Page last updated: 2024-10-29

ketanserin and Pain

ketanserin has been researched along with Pain in 38 studies

Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.

Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.

Research Excerpts

ExcerptRelevanceReference
"Ketanserin, a selective S2 serotonergic antagonist, was assessed against placebo in a double-blind cross-over study of 16 patients with chronic peripheral burning pain."9.06Ketanserin in reflex sympathetic dystrophy. A double-blind placebo controlled cross-over trial. ( Hanna, MH; Peat, SJ, 1989)
"Ketanserin, a selective S2 serotonergic antagonist, was assessed against placebo in a double-blind cross-over study of 16 patients with chronic peripheral burning pain."5.06Ketanserin in reflex sympathetic dystrophy. A double-blind placebo controlled cross-over trial. ( Hanna, MH; Peat, SJ, 1989)
"How can we treat patients with reduced morphine doses without loosing the pain killing effect or morphine antinociceptive effects (MAE)? To address this question, we hypothesized that serotonin (5-HT2) receptor antagonism could enhance MAE mediated by kappa-opioid receptors."3.77Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation. ( Climent, L; Horga, A; Horga, JF; Peiró, AM; Zapater, P, 2011)
"Paw skin incision is a well-established postoperative pain model that causes behavioral nociceptive responses and enhanced excitability of spinal dorsal horn neurons."1.36Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats. ( Del Bel, EA; Dias, QM; Prado, WA; Silveira, JW, 2010)
"Pretreatment with naloxone abolished this antinociceptive activity both in the hot-plate test and in the first phase of the formalin test without affecting the serum concentration of paracetamol."1.30Naloxone-reversible antinociception by paracetamol in the rat. ( Ottani, A; Pini, LA; Sandrini, M; Vitale, G, 1997)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19904 (10.53)18.7374
1990's14 (36.84)18.2507
2000's10 (26.32)29.6817
2010's9 (23.68)24.3611
2020's1 (2.63)2.80

Authors

AuthorsStudies
Liu, H1
Altenbach, RJ1
Carr, TL1
Chandran, P1
Hsieh, GC1
Lewis, LG1
Manelli, AM1
Milicic, I1
Marsh, KC1
Miller, TR1
Strakhova, MI1
Vortherms, TA1
Wakefield, BD1
Wetter, JM1
Witte, DG1
Honore, P1
Esbenshade, TA1
Brioni, JD1
Cowart, MD1
Valhondo, M1
Marco, I1
Martín-Fontecha, M1
Vázquez-Villa, H1
Ramos, JA1
Berkels, R1
Lauterbach, T1
Benhamú, B1
López-Rodríguez, ML1
Yuan, S1
Wang, N1
Yao, Y1
Liu, J1
Gao, M1
Mo, H1
Zhang, S1
Su, R1
Carrillo-Munguía, N1
González-Trujano, ME1
Huerta, M1
Trujillo, X1
Díaz-Reval, MI1
Huang, BQ1
Wu, B1
Hong, Y3
Hu, W1
Okazaki, R1
Namba, H1
Yoshida, H1
Okai, H1
Miura, T1
Kawamura, M1
Kupers, R1
Frokjaer, VG1
Naert, A1
Christensen, R1
Budtz-Joergensen, E1
Kehlet, H1
Knudsen, GM1
Wang, D1
Gao, Y1
Ji, H1
Silveira, JW1
Dias, QM1
Del Bel, EA1
Prado, WA1
Huang, J1
Fan, Y1
Jia, Y1
Rahman, W1
Bannister, K1
Bee, LA1
Dickenson, AH1
Peiró, AM1
Climent, L1
Zapater, P1
Horga, A1
Horga, JF1
Rani, S1
Gupta, MC1
de Luca, MC1
Brandão, ML3
Motta, VA1
Landeira-Fernandez, J1
Jürgensen, S1
Dalbó, S1
Angers, P1
Santos, AR1
Ribeiro-do-Valle, RM1
De Luca-Vinhas, MC1
Macedo, CE1
Dogrul, A1
Seyrek, M1
de Roose, J1
Symoens, J1
Takeshita, N1
Ohkubo, Y1
Yamaguchi, I1
Zhang, ZH1
Yang, SW1
Chen, JY1
Xie, YF1
Qiao, JT1
Dafny, N1
Laporte, AM1
Doyen, C1
Nevo, IT1
Chauveau, J1
Hauw, JJ1
Hamon, M1
Hemmeter, U1
Kocher, R1
Ladewig, D1
Hatzinger, M1
Seifritz, E1
Lauer, CJ1
Holsboer-Trachsler, E1
Pini, LA1
Vitale, G1
Ottani, A1
Sandrini, M1
Kjørsvik, A1
Størkson, R1
Tjølsen, A1
Hole, K1
Doak, GJ1
Sawynok, J1
Takagi, J1
Yonehara, N2
Ormazábal, MJ1
Goicoechea, C1
Alfaro, MJ1
Sánchez, E1
Martín, MI1
Ochi, T1
Goto, T1
Castilho, VM1
Neuman, RS1
Zebrowska, G1
Sufka, KJ1
Schomburg, FM1
Giordano, J2
Alhaider, AA1
Rosa, C1
Ghione, S1
Hanna, MH1
Peat, SJ1
el-Yassir, N1
Fleetwood-Walker, SM1
Mitchell, R1
Emmers, R1
Tamir, H1
Wilchek, M1

