrazines; Pyrazoles; Therapies, Investigational

2020
[75/f-increasing pain with knee TEP : Preparation for the medical specialist examination-case 5].
    Der Orthopade, 2021, Volume: 50, Issue:Suppl 1

    Topics: Humans; Knee Joint; Medicine; Pain; Pyrazines; Specialization

2021
HO-CO pathway activation may be associated with hippocampal μ and δ opioid receptors in inhibiting inflammatory pain aversiveness and nociception in WT but not NOS2-KO mice.
    Brain research bulletin, 2021, Volume: 169

    Topics: Animals; Avoidance Learning; Carbon Monoxide; Heme Oxygenase (Decyclizing); Hippocampus; Male; Mice; Mice, Knockout; Nociception; Organometallic Compounds; Pain; Pain Measurement; Pyrazines; Pyrroles; Receptors, Opioid, delta; Receptors, Opioid, mu; Signal Transduction

2021
Ligustrazine Enhances the Hypnotic and Analgesic Effect of Ketamine in Mice.
    Biological & pharmaceutical bulletin, 2018, May-01, Volume: 41, Issue:5

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Hypnotics and Sedatives; Injections, Intraperitoneal; Ketamine; Male; Mice, Inbred C57BL; Pain; Pyrazines

2018
Presynaptic facilitation by tetracaine of glutamatergic spontaneous excitatory transmission in the rat spinal substantia gelatinosa - Involvement of TRPA1 channels.
    Brain research, 2017, 02-15, Volume: 1657

    Topics: Acetanilides; Amides; Anesthetics, Local; Animals; Bupivacaine; Capsaicin; Excitatory Postsynaptic Potentials; Glutamic Acid; Levobupivacaine; Male; Neurotransmitter Agents; Pain; Patch-Clamp Techniques; Presynaptic Terminals; Prilocaine; Purines; Pyrazines; Pyridines; Rats, Sprague-Dawley; Ropivacaine; Ruthenium Red; Substantia Gelatinosa; Tetracaine; Tetrodotoxin; Tissue Culture Techniques; TRPA1 Cation Channel; TRPC Cation Channels

2017
From bench to bedside: a case of rapid reversal of bortezomib-induced neuropathic pain by the TRPM8 activator, menthol.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, Sep-20, Volume: 26, Issue:27

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Boronic Acids; Bortezomib; Dose-Response Relationship, Drug; Female; Humans; Male; Menthol; Middle Aged; Multiple Myeloma; Pain; Peripheral Nervous System Diseases; Protease Inhibitors; Pyrazines; TRPM Cation Channels

2008
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
    Bioorganic & medicinal chemistry letters, 2009, May-01, Volume: 19, Issue:9

    Topics: Acid Sensing Ion Channels; Acidosis; Amiloride; Amines; Animals; Chemistry, Pharmaceutical; Drug Design; Electrophysiology; Inhibitory Concentration 50; Male; Models, Chemical; Nerve Tissue Proteins; Pain; Pyrazines; Rats; Rats, Sprague-Dawley; Sodium Channels

2009
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
    Journal of medicinal chemistry, 2009, May-14, Volume: 52, Issue:9

    Topics: Administration, Oral; Animals; Cell Line; Constriction, Pathologic; Disease Models, Animal; Drug Discovery; Enzyme Inhibitors; Fluoroquinolones; Formaldehyde; Humans; Inhibitory Concentration 50; Lipopolysaccharides; Mice; Nitric Oxide Synthase Type II; Pain; Protein Multimerization; Protein Structure, Quaternary; Pyrazines; Quinolones; Structure-Activity Relationship; Substrate Specificity

2009
Multiple significant bortezomib-related toxicities in one patient: case report and literature review.
    Clinical lymphoma & myeloma, 2009, Volume: 9, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Doxorubicin; Humans; Male; Multiple Myeloma; Pain; Peripheral Nervous System Diseases; Pruritus; Pyrazines; Testis

2009
Bortezomib-induced painful neuropathy in rats: a behavioral, neurophysiological and pathological study in rats.
    European journal of pain (London, England), 2010, Volume: 14, Issue:4

    Topics: Animals; Antineoplastic Agents; Behavior, Animal; Blood Cell Count; Blood Chemical Analysis; Body Weight; Boronic Acids; Bortezomib; Dose-Response Relationship, Drug; Female; Hot Temperature; Neural Conduction; Neurotoxicity Syndromes; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pyrazines; Rats; Rats, Wistar; Sciatic Nerve

2010
Neurophysiological, histological and immunohistochemical characterization of bortezomib-induced neuropathy in mice.
    Experimental neurology, 2010, Volume: 223, Issue:2

    Topics: Action Potentials; Animals; Antineoplastic Agents; Boronic Acids; Bortezomib; Electrophysiology; Female; Ganglia, Spinal; Immunohistochemistry; Mice; Microscopy, Electron; Motor Neurons; Myelin Sheath; Nerve Fibers, Unmyelinated; Neural Conduction; Pain; Peripheral Nervous System Diseases; Protease Inhibitors; Pyrazines; Sciatic Nerve; Sensory Receptor Cells; Skin; Tibial Nerve

