ketanserin and Pain
ketanserin has been researched along with Pain in 38 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketanserin, a selective S2 serotonergic antagonist, was assessed against placebo in a double-blind cross-over study of 16 patients with chronic peripheral burning pain." | 9.06 | Ketanserin in reflex sympathetic dystrophy. A double-blind placebo controlled cross-over trial. ( Hanna, MH; Peat, SJ, 1989) |
| "Ketanserin, a selective S2 serotonergic antagonist, was assessed against placebo in a double-blind cross-over study of 16 patients with chronic peripheral burning pain." | 5.06 | Ketanserin in reflex sympathetic dystrophy. A double-blind placebo controlled cross-over trial. ( Hanna, MH; Peat, SJ, 1989) |
| "How can we treat patients with reduced morphine doses without loosing the pain killing effect or morphine antinociceptive effects (MAE)? To address this question, we hypothesized that serotonin (5-HT2) receptor antagonism could enhance MAE mediated by kappa-opioid receptors." | 3.77 | Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation. ( Climent, L; Horga, A; Horga, JF; Peiró, AM; Zapater, P, 2011) |
| "Paw skin incision is a well-established postoperative pain model that causes behavioral nociceptive responses and enhanced excitability of spinal dorsal horn neurons." | 1.36 | Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats. ( Del Bel, EA; Dias, QM; Prado, WA; Silveira, JW, 2010) |
| "Pretreatment with naloxone abolished this antinociceptive activity both in the hot-plate test and in the first phase of the formalin test without affecting the serum concentration of paracetamol." | 1.30 | Naloxone-reversible antinociception by paracetamol in the rat. ( Ottani, A; Pini, LA; Sandrini, M; Vitale, G, 1997) |
Research
Studies (38)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (10.53) | 18.7374 |
| 1990's | 14 (36.84) | 18.2507 |
| 2000's | 10 (26.32) | 29.6817 |
| 2010's | 9 (23.68) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Altenbach, RJ | 1 |
| Carr, TL | 1 |
| Chandran, P | 1 |
| Hsieh, GC | 1 |
| Lewis, LG | 1 |
| Manelli, AM | 1 |
| Milicic, I | 1 |
| Marsh, KC | 1 |
| Miller, TR | 1 |
| Strakhova, MI | 1 |
| Vortherms, TA | 1 |
| Wakefield, BD | 1 |
| Wetter, JM | 1 |
| Witte, DG | 1 |
| Honore, P | 1 |
| Esbenshade, TA | 1 |
| Brioni, JD | 1 |
| Cowart, MD | 1 |
| Valhondo, M | 1 |
| Marco, I | 1 |
| Martín-Fontecha, M | 1 |
| Vázquez-Villa, H | 1 |
| Ramos, JA | 1 |
| Berkels, R | 1 |
| Lauterbach, T | 1 |
| Benhamú, B | 1 |
| López-Rodríguez, ML | 1 |
| Yuan, S | 1 |
| Wang, N | 1 |
| Yao, Y | 1 |
| Liu, J | 1 |
| Gao, M | 1 |
| Mo, H | 1 |
| Zhang, S | 1 |
| Su, R | 1 |
| Carrillo-Munguía, N | 1 |
