Page last updated: 2024-09-28

Tuberculosis, Hepatic

Infection of the LIVER with species of MYCOBACTERIUM, most often MYCOBACTERIUM TUBERCULOSIS. It is characterized by localized small tuberculous miliary lesions or tumor-like mass (TUBERCULOMA), and abnormalities in liver function tests.

Synonyms(1)

Synonym
Tuberculosis, Hepatic

Research Excerpts

Overview

ExcerptReference
"Hepatic tuberculosis is an unusual form of extrapulmonary tuberculosis and constitutes less than 1% of all cases of tuberculosis."( Jain, TK; Karunanithi, S; Kumar, R; Sharma, P; Vijay, MK, 2014)

Research

Studies (83)

TimeframeStudies, This Condition (%)All Conditions %
pre-199042 (50.60)23.3326
1990's18 (21.69)12.5806
2000's10 (12.05)18.1394
2010's11 (13.25)28.8240
2020's2 (2.41)9.53
DrugIndicatedRelationship StrengthStudiesTrials
nitrates0low10
nitrites0low10
pyrazinamide0low110
ciprofloxacin0low20
isoniazid0low260
leflunomide0low10
mesalamine0low10
metronidazole0low10
aminosalicylic acid0low20
sulfobromophthalein0low20
prednisolone0low30
penicillamine0low10
prednisone0low20
estrone0low10
kanamycin a0low10
cycloserine0low20
cytarabine0low10
isoxazoles0low10
ethambutol0low130
thorium dioxide0low20
sulfur hexafluoride0low10
streptomycin0low150
technetium0low20
barium sulfate0low20
daunorubicin0low10
amikacin0low10
cephalosporin c0low10
fluorodeoxyglucose f180low60
clarithromycin0low10
paromomycin0low10
cortisone0low10
mercaptopurine0low10
thiourea0low10
ethionamide0low20
tin0low10
antimony0low10
sulfur0low10
gadolinium dtpa0low10
sodium glutamate0low10
ro13-99040low20
oxytetracycline, anhydrous0low10
technetium tc 99m sulfur colloid0low10
gadoxetic acid disodium0low10
muramidase0low10
viomycin0low10
rifampin0low160
eye0low10

Protein Targets (481)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
estrogen nuclear receptor alpha200020
peripheral myelin protein 225005
histone acetyltransferase KAT2A isoform 18008
lamin isoform A-delta10100010
ATP-binding cassette sub-family C member 3011011
Multidrug resistance-associated protein 4011011
Bile salt export pump020020
Canalicular multispecific organic anion transporter 1012012
Aminoglycoside 3'-phosphotransferase 0001
ATP-dependent phosphofructokinase6006
Chain A, 2-oxoglutarate Oxygenase7007
Microtubule-associated protein tau8008
thioredoxin glutathione reductase5005
Smad32002
euchromatic histone-lysine N-methyltransferase 2140014
microphthalmia-associated transcription factor isoform 90303
Carbonic anhydrase 10404
Carbonic anhydrase 20404
Tyrosine-protein phosphatase non-receptor type 10011
Chain A, Integrase0101
Chain A, Integrase0101
Chain A, T4 LYSOZYME0011
Chain A, GCN4P10011
Chain B, GCN4P10011
Chain C, GCN4P10011
Chain A, T4 LYSOZYME0011
Chain A, T4 LYSOZYME0011
Chain A, Replicase polyprotein 1ab0101
Chain A, 3C-like proteinase0101
pregnane X receptor4004
thyroid stimulating hormone receptor6006
progesterone receptor8008
retinoid X nuclear receptor alpha8008
peroxisome proliferator-activated receptor delta8008
cellular tumor antigen p53 isoform a4004
Endolysin0011
Cellular tumor antigen p53100010
Integrin beta-34004
Integrin alpha-IIb4004
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE9009
Chain A, HADH2 protein8008
Chain B, HADH2 protein8008
Chain A, Cruzipain2002
TDP1 protein110011
aldehyde dehydrogenase 1 family, member A1120012
EWS/FLI fusion protein7007
cytochrome P450 2C9 precursor5005
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 15005
Gamma-aminobutyric acid receptor subunit pi8109
Cytochrome P450 1A20303
DNA gyrase subunit B0101
DNA gyrase subunit A0101
Cytochrome P450 3A40404
DNA gyrase subunit B0102
DNA gyrase subunit A0204
DNA gyrase subunit B0204
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0102
Cytochrome P450 2D60101
DNA topoisomerase 2-alpha0105
Cytochrome P450 2C9 0303
Gamma-aminobutyric acid receptor subunit beta-18109
Gamma-aminobutyric acid receptor subunit delta8109
Gamma-aminobutyric acid receptor subunit gamma-28109
Gamma-aminobutyric acid receptor subunit alpha-58109
Gamma-aminobutyric acid receptor subunit alpha-38109
DNA gyrase subunit A0102
Gamma-aminobutyric acid receptor subunit gamma-18109
Gamma-aminobutyric acid receptor subunit alpha-28109
Gamma-aminobutyric acid receptor subunit alpha-48109
Gamma-aminobutyric acid receptor subunit gamma-38109
Gamma-aminobutyric acid receptor subunit alpha-68109
Cytochrome P450 2C190202
Multidrug resistance protein MdtK0011
Histamine H2 receptor7007
Gamma-aminobutyric acid receptor subunit alpha-18109
Gamma-aminobutyric acid receptor subunit beta-38109
Gamma-aminobutyric acid receptor subunit beta-28109
DNA gyrase subunit B0303
DNA gyrase subunit A0303
Enoyl-[acyl-carrier-protein] reductase [NADH]0207
Potassium voltage-gated channel subfamily H member 20304
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Integrase 0101
GABA theta subunit8109
Gamma-aminobutyric acid receptor subunit epsilon8109
GLI family zinc finger 3130013
cytochrome P450 family 3 subfamily A polypeptide 4110011
estrogen-related nuclear receptor alpha110011
thyroid hormone receptor beta isoform 28008
importin subunit beta-1 isoform 13003
mitogen-activated protein kinase 15005
snurportin-13003
GTP-binding nuclear protein Ran isoform 12002
urokinase-type plasminogen activator precursor4004
plasminogen precursor4004
urokinase plasminogen activator surface receptor precursor4004
geminin9009
streptokinase A precursor0011
ATP-dependent translocase ABCB10203
Solute carrier organic anion transporter family member 1B30305
Solute carrier organic anion transporter family member 1B10305
