metronidazole has been researched along with Gastroesophageal Reflux in 18 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We used data from a randomized placebo-controlled clinical trial to examine the relationship between Helicobacter pylori and reflux symptoms in nonulcer dyspepsia patients randomly assigned anti-Helicobacter pylori triple therapy alone, calcium carbonate alone, or in combination with triple therapy, tetracycline, or placebo." | 5.10 | Increased reflux symptoms after calcium carbonate supplementation and successful anti-Helicobacter pylori treatment. ( Correa, P; Feldman, M; Fischbach, LA; Fontham, E; Goodman, KJ; Jain, R; Priest, E, 2003) |
| "We therefore assessed the incidence of GERD among comparable patients having undergone successful versus failed H." | 2.69 | Is Helicobacter pylori eradication associated with gastroesophageal reflux disease? ( Barkun, AN; Beech, R; Best, L; Fallone, CA; Friedman, G; Joseph, L; Loo, V; Mayrand, S, 2000) |
| "Incidence rates of Barrett's esophagus and adenocarcinoma in each group were evaluated by histological analysis." | 1.43 | Alteration of Esophageal Microbiome by Antibiotic Treatment Does Not Affect Incidence of Rat Esophageal Adenocarcinoma. ( Arakawa, T; Fujiwara, Y; Gi, M; Nagami, Y; Sawada, A; Shiba, M; Tanaka, F; Tanigawa, T; Tominaga, K; Wanibuchi, H; Watanabe, T; Yamagami, H, 2016) |
| "Emphysematous gastritis is a rare form of gastritis characterized by gaseous dissection of the stomach wall usually secondary to invasion by gas forming organisms, corrosive ingestion, trauma, or gastric infarction." | 1.37 | Emphysematous gastritis associated with ulcerative esophagitis. ( Abbass, K; Akram, S; Hassan, S; Markert, R, 2011) |
| "Pre-existing nonerosive gastroesophageal reflux disease, smoking, and older age are important predictors of de novo development of erosive esophagitis." | 1.36 | De novo erosive esophagitis in duodenal ulcer patients related to pre-existing reflux symptoms, smoking, and patient age, but not to Helicobacter pylori eradication: a one-year follow-up study. ( Jonaitis, L; Kiudelis, G; Kupčinskas, J; Kupčinskas, L, 2010) |
| "pylori induces de novo GERD symptoms in ulcer patients." | 1.31 | Symptomatic benefit 1-3 years after H. pylori eradication in ulcer patients: impact of gastroesophageal reflux disease. ( Dickson, A; El-Nujumi, A; El-Omar, E; Kelman, A; McColl, KE, 2000) |
| "All patients had abnormal gastro-oesophageal reflux before anti-H." | 1.30 | The effect of Helicobacter pylori eradication on gastro-oesophageal reflux. ( Berstad, A; Hatlebakk, JG; Tefera, S, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, SG | 1 |
| Jung, HK | 1 |
| Lee, HL | 1 |
| Jang, JY | 1 |
| Lee, H | 1 |
| Kim, CG | 1 |
| Shin, WG | 1 |
| Shin, ES | 1 |
| Lee, YC | 1 |
| Chung, KH | 1 |
| Lee, DH | 1 |
| Jin, E | 1 |
| Cho, Y | 1 |
| Seo, JY | 1 |
| Kim, N | 1 |
| Jeong, SH | 1 |
| Kim, JW | 1 |
| Hwang, JH | 1 |
| Shin, CM | 1 |
| Zagari, RM | 1 |
| Romano, M | 1 |
| Ojetti, V | 1 |
| Stockbrugger, R | 1 |
| Gullini, S | 1 |
| Annibale, B | 1 |
| Farinati, F | 1 |
| Ierardi, E | 1 |
| Maconi, G | 1 |
| Rugge, M | 2 |
| Calabrese, C | 1 |
| Di Mario, F | 1 |
| Luzza, F | 1 |
| Pretolani, S | 1 |
| Savio, A | 1 |
| Gasbarrini, G | 1 |
| Caselli, M | 1 |
| Sawada, A | 1 |
| Fujiwara, Y | 1 |
| Nagami, Y | 1 |
| Tanaka, F | 1 |
| Yamagami, H | 1 |
| Tanigawa, T | 1 |
| Shiba, M | 1 |
| Tominaga, K | 1 |
| Watanabe, T | 1 |
| Gi, M | 1 |
| Wanibuchi, H | 1 |
| Arakawa, T | 1 |
| Jonaitis, L | 1 |
| Kupčinskas, J | 1 |
| Kiudelis, G | 1 |
| Kupčinskas, L | 1 |
| Hassan, S | 1 |
| Abbass, K | 1 |
| Markert, R | 1 |
| Akram, S | 1 |
| Schuster, MJ | 1 |
| Patel, JC | 1 |
| Shastikar, YV | 1 |
| Fischbach, LA | 1 |
| Correa, P | 1 |
| Feldman, M | 1 |
| Fontham, E | 1 |
| Priest, E | 1 |
| Goodman, KJ | 1 |
| Jain, R | 1 |
| Barbato, A | 1 |
| Panizzolo, C | 1 |
| Landi, L | 1 |
| Semenzato, R | 1 |
| Malfertheiner, P | 1 |
| Dzieniszewski, J | 1 |
| Jarosz, M | 1 |
| Lygren, I | 1 |
| Andersen, LP | 1 |
| Lerang, F | 1 |
| Kleveland, PM | 1 |
| Farup, P | 1 |
| Vatn, M | 1 |
| Aursnes, I | 1 |
| Kuipers, EJ | 1 |
| Klinkenberg-Knol, EC | 1 |
| Tefera, S | 1 |
| Hatlebakk, JG | 1 |
| Berstad, A | 1 |
| McColl, KE | 1 |
| Dickson, A | 1 |
| El-Nujumi, A | 1 |
| El-Omar, E | 1 |
| Kelman, A | 1 |
| Fallone, CA | 1 |
| Barkun, AN | 1 |
| Friedman, G | 1 |
| Mayrand, S | 1 |
| Loo, V | 1 |
| Beech, R | 1 |
| Best, L | 1 |
| Joseph, L | 1 |
| Maev, IV | 1 |
| V'iuchnova, ES | 1 |
| Lebedev, EG | 1 |
| Dicheva, DT | 1 |
| Ovsiannikova, EV | 1 |
| Antonenko, OM | 1 |
| Shchekina, MI | 1 |
4 reviews available for metronidazole and Gastroesophageal Reflux
| Article | Year |
|---|---|
[Helicobacter pylori. Update 2002].
