tiopronin and Pain
tiopronin has been researched along with Pain in 11 studies
Tiopronin: Sulfhydryl acylated derivative of GLYCINE.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "5 mg/kg of GB 52, a highly potent derivative of the enkephalinase inhibitor, thiorphan, were studied on the threshold of both the nociceptive reflex (Tr) and sensation of pain (Tp) as well as on the thresholds of both recruitment of the maximal nociceptive reflex response (Tmr) and tolerable pain (Tip), elicited by electrical stimulation of the sural nerve in normal and relaxed volunteers." | 3.67 | The enkephalinase inhibitor, GB 52, does not affect nociceptive flexion reflexes nor pain sensation in humans. ( Ernst, M; Roby, A; Willer, JC, 1986) |
| "To confirm that endogenous opioid-peptidergic systems and monoaminergic systems participate in the regulation of pain, the effects of a narcotic antagonist naloxone, inhibitors of enkephalin-degrading enzymes and monoaminergic blockers on persistent pain induced by formalin were investigated." | 3.67 | Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain. ( Kuraishi, Y; Satoh, M; Sugimoto, M; Takagi, H, 1986) |
| "The effect of the inhibition of aminopeptidase and enkephalinase A on the pain threshold of mice and rats was investigated, using bestatin and thiorphan as selective peptidase inhibitors." | 3.66 | Effect of inhibition of neuropeptidases on the pain threshold of mice and rats. ( Carenzi, A; Della Bella, D; Frigeni, V; Reggiani, A, 1983) |
Research
Studies (11)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Chaillet, P | 1 |
| Coulaud, A | 1 |
| Fournié-Zaluski, MC | 3 |
| Gacel, G | 1 |
| Roques, BP | 3 |
| Costentin, J | 1 |
| Guilbaud, G | 2 |
| Kayser, V | 2 |
| Benoist, JM | 1 |
| Gautron, M | 1 |
| Carenzi, A | 1 |
| Frigeni, V | 1 |
| Reggiani, A | 1 |
| Della Bella, D | 1 |
| Carrozzini, B | 1 |
| Selvaggio, G | 1 |
| Villanueva, L | 1 |
| Cadden, S | 1 |
| Chitour, D | 1 |
| Le Bars, D | 2 |
| Willer, JC | 1 |
| Roby, A | 1 |
| Ernst, M | 1 |
| Bourgoin, S | 1 |
| Cesselin, F | 1 |
| Hamon, M | 1 |
| Dickenson, AH | 2 |
| Hill, RG | 1 |
| Hughes, J | 1 |
| Pittaway, KM | 1 |
| Sugimoto, M | 1 |
| Kuraishi, Y | 1 |
| Satoh, M | 1 |
| Takagi, H | 1 |
| Sullivan, AF | 1 |
Other Studies
11 other studies available for tiopronin and Pain
| Article | Year |
|---|---|
Pain control by endogenous enkephalins is mediated by mu opioid receptors.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Enkephalin, Methionine; Enkephalins; Leucine; Male; Mice; P | 1983 |
Depressive effects of morphine and of an enkephalinase inhibitor on responses of ventro-basal thalamic neurones to noxious stimuli.
Topics: Amino Acids, Sulfur; Animals; Morphine; Neprilysin; Neurons; Nociceptors; Pain; Protease Inhibitors; | 1983 |
Effect of inhibition of neuropeptidases on the pain threshold of mice and rats.
Topics: Aminopeptidases; Animals; Endopeptidases; Enkephalin, Leucine; Leucine; Male; Mice; Neprilysin; Pain | 1983 |
The analgesic effects of morphine, but not those of the enkephalinase inhibitor thiorphan, are enhanced in arthritic rats.
Topics: Amino Acids, Sulfur; Analgesia; Animals; Arthritis; Arthritis, Experimental; Male; Morphine; Naloxon | 1983 |
[Long-term therapy of rheumatoid arthritis with alpha-mercaptopropionylglycine].
Topics: Adult; Amino Acids, Sulfur; Arthritis, Rheumatoid; Drug Administration Schedule; Female; Humans; Lon | 1982 |
Failure of ES 52, a highly potent enkephalinase inhibitor, to affect nociceptive transmission by rat dorsal horn convergent neurones.
Topics: Amino Acids, Sulfur; Animals; Enkephalins; Male; Nociceptors; Pain; Rats; Spinal Cord; Synaptic Tran | 1985 |
The enkephalinase inhibitor, GB 52, does not affect nociceptive flexion reflexes nor pain sensation in humans.
Topics: Adult; Amino Acids, Sulfur; Electric Stimulation; Endopeptidases; Enkephalins; Female; Humans; Male; | 1986 |
Increase in met-enkephalin level and antinociceptive effects induced by kelatorphan in the rat spinal cord.
Topics: Analgesics; Animals; Dipeptides; Enkephalin, Methionine; In Vitro Techniques; Leucine; Neurons; Pain | 1986 |
Antinociceptive action of cholecystokinin octapeptide (CCK 8) and related peptides in rats and mice: effects of naloxone and peptidase inhibitors.
Topics: Animals; Captopril; FMRFamide; Gastrins; Leucine; Male; Mice; Naloxone; Neuropeptides; Pain; Proteas | 1987 |
Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain.
Topics: Animals; Endorphins; Formaldehyde; Injections, Spinal; Leucine; Male; Medulla Oblongata; Naloxone; N | 1986 |
Prevention of degradation of endogenous enkephalins produces inhibition of nociceptive neurones in rat spinal cord.
Topics: Action Potentials; Animals; Dipeptides; Enkephalins; Leucine; Male; Naloxone; Nerve Fibers; Neural I | 1987 |