endonuclease IV3003
dopamine D1 receptor2002
thioredoxin reductase5005
RAR-related orphan receptor gamma120012
GLS protein6006
AR protein140014
regulator of G-protein signaling 44004
glucocorticoid receptor [Homo sapiens]140014
retinoic acid nuclear receptor alpha variant 1100010
pregnane X nuclear receptor120012
peroxisome proliferator activated receptor gamma5005
vitamin D (1,25- dihydroxyvitamin D3) receptor100010
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a5005
v-jun sarcoma virus 17 oncogene homolog (avian)7007
peripheral myelin protein 22 isoform 13003
atrial natriuretic peptide receptor 1 precursor1001
chromobox protein homolog 17007
heat shock protein beta-14004
flap endonuclease 12002
nuclear factor erythroid 2-related factor 2 isoform 1110011
survival motor neuron protein isoform d5005
cytochrome P450 3A4 isoform 18008
M-phase phosphoprotein 83003
muscarinic acetylcholine receptor M13003
Glucocorticoid receptor06213
Sex hormone-binding globulin0022
Glycine receptor subunit alpha-10606
Corticosteroid-binding globulin0303
Glycine receptor subunit beta0606
Glycine receptor subunit alpha-20606
Glycine receptor subunit alpha-30606
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 434004
Multidrug and toxin extrusion protein 10101
Chain A, N-methyl-D-aspartate Receptor Subunit 10101
Chain A, N-methyl-D-aspartate Receptor Subunit 10101
Chain A, N-methyl-D-aspartate Receptor Subunit 10101
acetylcholinesterase3003
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)4004
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
Bloom syndrome protein isoform 15005
Bile salt export pump0707
Glutamate receptor ionotropic, NMDA 1 0112
Glutamate receptor ionotropic, NMDA 2A 0112
Glutamate receptor ionotropic, NMDA 2B0112
Glutamate receptor ionotropic, NMDA 2C0112
D-alanine--D-alanine ligase0101
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase 0101
Glutamate receptor ionotropic, NMDA 2D0112
Proton-coupled amino acid transporter 10101
Glutamate receptor ionotropic, NMDA 3B0112
Glutamate receptor ionotropic, NMDA 3A0112
glp-1 receptor, partial2002
phosphopantetheinyl transferase9009
USP1 protein, partial9009
nuclear receptor subfamily 1, group I, member 38008
G5005
67.9K protein2002
LMP1 [Human herpesvirus 4]0002
Histone H2A.x6006
thyroid hormone receptor beta isoform a7007
nuclear factor erythroid 2-related factor 2 isoform 25005
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]0101
serine/threonine-protein kinase mTOR isoform 11001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 12002
DNA polymerase iota isoform a (long)5005
transactivating tegument protein VP16 [Human herpesvirus 1]0101
nuclear receptor coactivator 3 isoform a0101
Thymidine kinase 2, mitochondrial0101
Voltage-dependent calcium channel gamma-2 subunit5005
Interferon beta7007
HLA class I histocompatibility antigen, B alpha chain 5005
Thymidine kinase, cytosolic0101
Thymidine kinase0101
Thymidylate synthase0001
Thymidine kinase0101
Glutamate receptor 25005
Deoxycytidine kinase0001
Probable deoxycytidylate deaminase0001
Cytidine deaminase0102
D(1A) dopamine receptor1001
E3 ubiquitin-protein ligase Mdm20101
Enoyl-[acyl-carrier-protein] reductase [NADH] 0101
Inositol hexakisphosphate kinase 15005
Ataxin-25005
Thymidine kinase0101
Deoxynucleoside kinase0101
cytochrome P450 2C9, partial5005
activating transcription factor 64004
Rap guanine nucleotide exchange factor 33003
Glutathione S-transferase P0101
Alpha-tocopherol transfer protein0011
Chain A, TYROSYL-DNA PHOSPHODIESTERASE6006
Chain A, Breast cancer type 1 susceptibility protein2002
Chain A, Putative fructose-1,6-bisphosphate aldolase6006
Chain A, ATP-DEPENDENT DNA HELICASE Q13003
Chain A, Ferritin light chain1001
Luciferase7007
hypoxia-inducible factor 1 alpha subunit3003
