metronidazole has been researched along with Periodontitis in 333 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Periodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
| Excerpt | Relevance | Reference |
|---|---|---|
| " A single-blind clinical trial was carried out in 13 patients with adult periodontitis to compare the effects of subgingival application of metronidazole dental gel with those of subgingival scaling." | 10.18 | Comparison of the clinical effects of subgingival application of metronidazole 25% gel and scaling in the treatment of adult periodontitis. ( Awartani, FA; Zulqarnain, BJ, 1998) |
| "Despite the body of evidence supporting the clinical benefits of metronidazole (MTZ) and amoxicillin (AMX) in the treatment of young patients with periodontitis, the microbiological outcomes of this antibiotic protocol have been less explored." | 9.69 | Microbiological effects of amoxicillin plus metronidazole in the treatment of young patients with Stages III and IV periodontitis: A secondary analysis from a 1-year double-blinded placebo-controlled randomized clinical trial. ( Barão, VAR; de Figueiredo, LC; Duarte, PM; Faveri, M; Feres, M; Mestnik, MJ; Retamal-Valdes, B; Souza, JGS, 2023) |
| "In generalized periodontitis stage III/grade C, a clinically relevant lower percentage of disease progression after adjunctive systemic amoxicillin/metronidazole was observed compared to placebo (PLAC: 9." | 9.69 | Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis stage and grade: An exploratory sub-analysis of the ABPARO trial. ( Ehmke, B; Eickholz, P; Göde, M; Harks, I; Kaner, D; Kim, TS; Koch, R; Kocher, T; Lorenz, K; Meyle, J; Nickles, K; Schlagenhauf, U, 2023) |
| "Systemically healthy patients, with stages III-IV, grades B-C periodontitis, were randomly assigned to receive metronidazole or placebo adjunctive to periodontal surgery, after subgingival instrumentation." | 9.51 | Adjunctive efficacy of systemic metronidazole in the surgical treatment of periodontitis: a double-blind parallel randomized clinical trial. ( Collins, JR; Figuero, E; González, R; Herrera, D; Marín, MJ; Ogando, G; Sanz, M, 2022) |
| "The aim of this study was to perform a 5-year follow-up analysis of a previously-published randomized trial (RCT) evaluating the 2-years effects of metronidazole (MTZ) plus amoxicillin (AMX) as adjuncts to scaling and root planing (SRP) in the treatment of periodontitis in type 2 diabetic patients." | 9.41 | Metronidazole and amoxicillin for patients with periodontitis and diabetes mellitus: 5-year secondary analysis of a randomized controlled trial. ( Cruz, DFD; da Silva, HDP; Duarte, PM; Feres, M; Figueiredo, LC; Miranda, TS; Retamal-Valdes, B, 2021) |
| "To determine the efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen during nonsurgical treatment of periodontitis in patients with type 2 diabetes mellitus." | 9.34 | Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial. ( Espinel-Bermudez, MC; Gómez-Sandoval, JR; Hernández-González, SO; Mariaud-Schmidt, R; Martínez-Rodríguez, V; Mercado-Sesma, AR; Morgado-Castillo, KC; Robles-Cervantes, JA, 2020) |
| " We hypothesize, if variables fall below or exceed these threshold levels, systemic amoxicillin/metronidazole may contribute to reducing progression of periodontitis." | 9.30 | Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age: An exploratory sub-analysis of the ABPARO trial. ( Ehmke, B; Eickholz, P; Harks, I; Harmsen, D; Hoffmann, T; Kaner, D; Kim, TS; Koch, R; Kocher, T; Meyle, J; Schlagenhauf, U, 2019) |
| "To evaluate the clinical outcomes 12 months after systemic administration of amoxicillin (AMX) and metronidazole (MET) adjunctive to subgingival debridement (SD) in patients with severe chronic periodontitis (sChP)." | 9.24 | One year results of a randomized controlled clinical study evaluating the effects of non-surgical periodontal therapy of chronic periodontitis in conjunction with three or seven days systemic administration of amoxicillin/metronidazole. ( Arweiler, NB; Cosgarea, R; Heumann, C; Juncar, R; Lascu, L; Salvi, GE; Sculean, A; Tristiu, R, 2017) |
| "Systemic amoxicillin-metronidazole was proven to be effective in managing periodontitis in systemically healthy patients." | 9.22 | Efficacy of Systemic Amoxicillin-Metronidazole in Periodontitis Patients with Diabetes Mellitus: A Systematic Review of Randomized Clinical Trials. ( Mugri, MH, 2022) |
| "The aim of this study was to assess the changes occurring in subgingival biofilm composition and in the periodontal clinical parameters of subjects with periodontitis and type 2 diabetes mellitus (DM) treated by means of scaling and root planing (SRP) only or combined with systemic metronidazole (MTZ) and amoxicillin (AMX)." | 9.22 | Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Maciel, SS; Miranda, TS; Tamashiro, NS, 2016) |
| "This paper aimed to study the effect of metronidazole sustained-release film combined with minocycline hydrochloride on treating periodontitis." | 9.20 | Clinical picture of combination therapy (metronidazole sustained release film with minocycine hydrochloride) in periodontitis. ( Yang, Z, 2015) |
| "The aim is to explore the optimal drug dose and duration of adjunctive Amoxicillin-plus-Metronidazole (AMX/MET) to full-mouth scaling and planing (FMSRP) in periodontitis." | 9.12 | The effect of drug dose and duration of adjuvant Amoxicillin-plus-Metronidazole to full-mouth scaling and root planing in periodontitis: a systematic review and meta-analysis. ( Hu, J; Zhao, H; Zhao, L, 2021) |
| " The purpose of this study was to evaluate the clinical effectiveness of chitosan, both as a carrier in gel form and as an active agent in the treatment of chronic periodontitis (CP)." | 9.12 | Application of chitosan gel in the treatment of chronic periodontitis. ( Akncbay, H; Ay, ZY; Senel, S, 2007) |
| "To determine the effect of metronidazole plus amoxicillin (M+A) as the sole therapy, on the subgingival microbiota of chronic periodontitis." | 9.12 | Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. ( Da Silva, I; Haffajee, AD; Japlit, MR; López, NJ; Socransky, SS, 2006) |
| "The aims of the present study were to evaluate the clinical efficacy of, and to monitor microbiologically, repeated oral hygiene instructions alone or in combination with metronidazole 25% gel or subgingival scaling with or without metronidazole gel in treatment of new, residual or recurrent periodontal pockets in previously treated adult periodontitis patients." | 9.12 | Repeated oral hygiene instructions alone, or in combination with metronidazole dental gel with or without subgingival scaling in adult periodontitis patients: a one-year clinical study. ( Corbet, EF; Lee, DH; Zee, KY, 2006) |
| "Subgingival application of chlorhexidine via a controlled-delivery device (CHX chip) improves the clinical outcome of scaling/root planing (SRP) in therapy for chronic periodontitis." | 9.12 | Controlled-delivery chlorhexidine chip versus amoxicillin/metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis: a randomized controlled clinical trial. ( Bernimoulin, JP; Friedmann, A; Hopfenmüller, W; Kaner, D; Kleber, BM, 2007) |
| "The current investigation evaluated the clinical effects of scaling and root planing (SRP) alone or in combination with systemic metronidazole and/or repeated professional removal of supragingival plaque in subjects with chronic periodontitis." | 9.11 | Scaling and root planing, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population. I. clinical results. ( Carvalho, LH; D'Avila, GB; Feres, M; Haffajee, AD; Leão, A; Socransky, SS, 2004) |
| "Previous studies have shown that metronidazole, alone or in combination with spiramycin (250 mg/1 500 000 units, three times/day), is an effective treatment for active periodontitis, although the dose of metronidazole currently used (750 mg/day) could provide concentrations in gingival crevice fluid that are too low for the MICs of the involved pathogens." | 9.11 | Concentrations and in vivo antibacterial activity of spiramycin and metronidazole in patients with periodontitis treated with high-dose metronidazole and the spiramycin/metronidazole combination. ( Barthet, P; Brumpt, I; Duffaut, D; Poulet, PP, 2005) |
| "The current investigation evaluated changes in levels and proportions of 39 bacterial species in subgingival plaque samples after scaling and root planing (SRP) alone or in combination with systemic metronidazole and/or professional cleaning in subjects with chronic periodontitis." | 9.11 | Scaling and root planing, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population II--microbiological results. ( Carvalho, LH; D'Avila, GB; Feres, M; Gonçalves, C; Haffajee, AD; Leão, A; Socransky, SS, 2005) |
| "The objective of this study was to assess the adjunctive clinical effect of the administration of systemic amoxicillin and metronidazole in the non-surgical treatment of generalized aggressive periodontitis (GAP)." | 9.11 | Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. ( Griffiths, GS; Guerrero, A; Laurell, L; Moles, DR; Nibali, L; Suvan, J; Tonetti, MS, 2005) |
| "The aim of the present study was to evaluate the clinical and microbiological effects of subgingival application of 25% metronidazole dental gel as an adjunct to scaling and root planing (SRP) in the treatment of adult periodontitis." | 9.09 | Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis; 12-months results. ( Bilgiç, A; Buduneli, E; Evrenosoglu, E; Tünger, A, 2001) |
| "The aim of this double-blind, parallel study was to evaluate the adjunctive effects of systemically administered amoxicillin and metronidazole in a group of adult periodontitis patients who also received supra- and subgingival debridement." | 9.09 | Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. ( Timmerman, MF; Van der Velden, U; Van der Weijden, GA; Van Winkelhoff, AJ; Winkel, EG, 2001) |
| "In this article the clinical and microbiological effects of systemic metronidazole in the treatment of refractory periodontitis in adult patients is discussed." | 9.09 | [Metronidazole in the treatment of refractory periodontitis]. ( van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 2000) |
| "The present study describes results on selected clinical and microbiological parameters obtained by treatment with local (Elyzol) and systemic (Flagyl) use of metronidazole alone and/or mechanical subgingival debridement in adult periodontitis." | 9.08 | A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients. ( Acar, O; Büget, E; Kadir, T; Kuru, B; Noyan, U; Yilmaz, S, 1997) |
| "The Effect on the subgingival microflora of a single topical administration of a 95% collagen and 5% metronidazole device in combination with debridement was investigated in 30 adult periodontitis patients in comparison with mechanical treatment alone." | 9.08 | Effects of combined topical metronidazole and mechanical treatment on the subgingival flora in deep periodontal pockets in cuspids and bicuspids. ( Bitton, C; Charbit, Y; Fosse, T; Hannoun, L; Hitzig, C, 1997) |
| "The present study describes selected clinical and microbiological results obtained by treatment with local (Elyzol) and systemic (Flagyl) use of metronidazole alone and/or mechanical subgingival debridement in early onset periodontitis (EOP)." | 9.08 | A clinical and microbiological evaluation of systemic and local metronidazole delivery in early onset periodontitis patients. ( Acar, O; Büget, E; Kadir, T; Kuru, B; Noyan, U; Yilmaz, S, 1996) |
| "Fifty-two adult periodontitis patients were treated by the tablets of tinidazole (TNZ), and 23 patients treated by metronidazole (MNZ) served as control group." | 9.08 | [The effect of tinidazole in the treatment of adult periodontitis]. ( Chen, L; Ni, K; Wang, R, 1996) |
| "To compare clinical and microbiological responses following non-surgical treatment of moderate to advanced adult periodontitis using subgingival scaling with and without adjunctive topical or systemic metronidazole." | 9.08 | Adjunctive systemic and locally delivered metronidazole in the treatment of periodontitis: a controlled clinical study. ( Matthews, JP; Palmer, RM; Wilson, RF, 1998) |
| "The present study was performed to assess and compare the clinical healing and the microbiological findings following local application of metronidazole or tetracycline to augment subgingival scaling in previously untreated adult periodontitis sites." | 9.08 | Effects of topical metronidazole and tetracycline in treatment of adult periodontitis. ( Böe, OE; Bruun, G; Lie, T, 1998) |
| "A randomized, double-blind, clinical study was done to assess the microbiological and clinical effects of metronidazole plus amoxicillin (M+A) as the only therapy in 46 patients with moderate to advanced progressive adult periodontitis." | 9.08 | Effects of metronidazole plus amoxicillin in progressive untreated adult periodontitis: results of a single 1-week course after 2 and 4 months. ( Gamonal, JA; López, NJ, 1998) |
| "In this study, we evaluated the microbiological and clinical effects of mechanical debridement in combination with metronidazole and amoxicillin therapy in 48 patients with Actinobacillus actinomycetemcomitans-associated periodontitis, 3 months and at least 24 months after active treatment." | 9.07 | Microbiological and clinical effects of metronidazole and amoxicillin in Actinobacillus actinomycetemcomitans-associated periodontitis. A 2-year evaluation. ( de Graaff, J; Douqué, NH; Pavicić, MJ; Steures, RW; van Winkelhoff, AJ, 1994) |
| "The purpose of this study was to evaluate the clinical effects of a single application of a 5% metronidazole collagen device in periodontal pockets deeper than 5 mm, in association with debridement and without reinforcement of home care and hygiene as practiced by the patient at any time." | 9.07 | Topical metronidazole as an adjunct to subgingival debridement in the treatment of chronic periodontitis. ( Bitton, C; Charbit, Y; Fosse, T; Hannoun, L; Hitzig, C; Teboul, M; Varonne, R, 1994) |
| "The aim of the study was to compare the clinical and microbiological effects of topical application of a metronidazole gel and a single session of subgingival scaling in the treatment of adult periodontitis." | 9.07 | Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. ( Karring, T; Kilian, M; Pedrazzoli, V, 1992) |
| "A newly developed metronidazole 25% dental gel was compared with subgingival scaling in the treatment of adult periodontitis." | 9.07 | Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. ( Ainamo, J; Ellingsen, BH; Hansen, BF; Johansson, LA; Karring, T; Kisch, J; Lie, T; Paunio, K; Stoltze, K, 1992) |
| "The efficacy of metronidazole and doxycycline in preventing recurrent periodontitis was studied in 23 patients." | 9.07 | Serial doxycycline and metronidazole in prevention of recurrent periodontitis in high-risk patients. ( Aitken, S; Birek, P; Kulkarni, GV; Lee, WL; McCulloch, CA, 1992) |
| "The effect of adjunctive systemic metronidazole was studied in patients with moderate and advanced periodontitis recalcitrant to comprehensive non-surgical treatment." | 9.06 | The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults. ( Engström, PE; Frithiof, L; Nedlich, U; Rubin, B; Söder, B; Söder, PO; Wikner, S; Wouters, F, 1990) |
| "Meta-analysis was used to assess the effectiveness of local delivery of metronidazole alone or as an adjunct to mechanical therapy in patients with chronic periodontitis." | 8.82 | Meta-analysis of local metronidazole in the treatment of chronic periodontitis. ( Angelillo, IF; Bianco, A; Nobile, CG; Pavia, M, 2004) |
| "The purpose of this meta-analysis was to provide a quantitative overview of clinical trials assessing the use of systemic metronidazole (S-MET) as an adjunct to scaling and root planning (S&RP) in the treatment of adult periodontitis." | 8.79 | Meta-analysis of the effect of systemic metronidazole as an adjunct to scaling and root planing for adult periodontitis. ( Beck, JD; Elter, JR; Lawrence, HP; Offenbacher, S, 1997) |
| "Mechanical treatment associated with metronidazole and amoxicillin promoted a beneficial change in the microbiome of young individuals with severe periodontitis." | 8.02 | Microbiome changes in young periodontitis patients treated with adjunctive metronidazole and amoxicillin. ( Bittinger, K; Faveri, M; Feres, M; Fermiano, D; Figueiredo, LC; Lee, JJ; Mayer, MPA; Retamal-Valdes, B; Teles, F, 2021) |
| "The aim of this follow-up study was, to compare the effects of mechanical periodontal therapy with or without adjunctive amoxicillin and metronidazole on the subgingival microbiome of smokers with periodontitis using 16S rDNA amplicon next generation sequencing." | 7.96 | Significant Short-Term Shifts in the Microbiomes of Smokers With Periodontitis After Periodontal Therapy With Amoxicillin & Metronidazole as Revealed by 16S rDNA Amplicon Next Generation Sequencing. ( Ehmke, B; Eickholz, P; Hagenfeld, D; Harks, I; Harmsen, D; Kaner, D; Kim, TS; Kocher, T; Lorenz, K; Matern, J; Meyle, J; Prior, K; Schlagenhauf, U, 2020) |
| "This study aimed to develop pH-responsive polylactide-glycolic acid co-polymer and chitosan (PLGA/chitosan) nanosphere as an inflammation-responsive vehicle and evaluate the potential of the nanosphere encapsulating metronidazole, an antibiotic, and N-phenacylthiazolium bromide (PTB), a host modulator, for treating periodontitis." | 7.88 | Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide. ( Chang, PC; Feng, F; Lin, JH; Wang, CH; Yu, MC, 2018) |
| "To evaluate if non-diabetic subjects with periodontitis respond better than subjects with type 2 diabetes to the treatment protocol of scaling and root planing (SRP), metronidazole (MTZ) and amoxicillin (AMX)." | 7.88 | Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Miranda, TS; Retamal-Valdes, B; Soares, GMS; Yassine, LLS, 2018) |
| "Metronidazole (MZ) and levofloxacin (LF) are widely employed for treatment of periodontitis, but high oral dose and resistance development after long-term oral administration limit their use." | 7.83 | Development and Evaluation of Biodegradable Chitosan Films of Metronidazole and Levofloxacin for the Management of Periodontitis. ( Bansal, M; Khan, G; Mishra, B; Nath, G; Patel, RR; Yadav, SK, 2016) |
| "We aimed to achieve detailed biomaterials characterization of a drug delivery system for local periodontitis treatment based on electrospun metronidazole-loaded resorbable polylactide (PLA) fibers." | 7.78 | Release of metronidazole from electrospun poly(L-lactide-co-D/L-lactide) fibers for local periodontitis treatment. ( Berg, A; Jandt, KD; Müller, U; Reise, M; Schnabelrauch, M; Sigusch, BW; Völpel, A; Watts, DC; Wyrwa, R; Zylinski, M, 2012) |
| "The purpose of this study is to formulate in situ implants containing doxycycline hydrochloride and/or secnidazole that could be used in the treatment of periodontitis by direct periodontal intrapocket administration." | 7.74 | Formulation and evaluation of PLA and PLGA in situ implants containing secnidazole and/or doxycycline for treatment of periodontitis. ( Abd El-Hady, SS; El-Nabarawi, MA; Gad, HA, 2008) |
| "This study was designed to evaluate the clinical effects of metronidazole ofloxacin gel (MO gel) as an adjunct to conventional therapy for periodontitis." | 7.71 | [Clinical effects of metronidazole-ofloxacin gel as an adjunct to conventional therapy for periodontitis]. ( Wang, X; Xu, Y; Yang, H; Zhang, J, 2001) |
| "After baseline clinical and microbiological monitoring, 17 adult periodontitis subjects received full mouth SRP and 14 days systemic administration of either metronidazole (250 mg, TID, n=8) or amoxicillin (500 mg, TID, n=9)." | 7.71 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. ( Allard, K; Feres, M; Haffajee, AD; Socransky, SS; Som, S, 2001) |
| "The aim of the present study was to monitor the microbiological and clinical effects of renewed supra- and subgingival debridement in conjunction with systemic metronidazole therapy (500 mg TID for 7 days) in 27 "refractory" periodontitis patients, culture positive for Bacteroides forsythus and negative for Actinobacillus actinomycetemcomitans." | 7.69 | Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus. ( Timmerman, MF; Van der Velden, U; Van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 1997) |
| "We report on the microbiological and clinical effects of mechanical debridement in combination with metronidazole plus amoxicillin therapy in 118 patients with Actinobacillus actinomycetemcomitans-associated periodontitis." | 7.68 | Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis. ( de Graaff, J; Tijhof, CJ; van Winkelhoff, AJ, 1992) |
| "The present study was performed to assess the effect of topical metronidazole therapy on ligature-induced periodontitis in beagle dogs." | 7.68 | The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog. ( Attström, R; Edwardsson, S; Kalfas, S; Klinge, B; Kuvatanasuhati, J, 1992) |
| "Systemic administration of metronidazole during an experimental periodontitis resulted in significantly less active tissue destruction compared to drug-free animals." | 7.68 | Effect of metronidazole on experimental periodontitis: cell population characteristics. ( Espeland, MA; Polson, AM; Zappa, UE, 1992) |
| " This study attempts to measure changes in flora by a number of methods following the placement of 40% metronidazole acrylic strips into periodontal pockets." | 7.67 | Simple bacteriological methods to assess changes in subgingival microflora produced by metronidazole-containing acrylic strips placed into periodontal pockets. ( Addy, M; Alam, L; Rawle, L, 1984) |
| "5%) and the other high (40%) dose metronidazole locally in periodontal pockets once a week for 4 weeks." | 7.67 | Slow release metronidazole and a simplified mechanical oral hygiene regimen in the control of chronic periodontitis. ( Addy, M; Newman, HN; wan Yusof, WZ; Yeung, FI, 1984) |
| "5% metronidazole solutions on the clinical and microbiologic parameters of adult periodontitis as compared with scaling and root planing." | 7.67 | Clinical and microbiologic changes following the irrigation of periodontal pockets with metronidazole or stannous fluoride. ( Bissada, NF; Lazzaro, AJ, 1989) |
| "The present study evaluated the effect of systemic metronidazole on advanced periodontitis in 10 patients with inadequate oral hygiene." | 7.67 | Systemic metronidazole in the treatment of periodontitis. ( Gilmour, WH; Jenkins, WM; MacFarlane, TW; MacKenzie, D; Ramsay, I, 1989) |
| "The aim of this study was to evaluate the effects of a gel containing 4% metronidazole and collagen in periodontal pockets deeper than 4 mm." | 7.67 | [Experimental study of a metronidazole gel inserted in periodontal pockets]. ( Bitton-Sebag, C; Charbit, Y; Hitzig, C; Lapougeas, JC; Teboul, M, 1989) |
