phenobarbital has been researched along with Pain in 37 studies
Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A randomized, double-blind controlled trial is reported comparing phenobarbital and clonazepam for the purpose of sedative-hypnotic taper in inpatients with chronic, nonmalignant pain." | 9.07 | Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study. ( Lynn, P; Roy-Byrne, P; Sullivan, M; Toshima, M, 1993) |
| "The purpose of this investigation was to determine the effects of adrenalectomy and adrenalectomy with corticosterone replacement on pain sensitivity and on the pharmacodynamics of a central nervous system depressant, phenobarbital, and a central nervous system stimulant, theophylline." | 7.68 | Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats. ( Hoffman, A; Levy, G, 1993) |
| "Deafferentation pain has been related to abnormal electrical hyperactivity in the neurons of the sensory relays in the central nervous system." | 5.28 | Antinociceptive effects of phenobarbital in "tail-flick" test and deafferentation pain. ( González-Darder, JM; Ortega-Alvaro, A; Ruz-Franzi, I; Segura-Pastor, D, 1992) |
| "A randomized, double-blind controlled trial is reported comparing phenobarbital and clonazepam for the purpose of sedative-hypnotic taper in inpatients with chronic, nonmalignant pain." | 5.07 | Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study. ( Lynn, P; Roy-Byrne, P; Sullivan, M; Toshima, M, 1993) |
| "The antinociceptive effect of MCO was evaluated using several experimental pain models, including thermal nociception methods, such as the tail immersion and the hotplate tests, as well as chemical nociception induced by intraperitoneal acetic acid and subplantar formalin administration in mice." | 3.77 | Antinociceptive and hypnotic properties of Celastrus orbiculatus. ( Cha, DS; Jeon, H; Park, HJ, 2011) |
| "The purpose of this investigation was to determine the effects of adrenalectomy and adrenalectomy with corticosterone replacement on pain sensitivity and on the pharmacodynamics of a central nervous system depressant, phenobarbital, and a central nervous system stimulant, theophylline." | 3.68 | Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats. ( Hoffman, A; Levy, G, 1993) |
| "Heart rate, cardiac output, mean arterial blood pressure (MABP), and cerebral blood flow (CBF) were measured in 12 newborn piglets (6 controls and 6 pretreated with 20 mg/kg phenobarbital), under two different stresses: pain stimulation and intravenous injection of 2." | 3.67 | Effect of phenobarbital on cerebral blood flow in the newborn piglet under stress. ( Aranda, JV; Beharry, K; Chemtob, S; Laudignon, N; Rex, J, 1986) |
| " Pharmacokinetic parameters of nicorandil and its isomers, as well as the plasma concentrations of the corresponding denitrated metabolites and also nicotinamide and nitrite were determined." | 1.40 | Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers. ( Almeida, MO; Araujo, DP; César, IC; Coelho, MM; de Fátima, A; Dutra, MM; Godin, AM; Machado, RR; Menezes, RR; Oliveira, FC; Pianetti, GA; Santos, DA; Santos, JR, 2014) |
