| Assay ID | Title | Year | Journal | Article |
|---|
| AID657055 | Selectivity ratio of Ki for mouse delta opioid receptor to Ki for guinea pig kappa opioid receptor | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain. |
| AID673191 | Displacement of [3H]DAMGO from mu opioid receptor in mouse cerebellum | 2012 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 22, Issue:15
| Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies. |
| AID389665 | Antinociceptive activity in sc dosed mouse assessed as inhibition of acetic acid-induced writhing administered 15 mins before acetic acid challenge | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID724711 | Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells after 2 hrs by [35S]-GTPgammaS binding assay relative to control | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives. |
| AID1245662 | Therapeutic index, ratio of ED50 for induction of sedation in ICR mouse by spontaneous locomotor activity test to ED50 for antinociceptive activity in ICR mouse by acetic acid abdominal constriction test | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain. |
| AID389682 | Selectivity ratio of Ke for mu opioid receptor in guinea pig ileum to Ke for kappa opioid receptor in guinea pig ileum | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID1487646 | Agonist activity at kappa opioid receptor (unknown origin) | 2017 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16
| Discovery of highly selective κ-opioid receptor agonists: 10α-Hydroxy TRK-820 derivatives. |
| AID603727 | Selectivity ratio of Ki for delta opioid receptor in guinea pig forebrain homogenate to Ki for kappa opioid receptor in guinea pig cerebellum homogenate | 2011 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 21, Issue:13
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1. |
| AID657054 | Selectivity ratio of Ki for mouse mu opioid receptor to Ki for guinea pig kappa opioid receptor | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain. |
| AID718963 | Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig cerebellum membranes | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies. |
| AID718965 | Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain membranes without cerebellum | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies. |
| AID1426493 | Antagonist activity at human OX1R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15 mins followed by orexin A addition by Fura-2-AM dye based fluorescence assay | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. |
| AID603730 | Displacement of [3H]DAMGO from mu opioid receptor in guinea pig forebrain homogenate by scintillation counting | 2011 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 21, Issue:13
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1. |
| AID718962 | Selectivity ratio of Ki for mu opioid receptor in mouse whole brain membranes without cerebellum to Ki for kappa opioid receptor in guinea pig cerebellum membranes | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies. |
| AID389663 | Equilibrium constant, ratio of IC50 for kappa opioid receptor in ddy mouse vas deferens in presence of 10 nM nor-BNI to IC50 for kappa opioid receptor in ddy mouse vas deferens | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID389661 | Equilibrium constant, ratio of IC50 for delta opioid receptor in ddy mouse vas deferens in presence of 10 nM Naltrindole to IC50 for delta opioid receptor in ddy mouse vas deferens | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID389673 | Equilibrium constant, ratio of IC50 for mu opioid receptor in guinea pig ileum in presence of 100 nM Naloxone to IC50 for mu opioid receptor in guinea pig ileum | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID724714 | Selectivity ratio of Ki for mu opioid receptor in mouse whole brain membranes without cerebellum to Ki for kappa opioid receptor in guinea pig cerebellum | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives. |
| AID1245656 | Selectivity index, ratio of Ki for MOR in guinea pig cerebellum membranes to Ki for KOR in mouse whole brain membranes without cerebellum | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain. |
| AID1426494 | Antagonist activity at human OX2R expressed in CHOK1 cells assessed as inhibition of orexin A-induced intracellular calcium level preincubated for 15 mins followed by orexin A addition by Fura-2-AM dye based fluorescence assay | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. |
| AID1245661 | Induction of sedation in ICR mouse by spontaneous locomotor activity test | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain. |
| AID1426492 | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting method | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. |
| AID1426497 | Solubility of the compound in water | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. |
| AID389656 | Antinociceptive activity in sc dosed kappa opioid receptor antagonist nor-BNI treated mouse assessed as inhibition of acetic acid-induced writhing administered 15 mins before acetic acid challenge | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID718961 | Selectivity ratio of Ki for delta opioid receptor in mouse whole brain membranes without cerebellum to Ki for kappa opioid receptor in guinea pig cerebellum membranes | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies. |
| AID1245653 | Displacement of [3H]DAMGO from MOR in guinea pig cerebellum membranes | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain. |
| AID1426498 | Solubility of the compound in saline | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. |
| AID1245657 | Selectivity index, ratio of Ki for DOR in mouse whole brain membranes without cerebellum to Ki for KOR in mouse whole brain membranes without cerebellum | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain. |
| AID657052 | Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain without cerebellum | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain. |
| AID389667 | Antinociceptive activity in po dosed mouse assessed as inhibition of acetic acid-induced writhing administered 15 mins before acetic acid challenge | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID1245654 | Displacement of [3H]DPDPE from DOR in mouse whole brain membranes without cerebellum | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain. |
| AID724712 | Agonist activity at human recombinant kappa opioid receptor expressed in CHO cells after 2 hrs by [35S]-GTPgammaS binding assay | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives. |
| AID1426499 | Selectivity index, ratio of IC50 for human OX2R expressed in CHOK1 cells to IC50 for human OX1R expressed in CHOK1 cells | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. |
