metronidazole has been researched along with Complications, Pregnancy in 30 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the human teratogenic potential of vaginal metronidazole treatment during pregnancy." | 7.73 | Teratogenic potential of vaginal metronidazole treatment during pregnancy. ( Czeizel, AE; Kazy, Z; Puhó, E, 2005) |
| "Topical ivermectin was more effective than metronidazole, but has a more concerning pregnancy category." | 5.12 | Treatment of rosacea during pregnancy. ( Cline, A; Gomolin, T; Pereira, F, 2021) |
| " A histological finding on the 15th day indicated the possibility of amoebic enteritis, and the patient was started on metronidazole therapy." | 3.81 | Fulminant amoebic enteritis that developed in the perinatal period. ( Goto, M; Matsuoka, T; Mizushima, Y, 2015) |
| "To study the human teratogenic potential of vaginal metronidazole treatment during pregnancy." | 3.73 | Teratogenic potential of vaginal metronidazole treatment during pregnancy. ( Czeizel, AE; Kazy, Z; Puhó, E, 2005) |
| "Extra-intestinal manifestations of Crohn's disease are well described." | 2.39 | [Crohn's disease with isolated vulvar localization and pregnancy. A case report]. ( Ben Osmane, A; Bitri, M; Chelly, H; Haouet, S, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (56.67) | 18.7374 |
| 1990's | 5 (16.67) | 18.2507 |
| 2000's | 5 (16.67) | 29.6817 |
| 2010's | 2 (6.67) | 24.3611 |
| 2020's | 1 (3.33) | 2.80 |
| Authors | Studies |
|---|---|
| Gomolin, T | 1 |
| Cline, A | 1 |
| Pereira, F | 1 |
| Waldman, L | 1 |
| Reddy, SB | 1 |
| Kassim, A | 1 |
| Dettloff, J | 1 |
| Reddy, VB | 1 |
| Goto, M | 1 |
| Mizushima, Y | 1 |
| Matsuoka, T | 1 |
| Mastrobattista, JM | 1 |
| Klebanoff, MA | 2 |
| Carey, JC | 2 |
| Hauth, JC | 2 |
| Macpherson, CA | 1 |
| Ernest, J | 1 |
| Cotroneo, M | 1 |
| Leveno, KJ | 2 |
| Wapner, R | 1 |
| Varner, M | 2 |
| Iams, JD | 1 |
| Moawad, A | 2 |
| Sibai, BM | 2 |
| Miodovnik, M | 2 |
| Dombrowski, M | 1 |
| O'Sullivan, MJ | 2 |
| Vandorsten, JP | 1 |
| Langer, O | 2 |
| Pegler, S | 1 |
| McElhatton, P | 1 |
| PERL, G | 1 |
| RAGAZZONI, H | 1 |
| KOTCHER, E | 1 |
| FRICK, CA | 1 |
| GIESEL, LO | 1 |
| MACGILLAVRAY, I | 1 |
| BOURG, R | 1 |
| Kazy, Z | 1 |
| Puhó, E | 1 |
| Czeizel, AE | 1 |
| Ferahbas, A | 1 |
| Utas, S | 1 |
| Mistik, S | 1 |
| Uksal, U | 1 |
| Peker, D | 1 |
| Berenguer, J | 1 |
| Guilhou, JJ | 1 |
| Meynadier, J | 1 |
| Clements, CJ | 1 |
| Bitri, M | 1 |
| Chelly, H | 1 |
| Ben Osmane, A | 1 |
| Haouet, S | 1 |
| Sullivan, C | 1 |
| Smith, LG | 1 |
| Hay, PE | 1 |
| Jones, G | 1 |
| Clark, T | 1 |
| Bewley, S | 1 |
| Hillier, SL | 1 |
| Nugent, RP | 1 |
| Thom, EA | 1 |
| Ernest, JM | 1 |
| Heine, RP | 1 |
| Wapner, RJ | 1 |
| Trout, W | 1 |
| Van Dorsten, JP | 1 |
| Dombrowski, MP | 1 |
| McNellis, D | 1 |
| Roberts, JM | 1 |
| Lennard-Jones, JE | 1 |
| Powell-Tuck, J | 1 |
| Gray, JA | 1 |
| Fort, J | 1 |
| Kawaciuková, J | 1 |
| Meyers, S | 1 |
| Sachar, DB | 1 |
| Korelitz, BI | 1 |
| Lewis, JH | 1 |
| Weingold, AB | 1 |
| Gardó, S | 1 |
| Gacs, M | 1 |
| Crichton, D | 1 |
| Knobel, J | 1 |
| Berget, A | 1 |
| Weber, T | 1 |
| Horský, J | 1 |
| Wingate, MB | 1 |
| Cornes, JS | 1 |
9 reviews available for metronidazole and Complications, Pregnancy
| Article | Year |
|---|---|
Treatment of rosacea during pregnancy.
Topics: Adult; Algorithms; Animals; Anti-Bacterial Agents; Azithromycin; Brimonidine Tartrate; Dermatologic | 2021 |
ADVANCES IN OBSTETRICS AND GYNAECOLOGY.
Topics: Anemia; Antineoplastic Agents; Choriocarcinoma; Contraceptive Agents; Contraceptives, Oral; Female; | 1964 |
[Crohn's disease with isolated vulvar localization and pregnancy. A case report].
Topics: Adult; Crohn Disease; Drug Therapy, Combination; Female; Humans; Metronidazole; Pregnancy; Pregnancy | 1994 |
Management of vulvovaginitis in pregnancy.
