Page last updated: 2024-11-02

pd 98059 and Pain

pd 98059 has been researched along with Pain in 12 studies

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Pulpitis was confirmed by hematoxylin-eosin staining."1.51Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain. ( Jiang, W; Ni, L; Sun, J; Sun, S; Wang, W, 2019)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (41.67)29.6817
2010's7 (58.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Yoon, SY1
Kwon, SG1
Kim, YH1
Yeo, JH1
Ko, HG1
Roh, DH1
Kaang, BK1
Beitz, AJ1
Lee, JH1
Oh, SB1
Sun, S1
Sun, J1
Jiang, W1
Wang, W1
Ni, L1
van den Heuvel, I1
Reichl, S1
Segelcke, D1
Zahn, PK1
Pogatzki-Zahn, EM1
Nakaya, Y1
Tsuboi, Y1
Okada-Ogawa, A1
Shinoda, M2
Kubo, A1
Chen, JY1
Noma, N1
Batbold, D1
Imamura, Y1
Sessle, BJ1
Iwata, K2
Seo, YJ1
Kwon, MS1
Choi, HW1
Choi, SM1
Kim, YW1
Lee, JK1
Park, SH1
Jung, JS1
Suh, HW1
Chen, HS1
He, X1
Qu, F1
Kang, SM1
Yu, Y1
Liao, D1
Lu, SJ1
Lee, Y1
Pai, M1
Brederson, JD1
Wilcox, D1
Hsieh, G1
Jarvis, MF1
Bitner, RS1
Pavao-de-Souza, GF1
Zarpelon, AC1
Tedeschi, GC1
Mizokami, SS1
Sanson, JS1
Cunha, TM1
Ferreira, SH1
Cunha, FQ1
Casagrande, R1
Verri, WA1
Liu, MG1
Matsuura, S1
Honda, K1
Suzuki, I1
Shibuta, K1
Tamagawa, T1
Katagiri, A1
Kiyomoto, M1
Ohara, K1
Furukawa, A1
Urata, K1
Lim, G1
Sung, B1
Ji, RR1
Mao, J1
Hu, HJ1
Carrasquillo, Y1
Karim, F1
Jung, WE1
Nerbonne, JM1
Schwarz, TL1
Gereau, RW1
Ma, W1
Zheng, WH1
Powell, K1
Jhamandas, K1
Quirion, R1

Other Studies

12 other studies available for pd 98059 and Pain

ArticleYear
A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity.
    Molecular pain, 2017, Volume: 13

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Excitatory Amino Acid Agon

2017
Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain.
    BioMed research international, 2019, Volume: 2019

    Topics: Animals; Dental Pulp Cavity; Disease Models, Animal; Flavonoids; Gene Expression Regulation; Inflamm

2019
Selective prevention of mechanical hyperalgesia after incision by spinal ERK1/2 inhibition.
    European journal of pain (London, England), 2015, Volume: 19, Issue:2

    Topics: Animals; Flavonoids; Hyperalgesia; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kina

2015
ERK-GluR1 phosphorylation in trigeminal spinal subnucleus caudalis neurons is involved in pain associated with dry tongue.
    Molecular pain, 2016, Volume: 12

    Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Male; Neurons; Nociception; Pain; P

2016
Differential expression of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse hippocampus induced by various nociceptive stimuli.
    Neuroscience, 2008, Oct-15, Volume: 156, Issue:3

    Topics: Acetic Acid; Analysis of Variance; Animals; Behavior, Animal; Benzylamines; Calcium-Calmodulin-Depen

2008
Differential roles of peripheral mitogen-activated protein kinase signal transduction pathways in bee venom-induced nociception and inflammation in conscious rats.
    The journal of pain, 2009, Volume: 10, Issue:2

    Topics: Animals; Bee Venoms; Behavior, Animal; Enzyme Inhibitors; Flavonoids; Hyperalgesia; Imidazoles; Infl

2009
Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord.
    Molecular pain, 2011, May-20, Volume: 7

    Topics: Animals; Behavior, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hyperalgesia; Imm

2011
Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice.
    Pharmacology, biochemistry, and behavior, 2012, Volume: 101, Issue:3

    Topics: Acetic Acid; Androstadienes; Animals; Anthracenes; Benzoquinones; Disease Models, Animal; Flavonoids

2012
Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord.
    Journal of neuroinflammation, 2012, Nov-27, Volume: 9

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Electromyography; Enzyme Inhibitors; Excitato

2012
Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats.
    Pain, 2003, Volume: 105, Issue:1-2

    Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Enzyme Inhibitors; Flavonoids; Ligation; Male;

2003
The kv4.2 potassium channel subunit is required for pain plasticity.
    Neuron, 2006, Apr-06, Volume: 50, Issue:1

    Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Blotting, West

2006
Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: an in vitro and in vivo study.
    The European journal of neuroscience, 2001, Volume: 14, Issue:7

    Topics: Animals; Calcitonin Gene-Related Peptide; Cell Count; Cells, Cultured; Cyclic AMP Response Element-B

2001