gentiacaulein profile

gentiacaulein: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

gentiacaulein : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 2 and 8 and methoxy groups at positions 1 and 6. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	5281634
CHEMBL ID	467590
CHEBI ID	5313
MeSH ID	M0456490

Synonym
2,8-dihydroxy-1,6-dimethoxy-xanthen-9-one
2,8-dihydroxy-1,6-dimethoxy-9h-xanthen-9-one
2,6-dimethoxyxanthone
nsc-661743
nsc661743
MLS000563494 ,
smr000232301
15402-27-4
gentiacaulein
2,8-dihydroxy-1,6-dimethoxyxanthone
CHEMBL467590
getiacaulein
chebi:5313 ,
2,8-dihydroxy-1,6-dimethoxyxanthen-9-one
AC1NQYS1 ,
HMS2227I16
HMS3338N03
DTXSID10415161
bdbm174835
us9114126, 2027ba1
1,7-dihydroxy-3,8-dimethoxyxanthone
Q27106712

Role	Description
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
xanthones	Any member of the class of xanthenes based on a xanthone skeleton.
polyphenol	Members of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group.
aromatic ether	Any ether in which the oxygen is attached to at least one aryl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, 2-oxoglutarate Oxygenase	Homo sapiens (human)	Potency	28.1838	0.1778	14.3909	39.8107	AID2147
Luciferase	Photinus pyralis (common eastern firefly)	Potency	19.0115	0.0072	15.7588	89.3584	AID588342
glp-1 receptor, partial	Homo sapiens (human)	Potency	14.1254	0.0184	6.8060	14.1254	AID624417
ATAD5 protein, partial	Homo sapiens (human)	Potency	20.7329	0.0041	10.8903	31.5287	AID504466; AID504467
USP1 protein, partial	Homo sapiens (human)	Potency	8.9125	0.0316	37.5844	354.8130	AID743255
TDP1 protein	Homo sapiens (human)	Potency	22.7265	0.0008	11.3822	44.6684	AID686978; AID686979
Microtubule-associated protein tau	Homo sapiens (human)	Potency	12.5893	0.1800	13.5574	39.8107	AID1460
aldehyde dehydrogenase 1 family, member A1	Homo sapiens (human)	Potency	22.3872	0.0112	12.4002	100.0000	AID1030
P53	Homo sapiens (human)	Potency	50.1187	0.0731	9.6858	31.6228	AID504706
euchromatic histone-lysine N-methyltransferase 2	Homo sapiens (human)	Potency	79.4328	0.0355	20.9770	89.1251	AID504332
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	Homo sapiens (human)	Potency	14.1254	0.0018	15.6638	39.8107	AID894
nuclear factor erythroid 2-related factor 2 isoform 2	Homo sapiens (human)	Potency	29.0929	0.0041	9.9848	25.9290	AID504444
nuclear receptor ROR-gamma isoform 1	Mus musculus (house mouse)	Potency	12.5893	0.0079	8.2332	1,122.0200	AID2551
Vpr	Human immunodeficiency virus 1	Potency	63.0957	1.5849	19.6264	63.0957	AID651644
lamin isoform A-delta10	Homo sapiens (human)	Potency	15.8489	0.8913	12.0676	28.1838	AID1487
TAR DNA-binding protein 43	Homo sapiens (human)	Potency	2.8184	1.7783	16.2081	35.4813	AID652104
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
negative regulation of protein phosphorylation	TAR DNA-binding protein 43	Homo sapiens (human)
mRNA processing	TAR DNA-binding protein 43	Homo sapiens (human)
RNA splicing	TAR DNA-binding protein 43	Homo sapiens (human)
negative regulation of gene expression	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of protein stability	TAR DNA-binding protein 43	Homo sapiens (human)
positive regulation of insulin secretion	TAR DNA-binding protein 43	Homo sapiens (human)
response to endoplasmic reticulum stress	TAR DNA-binding protein 43	Homo sapiens (human)
positive regulation of protein import into nucleus	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of circadian rhythm	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of apoptotic process	TAR DNA-binding protein 43	Homo sapiens (human)
negative regulation by host of viral transcription	TAR DNA-binding protein 43	Homo sapiens (human)
rhythmic process	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of cell cycle	TAR DNA-binding protein 43	Homo sapiens (human)
3'-UTR-mediated mRNA destabilization	TAR DNA-binding protein 43	Homo sapiens (human)
3'-UTR-mediated mRNA stabilization	TAR DNA-binding protein 43	Homo sapiens (human)
nuclear inner membrane organization	TAR DNA-binding protein 43	Homo sapiens (human)
amyloid fibril formation	TAR DNA-binding protein 43	Homo sapiens (human)
regulation of gene expression	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
RNA polymerase II cis-regulatory region sequence-specific DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
double-stranded DNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
RNA binding	TAR DNA-binding protein 43	Homo sapiens (human)
mRNA 3'-UTR binding	TAR DNA-binding protein 43	Homo sapiens (human)
protein binding	TAR DNA-binding protein 43	Homo sapiens (human)
lipid binding	TAR DNA-binding protein 43	Homo sapiens (human)
identical protein binding	TAR DNA-binding protein 43	Homo sapiens (human)
pre-mRNA intronic binding	TAR DNA-binding protein 43	Homo sapiens (human)
molecular condensate scaffold activity	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
intracellular non-membrane-bounded organelle	TAR DNA-binding protein 43	Homo sapiens (human)
nucleus	TAR DNA-binding protein 43	Homo sapiens (human)
nucleoplasm	TAR DNA-binding protein 43	Homo sapiens (human)
perichromatin fibrils	TAR DNA-binding protein 43	Homo sapiens (human)
mitochondrion	TAR DNA-binding protein 43	Homo sapiens (human)
cytoplasmic stress granule	TAR DNA-binding protein 43	Homo sapiens (human)
nuclear speck	TAR DNA-binding protein 43	Homo sapiens (human)
interchromatin granule	TAR DNA-binding protein 43	Homo sapiens (human)
nucleoplasm	TAR DNA-binding protein 43	Homo sapiens (human)
chromatin	TAR DNA-binding protein 43	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (42)