| "The potential use of an adjunctive therapy of metronidazole plus amoxycillin for the subgingival elimination of Actinobacillus actinomycetemcomitans in periodontitis patients was investigated." | 7.67 | Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. ( Abbas, F; de Graaff, J; Goené, RJ; Rodenburg, JP; van Winkelhoff, AJ; Winkel, EG, 1989) |
| "Niridazole, metronidazole and tetracycline were compared for their activity against subgingival bacteria from patients with chronic periodontitis." | 7.67 | Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis. ( Addy, M; Wade, WG, 1987) |
| "Sites affected with adult periodontitis were observed for 3 months to compare their clinical and microbiologic responses to a single 2 g dose of metronidazole, scaling and root planing, or no treatment." | 7.67 | Clinical and microbiologic effects of single-dose metronidazole or scaling and root planing in treatment of adult periodontitis. ( Armitage, GC; Buchanan, SA; Hoover, CI; Newbrun, E; Robertson, PB; Taggart, EJ; Walsh, MM, 1986) |
| "To explore the efficacy and safety of ornidazole combined with periodontal tissue regeneration in the treatment of periodontitis." | 6.94 | [Study on the efficacy and safety of metronidazole combined with periodontal tissue regeneration in the treatment of periodontitis]. ( DA, Y; Wang, MJ; Zheng, LC, 2020) |
| "The formulated SLMs gel offers an applicable dosage form that can be injected directly into the periodontal pocket as adjunctive to scaling and root planing." | 6.84 | Doxycycline hydrochloride-metronidazole solid lipid microparticles gels for treatment of periodontitis: development, in-vitro and in-vivo clinical evaluation. ( El Dessouky, HF; Ezzat, OM; Gad, HA; Kamel, AO; Sammour, OA, 2017) |
| "Metronidazole is an agent with reported success in the treatment of anaerobic periodontal infections." | 6.67 | Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters. ( Giordano, J; Grossman, N; Loesche, WJ, 1993) |
| " However, there are reasons to suggest that local delivery of metronidazole should not be used as a substitute for conventional treatment of periodontal disease, since side-effects of long-term use and repeated use are not known." | 6.40 | The use of locally delivered metronidazole in the treatment of periodontitis. Clinical results. ( Magnusson, I, 1998) |
| " Review of the drug's pharmacology and potential side effects indicate that it poses little threat to humans of inducing acute toxicity, mutagenesis, or cancer if used according to recommended dosing regimens." | 6.38 | The role of metronidazole in the treatment of periodontal diseases. ( Greenstein, G, 1993) |
| " A single-blind clinical trial was carried out in 13 patients with adult periodontitis to compare the effects of subgingival application of metronidazole dental gel with those of subgingival scaling." | 6.18 | Comparison of the clinical effects of subgingival application of metronidazole 25% gel and scaling in the treatment of adult periodontitis. ( Awartani, FA; Zulqarnain, BJ, 1998) |
| "Periodontitis is a chronic inflammatory disease that leads to the loss of alveolar bone, among several studies focusing on reconstructing periodontal bone caused by periodontitis, guided bone regeneration (GBR) is a promising approach." | 5.91 | Comprehensive reparative effects of bacteriostatic poly(L-lactide-co-glycolide)/poly(L-lactide-co-ε-caprolactone) electrospinning membrane on alveolar bone defects in progressive periodontitis. ( Han, M; Liu, Y; Mi, F; Wang, B; Zhao, Y; Zhu, W, 2023) |
| "Despite the body of evidence supporting the clinical benefits of metronidazole (MTZ) and amoxicillin (AMX) in the treatment of young patients with periodontitis, the microbiological outcomes of this antibiotic protocol have been less explored." | 5.69 | Microbiological effects of amoxicillin plus metronidazole in the treatment of young patients with Stages III and IV periodontitis: A secondary analysis from a 1-year double-blinded placebo-controlled randomized clinical trial. ( Barão, VAR; de Figueiredo, LC; Duarte, PM; Faveri, M; Feres, M; Mestnik, MJ; Retamal-Valdes, B; Souza, JGS, 2023) |
| "In generalized periodontitis stage III/grade C, a clinically relevant lower percentage of disease progression after adjunctive systemic amoxicillin/metronidazole was observed compared to placebo (PLAC: 9." | 5.69 | Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis stage and grade: An exploratory sub-analysis of the ABPARO trial. ( Ehmke, B; Eickholz, P; Göde, M; Harks, I; Kaner, D; Kim, TS; Koch, R; Kocher, T; Lorenz, K; Meyle, J; Nickles, K; Schlagenhauf, U, 2023) |
| "Systemically healthy patients, with stages III-IV, grades B-C periodontitis, were randomly assigned to receive metronidazole or placebo adjunctive to periodontal surgery, after subgingival instrumentation." | 5.51 | Adjunctive efficacy of systemic metronidazole in the surgical treatment of periodontitis: a double-blind parallel randomized clinical trial. ( Collins, JR; Figuero, E; González, R; Herrera, D; Marín, MJ; Ogando, G; Sanz, M, 2022) |
| "A 6-month pilot randomized controlled trial recruited 14 subjects with severe periodontitis, divided into test group and control group to receive full-mouth SRP with or without amoxicillin (500 mg) and metronidazole (200 mg) (three times a day for 7 days)." | 5.51 | Effect of adjunctive systemic antibiotics on microbial populations compared with scaling and root planing alone for the treatment of periodontitis: A pilot randomized clinical trial. ( He, L; Jin, D; Lu, H; Meng, H; Zhu, Y, 2022) |
| "The aim of this study was to perform a 5-year follow-up analysis of a previously-published randomized trial (RCT) evaluating the 2-years effects of metronidazole (MTZ) plus amoxicillin (AMX) as adjuncts to scaling and root planing (SRP) in the treatment of periodontitis in type 2 diabetic patients." | 5.41 | Metronidazole and amoxicillin for patients with periodontitis and diabetes mellitus: 5-year secondary analysis of a randomized controlled trial. ( Cruz, DFD; da Silva, HDP; Duarte, PM; Feres, M; Figueiredo, LC; Miranda, TS; Retamal-Valdes, B, 2021) |
| "To determine the efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen during nonsurgical treatment of periodontitis in patients with type 2 diabetes mellitus." | 5.34 | Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial. ( Espinel-Bermudez, MC; Gómez-Sandoval, JR; Hernández-González, SO; Mariaud-Schmidt, R; Martínez-Rodríguez, V; Mercado-Sesma, AR; Morgado-Castillo, KC; Robles-Cervantes, JA, 2020) |
| " The aim of the study was to evaluate the microbiological and inflammatory outcomes 12-months after a 3-/7-day systemic antibiotic protocol [amoxicillin (AMX) + metronidazole (MET)] adjunctive to subgingival debridement in severe periodontitis compared to mechanical treatment alone." | 5.34 | Microbiological and host-derived biomarker evaluation following non-surgical periodontal therapy with short-term administration of systemic antimicrobials: secondary outcomes of an RCT. ( Arweiler, NB; Cosgarea, R; Eick, S; Heumann, C; Jepsen, S; Juncar, R; Salvi, GE; Sculean, A; Tristiu, R, 2020) |
| "Metronidazole loading was in the range of 0." | 5.34 | Chitosan inserts for periodontitis: influence of drug loading, plasticizer and crosslinking on in vitro metronidazole release. ( Anupurba, S; Barat, R; Mittal, N; Pandit, JK; Srinatha, A, 2007) |
| " We hypothesize, if variables fall below or exceed these threshold levels, systemic amoxicillin/metronidazole may contribute to reducing progression of periodontitis." | 5.30 | Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age: An exploratory sub-analysis of the ABPARO trial. ( Ehmke, B; Eickholz, P; Harks, I; Harmsen, D; Hoffmann, T; Kaner, D; Kim, TS; Koch, R; Kocher, T; Meyle, J; Schlagenhauf, U, 2019) |
| "Metronidazole was administered orally to four squirrel monkeys (100 mg/kg/bwt) for 17 days." | 5.27 | Effect of metronidazole on development of subgingival plaque and experimental periodontitis. ( Eisenberg, AD; Espeland, MA; Polson, AM; Zappa, UE, 1986) |
| "To evaluate the clinical outcomes 12 months after systemic administration of amoxicillin (AMX) and metronidazole (MET) adjunctive to subgingival debridement (SD) in patients with severe chronic periodontitis (sChP)." | 5.24 | One year results of a randomized controlled clinical study evaluating the effects of non-surgical periodontal therapy of chronic periodontitis in conjunction with three or seven days systemic administration of amoxicillin/metronidazole. ( Arweiler, NB; Cosgarea, R; Heumann, C; Juncar, R; Lascu, L; Salvi, GE; Sculean, A; Tristiu, R, 2017) |
| "Systemic amoxicillin-metronidazole was proven to be effective in managing periodontitis in systemically healthy patients." | 5.22 | Efficacy of Systemic Amoxicillin-Metronidazole in Periodontitis Patients with Diabetes Mellitus: A Systematic Review of Randomized Clinical Trials. ( Mugri, MH, 2022) |
| "The aim of this study was to assess the changes occurring in subgingival biofilm composition and in the periodontal clinical parameters of subjects with periodontitis and type 2 diabetes mellitus (DM) treated by means of scaling and root planing (SRP) only or combined with systemic metronidazole (MTZ) and amoxicillin (AMX)." | 5.22 | Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Maciel, SS; Miranda, TS; Tamashiro, NS, 2016) |
| " Eighty participants with Aggregatibacter actinomycetemcomitans-associated moderate to advanced periodontitis were randomized into two treatment groups: group A, antibiotics (500 mg metronidazole plus 375 mg amoxicillin three times per day for 7 days) during the first, non-surgical phase of periodontal therapy (T1) and placebo during the second, surgical phase (T2); and group B, placebo during T1 and antibiotics during T2." | 5.20 | Differential benefits of amoxicillin-metronidazole in different phases of periodontal therapy in a randomized controlled crossover clinical trial. ( Almaghlouth, A; Cionca, N; Courvoisier, DS; Giannopoulou, C; Mombelli, A, 2015) |
| "This paper aimed to study the effect of metronidazole sustained-release film combined with minocycline hydrochloride on treating periodontitis." | 5.20 | Clinical picture of combination therapy (metronidazole sustained release film with minocycine hydrochloride) in periodontitis. ( Yang, Z, 2015) |
| "This prospective, randomized, double-blind, placebo-controlled multi-centre trial comprising patients suffering from moderate to severe periodontitis evaluated the impact of rational adjunctive use of systemic amoxicillin 500 mg plus metronidazole 400 mg (3x/day, 7 days) on attachment loss." | 5.20 | Is progression of periodontitis relevantly influenced by systemic antibiotics? A clinical randomized trial. ( Doering, S; Ehmke, B; Eickholz, P; Gravemeier, M; Harks, I; Harmsen, D; Hoffmann, T; Holtfreter, B; Kaner, D; Kim, TS; Koch, R; Kocher, T; Meyle, J; Schlagenhauf, U, 2015) |
| "A total of 184 patients with moderate-to-severe periodontitis were randomly allocated to one of four treatment groups: 1) FDIS+metronidazole; 2) FDIS+placebo; 3) SRP+metronidazole; or 4) SRP+placebo." | 5.17 | A randomized, double-masked clinical trial comparing four periodontitis treatment strategies: 1-year clinical results. ( Baelum, V; Gjermo, P; Gunleiksrud, TM; Preus, HR; Sandvik, L, 2013) |
| "To compare the therapeutic effects of minocycline, metronidazole and iodine glycerin on periodontitis." | 5.14 | [Therapeutic effects of three topical remedies on periodontitis]. ( Fu, XY; Li, GF, 2010) |
| "To examine subgingival microbiological changes in chronic periodontitis subjects receiving scaling and root planing (SRP) alone or with systemically administered azithromycin, metronidazole or a sub-antimicrobial dose of doxycycline." | 5.13 | Microbiological changes associated with four different periodontal therapies for the treatment of chronic periodontitis. ( Haffajee, AD; Patel, M; Socransky, SS, 2008) |
| "The aim is to explore the optimal drug dose and duration of adjunctive Amoxicillin-plus-Metronidazole (AMX/MET) to full-mouth scaling and planing (FMSRP) in periodontitis." | 5.12 | The effect of drug dose and duration of adjuvant Amoxicillin-plus-Metronidazole to full-mouth scaling and root planing in periodontitis: a systematic review and meta-analysis. ( Hu, J; Zhao, H; Zhao, L, 2021) |
| "To evaluate and compare the effects of adjunctive metronidazole plus amoxicillin, doxycycline and metronidazole on clinical and microbiological parameters in patients with generalized aggressive periodontitis." | 5.12 | Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis. ( Baka, A; Konstantinidis, A; Sakellari, D; Slini, T; Xajigeorgiou, C, 2006) |
| " The purpose of this study was to evaluate the clinical effectiveness of chitosan, both as a carrier in gel form and as an active agent in the treatment of chronic periodontitis (CP)." | 5.12 | Application of chitosan gel in the treatment of chronic periodontitis. ( Akncbay, H; Ay, ZY; Senel, S, 2007) |
| "To determine the effect of metronidazole plus amoxicillin (M+A) as the sole therapy, on the subgingival microbiota of chronic periodontitis." | 5.12 | Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. ( Da Silva, I; Haffajee, AD; Japlit, MR; López, NJ; Socransky, SS, 2006) |
| "The aims of the present study were to evaluate the clinical efficacy of, and to monitor microbiologically, repeated oral hygiene instructions alone or in combination with metronidazole 25% gel or subgingival scaling with or without metronidazole gel in treatment of new, residual or recurrent periodontal pockets in previously treated adult periodontitis patients." | 5.12 | Repeated oral hygiene instructions alone, or in combination with metronidazole dental gel with or without subgingival scaling in adult periodontitis patients: a one-year clinical study. ( Corbet, EF; Lee, DH; Zee, KY, 2006) |
| "To compare clinical changes occurring in chronic periodontitis subjects receiving SRP alone or with systemically administered azithromycin, metronidazole or a sub-antimicrobial dose of doxycycline." | 5.12 | Clinical changes following four different periodontal therapies for the treatment of chronic periodontitis: 1-year results. ( Haffajee, AD; Socransky, SS; Torresyap, G, 2007) |
| "The objective of this study was to investigate the effect of the systemic administration of metronidazole and amoxicillin as an adjunct to initial periodontal therapy in patients with moderate to severe chronic periodontitis." | 5.12 | Adjunctive effects of systemic amoxicillin and metronidazole with scaling and root planing: a randomized, placebo controlled clinical trial. ( Fahami, N; Fallahzadeh, H; Haerian-ardakani, A; Moeintaghavi, A; Pakzad, A; Taghipour, S; Talebi-ardakani, MR; Zandi, H, 2007) |
| "Subgingival application of chlorhexidine via a controlled-delivery device (CHX chip) improves the clinical outcome of scaling/root planing (SRP) in therapy for chronic periodontitis." | 5.12 | Controlled-delivery chlorhexidine chip versus amoxicillin/metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis: a randomized controlled clinical trial. ( Bernimoulin, JP; Friedmann, A; Hopfenmüller, W; Kaner, D; Kleber, BM, 2007) |
| "The present controlled, single-blind study was performed to assess and compare the clinical healing and the microbiological findings following repeated intrasulcular applications of 1% metronidazole or 1% chlorhexidine gels in persistent periodontal pockets previously treated by scaling and root planing (SRP)." | 5.11 | Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients. ( Cordella, C; D'Ercole, S; Paolantonio, M; Perinetti, G; Piccolomini, R; Serra, E, 2004) |
| "The current investigation evaluated the clinical effects of scaling and root planing (SRP) alone or in combination with systemic metronidazole and/or repeated professional removal of supragingival plaque in subjects with chronic periodontitis." | 5.11 | Scaling and root planing, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population. I. clinical results. ( Carvalho, LH; D'Avila, GB; Feres, M; Haffajee, AD; Leão, A; Socransky, SS, 2004) |
| "Previous studies have shown that metronidazole, alone or in combination with spiramycin (250 mg/1 500 000 units, three times/day), is an effective treatment for active periodontitis, although the dose of metronidazole currently used (750 mg/day) could provide concentrations in gingival crevice fluid that are too low for the MICs of the involved pathogens." | 5.11 | Concentrations and in vivo antibacterial activity of spiramycin and metronidazole in patients with periodontitis treated with high-dose metronidazole and the spiramycin/metronidazole combination. ( Barthet, P; Brumpt, I; Duffaut, D; Poulet, PP, 2005) |
| "The current investigation evaluated changes in levels and proportions of 39 bacterial species in subgingival plaque samples after scaling and root planing (SRP) alone or in combination with systemic metronidazole and/or professional cleaning in subjects with chronic periodontitis." | 5.11 | Scaling and root planing, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population II--microbiological results. ( Carvalho, LH; D'Avila, GB; Feres, M; Gonçalves, C; Haffajee, AD; Leão, A; Socransky, SS, 2005) |
| "Patients with previously untreated chronic periodontitis and subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to subgingival scaling without (control group) or with systemic amoxicillin plus metronidazole and CHX irrigation (test group)." | 5.11 | Adjunctive antimicrobial therapy of periodontitis: long-term effects on disease progression and oral colonization. ( Beikler, T; Ehmke, B; Flemmig, TF; Milian, E; Moter, A, 2005) |
| "The objective of this study was to assess the adjunctive clinical effect of the administration of systemic amoxicillin and metronidazole in the non-surgical treatment of generalized aggressive periodontitis (GAP)." | 5.11 | Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial. ( Griffiths, GS; Guerrero, A; Laurell, L; Moles, DR; Nibali, L; Suvan, J; Tonetti, MS, 2005) |
| "The purpose of the present investigation was to determine the percentage and identity of antibiotic-resistant species in subgingival plaque and saliva samples from chronic periodontitis patients treated by scaling and root planing followed by orally administered amoxicillin or metronidazole." | 5.10 | Antibiotic resistance of subgingival species during and after antibiotic therapy. ( Allard, K; Feres, M; Goodson, JM; Haffajee, AD; Socransky, SS; Som, S, 2002) |
| " Adjunctive metronidazole therapy did not improve pregnancy outcome." | 5.10 | Periodontal disease and preterm birth: results of a pilot intervention study. ( Cliver, SP; Geurs, NC; Goldenberg, RL; Hauth, JC; Hodgkins, PM; Jeffcoat, MK; Reddy, MS, 2003) |
| "The aim of the present study was to evaluate the clinical and microbiological effects of subgingival application of 25% metronidazole dental gel as an adjunct to scaling and root planing (SRP) in the treatment of adult periodontitis." | 5.09 | Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis; 12-months results. ( Bilgiç, A; Buduneli, E; Evrenosoglu, E; Tünger, A, 2001) |
| "The effect of topical application of a metronidazole gel (ELYZOL DENTAL GEL), and adjunctive therapy in the treatment of adult periodontitis was assessed clinically." | 5.09 | Clinical evaluation of subgingival application of metronidazole 25%, and adjunctive therapy. ( Al-Mubarak, SA; Ho, A; Karring, T, 2000) |
| "A single-blind, randomised clinical trial of 28 smokers and 56 non-smokers, stratified for periodontitis disease severity and randomly allocated to 3 treatment groups: (1) Scaling and root planing using an ultrasonic scaler with local anaesthesia (SRP), (2) SRP+ metronidazole tabs 200 mg tds for 7 days, (3) SRP + 2 subgingival applications of 25% metronidazole gel." | 5.09 | Non-surgical periodontal treatment with and without adjunctive metronidazole in smokers and non-smokers. ( Matthews, JP; Palmer, RM; Wilson, RF, 1999) |
| "The aim of this study was to examine the effect of periodontal surgery on PGE2 levels in patients treated for advanced adult periodontitis, with and without application of a 25% metronidazole gel over 12 months follow-up." | 5.09 | Periodontal flap surgery with 25% metronidazole gel. (2). Effect on gingival crevicular fluid PGE2. ( Collins, AM; Moles, DR; Needleman, IG, 2000) |
| "The aim of this double-blind, parallel study was to evaluate the adjunctive effects of systemically administered amoxicillin and metronidazole in a group of adult periodontitis patients who also received supra- and subgingival debridement." | 5.09 | Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. ( Timmerman, MF; Van der Velden, U; Van der Weijden, GA; Van Winkelhoff, AJ; Winkel, EG, 2001) |
| "The aim of this study was to examine the effect of doxycycline, metronidazole, and clindamycin used adjunctively in a 2-step nonsurgical procedure in patients with rapidly progressive periodontitis (RPP)." | 5.09 | A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis. ( Beier, M; Glockmann, E; Klinger, G; Pfister, W; Sigusch, B, 2001) |
| "In this article the clinical and microbiological effects of systemic metronidazole in the treatment of refractory periodontitis in adult patients is discussed." | 5.09 | [Metronidazole in the treatment of refractory periodontitis]. ( van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 2000) |
| "The present study describes results on selected clinical and microbiological parameters obtained by treatment with local (Elyzol) and systemic (Flagyl) use of metronidazole alone and/or mechanical subgingival debridement in adult periodontitis." | 5.08 | A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients. ( Acar, O; Büget, E; Kadir, T; Kuru, B; Noyan, U; Yilmaz, S, 1997) |
| "The Effect on the subgingival microflora of a single topical administration of a 95% collagen and 5% metronidazole device in combination with debridement was investigated in 30 adult periodontitis patients in comparison with mechanical treatment alone." | 5.08 | Effects of combined topical metronidazole and mechanical treatment on the subgingival flora in deep periodontal pockets in cuspids and bicuspids. ( Bitton, C; Charbit, Y; Fosse, T; Hannoun, L; Hitzig, C, 1997) |
| "48 adult patients with untreated periodontitis harboring subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis were randomly assigned to receive full mouth scaling alone (control) or scaling with systemic metronidazole plus amoxicillin and supragingivai irrigation with chlorhexidine digluconate (test)." | 5.08 | Differential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats. ( Flemmig, TF; Karch, H; Klaiber, B; Kopp, C; Milián, E, 1998) |
| "The present study describes selected clinical and microbiological results obtained by treatment with local (Elyzol) and systemic (Flagyl) use of metronidazole alone and/or mechanical subgingival debridement in early onset periodontitis (EOP)." | 5.08 | A clinical and microbiological evaluation of systemic and local metronidazole delivery in early onset periodontitis patients. ( Acar, O; Büget, E; Kadir, T; Kuru, B; Noyan, U; Yilmaz, S, 1996) |
