metronidazole has been researched along with Acute Hepatic Failure in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Through the Cockayne Syndrome Natural History Study, we have identified 8 cases of acute hepatic failure after metronidazole administration (8% of our cohort), 3 of which were fatal." | 7.81 | Metronidazole Toxicity in Cockayne Syndrome: A Case Series. ( Munkley, J; O'Kelly, S; Stark, Z; Strong, A; Wilson, BT, 2015) |
| " Through the Cockayne Syndrome Natural History Study, we have identified 8 cases of acute hepatic failure after metronidazole administration (8% of our cohort), 3 of which were fatal." | 3.81 | Metronidazole Toxicity in Cockayne Syndrome: A Case Series. ( Munkley, J; O'Kelly, S; Stark, Z; Strong, A; Wilson, BT, 2015) |
| "In patients with acute liver failure (ALF) who suffer from massive hepatocyte loss, liver progenitor cells (LPCs) take over key hepatocyte functions, which ultimately determines survival." | 1.72 | Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure. ( Bantel, H; Ding, H; Dooley, S; Ebert, MPA; Fan, C; Feng, R; Jung, K; Kroll, J; Liebe, R; Lin, T; Liu, H; Macías-Rodríguez, RU; Marx, A; Mertens, PR; Meyer, C; Munker, S; N De Toni, E; Ruiz-Margáin, A; Schiergens, T; Schierwagen, R; Shao, C; Shin, D; Ten Dijke, P; Teufel, A; Trebicka, J; Wandrer, F; Wang, H; Wang, S; Weng, HL; Wimmer, R; Yuan, X; Zhang, L, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, T | 1 |
| Wang, S | 2 |
| Munker, S | 1 |
| Jung, K | 1 |
| Macías-Rodríguez, RU | 1 |
| Ruiz-Margáin, A | 1 |
| Schierwagen, R | 1 |
| Liu, H | 1 |
| Shao, C | 1 |
| Fan, C | 1 |
| Feng, R | 1 |
| Yuan, X | 1 |
| Wandrer, F | 1 |
| Meyer, C | 1 |
| Wimmer, R | 1 |
| Liebe, R | 1 |
| Kroll, J | 1 |
| Zhang, L | 1 |
| Schiergens, T | 1 |
| Ten Dijke, P | 1 |
| Teufel, A | 1 |
| Marx, A | 1 |
| Mertens, PR | 1 |
| Wang, H | 1 |
| Ebert, MPA | 1 |
| Bantel, H | 1 |
| N De Toni, E | 1 |
| Trebicka, J | 1 |
| Dooley, S | 1 |
| Shin, D | 1 |
| Ding, H | 1 |
| Weng, HL | 1 |
| Wilson, BT | 1 |
| Strong, A | 1 |
| O'Kelly, S | 1 |
| Munkley, J | 1 |
| Stark, Z | 1 |
| Agrawal, P | 1 |
| Gandhi, V | 1 |
| Nagral, A | 1 |
| Nagral, S | 1 |
| Severi, C | 1 |
| Zippi, M | 1 |
| Baccini, F | 1 |
| Gentile, G | 1 |
| Bezzi, M | 1 |
| Fiocca, F | 1 |
| Caprilli, R | 1 |
4 other studies available for metronidazole and Acute Hepatic Failure
| Article | Year |
|---|---|
Follistatin-controlled activin-HNF4α-coagulation factor axis in liver progenitor cells determines outcome of acute liver failure.
Topics: Activins; Acute-On-Chronic Liver Failure; Adult; Aged; Animals; Blood Coagulation; Cell Line; Factor | 2022 |
Metronidazole Toxicity in Cockayne Syndrome: A Case Series.
Topics: Adolescent; Anti-Infective Agents; Cockayne Syndrome; Fatal Outcome; Female; Gastrointestinal Diseas | 2015 |
An unusual cause of acute liver failure.
Topics: Aged, 80 and over; Contrast Media; Disease Progression; Drainage; Entamoeba histolytica; Fatal Outco | 2010 |
Amebic liver abscess, Mirizzi syndrome, and acute hepatic failure.
Topics: Anti-Infective Agents; Barium Radioisotopes; Cefoperazone; Cholecystectomy; Diabetes Mellitus, Type | 2004 |