| "Deafferentation pain has been related to abnormal electrical hyperactivity in the neurons of the sensory relays in the central nervous system." | 1.28 | Antinociceptive effects of phenobarbital in "tail-flick" test and deafferentation pain. ( González-Darder, JM; Ortega-Alvaro, A; Ruz-Franzi, I; Segura-Pastor, D, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (62.16) | 18.7374 |
| 1990's | 5 (13.51) | 18.2507 |
| 2000's | 3 (8.11) | 29.6817 |
| 2010's | 5 (13.51) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Salomé, C | 1 |
| Salomé-Grosjean, E | 1 |
| Stables, JP | 1 |
| Kohn, H | 1 |
| César, IC | 1 |
| Godin, AM | 1 |
| Araujo, DP | 1 |
| Oliveira, FC | 1 |
| Menezes, RR | 1 |
| Santos, JR | 1 |
| Almeida, MO | 1 |
| Dutra, MM | 1 |
| Santos, DA | 1 |
| Machado, RR | 1 |
| Pianetti, GA | 1 |
| Coelho, MM | 1 |
| de Fátima, A | 1 |
| Stróżyk, A | 1 |
| Paraskevas, T | 1 |
| Romantsik, O | 1 |
| Calevo, MG | 1 |
| Banzi, R | 1 |
| Ley, D | 1 |
| Bruschettini, M | 1 |
| Patel, C | 1 |
| Kleinig, P | 1 |
| Bakker, M | 1 |
| Tait, P | 1 |
| Braun, B | 1 |
| Reber, M | 1 |
| Park, HJ | 1 |
| Cha, DS | 1 |
| Jeon, H | 1 |
| KRAUSE, HJ | 2 |
| STOLL, P | 1 |
| KRUGER, EH | 1 |
| FROMMEL, E | 2 |
| FLEURY, C | 1 |
| LEDEBUR, IV | 1 |
| BEGUIN, M | 1 |
| FAMILY, S | 1 |
| Dodman, NH | 1 |
| Billingham, EA | 1 |
| Moon-Fanelli, AA | 1 |
| Savica, R | 1 |
| Beghi, E | 1 |
| Mazzaglia, G | 1 |
| Innocenti, F | 1 |
| Brignoli, O | 1 |
| Cricelli, C | 1 |
| Caputi, AP | 1 |
| Musolino, R | 1 |
| Spina, E | 1 |
| Trifirò, G | 1 |
| Perlík, F | 1 |
| Doi, T | 1 |
| Jurna, I | 1 |
| Goldman, SI | 1 |
| Krings, MS | 1 |
| Sullivan, M | 1 |
| Toshima, M | 1 |
| Lynn, P | 1 |
| Roy-Byrne, P | 1 |
| Hoffman, A | 1 |
| Levy, G | 1 |
| Salvolini, U | 1 |
| Bonetti, MG | 1 |
| Ciritella, P | 1 |
| Rovetta, G | 1 |
| Baratto, L | 1 |
| Farinelli, G | 1 |
| Monteforte, P | 1 |
| González-Darder, JM | 1 |
| Ortega-Alvaro, A | 1 |
| Ruz-Franzi, I | 1 |
| Segura-Pastor, D | 1 |
| Buckley, PF | 1 |
| Sizemore, WA | 1 |
| Charlton, EJ | 1 |
| Laudignon, N | 1 |
| Chemtob, S | 1 |
| Beharry, K | 1 |
| Rex, J | 1 |
| Aranda, JV | 1 |
| Flügel, KA | 1 |
| Moggian, G | 2 |
| Cervellati, I | 2 |
| Tamburini, E | 2 |
| Riethe, P | 1 |
| Wilske, E | 1 |
| Christiansen, J | 1 |
| Dam, M | 1 |
| Haase, J | 1 |
| Jepsen, BV | 1 |
| Bech, H | 1 |
| Langeback, E | 1 |
| Puri, SK | 1 |
| Lal, H | 1 |
| Hunter, J | 1 |
| Thompson, RP | 1 |
| Rake, MO | 1 |
| Williams, R | 1 |
| Filipescu, A | 1 |
| Spirescu, J | 1 |
| Seydoux, J | 1 |
| von Ledebur, I | 1 |
| Chmouliovsky, M | 1 |
| Prasad, CR | 1 |
| Schnell, U | 1 |
| Solc, J | 1 |
| Sauerová, Z | 1 |
| Qaqundah, BY | 1 |
| Taylor, WF | 1 |
| Klittscher, K | 1 |
| Paalzow, L | 1 |
2 reviews available for phenobarbital and Pain
| Article | Year |
|---|---|
Pharmacological pain and sedation interventions for the prevention of intraventricular hemorrhage in preterm infants on assisted ventilation - an overview of systematic reviews.
Topics: Acetaminophen; Analgesics, Opioid; Cerebral Hemorrhage; Female; Heroin; Humans; Ibuprofen; Infant, N | 2023 |
Palliative sedation: A safety net for the relief of refractory and intolerable symptoms at the end of life.
Topics: Aged; Analgesics; Conscious Sedation; Dehydration; Dyspnea; Humans; Hydromorphone; Hypnotics and Sed | 2019 |
6 trials available for phenobarbital and Pain
| Article | Year |
|---|---|
[Clinical evaluation of analgesics].