Topics: Acyclovir; Anti-Bacterial Agents; Cesarean Section; Female; Gynecology; Humans; Incidence; Laser The | 1993 |
Drug treatment of inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Bacterial Agents; Antidiarrheals; Azathio | 1979 |
Antibacterial prophylaxis--a clinician's view.
Topics: Adult; Anti-Bacterial Agents; Bacterial Infections; Bronchitis; Child; Child, Preschool; Female; Hum | 1979 |
Medical management of Crohn's disease.
Topics: Aminosalicylic Acids; Crohn Disease; Female; Humans; Immunosuppression Therapy; Metronidazole; Pregn | 1990 |
The use of gastrointestinal drugs during pregnancy and lactation.
Topics: Adrenal Cortex Hormones; Animals; Antidiarrheals; Antiemetics; Cathartics; Diuretics; Female; Gastro | 1985 |
[Metronidazole and pregnancy].
Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Female; Fetal Death; Humans; Metronidazole; Preg | 1972 |
2 trials available for metronidazole and Complications, Pregnancy
| Article | Year |
|---|---|
Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection.
Topics: Adult; Animals; Antitrichomonal Agents; Female; Follow-Up Studies; Humans; Infant, Newborn; Infant, | 2001 |
Drug treatment of inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Bacterial Agents; Antidiarrheals; Azathio | 1979 |
20 other studies available for metronidazole and Complications, Pregnancy
| Article | Year |
|---|---|
Neutrophilic Fixed Drug Eruption.
Topics: Adult; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Drug Erupt | 2015 |
Fulminant amoebic enteritis that developed in the perinatal period.
Topics: Adult; Antiprotozoal Agents; Colon; Developed Countries; Dysentery, Amebic; Enteritis; Female; Human | 2015 |
The effect of body mass index on therapeutic response to bacterial vaginosis in pregnancy.
Topics: Adult; Antiprotozoal Agents; Body Mass Index; Female; Humans; Metronidazole; Obesity, Morbid; Overwe | 2008 |
Metronidazole is used for antibiotic associated diarrhoea in pregnancy in UK.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Diarrhea; Female; Humans; Metronidazole; Pregnancy; Pr | 2002 |
FURTHER STUDIES IN TREATMENT OF FEMALE AND MALE TRICHOMONIASIS WITH METRONIDAZOLE.
Topics: Antiprotozoal Agents; Candidiasis, Vulvovaginal; Carrier State; Communicable Diseases; Epidemiology; | 1963 |
THE EFFECT OF METRONIDAZOLE ON VAGINAL MICROBIOLOGY AND MATERNAL AND NEONATAL HEMATOLOGY.
Topics: Adolescent; Blood Cell Count; Candida; Corynebacterium; Female; Hematology; Humans; Hydrogen-Ion Con | 1964 |
[DOES VAGINAL CANDIDIASIS HAVE AN HORMONAL ETIOLOGY?].
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Candidiasis; Candidiasis, Vulvovaginal; Female; | 1964 |
Teratogenic potential of vaginal metronidazole treatment during pregnancy.
Topics: Abnormalities, Drug-Induced; Administration, Intravaginal; Adult; Anti-Infective Agents, Local; Case | 2005 |
Rosacea fulminans in pregnancy: case report and review of the literature.
Topics: Administration, Oral; Administration, Topical; Adult; Anti-Infective Agents; Anti-Inflammatory Agent | 2006 |
[Crohn's disease. Has there been progress in its treatment?].
Topics: Crohn Disease; Drug Combinations; Female; Glucocorticoids; Glucosamine; Humans; Intestinal Obstructi | 1984 |
Rosacea, metronidazole and pregnancy.
Topics: Carcinogens; Female; Humans; Metronidazole; Pregnancy; Pregnancy Complications; Rosacea; Teratogens; | 1980 |
Metronidazole and breast feeding.
Topics: Breast Feeding; Cesarean Section; Diarrhea, Infantile; Female; Humans; Infant; Infant, Newborn; Lact | 1980 |
Therapy of bacterial vaginosis.
Topics: Antitrichomonal Agents; Bacteroides; Bacteroides Infections; Clindamycin; Drug Therapy, Combination; | 1998 |
The weak cervix: failing to keep the baby in or infection out?
Topics: Adult; Anti-Bacterial Agents; Female; Hospitalization; Humans; Metronidazole; Pregnancy; Pregnancy C | 1998 |
[The treatment of the vaginal discharge as a prevention of maternal and new-born diseases (author's transl)].
Topics: Female; Humans; Leukorrhea; Metronidazole; Neomycin; Pregnancy; Pregnancy Complications; Sulfisoxazo | 1976 |
Pregnancy, fertility, and inflammatory bowel disease.
Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Azathioprine; Colitis, Ulcerative; Crohn Disease; Fe | 1985 |
[Therapeutic and prophylactic use of metronidazole (Klion) in obstetric and gynecologic practice].
Topics: Cesarean Section; Female; Genital Diseases, Female; Humans; Hysterectomy; Metronidazole; Obstetric L | 1985 |
The principles of prevention of avoidable maternal death. A study of 538 consecutive maternal deaths in the obstetric unit, King Edward 8th Hospital, Durban, 1953-1971.
Topics: Anesthesia, Inhalation; Anesthesia, Obstetrical; Cesarean Section; Dysentery, Amebic; Emergencies; F | 1973 |
[New drugs for the improvement of gynaecological and obstetric treatment (author's transl)].
Topics: Female; Genital Diseases, Female; Humans; Isoproterenol; Metronidazole; Oxytocin; Pregnancy; Pregnan | 1973 |
Carcinoma in situ in a young primigravida.
Topics: Adult; Biopsy; Carcinoma, Squamous Cell; Female; Humans; Metronidazole; Pregnancy; Pregnancy Complic | 1965 |