PPM1D protein2002
caspase 7, apoptosis-related cysteine protease2002
estrogen receptor 2 (ER beta)4004
farnesoid X nuclear receptor4004
cytochrome P450 2D64004
caspase-32002
aryl hydrocarbon receptor8008
thyroid stimulating hormone receptor4004
Caspase-71001
runt-related transcription factor 1 isoform AML1b1001
vitamin D3 receptor isoform VDRA9009
caspase-31001
core-binding factor subunit beta isoform 21001
huntingtin isoform 22002
histone-lysine N-methyltransferase 2A isoform 2 precursor2002
nuclear receptor ROR-gamma isoform 14004
DNA polymerase kappa isoform 14004
lethal factor (plasmid)1001
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Transthyretin0101
NADH-ubiquinone oxidoreductase chain 40001
72 kDa type IV collagenase0101
Carbonyl reductase [NADPH] 10001
Glutamate receptor 11001
Glutamate receptor 31001
Glutamate receptor 41001
Platelet-activating factor receptor2002
Multidrug resistance-associated protein 1 0203
Spike glycoprotein3003
Inositol monophosphatase 12002
Histone deacetylase 10101
Reverse transcriptase/RNaseH 0101
ATPase family AAA domain-containing protein 54004
Histone deacetylase 80101
Histone deacetylase 60101
Broad substrate specificity ATP-binding cassette transporter ABCG20203
ATAD5 protein, partial3003
NFKB1 protein, partial1001
GALC protein1001
nonstructural protein 13003
arylsulfatase A3003
hexokinase-4 isoform 11001
parathyroid hormone/parathyroid hormone-related peptide receptor precursor3003
glucokinase regulatory protein1001
Estrogen receptor0416
Steryl-sulfatase0101
Aromatase0101
Polyunsaturated fatty acid lipoxygenase ALOX150202
17-beta-hydroxysteroid dehydrogenase type 10203
Androgen receptor0303
Sodium-dependent serotonin transporter0202
Mu-type opioid receptor0011
Alpha-synuclein0202
5-hydroxytryptamine receptor 2B0202
Solute carrier organic anion transporter family member 1A10202
Mu-type opioid receptor0011
Cytochrome P450 1B10101
Estrogen receptor beta0315
Ghrelin O-acyltransferase0101
Pantothenate synthetase0202
DNA polymerase beta2002
Polyphenol oxidase 20304
Nuclear receptor ROR-gamma3003
bromodomain adjacent to zinc finger domain 2B3003
3-oxoacyl-[acyl-carrier-protein] synthase 3 0101
cytochrome P450 2D6 isoform 11001
potassium voltage-gated channel subfamily H member 2 isoform d1001
N-glycosylase/DNA lyase0101
Myeloperoxidase0101
Formamidopyrimidine-DNA glycosylase0101
Cytochrome P450 2C80101
Cytochrome P450 2A60101
Macrophage migration inhibitory factor0101
Endonuclease III-like protein 10101
Isocitrate lyase0101
Putative FAD-containing monooxygenase MymA0101
Dihydrofolate reductase0101
Endonuclease 8-like 10101
3-oxoacyl-[acyl-carrier-protein] synthase 30101
Gap junction alpha-1 protein0101
Gap junction beta-2 protein0101
Acyl-protein thioesterase 10101
matrix metalloproteinase 1, partial0011
Fumarate hydratase2002
Thrombopoietin1001
polyprotein2002
Parkin2002
P531001
pyruvate kinase1001
IDH12002
nuclear receptor subfamily 1, group I, member 22002
NPC intracellular cholesterol transporter 1 precursor1001
cytochrome P450 2C19 precursor2002
histone deacetylase 9 isoform 31001
ras-related protein Rab-9A1001
neuropeptide S receptor isoform A2002
Dihydroorotate dehydrogenase (quinone), mitochondrial0101
Aldo-keto reductase family 1 member B10202
Amine oxidase [flavin-containing] A0101
Endothelin receptor type B1001
Sodium-dependent noradrenaline transporter 0202
Endothelin-1 receptor1001
Sodium-dependent dopamine transporter 0202
Dihydroorotate dehydrogenase (quinone), mitochondrial0101
Dihydroorotate dehydrogenase (quinone), mitochondrial0101
Protein-arginine deiminase type-40404
Chain A, Beta-lactamase2002
Chain A, JmjC domain-containing histone demethylation protein 3A2002
apical membrane antigen 1, AMA12002
hemoglobin subunit beta1001
transcriptional regulator ERG isoform 32002