Topics: Adult; Aged; Analgesics; Antipyrine; Aspirin; Caffeine; Clinical Trials as Topic; Codeine; Drug Comb | 1984 |
Phenobarbital versus clonazepam for sedative-hypnotic taper in chronic pain patients. A pilot study.
Topics: Adult; Anxiety Disorders; Chronic Disease; Clonazepam; Double-Blind Method; Female; Hospitalization; | 1993 |
[Critical study of the post-partum pain by means of a clinical pharmacology experiment].
Topics: Adult; Aspirin; Clinical Trials as Topic; Female; Humans; Methylphenidate; Pain; Phenobarbital; Plac | 1972 |
[Comparative study of a psychostimulating drug in the treatment of post-partum pain].
Topics: Adult; Analgesics; Aspirin; Clinical Trials as Topic; Female; Humans; Methylphenidate; Pain; Phenoba | 1973 |
[Analgetic effects on the stimulus threshold of the human tooth].
Topics: Administration, Oral; Amides; Analgesics; Analysis of Variance; Aspirin; Caffeine; Clinical Trials a | 1974 |
Controlled trial of phetharbital, a non-hypnotic barbiturate, in unconugated hyperbilirubinaemia.
Topics: Abdomen; Barbiturates; Bilirubin; Clinical Trials as Topic; Female; Humans; Hyperbilirubinemia, Here | 1971 |
29 other studies available for phenobarbital and Pain
| Article | Year |
|---|---|
Merging the structural motifs of functionalized amino acids and alpha-aminoamides: compounds with significant anticonvulsant activities.
Topics: Acetamides; Alanine; Amides; Amino Acids; Animals; Anticonvulsants; Benzylamines; Drug Evaluation, P | 2010 |
Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Half-Life; Isomerism; Mice; Nicorandil; Pain | 2014 |
[Pain perception and pain therapy in premature infants].
Topics: Acetaminophen; Age Factors; Analgesics, Non-Narcotic; Analgesics, Opioid; Fentanyl; Humans; Infant; | 2010 |
Antinociceptive and hypnotic properties of Celastrus orbiculatus.
Topics: Acetic Acid; Animals; Celastrus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; F | 2011 |
[Lowering of pain and shortening of the birth process with causat].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Female; Humans; Labor, Obstetric; Niacin; | 1956 |
[Lowering of pain and shortening of the birth process with causat].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Female; Humans; Labor, Obstetric; Niacin; | 1956 |
[Lowering of pain and shortening of the birth process with causat].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Female; Humans; Labor, Obstetric; Niacin; | 1956 |
[Lowering of pain and shortening of the birth process with causat].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Female; Humans; Labor, Obstetric; Niacin; | 1956 |
[The treatment of painful conditions in the true pelvis of the female with ichthobellol compositum].
Topics: Aminopyrine; Belladonna Alkaloids; Disease; Female; Humans; Lesser Pelvis; Pain; Papaverine; Pelvis; | 1957 |
[Labor relief in obstetrical practice].
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Atropine; Humans; Niacin; Nicotinic Acids; Pain; Pa | 1958 |
THE PLACE OF ACETYLSALICYLIC ACID IN PSYCHOPHARMACOLOGY. AN EXPERIMENTAL STUDY.
Topics: Amphetamine; Amphetamines; Animals; Aspirin; Body Temperature Regulation; Chlordiazepoxide; Chlorpro | 1963 |
Animal behavior case of the month. Behavioral seizures.
Topics: Aggression; Analgesics, Opioid; Animals; Anticonvulsants; Behavior, Animal; Butorphanol; Cat Disease | 2005 |
Prescribing patterns of antiepileptic drugs in Italy: a nationwide population-based study in the years 2000-2005.
Topics: Adolescent; Adult; Age Distribution; Aged; Amines; Anticonvulsants; Carbamazepine; Catchment Area, H | 2007 |
Intrathecal pentobarbital prevents naloxone-induced facilitation of the tail-flick response in the rat.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Naloxone; Pain; Phenobarbital; | 1982 |
Phenobarbital-induced fibromyalgia as the cause of bilateral shoulder pain.