| "Fifty-two adult periodontitis patients were treated by the tablets of tinidazole (TNZ), and 23 patients treated by metronidazole (MNZ) served as control group." | 5.08 | [The effect of tinidazole in the treatment of adult periodontitis]. ( Chen, L; Ni, K; Wang, R, 1996) |
| "48 adult patients with untreated periodontitis harboring subgingival Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis as assessed by PCR were randomly assigned to receive full-mouth scaling alone (control) or scaling with systemic metronidazole plus amoxicillin and supragingival irrigation with chlorhexidine digluconate (test)." | 5.08 | Differential clinical treatment outcome after systemic metronidazole and amoxicillin in patients harboring Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis. ( Flemmig, TF; Karch, H; Klaiber, B; Milián, E, 1998) |
| "To compare clinical and microbiological responses following non-surgical treatment of moderate to advanced adult periodontitis using subgingival scaling with and without adjunctive topical or systemic metronidazole." | 5.08 | Adjunctive systemic and locally delivered metronidazole in the treatment of periodontitis: a controlled clinical study. ( Matthews, JP; Palmer, RM; Wilson, RF, 1998) |
| "The present study was performed to assess and compare the clinical healing and the microbiological findings following local application of metronidazole or tetracycline to augment subgingival scaling in previously untreated adult periodontitis sites." | 5.08 | Effects of topical metronidazole and tetracycline in treatment of adult periodontitis. ( Böe, OE; Bruun, G; Lie, T, 1998) |
| "A randomized, double-blind, clinical study was done to assess the microbiological and clinical effects of metronidazole plus amoxicillin (M+A) as the only therapy in 46 patients with moderate to advanced progressive adult periodontitis." | 5.08 | Effects of metronidazole plus amoxicillin in progressive untreated adult periodontitis: results of a single 1-week course after 2 and 4 months. ( Gamonal, JA; López, NJ, 1998) |
| "In this study, we evaluated the microbiological and clinical effects of mechanical debridement in combination with metronidazole and amoxicillin therapy in 48 patients with Actinobacillus actinomycetemcomitans-associated periodontitis, 3 months and at least 24 months after active treatment." | 5.07 | Microbiological and clinical effects of metronidazole and amoxicillin in Actinobacillus actinomycetemcomitans-associated periodontitis. A 2-year evaluation. ( de Graaff, J; Douqué, NH; Pavicić, MJ; Steures, RW; van Winkelhoff, AJ, 1994) |
| "The purpose of this study was to evaluate the clinical effects of a single application of a 5% metronidazole collagen device in periodontal pockets deeper than 5 mm, in association with debridement and without reinforcement of home care and hygiene as practiced by the patient at any time." | 5.07 | Topical metronidazole as an adjunct to subgingival debridement in the treatment of chronic periodontitis. ( Bitton, C; Charbit, Y; Fosse, T; Hannoun, L; Hitzig, C; Teboul, M; Varonne, R, 1994) |
| "The aim of the study was to compare the clinical and microbiological effects of topical application of a metronidazole gel and a single session of subgingival scaling in the treatment of adult periodontitis." | 5.07 | Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. ( Karring, T; Kilian, M; Pedrazzoli, V, 1992) |
| "This report presents the findings from an open randomized multicentre clinical trial designed to compare the clinical efficacy of scaling with application of 3 different preparations/dose frequencies of topical metronidazole in the treatment of adult periodontitis." | 5.07 | 3 regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults. ( Attström, R; Karring, T; Kisch, J; Klinge, B; Lewin, B; Stoltze, K, 1992) |
| "A newly developed metronidazole 25% dental gel was compared with subgingival scaling in the treatment of adult periodontitis." | 5.07 | Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. ( Ainamo, J; Ellingsen, BH; Hansen, BF; Johansson, LA; Karring, T; Kisch, J; Lie, T; Paunio, K; Stoltze, K, 1992) |
| "The efficacy of metronidazole and doxycycline in preventing recurrent periodontitis was studied in 23 patients." | 5.07 | Serial doxycycline and metronidazole in prevention of recurrent periodontitis in high-risk patients. ( Aitken, S; Birek, P; Kulkarni, GV; Lee, WL; McCulloch, CA, 1992) |
| "The effect of adjunctive systemic metronidazole was studied in patients with moderate and advanced periodontitis recalcitrant to comprehensive non-surgical treatment." | 5.06 | The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults. ( Engström, PE; Frithiof, L; Nedlich, U; Rubin, B; Söder, B; Söder, PO; Wikner, S; Wouters, F, 1990) |
| "The influence of a systemic metronidazole therapy in case of marked marginal periodontitis on clinical parameter and the subjective pocket flora was examined." | 5.06 | [Influence of systemic metronidazole therapy on the flora of the periodontal gingival pocket]. ( Gäbler, K, 1989) |
| "This double-blind cross-over study was undertaken to assess the effect of systemically administered metronidazole when used as an adjunct to periodontal surgery for the treatment of moderate and advanced periodontitis." | 5.06 | The value of systemically administered metronidazole in the modified Widman flap procedure. ( Dolby, AE; Mahmood, MM, 1987) |
| "The effect of metronidazole was assessed in 20 subjects with untreated periodontitis, in a double-blind trial." | 5.06 | Metronidazole: a double-blind trial in untreated human periodontal disease. ( Floyd, P; Palmer, R; Watts, T, 1986) |
| "This systematic review aimed to determine the optimum dose and duration of amoxicillin-plus-metronidazole prescribed as an adjunct to non-surgical treatment of periodontitis." | 4.98 | Optimal dose and duration of amoxicillin-plus-metronidazole as an adjunct to non-surgical periodontal therapy: A systematic review and meta-analysis of randomized, placebo-controlled trials. ( Ivanovski, S; McGowan, K; McGowan, T, 2018) |
| "Meta-analysis was used to assess the effectiveness of local delivery of metronidazole alone or as an adjunct to mechanical therapy in patients with chronic periodontitis." | 4.82 | Meta-analysis of local metronidazole in the treatment of chronic periodontitis. ( Angelillo, IF; Bianco, A; Nobile, CG; Pavia, M, 2004) |
| "Controlled release devices containing tetracyclines or metronidazole are now commercially available for use in periodontal pockets." | 4.79 | The role of antibiotics in the treatment of periodontitis. (Part I--Systemic delivery. ( Foyle, DM; Needleman, IG; Pandya, NV; Smith, SR, 1994) |
| "The purpose of this meta-analysis was to provide a quantitative overview of clinical trials assessing the use of systemic metronidazole (S-MET) as an adjunct to scaling and root planning (S&RP) in the treatment of adult periodontitis." | 4.79 | Meta-analysis of the effect of systemic metronidazole as an adjunct to scaling and root planing for adult periodontitis. ( Beck, JD; Elter, JR; Lawrence, HP; Offenbacher, S, 1997) |
| "The aim of the present study was to prepare resorbable polylactide fibers for periodontitis treatment using coaxial electrospinning to optimize the release of metronidazole (MNA) by reducing the initial burst effect." | 4.31 | Coaxial electrospun nanofibers as drug delivery system for local treatment of periodontitis. ( Guellmar, A; Heyder, M; Jurke, A; Kranz, S; Reise, M; Rosenbaum, T; Schnabelrauch, M; Sigusch, BW; Watts, DC; Weisser, J; Wyrwa, R, 2023) |
| "This study aimed to investigate the influence of smoking on clinical, microbiological and immunological parameters in young adult with stage III-IV Grade C periodontitis after full-mouth ultrasonic debridement (FMUD) associated with Amoxicillin and Metronidazole (AMX + MTZ), comparing smokers (PerioC-Y-Smk) with non-smokers (PerioC-Y-NSmk)." | 4.12 | Smoking negatively impacts the clinical, microbiological, and immunological treatment response of young adults with Grade C periodontitis. ( Casarin, RCV; Casati, MZ; Corrêa, MG; da Silva, RVC; de Freitas Monteiro, M; Rangel, TP; Ruiz, KG; Sallum, AW; Sallum, EA, 2022) |
| "Mechanical treatment associated with metronidazole and amoxicillin promoted a beneficial change in the microbiome of young individuals with severe periodontitis." | 4.02 | Microbiome changes in young periodontitis patients treated with adjunctive metronidazole and amoxicillin. ( Bittinger, K; Faveri, M; Feres, M; Fermiano, D; Figueiredo, LC; Lee, JJ; Mayer, MPA; Retamal-Valdes, B; Teles, F, 2021) |
| "The aim of this follow-up study was, to compare the effects of mechanical periodontal therapy with or without adjunctive amoxicillin and metronidazole on the subgingival microbiome of smokers with periodontitis using 16S rDNA amplicon next generation sequencing." | 3.96 | Significant Short-Term Shifts in the Microbiomes of Smokers With Periodontitis After Periodontal Therapy With Amoxicillin & Metronidazole as Revealed by 16S rDNA Amplicon Next Generation Sequencing. ( Ehmke, B; Eickholz, P; Hagenfeld, D; Harks, I; Harmsen, D; Kaner, D; Kim, TS; Kocher, T; Lorenz, K; Matern, J; Meyle, J; Prior, K; Schlagenhauf, U, 2020) |
| "Twenty (20) patients with severe periodontitis underwent a single session of One-Stage Full-Mouth Instrumentation (OSFMI) involving supra- and sub-gingival air-polishing with erythritol and chlorhexidine powder and ultrasonic root surface debridement and calculus removal, in association with systemic amoxicillin and metronidazole." | 3.96 | One-Stage Full Mouth Instrumentation (OSFMI): Clinical Outcomes of an Innovative Protocol for the Treatment of Severe Periodontitis. ( Calza, S; Feres, M; Garzetti, G; Mensi, M; Scotti, E; Sordillo, A, 2020) |
| "This study aimed to develop pH-responsive polylactide-glycolic acid co-polymer and chitosan (PLGA/chitosan) nanosphere as an inflammation-responsive vehicle and evaluate the potential of the nanosphere encapsulating metronidazole, an antibiotic, and N-phenacylthiazolium bromide (PTB), a host modulator, for treating periodontitis." | 3.88 | Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide. ( Chang, PC; Feng, F; Lin, JH; Wang, CH; Yu, MC, 2018) |
| "To evaluate if non-diabetic subjects with periodontitis respond better than subjects with type 2 diabetes to the treatment protocol of scaling and root planing (SRP), metronidazole (MTZ) and amoxicillin (AMX)." | 3.88 | Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study. ( Duarte, PM; Faveri, M; Feres, M; Figueiredo, LC; Miranda, TS; Retamal-Valdes, B; Soares, GMS; Yassine, LLS, 2018) |
| "Metronidazole (MZ) and levofloxacin (LF) are widely employed for treatment of periodontitis, but high oral dose and resistance development after long-term oral administration limit their use." | 3.83 | Development and Evaluation of Biodegradable Chitosan Films of Metronidazole and Levofloxacin for the Management of Periodontitis. ( Bansal, M; Khan, G; Mishra, B; Nath, G; Patel, RR; Yadav, SK, 2016) |
| "The effect of a drug-delivery system containing antibacterial metronidazole (MDZ) prescribed for periodontitis on supragingival biofilm was evaluated, and possible interference by this biofilm in the drug release profile was investigated." | 3.83 | Local antibiotic delivery in periodontitis: drug release and its effect on supragingival biofilms. ( Aires, CP; Ferreira, MP; Freitas, O; Ré, AC, 2016) |
| "Aggregatibacter (Actinobacillus) actinomycetemcomitans, Prevotella intermedia/nigrescens, Fusobacterium nucleatum and Eikenella corrodens from our strain collection and subgingival bacteria isolated from patients with periodontitis were tested for their susceptibility to amoxicillin and metronidazole using the Etest." | 3.80 | Combinatorial effects of amoxicillin and metronidazole on selected periodontal bacteria and whole plaque samples. ( Kulik Kunz, EM; Lenkeit, K; Walter, C; Waltimo, T; Weiger, R, 2014) |
| "We aimed to achieve detailed biomaterials characterization of a drug delivery system for local periodontitis treatment based on electrospun metronidazole-loaded resorbable polylactide (PLA) fibers." | 3.78 | Release of metronidazole from electrospun poly(L-lactide-co-D/L-lactide) fibers for local periodontitis treatment. ( Berg, A; Jandt, KD; Müller, U; Reise, M; Schnabelrauch, M; Sigusch, BW; Völpel, A; Watts, DC; Wyrwa, R; Zylinski, M, 2012) |
| "The purpose of this study is to formulate in situ implants containing doxycycline hydrochloride and/or secnidazole that could be used in the treatment of periodontitis by direct periodontal intrapocket administration." | 3.74 | Formulation and evaluation of PLA and PLGA in situ implants containing secnidazole and/or doxycycline for treatment of periodontitis. ( Abd El-Hady, SS; El-Nabarawi, MA; Gad, HA, 2008) |
| " The purpose of this study is to formulate gels containing secnidazole or doxycycline hydrochloride that could be used in the treatment of periodontitis by direct periodontal intrapocket administration." | 3.74 | Formulation and evaluation of secnidazole or doxycycline dento-oral gels. ( Abd el-Hady, SS; el-Nabarawi, MA; Gad, HA, 2008) |
| "The objective of this study was to explore the effect of incomplete adherence to the prescribed antibiotic regimen, amoxicillin and metronidazole, in the non-surgical treatment of generalized aggressive periodontitis (GAP)." | 3.74 | Incomplete adherence to an adjunctive systemic antibiotic regimen decreases clinical outcomes in generalized aggressive periodontitis patients: a pilot retrospective study. ( Echeverría, JJ; Guerrero, A; Tonetti, MS, 2007) |
| " Systemic administration of combinations of metronidazole and either amoxicillin or ciprofloxacin has been widely used with great success; however the presence of subgingival yeasts and resistant bacteria can be a problem in some periodontitis patients." | 3.73 | Periodontal antimicrobials--finding the right solutions. ( Aalam, A; Jorgensen, MG; Slots, J, 2005) |
| "The effects of dicloran gel in combination with antibiotics on salivary lipid peroxidation were evaluated in 18 patients aged 23-68 years with chronic generalized rapidly progressing periodontitis." | 3.71 | [Relationship between salivary lipid peroxidation and the strategy of local dichloran gel treatment for periodontitis]. ( Grudianov, AI; Ovchinnikova, VV; Serebriakova, LE, 2002) |
| "This study was designed to evaluate the clinical effects of metronidazole ofloxacin gel (MO gel) as an adjunct to conventional therapy for periodontitis." | 3.71 | [Clinical effects of metronidazole-ofloxacin gel as an adjunct to conventional therapy for periodontitis]. ( Wang, X; Xu, Y; Yang, H; Zhang, J, 2001) |
| "After baseline clinical and microbiological monitoring, 17 adult periodontitis subjects received full mouth SRP and 14 days systemic administration of either metronidazole (250 mg, TID, n=8) or amoxicillin (500 mg, TID, n=9)." | 3.71 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. ( Allard, K; Feres, M; Haffajee, AD; Socransky, SS; Som, S, 2001) |
| " actinomycetemcomitans-associated periodontitis during successive non-surgical and adjunctive metronidazole plus amoxicillin (or ciprofloxacin) (AB) therapy." | 3.70 | Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis. ( Borneff, M; Heinecke, A; Kiencke, C; Knopf, A; Müller, HP; Pohl, S, 1998) |
| " The findings from antibiotic susceptibility test showed that high number of bacteria associated with refractory periodontitis resulted resistant to erythromycin, metronidazole and tetracycline." | 3.70 | Microbiotica associated with refractory periodontis. Prevalence and antibiotic susceptibility. ( Barone, A; Ciaglia, RN; Ramaglia, L; Sbordone, L, 1999) |
| "Elyzo 25% Dentalgel (EDG) which is developed for use in the treatment of periodontitis is a suspension of metronidazole benzoate (40%) in a mixture of glyceryl mono-oleate (GMO) and triglyceride (sesame oil)." | 3.69 | Elimination of Elyzol 25% Dentalgel matrix from periodontal pockets. ( Stoltze, K, 1995) |
| "The peripheral distribution of spiramycin and metronidazole, which are combined in the proprietary drug "Rodogyl", has been studied in gingival fluid, saliva and blood after a single administration to 12 healthy volunteers and after repeated administration to 4 patients with recurring severe periodontitis." | 3.69 | Kinetics of spiramycin/metronidazole (Rodogyl) in human gingival crevicular fluid, saliva and blood. ( Cimasoni, G; Le Liboux, A; Pichard, E; Rotzetter, PA, 1994) |
| "The aim of the present study was to monitor the microbiological and clinical effects of renewed supra- and subgingival debridement in conjunction with systemic metronidazole therapy (500 mg TID for 7 days) in 27 "refractory" periodontitis patients, culture positive for Bacteroides forsythus and negative for Actinobacillus actinomycetemcomitans." | 3.69 | Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus. ( Timmerman, MF; Van der Velden, U; Van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 1997) |
| "We report on the microbiological and clinical effects of mechanical debridement in combination with metronidazole plus amoxicillin therapy in 118 patients with Actinobacillus actinomycetemcomitans-associated periodontitis." | 3.68 | Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis. ( de Graaff, J; Tijhof, CJ; van Winkelhoff, AJ, 1992) |
| "Systemic absorption of metronidazole was studied after one application of a metronidazole 25% dental gel into inflamed periodontal pockets." | 3.68 | Systemic absorption of metronidazole after application of a metronidazole 25% dental gel. ( Stellfeld, M; Stoltze, K, 1992) |
| "The present study was performed to assess the effect of topical metronidazole therapy on ligature-induced periodontitis in beagle dogs." | 3.68 | The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog. ( Attström, R; Edwardsson, S; Kalfas, S; Klinge, B; Kuvatanasuhati, J, 1992) |
| "This study investigated the effects of root planing and/or the placement of acrylic strips containing chlorhexidine, metronidazole or tetracycline on the composition and antimicrobial susceptibility of the subgingival flora in chronic periodontitis." | 3.68 | The effects of antimicrobial acrylic strips on the subgingival microflora in chronic periodontitis. ( Addy, M; Moran, J; Morgan, JR; Newcombe, R; Wade, WG, 1992) |
| "Systemic administration of metronidazole during an experimental periodontitis resulted in significantly less active tissue destruction compared to drug-free animals." | 3.68 | Effect of metronidazole on experimental periodontitis: cell population characteristics. ( Espeland, MA; Polson, AM; Zappa, UE, 1992) |
| " This study attempts to measure changes in flora by a number of methods following the placement of 40% metronidazole acrylic strips into periodontal pockets." | 3.67 | Simple bacteriological methods to assess changes in subgingival microflora produced by metronidazole-containing acrylic strips placed into periodontal pockets. ( Addy, M; Alam, L; Rawle, L, 1984) |
| "5%) and the other high (40%) dose metronidazole locally in periodontal pockets once a week for 4 weeks." | 3.67 | Slow release metronidazole and a simplified mechanical oral hygiene regimen in the control of chronic periodontitis. ( Addy, M; Newman, HN; wan Yusof, WZ; Yeung, FI, 1984) |
| "5% metronidazole solutions on the clinical and microbiologic parameters of adult periodontitis as compared with scaling and root planing." | 3.67 | Clinical and microbiologic changes following the irrigation of periodontal pockets with metronidazole or stannous fluoride. ( Bissada, NF; Lazzaro, AJ, 1989) |
| "The present study evaluated the effect of systemic metronidazole on advanced periodontitis in 10 patients with inadequate oral hygiene." | 3.67 | Systemic metronidazole in the treatment of periodontitis. ( Gilmour, WH; Jenkins, WM; MacFarlane, TW; MacKenzie, D; Ramsay, I, 1989) |
| "The aim of this study was to evaluate the effects of a gel containing 4% metronidazole and collagen in periodontal pockets deeper than 4 mm." | 3.67 | [Experimental study of a metronidazole gel inserted in periodontal pockets]. ( Bitton-Sebag, C; Charbit, Y; Hitzig, C; Lapougeas, JC; Teboul, M, 1989) |
| "The potential use of an adjunctive therapy of metronidazole plus amoxycillin for the subgingival elimination of Actinobacillus actinomycetemcomitans in periodontitis patients was investigated." | 3.67 | Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis. ( Abbas, F; de Graaff, J; Goené, RJ; Rodenburg, JP; van Winkelhoff, AJ; Winkel, EG, 1989) |
| "Niridazole, metronidazole and tetracycline were compared for their activity against subgingival bacteria from patients with chronic periodontitis." | 3.67 | Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis. ( Addy, M; Wade, WG, 1987) |
| "Sites affected with adult periodontitis were observed for 3 months to compare their clinical and microbiologic responses to a single 2 g dose of metronidazole, scaling and root planing, or no treatment." | 3.67 | Clinical and microbiologic effects of single-dose metronidazole or scaling and root planing in treatment of adult periodontitis. ( Armitage, GC; Buchanan, SA; Hoover, CI; Newbrun, E; Robertson, PB; Taggart, EJ; Walsh, MM, 1986) |
| " Two double blind studies are reviewed which indicate that metronidazole plus mechanical debridement of the root surfaces is significantly better than placebo plus mechanical debridement in the treatment of advanced cases of periodontitis especially when the periodontal pockets are 6 mm or more in depth." | 3.67 | The therapeutic use of antimicrobial agents in patients with periodontal disease. ( Loesche, WJ, 1985) |
| "To explore the efficacy and safety of ornidazole combined with periodontal tissue regeneration in the treatment of periodontitis." | 2.94 | [Study on the efficacy and safety of metronidazole combined with periodontal tissue regeneration in the treatment of periodontitis]. ( DA, Y; Wang, MJ; Zheng, LC, 2020) |
| "The formulated SLMs gel offers an applicable dosage form that can be injected directly into the periodontal pocket as adjunctive to scaling and root planing." | 2.84 | Doxycycline hydrochloride-metronidazole solid lipid microparticles gels for treatment of periodontitis: development, in-vitro and in-vivo clinical evaluation. ( El Dessouky, HF; Ezzat, OM; Gad, HA; Kamel, AO; Sammour, OA, 2017) |
| "Tooth loss is the ultimate negative consequence of periodontitis, and reports of the extent to which different treatment strategies may influence long-term tooth loss are hard to find." | 2.84 | A Randomized Double-Masked Clinical Trial Comparing Four Periodontitis Treatment Strategies: 5-Year Tooth Loss Results. ( Baelum, V; Gjermo, P; Preus, HR, 2017) |