Trials

3 trials available for ketanserin and Pain

ArticleYear
Ketanserin in acute superficial thrombophlebitis.
    Lancet (London, England), 1982, Aug-21, Volume: 2, Issue:8295

    Topics: Acute Disease; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ketanseri

1982
[Sleep disorders in chronic pain and generalized tendomyopathy].
    Schweizerische medizinische Wochenschrift, 1995, Dec-09, Volume: 125, Issue:49

    Topics: Adult; Chronic Disease; Electroencephalography; Female; Fibromyalgia; Humans; Ketanserin; Male; Midd

1995
Ketanserin in reflex sympathetic dystrophy. A double-blind placebo controlled cross-over trial.
    Pain, 1989, Volume: 38, Issue:2

    Topics: Adult; Aged; Double-Blind Method; Female; Humans; Ketanserin; Male; Middle Aged; Pain; Placebos; Ref

1989

Other Studies

35 other studies available for ketanserin and Pain

ArticleYear
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
    Journal of medicinal chemistry, 2008, Nov-27, Volume: 51, Issue:22

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal;

2008
New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.
    Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20

    Topics: Analgesics; Animals; Binding, Competitive; Cyclic AMP; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP

2013
Role of 5-HT
    Neuroscience, 2022, Oct-15, Volume: 502

    Topics: Animals; Ketanserin; Mice; Pain; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptor, Serotonin,

2022
Tramadol and Tramadol+Caffeine Synergism in the Rat Formalin Test Are Mediated by Central Opioid and Serotonergic Mechanisms.
    BioMed research international, 2015, Volume: 2015

    Topics: Analgesics, Opioid; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Synergism; Ketanserin;

2015
[Effects of blockade of 5-HT2A receptors in inflammatory site on complete Freund's adjuvant-induced chronic hyperalgesia and neuropeptide Y expression in the spinal dorsal horn in rats].
    Sheng li xue bao : [Acta physiologica Sinica], 2015, Oct-25, Volume: 67, Issue:5

    Topics: Animals; Freund's Adjuvant; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Inflammation; Ketanserin

2015
The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:3

    Topics: Animals; Biological Products; GABA Antagonists; Injections, Spinal; Ketanserin; Lumbar Vertebrae; Mo

2008
A PET [18F]altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heat stimulation.
    NeuroImage, 2009, Feb-01, Volume: 44, Issue:3