Topics: Chronic Disease; Female; Fibromyalgia; Humans; Middle Aged; Pain; Phenobarbital; Shoulder Joint | 1995 |
Kinetics of drug action in disease states. XLI. Effect of adrenalectomy on the hypnotic activity of phenobarbital, the neurotoxicity of theophylline and pain sensitivity in rats.
Topics: Adrenalectomy; Animals; Blood Proteins; Corticosterone; Male; Pain; Pain Threshold; Phenobarbital; R | 1993 |
Accidental intrathecal injection of ionic water-soluble contrast medium: report of a case, including treatment.
Topics: Aged; Analgesia, Epidural; Bone Neoplasms; Consciousness Disorders; Contrast Media; Critical Care; D | 1996 |
Three-month follow-up of shoulder-hand syndrome induced by phenobarbital and treated with gabapentin.
Topics: Acetaminophen; Acetates; Amines; Analgesics; Anticonvulsants; Arthralgia; Cyclohexanecarboxylic Acid | 2001 |
Antinociceptive effects of phenobarbital in "tail-flick" test and deafferentation pain.
Topics: Afferent Pathways; Animals; Behavior, Animal; Male; Pain; Phenobarbital; Rats; Rats, Inbred Strains; | 1992 |
Medication management in patients with chronic non-malignant pain. A review of the use of a drug withdrawal protocol.
Topics: Analgesics, Opioid; Chronic Disease; Drug Combinations; Humans; Hypnotics and Sedatives; Methadone; | 1986 |
Effect of phenobarbital on cerebral blood flow in the newborn piglet under stress.
Topics: Animals; Animals, Newborn; Blood Pressure; Cardiac Output; Cerebrovascular Circulation; Heart Rate; | 1986 |
[Treatment of acute emotional disturbances].
Topics: Alcohol Withdrawal Delirium; Chlormethiazole; Chlorpromazine; Chlorprothixene; Diazepam; Family Char | 1974 |
Influence of phenobarbital and diphenylhydantoin on plasma carbamazepine levels in patients with epilepsy.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Depression, Chemical; Drug Therapy, Combination; Epil | 1973 |
Spinal fracture following radiculography using meglumine iothalamate (Conray).
Topics: Adipates; Adult; Contrast Media; Diazepam; Female; Fractures, Bone; Humans; Hypesthesia; Iothalamic | 1973 |
Reduced threshold to pain induced aggression specifically related to morphine dependence.
Topics: Aggression; Animals; Dextroamphetamine; Drug Synergism; Electroshock; Ethanol; Humans; Male; Morphin | 1974 |
[The pain syndrome of the edentulous alveolar crest and its treatment].
Topics: Administration, Topical; Alveolar Process; Aminopyrine; Anti-Inflammatory Agents; Aspirin; Caffeine; | 1969 |
Neuropharmacological study of central reactions to intense muscular exertion, sensorial fatigue, sexual excitation, hunger, and thirst.
Topics: Amphetamine; Animals; Brain; Electric Stimulation; Electroshock; Fatigue; Female; Guinea Pigs; Hunge | 1966 |
[Dolo-Eupaco as an analgesic in gynecology].
Topics: Adult; Aminopyrine; Analgesics; Benzilates; Codeine; Esters; Female; Genital Diseases, Female; Genit | 1970 |
[Reserpine therapy of periodic vomiting and abdominal pain in children].
Topics: Abdomen; Age Factors; Child; Humans; Pain; Phenobarbital; Reserpine; Vomiting | 1970 |
Recurrent right middle lobe syndrome in an asthmatic child. Case report and serial vectorcardiographic study.
Topics: Asthma; Child; Cough; Ephedrine; Female; Humans; Middle Lobe Syndrome; Pain; Phenobarbital; Predniso | 1970 |
[Control of pain with target therapy with "Spasmo-Dolviran"].
Topics: Analgesics; Aspirin; Codeine; Female; Headache; Humans; Menopause; Neuralgia; Pain; Phenacetin; Phen | 1967 |
Studies of analgesic and anticonvulsant activity in mice by high-frequency electrical stimulation.
Topics: Age Factors; Analgesics; Animals; Anticonvulsants; Aspirin; Body Weight; Electric Stimulation; Elect | 1969 |