| "Erythromycin resistance was high at baseline and remained unchanged throughout the study." | 2.82 | Effect of Periodontal Therapy With Amoxicillin-Metronidazole on Pharyngeal Carriage of Penicillin- and Erythromycin-Resistant Viridans Streptococci. ( Almaghlouth, A; Cherkaoui, A; Cionca, N; Giannopoulou, C; Mombelli, A; Schrenzel, J, 2016) |
| "In this study, periodontal disease progression was successfully arrested in 95% of the initially compromised lesions, while 2% to 5% experienced discrete or recurrent episodes of loss of periodontal support." | 2.70 | Aggressive periodontitis: 5-year follow-up of treatment. ( Buchmann, R; Lange, DE; Nunn, ME; Van Dyke, TE, 2002) |
| "Twenty adult patients with untreated periodontitis and subgingival colonization of A." | 2.69 | Clonal infection with Actinobacillus actinomycetemcomitans following periodontal therapy. ( Beikler, T; Ehmke, B; Flemmig, TF; Karch, H; Klaiber, B; Kopp, C; Schmidt, H, 1999) |
| "Thirty-four adult patients with untreated periodontitis were randomly assigned to receive full mouth scaling alone or scaling with an adjunctive antimicrobial therapy, both followed by supportive periodontal therapy." | 2.69 | Protective effect of serum antibodies against a 110-kilodalton protein of Actinobacillus actinomycetemcomitans following periodontal therapy. ( Beikler, T; Ehmke, B; Flemmig, TF; Karch, H; Klaiber, B, 1999) |
| "Metronidazole is an agent with reported success in the treatment of anaerobic periodontal infections." | 2.67 | Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters. ( Giordano, J; Grossman, N; Loesche, WJ, 1993) |
| "Periodontitis is one of the most prevalent inflammatory diseases in humans." | 2.66 | Antimicrobial photodynamic therapy compared to systemic antibiotic therapy in non-surgical treatment of periodontitis: Systematic review and meta-analysis. ( da Rocha, TE; Ervolino, E; Garcia, VG; Guiati, IZ; Souza, EQM; Theodoro, LH; Toro, LF; Wainwright, M, 2020) |
| "Necrotizing periodontitis is an extension of NG into the periodontal attachment apparatus, and the two stages are referred to collectively as necrotizing periodontal diseases (NPD)." | 2.44 | Necrotizing periodontal diseases in HIV-seropositive subjects: pathogenic mechanisms. ( Feller, L; Lemmer, J, 2008) |
| "Chronic periodontitis affects many adults in the United States, some severely enough to threaten tooth loss." | 2.43 | Impact of local adjuncts to scaling and root planing in periodontal disease therapy: a systematic review. ( Bonito, AJ; Lohr, KN; Lux, L, 2005) |
| "The main goal in the treatment of periodontitis is to control the subgingival infection." | 2.40 | Systemic antibiotic therapy in severe periodontitis. ( van Winkelhoff, AJ; Winkel, EG, 1997) |
| "Periodontitis is a bacterial infection." | 2.40 | Chemical treatment of periodontitis: local delivery of antimicrobials. ( Killoy, WJ, 1998) |
| " However, there are reasons to suggest that local delivery of metronidazole should not be used as a substitute for conventional treatment of periodontal disease, since side-effects of long-term use and repeated use are not known." | 2.40 | The use of locally delivered metronidazole in the treatment of periodontitis. Clinical results. ( Magnusson, I, 1998) |
| "Periodontitis is a result of an infection with specific pathogenic microorganisms." | 2.40 | Local delivery of antimicrobial agents for the treatment of periodontitis. ( Magnusson, I, 1998) |
| " This article aims to review the "additional" effect of a subgingival irrigation with chlorhexidine, or a local or systemic application of tetracycline or metronidazole, performed in combination with a single course of scaling and root planing in patients with chronic adult periodontitis." | 2.39 | Microbiological response to mechanical treatment in combination with adjunctive therapy. A review of the literature. ( Bollen, CM; Quirynen, M, 1996) |
| " Review of the drug's pharmacology and potential side effects indicate that it poses little threat to humans of inducing acute toxicity, mutagenesis, or cancer if used according to recommended dosing regimens." | 2.38 | The role of metronidazole in the treatment of periodontal diseases. ( Greenstein, G, 1993) |
| "Periodontitis is associated with microflorae which may consist of indigenous, exogenous or superinfecting organisms." | 2.38 | Antimicrobial therapy in periodontics. ( Slots, J; van Winkelhoff, AJ, 1993) |
| "Metronidazole has important interactions with alcohol, disulfiram and warfarin and there are contraindications to its use." | 2.37 | Metronidazole: its use in clinical dentistry. ( Mitchell, DA, 1984) |
| "Periodontal diseases are common oral diseases that afflict all humans to some degree." | 2.37 | Current concepts in periodontal diseases. ( Higgins, TJ; Hunter, N; Knox, KW, 1985) |
| "Periodontitis is a chronic inflammatory disease that leads to the loss of alveolar bone, among several studies focusing on reconstructing periodontal bone caused by periodontitis, guided bone regeneration (GBR) is a promising approach." | 1.91 | Comprehensive reparative effects of bacteriostatic poly(L-lactide-co-glycolide)/poly(L-lactide-co-ε-caprolactone) electrospinning membrane on alveolar bone defects in progressive periodontitis. ( Han, M; Liu, Y; Mi, F; Wang, B; Zhao, Y; Zhu, W, 2023) |
| "Likewise, all three therapies attenuated alveolar bone loss." | 1.51 | Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss. ( Bull, J; Ebbers, MNB; Engelmann, R; Kneitz, S; Kreikemeyer, B; Lang, H; Lübcke, PM; Müller-Hilke, B; Volzke, J, 2019) |
| "Caries/pulpitis was the most common diagnosis (n = 222; 31% of cases), of which 48 (21%) were prescribed antibiotics." | 1.42 | Diagnosis and prescribing pattern of antibiotics and painkillers among dentists. ( Lundborg, CS; Marrone, G; Tanwir, F; Tariq, A, 2015) |
| "Periodontitis is the primary cause of tooth loss in adults and a very wide-spread disease." | 1.42 | In-situ forming composite implants for periodontitis treatment: How the formulation determines system performance. ( Delcourt, E; Do, MP; Mäder, K; Metz, H; Neut, C; Siepmann, F; Siepmann, J, 2015) |
| "Some subjects with untreated periodontitis exhibit elevated levels of distinct inflammatory markers in serum." | 1.40 | Effect of periodontal treatment on peak serum levels of inflammatory markers. ( Almaghlouth, AA; Cancela, JA; Cionca, N; Courvoisier, DS; Décaillet, F; Giannopoulou, C; Mombelli, A, 2014) |
| "This approach could be used to treat recurrent periodontitis or other diseases caused by intracellular-dwelling organisms." | 1.39 | Polymersome-mediated intracellular delivery of antibiotics to treat Porphyromonas gingivalis-infected oral epithelial cells. ( Armes, SP; Battaglia, G; Douglas, CW; Lewis, AL; Murdoch, C; Pinnock, A; Thornhill, MH; Warren, NJ; Wayakanon, K, 2013) |
| "Although polymicrobial infections, such as peri-implantitis or periodontitis, were postulated in the literature to be caused by synergistic effects of bacteria, these effects remain unclear looking at antibiotic susceptibility." | 1.37 | Antibiotic susceptibility of cocultures in polymicrobial infections such as peri-implantitis or periodontitis: an in vitro model. ( Al-Nawas, B; d'Hoedt, B; Karbach, J; Mouratidou, A, 2011) |
| "Oxantel was more effective against P." | 1.36 | Inhibition of Porphyromonas gingivalis biofilm by oxantel. ( Ang, CS; Dashper, S; Liu, SW; Paolini, R; Reynolds, E; Veith, P, 2010) |
| "Metronidazole (MTZ) is a widely used antimicrobial agent." | 1.36 | Effect of metronidazole and modulation of cytokine production on human periodontal ligament cells. ( Annunziata, M; Bevilacqua, N; Guida, L; Paolillo, R; Rizzo, A; Tufano, MA, 2010) |
| "Metronidazole loading was in the range of 0." | 1.34 | Chitosan inserts for periodontitis: influence of drug loading, plasticizer and crosslinking on in vitro metronidazole release. ( Anupurba, S; Barat, R; Mittal, N; Pandit, JK; Srinatha, A, 2007) |
| "Periodontitis is a well-appreciated example of leukocyte-mediated bone loss and inflammation that has pathogenic features similar to those observed in other inflammatory diseases such as arthritis." | 1.33 | RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis. ( Arita, M; Chiang, N; Ebrahimi, N; Hasturk, H; Kantarci, A; Levy, BD; Ohira, T; Petasis, NA; Serhan, CN; Van Dyke, TE, 2006) |
| "loss of attachment." | 1.33 | Studies on periodontitis and analyses of individuals at risk for periodontal diseases. ( Jansson, H, 2006) |
| "Moxifloxacin was effective, but a 100-fold MIC concentration was necessary to reduce P." | 1.32 | Efficacy of antibiotics against periodontopathogenic bacteria within epithelial cells: an in vitro study. ( Eick, S; Pfister, W, 2004) |
| "Continued disease progression characterised these patients who, nevertheless, mounted an immune response to the periodontal pathogens but this appeared to be inadequate to stop the disease." | 1.29 | Putative periodontal pathogens, antibody titres and avidities to them in a longitudinal study of patients with resistant periodontitis. ( Holbrook, WP; Kinane, DF; Kitsiou, N; Mooney, J; Sigurdsson, T, 1996) |
| "Metronidazole was effective against all isolates except for a few strains of B." | 1.28 | Identification, and susceptibility to seven antimicrobial agents, of 61 gram-negative anaerobic rods from periodontal pockets. ( Abu-Fanas, SH; Drucker, DB; Ganguli, LA; Hull, PS; Reeder, JC, 1991) |
| "Amoxicillin was found to be effective against all the strains tested." | 1.28 | Evaluation of the activity of four antimicrobial agents using an in vitro rapid micromethod against oral streptococci and various bacterial strains implicated in periodontitis. ( Chraïbi, DI; Girond, S; Michel, G, 1990) |
| "Metronidazole was significantly more effective than tetracycline or chlorhexidine on spirochaetes." | 1.27 | Comparison of the immediate effects on the sub-gingival microflora of acrylic strips containing 40% chlorhexidine, metronidazole or tetracycline. ( Addy, M; Langeroudi, M, 1984) |
| "Metronidazole was administered orally to four squirrel monkeys for 17 days at a daily dose of 100 mg/kg body weight." | 1.27 | Factors associated with occurrence and reversibility of connective tissue attachment loss. ( Polson, AM; Zappa, UE, 1988) |
| "Metronidazole was administered orally to four squirrel monkeys (100 mg/kg/bwt) for 17 days." | 1.27 | Effect of metronidazole on development of subgingival plaque and experimental periodontitis. ( Eisenberg, AD; Espeland, MA; Polson, AM; Zappa, UE, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 44 (13.21) | 18.7374 |
| 1990's | 106 (31.83) | 18.2507 |
| 2000's | 99 (29.73) | 29.6817 |
| 2010's | 54 (16.22) | 24.3611 |
| 2020's | 30 (9.01) | 2.80 |
| Authors | Studies |
|---|---|
| Dashper, S | 1 |
| Ang, CS | 1 |
| Liu, SW | 1 |
| Paolini, R | 1 |
| Veith, P | 1 |
| Reynolds, E | 1 |
| Ferreira, JA | 1 |
| Kantorski, KZ | 1 |
| Dubey, N | 1 |
| Daghrery, A | 1 |
| Fenno, JC | 1 |
| Mishina, Y | 1 |
| Chan, HL | 1 |
| Mendonça, G | 1 |
| Bottino, MC | 2 |
| Zou, P | 1 |
| Li, P | 1 |
| Liu, J | 1 |
| Cao, P | 1 |
| Luan, Q | 1 |
| Jain, P | 1 |
| Farooq, U | 1 |
| Nainwal, LM | 1 |
| Alam, M | 1 |
| Poonkuzhi, NP | 1 |
| Kuruniyan, MS | 1 |
| Mirza, MA | 1 |
| Iqbal, Z | 1 |
| Collins, JR | 1 |
| Ogando, G | 1 |
| González, R | 1 |
| Figuero, E | 1 |
| Marín, MJ | 1 |
| Sanz, M | 1 |
| Herrera, D | 2 |
| Steckiewicz, KP | 1 |
| Cieciórski, P | 1 |
| Barcińska, E | 1 |
| Jaśkiewicz, M | 1 |
| Narajczyk, M | 1 |
| Bauer, M | 1 |
| Kamysz, W | 1 |
| Megiel, E | 1 |
| Inkielewicz-Stepniak, I | 1 |
| Ramos, TCS | 1 |
| Boas, MLV | 1 |
| Nunes, CMM | 1 |
| Ferreira, CL | 1 |
| Pannuti, CM | 2 |
| Santamaria, MP | 1 |
| Jardini, MAN | 1 |
| Faveri, M | 5 |
| Retamal-Valdes, B | 5 |
| Mestnik, MJ | 2 |
| de Figueiredo, LC | 2 |
| Barão, VAR | 2 |
| Souza, JGS | 2 |
| Duarte, PM | 5 |
| Feres, M | 14 |
| Slots, J | 11 |
| da Silva, RVC | 1 |
| Rangel, TP | 1 |
| Corrêa, MG | 1 |
| de Freitas Monteiro, M | 1 |
| Casati, MZ | 1 |
| Ruiz, KG | 1 |
| Sallum, EA | 1 |
| Casarin, RCV | 1 |
| Sallum, AW | 1 |
| Liu, Y | 1 |
| Zhao, Y | 1 |
| Zhu, W | 1 |
| Han, M | 1 |
| Mi, F | 1 |
| Wang, B | 1 |
| Mugri, MH | 1 |
| Reise, M | 2 |
| Kranz, S | 1 |
| Guellmar, A | 1 |
| Wyrwa, R | 2 |
| Rosenbaum, T | 1 |
| Weisser, J | 1 |
| Jurke, A | 1 |
| Schnabelrauch, M | 2 |
| Heyder, M | 1 |
| Watts, DC | 2 |
| Sigusch, BW | 4 |
| Hagenfeld, D | 2 |
| Kleine Bardenhorst, S | 1 |
| Matern, J | 2 |
| Prior, K | 2 |
| Harks, I | 5 |
| Eickholz, P | 6 |
| Lorenz, K | 3 |
| Kim, TS | 6 |
| Kocher, T | 5 |
| Meyle, J | 5 |
| Kaner, D | 7 |
| Schlagenhauf, U | 6 |
| Harmsen, D | 4 |
| Ehmke, B | 9 |
| Koch, R | 3 |
| Göde, M | 1 |
| Nickles, K | 1 |
| Martins, R | 1 |
| Bertolini, M | 1 |
| Shibli, JA | 1 |
| van der Weijden, GA | 2 |
| Moonen, CG | 1 |
| Buurma, KG | 1 |
| Faruque, MR | 1 |
| Balta, MG | 1 |
| Liefferink, E | 1 |
| Bizzarro, S | 1 |
| Nicu, EA | 1 |
| Loos, BG | 1 |
| Gómez-Sandoval, JR | 1 |
| Robles-Cervantes, JA | 1 |
| Hernández-González, SO | 1 |
| Espinel-Bermudez, MC | 1 |
| Mariaud-Schmidt, R | 1 |
| Martínez-Rodríguez, V | 1 |
| Morgado-Castillo, KC | 1 |
| Mercado-Sesma, AR | 1 |
| Teughels, W | 1 |
| Oud, V | 1 |
| Martín, C | 1 |
| Matesanz, P | 1 |
| Souza, EQM | 1 |
| da Rocha, TE | 1 |
| Toro, LF | 1 |
| Guiati, IZ | 1 |
| Ervolino, E | 1 |
| Garcia, VG | 1 |
| Wainwright, M | 1 |
| Theodoro, LH | 1 |
| Mensi, M | 1 |
| Calza, S | 1 |
| Sordillo, A | 1 |
| Scotti, E | 1 |
| Garzetti, G | 1 |
| Ardila, CM | 1 |
| Hernández-Casas, C | 1 |
| Bedoya-García, JA | 1 |
| Liang, G | 1 |
| Shi, H | 1 |
| Qi, Y | 1 |
| Li, J | 1 |
| Jing, A | 1 |
| Liu, Q | 1 |
| Feng, W | 1 |
| Li, G | 2 |
| Gao, S | 1 |
| Fermiano, D | 1 |
| Figueiredo, LC | 4 |
| Mayer, MPA | 1 |
| Lee, JJ | 1 |
| Bittinger, K | 1 |
| Teles, F | 1 |
| Cruz, DFD | 1 |
| da Silva, HDP | 1 |
| Miranda, TS | 3 |
| Cosgarea, R | 2 |
| Eick, S | 2 |
| Jepsen, S | 2 |
| Arweiler, NB | 3 |
| Juncar, R | 2 |
| Tristiu, R | 2 |
| Salvi, GE | 3 |
| Heumann, C | 2 |
| Sculean, A | 2 |
| Wang, MJ | 1 |
| DA, Y | 1 |
| Zheng, LC | 1 |
| Zhao, H | 1 |
| Hu, J | 1 |
| Zhao, L | 1 |
| Lu, H | 1 |
| He, L | 1 |
| Jin, D | 1 |
| Zhu, Y | 1 |
| Meng, H | 1 |
| Gad, HA | 3 |
| Kamel, AO | 1 |
| Ezzat, OM | 1 |
| El Dessouky, HF | 1 |
| Sammour, OA | 1 |
| Lascu, L | 1 |
| Lin, JH | 1 |
| Feng, F | 1 |
| Yu, MC | 1 |
| Wang, CH | 1 |
| Chang, PC | 1 |
| Preus, HR | 5 |
| Gjermo, P | 4 |
| Baelum, V | 5 |
| McGowan, K | 1 |
| McGowan, T | 1 |
| Ivanovski, S | 1 |
| Mombelli, A | 12 |
| Fritoli, A | 1 |
| Faustino, E | 1 |
| Souto, MLS | 1 |
| de Franco Rodrigues, M | 1 |
| Giudicissi, M | 1 |
| Nogueira, BCL | 1 |
| Saraiva, L | 1 |
| Romito, GA | 1 |
| Yassine, LLS | 1 |
| Soares, GMS | 1 |
| Razzaq, S | 1 |
| Hanif, S | 1 |
| Syed, MA | 1 |
| Iqbal, J | 1 |
| Hassan, SS | 1 |
| Raza, SA | 1 |
| Riaz, H | 1 |
| Abid, F | 1 |
| Hoffmann, T | 2 |
| Rajendran, M | 1 |
| Looney, S | 1 |
| Singh, N | 1 |
| Elashiry, M | 1 |
| Meghil, MM | 1 |
| El-Awady, AR | 1 |
| Tawfik, O | 1 |
| Susin, C | 1 |
| Arce, RM | 1 |
| Cutler, CW | 1 |
| Lübcke, PM | 1 |
| Ebbers, MNB | 1 |
| Volzke, J | 1 |
| Bull, J | 1 |
| Kneitz, S | 1 |
| Engelmann, R | 1 |
| Lang, H | 1 |
| Kreikemeyer, B | 1 |
| Müller-Hilke, B | 1 |
| Polonyi, M | 1 |
| Prenninger, N | 1 |
| Haririan, H | 1 |
| Winklehner, P | 1 |
| Kierstein, S | 1 |
| Pichayakorn, W | 1 |
| Boonme, P | 1 |
| Wayakanon, K | 1 |
| Thornhill, MH | 1 |
| Douglas, CW | 1 |
| Lewis, AL | 1 |
| Warren, NJ | 1 |
| Pinnock, A | 1 |
| Armes, SP | 1 |
| Battaglia, G | 1 |
| Murdoch, C | 1 |
| Sundararaj, SC | 1 |
| Thomas, MV | 1 |
| Peyyala, R | 1 |
| Dziubla, TD | 1 |
| Puleo, DA | 1 |
| Dev, YP | 1 |
| Goyal, OP | 1 |
| Graziano, TS | 1 |
| Closs, P | 1 |
| Poppi, T | 1 |
| Franco, GC | 1 |
| Cortelli, JR | 1 |
| Groppo, FC | 1 |
| Cogo, K | 1 |
| Almaghlouth, AA | 1 |
| Cionca, N | 5 |
| Cancela, JA | 1 |
| Décaillet, F | 2 |
| Courvoisier, DS | 3 |
| Giannopoulou, C | 6 |
| Sandvik, L | 2 |
| Arthur, RA | 1 |
| Waeiss, RA | 1 |
| Kamocki, K | 1 |
| Gregson, KS | 1 |
| Gregory, RL | 1 |
| Kulik Kunz, EM | 1 |
| Lenkeit, K | 1 |
| Waltimo, T | 2 |
| Weiger, R | 2 |
| Walter, C | 2 |
| Tanwir, F | 1 |
| Marrone, G | 1 |
| Tariq, A | 1 |
| Lundborg, CS | 1 |
| Almaghlouth, A | 4 |
| Dziedzic, A | 1 |
| Wojtyczka, RD | 1 |
| Yang, Z | 1 |
| da Silva, MA | 1 |
| Oliveira, RN | 1 |
| Mendonça, RH | 1 |
| Lourenço, TG | 1 |
| Colombo, AP | 2 |
| Tanaka, MN | 1 |
| Tude, EM | 1 |
| da Costa, MF | 1 |
| Thiré, RM | 1 |
| Do, MP | 1 |
| Neut, C | 1 |
| Metz, H | 1 |
| Delcourt, E | 1 |
| Mäder, K | 1 |
| Siepmann, J | 1 |
| Siepmann, F | 1 |
| Neering, SH | 1 |
| Adyani-Fard, S | 1 |
| Klocke, A | 1 |
| Rüttermann, S | 1 |
| Flemmig, TF | 6 |
| Beikler, T | 5 |
| Marty, M | 1 |
| Bonner, M | 1 |
| Vaysse, F | 1 |
| Oya, M | 1 |
| Tanimoto, T | 1 |
| Yamamoto, T | 1 |
| Hakozaki, Y | 1 |
| Doering, S | 1 |
| Holtfreter, B | 1 |
| Gravemeier, M | 1 |
| Cherkaoui, A | 1 |
| Schrenzel, J | 1 |
| Khan, G | 1 |
| Yadav, SK | 1 |
| Patel, RR | 1 |
| Nath, G | 1 |
| Bansal, M | 1 |
| Mishra, B | 1 |
| Zandbergen, D | 1 |
| Slot, DE | 1 |
| Niederman, R | 1 |
| Van der Weijden, FA | 1 |
| Tamashiro, NS | 1 |
| Maciel, SS | 1 |
| Ré, AC | 1 |
| Ferreira, MP | 1 |
| Freitas, O | 1 |
| Aires, CP | 1 |
| Akincibay, H | 1 |
| Orsal, SO | 1 |
| Sengün, D | 1 |
| Tözüm, TF | 1 |
| El-Nabarawi, MA | 2 |
| Abd El-Hady, SS | 2 |
| Milánkovits, M | 1 |
| Motamedi, MH | 1 |
| Lotfi, A | 1 |
| Azizi, T | 1 |
| Moshref, M | 1 |
| Valenza, G | 1 |
| Veihelmann, S | 1 |
| Peplies, J | 1 |
| Tichy, D | 1 |
| Roldan-Pareja, Mdel C | 1 |
| Vogel, U | 1 |
| Aleksandrov, MT | 1 |
| Prikuls, VF | 1 |
| Bogdanov, VIu | 1 |
| Vasil'ev, EN | 1 |
| Boches, SK | 1 |
| Cotton, SL | 1 |
| Goodson, JM | 2 |
| Kent, R | 1 |
| Haffajee, AD | 9 |
| Socransky, SS | 10 |
| Hasturk, H | 2 |
| Van Dyke, TE | 4 |
| Dewhirst, F | 1 |
| Paster, BJ | 1 |
| van Winkelhoff, AJ | 18 |
| Winkel, EG | 8 |
| Fu, XY | 1 |
| Li, GF | 1 |
| Rizzo, A | 1 |
| Paolillo, R | 1 |
| Guida, L | 1 |
| Annunziata, M | 1 |
| Bevilacqua, N | 1 |
| Tufano, MA | 1 |
| Phiri, R | 1 |
| Feller, L | 3 |
| Blignaut, E | 2 |
| Kulik, EM | 1 |
| Zitzmann, NU | 1 |
| Mouratidou, A | 1 |
| Karbach, J | 1 |
| d'Hoedt, B | 1 |
| Al-Nawas, B | 1 |
| López, NJ | 4 |
| Quintero, A | 1 |
| Casanova, PA | 1 |
| Ibieta, CI | 1 |
| López, R | 1 |
| Müller, U | 1 |
| Zylinski, M | 1 |
| Völpel, A | 1 |
| Berg, A | 1 |
| Jandt, KD | 1 |
| Dabhi, MR | 1 |
| Sheth, NR | 1 |
| Senhorinho, GN | 1 |
| Nakano, V | 1 |
| Liu, C | 1 |
| Song, Y | 1 |
| Finegold, SM | 1 |
| Avila-Campos, MJ | 3 |
| Amid, R | 1 |
| Tabeie, MB | 1 |
| Kadkhodazadeh, M | 1 |
| Mehdizadeh, AR | 1 |
| Youssefi, N | 1 |
| Rams, TE | 4 |
| Feik, D | 4 |
| Mortensen, JE | 1 |
| Degener, JE | 1 |
| Gunleiksrud, TM | 1 |
| Mayfield, L | 1 |
| Rutar, A | 2 |
| Suvan, J | 2 |
| Garrett, S | 1 |
| Lang, NP | 5 |
| Grudianov, AI | 3 |
| Ovchinnikova, VV | 3 |
| Serebriakova, LE | 1 |
| Allard, K | 2 |
| Som, S | 2 |
| Schmid, B | 1 |
| Walker, C | 3 |
| Karpinia, K | 1 |
| Tang, Z | 1 |
| Cao, C | 1 |
| Sha, Y | 1 |
| Lin, Y | 1 |
| Wang, X | 2 |
| Yang, H | 1 |
| Xu, Y | 1 |
| Zhang, J | 1 |
| Wang, H | 1 |
| Luo, J | 1 |
| Su, W | 1 |
| He, Q | 1 |
| Huang, X | 1 |
| Buchmann, R | 2 |
| Müller, RF | 3 |
| Lange, DE | 4 |
| Buduneli, E | 1 |
| Tünger, A | 1 |
| Evrenosoglu, E | 1 |
| Bilgiç, A | 1 |
| Al-Mubarak, SA | 1 |
| Karring, T | 4 |
| Ho, A | 1 |
| Mishkin, DJ | 1 |
| Jeffcoat, MK | 1 |
| Hauth, JC | 1 |
| Geurs, NC | 1 |
| Reddy, MS | 1 |
| Cliver, SP | 1 |
| Hodgkins, PM | 1 |
| Goldenberg, RL | 1 |
| Grenier, D | 1 |
| Roy, E | 1 |
| Mayrand, D | 1 |
| Hanes, PJ | 1 |
| Purvis, JP | 1 |
| Gunsolley, JC | 1 |
| Samaranayake, LP | 1 |
| Perinetti, G | 1 |
| Paolantonio, M | 1 |
| Cordella, C | 1 |
| D'Ercole, S | 1 |
| Serra, E | 1 |
| Piccolomini, R | 1 |
| Bonito, AJ | 2 |
| Lohr, KN | 2 |
| Lux, L | 2 |
| Sutton, S | 1 |
| Jackman, A | 1 |
| Whitener, L | 1 |
| Evensen, C | 1 |
| Shangase, L | 1 |
| Riep, B | 2 |
| Flemmig, T | 1 |
| Göbel, U | 1 |
| Moter, A | 2 |
| Pavia, M | 1 |
| Nobile, CG | 1 |
| Bianco, A | 1 |
| Angelillo, IF | 1 |
| Handal, T | 1 |
| Olsen, I | 1 |
| Walker, CB | 1 |
| Caugant, DA | 1 |
| Sun, Y | 1 |
| Wu, YF | 1 |
| Xiao, XR | 1 |
| Ding, Y | 1 |
| Zhu, Z | 1 |
| Lundgren, T | 1 |
| Renvert, S | 1 |
| Carvalho, LH | 3 |
| D'Avila, GB | 3 |
| Leão, A | 3 |
| Pfister, W | 3 |
| Abbas, F | 4 |
| Poulet, PP | 3 |
| Duffaut, D | 3 |
| Barthet, P | 1 |
| Brumpt, I | 1 |
| Jorgensen, MG | 1 |
| Aalam, A | 1 |
| Brochut, P | 2 |
| Plagnat, D | 2 |
| Casagni, F | 1 |
| Pfitzner, A | 2 |
| Nietzsch, T | 1 |
| Glockmann, E | 4 |
| Gonçalves, C | 1 |
| Milian, E | 3 |
| Güntsch, A | 1 |
| Queiroz, AC | 1 |
| Santos, JD | 1 |
| Monteiro, FJ | 1 |
| Rumiantsev, VA | 1 |
| Iusufov, MV | 1 |
| Khiutti, NV | 1 |
| Moskaleva, IV | 1 |
| Slobodina, EV | 1 |
| Guerrero, A | 2 |
| Griffiths, GS | 2 |
| Nibali, L | 1 |
| Moles, DR | 3 |
| Laurell, L | 1 |
| Tonetti, MS | 2 |
| Kone, D | 2 |
| Kamagate, A | 2 |
| Feres-Filho, EJ | 2 |
| Ahuja, V | 1 |
| Shin, RH | 1 |
| Mudgil, A | 1 |
| Nanda, V | 1 |
| Schoor, R | 1 |
| Kantarci, A | 1 |
| Ohira, T | 1 |
| Arita, M | 1 |
| Ebrahimi, N | 1 |
| Chiang, N | 1 |
| Petasis, NA | 1 |
| Levy, BD | 1 |
| Serhan, CN | 1 |
| Xajigeorgiou, C | 1 |
| Sakellari, D | 1 |
| Slini, T | 1 |
| Baka, A | 1 |
| Konstantinidis, A | 1 |
| Gaggl, AJ | 1 |
| Rainer, H | 1 |
| Grund, E | 1 |
| Chiari, FM | 1 |
| Andersen, E | 1 |
| Akncbay, H | 1 |
| Senel, S | 1 |
| Ay, ZY | 1 |
| Jansson, H | 1 |
| Da Silva, I | 1 |
| Japlit, MR | 1 |
| Schwarz, F | 1 |
| Herten, M | 1 |
| Sager, M | 1 |
| Rothamel, D | 1 |
| Becker, J | 1 |
| Zee, KY | 1 |
| Lee, DH | 1 |
| Corbet, EF | 1 |
| Dmitrieva, NA | 2 |
| Torresyap, G | 1 |
| Pahkla, ER | 1 |
| Koppel, T | 1 |
| Naaber, P | 1 |
| Saag, M | 1 |
| Loivukene, K | 1 |
| Christan, C | 1 |
| Dietrich, T | 1 |
| Bernimoulin, JP | 4 |
| Kleber, BM | 2 |
| Friedmann, A | 2 |
| Moeintaghavi, A | 1 |
| Talebi-ardakani, MR | 1 |
| Haerian-ardakani, A | 1 |
| Zandi, H | 1 |
| Taghipour, S | 1 |
| Fallahzadeh, H | 1 |
| Pakzad, A | 1 |
| Fahami, N | 1 |
| Leiknes, T | 1 |
| Leknes, KN | 1 |
| Böe, OE | 2 |
| Skavland, RJ | 1 |
| Lie, T | 3 |
| Dannewitz, B | 1 |
| Pohl, S | 2 |
| Horz, HP | 1 |
| Conrads, G | 1 |
| Echeverría, JJ | 1 |
| Moreira, RM | 1 |
| Tomás, I | 1 |
| Tomás, M | 1 |
| Alvarez, M | 1 |
| Velasco, D | 1 |
| Potel, C | 1 |
| Limeres, J | 1 |
| Diz, P | 1 |
| Sedlacek, MJ | 1 |
| Hopfenmüller, W | 2 |
| Hussein, I | 1 |
| Ranka, M | 1 |
| Gilbert, A | 1 |
| Davey, K | 1 |
| Barat, R | 1 |
| Srinatha, A | 1 |
| Pandit, JK | 1 |
| Anupurba, S | 1 |
| Mittal, N | 1 |
| Patel, M | 1 |
| Lemmer, J | 1 |
| Hofstetter, HW | 1 |
| Mitchell, DA | 1 |
| Loesche, WJ | 10 |
| Syed, SA | 3 |
| Morrison, EC | 3 |
| Kerry, GA | 1 |
| Higgins, T | 1 |
| Stoll, J | 2 |
| Addy, M | 7 |
| Alam, L | 1 |
| Rawle, L | 1 |
| Nuki, K | 2 |
| Soskolne, WA | 2 |
| Raisz, LG | 1 |
| Kornman, KS | 2 |
| Alander, C | 1 |
| Siegrist, B | 1 |