    Topics: Adult; Binding Sites; Brain; Female; Fluorine Radioisotopes; Hot Temperature; Humans; Ketanserin; Ma

2009
Topical and systemic administrations of ketanserin attenuate hypersensitivity and expression of CGRP in rats with spinal nerve ligation.
    European journal of pharmacology, 2010, Feb-10, Volume: 627, Issue:1-3

    Topics: Administration, Topical; Animals; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Gene Expression

2010
Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats.
    Molecular pain, 2010, Mar-23, Volume: 6

    Topics: Animals; Atropine; Cholinergic Antagonists; Immunohistochemistry; Ketanserin; Male; Methiothepin; Me

2010
Antagonism of 5-HT(2A) receptors inhibits the expression of pronociceptive mediator and enhances endogenous opioid mechanism in carrageenan-induced inflammation in rats.
    European journal of pharmacology, 2011, Mar-01, Volume: 654, Issue:1

    Topics: Animals; beta-Endorphin; Calcitonin Gene-Related Peptide; Carrageenan; Ganglia, Spinal; Inflammation

2011
A pronociceptive role for the 5-HT2 receptor on spinal nociceptive transmission: an in vivo electrophysiological study in the rat.
    Brain research, 2011, Mar-25, Volume: 1382

    Topics: Action Potentials; Amphetamines; Animals; Evoked Potentials; Ketanserin; Male; Nerve Fibers, Unmyeli

2011
Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation.
    Pharmacological research, 2011, Volume: 64, Issue:1

    Topics: Adrenergic alpha-1 Receptor Antagonists; Analgesics; Animals; Dose-Response Relationship, Drug; Drug

2011
Evaluation and comparison of antinociceptive activity of aspartame with sucrose.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:2

    Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Aspartame; Disease Models, Animal; Ketanser

2012
Antinociception induced by stimulation of ventrolateral periaqueductal gray at the freezing threshold is regulated by opioid and 5-HT2A receptors as assessed by the tail-flick and formalin tests.
    Pharmacology, biochemistry, and behavior, 2003, Volume: 75, Issue:2

    Topics: Algorithms; Animals; Electric Stimulation; Formaldehyde; Ketanserin; Male; Microinjections; Naltrexo

2003
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
    Pharmacology, biochemistry, and behavior, 2005, Volume: 81, Issue:3

    Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Behavior, Animal; Capsaicin; Cat's Claw; Dose-

2005
Pharmacological assessment of the freezing, antinociception, and exploratory behavior organized in the ventrolateral periaqueductal gray.
    Pain, 2006, Volume: 121, Issue:1-2

    Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Behavior, Animal; Dose-Response Relationshi

2006
Systemic morphine produce antinociception mediated by spinal 5-HT7, but not 5-HT1A and 5-HT2 receptors in the spinal cord.
    British journal of pharmacology, 2006, Volume: 149, Issue:5

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Ketanserin; Male;

2006
Tiapride attenuates pain transmission through an indirect activation of central serotonergic mechanism.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1

    Topics: Animals; Central Nervous System; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dopamine An

1995
Interaction of serotonin and norepinephrine in spinal antinociception.
    Brain research bulletin, 1995, Volume: 38, Issue:2

    Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Electromyography

1995
Autoradiographic mapping of serotonin 5-HT1A, 5-HT1D, 5-HT2A and 5-HT3 receptors in the aged human spinal cord.
    Journal of chemical neuroanatomy, 1996, Volume: 11, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Aged, 80 and over; Aging; Autoradiography; Humans; Ket

1996
Naloxone-reversible antinociception by paracetamol in the rat.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2

    Topics: Acetaminophen; Animals; Cerebral Cortex; Formaldehyde; Hot Temperature; Ketanserin; Kinetics; Male;

1997
Differential effects of activation of lumbar and thoracic 5-HT2A/2C receptors on nociception in rats.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:3

    Topics: Amphetamines; Analysis of Variance; Animals; Excitatory Amino Acid Agonists; Injections, Spinal; Ket