Assay ID	Title	Year	Journal	Article
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1347083	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347086	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347082	qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal	2020	Antiviral research, 01, Volume: 173	A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID384219	Antiproliferative activity against human U251 cells assessed as mitochondrial dehydrogenase activity after 24 hrs by MTT assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384240	Antiproliferative activity against Albino Oxford rat peritoneal macrophages assessed as mitochondrial respiration after 48 hrs by MTT assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384217	Antiproliferative activity against rat C6 cells assessed as cell number after 24 hrs by crystal violet assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384231	Induction apoptosis in rat C6 cells assessed as caspase activation at 50 uM after 36 hrs by flow cytometry relative to control	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384239	Antiproliferative activity against Albino Oxford rat peritoneal macrophages assessed as cell number after 48 hrs by crystal violet assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384222	Antiproliferative activity against rat C6 cells assessed as mitochondrial dehydrogenase activity after 72 hrs by MTT assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384225	Cell cycle arrest in rat C6 cells assessed as accumulation at S phase at 50 uM after 24 hrs by flow cytometry relative to control	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384235	Antiproliferative activity against rat C6 cells assessed as cell number after 48 hrs by crystal violet assay in presence of N-acetyl-cysteine	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384221	Antiproliferative activity against human U251 cells assessed as cell number after 72 hrs by crystal violet assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384214	Antiproliferative activity against human U251 cells assessed as cell number after 24 hrs by crystal violet assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384226	Cell cycle arrest in rat C6 cells assessed as accumulation at G2/M phase at 50 uM after 24 hrs by flow cytometry relative to control	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384223	Antiproliferative activity against human U251 cells assessed as mitochondrial dehydrogenase activity after 72 hrs by MTT assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384227	Inhibition of bovine brain tubulin by microtubule depolymerization assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384234	Antiproliferative activity against rat C6 cells assessed as caspase activation at 50 uM after 36 hrs by flow cytometry in presence of N-acetyl-cysteine	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384232	Induction of mitochondrial membrane potential depolarization in rat C6 cells assessed as increase in green to red fluorescence ratio at 50 uM after 24 hrs by flow cytometry	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384237	Antiproliferative activity against Albino Oxford rat primary astrocytes assessed as mitochondrial respiration after 48 hrs by MTT assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384224	Cell cycle arrest in rat C6 cells assessed as accumulation at G0/G1 phase at 50 uM after 24 hrs by flow cytometry relative to control	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384238	Antiproliferative activity against Albino Oxford rat primary astrocytes assessed as change in morphology by bright field microscopy	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384218	Antiproliferative activity against rat C6 cells assessed as mitochondrial dehydrogenase activity after 24 hrs by MTT assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384236	Antiproliferative activity against Albino Oxford rat primary astrocytes assessed as cell number after 48 hrs by crystal violet assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384230	Induction apoptosis in rat C6 cells at 50 uM after 36 hrs by flow cytometry relative to control	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384216	Antiproliferative activity against human U251 cells assessed as cell number after 48 hrs by crystal violet assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384215	Antiproliferative activity against rat C6 cells assessed as cell number after 48 hrs by crystal violet assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384220	Antiproliferative activity against rat C6 cells assessed as cell number after 72 hrs by crystal violet assay	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384233	Induction of reactive oxygen species production in rat C6 cells at 50 uM after 36 hrs by flow cytometry	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
