Palmitoyltransferase ZDHHC2

A palmitoyltransferase ZDHHC2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UIJ5]

Synonyms

EC 2.3.1.225;
Acyltransferase ZDHHC2;
2.3.1.-;
Reduced expression associated with metastasis protein;
Ream;
Reduced expression in cancer protein;
Rec;
Zinc finger DHHC domain-containing protein 2;
DHHC-2;
Zinc finger p

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (100.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-bromopalmitate	Homo sapiens (human)	IC50	2.0200	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
palmitoyltransferase activity	molecular function	Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. [GOC:ai]
protein-cysteine S-myristoyltransferase activity	molecular function	Catalysis of the transfer of a myristoyl (systematic name, tetradecanoyl) group to a sulfur atom on a cysteine residue of a protein molecule in the reaction: tetradecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-tetradecanoyl-L-cysteinyl-[protein]. [GOC:ai, PMID:22247542, RHEA:59736]
protein-cysteine S-palmitoyltransferase activity	molecular function	Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]. [GOC:ai, GOC:pr, RHEA:36683]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]
protein-cysteine S-stearoyltransferase activity	molecular function	Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein]. [PMID:12681491, PMID:22247542, PMID:22968831, RHEA:59740]

Located In

This protein is located in 9 target(s):

Target	Category	Definition
Golgi membrane	cellular component	The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
postsynaptic density	cellular component	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
recycling endosome membrane	cellular component	The lipid bilayer surrounding a recycling endosome. [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101]
postsynaptic recycling endosome	cellular component	A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation. [PMID:20820847]
postsynaptic recycling endosome membrane	cellular component	The lipid bilayer surrounding a postsynaptic recycling endosome. [GOC:pz]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
postsynaptic recycling endosome	cellular component	A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation. [PMID:20820847]
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]

Involved In

This protein is involved in 15 target(s):

Target	Category	Definition
synapse assembly	biological process	The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). [GOC:mah]
peptidyl-L-cysteine S-palmitoylation	biological process	The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine. [RESID:AA0106]
protein palmitoylation	biological process	The covalent attachment of a palmitoyl group to a protein. [GOC:jl, PMID:15520806]
protein metabolic process	biological process	The chemical reactions and pathways involving a protein. Includes protein modification. [GOC:ma]
regulation of cell-cell adhesion	biological process	Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. [GOC:isa_complete]
regulation of protein catabolic process	biological process	Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators, GOC:jl]
regulation of neuronal synaptic plasticity	biological process	A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:jid, PMID:11891290]
protein localization to plasma membrane	biological process	A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. [GOC:mah]
positive regulation of long-term synaptic potentiation	biological process	Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie]
protein localization to membrane raft	biological process	A process in which a protein is transported to, or maintained in, a location within a membrane raft. [GO_REF:0000087, GOC:dl, GOC:TermGenie, PMID:19414744]
regulation of protein localization to plasma membrane	biological process	Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640]
protein localization to postsynaptic membrane	biological process	A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:9753322]
positive regulation of AMPA glutamate receptor clustering	biological process	Any process that activates or increases the frequency, rate or extent of AMPA glutamate receptor clustering. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424]
positive regulation of endosome to plasma membrane protein transport	biological process	Any process that activates or increases the frequency, rate or extent of endosome to plasma membrane protein transport. [GO_REF:0000058, GOC:TermGenie, PMID:22869721]
protein targeting to membrane	biological process	The process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:curators]

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