| Yeung, FI | 2 |
| Newman, HN | 6 |
| Wan Yusof, WZ | 2 |
| Strahan, JD | 1 |
| Coventry, JF | 1 |
| Lundström, A | 1 |
| Johansson, LA | 2 |
| Hamp, SE | 1 |
| Friskin, KW | 1 |
| Langeroudi, M | 2 |
| Quee, TC | 2 |
| Roussou, T | 1 |
| Chan, EC | 2 |
| Laughon, B | 1 |
| Grossman, NS | 1 |
| Flynn, MJ | 2 |
| Dowell, P | 1 |
| al-Arrayed, F | 1 |
| Adam, S | 1 |
| Moran, J | 2 |
| Pavicić, MJ | 5 |
| Pavivić-Temming, YA | 1 |
| de Graaff, J | 8 |
| Stoltze, K | 4 |
| Rotzetter, PA | 1 |
| Le Liboux, A | 1 |
| Pichard, E | 1 |
| Cimasoni, G | 1 |
| Kamel, E | 1 |
| Legrand, R | 1 |
| el Azzouni, MZ | 1 |
| el Badry, AM | 1 |
| Seymour, RA | 2 |
| Heasman, PA | 1 |
| Sbordone, L | 2 |
| Barone, A | 2 |
| Ramaglia, L | 2 |
| Ciaglia, RN | 2 |
| Iacono, VJ | 1 |
| Cunniffe, JG | 1 |
| Giordano, JR | 2 |
| Khatiblou, FA | 1 |
| Douqué, NH | 1 |
| Steures, RW | 1 |
| Hitzig, C | 4 |
| Charbit, Y | 4 |
| Bitton, C | 2 |
| Fosse, T | 2 |
| Teboul, M | 2 |
| Hannoun, L | 2 |
| Varonne, R | 1 |
| Greenstein, G | 4 |
| Grossman, N | 1 |
| Giordano, J | 2 |
| Overbeek, BP | 1 |
| van den Bergh, JP | 1 |
| Ernst, JP | 1 |
| Listgarten, MA | 3 |
| Lai, CH | 1 |
| Young, V | 1 |
| von Troil-Lindén, B | 3 |
| Torkko, H | 3 |
| Alaluusua, S | 3 |
| Jousimies-Somer, H | 4 |
| Asikainen, S | 5 |
| Walsh, TF | 1 |
| Carvalho, MA | 1 |
| Zelante, F | 1 |
| Needleman, IG | 4 |
| Pandya, NV | 2 |
| Smith, SR | 2 |
| Foyle, DM | 2 |
| Stelzel, M | 2 |
| Florès-de-Jacoby, L | 2 |
| Romanov, AE | 1 |
| Tsarev, VN | 1 |
| Rudneva, EV | 1 |
| Nieminen, A | 1 |
| Kari, K | 1 |
| Uitto, VJ | 1 |
| Saxén, L | 1 |
| Mättö, J | 1 |
| Saarela, M | 1 |
| Könönen, E | 1 |
| Kleinfelder, JW | 2 |
| Topoll, HH | 1 |
| Böcker, W | 1 |
| Bollen, CM | 1 |
| Quirynen, M | 1 |
| Holbrook, WP | 1 |
| Mooney, J | 1 |
| Sigurdsson, T | 1 |
| Kitsiou, N | 1 |
| Kinane, DF | 1 |
| Noyan, U | 2 |
| Yilmaz, S | 2 |
| Kuru, B | 2 |
| Kadir, T | 2 |
| Acar, O | 2 |
| Büget, E | 2 |
| Ericsson, I | 1 |
| Persson, LG | 3 |
| Berglundh, T | 4 |
| Edlund, T | 1 |
| Lindhe, J | 5 |
| Timmerman, MF | 2 |
| Vangsted, T | 2 |
| Van der Velden, U | 2 |
| Ciancio, S | 1 |
| Elter, JR | 1 |
| Lawrence, HP | 1 |
| Offenbacher, S | 1 |
| Beck, JD | 1 |
| Wolf, J | 1 |
| Torppa, J | 1 |
| Kopp, C | 2 |
| Karch, H | 4 |
| Klaiber, B | 4 |
| Müller, HP | 1 |
| Heinecke, A | 1 |
| Borneff, M | 1 |
| Kiencke, C | 1 |
| Knopf, A | 1 |
| Loesche, W | 1 |
| Wang, R | 1 |
| Chen, L | 1 |
| Ni, K | 1 |
| Killoy, WJ | 2 |
| Polson, AM | 4 |
| Awartani, FA | 1 |
| Zulqarnain, BJ | 1 |
| Polson, A | 1 |
| Krok, L | 1 |
| Liljenberg, B | 1 |
| Westfelt, E | 1 |
| Serino, G | 2 |
| Palmer, RM | 2 |
| Matthews, JP | 2 |
| Wilson, RF | 2 |
| Bruun, G | 1 |
| Rudhart, A | 1 |
| Purucker, P | 2 |
| Kage, A | 1 |
| Magnusson, I | 2 |
| Borysenko, AV | 1 |
| Nesin, OF | 1 |
| Piechkovs'kyĭ, KIe | 1 |
| Rakhniĭ, ZhI | 1 |
| Gamonal, JA | 2 |
| Worch, KP | 1 |
| Wetzel, AC | 1 |
| Vlassis, J | 1 |
| Caffesse, RG | 1 |
| Hämmerle, CH | 1 |
| Lodter, JP | 2 |
| Söder, B | 2 |
| Nedlich, U | 2 |
| Jin, LJ | 1 |
| Madinier, IM | 1 |
| Fosse, TB | 1 |
| Hannoun, LR | 1 |
| Eksteen, H | 1 |
| Danesh-Meyer, MJ | 1 |
| Schmidt, H | 1 |
| Araújo, MG | 1 |
| Gröndahl, K | 1 |
| Vandenbroucke-Grauls, CM | 1 |
| Martinez, B | 1 |
| Tonetti, M | 1 |
| Collins, AM | 2 |
| Okamoto, AC | 1 |
| Gaetti-Jardim, E | 1 |
| Cai, S | 1 |
| Sigusch, B | 2 |
| Klinger, G | 2 |
| Smart, GJ | 1 |
| Bulman, JS | 1 |
| Weiss, G | 1 |
| Shrowder, J | 1 |
| Beier, M | 1 |
| Rosling, B | 1 |
| Ramberg, P | 1 |
| Hellström, MK | 1 |
| Mellado, JR | 1 |
| Freedman, AL | 1 |
| Salkin, LM | 1 |
| Stein, MD | 1 |
| Schneider, DB | 1 |
| Cutler, RH | 1 |
| Beertsen, W | 1 |
| Piscaer, M | 1 |
| Everts, V | 1 |
| Sennerby, L | 1 |
| Coulibaly, NT | 1 |
| Brou, E | 1 |
| Sixou, M | 1 |
| Mikx, FH | 2 |
| König, KG | 1 |
| van Rossum, GM | 1 |
| Bruers, JJ | 1 |
| Pacheco, JJ | 1 |
| Coelho, C | 1 |
| Salazar, F | 1 |
| Contreras, A | 1 |
| Velazco, CH | 1 |
| Groselj, D | 2 |
| Grabec, I | 1 |
| Nunn, ME | 1 |
| Ferenczy, I | 1 |
| Nyárasdy, I | 1 |
| Békésy, Z | 1 |
| Jones, JH | 1 |
| Bianco, R | 1 |
| Tijhof, CJ | 1 |
| Nachnani, S | 1 |
| Scuteri, A | 1 |
| Newman, MG | 1 |
| Avanessian, AB | 1 |
| Lomeli, SL | 1 |
| Pedrazzoli, V | 1 |
| Kilian, M | 1 |
| Teng, YT | 1 |
| Sodek, J | 1 |
| McCulloch, CA | 2 |
| Stellfeld, M | 1 |
| Klinge, B | 2 |
| Kuvatanasuhati, J | 1 |
| Attström, R | 2 |
| Kalfas, S | 1 |
| Edwardsson, S | 1 |
| Kisch, J | 2 |
| Lewin, B | 1 |
| Ainamo, J | 1 |
| Ellingsen, BH | 1 |
| Hansen, BF | 1 |
| Paunio, K | 1 |
| Aitken, S | 1 |
| Birek, P | 1 |
| Kulkarni, GV | 1 |
| Lee, WL | 1 |
| Huynh, C | 1 |
| Roch-Arveiller, M | 1 |
| Meyer, J | 1 |
| Giroud, JP | 1 |
| Hujoel, P | 1 |
| Schwarcz, J | 1 |
| Smith, BA | 3 |
| Wade, WG | 2 |
| Morgan, JR | 1 |
| Newcombe, R | 1 |
| Zappa, UE | 3 |
| Espeland, MA | 2 |
| Baldan, N | 1 |
| Freeman, E | 1 |
| Abu-Fanas, SH | 1 |
| Drucker, DB | 1 |
| Hull, PS | 1 |
| Reeder, JC | 1 |
| Ganguli, LA | 1 |
| Schmidt, E | 2 |
| Caffesse, R | 1 |
| Hujoel, PP | 2 |
| Linden, GJ | 1 |
| Lin, JM | 1 |
| Peng, FY | 1 |
| Lin, SC | 1 |
| Chraïbi, DI | 1 |
| Girond, S | 1 |
| Michel, G | 1 |
| Goené, RJ | 2 |
| Rodenburg, JP | 2 |
| Söder, PO | 1 |
| Frithiof, L | 1 |
| Wikner, S | 1 |
| Wouters, F | 1 |
| Engström, PE | 1 |
| Rubin, B | 1 |
| Winkler, JR | 1 |
| Murray, PA | 1 |
| Grassi, M | 1 |
| Hammerle, C | 1 |
| Deasy, PB | 1 |
| Collins, AE | 1 |
| MacCarthy, DJ | 1 |
| Russell, RJ | 1 |
| De Mars, G | 1 |
| Lazzaro, AJ | 1 |
| Bissada, NF | 1 |
| Jenkins, WM | 1 |
| MacFarlane, TW | 1 |
| Gilmour, WH | 1 |
| Ramsay, I | 1 |
| MacKenzie, D | 1 |
| Lapougeas, JC | 1 |
| Bitton-Sebag, C | 1 |
| Gäbler, K | 1 |
| Caffessee, R | 1 |
| Gusberti, FA | 1 |
| Schmidt, EF | 1 |
| Webber, RL | 1 |
| Ruttimann, UE | 1 |
| Fan, MW | 1 |
| Suomala, P | 1 |
| Summanen, P | 1 |
| Cop, L | 1 |
| Korbar-Smid, J | 1 |
| Kristl, J | 1 |
| van Oosten, MA | 1 |
| Renggli, HH | 1 |
| Clark, C | 1 |
| Lautar-Lemay, C | 1 |
| Bergeron, MJ | 1 |
| Bourgouin, J | 1 |
| Stamm, J | 1 |
| Eisenberg, AD | 1 |
| Mahmood, MM | 1 |
| Dolby, AE | 1 |
| Walsh, MM | 1 |
| Buchanan, SA | 1 |
| Hoover, CI | 1 |
| Newbrun, E | 1 |
| Taggart, EJ | 1 |
| Armitage, GC | 1 |
| Robertson, PB | 1 |
| Aziz-Gandour, IA | 1 |
| Watts, T | 1 |
| Palmer, R | 1 |
| Floyd, P | 1 |
| Joyston-Bechal, S | 1 |
| Smales, FC | 1 |
| Duckworth, R | 1 |
| Hassan, H | 1 |
| Higgins, TJ | 1 |
| Hunter, N | 1 |
| Knox, KW | 1 |
| Giedrys-Leeper, E | 1 |
| Selipsky, H | 1 |
| Williams, BL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Adjunctive Use of Antimicrobial Photodynamic Therapy, Light-emitting-diode Photobiomodulation, and Ozone Therapy in Regenerative Treatment of Stage III Grade C Periodontitis[NCT05447026] | 48 participants (Actual) | Interventional | 2018-01-01 | Completed | |||
| Clinical and Microbiological Effects of Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis: 1-year Randomized Double-blinded Controlled Clinical Trial[NCT05444218] | 94 participants (Anticipated) | Interventional | 2021-05-01 | Recruiting | |||
| Timing of Administration of Systemic Antibiotics Associated With Scaling and Root Planing in the Treatment of Periodontitis: Clinical and Microbiological Evaluation[NCT06177119] | 72 participants (Actual) | Interventional | 2012-01-31 | Active, not recruiting | |||
| The Treatment of Periodontal Diseases. A Randomized, Blinded, Five Years Follow-up, Four-arm, Placebo Controlled Clinical Intervention Trial[NCT01318928] | Phase 4 | 184 participants (Actual) | Interventional | 2008-01-31 | Active, not recruiting | ||
| Influence of Moment of Systemic Metronidazole and Amoxicillin Administration in the Treatment of Chronic Periodontitis: a Randomized Clinical Trial.[NCT02954393] | 180 participants (Anticipated) | Interventional | 2015-05-31 | Active, not recruiting | |||
| Adjunctive Antimicrobial Therapy of Periodontitis: Long-Term Effects on Disease Progression and Oral Microbiological Colonization[NCT00707369] | Phase 4 | 540 participants (Actual) | Interventional | 2008-10-31 | Completed | ||
| Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing on Clinical, Microbiological and Systemic Response[NCT02197260] | Phase 4 | 80 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial[NCT02735395] | Phase 4 | 110 participants (Actual) | Interventional | 2011-07-31 | Active, not recruiting | ||
| Lepidium Sativum Extract Versus Simvastatin as an Adjunctive Local Delivery Agents to Non-Surgical Periodontal Therapy: A Randomized Controlled Clinical Trial With Biochemical Analysis[NCT05657015] | Phase 4 | 30 participants (Actual) | Interventional | 2021-09-01 | Completed | ||
| Metronidazole and Amoxicillin as Adjuncts to Scaling and Root Planing for the Treatment of Type 2 Diabetic Subjects With Periodontitis: a Randomized Placebo-controlled Clinical Trial[NCT02135952] | Phase 4 | 58 participants (Actual) | Interventional | 2011-09-30 | Active, not recruiting | ||
| Impact of Periodontal Therapy on Patients With Diabetes: A Pilot Study[NCT04830969] | Phase 2 | 116 participants (Actual) | Interventional | 2016-11-08 | Completed | ||
| Effectiveness of Metronidazole Gel and Mobile Telephone Short- Message Service Reminders on Gingivitis in Orthodontic Patients: A Randomized Controlled Trial[NCT03508999] | Phase 4 | 63 participants (Actual) | Interventional | 2018-05-23 | Completed | ||
| EFFECT OF LOCALLY DELIVERED ALOE VERA GEL AS AN ADJUNCT TO SCALING AND ROOT PLANING IN THE TREATMENT OF CHRONIC PERIODONTITIS: A SPLIT-MOUTH CLINICAL AND MICROBIOLOGICAL STUDY[NCT02462993] | Phase 2/Phase 3 | 12 participants (Actual) | Interventional | 2014-02-28 | Completed | ||
| Full-mouth Periodontal Debridement With or Without Adjunctive Metronidazole Gel in Smoking Patients With Chronic Periodontitis[NCT01938183] | Phase 2 | 30 participants (Actual) | Interventional | 2006-11-30 | Completed | ||
| Vital Root-resective Therapy in Furcation-involved Maxillary Molars[NCT05259982] | 10 participants (Anticipated) | Interventional | 2022-03-04 | Active, not recruiting | |||
| Short & Medium Term Outcomes of Periodontal Regenerative Procedures. A Two-part Study With a) Analysis of Periodontal Records of a Cohort of Periodontitis Patients and b) a Single Visit Recall and Comprehensive Periodontal Re-evaluation[NCT04971174] | 200 participants (Anticipated) | Observational | 2022-09-30 | Enrolling by invitation | |||
| Clinical Effects of Doxycycline in the Treatment of Aggressive Periodontitis: Comparative Clinical Study[NCT03727620] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2014-01-06 | Completed | ||
| Clinical Evaluation of Systemic Moxifloxacin Compared to Amoxicillin Plus Metronidazole Adjunct to Non-surgical Treatment in Generalized Aggressive Periodontitis: A Randomized Clinical Trial[NCT02223702] | Phase 4 | 39 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| The Effect of Periimplantitis Surgical Regenerative Therapy Using Bovine Bone Substitute With Hyaluronic Acid: Randomized Controlled Clinical Trials[NCT05171582] | 25 participants (Actual) | Interventional | 2021-04-15 | Active, not recruiting | |||
| The Effect of Preoperative Antibiotics on Peri-implant Crestal Bone Remodelling and Postoperative Pain: A Randomized Controlled Trial[NCT04280406] | Phase 1 | 50 participants (Anticipated) | Interventional | 2020-02-25 | Recruiting | ||
| Surgical Treatment of Peri-implantitis With and Without Adjunctive Use of Antibiotics : a Controlled and Randomized Clinical Study[NCT01857804] | Phase 4 | 100 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Analysis of microbiome community changes using the healthy plane (HP) as a reference. A healthy plane was calculated by fitting a plane that minimizes the sum of squares of distances from HC samples to the nearest point on the plane. The distance of each sample to the HP was then calculated. Higher values of distance to HP mean microbiome community changes towards disease status (NCT04830969)
Timeframe: Baseline to 6 Months
| Intervention | distance to the healthy plane (Mean) |
|---|---|
| Group A: SRP + SPT | -2.16 |
| Group B: SRP | -1.26 |
The high-sensitivity C-reactive protein (hs-CRP) blood test measures body inflammation indicating infection or a chronic inflammatory disease such as periodontitis or diabetes. It also can be used to evaluate risk of developing coronary artery disease. A normal reading is less than 10 milligram per liter (mg/L); a level greater than 10 mg/L is a sign of serious infection, trauma or chronic disease likely requiring further testing to determine cause (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mg/L (Mean) |
|---|---|
| Group A: SRP + SPT | -0.33 |
| Group B: SRP | -1.25 |
The high-sensitivity C-reactive protein (hs-CRP) blood test measures body inflammation indicating infection or a chronic inflammatory disease such as periodontitis or diabetes. It also can be used to evaluate risk of developing coronary artery disease. A normal reading is less than 10 milligram per liter (mg/L); a level greater than 10 mg/L is a sign of serious infection, trauma or chronic disease likely requiring further testing to determine cause (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mg/L (Mean) |
|---|---|
| Diabetic + SRP + SPT | 0.23 |
| Diabetic + SRP | -2.23 |
| Non-Diabetic + SRP + SPT | -0.41 |
| Non-Diabetic + SRP | 0.01 |
Periodontal PD in millimeters is measured with a UNC-15 periodontal probe on 6 sites per tooth; site status is compared between timepoints measured (NCT04830969)
Timeframe: Baseline to 3 months
| Intervention | mm (Mean) |
|---|---|
| Group A: SRP + SPT | -0.31 |
| Group B: SRP | -0.21 |
Periodontal PD in millimeters is measured with a UNC-15 periodontal probe on 6 sites per tooth; site status is compared between timepoints measured (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mm (Mean) |
|---|---|
| Group A: SRP + SPT | -0.25 |
| Group B: SRP | -0.18 |
Fasting blood sugar/glucose (FBS/FBG) is tested with a blood sample taken after an overnight fast. A fasting blood sugar level less than 100 mg/dL is normal; a fasting blood sugar level from 100 to 125 mg/dL is considered prediabetes; a level 126 mg/dL (7 mmol/L) or higher on two separate tests, indicates diabetes. (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mg/dL (Mean) |
|---|---|
| Group A: SRP + SPT | -2.13 |
| Group B: SRP | 1.85 |
Fasting blood sugar/glucose (FBS/FBG) is tested with a blood sample taken after an overnight fast. A fasting blood sugar level less than 100 mg/dL is normal; a fasting blood sugar level from 100 to 125 mg/dL is considered prediabetes; a level 126 mg/dL (7 mmol/L) or higher on two separate tests, indicates diabetes. (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | mg/dL (Mean) |
|---|---|
| Diabetic + SRP + SPT | -5.05 |
| Diabetic + SRP | 2.74 |
| Non-Diabetic + SRP + SPT | 0.42 |
| Non-Diabetic + SRP | 0.72 |
Hemoglobin in A1c (HbA1c) tells the average level of blood sugar over the prior 2 to 3 months. Normal level is below 5.7%; 5.7%-6.4% indicates prediabetes; greater than 6.5% is indicative of diabetes. (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | % of hemoglobin a1c (Mean) |
|---|---|
| Group A: SRP + SPT | -0.01 |
| Group B: SRP | 0.14 |
Hemoglobin in A1c (HbA1c) tells the average level of blood sugar over the prior 2 to 3 months. Normal level is below 5.7%; 5.7%-6.4% indicates prediabetes; greater than 6.5% is indicative of diabetes. (NCT04830969)
Timeframe: Baseline to 6 months
| Intervention | % of hemoglobin a1c (Mean) |
|---|---|
| Diabetic + SRP + SPT | -0.04 |
| Diabetic + SRP | 0.30 |
| Non-Diabetic + SRP + SPT | 0.01 |
| Non-Diabetic + SRP | -0.07 |
The analysis is based on the measures of each participant. Participant instead of site is used as unite for arm/group. The measure, % sites with probing pocket depth >= 4 mm within each participant, indicates the portion of deep pocket in a participant. Periodontal PD in millimeters is measured with a UNC-15 periodontal probe on 6 sites per tooth; The percentage of sites with Periodontal PD >= 4 mm within each participant was compared between measured time points. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | % sites with PD >= 4 mm of a participant (Mean) | |
|---|---|---|
| Baseline to 3-month | Baseline to 6-month | |
| Group A: SRP + SPT | -8.71 | -7.03 |
| Group B: SRP | -4.74 | -4.73 |
The analysis is based on the measure of each participant. Periodontal PD in millimeters is measured with a UNC-15 periodontal probe on 6 sites per tooth; The percentage of sites with Periodontal PD >= 4 mm per participant is compared between measured time points. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | % sites with PD >= 4 mm of a participant (Mean) | |
|---|---|---|
| Baseline to 3-month | Baseline to 6-month | |
| Diabetic + SRP | -4.22 | 4.12 |
| Diabetic + SRP + SPT | -10.23 | -7.85 |
| Non-Diabetic + SRP | -5.4 | -5.52 |
| Non-Diabetic + SRP + SPT | -7.39 | -6.3 |
The analysis is based on the measures of each participant. Plaque is visually measured on 6 sites per tooth; 0 is the absence of any plaque. 1 is the presence of plaque. For each participant, 6 sites per tooth are evaluated. The Plaque Index (PI) of each participant is defined as the percentage of sites with plaque. The value of PI ranges from 0 to 100 for each participant. The PI of each participant is assessed and compared between measured time points. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | Plaque Index of a participant (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Group A: SRP + SPT | -14.76 | 9.68 |
| Group B: SRP | -7.7 | -5.19 |
The analysis is based on the measures of each participant. Plaque is visually measured on 6 sites per tooth; 0 is the absence of any plaque. 1 is the presence of plaque. For each participant, 6 sites per tooth are evaluated. The Plaque Index (PI) of each participant is defined as the percentage of sites with plaque. The value of PI ranges from 0 to 100 for each participant. The PI of each participant is assessed and compared between measured time points. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | Plaque Index of a participant (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Diabetic + SRP | -7.67 | -4.97 |
| Diabetic + SRP + SPT | -17.46 | -12.11 |
| Non-Diabetic + SRP | -7.75 | -5.48 |
| Non-Diabetic + SRP + SPT | -12.4 | -7.56 |
Probing depth (PD) or probing pocket depth (PPD), measured on six surfaces/tooth, is the distance in millimeters (mm) from the gingival margin to the base of the gingival pocket (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | mm (Mean) | |
|---|---|---|
| Baseline to 3-month | Baseline to 6-month | |
| Diabetic + SRP | -0.17 | -0.12 |
| Diabetic + SRP + SPT | -0.36 | -0.27 |
| Non-Diabetic + SRP | -0.27 | -0.26 |
| Non-Diabetic + SRP + SPT | -0.26 | -0.24 |
The analysis is based on the measures of each participant. 0 is the absence of gingival bleeding and 1 is the presence of gingival bleeding after probing and measuring for pocket depth. Bleeding on probing index is defined as the percentage of sites with presence of gingival bleeding after probing per participant. The value of bleeding on probing index ranges from 0 to 100 for each participant. The bleeding on probing index per participant is compared between time points measured. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | BOP index of a participant (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Group A: SRP + SPT | -13.24 | -8.93 |
| Group B: SRP | -5.57 | -4.09 |
The analysis is based on the measures of each participant. 0 is the absence of gingival bleeding and 1 is the presence of gingival bleeding after probing and measuring for pocket depth. Bleeding on probing index is defined as the percentage of sites with presence of gingival bleeding after probing per participant. The value of bleeding on probing index ranges from 0 to 100 for each participant. The bleeding on probing index per participant is compared between time points measured. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | BOP index of a participant (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Diabetic + SRP | -4.35 | -1.95 |
| Diabetic + SRP + SPT | -13.45 | -9.62 |
| Non-Diabetic + SRP | -7.13 | -6.82 |
| Non-Diabetic + SRP + SPT | -13.06 | -8.32 |
The distance from the Cemento-enamel Junction (CEJ) to the free gingival margin is measured with a periodontal probe. Millimeters of recession (loss of attachment) is recorded as a negative number; when the gingival margin is above the CEJ, the measurement (in millimeters) is recorded as positive. (NCT04830969)
Timeframe: Baseline to 3 months;Baseline to 6 months
| Intervention | mm (Mean) | |
|---|---|---|
| Baseline to 3-month | Baseline to 6-month | |
| Group A: SRP + SPT | -0.1 | -0.1 |
| Group B: SRP | -0.2 | -0.12 |
The distance from the Cemento-enamel Junction (CEJ) to the free gingival margin is measured with a periodontal probe. Millimeters of recession (loss of attachment) is recorded as a negative number; when the gingival margin is above the CEJ, the measurement (in millimeters) is recorded as positive. (NCT04830969)
Timeframe: Baseline to 3 months; Baseline to 6 months
| Intervention | mm (Mean) | |
|---|---|---|
| Baseline to 3 months | Baseline to 6 months | |
| Diabetic + SRP | -0.17 | -0.06 |
| Diabetic + SRP + SPT | -0.11 | -0.14 |
| Non-Diabetic + SRP | -0.23 | -0.19 |
| Non-Diabetic + SRP + SPT | -0.1 | -0.07 |
Shannon index represents mean species diversity in a site at a local scale. Shannon index quantifies the uncertainty in predicting the species identity of an individual that is taken at random from the dataset. The minimum value is 0 and there is no maximum value. High values mean high species diversities. (NCT04830969)
Timeframe: Baseline; 6 Months
| Intervention | Shannon index value (Mean) | |
|---|---|---|
| Baseline | 6 Months | |
| Group A: SRP + SPT | 5.31 | 5.2 |
| Group B: SRP | 5.27 | 5.34 |
Attachment loss were recorded at baseline, 1st, 3rd and 6th months as millimeters. The data were compared among and between groups. (NCT02223702)
Timeframe: 6-months
| Intervention | mm (Mean) | |||
|---|---|---|---|---|
| Baseline | 1st month | 3rd month | 6th month | |
| Amoxicillin+Metronidazole | 5.03 | 4.37 | 4.41 | 4.33 |
| Moxifloxacin | 4.94 | 4.14 | 3.98 | 4.30 |
We measured the probing depth at baseline, 1st, 3rd and 6th months. The changes were evaluated among and between groups. (NCT02223702)
Timeframe: 6-months
| Intervention | mm (Mean) | |||
|---|---|---|---|---|
| Baseline | 1st month | 3rd month | 6th month | |
| Amoxicillin+Metronidazole | 4.57 | 3.12 | 3.11 | 3.15 |
| Moxifloxacin | 4.18 | 2.91 | 2.79 | 3.01 |
41 reviews available for metronidazole and Periodontitis
| Article | Year |
|---|---|
Efficacy of Systemic Amoxicillin-Metronidazole in Periodontitis Patients with Diabetes Mellitus: A Systematic Review of Randomized Clinical Trials.
