metronidazole has been researched along with Skin Neoplasms in 15 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Skin Neoplasms: Tumors or cancer of the SKIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole 0." | 2.82 | Safe and effective deodorization of malodorous fungating tumors using topical metronidazole 0.75 % gel (GK567): a multicenter, open-label, phase III study (RDT.07.SRE.27013). ( Ikoma, A; Miyai, E; Nakamura, S; Shimo, A; Takemura, K; Tokuda, Y; Tsugawa, K; Watanabe, K; Yamauchi, H, 2016) |
| "The patient received treatment with anti-tetanus globulin and metronidazole; sound insulation and shielding were also performed in a dark room." | 2.72 | Non-surgical treatment of tetanus infection associated with breast cancer skin ulcer: a case report and literature review. ( Aisaka, W; Narimatsu, E; Nomura, K; Okamoto, H; Sakawaki, E; Sakawaki, S; Takeyama, Y; Uemura, S; Yamaoka, A, 2021) |
| "Fungating wounds arise from primary, secondary or recurrent malignant disease and are associated with advanced cancer." | 2.50 | Topical agents and dressings for fungating wounds. ( Adderley, UJ; Holt, IG, 2014) |
| "Fungating wounds arise from primary, secondary or recurrent malignant disease and are associated with advanced cancer." | 2.44 | Topical agents and dressings for fungating wounds. ( Adderley, U; Smith, R, 2007) |
| "Fingating wounds always present a management challenge." | 2.43 | Assessment and management of fungating wounds: a review. ( Wilson, V, 2005) |
| "He had had recent chemotherapy for Merkel cell carcinoma of the right ear." | 1.34 | Use of intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis. ( Hassoun, A; Ibrahim, F, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (26.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 4 (26.67) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Nomura, K | 1 |
| Sakawaki, E | 1 |
| Sakawaki, S | 1 |
| Yamaoka, A | 1 |
| Aisaka, W | 1 |
| Okamoto, H | 1 |
| Takeyama, Y | 1 |
| Uemura, S | 1 |
| Narimatsu, E | 1 |
| Desai, A | 1 |
| Krishnan, A | 1 |
| Zaghloul, A | 1 |
| McClure, M | 1 |
| Adderley, UJ | 1 |
| Holt, IG | 1 |
| Watanabe, K | 1 |
| Shimo, A | 1 |
| Tsugawa, K | 1 |
| Tokuda, Y | 1 |
| Yamauchi, H | 1 |
| Miyai, E | 1 |
| Takemura, K | 1 |
| Ikoma, A | 1 |
| Nakamura, S | 1 |
| Madsen, JT | 1 |
| Lorentzen, HF | 1 |
| Paulsen, E | 1 |
| Rosmaninho, A | 1 |
| Alves, R | 1 |
| Lima, M | 1 |
| Lobo, I | 1 |
| Amorim, I | 1 |
| Selores, M | 1 |
| Wilson, V | 1 |
| Adderley, U | 1 |
| Smith, R | 1 |
| Hassoun, A | 1 |
| Ibrahim, F | 1 |
| Lo, SF | 1 |
| Hsu, MY | 1 |
| Hu, WY | 1 |
| Urtasun, RC | 1 |
| Band, P | 1 |
| Ferri, H | 1 |
| Clark, J | 1 |
| Brückner, V | 1 |
| Peters, LJ | 1 |
| Kudriavtseva, GT | 1 |
| Khmelevskaia, ZI | 1 |
| Iliukhin, SA | 1 |
| Neborak, IuT | 1 |
| Grigor'ev, AN | 1 |
5 reviews available for metronidazole and Skin Neoplasms
| Article | Year |
|---|---|
Non-surgical treatment of tetanus infection associated with breast cancer skin ulcer: a case report and literature review.
Topics: Breast Neoplasms; Female; Humans; Lymphatic Metastasis; Metronidazole; Middle Aged; Neoplasm Recurre | 2021 |
Topical agents and dressings for fungating wounds.
Topics: Anti-Infective Agents, Local; Antineoplastic Agents; Biological Dressings; Disease Progression; Fema | 2014 |
Assessment and management of fungating wounds: a review.
Topics: Administration, Topical; Alginates; Anti-Infective Agents; Bandages; Charcoal; Community Health Nurs | 2005 |
Topical agents and dressings for fungating wounds.
Topics: Anti-Infective Agents, Local; Antineoplastic Agents; Biological Dressings; Disease Progression; Fema | 2007 |
Using wound bed preparation to heal a malignant fungating wound: a single case study.
Topics: Adult; Bandages, Hydrocolloid; Breast Neoplasms; Carboxymethylcellulose Sodium; Clinical Protocols; | 2007 |
1 trial available for metronidazole and Skin Neoplasms
| Article | Year |
|---|---|
Safe and effective deodorization of malodorous fungating tumors using topical metronidazole 0.75 % gel (GK567): a multicenter, open-label, phase III study (RDT.07.SRE.27013).
Topics: Administration, Cutaneous; Adult; Aged; Anti-Infective Agents; Bacterial Infections; Female; Humans; | 2016 |
9 other studies available for metronidazole and Skin Neoplasms
| Article | Year |
|---|---|
Calvarial osteomyelitis and intracranial extension post-Mohs micrographic surgery.
Topics: Aged; Anti-Bacterial Agents; Carcinoma, Basal Cell; Diagnosis, Differential; Female; Humans; Magneti | 2018 |
Contact sensitization to metronidazole from possible occupational exposure.
Topics: Administration, Topical; Adult; Aged; Carcinoma, Basal Cell; Dermatitis, Allergic Contact; Dermatiti | 2009 |
Red nose: primary cutaneous marginal zone B-cell lymphoma.
Topics: Administration, Topical; Aged, 80 and over; Anti-Bacterial Agents; Anti-Infective Agents; Antineopla | 2010 |
Use of intravenous immunoglobulin for the treatment of severe Clostridium difficile colitis.
Topics: Aged; Anti-Bacterial Agents; Carcinoma, Merkel Cell; Clostridioides difficile; Cytotoxins; Diarrhea; | 2007 |
Tumor growth delay studies in patients with multiple metastatic nodules: practical difficulties.
Topics: Humans; Lung Neoplasms; Male; Metronidazole; Middle Aged; Neoplasm Metastasis; Neoplasms; Regression | 1980 |
Metronidazole gel in managing malodorous fungating wounds.
Topics: Bacteria, Anaerobic; Bacterial Infections; Clinical Trials as Topic; Gels; Humans; Metronidazole; Ne | 2002 |
Photosensitizers and radiosensitizers in dermatology and oncology.
Topics: Brain Neoplasms; DNA; Humans; Methoxsalen; Metronidazole; Misonidazole; Mycosis Fungoides; Photochem | 1979 |
Modification of the radiocurability of a syngeneic murine squamous carcinoma by its site of growth, by electron-affinic drugs, and by ICRF 159.
Topics: Animals; Carcinoma, Squamous Cell; Dose-Response Relationship, Radiation; Female; Imidazoles; Metron | 1976 |
[Metronidazole in the combined treatment of malignant melanoma of the skin].
Topics: Adult; Aged; Combined Modality Therapy; Female; Humans; Male; Melanoma; Metronidazole; Middle Aged; | 1989 |