1997
Formalin-induced nociceptive behavior and edema: involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes.
    Neuroscience, 1997, Volume: 80, Issue:3

    Topics: Animals; Edema; Formaldehyde; Indoles; Inflammation; Ketanserin; Male; Pain; Propranolol; Rats; Rats

1997
Serotonin receptor subtypes involved in modulation of electrical acupuncture.
    Japanese journal of pharmacology, 1998, Volume: 78, Issue:4

    Topics: Animals; Dental Pulp; Electric Stimulation; Electroacupuncture; Evoked Potentials; Indoles; Injectio

1998
Study of mechanisms of calcitonin analgesia in mice. Involvement of 5-HT3 receptors.
    Brain research, 1999, Oct-23, Volume: 845, Issue:2

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics; Animals; Brain Chemistry; Calcitonin; Dose-Respo

1999
The antinociceptive effect induced by FR140423 is mediated through spinal 5-HT2A and 5-HT3 receptors.
    European journal of pharmacology, 2000, Dec-08, Volume: 409, Issue:2

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Spi

2000
Influence of serotonin receptor antagonists on substance P and serotonin release evoked by tooth pulp stimulation with electro-acupuncture in the trigeminal nucleus cudalis of the rabbit.
    Neuroscience research, 2001, Volume: 40, Issue:1

    Topics: Afferent Pathways; Animals; Dental Pulp Cavity; Electric Stimulation; Electroacupuncture; Indoles; K

2001
Conditioned antinociception and freezing using electrical stimulation of the dorsal periaqueductal gray or inferior colliculus as unconditioned stimulus are differentially regulated by 5-HT2A receptors in rats.
    Psychopharmacology, 2001, Volume: 155, Issue:2

    Topics: Animals; Autonomic Nervous System; Avoidance Learning; Behavior, Animal; Conditioning, Psychological

2001
Serotonin (5-HT2) receptor mediated enhancement of cortical unit activity.
    Canadian journal of physiology and pharmacology, 1992, Volume: 70, Issue:12

    Topics: Animals; Cerebral Cortex; Cinanserin; Cyproheptadine; Iontophoresis; Ketanserin; Male; Microelectrod

1992
Receptor mediation of 5-HT-induced inflammation and nociception in rats.
    Pharmacology, biochemistry, and behavior, 1992, Volume: 41, Issue:1

    Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Imidazoles; Inflammation; Ketanserin; M

1992
Antinociceptive effect of ketanserin in mice: involvement of supraspinal 5-HT2 receptors in nociceptive transmission.
    Brain research, 1991, Mar-15, Volume: 543, Issue:2

    Topics: Acetates; Acetic Acid; Adrenergic alpha-Antagonists; Analgesics; Animals; Brain Chemistry; Dioxanes;

1991
Analgesic profile of centrally administered 2-methylserotonin against acute pain in rats.
    European journal of pharmacology, 1991, Jun-25, Volume: 199, Issue:2

    Topics: Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Injections, Intraventricular; In

1991
Effect of ketanserin on pain perception in arterial hypertension.
    Cardiovascular drugs and therapy, 1990, Volume: 4 Suppl 1

    Topics: Adult; Blood Pressure; Dental Pulp; Electric Stimulation; Female; Humans; Hypertension; Ketanserin;

1990
Heterogeneous effects of serotonin in the dorsal horn of rat: the involvement of 5-HT1 receptor subtypes.
    Brain research, 1988, Jul-19, Volume: 456, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Indoles; Ketanserin; Male; Neuro

1988
Influence of a serotonin receptor antagonist, 5-HTP-DP-hex, on spinal and thalamic nociceptive neurons in rats.
    Experimental neurology, 1987, Volume: 96, Issue:3

    Topics: 5-Hydroxytryptophan; Action Potentials; Animals; Ketanserin; Male; Methysergide; Naloxone; Nerve Fib

1987