AID384229	Induction necrosis in rat C6 cells at 50 uM after 36 hrs by flow cytometry relative to control	2008	Bioorganic & medicinal chemistry, May-15, Volume: 16, Issue:10	Antiglioma action of xanthones from Gentiana kochiana: Mechanistic and structure-activity requirements.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (38.46)	29.6817
2010's	6 (46.15)	24.3611
2020's	2 (15.38)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	13 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
acetic acid Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed). acetic acid : A simple monocarboxylic acid containing two carbons.	2.1	1	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent
ether Ether: A mobile, very volatile, highly flammable liquid used as an inhalation anesthetic and as a solvent for waxes, fats, oils, perfumes, alkaloids, and gums. It is mildly irritating to skin and mucous membranes.. ether : An organooxygen compound with formula ROR, where R is not hydrogen.. diethyl ether : An ether in which the oxygen atom is linked to two ethyl groups.	2.02	1	ether; volatile organic compound	inhalation anaesthetic; non-polar solvent; refrigerant
imipramine Imipramine: The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.. imipramine : A dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.	2.02	1	dibenzoazepine	adrenergic uptake inhibitor; antidepressant; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
xanthone xanthone : The parent compound of the xanthone class consisting of xanthene bearing a single oxo substituent at position 9.	7.01	1	xanthones	insecticide
oleanolic acid [no description available]	2.02	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.04	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
glucose, (beta-d)-isomer beta-D-glucose : D-Glucopyranose with beta configuration at the anomeric centre.. (1->4)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->4) linkages.. (1->3)-beta-D-glucan : A beta-D-glucan in which the glucose units are connected by (1->3) linkages.	2.06	1	D-glucopyranose	epitope; mouse metabolite
1,1-diphenyl-2-picrylhydrazyl 1,1-diphenyl-2-picrylhydrazyl: A diphenyl picrate; the ability to decolorize this stable radical indicates reactivity of tested compounds (Banda, Anal Chem 46:1772-7 1974)	2.1	1
cytellin cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982	2.02	1
bellidifolin bellidifolin: isolated from Swertia japonica; structure given in first source. bellidifolin : A member of the xanthone family that is bellidin substituted with a methyl group at O-3. A natural product found particularly in Swertia chirata and Gentianella campestris.	2.43	2	polyphenol; xanthones	EC 3.1.1.7 (acetylcholinesterase) inhibitor; hypoglycemic agent; metabolite
demethylbellidifolin demethylbellidifolin: protects the myocardium against damage due to ischemia-reperfusion in rats. bellidin : A member of the class of xanthones that is xanthone which is substituted by hydroxy groups at positions 1, 3, 5, and 8. A natural product found particularly in Iris nigricans and Gentiana campestris.	2.04	1	tetrol; xanthones	antioxidant; EC 3.1.1.7 (acetylcholinesterase) inhibitor; metabolite; mutagen; radical scavenger
1,2,8-trihydroxy-6-methoxyxanthone 1,2,8-trihydroxy-6-methoxyxanthone: has antidiabetic, antihyperlipidemic, and antioxidant activities; isolated from Swertia corymbosa; structure in first source. swertianin : A member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 2 and 8 and a methoxy group at position 6. It has been isolated from various species of the genus Swertia and has been found to exhibit antioxidant activities.	2.72	3	aromatic ether; polyphenol; xanthones	antioxidant; plant metabolite
decussatin decussatin: a Swertia decussata xanthone; structure in first source. decussatin : A member of the class of xanthones that is xanthone substituted by a hydroxy group at position 1 and methoxy groups at positions 1, 2 and 6. It has been isolated from Centaurium erythraea and Gentiana verna.	2.04	1	aromatic ether; phenols; xanthones	plant metabolite

Condition	Relationship Strength	Studies
Glial Cell Tumors [description not available]	2.04	1
Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)	2.04	1
Innate Inflammatory Response [description not available]	2.48	2
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.48	2
Anasarca [description not available]	2.1	1
Ache [description not available]	2.1	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.1	1
Pain An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.	2.1	1
Alloxan Diabetes [description not available]	2.05	1

gentiacaulein

Description

Cross-References

Synonyms (22)

Roles (1)

Drug Classes (3)

Protein Targets (16)

Potency Measurements

Biological Processes (18)

Molecular Functions (10)

Ceullar Components (9)

Bioassays (42)

Research

Studies (13)

Study Types

gentiacaulein

Description

Cross-References

Synonyms (22)

Roles (1)

Drug Classes (3)

Protein Targets (16)

Potency Measurements

Biological Processes (18)

Molecular Functions (10)

Ceullar Components (9)

Bioassays (42)

Research

Studies (13)

Study Types

Related Drugs (13)

Related Conditions (9)