| AID724716 | Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain membranes without cerebellum after 1 hr by liquid scintillation counting analysis | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives. |
| AID389671 | Equilibrium constant, ratio of IC50 for kappa opioid receptor in guinea pig ileum in presence of 10 nM nor-BNI to IC50 for kappa opioid receptor in guinea pig ileum | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID1487647 | Agonist activity at mu opioid receptor (unknown origin) | 2017 | Bioorganic & medicinal chemistry letters, 08-15, Volume: 27, Issue:16
| Discovery of highly selective κ-opioid receptor agonists: 10α-Hydroxy TRK-820 derivatives. |
| AID389678 | Selectivity ratio of Ke for mu opioid receptor in ddy mouse vas deferens to Ke for kappa opioid receptor in ddy mouse vas deferens | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID724713 | Selectivity ratio of Ki for delta opioid receptor in mouse whole brain membranes without cerebellum to Ki for kappa opioid receptor in guinea pig cerebellum | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives. |
| AID1426495 | Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting method | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. |
| AID673193 | Displacement of [3H]U-69,593 from kappa opioid receptor in guinea pig cerebellum | 2012 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 22, Issue:15
| Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies. |
| AID1245655 | Displacement of [3H]U69,593 from KOR in mouse whole brain membranes without cerebellum | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain. |
| AID389660 | Equilibrium constant, ratio of IC50 for mu opioid receptor in ddy mouse vas deferens in presence of 100 nM naloxone to IC50 for mu opioid receptor in ddy mouse vas deferens | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID603729 | Displacement of [3H]NTI from delta opioid receptor in guinea pig forebrain homogenate by scintillation counting | 2011 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 21, Issue:13
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1. |
| AID724715 | Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellum after 1 hr by liquid scintillation counting analysis | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives. |
| AID603728 | Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellum homogenate by scintillation counting | 2011 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 21, Issue:13
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1. |
| AID603731 | Selectivity ratio of Ki for mu opioid receptor in guinea pig forebrain homogenate to Ki for kappa opioid receptor in guinea pig cerebellum homogenate | 2011 | Bioorganic & medicinal chemistry letters, Jul-01, Volume: 21, Issue:13
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1. |
| AID657051 | Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain without cerebellum | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain. |
| AID657053 | Displacement of [3H]U69593 from kappa opioid receptor in guinea pig cerebellum | 2012 | Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain. |
| AID389681 | Antinociceptive activity in sc dosed mu opioid receptor antagonist naloxone treated mouse assessed as inhibition of acetic acid-induced writhing administered 15 mins before acetic acid challenge | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID1426496 | Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cell membranes by micro-beta scintillation counting method | 2017 | Journal of medicinal chemistry, 02-09, Volume: 60, Issue:3
| Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. |
| AID673192 | Displacement of [3H]DPDPE from delta opioid receptor in mouse cerebellum | 2012 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 22, Issue:15
| Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies. |
| AID1245660 | Antinociceptive activity in ICR mouse assessed as reduction in acetic acid-induced abdominal writhing dosed subcutaneously 15 mins before acetic acid challenge | 2015 | Bioorganic & medicinal chemistry, Oct-01, Volume: 23, Issue:19
| Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain. |
| AID724717 | Displacement of [3H]DAMGO from mu opioid receptor in mouse whole brain membranes without cerebellum after 1 hr by liquid scintillation counting analysis | 2013 | Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
| The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives. |
| AID718964 | Displacement of [3H]DPDPE from delta opioid receptor in mouse whole brain membranes without cerebellum | 2012 | Bioorganic & medicinal chemistry letters, Dec-15, Volume: 22, Issue:24
| Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies. |
| AID389680 | Antinociceptive activity in sc dosed delta opioid receptor antagonist Naloxone treated mouse assessed as inhibition of acetic acid-induced writhing administered 15 mins before acetic acid challenge | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID389669 | Inhibition of acetic acid-induced writhing in sc dosed mouse up to 180 mins administered 15 mins before acetic acid challenge | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID389668 | Ratio of ED50 for acetic acid-induced writhing in po dosed mouse to ED50 for acetic acid-induced writhing in sc dosed mouse | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID389657 | Agonist activity at kappa opioid receptor in ddy mouse vas deferens assessed as inhibition of electric stimulation-induced contraction | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID389655 | Antinociceptive activity in po dosed mouse by tail flick test | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID673195 | Selectivity ratio of Ki for delta opioid receptor in mouse cerebellum to Ki for kappa opioid receptor in guinea pig cerebellum | 2012 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 22, Issue:15
| Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies. |
| AID389659 | Equilibrium constant, ratio of IC50 for mu opioid receptor in ddy mouse vas deferens in presence of 30 nM naloxone to IC50 for mu opioid receptor in ddy mouse vas deferens | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID389670 | Agonist activity at kappa opioid receptor in guinea pig ileum assessed as inhibition of electric stimulation-induced contraction | 2008 | Bioorganic & medicinal chemistry, Oct-15, Volume: 16, Issue:20
| Design, synthesis, and structure-activity relationship of novel opioid kappa-agonists. |
| AID673194 | Selectivity ratio of Ki for mu opioid receptor in mouse cerebellum to Ki for kappa opioid receptor in guinea pig cerebellum | 2012 | Bioorganic & medicinal chemistry letters, Aug-01, Volume: 22, Issue:15
| Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |