metronidazole has been researched along with Malignant Melanoma in 8 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The radiosensitizing effect of two electron-affinic nitroimidazoles, metronidazole and misonidazole (Ro-07-0582), has been tested on a human malignant melanoma grown subcutaneously in the athymic mutant nude mouse." | 7.66 | The radiosensitizing effect of metronidazole and misonidazole (Ro-07-0582) on a human malignant melanoma grown in the athymic mutant nude mouse. ( Brustad, T; Rofstad, EK, 1978) |
| "The radiosensitizing effect of two electron-affinic nitroimidazoles, metronidazole and misonidazole (Ro-07-0582), has been tested on a human malignant melanoma grown subcutaneously in the athymic mutant nude mouse." | 3.66 | The radiosensitizing effect of metronidazole and misonidazole (Ro-07-0582) on a human malignant melanoma grown in the athymic mutant nude mouse. ( Brustad, T; Rofstad, EK, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Karakulov, RK | 1 |
| Konradov, AA | 1 |
| Pelevina, II | 1 |
| Munzenrider, JE | 1 |
| White, RA | 1 |
| Lowe, RJ | 1 |
| Carwardine, PC | 1 |
| Ingham, A | 1 |
| Rofstad, EK | 1 |
| Brustad, T | 1 |
| Kudriavtseva, GT | 1 |
| Khmelevskaia, ZI | 1 |
| Iliukhin, SA | 1 |
| Neborak, IuT | 1 |
| Grigor'ev, AN | 1 |
| Lönn, U | 1 |
| Lönn, S | 1 |
1 review available for metronidazole and Malignant Melanoma
| Article | Year |
|---|---|
Recent advances in radiotherapy.
Topics: Breast Neoplasms; Bromodeoxyuridine; Carcinoid Tumor; Elementary Particles; Fast Neutrons; Hot Tempe | 1977 |
7 other studies available for metronidazole and Malignant Melanoma
| Article | Year |
|---|---|
[Effect of metronidazole on the radiation reaction of transplanted tumors].
Topics: Animals; Cell Division; Cell Survival; Melanoma; Metronidazole; Mice; Models, Biological; Neoplasms, | 1983 |
Metronidazole and melanoma.
Topics: Animals; Dog Diseases; Dogs; Melanoma; Metronidazole | 1978 |
Metronidazole and melanoma.
Topics: Animals; Dog Diseases; Dogs; Melanoma; Metronidazole | 1978 |
Metronidazole and melanoma.
Topics: Animals; Dog Diseases; Dogs; Melanoma; Metronidazole | 1978 |
The radiosensitizing effect of metronidazole and misonidazole (Ro-07-0582) on a human malignant melanoma grown in the athymic mutant nude mouse.
Topics: Animals; Humans; Melanoma; Metronidazole; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Exp | 1978 |
[Metronidazole in the combined treatment of malignant melanoma of the skin].
Topics: Adult; Aged; Combined Modality Therapy; Female; Humans; Male; Melanoma; Metronidazole; Middle Aged; | 1989 |
Treatment with dilute alkali-nuclease S1 permits the analysis of DNA damage: cells treated with platinum analogues.
Topics: Cell Line; Cisplatin; Cytarabine; DNA Damage; DNA Replication; DNA, Neoplasm; Endonucleases; Humans; | 1987 |