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tiopronin and Pain

tiopronin has been researched along with Pain in 11 studies

Tiopronin: Sulfhydryl acylated derivative of GLYCINE.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"5 mg/kg of GB 52, a highly potent derivative of the enkephalinase inhibitor, thiorphan, were studied on the threshold of both the nociceptive reflex (Tr) and sensation of pain (Tp) as well as on the thresholds of both recruitment of the maximal nociceptive reflex response (Tmr) and tolerable pain (Tip), elicited by electrical stimulation of the sural nerve in normal and relaxed volunteers."3.67The enkephalinase inhibitor, GB 52, does not affect nociceptive flexion reflexes nor pain sensation in humans. ( Ernst, M; Roby, A; Willer, JC, 1986)
"To confirm that endogenous opioid-peptidergic systems and monoaminergic systems participate in the regulation of pain, the effects of a narcotic antagonist naloxone, inhibitors of enkephalin-degrading enzymes and monoaminergic blockers on persistent pain induced by formalin were investigated."3.67Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain. ( Kuraishi, Y; Satoh, M; Sugimoto, M; Takagi, H, 1986)
"The effect of the inhibition of aminopeptidase and enkephalinase A on the pain threshold of mice and rats was investigated, using bestatin and thiorphan as selective peptidase inhibitors."3.66Effect of inhibition of neuropeptidases on the pain threshold of mice and rats. ( Carenzi, A; Della Bella, D; Frigeni, V; Reggiani, A, 1983)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-199011 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chaillet, P1
Coulaud, A1
FourniƩ-Zaluski, MC3
Gacel, G1
Roques, BP3
Costentin, J1
Guilbaud, G2
Kayser, V2
Benoist, JM1
Gautron, M1
Carenzi, A1
Frigeni, V1
Reggiani, A1
Della Bella, D1
Carrozzini, B1
Selvaggio, G1
Villanueva, L1
Cadden, S1
Chitour, D1
Le Bars, D2
Willer, JC1
Roby, A1
Ernst, M1
Bourgoin, S1
Cesselin, F1
Hamon, M1
Dickenson, AH2
Hill, RG1
Hughes, J1
Pittaway, KM1
Sugimoto, M1
Kuraishi, Y1
Satoh, M1
Takagi, H1
Sullivan, AF1

Other Studies

11 other studies available for tiopronin and Pain

ArticleYear
Pain control by endogenous enkephalins is mediated by mu opioid receptors.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; P

1983
Depressive effects of morphine and of an enkephalinase inhibitor on responses of ventro-basal thalamic neurones to noxious stimuli.
    Life sciences, 1983, Volume: 33 Suppl 1

    Topics: Amino Acids, Sulfur; Animals; Morphine; Neprilysin; Neurons; Nociceptors; Pain; Protease Inhibitors;

1983
Effect of inhibition of neuropeptidases on the pain threshold of mice and rats.
    Neuropharmacology, 1983, Volume: 22, Issue:11

    Topics: Aminopeptidases; Animals; Endopeptidases; Enkephalin, Leucine; Leucine; Male; Mice; Neprilysin; Pain

1983
The analgesic effects of morphine, but not those of the enkephalinase inhibitor thiorphan, are enhanced in arthritic rats.
    Brain research, 1983, May-09, Volume: 267, Issue:1

    Topics: Amino Acids, Sulfur; Analgesia; Animals; Arthritis; Arthritis, Experimental; Male; Morphine; Naloxon

1983
[Long-term therapy of rheumatoid arthritis with alpha-mercaptopropionylglycine].
    Minerva medica, 1982, May-07, Volume: 73, Issue:19

    Topics: Adult; Amino Acids, Sulfur; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Lon

1982
Failure of ES 52, a highly potent enkephalinase inhibitor, to affect nociceptive transmission by rat dorsal horn convergent neurones.
    Brain research, 1985, Apr-29, Volume: 333, Issue:1

    Topics: Amino Acids, Sulfur; Animals; Enkephalins; Male; Nociceptors; Pain; Rats; Spinal Cord; Synaptic Tran

1985
The enkephalinase inhibitor, GB 52, does not affect nociceptive flexion reflexes nor pain sensation in humans.
    Neuropharmacology, 1986, Volume: 25, Issue:8

    Topics: Adult; Amino Acids, Sulfur; Electric Stimulation; Endopeptidases; Enkephalins; Female; Humans; Male;

1986
Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord.
    NIDA research monograph, 1986, Volume: 75

    Topics: Analgesics; Animals; Dipeptides; Enkephalin, Methionine; In Vitro Techniques; Leucine; Neurons; Pain

1986
Antinociceptive action of cholecystokinin octapeptide (CCK 8) and related peptides in rats and mice: effects of naloxone and peptidase inhibitors.
    Neuropharmacology, 1987, Volume: 26, Issue:4

    Topics: Animals; Captopril; FMRFamide; Gastrins; Leucine; Male; Mice; Naloxone; Neuropeptides; Pain; Proteas

1987
Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain.
    Neuropharmacology, 1986, Volume: 25, Issue:5

    Topics: Animals; Endorphins; Formaldehyde; Injections, Spinal; Leucine; Male; Medulla Oblongata; Naloxone; N

1986
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord.
    Brain research, 1987, Apr-07, Volume: 408, Issue:1-2

    Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural I

1987