A palmitoyltransferase ZDHHC2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9UIJ5]
EC 2.3.1.225;
Acyltransferase ZDHHC2;
2.3.1.-;
Reduced expression associated with metastasis protein;
Ream;
Reduced expression in cancer protein;
Rec;
Zinc finger DHHC domain-containing protein 2;
DHHC-2;
Zinc finger p
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2-bromopalmitate | Homo sapiens (human) | IC50 | 2.0200 | 1 | 1 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| palmitoyltransferase activity | molecular function | Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule. [GOC:ai] |
| protein-cysteine S-myristoyltransferase activity | molecular function | Catalysis of the transfer of a myristoyl (systematic name, tetradecanoyl) group to a sulfur atom on a cysteine residue of a protein molecule in the reaction: tetradecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-tetradecanoyl-L-cysteinyl-[protein]. [GOC:ai, PMID:22247542, RHEA:59736] |
| protein-cysteine S-palmitoyltransferase activity | molecular function | Catalysis of the transfer of a palmitoyl (systematic name, hexadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]. [GOC:ai, GOC:pr, RHEA:36683] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| protein-cysteine S-stearoyltransferase activity | molecular function | Catalysis of the transfer of a stearoyl (systematic name, octadecanoyl) group to a sulfur atom on the cysteine of a protein molecule, in the reaction: octadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-octadecanoyl-L-cysteinyl-[protein]. [PMID:12681491, PMID:22247542, PMID:22968831, RHEA:59740] |
This protein is located in 9 target(s):
| Target | Category | Definition |
|---|---|---|
| Golgi membrane | cellular component | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| postsynaptic density | cellular component | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density] |
| recycling endosome membrane | cellular component | The lipid bilayer surrounding a recycling endosome. [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101] |
| postsynaptic recycling endosome | cellular component | A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation. [PMID:20820847] |
| postsynaptic recycling endosome membrane | cellular component | The lipid bilayer surrounding a postsynaptic recycling endosome. [GOC:pz] |
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| postsynaptic recycling endosome | cellular component | A recycling endosome of the postsynapse. In postsynaptic terminals with dendritic spines, it is typically located at the base of a dendritic spine. It is involved in recycling of neurotransmitter receptors to the postsynaptic membrane. In some cases at least, this recycling is activated by postsynaptic signaling and so can play a role in long term potentiation. [PMID:20820847] |
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
This protein is involved in 15 target(s):
| Target | Category | Definition |
|---|---|---|
| synapse assembly | biological process | The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). [GOC:mah] |
| peptidyl-L-cysteine S-palmitoylation | biological process | The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine. [RESID:AA0106] |
| protein palmitoylation | biological process | The covalent attachment of a palmitoyl group to a protein. [GOC:jl, PMID:15520806] |
| protein metabolic process | biological process | The chemical reactions and pathways involving a protein. Includes protein modification. [GOC:ma] |
| regulation of cell-cell adhesion | biological process | Any process that modulates the frequency, rate or extent of attachment of a cell to another cell. [GOC:isa_complete] |
| regulation of protein catabolic process | biological process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. [GOC:go_curators, GOC:jl] |
| regulation of neuronal synaptic plasticity | biological process | A process that modulates neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers. [GOC:jid, PMID:11891290] |
| protein localization to plasma membrane | biological process | A process in which a protein is transported to, or maintained in, a specific location in the plasma membrane. [GOC:mah] |
| positive regulation of long-term synaptic potentiation | biological process | Any process that activates or increases the frequency, rate or extent of long-term synaptic potentiation. [GOC:BHF, GOC:TermGenie] |
| protein localization to membrane raft | biological process | A process in which a protein is transported to, or maintained in, a location within a membrane raft. [GO_REF:0000087, GOC:dl, GOC:TermGenie, PMID:19414744] |
| regulation of protein localization to plasma membrane | biological process | Any process that modulates the frequency, rate or extent of protein localization to plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11602640] |
| protein localization to postsynaptic membrane | biological process | A process in which a protein is transported to, or maintained in, a location within a postsynaptic membrane. [GO_REF:0000087, GOC:kmv, GOC:TermGenie, PMID:9753322] |
| positive regulation of AMPA glutamate receptor clustering | biological process | Any process that activates or increases the frequency, rate or extent of AMPA glutamate receptor clustering. [GO_REF:0000058, GOC:hjd, GOC:TermGenie, PMID:21558424] |
| positive regulation of endosome to plasma membrane protein transport | biological process | Any process that activates or increases the frequency, rate or extent of endosome to plasma membrane protein transport. [GO_REF:0000058, GOC:TermGenie, PMID:22869721] |
| protein targeting to membrane | biological process | The process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:curators] |