2010
Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
    Journal of medicinal chemistry, 2010, Apr-22, Volume: 53, Issue:8

    Topics: Analgesics; Animals; Biological Availability; Capsaicin; Chlorocebus aethiops; COS Cells; Hot Temperature; Humans; Hyperalgesia; In Vitro Techniques; Inflammation; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Pyridines; Pyrimidines; Quinazolines; Quinolines; Rats; Structure-Activity Relationship; TRPV Cation Channels

2010
Effect of transient receptor potential vanilloid 1 (TRPV1) receptor antagonist compounds SB705498, BCTC and AMG9810 in rat models of thermal hyperalgesia measured with an increasing-temperature water bath.
    European journal of pharmacology, 2010, Sep-01, Volume: 641, Issue:2-3

    Topics: Acrylamides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cold Temperature; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Female; Hot Temperature; Hyperalgesia; Pain; Pyrazines; Pyridines; Pyrrolidines; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Urea

2010
Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates.
    Bioorganic & medicinal chemistry, 2010, Jul-15, Volume: 18, Issue:14

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Ear; Edema; Female; Freund's Adjuvant; Hydrazones; Male; Mice; Pain; Peritonitis; Pyrazines; Rats; Rats, Wistar; Zymosan

2010
Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.
    Bioorganic & medicinal chemistry letters, 2010, Aug-01, Volume: 20, Issue:15

    Topics: Administration, Oral; Animals; Dogs; Drug Evaluation, Preclinical; Humans; Hyperalgesia; Macaca mulatta; Microsomes, Liver; Naphthyridines; Pain; Pyrazines; Rats; TRPV Cation Channels

2010
Discovery of dual inducible/neuronal nitric oxide synthase (iNOS/nNOS) inhibitor development candidate 4-((2-cyclobutyl-1H-imidazo[4,5-b]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1H)-one (KD7332) part 2: identification of a novel, potent, and selective
    Journal of medicinal chemistry, 2010, Nov-11, Volume: 53, Issue:21

    Topics: Administration, Oral; Analgesics; Animals; Cell Line; Drug Tolerance; Fluoroquinolones; Humans; In Vitro Techniques; Mice; Microsomes, Liver; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Pain; Pain Measurement; Peripheral Nervous System Diseases; Protein Multimerization; Pyrazines; Rotarod Performance Test; Structure-Activity Relationship

2010
Follow-up psychophysical studies in bortezomib-related chemoneuropathy patients.
    The journal of pain, 2011, Volume: 12, Issue:9

    Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pilot Projects; Pyrazines

2011
Mitotoxicity and bortezomib-induced chronic painful peripheral neuropathy.
    Experimental neurology, 2012, Volume: 238, Issue:2

    Topics: Acetylcarnitine; Activating Transcription Factor 3; Adenosine Triphosphate; Analysis of Variance; Animals; Antineoplastic Agents; Axons; Boronic Acids; Bortezomib; Citrate (si)-Synthase; Disease Models, Animal; Electron Transport Complex II; Ganglia, Spinal; Hyperalgesia; Male; Mitochondria; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System Diseases; Pyrazines; Rats; Rats, Sprague-Dawley; Schwann Cells; Sciatic Nerve; Time Factors; Ubiquitin Thiolesterase

2012
N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: II. in vivo characterization in rat models of inflammatory and neuropath
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 306, Issue:1

    Topics: Analgesics; Animals; Ataxia; Capsaicin; Hyperalgesia; Inflammation; Male; Nerve Tissue; Pain; Pain Threshold; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Drug

2003
Effect of tetramethylpyrazine on acute nociception mediated by signaling of P2X receptor activation in rat.
    Brain research, 2004, Jan-09, Volume: 995, Issue:2

    Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spinal; Hindlimb; Injections, Subcutaneous; Male; Membrane Potentials; Neurons, Afferent; Pain; Purinergic P2 Receptor Agonists; Pyrazines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X

2004
Novel 2',6'-dimethyl-L-tyrosine-containing pyrazinone opioid mimetic mu-agonists with potent antinociceptive activity in mice.
    The Journal of pharmacology and experimental therapeutics, 2004, Volume: 309, Issue:1

    Topics: Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Guinea Pigs; Male; Mice; Molecular Mimicry; Morphine; Pain; Pyrazines; Receptors, Opioid, mu; Tyrosine

2004
Involvement of an increased spinal TRPV1 sensitization through its up-regulation in mechanical allodynia of CCI rats.
    Neuropharmacology, 2005, Volume: 49, Issue:7

    Topics: Animals; Blotting, Western; Calcitonin Gene-Related Peptide; Capsaicin; In Vitro Techniques; Injections, Spinal; Male; Nerve Tissue Proteins; Neuropeptides; Pain; Pain Measurement; Physical Stimulation; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Spinal Cord; Spinal Cord Injuries; Substance P; TRPV Cation Channels; Up-Regulation