| González-Trujano, ME | 1 |
| Huerta, M | 1 |
| Trujillo, X | 1 |
| Díaz-Reval, MI | 1 |
| Huang, BQ | 1 |
| Wu, B | 1 |
| Hong, Y | 3 |
| Hu, W | 1 |
| Okazaki, R | 1 |
| Namba, H | 1 |
| Yoshida, H | 1 |
| Okai, H | 1 |
| Miura, T | 1 |
| Kawamura, M | 1 |
| Kupers, R | 1 |
| Frokjaer, VG | 1 |
| Naert, A | 1 |
| Christensen, R | 1 |
| Budtz-Joergensen, E | 1 |
| Kehlet, H | 1 |
| Knudsen, GM | 1 |
| Wang, D | 1 |
| Gao, Y | 1 |
| Ji, H | 1 |
| Silveira, JW | 1 |
| Dias, QM | 1 |
| Del Bel, EA | 1 |
| Prado, WA | 1 |
| Huang, J | 1 |
| Fan, Y | 1 |
| Jia, Y | 1 |
| Rahman, W | 1 |
| Bannister, K | 1 |
| Bee, LA | 1 |
| Dickenson, AH | 1 |
| Peiró, AM | 1 |
| Climent, L | 1 |
| Zapater, P | 1 |
| Horga, A | 1 |
| Horga, JF | 1 |
| Rani, S | 1 |
| Gupta, MC | 1 |
| de Luca, MC | 1 |
| Brandão, ML | 3 |
| Motta, VA | 1 |
| Landeira-Fernandez, J | 1 |
| Jürgensen, S | 1 |
| Dalbó, S | 1 |
| Angers, P | 1 |
| Santos, AR | 1 |
| Ribeiro-do-Valle, RM | 1 |
| De Luca-Vinhas, MC | 1 |
| Macedo, CE | 1 |
| Dogrul, A | 1 |
| Seyrek, M | 1 |
| de Roose, J | 1 |
| Symoens, J | 1 |
| Takeshita, N | 1 |
| Ohkubo, Y | 1 |
| Yamaguchi, I | 1 |
| Zhang, ZH | 1 |
| Yang, SW | 1 |
| Chen, JY | 1 |
| Xie, YF | 1 |
| Qiao, JT | 1 |
| Dafny, N | 1 |
| Laporte, AM | 1 |
| Doyen, C | 1 |
| Nevo, IT | 1 |
| Chauveau, J | 1 |
| Hauw, JJ | 1 |
| Hamon, M | 1 |
| Hemmeter, U | 1 |
| Kocher, R | 1 |
| Ladewig, D | 1 |
| Hatzinger, M | 1 |
| Seifritz, E | 1 |
| Lauer, CJ | 1 |
| Holsboer-Trachsler, E | 1 |
| Pini, LA | 1 |
| Vitale, G | 1 |
| Ottani, A | 1 |
| Sandrini, M | 1 |
| Kjørsvik, A | 1 |
| Størkson, R | 1 |
| Tjølsen, A | 1 |
| Hole, K | 1 |
| Doak, GJ | 1 |
| Sawynok, J | 1 |
| Takagi, J | 1 |
| Yonehara, N | 2 |
| Ormazábal, MJ | 1 |
| Goicoechea, C | 1 |
| Alfaro, MJ | 1 |
| Sánchez, E | 1 |
| Martín, MI | 1 |
| Ochi, T | 1 |
| Goto, T | 1 |
| Castilho, VM | 1 |
| Neuman, RS | 1 |
| Zebrowska, G | 1 |
| Sufka, KJ | 1 |
| Schomburg, FM | 1 |
| Giordano, J | 2 |
| Alhaider, AA | 1 |
| Rosa, C | 1 |
| Ghione, S | 1 |
| Hanna, MH | 1 |
| Peat, SJ | 1 |
| el-Yassir, N | 1 |
| Fleetwood-Walker, SM | 1 |
| Mitchell, R | 1 |
| Emmers, R | 1 |
| Tamir, H | 1 |
| Wilchek, M | 1 |
Trials
3 trials available for ketanserin and Pain
| Article | Year |
|---|---|
Ketanserin in acute superficial thrombophlebitis.
Topics: Acute Disease; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ketanseri | 1982 |
[Sleep disorders in chronic pain and generalized tendomyopathy].
Topics: Adult; Chronic Disease; Electroencephalography; Female; Fibromyalgia; Humans; Ketanserin; Male; Midd | 1995 |
Ketanserin in reflex sympathetic dystrophy. A double-blind placebo controlled cross-over trial.