Topics: Amoxicillin; Anti-Bacterial Agents; Clindamycin; Diabetes Mellitus, Type 2; Humans; Metronidazole; P | 2022 |
Unraveling the effectiveness of antibiotics for peri-implantitis treatment: A scoping review.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Implants; Humans; Metronidazole; Peri-Implantitis; Period | 2023 |
Adjunctive effect of systemic antimicrobials in periodontitis therapy: A systematic review and meta-analysis.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Dental Scaling; Humans; Metronidazole; Pe | 2020 |
Adjunctive effect of systemic antimicrobials in periodontitis therapy: A systematic review and meta-analysis.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Dental Scaling; Humans; Metronidazole; Pe | 2020 |
Adjunctive effect of systemic antimicrobials in periodontitis therapy: A systematic review and meta-analysis.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Dental Scaling; Humans; Metronidazole; Pe | 2020 |
Adjunctive effect of systemic antimicrobials in periodontitis therapy: A systematic review and meta-analysis.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Dental Scaling; Humans; Metronidazole; Pe | 2020 |
Primer on etiology and treatment of progressive/severe periodontitis: A systemic health perspective.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Dental Scaling; Humans; Metronidaz | 2020 |
Antimicrobial photodynamic therapy compared to systemic antibiotic therapy in non-surgical treatment of periodontitis: Systematic review and meta-analysis.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Chronic Periodontitis; Combined Modality Therapy; Dent | 2020 |
The effect of drug dose and duration of adjuvant Amoxicillin-plus-Metronidazole to full-mouth scaling and root planing in periodontitis: a systematic review and meta-analysis.
Topics: Amoxicillin; Anti-Bacterial Agents; Chronic Periodontitis; Dental Scaling; Humans; Metronidazole; Pe | 2021 |
Optimal dose and duration of amoxicillin-plus-metronidazole as an adjunct to non-surgical periodontal therapy: A systematic review and meta-analysis of randomized, placebo-controlled trials.
Topics: Amoxicillin; Anti-Bacterial Agents; Combined Modality Therapy; Drug Therapy, Combination; Humans; Me | 2018 |
Microbial colonization of the periodontal pocket and its significance for periodontal therapy.
Topics: Amoxicillin; Anti-Bacterial Agents; Bacteria; Bacterial Physiological Phenomena; Biodiversity; Denta | 2018 |
The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =a systematic review=.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; Periodontal Pocket; Perio | 2016 |
The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =a systematic review=.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; Periodontal Pocket; Perio | 2016 |
The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =a systematic review=.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; Periodontal Pocket; Perio | 2016 |
The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =a systematic review=.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; Periodontal Pocket; Perio | 2016 |
Does adjunctive antimicrobial therapy reduce the perceived need for periodontal surgery?
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Chemotherapy, Adjuvant; Drug Combi | 2011 |
Selection of antimicrobial agents in periodontal therapy.
Topics: Administration, Topical; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Ciproflox | 2002 |
Rationale for use of antibiotics in periodontics.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial | 2002 |
Local anti-infective therapy: pharmacological agents. A systematic review.
Topics: Alkaloids; Anti-Bacterial Agents; Anti-Infective Agents, Local; Benzophenanthridines; Chlorhexidine; | 2003 |
Systemic anti-infective periodontal therapy. A systematic review.
Topics: Administration, Oral; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Age | 2003 |
Topical and systemic antibiotics in the management of periodontal diseases.
Topics: Actinobacillus Infections; Administration, Oral; Administration, Topical; Aggregatibacter actinomyce | 2004 |
Meta-analysis of local metronidazole in the treatment of chronic periodontitis.
Topics: Administration, Topical; Adult; Anti-Infective Agents, Local; Chronic Disease; Dental Scaling; Human | 2004 |
[Impact of antibiotics on the indication for periodontal surgery].
Topics: Administration, Oral; Anti-Infective Agents; Humans; Metronidazole; Oral Surgical Procedures; Period | 2004 |
Impact of local adjuncts to scaling and root planing in periodontal disease therapy: a systematic review.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents, Local; Chemotherapy, Adjuvant; Chlorhexidine; C | 2005 |
Diagnosis and anti-infective therapy of periodontitis.
Topics: Amoxicillin; Animals; Anti-Infective Agents; Chlorhexidine; Clindamycin; Humans; Metronidazole; Micr | 2007 |
Locally delivered antimicrobials in the management of periodontitis: a critical review of the evidence for their use in practice.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Combined Modality Therapy; Drug Implants; Hum | 2007 |
Necrotizing periodontal diseases in HIV-seropositive subjects: pathogenic mechanisms.
Topics: Anti-Infective Agents; Candida albicans; Chlorhexidine; Cytokines; Dental Scaling; Gingivitis, Necro | 2008 |
[Metronidazole--an antibiotic for subgingival chemical plaque control?].
Topics: Animals; Clinical Trials as Topic; Dental Plaque; Drug Evaluation, Preclinical; Gingival Diseases; H | 1983 |
Metronidazole: its use in clinical dentistry.
Topics: Aggressive Periodontitis; Bacteria, Anaerobic; Drug Interactions; Gingivitis; Humans; Kinetics; Metr | 1984 |
[Topical application of antimicrobial agents in periodontics. Current status of the problem].
Topics: Administration, Topical; Adolescent; Adult; Anti-Infective Agents, Local; Child; Gels; Humans; Metro | 1994 |
Pharmacological control of periodontal disease. II. Antimicrobial agents.
Topics: Adult; Anti-Bacterial Agents; Child; Humans; Metronidazole; Periodontal Diseases; Periodontal Pocket | 1995 |
The role of metronidazole in the treatment of periodontal diseases.
Topics: Animals; Bacteria, Anaerobic; Carcinogenicity Tests; Drug Interactions; Humans; Metronidazole; Molec | 1993 |
Antimicrobial therapy in periodontics.
Topics: Amoxicillin; Anti-Bacterial Agents; Ciprofloxacin; Clinical Protocols; Dental Prophylaxis; Drug Deli | 1993 |
The role of antibiotics in the treatment of periodontitis (Part 2--Controlled drug delivery).
Topics: Anti-Bacterial Agents; Delayed-Action Preparations; Drug Delivery Systems; Gels; Humans; Metronidazo | 1995 |
The role of antibiotics in the treatment of periodontitis. (Part I--Systemic delivery.
Topics: Adult; Anti-Bacterial Agents; Delayed-Action Preparations; Drug Therapy, Combination; Humans; Metron | 1994 |
Microbiological response to mechanical treatment in combination with adjunctive therapy. A review of the literature.
Topics: Administration, Oral; Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Anti-Ba | 1996 |
Meta-analysis of the effect of systemic metronidazole as an adjunct to scaling and root planing for adult periodontitis.
Topics: Adult; Anti-Infective Agents; Combined Modality Therapy; Confidence Intervals; Dental Scaling; Dose- | 1997 |
Controlled local delivery of antimicrobials in the treatment of periodontitis.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Doxycycli | 1998 |
Comparison of the clinical effects of subgingival application of metronidazole 25% gel and scaling in the treatment of adult periodontitis.
Topics: Adult; Analysis of Variance; Anti-Bacterial Agents; Antitrichomonal Agents; Dental Plaque; Dental Pl | 1998 |
The role of local drug delivery in the management of periodontal diseases: a comprehensive review.
Topics: Administration, Topical; Anti-Bacterial Agents; Anti-Infective Agents, Local; Antitrichomonal Agents | 1998 |
Systemic antibiotic therapy in severe periodontitis.
Topics: Administration, Oral; Amoxicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Humans; Metroni | 1997 |
Chemical treatment of periodontitis: local delivery of antimicrobials.
Topics: Administration, Topical; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; | 1998 |
The use of locally delivered metronidazole in the treatment of periodontitis. Clinical results.
Topics: Administration, Topical; Anti-Infective Agents, Local; Chemotherapy, Adjuvant; Clinical Trials as To | 1998 |
Local delivery of antimicrobial agents for the treatment of periodontitis.
Topics: Anti-Bacterial Agents; Anti-Infective Agents, Local; Chlorhexidine; Delayed-Action Preparations; Dox | 1998 |
The supplemental use of antibiotics in periodontal therapy.
Topics: Administration, Oral; Administration, Topical; Amoxicillin-Potassium Clavulanate Combination; Anti-B | 1999 |
Diagnosis and management of HIV-associated periodontal lesions.
Topics: Chlorhexidine; Dental Care for Disabled; Dental Scaling; Gingivitis; Gingivitis, Necrotizing Ulcerat | 1989 |
Current concepts in periodontal diseases.
Topics: Acute Disease; Adult; Child; Chronic Disease; Dental Plaque; Gingivitis; Gingivitis, Necrotizing Ulc | 1985 |
114 trials available for metronidazole and Periodontitis
| Article | Year |
|---|---|
Adjunctive efficacy of systemic metronidazole in the surgical treatment of periodontitis: a double-blind parallel randomized clinical trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Double-Blind Method; Humans; Metronidazole; Peri | 2022 |
Effect of systemic antibiotic and probiotic therapies as adjuvant treatments of subgingival instrumentation for periodontitis: a randomized controlled clinical study.
Topics: Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; Periodontitis; Probiotics | 2022 |
Microbiological effects of amoxicillin plus metronidazole in the treatment of young patients with Stages III and IV periodontitis: A secondary analysis from a 1-year double-blinded placebo-controlled randomized clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Combined Modality Therapy; Dental Plaque; Dental Scaling; | 2023 |
Long-term changes in the subgingival microbiota in patients with stage III-IV periodontitis treated by mechanical therapy and adjunctive systemic antibiotics: A secondary analysis of a randomized controlled trial.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Humans; Metronidazole; Mi | 2023 |
Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis stage and grade: An exploratory sub-analysis of the ABPARO trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Male; Metronidazole; Periodontal Pocket; | 2023 |
Efficacy of clindamycin compared with amoxicillin-metronidazole after a 7-day regimen in the treatment of periodontitis in patients with diabetes: a randomized clinical trial.
Topics: Adolescent; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Clindamycin; Diabetes Mellitus, Type 2; | 2020 |
Effects on clinical outcomes of adjunctive moxifloxacin versus amoxicillin plus metronidazole in periodontitis patients harboring Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Tannerella forsythia: exploratory analyses from a clinic
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Humans; Metronidaz | 2021 |
Metronidazole and amoxicillin for patients with periodontitis and diabetes mellitus: 5-year secondary analysis of a randomized controlled trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Diabetes Mellitus; Humans; Metronidazole; Period | 2021 |
Microbiological and host-derived biomarker evaluation following non-surgical periodontal therapy with short-term administration of systemic antimicrobials: secondary outcomes of an RCT.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Infective Agents; Biomarkers; Drug A | 2020 |
[Study on the efficacy and safety of metronidazole combined with periodontal tissue regeneration in the treatment of periodontitis].
Topics: Combined Modality Therapy; Humans; Metronidazole; Periodontal Index; Periodontitis; Periodontium | 2020 |
Effect of adjunctive systemic antibiotics on microbial populations compared with scaling and root planing alone for the treatment of periodontitis: A pilot randomized clinical trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Glucose; Humans; Metronidazole; Periodontitis; P | 2022 |
Doxycycline hydrochloride-metronidazole solid lipid microparticles gels for treatment of periodontitis: development, in-vitro and in-vivo clinical evaluation.
Topics: Adult; Anti-Bacterial Agents; Dental Scaling; Double-Blind Method; Doxycycline; Drug Combinations; F | 2017 |
One year results of a randomized controlled clinical study evaluating the effects of non-surgical periodontal therapy of chronic periodontitis in conjunction with three or seven days systemic administration of amoxicillin/metronidazole.
Topics: Adult; Amoxicillin; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Metronidazole; | 2017 |
A double-masked Randomized Clinical Trial (RCT) comparing four periodontitis treatment strategies: 5-year clinical results.
Topics: Adult; Aged; Anti-Infective Agents, Local; Chlorhexidine; Dental Plaque Index; Dental Scaling; Doubl | 2017 |
The ideal time of systemic metronidazole and amoxicillin administration in the treatment of severe periodontitis: study protocol for a randomized controlled trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Brazil; Dental Scaling; Double-Blind Method; Drug Adminis | 2018 |
Clinical benefits of systemic amoxicillin/metronidazole may depend on periodontitis severity and patients' age: An exploratory sub-analysis of the ABPARO trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Humans; Metronidazole; Periodontal Attachment Lo | 2019 |
Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg-Th17 Plasticity in Periodontitis.
Topics: Amoxicillin; Bacteria; Bacterial Infections; Dendritic Cells; Female; Humans; Male; Metronidazole; M | 2019 |
Baseline adjustment and change revisited: effect of smoking on change in periodontal status following periodontal therapy.
Topics: Adult; Age Factors; Aged; Analysis of Variance; Anti-Infective Agents; Bias; Combined Modality Thera | 2014 |
Differential benefits of amoxicillin-metronidazole in different phases of periodontal therapy in a randomized controlled crossover clinical trial.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Combined Mod | 2015 |
Clinical picture of combination therapy (metronidazole sustained release film with minocycine hydrochloride) in periodontitis.
Topics: Adolescent; Adult; Aged; Delayed-Action Preparations; Drug Therapy, Combination; Female; Humans; Mal | 2015 |
Is progression of periodontitis relevantly influenced by systemic antibiotics? A clinical randomized trial.
Topics: Amoxicillin; Anti-Bacterial Agents; Disease Progression; Double-Blind Method; Drug Therapy, Combinat | 2015 |
Effect of Periodontal Therapy With Amoxicillin-Metronidazole on Pharyngeal Carriage of Penicillin- and Erythromycin-Resistant Viridans Streptococci.
Topics: Amoxicillin; Anti-Bacterial Agents; Drug Resistance, Bacterial; Erythromycin; Humans; Metronidazole; | 2016 |
Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Dental Plaque; Dental Sc | 2016 |
Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Dental Plaque; Dental Sc | 2016 |
Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Dental Plaque; Dental Sc | 2016 |
Amoxicillin Plus Metronidazole Therapy for Patients with Periodontitis and Type 2 Diabetes: A 2-year Randomized Controlled Trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Biofilms; Dental Plaque; Dental Sc | 2016 |
A Randomized Double-Masked Clinical Trial Comparing Four Periodontitis Treatment Strategies: 5-Year Tooth Loss Results.
Topics: Adult; Aged; Anti-Infective Agents, Local; Chlorhexidine; Dental Scaling; Disinfection; Double-Blind | 2017 |
Systemic administration of doxycycline versus metronidazole plus amoxicillin in the treatment of localized aggressive periodontitis: a clinical and microbiologic study.
Topics: Administration, Oral; Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Ba | 2008 |
[Therapeutic effects of three topical remedies on periodontitis].
Topics: Administration, Topical; Adult; Aged; Anti-Bacterial Agents; Female; Humans; Iodine; Male; Metronida | 2010 |
Effects of periodontal therapy on systemic markers of inflammation in patients with metabolic syndrome: a controlled clinical trial.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Atherosclerosis; Biomarkers; Blood Glucose; Body Ma | 2012 |
Are there specific benefits of amoxicillin plus metronidazole in Aggregatibacter actinomycetemcomitans-associated periodontitis? Double-masked, randomized clinical trial of efficacy and safety.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infecti | 2013 |
A randomized, double-masked clinical trial comparing four periodontitis treatment strategies: 1-year clinical results.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Combined Modality T | 2013 |
Local antimicrobial therapy after initial periodontal treatment.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Analysis of Variance; Anti-Bacterial Agents; Ant | 2002 |
Antibiotic resistance of subgingival species during and after antibiotic therapy.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteria, Anaerobic; Colony Count, Microbial; Dental Plaq | 2002 |
Effects of non-surgical treatment modalities on peri-implantitis.
Topics: Adult; Anti-Infective Agents; Carbon; Dental Implants; Female; Humans; Male; Metronidazole; Middle A | 2002 |
Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis; 12-months results.
Topics: Administration, Topical; Adult; Analysis of Variance; Anti-Bacterial Agents; Colony Count, Microbial | 2001 |
Clinical evaluation of subgingival application of metronidazole 25%, and adjunctive therapy.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Combined Modality Therapy; Dental Plaqu | 2000 |
Periodontal disease and preterm birth: results of a pilot intervention study.
Topics: Adult; Anti-Infective Agents; Dental Scaling; Double-Blind Method; Feasibility Studies; Female; Huma | 2003 |
Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients.
Topics: Adult; Anti-Infective Agents, Local; Case-Control Studies; Chlorhexidine; Chronic Disease; Colony Co | 2004 |
Intraoral dissemination of treponemes after periodontal therapy.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidi | 2004 |
[A comparison between the effects of periocline and yakang on the treatment of periodontitis].
Topics: Anti-Bacterial Agents; Humans; Metronidazole; Minocycline; Ointments; Periodontitis | 2004 |
Periodontal treatment of patients with Papillon-Lefèvre syndrome: a 3-year follow-up.
Topics: Adolescent; Amoxicillin; Anti-Bacterial Agents; Child; Dental Care for Chronically Ill; Dental Scali | 2004 |
Scaling and root planing, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population. I. clinical results.
Topics: Adult; Analysis of Variance; Anti-Infective Agents; Chronic Disease; Combined Modality Therapy; Dent | 2004 |
Concentrations and in vivo antibacterial activity of spiramycin and metronidazole in patients with periodontitis treated with high-dose metronidazole and the spiramycin/metronidazole combination.
Topics: Drug Therapy, Combination; Gingival Crevicular Fluid; Humans; Metronidazole; Microbial Sensitivity T | 2005 |
Enamel matrix proteins and systemic antibiotics as adjuncts to non-surgical periodontal treatment: clinical effects.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bone Density; Chronic Diseas | 2005 |
Periodontal dressing (Vocopac) influences outcomes in a two-step treatment procedure.
Topics: Administration, Oral; Adult; Anti-Infective Agents; Dental Scaling; Female; Humans; Male; Metronidaz | 2005 |
Scaling and root planing, systemic metronidazole and professional plaque removal in the treatment of chronic periodontitis in a Brazilian population II--microbiological results.
Topics: Administration, Oral; Adult; Anti-Infective Agents; Bacteria, Anaerobic; Bacterial Typing Techniques | 2005 |
Adjunctive antimicrobial therapy of periodontitis: long-term effects on disease progression and oral colonization.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents | 2005 |
Enhanced root planing and systemic metronidazole administration improve clinical and microbiological outcomes in a two-step treatment procedure.
Topics: Adult; Anti-Infective Agents; Combined Modality Therapy; Female; Humans; Male; Metronidazole; Period | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial.
Topics: Adolescent; Adult; Algorithms; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Hu | 2005 |
Oral health impacts on daily living related to four different treatment protocols for chronic periodontitis.
Topics: Activities of Daily Living; Adult; Anti-Infective Agents; Chronic Disease; Dental Prophylaxis; Doubl | 2005 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Local oxygen therapy for treating acute necrotizing periodontal disease in smokers.
Topics: Acute Disease; Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin-Po | 2006 |
Enamel matrix derivative and systemic antibiotics as adjuncts to non-surgical periodontal treatment: biologic response.
Topics: Adult; Aged; Amoxicillin; Anti-Infective Agents; Dental Enamel Proteins; Dental Scaling; Female; Gin | 2006 |
Application of chitosan gel in the treatment of chronic periodontitis.
Topics: Adult; Anti-Infective Agents, Local; Biocompatible Materials; Chitosan; Chronic Disease; Dental Mate | 2007 |
Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Case-Control Studi | 2006 |
Repeated oral hygiene instructions alone, or in combination with metronidazole dental gel with or without subgingival scaling in adult periodontitis patients: a one-year clinical study.
Topics: Adult; Anti-Infective Agents; Dental Scaling; Epidemiologic Methods; Female; Humans; Male; Metronida | 2006 |
[Comparison of antibacterial efficacy of 1 and 25% concentration of Metrogil-denta for inflammatory periodontal disease treatment].
Topics: Adult; Aged; Anti-Infective Agents; Bacteria, Aerobic; Bacteria, Anaerobic; Bacterial Infections; Ch | 2006 |
Clinical changes following four different periodontal therapies for the treatment of chronic periodontitis: 1-year results.
Topics: Adult; Aged; Anti-Bacterial Agents; Azithromycin; Chronic Disease; Combined Modality Therapy; Dental | 2007 |
Adjunctive effects of systemic amoxicillin and metronidazole with scaling and root planing: a randomized, placebo controlled clinical trial.