2005
Bortezomib-induced Sweet's syndrome.
    Haematologica, 2005, Volume: 90, Issue:12 Suppl

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Drug Administration Schedule; Erectile Dysfunction; Humans; Immunosuppressive Agents; Male; Melphalan; Methylprednisolone; Multiple Myeloma; Pain; Peripheral Nervous System Diseases; Prednisolone; Protease Inhibitors; Pyrazines; Recurrence; Sleep Initiation and Maintenance Disorders; Sweet Syndrome; Testicular Diseases

2005
Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo.
    Biochemical and biophysical research communications, 2006, Nov-10, Volume: 350, Issue:1

    Topics: Animals; Base Sequence; Capsaicin; Chlorocebus aethiops; Colitis; COS Cells; Disease Models, Animal; Humans; Male; Mice; Molecular Sequence Data; Nervous System Diseases; Pain; Pyrazines; Pyridines; Rats; RNA Interference; Sequence Alignment; Sequence Homology, Amino Acid; TRPV Cation Channels

2006
Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.
    Bioorganic & medicinal chemistry letters, 2007, Jan-15, Volume: 17, Issue:2

    Topics: Animals; Binding, Competitive; Chemical Phenomena; Chemistry, Physical; CHO Cells; Chronic Disease; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Glutamic Acid; Pain; Pyrazines; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship

2007
Quantitative sensory findings in patients with bortezomib-induced pain.
    The journal of pain, 2007, Volume: 8, Issue:4

    Topics: Aged; Antineoplastic Agents; Boronic Acids; Bortezomib; Chronic Disease; Cold Temperature; Female; Hot Temperature; Humans; Lymphoma, B-Cell; Male; Middle Aged; Multiple Myeloma; Pain; Pain Measurement; Pain Threshold; Psychomotor Performance; Pyrazines; Sensation; Sensation Disorders; Thermosensing; Touch

2007
Possible involvement of spinal noradrenergic mechanisms in the antiallodynic effect of intrathecally administered 5-HT2C receptor agonists in the rats with peripheral nerve injury.
    European journal of pharmacology, 2007, Jul-12, Volume: 567, Issue:1-2

    Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Atropine; Injections, Spinal; Ligation; Male; Muscarinic Antagonists; Norepinephrine; Pain; Peripheral Nervous System Diseases; Physical Stimulation; Piperazines; Pyrazines; Rats; Rats, Wistar; Serotonin 5-HT2 Receptor Agonists; Spinal Cord; Spinal Nerves; Touch; Yohimbine

2007
Pharmacological characterization of the muscarinic agonist (3R,4R)-3-(3-hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptane (WAY-132983) in in vitro and in vivo models of chronic pain.
    The Journal of pharmacology and experimental therapeutics, 2007, Volume: 322, Issue:3

    Topics: Animals; Biological Availability; Bridged-Ring Compounds; Chronic Disease; Disease Models, Animal; Inflammation; Inhibitory Concentration 50; Muscarinic Agonists; Pain; Pyrazines; Rats; Receptors, Muscarinic

2007
Bortezomib-induced peripheral neurotoxicity: still far from a painless gain.
    Haematologica, 2007, Volume: 92, Issue:10

    Topics: Animals; Boronic Acids; Bortezomib; Humans; Neurotoxicity Syndromes; Pain; Pyrazines

2007
Pharmacologic investigation of the mechanism underlying cold allodynia using a new cold plate procedure in rats with chronic constriction injuries.
    Behavioural pharmacology, 2008, Volume: 19, Issue:1

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Calcium Channel Blockers; Chronic Disease; Cold Temperature; Constriction, Pathologic; Disease Models, Animal; Diterpenes; gamma-Aminobutyric Acid; Male; Mexiletine; Morphine; Nerve Fibers, Unmyelinated; Pain; Pain Measurement; Peripheral Nervous System Diseases; Pregabalin; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Reaction Time; Sciatic Nerve; Sodium Channel Blockers; TRPV Cation Channels

2008
[Clinical study of the anti-inflammatory agent: carudol].
    Revue d'odonto-stomatologie du midi de la France, 1972, Volume: 30, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents; Cellulitis; Edema; Female; Humans; Jaw Fractures; Joint Diseases; Male; Middle Aged; Osteitis; Pain; Postoperative Care; Preoperative Care; Prognosis; Pyrazines; Surgery, Plastic; Temporomandibular Joint; Tooth Extraction

1972
[Pain from the viewpoint of the general practitioner. Experiences with a new analgesic].
    Medizinische Monatsschrift, 1969, Volume: 23, Issue:8

    Topics: Adolescent; Adult; Aged; Amobarbital; Analgesics; Antipyrine; Caffeine; Family Practice; Humans; Middle Aged; Pain; Phenazines; Pyrazines

1969