Topics: Adult; Aged; Double-Blind Method; Female; Humans; Ketanserin; Male; Middle Aged; Pain; Placebos; Ref | 1989 |
Other Studies
35 other studies available for ketanserin and Pain
| Article | Year |
|---|---|
cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzofurans; Carrageenan; Disease Models, Animal; | 2008 |
New serotonin 5-HT1A receptor agonists endowed with antinociceptive activity in vivo.
Topics: Analgesics; Animals; Binding, Competitive; Cyclic AMP; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP | 2013 |
Role of 5-HT
Topics: Animals; Ketanserin; Mice; Pain; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, | 2022 |
Tramadol and Tramadol+Caffeine Synergism in the Rat Formalin Test Are Mediated by Central Opioid and Serotonergic Mechanisms.
Topics: Analgesics, Opioid; Animals; Caffeine; Dose-Response Relationship, Drug; Drug Synergism; Ketanserin; | 2015 |
[Effects of blockade of 5-HT2A receptors in inflammatory site on complete Freund's adjuvant-induced chronic hyperalgesia and neuropeptide Y expression in the spinal dorsal horn in rats].
Topics: Animals; Freund's Adjuvant; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Inflammation; Ketanserin | 2015 |
The antiallodynic effect of Neurotropin is mediated via activation of descending pain inhibitory systems in rats with spinal nerve ligation.
Topics: Animals; Biological Products; GABA Antagonists; Injections, Spinal; Ketanserin; Lumbar Vertebrae; Mo | 2008 |
A PET [18F]altanserin study of 5-HT2A receptor binding in the human brain and responses to painful heat stimulation.
Topics: Adult; Binding Sites; Brain; Female; Fluorine Radioisotopes; Hot Temperature; Humans; Ketanserin; Ma | 2009 |
Topical and systemic administrations of ketanserin attenuate hypersensitivity and expression of CGRP in rats with spinal nerve ligation.
Topics: Administration, Topical; Animals; Calcitonin Gene-Related Peptide; Ganglia, Spinal; Gene Expression | 2010 |
Serotonin receptors are involved in the spinal mediation of descending facilitation of surgical incision-induced increase of Fos-like immunoreactivity in rats.
Topics: Animals; Atropine; Cholinergic Antagonists; Immunohistochemistry; Ketanserin; Male; Methiothepin; Me | 2010 |
Antagonism of 5-HT(2A) receptors inhibits the expression of pronociceptive mediator and enhances endogenous opioid mechanism in carrageenan-induced inflammation in rats.
Topics: Animals; beta-Endorphin; Calcitonin Gene-Related Peptide; Carrageenan; Ganglia, Spinal; Inflammation | 2011 |
A pronociceptive role for the 5-HT2 receptor on spinal nociceptive transmission: an in vivo electrophysiological study in the rat.
Topics: Action Potentials; Amphetamines; Animals; Evoked Potentials; Ketanserin; Male; Nerve Fibers, Unmyeli | 2011 |
Ketanserin potentiates morphine-induced antinociception mediated by kappa-receptor activation.
Topics: Adrenergic alpha-1 Receptor Antagonists; Analgesics; Animals; Dose-Response Relationship, Drug; Drug | 2011 |
Evaluation and comparison of antinociceptive activity of aspartame with sucrose.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Aspartame; Disease Models, Animal; Ketanser | 2012 |
Antinociception induced by stimulation of ventrolateral periaqueductal gray at the freezing threshold is regulated by opioid and 5-HT2A receptors as assessed by the tail-flick and formalin tests.
Topics: Algorithms; Animals; Electric Stimulation; Formaldehyde; Ketanserin; Male; Microinjections; Naltrexo | 2003 |
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Behavior, Animal; Capsaicin; Cat's Claw; Dose- | 2005 |
Pharmacological assessment of the freezing, antinociception, and exploratory behavior organized in the ventrolateral periaqueductal gray.
Topics: Analysis of Variance; Anesthetics, Intravenous; Animals; Behavior, Animal; Dose-Response Relationshi | 2006 |
Systemic morphine produce antinociception mediated by spinal 5-HT7, but not 5-HT1A and 5-HT2 receptors in the spinal cord.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Injections, Spinal; Ketanserin; Male; | 2006 |
Tiapride attenuates pain transmission through an indirect activation of central serotonergic mechanism.