UDP-glucose 6-dehydrogenase0101
Solute carrier family 22 member 80001
Hypoxanthine-guanine phosphoribosyltransferase0001
UDP-glucose 6-dehydrogenase0101
Prostaglandin G/H synthase 10101
Purine nucleoside phosphorylase0011
UDP-glucuronosyltransferase 1A1 0101
15-lipoxygenase, partial2002
caspase-1 isoform alpha precursor1001
Solute carrier organic anion transporter family member 2B1 0203
Tumor necrosis factor0101
Neuraminidase0101
Prostaglandin G/H synthase 10202
60 kDa chaperonin0101
60 kDa heat shock protein, mitochondrial0202
Cystathionine gamma-lyase0202
Prostaglandin G/H synthase 20303
Caspase-71001
10 kDa heat shock protein, mitochondrial0202
Thiosulfate sulfurtransferase0202
60 kDa chaperonin 0202
10 kDa chaperonin 0202
Cystine/glutamate transporter0101
Hydroxyacid oxidase 10101
large T antigen0101
Thioredoxin reductase 0101
muscleblind-like protein 1 isoform 13003
Flavodoxin0001
Voltage-dependent L-type calcium channel subunit alpha-1F0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0101
Voltage-dependent L-type calcium channel subunit alpha-1S0101
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Lanosterol 14-alpha demethylase0202
Carbonic anhydrase 40202
Carbonic anhydrase0202
Sodium/iodide cotransporter0101
Carbonic anhydrase 150202
WRN1001
Valosin-containing protein0101
lysosomal alpha-glucosidase preproprotein1001
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
serine/threonine-protein kinase PLK11001
DNA polymerase eta isoform 11001
eukaryotic translation initiation factor 4E isoform 10101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Neuronal acetylcholine receptor subunit alpha-41001
Neuronal acetylcholine receptor subunit beta-21001
Serum paraoxonase/arylesterase 10101
phosphoglycerate kinase1001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Tyrosyl-DNA phosphodiesterase 10101
Succinyl-diaminopimelate desuccinylase0101
Estrogen receptor 10101
D(1A) dopamine receptor1001
fMet-Leu-Phe receptor0101
Prostaglandin G/H synthase 2 0101
Prostaglandin G/H synthase 1 0101
Nicotinate phosphoribosyltransferase0101
Cyclooxygenase-2 0101
Solute carrier family 22 member 80101
luciferase0001
Fatty acid-binding protein, liver0101
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Nociceptin receptor0011
Cytochrome P450 2J20101
NAD-dependent protein deacetylase sirtuin-60101
interleukin 81001
DNA-directed RNA polymerase subunit beta0101
Solute carrier organic anion transporter family member 1A40101
Nuclear receptor subfamily 1 group I member 20011
Albumin0011
NH(3)-dependent NAD(+) synthetase0101
Cytochrome P450 2B60011
Arylacetamide deacetylase0102
Caspase-10101
Solute carrier organic anion transporter family member 1A20101
Glutathione S-transferase omega-10101
DNA-directed RNA polymerase subunit beta0101
Hematopoietic prostaglandin D synthase0101
isocitrate dehydrogenase 1, partial1001
serine-protein kinase ATM isoform a1001
Alcohol dehydrogenase E chain0101
Alcohol dehydrogenase S chain0101
Urease0203
5-hydroxytryptamine receptor 2A0101
Urease subunit alpha0101
D(3) dopamine receptor0101
5-hydroxytryptamine receptor 1A0101
Urease subunit alpha0101
Urease subunit beta0101
Urease subunit beta 0101
Serine-protein kinase ATM0101
Serine/threonine-protein kinase ATR0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain B, Odorant-binding Protein0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain A, ODORANT-BINDING PROTEIN0101
Chain A, ODORANT-BINDING PROTEIN0101
Acetylcholinesterase0101
Transient receptor potential cation channel subfamily A member 10011
Cholinesterase0101
Secreted chorismate mutase0101
Heat sensitive channel TRPV30011
Transient receptor potential cation channel subfamily A member 10112
Transient receptor potential cation channel subfamily M member 80112
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]