Page last updated: 2024-10-27

gaboxadol and Pain

gaboxadol has been researched along with Pain in 9 studies

gaboxadol: GABA agonist; inhibitor of GABA uptake systems; structure

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"D-Baclofen is an antagonist at spinal baclofen receptors."1.27GABAergic mechanisms in antinociception. ( Sawynok, J, 1984)
" The maximum serum concentration was reached within 1 h after dosing in 87% of all administrations."1.27The analgesic effect of the GABA-agonist THIP in patients with chronic pain of malignant origin. A phase-1-2 study. ( Kjaer, M; Nielsen, H, 1983)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19908 (88.89)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, JP1
He, YT1
Duan, XL1
Suo, ZW1
Yang, X1
Hu, XD1
Sawynok, J1
Kjaer, M1
Nielsen, H1
Lindeburg, T1
Følsgård, S1
Sillesen, H1
Jacobsen, E1
Kehlet, H1
Menon, MK1
Clark, WG1
Vivonia, C1
Reyes-Vazquez, C1
Enna, SJ2
Dafny, N1
Zorn, SH1
Drower, EJ1
Hammond, DL1
Pelley, KA1
Vaught, JL1

Other Studies

9 other studies available for gaboxadol and Pain

ArticleYear
Enhanced Activities of δ Subunit-containing GABA
    Neuroscience, 2018, 02-10, Volume: 371

    Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; GABA-A Receptor Agonists; Isoxazoles; Long-

2018
GABAergic mechanisms in antinociception.
    Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:4-6

    Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Analgesics; Animals; Baclofen; Bicuculline; Central Ne

1984
The analgesic effect of the GABA-agonist THIP in patients with chronic pain of malignant origin. A phase-1-2 study.
    British journal of clinical pharmacology, 1983, Volume: 16, Issue:5

    Topics: Adult; Aged; Analgesics; Analysis of Variance; Chronic Disease; Drug Evaluation; Female; Humans; Iso

1983
Analgesic, respiratory and endocrine responses in normal man to THIP, a GABA-agonist.
    Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:1

    Topics: Adult; Analgesics; Dental Pulp Test; Double-Blind Method; Hormones; Humans; Hydrocortisone; Isoxazol

1983
Interaction between phencyclidine (PCP) and GABA-ergic drugs: clinical implications.
    Pharmacology, biochemistry, and behavior, 1980, Volume: 12, Issue:1

    Topics: Aminooxyacetic Acid; Anesthesia; Animals; Baclofen; Dextroamphetamine; Diazepam; Drug Interactions;

1980
The parafasciculus thalami as a site for mediating the antinociceptive response to GABAergic drugs.
    Brain research, 1986, Sep-24, Volume: 383, Issue:1-2

    Topics: Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Pain; Rats; Rats, Inbred Strains; Rece

1986
The GABA agonist THIP, attenuates antinociception in the mouse by modifying central cholinergic transmission.
    Neuropharmacology, 1987, Volume: 26, Issue:5

    Topics: Afferent Pathways; Analgesics; Animals; Central Nervous System; Cholinergic Fibers; GABA Antagonists

1987
GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat.
    Brain research, 1988, May-31, Volume: 450, Issue:1-2

    Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections;

1988
An antinociceptive profile of kojic amine: an analogue of gamma-aminobutyric acid (GABA).
    Neuropharmacology, 1987, Volume: 26, Issue:4

    Topics: Animals; Atropine; Atropine Derivatives; Baclofen; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice;

1987