Topics: Animals; Central Nervous System; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dopamine An | 1995 |
Interaction of serotonin and norepinephrine in spinal antinociception.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Interactions; Electromyography | 1995 |
Autoradiographic mapping of serotonin 5-HT1A, 5-HT1D, 5-HT2A and 5-HT3 receptors in the aged human spinal cord.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aged; Aged, 80 and over; Aging; Autoradiography; Humans; Ket | 1996 |
Naloxone-reversible antinociception by paracetamol in the rat.
Topics: Acetaminophen; Animals; Cerebral Cortex; Formaldehyde; Hot Temperature; Ketanserin; Kinetics; Male; | 1997 |
Differential effects of activation of lumbar and thoracic 5-HT2A/2C receptors on nociception in rats.
Topics: Amphetamines; Analysis of Variance; Animals; Excitatory Amino Acid Agonists; Injections, Spinal; Ket | 1997 |
Formalin-induced nociceptive behavior and edema: involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes.
Topics: Animals; Edema; Formaldehyde; Indoles; Inflammation; Ketanserin; Male; Pain; Propranolol; Rats; Rats | 1997 |
Serotonin receptor subtypes involved in modulation of electrical acupuncture.
Topics: Animals; Dental Pulp; Electric Stimulation; Electroacupuncture; Evoked Potentials; Indoles; Injectio | 1998 |
Study of mechanisms of calcitonin analgesia in mice. Involvement of 5-HT3 receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics; Animals; Brain Chemistry; Calcitonin; Dose-Respo | 1999 |
The antinociceptive effect induced by FR140423 is mediated through spinal 5-HT2A and 5-HT3 receptors.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Injections, Spi | 2000 |
Influence of serotonin receptor antagonists on substance P and serotonin release evoked by tooth pulp stimulation with electro-acupuncture in the trigeminal nucleus cudalis of the rabbit.
Topics: Afferent Pathways; Animals; Dental Pulp Cavity; Electric Stimulation; Electroacupuncture; Indoles; K | 2001 |
Conditioned antinociception and freezing using electrical stimulation of the dorsal periaqueductal gray or inferior colliculus as unconditioned stimulus are differentially regulated by 5-HT2A receptors in rats.
Topics: Animals; Autonomic Nervous System; Avoidance Learning; Behavior, Animal; Conditioning, Psychological | 2001 |
Serotonin (5-HT2) receptor mediated enhancement of cortical unit activity.
Topics: Animals; Cerebral Cortex; Cinanserin; Cyproheptadine; Iontophoresis; Ketanserin; Male; Microelectrod | 1992 |
Receptor mediation of 5-HT-induced inflammation and nociception in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Imidazoles; Inflammation; Ketanserin; M | 1992 |
Antinociceptive effect of ketanserin in mice: involvement of supraspinal 5-HT2 receptors in nociceptive transmission.
Topics: Acetates; Acetic Acid; Adrenergic alpha-Antagonists; Analgesics; Animals; Brain Chemistry; Dioxanes; | 1991 |
Analgesic profile of centrally administered 2-methylserotonin against acute pain in rats.
Topics: Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Injections, Intraventricular; In | 1991 |
Effect of ketanserin on pain perception in arterial hypertension.
Topics: Adult; Blood Pressure; Dental Pulp; Electric Stimulation; Female; Humans; Hypertension; Ketanserin; | 1990 |
Heterogeneous effects of serotonin in the dorsal horn of rat: the involvement of 5-HT1 receptor subtypes.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Action Potentials; Animals; Indoles; Ketanserin; Male; Neuro | 1988 |
Influence of a serotonin receptor antagonist, 5-HTP-DP-hex, on spinal and thalamic nociceptive neurons in rats.
Topics: 5-Hydroxytryptophan; Action Potentials; Animals; Ketanserin; Male; Methysergide; Naloxone; Nerve Fib | 1987 |