indazoles has been researched along with Pain in 28 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.57) | 18.7374 |
| 1990's | 4 (14.29) | 18.2507 |
| 2000's | 13 (46.43) | 29.6817 |
| 2010's | 8 (28.57) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Sotomayor-Zárate, R | 1 |
| Å Nilsson, JL; Blomgren, A; Blomqvist, A; Boudieu, L; Eschalier, A; Grundemar, L; Mallet, C; Nilsson, UJ; Shionoya, K; Sundin, AP; Zygmunt, PM | 1 |
| Akaogi, K; Endou, Y; Shirahashi, H; Suenaga, Y; Takashima, M; Toriihara, E; Wakabayashi, M; Yoshida, H | 1 |
| Bhattacharya, SK; Gupta, LK; Gupta, R | 1 |
| Chang, WT; Chao, YS; Chen, SC; Cheng, MF; Law, PY; Loh, HH; Ou, LC; Shih, C; Ueng, SH; Yeh, SH | 1 |
| Daanen, JF; DeGoey, DA; El-Kouhen, OF; Fricano, MM; Frost, JM; Ghoreishi-Haack, N; Gum, RJ; Hsieh, GC; Kort, ME; Lundgaard, GL; Matulenko, MA; Neelands, T; Pai, M; Shi, L; Zhan, C; Zhang, XF | 1 |
| Banfor, PN; Bayburt, E; Chandran, P; Daanen, JF; Faltynek, CR; Fryer, RM; Gauvin, DM; Ghilardi, JR; Gomtsyan, A; Hernandez, G; Honore, P; Jarvis, MF; Joshi, SK; Kort, ME; Kym, PR; Lee, CH; Mantyh, PW; Marsh, K; Mikusa, JP; Neelands, T; Reilly, RM; Segreti, JA; Sevcik, MA; Sullivan, JP; Surowy, CS; Zhong, C | 1 |
| Ulugol, A; Yilmaz, I | 1 |
| Chu, KL; Duan, RW; Faltynek, C; McGaraughty, S; Nothaft, W; Rowbotham, MC; Svensson, P; Wang, Y | 1 |
| De Rezende, ML; Mama, KR; Niyom, S | 1 |
| Best, AE; Duan, WR; Faltynek, CR; Locke, C; Nothaft, W; Othman, AA; Reeh, P; Schaffler, K | 1 |
| Bleedorn, JA; Cozzi, EM; Holzman, G; Jacobson, PB; Malek, S; Muir, P; Nemke, B; Sample, SJ; Schaefer, SL; Schwartz, Z | 1 |
| Chelly, JE; Doursout, MF; Liang, Y | 1 |
| Cury, Y; Longo, I; Zanchet, EM | 1 |
| Aypar, U; Dal, D; Iskit, AB; Salman, AE; Salman, MA | 1 |
| Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T | 1 |
| Bae, HB; Choi, JI; Chung, ST; Kim, CM; Kim, SJ; Yoon, MH | 1 |
| Bayburt, EK; Bianchi, B; Brown, B; Chandran, P; Cui, M; Decker, MW; Faltynek, CR; Gauvin, D; Gomtsyan, A; Hernandez, G; Honore, P; Lee, CH; Marsh, K; McDonald, H; Mikusa, J; Moreland, RB; Neelands, TR; Niforatos, W; Sullivan, JP; Zhong, C | 1 |
| Jiang, SJ; Qiu, J; Shen, JP; Yin, HL; Yin, XX; Yu, JX | 1 |
| Bagetta, G; Komatsu, T; Sakurada, C; Sakurada, S; Sakurada, T; Sanai, K; Sasaki, M; Tsuzuki, M | 1 |
| Bertorelli, R; Burnett, DA; Domalski, M; Fredduzzi, S; Greenlee, WJ; Li, C; Lozza, G; Reggiani, A; Veltri, A; Wu, WL | 1 |
| Bayburt, EK; Faltynek, CR; Gomtsyan, A; Hannick, SM; Honore, P; Jarvis, MF; Lee, CH; Marsh, KC; McDonald, HA; Schmidt, RG; Sullivan, JP; Surowy, CS; Wetter, JM | 1 |
| Eapen, L; Evans, WK; Genest, P; Girard, A; Stewart, DJ; Verma, S | 1 |
| Hao, JX; Xu, XJ | 1 |
| Fukuda, T; Harukuni, I; Saito, S; Sato, S; Toyooka, H | 1 |
| Kawabata, A; Kawao, N; Kuroda, R; Shigenaga, Y; Takemura, M; Umeda, W; Yoshimura, H | 1 |
| Moss, HE; Sanger, GJ | 1 |
| Band, PR; Besner, JG; Coppin, CM; Eisenhauer, EA; Stewart, D; Weinerman, BH | 1 |
6 trial(s) available for indazoles and Pain
| Article | Year |
|---|---|
Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial.
Topics: Abdomen; Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indazoles; Male; Middle Aged; Pain; Pain Threshold; Skin; Thermosensing; Time Factors; TRPV Cation Channels; Urea; Young Adult | 2011 |
Comparison of the analgesic efficacy of oral ABT-116 administration with that of transmucosal buprenorphine administration in dogs.