Topics: Adenocarcinoma; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Drug Therapy, Combination; Duode | 2002 |
[Guidelines for the diagnosis and treatment of H. pylori infection].
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Drug Therapy, Combination; Duodenal Ulcer; Dysp | 2003 |
Helicobacter pylori, acid, and omeprazole revisited: bacterial eradication and rebound hypersecretion.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Gastric Acid; Gastroesophagea | 1999 |
[Experience in the use of losek (omeprazole) in gastroenterology].
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Ulcer Agents; Clarithromycin; Double | 2001 |
2 trials available for metronidazole and Gastroesophageal Reflux
| Article | Year |
|---|---|
Increased reflux symptoms after calcium carbonate supplementation and successful anti-Helicobacter pylori treatment.
Topics: Adult; Amoxicillin; Antacids; Bismuth; Calcium Carbonate; Drug Therapy, Combination; Dyspepsia; Fema | 2003 |
Is Helicobacter pylori eradication associated with gastroesophageal reflux disease?
Topics: Adolescent; Adult; Aged; Amoxicillin; Anti-Ulcer Agents; Bismuth; Double-Blind Method; Drug Therapy, | 2000 |
12 other studies available for metronidazole and Gastroesophageal Reflux
| Article | Year |
|---|---|
[Guidelines for the diagnosis and treatment of Helicobacter pylori infection in Korea, 2013 revised edition].
Topics: Amoxicillin; Anti-Bacterial Agents; Aspirin; Bismuth; Breath Tests; Clarithromycin; Gastroesophageal | 2013 |
The efficacy of moxifloxacin-containing triple therapy after standard triple, sequential, or concomitant therapy failure for Helicobacter pylori eradication in Korea.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Breath Tests; Cohort Studies; Drug Ther | 2014 |
Guidelines for the management of Helicobacter pylori infection in Italy: The III Working Group Consensus Report 2015.
Topics: Amoxicillin; Antacids; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Bac | 2015 |
Alteration of Esophageal Microbiome by Antibiotic Treatment Does Not Affect Incidence of Rat Esophageal Adenocarcinoma.
Topics: Adenocarcinoma; Ampicillin; Anastomosis, Surgical; Animals; Anti-Bacterial Agents; Barrett Esophagus | 2016 |
De novo erosive esophagitis in duodenal ulcer patients related to pre-existing reflux symptoms, smoking, and patient age, but not to Helicobacter pylori eradication: a one-year follow-up study.
Topics: Adult; Age Factors; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Ulcer Agents; Cl | 2010 |
Emphysematous gastritis associated with ulcerative esophagitis.
Topics: Aged; Anti-Bacterial Agents; Bacterial Infections; Ciprofloxacin; Diabetes Mellitus, Type 2; Emphyse | 2011 |
GERD like symptoms as seen in a village.
Topics: Adolescent; Adult; Animals; Antacids; Comorbidity; Diagnosis, Differential; Disease Outbreaks; Endem | 2002 |
Asthma-like syndrome in a teenager.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Albuterol; Amoxicillin; Androstadienes; Anti-Ba | 2003 |
Guidelines in the medical treatment of Helicobacter pylori infection.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Clarithromycin; Dyspeps | 2006 |
[Treatment of Helicobacter pylori infection].
Topics: Antacids; Anti-Bacterial Agents; Clarithromycin; Dyspepsia; Gastroesophageal Reflux; Helicobacter In | 1998 |
The effect of Helicobacter pylori eradication on gastro-oesophageal reflux.
Topics: Adult; Aged; Antacids; Anti-Bacterial Agents; Bismuth; Breath Tests; Drug Therapy, Combination; Esop | 1999 |
Symptomatic benefit 1-3 years after H. pylori eradication in ulcer patients: impact of gastroesophageal reflux disease.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Drug Therapy, Combination; Femal | 2000 |