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Analysis of Varianc | 2007 |
Topical use of a metronidazole gel in the treatment of sites with symptoms of recurring chronic inflammation.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Chronic Disease; Delayed-Action Prepara | 2007 |
Comparison between full-mouth scaling and root planing and quadrant-wise basic therapy of aggressive periodontitis: 6-month clinical results.
Topics: Adolescent; Adult; Amoxicillin; Anti-Infective Agents, Local; Chlorhexidine; Dental Scaling; Drug Co | 2007 |
Controlled-delivery chlorhexidine chip versus amoxicillin/metronidazole as adjunctive antimicrobial therapy for generalized aggressive periodontitis: a randomized controlled clinical trial.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Chlorhexidine; Delayed-Acti | 2007 |
Microbiological changes associated with four different periodontal therapies for the treatment of chronic periodontitis.
Topics: Adult; Anti-Infective Agents; Azithromycin; Chronic Disease; Dental Plaque; Dental Scaling; Doxycycl | 2008 |
[Metronidazole--an antibiotic for subgingival chemical plaque control?].
Topics: Animals; Clinical Trials as Topic; Dental Plaque; Drug Evaluation, Preclinical; Gingival Diseases; H | 1983 |
Effect of combined systemic antimicrobial therapy and mechanical plaque control in patients with recurrent periodontal disease.
Topics: Adult; Aged; Bacteria; Combined Modality Therapy; Dental Plaque; Dental Prophylaxis; Female; Humans; | 1984 |
A comparative clinical study: the use of human type I collagen with and without the addition of metronidazole in the GTR method of treatment of periodontal disease.
Topics: Adult; Anti-Infective Agents, Local; Collagen; Dental Plaque Index; Dental Prophylaxis; Dental Scali | 1995 |
Metronidazole in periodontitis V: debridement should precede medication.
Topics: Adult; Analysis of Variance; Bacteria, Anaerobic; Clinical Protocols; Dental Plaque; Dental Scaling; | 1994 |
Combination of tetracycline and metronidazole in the treatment and control of refractory periodontitis.
Topics: Adult; Chronic Disease; Dental Scaling; Drug Therapy, Combination; Female; Humans; Male; Metronidazo | 1994 |
Microbiological and clinical effects of metronidazole and amoxicillin in Actinobacillus actinomycetemcomitans-associated periodontitis. A 2-year evaluation.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Bacteroides; Dental Plaque; Dental Plaque Index; | 1994 |
Topical metronidazole as an adjunct to subgingival debridement in the treatment of chronic periodontitis.
Topics: Adult; Aged; Chronic Disease; Collagen; Delayed-Action Preparations; Dental Plaque Index; Female; Hu | 1994 |
Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters.
Topics: Alveolar Bone Loss; Colony Count, Microbial; Dental Plaque; Dental Scaling; Double-Blind Method; Fem | 1993 |
Topical metronidazole application compared with subgingival scaling. A clinical and microbiological study on recall patients.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents, Local; Bacteria; Colony Count, Microbia | 1996 |
Value of some laboratory and clinical measurements in the treatment plan for advanced periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Anti-Bacterial Agents; Denta | 1996 |
A clinical and microbiological evaluation of systemic and local metronidazole delivery in adult periodontitis patients.
Topics: Administration, Oral; Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Anti-In | 1997 |
Effects of combined topical metronidazole and mechanical treatment on the subgingival flora in deep periodontal pockets in cuspids and bicuspids.
Topics: Administration, Oral; Administration, Topical; Adult; Aged; Aggregatibacter actinomycetemcomitans; A | 1997 |
Topical metronidazole application in recall patients. Long-term results.
Topics: Administration, Topical; Adult; Aged; Anti-Bacterial Agents; Bacteria; Dental Plaque; Dental Scaling | 1997 |
Differential effects of systemic metronidazole and amoxicillin on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in intraoral habitats.
Topics: Administration, Oral; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agen | 1998 |
A clinical and microbiological evaluation of systemic and local metronidazole delivery in early onset periodontitis patients.
Topics: Administration, Oral; Administration, Topical; Adult; Anti-Bacterial Agents; Bacteria; Combined Moda | 1996 |
[The effect of tinidazole in the treatment of adult periodontitis].
Topics: Adult; Anti-Bacterial Agents; Bacteroidaceae Infections; Female; Humans; Male; Metronidazole; Middle | 1996 |
Comparison of the clinical effects of subgingival application of metronidazole 25% gel and scaling in the treatment of adult periodontitis.
Topics: Adult; Analysis of Variance; Anti-Bacterial Agents; Antitrichomonal Agents; Dental Plaque; Dental Pl | 1998 |
The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Biopsy; Combined M | 1998 |
Differential clinical treatment outcome after systemic metronidazole and amoxicillin in patients harboring Actinobacillus actinomycetemcomitans and/or Porphyromonas gingivalis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 1998 |
Adjunctive systemic and locally delivered metronidazole in the treatment of periodontitis: a controlled clinical study.
Topics: Administration, Oral; Administration, Topical; Adult; Aged; Analysis of Variance; Antitrichomonal Ag | 1998 |
Effects of topical metronidazole and tetracycline in treatment of adult periodontitis.
Topics: Administration, Topical; Adult; Aged; Aggregatibacter actinomycetemcomitans; Analysis of Variance; A | 1998 |
Local metronidazole application in maintenance patients. Clinical and microbiological evaluation.
Topics: Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Colony | 1998 |
Effects of metronidazole plus amoxicillin in progressive untreated adult periodontitis: results of a single 1-week course after 2 and 4 months.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Analysis of Variance; Anti-Bacteria | 1998 |
Non-surgical periodontal treatment with and without adjunctive metronidazole in smokers and non-smokers.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Anti-Bacterial Agents; Chemotherapy, Adjuva | 1999 |
Longitudinal effect of non-surgical treatment and systemic metronidazole for 1 week in smokers and non-smokers with refractory periodontitis: a 5-year study.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Dental Scaling; Double-Blind Me | 1999 |
Clonal infection with Actinobacillus actinomycetemcomitans following periodontal therapy.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Bacterial Outer Me | 1999 |
Protective effect of serum antibodies against a 110-kilodalton protein of Actinobacillus actinomycetemcomitans following periodontal therapy.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Antibodies, Bacter | 1999 |
Repeated local metronidazole-therapy as adjunct to scaling and root planing in maintenance patients.
Topics: Administration, Topical; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Colony Count, | 1999 |
Repeated metronidazole and amoxicillin treatment of periodontitis. A follow-up study.
Topics: Adult; Aged; Amoxicillin; Analysis of Variance; Anti-Infective Agents; Chronic Disease; Disease Prog | 2000 |
Periodontal flap surgery with 25% metronidazole gel. (2). Effect on gingival crevicular fluid PGE2.
Topics: Administration, Topical; Adult; Analysis of Variance; Anti-Infective Agents; Combined Modality Thera | 2000 |
Periodontal flap surgery with 25% metronidazole gel. (1). Clinical outcomes.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Combined Modality Therapy; Confidence I | 2000 |
[Adjuvant antibiotic therapy as a 2-step treatment concept in early-onset periodontitis: a strategy for eradication of bacteria that cause periodontitis].
Topics: Administration, Oral; Adolescent; Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Bacteria; Chemot | 2000 |
Comparison of clinical outcomes following treatment of chronic adult periodontitis with subgingival scaling or subgingival scaling plus metronidazole gel.
Topics: Adult; Anti-Infective Agents, Local; Chronic Disease; Dental Scaling; Double-Blind Method; Female; G | 2000 |
Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteroides; Dental Plaque; Double-Blind Method; Drug Com | 2001 |
A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Clindamycin; Clinical Protocols | 2001 |
[Metronidazole in the treatment of refractory periodontitis].
Topics: Adult; Anti-Infective Agents; Combined Modality Therapy; Dental Scaling; Female; Humans; Male; Metro | 2000 |
Aggressive periodontitis: 5-year follow-up of treatment.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Dental Plaque; Den | 2002 |
Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Bacteria; Bacteroides; Delayed-Action Preparatio | 1992 |
3 regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults.
Topics: Adult; Aged; Delayed-Action Preparations; Dental Scaling; Drug Implants; Female; Follow-Up Studies; | 1992 |
Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis.
Topics: Adult; Aged; Delayed-Action Preparations; Dental Scaling; Drug Implants; Female; Follow-Up Studies; | 1992 |
Serial doxycycline and metronidazole in prevention of recurrent periodontitis in high-risk patients.
Topics: Bacteria; Dental Plaque Index; Dental Scaling; Doxycycline; Drug Therapy, Combination; Female; Human | 1992 |
Metronidazole in periodontitis: reduced need for surgery.
Topics: Adult; Alveolar Bone Loss; Bacteria; Bacteroidaceae; Bacteroides; Colony Count, Microbial; Combined | 1992 |
Effects of metronidazole on periodontal treatment needs.
Topics: Alveolar Bone Loss; Bacteria; Dental Plaque; Dental Scaling; Double-Blind Method; Female; Humans; Ma | 1991 |
The effects of subgingival irrigation with low dosage metronidazole on periodontal inflammation.
Topics: Administration, Topical; Adult; Chronic Disease; Dental Plaque Index; Double-Blind Method; Humans; M | 1991 |
The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults.
Topics: Adult; Bone Resorption; Clinical Trials as Topic; Dental Prophylaxis; Dental Scaling; Double-Blind M | 1990 |
The utility of the BANA test for monitoring anaerobic infections due to spirochetes (Treponema denticola) in periodontal disease.
Topics: Analysis of Variance; Benzoylarginine-2-Naphthylamide; Dental Plaque; Double-Blind Method; Humans; M | 1990 |
[Influence of systemic metronidazole therapy on the flora of the periodontal gingival pocket].
Topics: Humans; Metronidazole; Periodontal Pocket; Periodontitis | 1989 |
The role of adjunctive Rodogyl therapy in the treatment of advanced periodontal disease. A longitudinal clinical and microbiologic study.
Topics: Adult; Anti-Bacterial Agents; Bacteria; Clinical Trials as Topic; Combined Modality Therapy; Dental | 1987 |
The value of systemically administered metronidazole in the modified Widman flap procedure.
Topics: Adult; Bacteria; Double-Blind Method; Epithelial Attachment; Female; Humans; Male; Metronidazole; Mi | 1987 |
The effects of a simplified oral hygiene regime plus supragingival irrigation with chlorhexidine or metronidazole on chronic inflammatory periodontal disease.
Topics: Adult; Chlorhexidine; Chronic Disease; Dental Devices, Home Care; Dental Plaque Index; Dental Scalin | 1986 |
Metronidazole: a double-blind trial in untreated human periodontal disease.
Topics: Adult; Bacteria; Cell Movement; Clinical Trials as Topic; Dental Plaque; Double-Blind Method; Female | 1986 |
A follow-up study 3 years after metronidazole therapy for chronic periodontal disease.
Topics: Chronic Disease; Dental Plaque; Dental Scaling; Follow-Up Studies; Gingival Hemorrhage; Humans; Metr | 1986 |
Effects of short-term administration of metronidazole on the subgingival microflora.
Topics: Adult; Aged; Bacteria; Dental Scaling; Female; Gingiva; Gingival Crevicular Fluid; Humans; Male; Met | 1985 |
180 other studies available for metronidazole and Periodontitis
| Article | Year |
|---|---|
Inhibition of Porphyromonas gingivalis biofilm by oxantel.
Topics: Biofilms; Humans; Microbial Sensitivity Tests; Microscopy, Confocal; Periodontitis; Plankton; Porphy | 2010 |
Personalized and Defect-Specific Antibiotic-Laden Scaffolds for Periodontal Infection Ablation.
Topics: Anti-Bacterial Agents; Bone Regeneration; Fusobacterium nucleatum; Materials Testing; Metronidazole; | 2021 |
Direct current exerts electricidal and bioelectric effects on Porphyromonas gingivalis biofilms partially via promoting oxidative stress and antibiotic transport.
Topics: Amoxicillin; Anti-Bacterial Agents; Biofilms; Electricity; Humans; Metronidazole; Microbial Sensitiv | 2022 |
Topics: Anti-Bacterial Agents; Celecoxib; Doxycycline; Humans; Hydroxyapatites; Matrix Metalloproteinase 13; | 2022 |
Silver Nanoparticles as Chlorhexidine and Metronidazole Drug Delivery Platforms: Their Potential Use in Treating Periodontitis.
Topics: Animals; Chlorhexidine; Humans; Metal Nanoparticles; Metronidazole; Mice; Periodontitis; Pharmaceuti | 2022 |
Concise evaluation and therapeutic guidelines for severe periodontitis: A public health perspective.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Cipr | 2022 |
Smoking negatively impacts the clinical, microbiological, and immunological treatment response of young adults with Grade C periodontitis.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Follow-Up Studies; Gingival Crevicular Fluid; Hu | 2022 |
Comprehensive reparative effects of bacteriostatic poly(L-lactide-co-glycolide)/poly(L-lactide-co-ε-caprolactone) electrospinning membrane on alveolar bone defects in progressive periodontitis.
Topics: Animals; Anti-Bacterial Agents; Humans; Metronidazole; Minocycline; Periodontitis; Rats | 2023 |
Coaxial electrospun nanofibers as drug delivery system for local treatment of periodontitis.
Topics: Anti-Bacterial Agents; Drug Delivery Systems; Drug Liberation; Humans; Metronidazole; Nanofibers; Pe | 2023 |
[Use of antimicrobial agents in periodontology].
Topics: Amoxicillin; Anti-Bacterial Agents; Antibiotic Prophylaxis; Chlorhexidine; Humans; Metronidazole; Pe | 2019 |
Periodontal therapy increases neutrophil extracellular trap degradation.
Topics: Adult; Amoxicillin; Animals; Anti-Bacterial Agents; Cells, Cultured; Chronic Disease; Extracellular | 2020 |
Significant Short-Term Shifts in the Microbiomes of Smokers With Periodontitis After Periodontal Therapy With Amoxicillin & Metronidazole as Revealed by 16S rDNA Amplicon Next Generation Sequencing.
Topics: Amoxicillin; Anti-Bacterial Agents; DNA, Ribosomal; Follow-Up Studies; High-Throughput Nucleotide Se | 2020 |
One-Stage Full Mouth Instrumentation (OSFMI): Clinical Outcomes of an Innovative Protocol for the Treatment of Severe Periodontitis.
Topics: Dental Plaque Index; Dental Scaling; Humans; Metronidazole; Periodontal Pocket; Periodontitis; Treat | 2020 |
Specific Anti-biofilm Activity of Carbon Quantum Dots by Destroying
Topics: Animals; Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Carbon; Escherichia coli; Gene Express | 2020 |
Microbiome changes in young periodontitis patients treated with adjunctive metronidazole and amoxicillin.
Topics: Amoxicillin; Bacteria; Dental Plaque; Humans; Metronidazole; Microbiota; Periodontitis; RNA, Ribosom | 2021 |
Microbiome changes in young periodontitis patients treated with adjunctive metronidazole and amoxicillin.
Topics: Amoxicillin; Bacteria; Dental Plaque; Humans; Metronidazole; Microbiota; Periodontitis; RNA, Ribosom | 2021 |
Microbiome changes in young periodontitis patients treated with adjunctive metronidazole and amoxicillin.
Topics: Amoxicillin; Bacteria; Dental Plaque; Humans; Metronidazole; Microbiota; Periodontitis; RNA, Ribosom | 2021 |
Microbiome changes in young periodontitis patients treated with adjunctive metronidazole and amoxicillin.
Topics: Amoxicillin; Bacteria; Dental Plaque; Humans; Metronidazole; Microbiota; Periodontitis; RNA, Ribosom | 2021 |
Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide.
Topics: Animals; Anti-Infective Agents; Chitosan; Disease Models, Animal; Disease Progression; Lactic Acid; | 2018 |
Clinical and microbiological effects of scaling and root planing, metronidazole and amoxicillin in the treatment of diabetic and non-diabetic subjects with periodontitis: A cohort study.
Topics: Amoxicillin; Anti-Bacterial Agents; Cohort Studies; Combined Modality Therapy; Dental Plaque; Dental | 2018 |
Development and evaluation of mucoadhesive buccal tablet containing metronidazole for the treatment of periodontitis and gingivitis.
Topics: Adhesiveness; Anti-Infective Agents; Drug Development; Gingivitis; Humans; Hypromellose Derivatives; | 2018 |
Periodontal treatment prevents arthritis in mice and methotrexate ameliorates periodontal bone loss.
Topics: Alveolar Bone Loss; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Chlorhe | 2019 |
Assessment of viable periodontal pathogens by reverse transcription quantitative polymerase chain reaction.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Azides; Bacteria; Bacteri | 2013 |
Evaluation of cross-linked chitosan microparticles containing metronidazole for periodontitis treatment.
Topics: Chemistry, Pharmaceutical; Chitosan; Cross-Linking Reagents; Emulsions; Glutaral; Hydrogels; Metroni | 2013 |
Polymersome-mediated intracellular delivery of antibiotics to treat Porphyromonas gingivalis-infected oral epithelial cells.
Topics: Anti-Bacterial Agents; Bacteroidaceae Infections; Cells, Cultured; Doxycycline; Gingiva; Gingival Di | 2013 |
Design of a multiple drug delivery system directed at periodontitis.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Cellulose; Delayed-Action Preparations; Doxycycline | 2013 |
Recurrent lung infection due to chronic peri-odontitis.
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; Diagnos | 2013 |
Catecholamines promote the expression of virulence and oxidative stress genes in Porphyromonas gingivalis.
Topics: Adrenergic Agonists; Anti-Infective Agents; Bacterial Proteins; Bacteriological Techniques; DNA-Bind | 2014 |
Effect of periodontal treatment on peak serum levels of inflammatory markers.
Topics: Acute-Phase Proteins; Amoxicillin; Anti-Infective Agents; Biomarkers; Combined Modality Therapy; Cyt | 2014 |
Biodegradable nanofibrous drug delivery systems: effects of metronidazole and ciprofloxacin on periodontopathogens and commensal oral bacteria.
Topics: Aggregatibacter actinomycetemcomitans; Anti-Infective Agents; Biofilms; Chromatography, High Pressur | 2014 |
Combinatorial effects of amoxicillin and metronidazole on selected periodontal bacteria and whole plaque samples.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Dental Plaque; Drug Resis | 2014 |
Diagnosis and prescribing pattern of antibiotics and painkillers among dentists.
Topics: Adolescent; Adult; Amoxicillin; Analgesics; Anti-Bacterial Agents; Child; Child, Preschool; Cross-Se | 2015 |
Periodontology: antibiotics protocol.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Humans; Metronida | 2014 |
Evaluation of metronidazole-loaded poly(3-hydroxybutyrate) membranes to potential application in periodontitis treatment.
Topics: Anti-Bacterial Agents; Drug Evaluation, Preclinical; Guided Tissue Regeneration, Periodontal; Humans | 2016 |
In-situ forming composite implants for periodontitis treatment: How the formulation determines system performance.
Topics: Adhesives; Adult; Aged; Anti-Bacterial Agents; Bacteria; Chemistry, Pharmaceutical; Doxycycline; Dru | 2015 |
Periodontitis associated with plasminogen deficiency: a case report.
Topics: Adolescent; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Combined Modality Therapy; Conju | 2015 |
Observation of trichomonads infection in a child with periodontitis by direct microscopy at the dental office.
Topics: Animals; Antiprotozoal Agents; Child; Dental Offices; Humans; Hydrogen Peroxide; Male; Metronidazole | 2015 |
Lemierre's Syndrome Associated with Periodontal Injury-derived Odontogenic Infection that Did Not Respond to Meropenem.
Topics: Adult; Anti-Bacterial Agents; Clindamycin; Dyspnea; Fever; Fusobacterium Infections; Fusobacterium n | 2015 |
Development and Evaluation of Biodegradable Chitosan Films of Metronidazole and Levofloxacin for the Management of Periodontitis.
Topics: Adult; Anti-Bacterial Agents; Chitosan; Drug Carriers; Drug Delivery Systems; Drug Liberation; Esche | 2016 |
Local antibiotic delivery in periodontitis: drug release and its effect on supragingival biofilms.
Topics: Anti-Bacterial Agents; Biofilms; Drug Delivery Systems; Drug Liberation; Humans; Metronidazole; Mode | 2016 |
Formulation and evaluation of PLA and PLGA in situ implants containing secnidazole and/or doxycycline for treatment of periodontitis.
Topics: Absorbable Implants; Chemistry, Pharmaceutical; Doxycycline; Drug Carriers; Drug Combinations; Drug | 2008 |
Formulation and evaluation of secnidazole or doxycycline dento-oral gels.
Topics: Administration, Oral; Anti-Bacterial Agents; Chemistry, Pharmaceutical; Doxycycline; Gels; Humans; M | 2008 |
[Vaginal infections associated with bacterial vaginosis and periodontal disease--effective diagnostic and therapeutic possibilities].
Topics: Anti-Bacterial Agents; Clindamycin; Congresses as Topic; Drug Therapy, Combination; Female; HIV Infe | 2008 |
Papillon-Lefèvre syndrome: a case report.
Topics: Adolescent; Amoxicillin; Anti-Bacterial Agents; Consanguinity; Drug Combinations; Humans; Male; Metr | 2009 |
Microbial changes in periodontitis successfully treated by mechanical plaque removal and systemic amoxicillin and metronidazole.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteria; Biodiversity; Dental Scaling; DNA, Bacterial; D | 2009 |
[Antimicrobial activity determination of the preparations used in comprehensive treatment of patients with parodontitis].
Topics: Actihaemyl; Anti-Infective Agents; Cellulose; Choline; Fluorescence; Glycerol; Humans; Lasers; Metro | 2009 |
Comparisons of subgingival microbial profiles of refractory periodontitis, severe periodontitis, and periodontal health using the human oral microbe identification microarray.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteria; Bacteroides; Bacteroidetes; Campylobacter; Chro | 2009 |
Antibiotics in periodontics: right or wrong?
Topics: Amoxicillin; Anti-Bacterial Agents; Bacteroidaceae Infections; Combined Modality Therapy; Dental Pla | 2009 |
Effect of metronidazole and modulation of cytokine production on human periodontal ligament cells.
Topics: Adult; Anti-Infective Agents; Bacteroidaceae Infections; Cell Proliferation; Cell Survival; Cells, C | 2010 |
The severity, extent and recurrence of necrotizing periodontal disease in relation to HIV status and CD4+ T cell count.
Topics: Adolescent; Adult; Anti-Infective Agents; Anti-Infective Agents, Local; CD4 Lymphocyte Count; Child; | 2010 |
Additive or synergistic antimicrobial effects of amoxicillin and metronidazole on whole plaque samples: a preliminary report.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteria, Anaerobic; Biofilms; Colony Count, Microbial; D | 2011 |
Antibiotic susceptibility of cocultures in polymicrobial infections such as peri-implantitis or periodontitis: an in vitro model.
Topics: Acetamides; Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Amoxicillin; Amoxicill | 2011 |
Release of metronidazole from electrospun poly(L-lactide-co-D/L-lactide) fibers for local periodontitis treatment.
Topics: Absorbable Implants; Aggregatibacter actinomycetemcomitans; Anti-Infective Agents; Biocompatible Mat | 2012 |
Formulation development of physiological environment responsive periodontal drug delivery system for local delviery of metronidazole benzoate.
Topics: Anti-Infective Agents; Chemistry, Pharmaceutical; Diffusion; Drug Delivery Systems; Drug Design; Gel | 2013 |
Occurrence and antimicrobial susceptibility of Porphyromonas spp. and Fusobacterium spp. in dogs with and without periodontitis.
Topics: Animals; Anti-Bacterial Agents; Bacteroidaceae Infections; Clarithromycin; Dental Plaque; Dog Diseas | 2012 |
Local concentration of systemic amoxicillin and metronidazole in healthy and inflamed gingiva: a comparative in vivo study.
Topics: Administration, Oral; Amoxicillin; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Drug | 2012 |
Antibiotic susceptibility of periodontal Enterococcus faecalis.
Topics: Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Anti-Bacterial Agents; Anti- | 2013 |
[Relationship between salivary lipid peroxidation and the strategy of local dichloran gel treatment for periodontitis].
Topics: Adult; Aged; Aniline Compounds; Anti-Infective Agents; Chronic Disease; Drug Therapy, Combination; F | 2002 |
Local antibiotic therapy guided by microbiological diagnosis.
Topics: Administration, Topical; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; | 2002 |
[Clinical effects of metronidazole-ofloxacin gel as an adjunct to conventional therapy for periodontitis].
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Delayed-Action Preparations; Female; Ge | 2001 |
[Study of bacteriology on local application of Tinidazole stilus in treatment for periodontitis].