Topics: Administration, Mucosal; Analgesics, Opioid; Animals; Buprenorphine; Cross-Over Studies; Dogs; Female; Indazoles; Male; Pain; Pain Measurement; Phenylurea Compounds; TRPV Cation Channels | 2012 |
An oral TRPV1 antagonist attenuates laser radiant-heat-evoked potentials and pain ratings from UV(B)-inflamed and normal skin.
Topics: Administration, Oral; Adult; Analgesics, Opioid; Cross-Over Studies; Cyclooxygenase 2 Inhibitors; Double-Blind Method; Etoricoxib; Evoked Potentials; Hot Temperature; Humans; Indazoles; Lasers, Gas; Male; Pain; Pain Measurement; Pyridines; Severity of Illness Index; Skin; Sulfones; Tramadol; TRPV Cation Channels; Ultraviolet Rays; Urea | 2013 |
Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Carbazoles; Dog Diseases; Dogs; Double-Blind Method; Female; Heart Rate; Indazoles; Lameness, Animal; Male; Osteoarthritis, Hip; Pain; Phenylurea Compounds; Placebo Effect; Respiration; Tramadol; Treatment Outcome | 2012 |
Phase II study of lonidamine plus radiotherapy in the treatment of brain metastases.
Topics: Adult; Aged; Brain Neoplasms; Combined Modality Therapy; Cranial Irradiation; Dexamethasone; Female; Humans; Indazoles; Male; Middle Aged; Muscular Diseases; Pain; Survival Analysis; Treatment Outcome | 1993 |
Phase II study of lonidamine in patients with metastatic renal cell carcinoma: a National Cancer Institute of Canada Clinical Trials Group Study.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Renal Cell; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Female; Humans; Indazoles; Kidney Neoplasms; Male; Middle Aged; Nausea; Pain; Pyrazoles; Testis; Testosterone | 1986 |
22 other study(ies) available for indazoles and Pain
| Article | Year |
|---|---|
Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Formaldehyde; Humans; Indazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociception; Nociceptors; Pain; Pain Measurement | 2020 |
Paracetamol analogues conjugated by FAAH induce TRPV1-mediated antinociception without causing acute liver toxicity.
Topics: Acetaminophen; Amidohydrolases; Aminophenols; Analgesics; Animals; Antipyretics; Arachidonic Acids; Brain; Female; Humans; Indazoles; Liver; Male; Mice, Inbred C57BL; Models, Molecular; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats, Wistar; Structure-Activity Relationship; Transient Receptor Potential Channels; TRPV Cation Channels | 2021 |
The discovery of novel 3-aryl-indazole derivatives as peripherally restricted pan-Trk inhibitors for the treatment of pain.
Topics: Dose-Response Relationship, Drug; Drug Discovery; Humans; Indazoles; Molecular Structure; Pain; Protein Kinase Inhibitors; Receptor Protein-Tyrosine Kinases; Structure-Activity Relationship | 2019 |
Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole.
Topics: Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Formaldehyde; Hot Temperature; Hyperalgesia; Indazoles; Male; Mice; Modafinil; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain | 2014 |
Discovery, structure-activity relationship studies, and anti-nociceptive effects of 1-phenyl-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one as novel opioid receptor agonists.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Indazoles; Mice; Mice, Congenic; Molecular Structure; Pain; Pain Measurement; Receptors, Opioid, kappa; Receptors, Opioid, mu; Structure-Activity Relationship; Tail | 2014 |
Substituted Indazoles as Nav1.7 Blockers for the Treatment of Pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Evoked Potentials; Imidazolidines; Indazoles; Iodoacetic Acid; Molecular Structure; NAV1.7 Voltage-Gated Sodium Channel; Osteoarthritis; Pain; Pain Measurement; Pyrroles; Rats; Sodium Channel Blockers; Structure-Activity Relationship | 2016 |
Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia.
Topics: Analgesics; Animals; Body Temperature; Bone Neoplasms; Calcium; Disease Models, Animal; Drug Interactions; Fever; Indazoles; Inflammation; Male; Mice; Mice, Inbred C3H; Motor Activity; Osteoarthritis; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; TRPV Cation Channels; Urea | 2009 |
The effect of nitric oxide synthase inhibitors on the development of analgesic tolerance to dipyrone in mice.
Topics: Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Drug Tolerance; Enzyme Inhibitors; Female; Guanidines; Hot Temperature; Indazoles; Linear Models; Male; Mice; Mice, Inbred Strains; Nitric Oxide Synthase; Pain; Pain Measurement | 2009 |
NOS inhibitors exhibit antinociceptive properties in the rat formalin test.
Topics: Analgesics; Animals; Arginine; Blood Pressure; Enzyme Inhibitors; Formaldehyde; Guanidines; Heart Rate; Indazoles; Nitric Oxide Synthase; Nitroarginine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sodium Chloride; Time Factors | 2003 |
Involvement of spinal neurokinins, excitatory amino acids, proinflammatory cytokines, nitric oxide and prostanoids in pain facilitation induced by Phoneutria nigriventer spider venom.
Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide Receptor Antagonists; Celecoxib; Citrates; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hyperalgesia; Indazoles; Interleukin-1; Lysine; Male; Neurokinin-1 Receptor Antagonists; Nitric Oxide Synthase; Pain; Physalaemin; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Receptors, Neurokinin-1; Spider Venoms; Spinal Cord; Sulfonamides; Tumor Necrosis Factor-alpha | 2004 |
The involvement of nitric oxide on the analgesic effect of tramadol.
Topics: Analgesics; Analgesics, Opioid; Animals; Drug Synergism; Female; Indazoles; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Tramadol | 2006 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Diazoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indazoles; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Okadaic Acid; Oxadiazoles; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Spinal Nerves; Stereoisomerism; Time Factors; Vasodilator Agents | 2006 |
Lack of reciprocity between opioid and 5-HT3 receptors for antinociception in rat spinal cord.
Topics: Analgesia; Analgesics, Opioid; Animals; Biguanides; Dose-Response Relationship, Drug; Formaldehyde; Hindlimb; Indazoles; Injections, Spinal; Male; Morphine; Motor Activity; Muscle Tonus; Naloxone; Narcotic Antagonists; Ondansetron; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists; Serotonin Receptor Agonists; Spinal Cord; Tropanes | 2006 |
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists.
Topics: Administration, Oral; Analgesics; Animals; Arthralgia; Calcium; Capsaicin; Cell Line; Cells, Cultured; Central Nervous System; Disease Models, Animal; Humans; Hyperalgesia; Indazoles; Inflammation Mediators; Injections, Spinal; Male; Nociceptors; Pain; Pyridines; Rats; Rats, Sprague-Dawley; Sulfones; Treatment Outcome; TRPV Cation Channels; Urea | 2006 |
Protective effects of bendazac lysine on diabetic peripheral neuropathy in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Erythrocytes; Glutathione Peroxidase; Glycated Hemoglobin; Glycation End Products, Advanced; Indazoles; Insulin; Male; Myelin Sheath; Pain; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Sural Nerve | 2006 |
Extracellular signal-regulated kinase (ERK) and nitric oxide synthase mediate intrathecal morphine-induced nociceptive behavior.
Topics: Amidines; Analgesics, Opioid; Animals; Behavior, Animal; Benzylamines; Blotting, Western; Butadienes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Indazoles; Injections, Spinal; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitriles; Nociceptors; Pain; Signal Transduction | 2007 |
Discovery of orally efficacious tetracyclic metabotropic glutamate receptor 1 (mGluR1) antagonists for the treatment of chronic pain.
Topics: Analgesics; Animals; Area Under Curve; Chronic Disease; Heterocyclic Compounds, 4 or More Rings; Humans; Indazoles; Morpholines; Pain; Peripheral Nervous System Diseases; Pyridines; Pyrroles; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship | 2007 |
Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management.
Topics: Administration, Oral; Analgesics; Animals; Biological Availability; Dogs; Haplorhini; Humans; In Vitro Techniques; Indazoles; Indenes; Microsomes, Liver; Pain; Rats; Stereoisomerism; Structure-Activity Relationship; TRPV Cation Channels; Urea | 2008 |
Treatment of a chronic allodynia-like response in spinally injured rats: effects of systemically administered nitric oxide synthase inhibitors.
Topics: Adrenergic Agonists; Analgesics; Animals; Arousal; Blood Pressure; Chronic Disease; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Female; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Physical Stimulation; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 1996 |
Halothane minimum alveolar anesthetic concentration and neuronal nitric oxide synthase activity of the dorsal horn and the locus ceruleus in rats.
Topics: Anesthetics, Inhalation; Animals; Axons; Coloring Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Halothane; Indazoles; Injections, Intraperitoneal; Locus Coeruleus; Male; NADPH Dehydrogenase; Neurons; Nitric Oxide; Nitric Oxide Synthase; Pain; Rats; Rats, Sprague-Dawley; Signal Transduction; Spinal Cord | 1999 |
Secondary somatosensory cortex stimulation facilitates the antinociceptive effect of the NO synthase inhibitor through suppression of spinal nociceptive neurons in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Electric Stimulation; Enzyme Inhibitors; Indazoles; Injections, Intraperitoneal; Injections, Spinal; Male; Methysergide; Naloxone; Narcotic Antagonists; Neural Inhibition; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nociceptors; Pain; Pain Measurement; Phentolamine; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Serotonin Antagonists; Somatosensory Cortex; Spinal Cord | 2001 |
The effects of granisetron, ICS 205-930 and ondansetron on the visceral pain reflex induced by duodenal distension.
Topics: Animals; Blood Pressure; Duodenum; Granisetron; Imidazoles; Indazoles; Indoles; Male; Morphine; Muscle Contraction; Muscle, Smooth; Ondansetron; Pain; Pyrazoles; Rats; Rats, Inbred Strains; Reflex; Serotonin Antagonists; Stomach; Tropisetron; Vagotomy | 1990 |