5-azaindole profile

5-Azaindole is a heterocyclic compound that is structurally similar to indole, but with a nitrogen atom replacing the carbon atom at the 5-position. It is a synthetic compound that has been extensively studied for its biological activities. 5-azaindole has been shown to have a variety of effects on biological systems, including inhibition of DNA methylation, anti-cancer activity, and modulation of immune responses. Its ability to inhibit DNA methylation has made it a valuable tool in epigenetic research and has led to the development of clinical trials for cancer treatment. The compound's biological effects are attributed to its ability to act as a substrate for enzymes involved in DNA methylation, such as DNMT1. 5-azaindole is often used as a research tool to study the role of DNA methylation in various biological processes. Researchers are investigating its potential therapeutic applications in conditions such as cancer, autoimmune diseases, and developmental disorders.'

ID Source	ID
PubMed CID	9220
CHEMBL ID	5192772
SCHEMBL ID	67000
SCHEMBL ID	15518410
MeSH ID	M0500564

Synonym
AC-860
brn 0109684
1,5-diazaindene
1h-pyrrolo(3,2-c)pyridine
3,7-dideazapurine
inchi=1/c7h6n2/c1-4-9-7-2-3-8-5-6(1)7/h1-5,9
271-34-1
5-azaindole ,
A-9490
1h-pyrrolo[3,2-c]pyridine
AKOS006375099
FT-0658762
A5297
AKOS005254365
pyrrolo[3,2-c]pyridine
5-23-06-00304 (beilstein handbook reference)
1h-pyrrolo[3,2-c]pyridine (5-azaindole)
A818927
A818926
271-32-9
P1896
STL220653
FT-0601478
PS-5437
AM20051018
PB12213
SCHEMBL67000
mfcd00955936
SY009136
SCHEMBL15518410
1h-pyrrolo [3,2-c]pyridine
5-aza-indole
SRSKXJVMVSSSHB-UHFFFAOYSA-N
DTXSID80181563
CS-W002711
CHEMBL5192772
BCP27104
EN300-67413
BBL100076
HY-W002711
Z1079456082

Assay ID	Title	Year	Journal	Article
AID1891831	Lipid-water distribution ratio of the compound	2022	Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9	Development of Azaindole-Based Frameworks as Potential Antiviral Agents and Their Future Perspectives.
AID1891830	Basic dissociation constant, pKa of the compound	2022	Journal of medicinal chemistry, 05-12, Volume: 65, Issue:9	Development of Azaindole-Based Frameworks as Potential Antiviral Agents and Their Future Perspectives.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (6.25)	18.7374
1990's	0 (0.00)	18.2507
2000's	6 (37.50)	29.6817
2010's	7 (43.75)	24.3611
2020's	2 (12.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (6.25%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (93.75%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
indole [no description available]	3.51	1	indole; polycyclic heteroarene	Escherichia coli metabolite
pyrazole 1H-pyrazole : The 1H-tautomer of pyrazole.	2.04	1	pyrazole
pyridine azine : An organonitrogen compound of general structure RCH=N-N=CHR or RR'C=N-N=CRR'.	2.05	1	azaarene; mancude organic heteromonocyclic parent; monocyclic heteroarene; pyridines	environmental contaminant; NMR chemical shift reference compound
2,2'-dipyridyl 2,2'-Dipyridyl: A reagent used for the determination of iron.. 2,2'-bipyridine : A bipyridine in which the two pyridine moieties are linked by a bond between positions C-2 and C-2'.	2.11	1	bipyridine	chelator; ferroptosis inhibitor
benzimidazole 1H-benzimidazole : The 1H-tautomer of benzimidazole.	2.11	1	benzimidazole; polycyclic heteroarene
methionine Methionine: A sulfur-containing essential L-amino acid that is important in many body functions.. methionine : A sulfur-containing amino acid that is butyric acid bearing an amino substituent at position 2 and a methylthio substituent at position 4.	2.41	1	aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid	antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical
cyclopropane cyclopropane : A cycloalkane composed of three carbon atoms to form a ring.	7.05	1	cycloalkane; cyclopropanes	inhalation anaesthetic
quinoline [no description available]	2.11	1	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinolines
pyrroles 1H-pyrrole : A tautomer of pyrrole that has the double bonds at positions 2 and 4.. pyrrole : A five-membered monocyclic heteroarene comprising one NH and four CH units which forms the parent compound of the pyrrole group of compounds. Its five-membered ring structure has three tautomers. A 'closed class'.. azole : Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen.	2.04	1	pyrrole; secondary amine
piperidine [no description available]	2.05	1	azacycloalkane; piperidines; saturated organic heteromonocyclic parent; secondary amine	base; catalyst; human metabolite; non-polar solvent; plant metabolite; protic solvent; reagent
6-azaindole [no description available]	3.87	3
indazoles Indazoles: A group of heterocyclic aromatic organic compounds consisting of the fusion of BENZENE and PYRAZOLES.	2.11	1	indazole
7-azaindole [no description available]	3.51	1	pyrrolopyridine
4-azaindole [no description available]	3.89	3
alpha-aminopyridine alpha-aminopyridine: RN given refers to parent cpd; structure in Merck Index, 9th ed, #485. aminopyridine : Compounds containing a pyridine skeleton substituted by one or more amine groups.	2.05	1
palladium Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.	2.47	2	metal allergen; nickel group element atom; platinum group metal atom
ruthenium Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.	2.11	1	iron group element atom; platinum group metal atom
bms-488043 BMS-488043: anti-HIV agent	3.51	1
bms-585248 [no description available]	3.51	1
piperidines Piperidines: A family of hexahydropyridines.	2.05	1

Condition	Relationship Strength	Studies
Grippe [description not available]	3.33	1
Influenza, Human An acute viral infection in humans involving the respiratory tract. It is marked by inflammation of the NASAL MUCOSA; the PHARYNX; and conjunctiva, and by headache and severe, often generalized, myalgia.	3.33	1
Chronic Illness [description not available]	2.05	1
Ache [description not available]	2.05	1
Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).	2.05	1
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	7.05	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.02	1

5-azaindole

Cross-References

Synonyms (41)

Bioassays (2)

Research

Studies (16)

Market Indicators

Research Demand Index: 27.96

Study Types