Topics: Administration, Topical; Adult; Aged; Anti-Bacterial Agents; Female; Humans; Male; Metronidazole; Mi | 2001 |
Change of antibiotic susceptibility following periodontal therapy. A pilot study in aggressive periodontal disease.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin-Potassium Clavulanate Combination; Anti-Ba | 2003 |
Re: Rationale for use of antibiotics in periodontics. Walker C, Karpinia K (2002;73:1188-1196).
Topics: Anti-Infective Agents; Humans; Metronidazole; Periodontitis | 2003 |
Modulation of Porphyromonas gingivalis proteinase activity by suboptimal doses of antimicrobial agents.
Topics: Adhesins, Bacterial; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Bac | 2003 |
Effectiveness of antimicrobial adjuncts to scaling and root-planing therapy for periodontitis.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Chlorhexidine; Chronic Disease; Combined Modality Therapy | 2004 |
Necrotising ulcerative gingivitis/periodontitis as indicators of HIV-infection.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Anti-Infective Agents; Anti-Infective Ag | 2004 |
Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis.
Topics: Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacteria, Anaerob | 2004 |
Efficacy of antibiotics against periodontopathogenic bacteria within epithelial cells: an in vitro study.
Topics: Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Anti-Infective Agents; Aza Compounds; | 2004 |
Periodontal antimicrobials--finding the right solutions.
Topics: Adolescent; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Chlorhexidine; Ciprofl | 2005 |
Development of a system to adsorb drugs onto calcium phosphate materials.
Topics: Adsorption; Ampicillin; Anti-Infective Agents; Calcium Phosphates; Coated Materials, Biocompatible; | 2005 |
[Comparative study by pH-tests of the efficacy of antimicrobial agents in oral cavity].
Topics: Adult; Anti-Infective Agents, Local; Bacteria; Chlorhexidine; Dental Caries; Female; Humans; Hydroge | 2005 |
[Comparative study of 2 antibiotic combinations in the treatment of rapidly progressing periodontitis].
Topics: Adolescent; Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Clavulanic Acid; Drug | 2005 |
Papillon-Lefèvre syndrome: a successful outcome.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Child; Combined Modality Therapy; Dental | 2005 |
RvE1 protects from local inflammation and osteoclast- mediated bone destruction in periodontitis.
Topics: Administration, Topical; Alveolar Bone Loss; Animals; Eicosapentaenoic Acid; Humans; Inflammation; L | 2006 |
Studies on periodontitis and analyses of individuals at risk for periodontal diseases.
Topics: Adult; Anti-Infective Agents; Chronic Disease; Diabetes Mellitus, Type 2; Female; Genetic Predisposi | 2006 |
Influence of different treatment approaches on non-submerged and submerged healing of ligature induced peri-implantitis lesions: an experimental study in dogs.
Topics: Aluminum Silicates; Animals; Anti-Infective Agents; Dental Implants; Disease Models, Animal; Dogs; E | 2006 |
Heresy? Treatment of chronic periodontitis with systemic antibiotics only.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Chronic Disease; Dental Scaling; Drug Com | 2006 |
The efficacy of non-surgical and systemic antibiotic treatment on smoking and non-smoking periodontitis patients.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Dental Plaque Index; Humans; | 2006 |
Timing affects the clinical outcome of adjunctive systemic antibiotic therapy for generalized aggressive periodontitis.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Combined Modality Therapy; Dental Scaling; Drug Administr | 2007 |
Clinical and microbiological effects of a combined mechanic-antibiotic therapy in subjects with Actinobacillus actinomycetemcomitans-associated periodontitis.
Topics: Actinobacillus Infections; Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Ch | 2007 |
Incomplete adherence to an adjunctive systemic antibiotic regimen decreases clinical outcomes in generalized aggressive periodontitis patients: a pilot retrospective study.
Topics: Adolescent; Adult; Amoxicillin; Anti-Infective Agents; Epidemiologic Methods; Female; Humans; Male; | 2007 |
Susceptibility of oral obligate anaerobes to telithromycin, moxifloxacin and a number of commonly used antibacterials.
Topics: Adult; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infec | 2007 |
Antibiotic resistance in an in vitro subgingival biofilm model.
Topics: Adult; Aged; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti | 2007 |
Chitosan inserts for periodontitis: influence of drug loading, plasticizer and crosslinking on in vitro metronidazole release.
Topics: Animals; Anti-Infective Agents; Chemistry, Pharmaceutical; Chitosan; Cross-Linking Reagents; Drug Ca | 2007 |
Metronidazole in periodontitis. I. Clinical and bacteriological results after 15 to 30 weeks.
Topics: Alveolar Process; Bacteria, Anaerobic; Bacteroides; Bone Resorption; Dental Prophylaxis; Dental Scal | 1984 |
Simple bacteriological methods to assess changes in subgingival microflora produced by metronidazole-containing acrylic strips placed into periodontal pockets.
Topics: Acrylic Resins; Bacteria; Bacteriological Techniques; Delayed-Action Preparations; Gingiva; Humans; | 1984 |
Bone resorbing activity of gingiva from beagle dogs following metronidazole and indomethacin therapy.
Topics: Alveolar Process; Animals; Bone Resorption; Dogs; Gingivitis; Indomethacin; Metronidazole; Periodont | 1981 |
The predominant cultivable subgingival flora of beagle dogs following ligature placement and metronidazole therapy.
Topics: Animals; Bacteria; Dogs; Gingiva; Metronidazole; Periodontitis | 1981 |
Subgingival metronidazole in acrylic resin vs. chlorhexidine irrigation in the control of chronic periodontitis.
Topics: Acrylic Resins; Adult; Chlorhexidine; Delayed-Action Preparations; Female; Humans; Male; Metronidazo | 1983 |
Subgingival metronidazole in dialysis tubing and subgingival chlorhexidine irrigation in the control of chronic inflammatory periodontal disease.
Topics: Administration, Topical; Chlorhexidine; Dental Plaque Index; Humans; Intubation; Metronidazole; Peri | 1984 |
Treatment of an isolated deep defect.
Topics: Combined Modality Therapy; Humans; Male; Metronidazole; Periodontal Pocket; Periodontitis | 1983 |
Comparison of the immediate effects on the sub-gingival microflora of acrylic strips containing 40% chlorhexidine, metronidazole or tetracycline.
Topics: Acrylic Resins; Administration, Topical; Bacteria; Chlorhexidine; Dental Plaque; Humans; Metronidazo | 1984 |
Slow release metronidazole and a simplified mechanical oral hygiene regimen in the control of chronic periodontitis.
Topics: Chronic Disease; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Evaluation; Hum | 1984 |
In vitro activity of rodogyl against putative periodontopathic bacteria.
Topics: Bacteria; Drug Combinations; Humans; Leucomycins; Metronidazole; Microbial Sensitivity Tests; Period | 1983 |
Treatment of periodontal infections due to anaerobic bacteria with short-term treatment with metronidazole.
Topics: Adolescent; Adult; Bacteroides; Dental Plaque; Epithelial Attachment; Female; Humans; Male; Metronid | 1981 |
Mitsuokella dentalis in human periodontitis.
Topics: Adolescent; Adult; Age Distribution; Aged; Amoxicillin; Anti-Bacterial Agents; Bacteroides; Ciproflo | 1994 |
Metronidazole susceptibility factors in Actinobacillus actinomycetemcomitans.
Topics: 4-Aminobenzoic Acid; Aggregatibacter actinomycetemcomitans; Bacteriological Techniques; Humans; Keto | 1995 |
Elimination of Elyzol 25% Dentalgel matrix from periodontal pockets.
Topics: Absorption; Adult; Chromatography, High Pressure Liquid; Dental Scaling; Female; Gels; Gingival Crev | 1995 |
Kinetics of spiramycin/metronidazole (Rodogyl) in human gingival crevicular fluid, saliva and blood.
Topics: Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Bacteria; Drug Combinations; Female; Gingival Crev | 1994 |
Frequency of Entamoeba gingivalis among periodontal and patients under chemotherapy.
Topics: Adult; Animals; Entamoeba; Entamoebiasis; Gingiva; Humans; Metronidazole; Neoplasms; Periodontitis | 1994 |
Antimicrobial susceptibility of periodontopathic bacteria associated with failing implants.
Topics: Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacteria, Anaerob | 1995 |
Topical antibiotics and gastric flora.
Topics: Drug Resistance, Microbial; Helicobacter pylori; Humans; Metronidazole; Periodontitis | 1994 |
Campylobacter rectus in human periodontitis.
Topics: Adolescent; Adult; Age Distribution; Aged; Campylobacter; Chi-Square Distribution; Ciprofloxacin; Cr | 1993 |
Beta-hemolytic streptococci in advanced periodontitis.
Topics: Adolescent; Adult; Age Factors; Aged; Ciprofloxacin; Colony Count, Microbial; Cross-Sectional Studie | 1993 |
Long-standing bacteremia caused by oral Actinobacillus actinomycetemcomitans in a patient with a pacemaker.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Amoxicillin; Bacteremia; Drug Ther | 1993 |
Microbial composition and pattern of antibiotic resistance in subgingival microbial samples from patients with refractory periodontitis.
Topics: Adult; Aged; Bacteria, Anaerobic; Candida; Drug Resistance, Microbial; Female; Humans; Male; Metroni | 1993 |
Salivary levels of suspected periodontal pathogens in relation to periodontal status and treatment.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Antitrichomonal Agents; Bacteria, Anaerobic; Cam | 1995 |
Pulsed oral irrigation in the management of inflammatory periodontal diseases.
Topics: Chlorhexidine; Dental Devices, Home Care; Gingivitis; Humans; Metronidazole; Mouthwashes; Oral Hygie | 1993 |
Distribution of biotypes and antimicrobial susceptibility of Actinobacillus actinomycetemcomitans.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Antitrichomonal Age | 1995 |
[Antibacterial therapy in the combined treatment of periodontitis].
Topics: 4-Quinolones; Adolescent; Adult; Anti-Bacterial Agents; Bacteria; Chronic Disease; Dose-Response Rel | 1996 |
Distribution and genetic analysis of oral Prevotella intermedia and Prevotella nigrescens.
Topics: Adult; Age Factors; Aged; Bacterial Typing Techniques; Case-Control Studies; Child, Preschool; Disea | 1996 |
Microbiological and immunohistological findings in a patient with Papillon-Lefèvre syndrome.
Topics: Aggregatibacter actinomycetemcomitans; Amoxicillin; Child; Dental Care for Chronically Ill; Dental C | 1996 |
Putative periodontal pathogens, antibody titres and avidities to them in a longitudinal study of patients with resistant periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Antibodies, Bacterial; Antibody Affinity; | 1996 |
The effect of antimicrobial therapy on periimplantitis lesions. An experimental study in the dog.
Topics: Amoxicillin; Animals; Anti-Infective Agents; Dental Implants; Dental Plaque; Dogs; Equipment Contami | 1996 |
Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Anaerobiosis; Anti-Bacterial Agents; Bacteroidaceae In | 1997 |
Re: Non-surgical treatment of patients with periodontitis.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Double-Bl | 1997 |
Periodontitis patient and the spouse: periodontal bacteria before and after treatment.
Topics: Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Bacteria; Campylobacter; Dental Calcul | 1997 |
Eradication of Actinobacillus actinomycetemcomitans from the oral cavity in adult periodontitis.
Topics: Actinobacillus Infections; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial | 1998 |
The growth of nonsurgical treatment of periodontitis. Interview by Randall L. Valentine.
Topics: Anti-Infective Agents; Dental Abutments; Dental Scaling; Diagnosis, Differential; Humans; Metronidaz | 1997 |
Metronidazole does not enhance effective non-surgical treatment of periodontitis.
Topics: Antitrichomonal Agents; Humans; Metronidazole; Periodontitis | 1998 |
[The effect of a combined transplant on reparative osteogenesis in experimental defects of the jaw (the late results)].
Topics: Animals; Anti-Infective Agents; Bone Transplantation; Combined Modality Therapy; Drug Carriers; Fura | 1998 |
Treatment considerations in rapidly progressive periodontitis: a case report.
Topics: Adult; Age of Onset; Amoxicillin; Anti-Bacterial Agents; Antitrichomonal Agents; Colony Count, Micro | 1998 |
Attempts to obtain re-osseointegration following experimental peri-implantitis in dogs.
Topics: Alveolar Process; Animals; Anti-Infective Agents; Bone Regeneration; Chlorhexidine; Dental Implants; | 1999 |
Metronidazole susceptibility testing of anaerobic bacteria associated with periodontal disease.
Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; Drug Resistance, Microbial; Fusobacterium; Humans; Metro | 1999 |
Evaluation of the Etest for determining the in-vitro susceptibilities of Prevotella intermedia isolates to metronidazole.
Topics: Anti-Bacterial Agents; Evaluation Studies as Topic; Humans; Metronidazole; Microbial Sensitivity Tes | 1999 |
Antibiotic susceptibility of putative periodontal pathogens in advanced periodontitis patients.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bacteria, Anaerobic; Bi | 1999 |
Microbiotica associated with refractory periodontis. Prevalence and antibiotic susceptibility.
Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; Erythromycin; Gingiva; Humans; Metronidazole; Mouth Muco | 1999 |
Resistance profile survey of 50 periodontal strains of Actinobacillus actinomyectomcomitans.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Amoxicillin-Potassium Clavulanate Combina | 1999 |
The effect of adjunctive antibiotic cover during scaling and rootplaning: a case report.
Topics: Adult; Amoxicillin-Potassium Clavulanate Combination; Dental Scaling; Drug Therapy, Combination; Hum | 1997 |
Complicated management of a patient with rapidly progressive periodontitis: a case report.
Topics: Adult; Alveolar Bone Loss; Anti-Bacterial Agents; Ciprofloxacin; Dental Scaling; Drug Therapy, Combi | 1997 |
Resolution of peri-implantitis following treatment. An experimental study in the dog.
Topics: Administration, Oral; Administration, Topical; Alveolar Bone Loss; Amoxicillin; Animals; Anti-Bacter | 1999 |
On the dosage of antibiotics in clinical trials.
Topics: Anti-Infective Agents; Combined Modality Therapy; Humans; Metronidazole; Periodontal Diseases; Perio | 1999 |
The role of controlled drug delivery for periodontitis. The Research, Science and Therapy Committee of the American Academy of Periodontology.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Delayed-A | 2000 |
Influence of antimicrobial subinhibitory concentrations on hemolytic activity and bacteriocin-like substances in oral Fusobacterium nucleatum.
Topics: Adult; Anti-Bacterial Agents; Bacteriocins; Chlorhexidine; Dose-Response Relationship, Drug; Fusobac | 2000 |
The effect of systemic antibiotics in the treatment of patients with recurrent periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents | 2001 |
Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole.
Topics: Actinomyces; Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Bacteria; Bacteroides; | 2001 |
The clinical relevance of microbiologic testing: a comparative analysis of microbiologic samples secured from the same sites and cultured in two independent laboratories.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteria; Bacteriological Techniques; Bacteroides; Campyl | 2001 |
Generalized cervical root resorption associated with periodontal disease.
Topics: Acids; Adult; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial | 2001 |
Re-osseointegration after treatment of peri-implantitis at different implant surfaces. An experimental study in the dog.
Topics: Alveolar Bone Loss; Amoxicillin; Animals; Anti-Bacterial Agents; Bone Regeneration; Dental Implantat | 2001 |
[A comparative study of various evaluation methods of the antibiotic sensitivity of strict anaerobic bacteria of the subgingival flora].
Topics: Adult; Amoxicillin; Ampicillin; Anti-Bacterial Agents; Bacteria, Anaerobic; Campylobacter; Chronic D | 2001 |
[Prescription of antibiotics for periodontitis patients by dental practitioners in the Netherlands].
Topics: Amoxicillin; Anti-Infective Agents; Attitude of Health Personnel; Dental Health Surveys; Drug Prescr | 1995 |
[Validation of the optimal concentration of Metrogil-denta preparation in the treatment of periodontal inflammations].
Topics: Adult; Aged; Anti-Infective Agents; Drug Combinations; Female; Humans; Male; Metronidazole; Middle A | 2002 |
Treatment of Papillon-Lefèvre syndrome periodontitis.
Topics: Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti- | 2002 |
Statistical modeling of tooth mobility after treating adult periodontitis.
Topics: Adult; Anti-Bacterial Agents; Chronic Disease; Colony Count, Microbial; Dental Plaque Index; Electro | 2002 |
[Clinical and bacteriological studies with metronidazol in endodontic therapy (author's transl)].
Topics: Aerobiosis; Anaerobiosis; Dental Pulp Cavity; Dental Pulp Necrosis; Humans; Metronidazole; Periodont | 1978 |
Healthy and diseased gingiva.
Topics: Adult; Child; Chronic Disease; Dental Plaque; Diabetes Complications; Gingiva; Gingival Diseases; Gi | 1975 |
HIV-related gingival and periodontal disorders.
Topics: AIDS-Related Opportunistic Infections; Gingivitis; HIV Infections; Humans; Metronidazole; Periodonti | 1992 |
Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis.
Topics: Adult; Age Factors; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Bacteroi | 1992 |
E-test: a new technique for antimicrobial susceptibility testing for periodontal microorganisms.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Ampicillin; Anti-Bacterial Agents; Bacteria; Bac | 1992 |
Gingival crevicular fluid gelatinase and its relationship to periodontal disease in human subjects.
Topics: Adult; Aged; Analysis of Variance; Biomarkers; Chi-Square Distribution; Clinical Enzyme Tests; Colla | 1992 |
Systemic absorption of metronidazole after application of a metronidazole 25% dental gel.
Topics: Absorption; Adult; Biological Availability; Delayed-Action Preparations; Drug Implants; Female; Gels | 1992 |
The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog.
Topics: Animals; Bacteria, Aerobic; Bacteria, Anaerobic; Colony Count, Microbial; Delayed-Action Preparation | 1992 |
In vitro susceptibilities of Actinobacillus actinomycetemcomitans to a number of antimicrobial combinations.
Topics: Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Drug Intera | 1992 |
Peptostreptococcus micros in human periodontitis.
Topics: Adult; Aged; Aged, 80 and over; Aggressive Periodontitis; Anti-Bacterial Agents; Chi-Square Distribu | 1992 |
Gingival crevicular fluid of patients with gingivitis or periodontal disease: evaluation of elastase-alpha 1 proteinase inhibitor complex.
Topics: Adult; Aged; alpha 1-Antitrypsin; Anti-Infective Agents; Dental Scaling; Drug Combinations; Female; | 1992 |
The effects of antimicrobial acrylic strips on the subgingival microflora in chronic periodontitis.
Topics: Acrylic Resins; Adult; Bacteria; Bacteria, Aerobic; Bacteria, Anaerobic; Chlorhexidine; Chronic Dise | 1992 |
Effect of metronidazole on experimental periodontitis: cell population characteristics.
Topics: Animals; Biopsy; Cell Count; Drug Evaluation, Preclinical; Gingiva; Metronidazole; Neutrophils; Peri | 1992 |
[Chronic conjunctivitis caused by oral anaerobic germs].
Topics: Adult; Amoxicillin; Bacteroides; Chronic Disease; Conjunctivitis; Drug Therapy, Combination; Humans; | 1991 |
Antimicrobials in periodontitis: a clinical approach.
Topics: Amoxicillin; Drug Combinations; Humans; Metronidazole; Periodontitis; Spiramycin; Tetracycline | 1991 |
Identification, and susceptibility to seven antimicrobial agents, of 61 gram-negative anaerobic rods from periodontal pockets.
Topics: Amoxicillin; Anaerobiosis; Anti-Bacterial Agents; Bacteriological Techniques; Bacteroides; Clavulani | 1991 |
In vitro antimicrobial sensitivity of enteric rods and pseudomonads from advanced adult periodontitis.
Topics: Adult; Ciprofloxacin; Enterobacteriaceae; Gram-Negative Anaerobic Bacteria; Humans; Metronidazole; M | 1990 |
[Effects of subgingival antimicrobial irrigation in chronic periodontitis--clinical observation].
Topics: Adult; Chi-Square Distribution; Chlorhexidine; Chronic Disease; Female; Humans; Male; Metronidazole; | 1990 |
Evaluation of the activity of four antimicrobial agents using an in vitro rapid micromethod against oral streptococci and various bacterial strains implicated in periodontitis.
Topics: Actinobacillus; Actinomyces; Amoxicillin; Bacteria; Bacteroides; Capnocytophaga; Doxycycline; Drug E | 1990 |
Microbiology in diagnosis and treatment of severe periodontitis. A report of four cases.
Topics: Actinobacillus; Adult; Amoxicillin; Colony Count, Microbial; Combined Modality Therapy; Dental Scali | 1990 |
Use of strips containing tetracycline hydrochloride or metronidazole for the treatment of advanced periodontal disease.
Topics: Administration, Topical; Calorimetry, Differential Scanning; Dental Plaque; Gingiva; Humans; Metroni | 1989 |
[The use of antibiotics].
Topics: Adult; Anti-Bacterial Agents; Bacteria; Child; Clindamycin; Humans; Metronidazole; Microbial Sensiti | 1989 |
Clinical and microbiologic changes following the irrigation of periodontal pockets with metronidazole or stannous fluoride.
Topics: Fluorides; Humans; Metronidazole; Periodontal Pocket; Periodontitis; Therapeutic Irrigation; Tin Flu | 1989 |
Systemic metronidazole in the treatment of periodontitis.
Topics: Administration, Oral; Adult; Bacteria; Bacteroides; Dental Plaque; Dental Prophylaxis; Dental Scalin | 1989 |
[Experimental study of a metronidazole gel inserted in periodontal pockets].
Topics: Adult; Analysis of Variance; Dental Scaling; Female; Gels; Humans; Male; Metronidazole; Middle Aged; | 1989 |
Metronidazole plus amoxycillin in the treatment of Actinobacillus actinomycetemcomitans associated periodontitis.
Topics: Actinobacillus; Adolescent; Adult; Aggressive Periodontitis; Amoxicillin; Bacteroides; Drug Combinat | 1989 |
Metronidazole therapy for periodontitis.
Topics: Dental Plaque; Dental Scaling; Double-Blind Method; Humans; Metronidazole; Patient Compliance; Perio | 1987 |
Combined antibiotic (metronidazole) and mechanical treatment effects on the subgingival bacterial flora of sites with recurrent periodontal disease.
Topics: Adult; Bacteria; Dental Prophylaxis; Dental Scaling; Humans; Metronidazole; Middle Aged; Periodontal | 1988 |
Effect of periodontal therapy on alveolar bone as measured by subtraction radiography.
Topics: Alveolar Process; Alveoloplasty; Bone Resorption; Dental Scaling; Equipment Design; Humans; Metronid | 1988 |
[Metronidazole-containing teflon fibers in the treatment of periodontitis].
Topics: Administration, Topical; Adolescent; Adult; Bacteria, Anaerobic; Delayed-Action Preparations; Female | 1988 |
Factors associated with occurrence and reversibility of connective tissue attachment loss.
Topics: Animals; Bacterial Physiological Phenomena; Connective Tissue; Dental Plaque; Metronidazole; Periodo | 1988 |
Activity of metronidazole and its hydroxy metabolite against clinical isolates of Actinobacillus actinomycetemcomitans.
Topics: Actinobacillus; Humans; Metronidazole; Microbial Sensitivity Tests; Periodontitis | 1988 |
[Bioadhesive polymeric films for the application onto the oral mucosa].
Topics: Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Metronidazole; Periodontal Dressings; Periodon | 1988 |
Microbial and clinical measurements of periodontal pockets during sequential periods of non-treatment, mechanical debridement and metronidazole therapy.
Topics: Adult; Bacteria; Bacteroides; Combined Modality Therapy; Eikenella corrodens; Fusobacterium; Humans; | 1987 |
Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis.
Topics: Bacteria, Anaerobic; Dental Plaque; Humans; Metronidazole; Niridazole; Periodontal Pocket; Periodont | 1987 |
Effect of metronidazole on development of subgingival plaque and experimental periodontitis.
Topics: Animals; Bacteria; Connective Tissue; Dental Cementum; Dental Enamel; Dental Plaque; Gingiva; Metron | 1986 |
Clinical and microbiologic effects of single-dose metronidazole or scaling and root planing in treatment of adult periodontitis.
Topics: Adult; Bacteria; Dental Plaque Index; Dental Prophylaxis; Dental Scaling; Drug Administration Schedu | 1986 |
The development and clinical use of acrylic strips containing anti-microbial agents in the management of chronic periodontitis.
Topics: Acrylic Resins; Anti-Bacterial Agents; Bacteria; Bacterial Physiological Phenomena; Bacteroides; Chl | 1985 |
The therapeutic use of antimicrobial agents in patients with periodontal disease.
Topics: Bacteria, Anaerobic; Bacterial Infections; Bacteroides Infections; Combined Modality Therapy; Debrid | 1985 |