pd 98059 and Pain
pd 98059 has been researched along with Pain in 12 studies
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: inhibits MAP kinase kinase (MEK) activity, p42 MAPK and p44 MAPK; structure in first source
2-(2-amino-3-methoxyphenyl)chromen-4-one : A member of the class of monomethoxyflavones that is 3'-methoxyflavone bearing an additional amino substituent at position 2'.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pulpitis was confirmed by hematoxylin-eosin staining." | 1.51 | Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain. ( Jiang, W; Ni, L; Sun, J; Sun, S; Wang, W, 2019) |
Research
Studies (12)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (41.67) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Yoon, SY | 1 |
| Kwon, SG | 1 |
| Kim, YH | 1 |
| Yeo, JH | 1 |
| Ko, HG | 1 |
| Roh, DH | 1 |
| Kaang, BK | 1 |
| Beitz, AJ | 1 |
| Lee, JH | 1 |
| Oh, SB | 1 |
| Sun, S | 1 |
| Sun, J | 1 |
| Jiang, W | 1 |
| Wang, W | 1 |
| Ni, L | 1 |
| van den Heuvel, I | 1 |
| Reichl, S | 1 |
| Segelcke, D | 1 |
| Zahn, PK | 1 |
| Pogatzki-Zahn, EM | 1 |
| Nakaya, Y | 1 |
| Tsuboi, Y | 1 |
| Okada-Ogawa, A | 1 |
| Shinoda, M | 2 |
| Kubo, A | 1 |
| Chen, JY | 1 |
| Noma, N | 1 |
| Batbold, D | 1 |
| Imamura, Y | 1 |
| Sessle, BJ | 1 |
| Iwata, K | 2 |
| Seo, YJ | 1 |
| Kwon, MS | 1 |
| Choi, HW | 1 |
| Choi, SM | 1 |
| Kim, YW | 1 |
| Lee, JK | 1 |
| Park, SH | 1 |
| Jung, JS | 1 |
| Suh, HW | 1 |
| Chen, HS | 1 |
| He, X | 1 |
| Qu, F | 1 |
| Kang, SM | 1 |
| Yu, Y | 1 |
| Liao, D | 1 |
| Lu, SJ | 1 |
| Lee, Y | 1 |
| Pai, M | 1 |
| Brederson, JD | 1 |
| Wilcox, D | 1 |
| Hsieh, G | 1 |
| Jarvis, MF | 1 |
| Bitner, RS | 1 |
| Pavao-de-Souza, GF | 1 |
| Zarpelon, AC | 1 |
| Tedeschi, GC | 1 |
| Mizokami, SS | 1 |
| Sanson, JS | 1 |
| Cunha, TM | 1 |
| Ferreira, SH | 1 |
| Cunha, FQ | 1 |
| Casagrande, R | 1 |
| Verri, WA | 1 |
| Liu, MG | 1 |
| Matsuura, S | 1 |
| Honda, K | 1 |
| Suzuki, I | 1 |
| Shibuta, K | 1 |
| Tamagawa, T | 1 |
| Katagiri, A | 1 |
| Kiyomoto, M | 1 |
| Ohara, K | 1 |
| Furukawa, A | 1 |
| Urata, K | 1 |
| Lim, G | 1 |
| Sung, B | 1 |
| Ji, RR | 1 |
| Mao, J | 1 |
| Hu, HJ | 1 |
| Carrasquillo, Y | 1 |
| Karim, F | 1 |
| Jung, WE | 1 |
| Nerbonne, JM | 1 |
| Schwarz, TL | 1 |
| Gereau, RW | 1 |
| Ma, W | 1 |
| Zheng, WH | 1 |
| Powell, K | 1 |
| Jhamandas, K | 1 |
| Quirion, R | 1 |
Other Studies
12 other studies available for pd 98059 and Pain
| Article | Year |
|---|---|
A critical role of spinal Shank2 proteins in NMDA-induced pain hypersensitivity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Excitatory Amino Acid Agon | 2017 |
Nav1.7 via Promotion of ERK in the Trigeminal Ganglion Plays an Important Role in the Induction of Pulpitis Inflammatory Pain.
Topics: Animals; Dental Pulp Cavity; Disease Models, Animal; Flavonoids; Gene Expression Regulation; Inflamm | 2019 |
Selective prevention of mechanical hyperalgesia after incision by spinal ERK1/2 inhibition.
Topics: Animals; Flavonoids; Hyperalgesia; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kina | 2015 |
ERK-GluR1 phosphorylation in trigeminal spinal subnucleus caudalis neurons is involved in pain associated with dry tongue.
Topics: Animals; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Male; Neurons; Nociception; Pain; P | 2016 |
Differential expression of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse hippocampus induced by various nociceptive stimuli.
Topics: Acetic Acid; Analysis of Variance; Animals; Behavior, Animal; Benzylamines; Calcium-Calmodulin-Depen | 2008 |
Differential roles of peripheral mitogen-activated protein kinase signal transduction pathways in bee venom-induced nociception and inflammation in conscious rats.
Topics: Animals; Bee Venoms; Behavior, Animal; Enzyme Inhibitors; Flavonoids; Hyperalgesia; Imidazoles; Infl | 2009 |
Monosodium iodoacetate-induced joint pain is associated with increased phosphorylation of mitogen activated protein kinases in the rat spinal cord.
Topics: Animals; Behavior, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Hyperalgesia; Imm | 2011 |
Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice.
Topics: Acetic Acid; Androstadienes; Animals; Anthracenes; Benzoquinones; Disease Models, Animal; Flavonoids | 2012 |
Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Electromyography; Enzyme Inhibitors; Excitato | 2012 |
Upregulation of spinal cannabinoid-1-receptors following nerve injury enhances the effects of Win 55,212-2 on neuropathic pain behaviors in rats.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Enzyme Inhibitors; Flavonoids; Ligation; Male; | 2003 |
The kv4.2 potassium channel subunit is required for pain plasticity.
Topics: Action Potentials; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Blotting, West | 2006 |
Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: an in vitro and in vivo study.
Topics: Animals; Calcitonin Gene-Related Peptide; Cell Count; Cells, Cultured; Cyclic AMP Response Element-B | 2001 |